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https://www.readbyqxmd.com/read/28766982/serum-met-5-enkephalin-levels-are-reduced-in-multiple-sclerosis-and-restored-by-low-dose-naltrexone
#1
Michael D Ludwig, Ian S Zagon, Patricia J McLaughlin
Low-dose naltrexone is a widely used off-label therapeutic prescribed for a variety of immune-related disorders. The mechanism underlying low-dose naltrexone's efficacy for fatigue, Crohn's disease, fibromyalgia, and multiple sclerosis is, in part, intermittent blockade of opioid receptors followed by upregulation of endogenous opioids. Short, intermittent blockade by naltrexone specifically blocks the opioid growth factor receptor resulting in biofeedback events that increase production of the endogenous opioid growth factor (OGF) (chemically termed [Met(5)]-enkephalin) facilitating interactions between opioid growth factor and opioid growth factor receptor that ultimately, result in inhibited cell proliferation...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28761205/pain-relief-with-wet-cupping-therapy-in-rats-is-mediated-by-heat-shock-protein-70-and-%C3%A3-endorphin
#2
Imam Subadi, Boya Nugraha, Hening Laswati, Harjanto Josomuljono
BACKGROUND: Wet cupping therapy is a complementary therapy in pain management. The mechanism of this therapy, however, needs further elucidation. Cells injured by wet cupping therapy seem to stimulate the expression of heat shock protein 70 (HSP70). Its benefit in pain reduction could be mediated by the expression of ß-endorphin. This study aimed at determining the correlation between HSP70 and ß-endorphin after wet cupping therapy. METHODS: Sixteen male Wistar rats were divided into control (CG; n=8) and treatment (TG; n=8) groups...
July 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28716934/sigma-1-receptors-control-immune-driven-peripheral-opioid-analgesia-during-inflammation-in-mice
#3
Miguel A Tejada, Angeles Montilla-García, Shane J Cronin, Domagoj Cikes, Cristina Sánchez-Fernández, Rafael González-Cano, M Carmen Ruiz-Cantero, Josef M Penninger, José M Vela, José M Baeyens, Enrique J Cobos
Sigma-1 antagonism potentiates the antinociceptive effects of opioid drugs, so sigma-1 receptors constitute a biological brake to opioid drug-induced analgesia. The pathophysiological role of this process is unknown. We aimed to investigate whether sigma-1 antagonism reduces inflammatory pain through the disinhibition of the endogenous opioidergic system in mice. The selective sigma-1 antagonists BD-1063 and S1RA abolished mechanical and thermal hyperalgesia in mice with carrageenan-induced acute (3 h) inflammation...
August 1, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28690569/the-effect-of-different-phases-of-synchrony-on-pain-threshold-in-a-drumming-task
#4
Philip Sullivan, Mishka Blacker
Behavioral synchrony has been linked to endorphin activity (Cohen et al., 2010; Sullivan and Rickers, 2013; Sullivan et al., 2014; Tarr et al., 2015, 2016; Weinstein et al., 2016). This has been called the synchrony effect. Synchrony has two dominant phases of movement; in-phase and anti-phase. The majority of research investigating synchrony's effect on endorphin activity has focused on in-phase synchrony following vigorous activities. The only research to investigate the effects of anti-phase synchrony on endorphin activity found that anti-phase synchronized rowing did not produce the synchrony effect (Sullivan et al...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28687197/opioid-receptor-activation-is-involved-in-neuroprotection-induced-by-trpv1-channel-activation-against-excitotoxicity-in-the-rat-retina
#5
Kenji Sakamoto, Taiyo Kuroki, Tomonori Sagawa, Hiroko Ito, Asami Mori, Tsutomu Nakahara, Kunio Ishii
Recently, we reported that capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, protected against excitotoxicity induced by intravitreal N-methyl-D-aspartic acid (NMDA) in the rats in vivo. It has been reported that morphine, an opioid receptor agonist, ameliorated excitotoxicity induced by ischemia-reperfusion in the retina, and that capsaicin-induced neuroprotection was reduced by naloxone, an opioid receptor antagonist in the brain. The aim of the present study is to clarify whether activation of opioid receptors is involved in the capsaicin-induced neuroprotection in the retina...
July 4, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28684258/effects-of-transcranial-direct-current-stimulation-on-pain-mood-and-serum-endorphin-level-in-the-treatment-of-fibromyalgia-a-double-blinded-randomized-clinical-trial
#6
Eman M Khedr, Eman A H Omran, Nadia M Ismail, Dina H El-Hammady, Samar H Goma, Hassan Kotb, Hannan Galal, Ayman M Osman, Hannan S M Farghaly, Ahmed A Karim, Gehad A Ahmed
BACKGROUND: Recent studies have shown that novel neuro-modulating techniques can have pain-relieving effects in the treatment of chronic pain. The aim of this work is to evaluate the effects of transcranial direct current stimulation (tDCS) in relieving fibromyalgia pain and its relation with beta-endorphin changes. MATERIAL AND METHODS: Forty eligible patients with primary fibromyalgia were randomized to receive real anodal tDCS or sham tDCS of the left motor cortex (M1) daily for 10 days...
June 23, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28675777/effects-of-myricetin-containing-ethanol-solution-on-high-fat-diet-induced-obese-rats
#7
Hsueh-Chin Chao, Pei-Feng Tsai, Sheng-Chi Lee, Yeong-Shenn Lin, Ming-Chang Wu
Myricetin is a natural flavonol widely occurring in wines. Many beneficial effects of myricetin in alcoholic beverages have been reported before, but never including anti-obesity. In the present study, we fed obese male Sprague-Dawley rats with ethanol solutions containing various concentrations of myricetin and found that myricetin may maintain the food intake while reduce the weight-gain, feed efficiency, level of blood lipids, adipocyte size, and weight and size of the perirenal and epididymal adipose tissues (P < 0...
July 4, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28665324/diosmin-a-citrus-nutrient-activates-imidazoline-receptors-to-alleviate-blood-glucose-and-lipids-in-type-1-like-diabetic-rats
#8
Chia-Chen Hsu, Mang Hung Lin, Juei-Tang Cheng, Ming Chang Wu
Diosmin is a nutrient that is widely contained in citrus and that has been indicated to improve glucose metabolism in diabetic disorders. Recently, we demonstrated that diosmin induces β-endorphin to lower hyperglycemia in diabetic rats. However, the mechanisms of diosmin in opioid secretion were unclear. Therefore, we focused on the secretion of opioids from isolated adrenal glands induced by diosmin. The changes in the released β-endorphin-like immunoreactivity (BER) were determined using ELISA. Diosmin increased the BER level in a dose-dependent manner, and this effect was markedly reduced in the absence of calcium ions...
June 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28663110/sucrose-and-naltrexone-prevent-increased-pain-sensitivity-and-impaired-long-term-memory-induced-by-repetitive-neonatal-noxious-stimulation-role-of-bdnf-and-%C3%AE-endorphin
#9
Khawla Q Nuseir, Karem H Alzoubi, Ahmed Alhusban, Areej Bawaane, Mohammed Al-Azzani, Omar F Khabour
Pain in neonates is associated with short and long-term adverse outcomes. Data demonstrated that long-term consequences of untreated pain are linked to the plasticity of the neonate's brain. Sucrose is effective and safe for reducing painful procedures from single events. However, the mechanism of sucrose-induced analgesia is not fully understood. The role of the opioid system in this analgesia using the opioid receptor antagonist Naltrexone was investigated, plus the long-term effects on learning and memory formation during adulthood...
June 27, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28657424/heroin-piracetam-mixture-suggested-mechanisms-of-action-and-risks-of-misinterpretation-for-drug-users
#10
Simone Cappelletti, Francesco Lombardo, Pasquale Vitale, Giuseppe Vallone, Costantino Ciallella
Piracetam is a positive allosteric modulator of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor that has been frequently used in the treatment of cognitive disorders. Press and internet reports indicate that the use of piracetam, as a heroin adulterant, has spread rapidly in some countries, especially in Asia and Europe. Its use, as adulterant, is believed to produce more profound desirable effects, while decreasing hangover. Recent surveys demonstrated that piracetam protects neurons from heroin-induced apoptosis...
January 1, 2017: Medico-legal Journal
https://www.readbyqxmd.com/read/28642689/integrating-neural-circuits-controlling-female-sexual-behavior
#11
REVIEW
Paul E Micevych, Robert L Meisel
The hypothalamus is most often associated with innate behaviors such as is hunger, thirst and sex. While the expression of these behaviors important for survival of the individual or the species is nested within the hypothalamus, the desire (i.e., motivation) for them is centered within the mesolimbic reward circuitry. In this review, we will use female sexual behavior as a model to examine the interaction of these circuits. We will examine the evidence for a hypothalamic circuit that regulates consummatory aspects of reproductive behavior, i...
2017: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/28638432/mechanical-stimulation-of-the-ht7-acupuncture-point-to-reduce-ethanol-self-administration-in-rats
#12
Suk-Yun Kang, O Sang Kwon, Ji-Young Moon, Seong Jin Cho, Kwang-Ho Choi, Junbeom Kim, Seong-Hun Ahn, Yeonhee Ryu
BACKGROUND: Alcoholism, which is a disabling addiction disorder, is a major public health problem worldwide. The present study was designed to determine whether the application of acupuncture at the Shenmen (HT7) point suppresses voluntary alcohol consumption in addicted rats and whether this suppressive effect is potentiated by the administration of naltrexone. METHODS: Rats were initially trained to self-administer a sucrose solution by operating a lever. A mechanical acupuncture instrument (MAI) for objective mechanical stimulation was used on rats whose baseline response had been determined...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28630099/kndy-neurone-activation-prior-to-the-lh-surge-of-the-ewe-is-disrupted-by-lps
#13
Chrysanthi Fergani, Jean Routly, David Jones, Lucy Pickavance, Robert Frank Smith, Hilary Dobson
In the ewe, steroid hormones act on the hypothalamic arcuate nucleus (ARC) to initiate the GnRH/LH surge. Within the ARC, steroid signal transduction may be mediated by dopamine, β-endorphin or neuropeptide Y (NPY) expressing cells, as well as those co-localising kisspeptin, neurokinin B (NKB), and dynorphin (termed KNDy). We investigated the time during the follicular phase when these cells become activated (i.e., co-localise c-Fos) relative to the timing of the LH surge onset and may, therefore, be involved in the surge generating mechanism...
June 19, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28596129/sync-to-link-endorphin-mediated-synchrony-effects-on-cooperation
#14
Martin Lang, Vladimír Bahna, John H Shaver, Paul Reddish, Dimitris Xygalatas
Behavioural synchronization has been shown to facilitate social bonding and cooperation but the mechanisms through which such effects are attained are poorly understood. In the current study, participants interacted with a pre-recorded confederate who exhibited different rates of synchrony, and we investigated three mechanisms for the effects of synchrony on likeability and trusting behaviour: self-other overlap, perceived cooperation, and opioid system activation measured via pain threshold. We show that engaging in highly synchronous behaviour activates all three mechanisms, and that these mechanisms mediate the effects of synchrony on liking and investment in a Trust Game...
June 6, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28587847/molecular-cloning-and-tissue-distribution-of-crh-and-pomc-mrna-in-the-fat-tailed-dunnart-sminthopsis-crassicaudata-an-australian-marsupial
#15
Ellyse B Noy, Melissa K Scott, Sylvia V H Grommen, Kylie A Robert, Bert De Groef
Like all vertebrates, marsupials respond to stressors with the activation of the hypothalamo-pituitary-adrenal axis. However, peptides operating at the higher regulatory levels of this hormonal system, i.e. corticotropin-releasing hormone (CRH) and adrenocorticotropic hormone (ACTH), have not been investigated in marsupials. Here we report the molecular cloning of the precursor cDNAs of CRH (prepro-CRH) and of ACTH (proopiomelanocortin; POMC) in an Australian marsupial, the fat-tailed dunnart (Sminthopsis crassicaudata)...
September 5, 2017: Gene
https://www.readbyqxmd.com/read/28584120/correction-for-pearce-et-al-variation-in-the-%C3%AE-endorphin-oxytocin-and-dopamine-receptor-genes-is-associated-with-different-dimensions-of-human-sociality
#16
(no author information available yet)
No abstract text is available yet for this article.
June 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28580520/enzyme-immunoassay-of-antibodies-to-endogenous-bioregulators-for-evaluating-the-risk-of-heart-disease
#17
V S Morozova, S N Petrochenko, M A Myagkova, S O Bachurin
The levels of natural antibodies to β-endorphin, bradykinin, histamine, dopamine, and serotonin were measured in 271 cardiological patients in order to evaluate the severity of their clinical status. The patients were distributed into groups differing by the course of the pathological process. The levels of natural antibodies to all antigens were maximum in patients with cardiosclerosis: the content of antibodies to β-endorphin surpassed the control by 46%, to histamine by 62%, to bradykinin by 36%, to dopamine by 49%, and to serotonin by 65%...
June 5, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28554003/opioids-and-opioid-receptors-orchestrate-wound-repair
#18
Ying Wang, Mihir Gupta, Tasneem Poonawala, Mariya Farooqui, Yunfang Li, Fei Peng, Sheldon Rao, Michael Ansonoff, John E Pintar, Kalpna Gupta
We have previously shown that topical opioids including morphine and its congeners promote healing of full thickness ischemic wounds in rats. We examined the contribution of mu opioid receptor (MOPr)-mediated healing of full thickness ischemic wounds using MOPr and delta or kappa opioid receptor knockout (KO) mice. Wound closure in the early (day 5) as well as later phases was delayed in topical morphine or PBS-treated MOPr-KO mice compared with reciprocal treatments of wounds in wild-type (WT) mice. MOPr expression was significantly upregulated at 30 min in the wound margins and colocalized with wound margins and vasculature in the epidermal and dermal layers of the skin...
July 2017: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/28545527/what-intrinsic-factors-influence-responsiveness-to-acupuncture-in-pain-a-review-of-pre-clinical-studies-that-used-responder-analysis
#19
Yu-Kang Kim, Ji-Yeun Park, Seung-Nam Kim, Mijung Yeom, Seungmin Lee, Ju-Young Oh, Hyangsook Lee, Younbyoung Chae, Dae-Hyun Hahm, Hi-Joon Park
BACKGROUND: Not many studies have investigated individual sensitivity to acupuncture. To explore the intrinsic factors related to individual responses to acupuncture, we reviewed published pre-clinical studies using responder analysis on pain. METHODS: We searched the PubMed and EMBASE databases to June 2015. We included pre-clinical reports describing responders and non-responders to anti-nociceptive and analgesic effects of acupuncture in animal study. We identified the potential intrinsic factors which might be related with the response to acupuncture...
May 25, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28538378/effects-of-intensive-training-on-menstrual-function-and-certain-serum-hormones-and-peptides-related-to-the-female-reproductive-system
#20
Geum Joon Cho, Sung Won Han, Jung-Ho Shin, Tak Kim
The aim of this study was to assess the effects of intensive training on menstrual function and related serum hormones and peptides.Forty female participants who attended a training course for an officer at the Korea Third Military Academy, and had regular menstrual periods were enrolled. Menstrual questionnaires and fasting blood samples were collected before entry and at 4-week intervals for 8 weeks. The levels of corticotropin-releasing hormone (CRH), cortisol, prolactin, endorphin-β, neuropeptide Y (NPY), leptin, orexin-A, ghrelin, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), thyrotropin (TSH), and thyroxine (T4) were determined...
May 2017: Medicine (Baltimore)
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