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https://www.readbyqxmd.com/read/28218955/antihyperglycemiac-action-of-diosmin-a-citrus-flavonoid-is-induced-through-endogenous-%C3%AE-endorphin-in-type-i-like-diabetic-rats
#1
Chia-Chen Hsu, Mang Hung Lin, Juei Tang Cheng, Ming Chang Wu
Diosmin is one of the flavonoids contained in citrus and has been demonstrated to improve glucose metabolism in diabetic disorders. However, the mechanism(s) of diosmin in glucose regulation remain obscure. Therefore, we investigated the potential mechanism(s) for the antihyperglycemic action of diosmin in streptozotocin-induced diabetic rats (STZ-diabetic rats). Diosmin lowered hyperglycemia in a dose-dependent manner in STZ-diabetic rats. This action was inhibited by naloxone at a dose sufficient to block opioid receptors...
February 20, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28214095/whether-preventive-low-dose-magnesium-sulphate-infusion-has-an-influence-on-postoperative-pain-perception-and-the-level-of-serum-beta-endorphin-throughout-the-total-abdominal-hysterectomy
#2
K Haryalchi, M Abedinzade, K Khanaki, M M Ghanaie, F M Zadeh
OBJECTIVE: Due to the known role of preventive low dose magnesium sulphate on postoperative pain management, in this randomized, double-blinded, placebo-controlled study, we tried to investigate the possible relationship between low dose intra-operative magnesium sulphate infusion, postoperative analgesia and the level of serum beta-endorphin during total abdominal hysterectomy under general anesthesia. METHODS: Forty women undergoing total abdominal hysterectomy were randomly allocated into 2 groups (20 in each arm)...
February 14, 2017: Revista Española de Anestesiología y Reanimación
https://www.readbyqxmd.com/read/28202578/p38%C3%AE-mapk-signaling-mediates-exenatide-stimulated-microglial-%C3%AE-endorphin-expression
#3
Hai-Yun Wu, Xiao-Fang Mao, Hui Fan, Yong-Xiang Wang
Upon recent discovery, it has been established that activation of glucagon-like peptide-1 receptors (GLP-1Rs) exhibits neuroprotection and antinociception through microglial β-endorphin expression. This study aims to explore its underlying signaling mechanisms. GLP-1Rs and β-endorphin were co-expressed in primary cultures of microglia. Treatment with the GLP-1R agonist exenatide concentration-dependently stimulated microglial expression of the β-endorphin precursor gene POMC and peptide, with EC50 values of 4...
February 15, 2017: Molecular Pharmacology
https://www.readbyqxmd.com/read/28191278/impact-of-yoga-and-meditation-on-cellular-aging-in-apparently-healthy-individuals-a-prospective-open-label-single-arm-exploratory-study
#4
Madhuri Tolahunase, Rajesh Sagar, Rima Dada
This study was designed to explore the impact of Yoga and Meditation based lifestyle intervention (YMLI) on cellular aging in apparently healthy individuals. During this 12-week prospective, open-label, single arm exploratory study, 96 apparently healthy individuals were enrolled to receive YMLI. The primary endpoints were assessment of the change in levels of cardinal biomarkers of cellular aging in blood from baseline to week 12, which included DNA damage marker 8-hydroxy-2'-deoxyguanosine (8-OH2dG), oxidative stress markers reactive oxygen species (ROS), and total antioxidant capacity (TAC), and telomere attrition markers telomere length and telomerase activity...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28183072/alternative-therapies-for-excoriation-skin-picking-disorder-a-brief-update
#5
Julio Torales, Iván Barrios, Jorge Villalba
Context • Excoriation (skin picking) disorder is characterized by the need or urge to pick, scratch, pinch, touch, rub, scrub, squeeze, bite, or dig the skin, and it can be a perplexing condition for the inexperienced physician. Treatments include pharmacotherapy, psychotherapy, and alternative therapies. Alternative therapies for excoriation disorder and other body-focused repetitive behaviors include yoga, aerobic exercise, acupuncture, biofeedback, hypnosis, and inositol and N-acetylcysteine, among others...
January 2017: Advances in Mind-body Medicine
https://www.readbyqxmd.com/read/28173961/a-screen-for-modulators-reveals-that-orexin-a-rapidly-stimulates-thyrotropin-releasing-hormone-expression-and-release-in-hypothalamic-cell-culture
#6
Antonieta Cote-Vélez, Anabel Martínez Báez, Leticia Lezama, Rosa María Uribe, Patricia Joseph-Bravo, Jean-Louis Charli
In the paraventricular nucleus of the mammalian hypothalamus, hypophysiotropic thyrotropin releasing hormone (TRH) neurons integrate metabolic information and control the activity of the thyroid axis. Additional populations of TRH neurons reside in various hypothalamic areas, with poorly defined connections and functions, albeit there is evidence that some may be related to energy balance. To establish extracellular modulators of TRH hypothalamic neurons activity, we performed a screen of neurotransmitters effects in hypothalamic cultures...
February 2, 2017: Neuropeptides
https://www.readbyqxmd.com/read/28154332/a-new-pain-regulatory-system-via-the-brain-long-chain-fatty-acid-receptor-gpr40-ffa1-signal
#7
Kazuo Nakamoto
 An increasingly large number of pharmacological and physiological works on fatty acids have shown that the functional properties of fatty acids are regulated by the amount of individual fatty acid intake and the distribution of fatty acids among organs. Recently, it has been determined that G-protein-coupled receptor 40/free fatty acid receptor 1 (GPR40/FFA1) is activated by long-chain fatty acids, such as docosahexaenoic acid (DHA). GPR40/FFA1 is mainly expressed in the β cell of the pancreas, spinal cord and brain...
2017: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
https://www.readbyqxmd.com/read/28152530/the-preventive-effect-of-coffee-compounds-on-dermatitis-and-epidermal-pigmentation-after-ultraviolet-irradiation-in-mice
#8
Yurika Yamate, Keiichi Hiramoto, Eisuke F Sato
BACKGROUND: Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear. METHODS: C57BL/6j male mice were irradiated with UVB (1.0 kJ/m2/day) for 3 days. Five days after the final session of UVB irradiation, the dorsal skin, ear epidermis, and blood samples were analyzed to investigate the inflammatory factors, melanogenesis factors and related hormones...
February 3, 2017: Skin Pharmacology and Physiology
https://www.readbyqxmd.com/read/28144938/immunocytochemical-identification-and-ontogeny-of-adenohypophyseal-cells-in-a-cave-fish-phreatichthys-andruzzii-cypriniformes-cyprinidae
#9
G Grandi, M Pezzi, M G Marchetti, M Chicca
The morphogenesis of the pituitary gland and the chronological appearance of adenohypophyseal cells were investigated for the first time in the Somalian cave fish Phreatichthys andruzzii by immunocytochemistry. The adult adenohypophysis contained: a rostral pars distalis, with prolactin (PRL) cells arranged in follicles and adrenocorticotropic (ACTH) cells, a proximal pars distalis with somatotropic (GH), β-thyrotropic (TSH), β-gonadotropic type I (FSH) and type II (LH) cells and a pars intermedia with α-somatolactin (SL), α-melanotropic (MSH) and β-endorphin (END) cells...
February 1, 2017: Journal of Fish Biology
https://www.readbyqxmd.com/read/28125980/effect-of-combined-music-and-touch-intervention-on-pain-response-and-%C3%AE-endorphin-and-cortisol-concentrations-in-late-preterm-infants
#10
Jie Qiu, Yun-Fei Jiang, Fang Li, Qian-Hong Tong, Hui Rong, Rui Cheng
BACKGROUND: Preterm neonates undergo many painful procedures as part of their standard care in the neonatal intensive care unit. However, pain treatment is inadequate in many of these routine procedures. In the present study, we investigated the impact and mechanism of combined music and touch intervention (CMT) on the pain response in premature infants. METHODS: Sixty-two preterm neonates (gestational age of <37 weeks) were randomly assigned to either the experimental or control group...
January 26, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28107753/role-of-central-opioid-on-the-antinociceptive-effect-of-sulfated-polysaccharide-from-the-red-seaweed-solieria-filiformis-in-induced-temporomandibular-joint-pain
#11
Ianna Wivianne Fernandes Araújo, Hellíada Vasconcelos Chaves, José Mário Pachêco, Danielle Rocha Val, Lorena Vasconcelos Vieira, Rodrigo Santos, Raul Sousa Freitas, Renata Line Rivanor, Valdécio Silvano Monteiro, Juliana Trindade Clemente-Napimoga, Mirna Marques Bezerra, Norma Maria Barros Benevides
This study aimed to investigate the effect of sulfated polysaccharide from red seaweed Solieria filiformis (Fraction F II) in the inflammatory hypernociception in the temporomandibular joint (TMJ) of rats. Male Wistar rats were pretreated (30min) with a subcutaneous injection (s.c.) of vehicle or FII (0.03, 0.3 or 3.0mg/kg) followed by intra-TMJ injection of 1.5% Formalin or 5-hydroxytryptamine (5-HT, 225μg/TMJ). In other set of experiments rats were pretreated (15min) with an intrathecal injection of the non-selective opioid receptors Naloxone, or μ-opioid receptor antagonist CTOP, or δ-opioid receptor Naltridole hydrochloride, or κ-opioid receptor antagonist Nor-Binaltorphimine (Nor-BNI) followed by injection of FII (s...
January 17, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28094875/neuroendocrinology-of-mast-cells-challenges-and-controversies
#12
REVIEW
Theoharis C Theoharides
Mast cells (MC) are hemopoietically-derived tissue immune cells that are ubiquitous in the body, including neuroendocrine organs such as the hypothalamus, pineal, pituitary, ovaries, pancreas and uterus where their action is not well understood. Mast cells have historically been associated with allergies because of their rich content of histamine and tryptase, but more recently with regulation of immunity and inflammation due their synthesis and release of numerous cytokines and chemokines. Mast cells are located perivascularly and express numerous receptors for diverse ligands such as allergens, pathogens, neurotransmitters, neuropeptides and hormones including acetylcholine, calcitonin gene-related peptide (CGRP), corticosteroids, corticotropin-releasing hormone (CRH), β-endorphin, epinephrine, 17β-estradiol, gonadotrophins, hemokinin-A (HKA), leptin, melatonin, neurotensin (NT), parathyroid hormone (PTH), substance P (SP) and vasoactive instestinal peptide (VIP)...
January 17, 2017: Experimental Dermatology
https://www.readbyqxmd.com/read/28092646/ex-vivo-nonviral-gene-delivery-of-%C3%AE-opioid-receptor-to-attenuate-cancer-induced-pain
#13
Seiichi Yamano, Chi T Viet, Dongmin Dang, Jisen Dai, Shigeru Hanatani, Tadahiro Takayama, Hironori Kasai, Kentaro Imamura, Ron Campbell, Yi Ye, John C Dolan, William Myung Kwon, Stefan D Schneider, Brian L Schmidt
Virus-mediated gene delivery shows promise for the treatment of chronic pain. However, viral vectors have cytotoxicity. To avoid toxicities and limitations of virus-mediated gene delivery, we developed a novel nonviral hybrid vector: HIV-1 Tat peptide sequence modified with histidine and cysteine residues combined with a cationic lipid. The vector has high transfection efficiency with little cytotoxicity in cancer cell lines including HSC-3 (human tongue squamous cell carcinoma) and exhibits differential expression in HSC-3 (∼45-fold) relative to HGF-1 (human gingival fibroblasts) cells...
February 2017: Pain
https://www.readbyqxmd.com/read/28075583/amyloid-fibril-polymorphism-almost-identical-on-the-atomic-level-mesoscopically-very-different
#14
Carolin Seuring, Joeri Verasdonck, Philippe Ringler, Riccardo Cadalbert, Henning Stahlberg, Anja Böckmann, Beat H Meier, Roland Riek
Amyloid polymorphism of twisted and straight β-endorphin fibrils was studied by negative-stain transmission electron microscopy, scanning transmission electron microscopy, and solid-state nuclear magnetic resonance spectroscopy. Whereas fibrils assembled in the presence of salt formed flat, striated ribbons, in the absence of salt they formed mainly twisted filaments. To get insights into their structural differences at the atomic level, 3D solid-state NMR spectra of both fibril types were acquired, allowing the detection of the differences in chemical shifts of (13)C and (15)N atoms in both preparations...
February 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28067354/heparin-acts-as-a-structural-component-of-%C3%AE-endorphin-amyloid-fibrils-rather-than-a-simple-aggregation-promoter
#15
N Nespovitaya, P Mahou, R F Laine, G S Kaminski Schierle, C F Kaminski
The aggregation promoter heparin is commonly used to study the aggregation kinetics and biophysical properties of protein amyloids. However, the underlying mechanism for amyloid promotion by heparin remains poorly understood. In the case of the neuropeptide β-endorphin that can reversibly adopt a functional amyloid form in nature, aggregation in the presence of heparin leads to a loss of function. Applying correlative optical super-resolution microscopy methods, we show that heparin incorporates into emerging β-endorphin fibrils forming an integral component and is essential for amyloid templating...
January 19, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/28063803/tamoxifen-and-ici-182-780-activate-hypothalamic-g-protein-coupled-estrogen-receptor-1-to-rapidly-facilitate-lordosis-in-female-rats
#16
Nathan Long, Bertha Long, Asma Mana, Dream Le, Lam Nguyen, Sima Chokr, Kevin Sinchak
In the female rat, sexual receptivity (lordosis) can be facilitated by sequential activation of estrogen receptor (ER) α and G protein-coupled estrogen receptor 1 (GPER) by estradiol. In the estradiol benzoate (EB) primed ovariectomized (OVX) rat, EB initially binds to ERα in the plasma membrane that complexes with and transactivates metabotropic glutamate receptor 1a to activate β-endorphin neurons in the arcuate nucleus of the hypothalamus (ARH) that project to the medial preoptic nucleus (MPN). This activates MPN μ-opioid receptors (MOP), inhibiting lordosis...
January 4, 2017: Hormones and Behavior
https://www.readbyqxmd.com/read/28049076/olfactory-identification-in-patients-with-schizophrenia%C3%A2-%C3%A2-the-influence-of-%C3%AE-endorphin-and-calcitonin-gene-related-peptide-concentrations
#17
M Urban-Kowalczyk, J Śmigielski, D Strzelecki
BACKGROUND: The relationship between the olfactory system and emotional processing is an area of growing interest in schizophrenia research. Both the orbitofrontal cortex and amygdala are involved in the processing of olfactory information, and olfactory deficits may be also influenced by endogenous opioids and calcitonin gene-related peptide (CGRP), which is probably involved in dopaminergic transmission. However, the relationship between endorphins and dopaminergic transmission has not been fully explored...
December 29, 2016: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28039905/ultraviolet-a-eye-irradiation-ameliorates-colon-carcinoma-induced-by-azoxymethane-and-dextran-sodium-sulfate-through-%C3%AE-endorphin-and-methionine-enkephalin
#18
Keiichi Hiramoto, Satoshi Yokoyama, Yurika Yamate
BACKGROUND: We previously reported that ultraviolet (UV) A eye irradiation reduces the ulcerative colitis induced by dextran sodium sulfate (DSS). This study examined the effects of UVA on colon carcinoma induced by azoxymethane (AOM) and DSS. METHODS: We irradiated the eyes of ICR mice with UVA at a dose of 110 kJ/m(2) using an FL20SBLB-A lamp for the experimental period. RESULTS: In mice treated with these drugs, the symptom of colon carcinoma was reduced by UVA eye irradiation...
December 31, 2016: Photodermatology, Photoimmunology & Photomedicine
https://www.readbyqxmd.com/read/28002791/chinese-herb-cinobufagin-reduced-cancer-pain-is-associated-with-increased-peripheral-opioids-by-invaded-cd3-4-8-lymphocytes
#19
Tao Chen, Shenjun Yuan, Xin-Nian Wan, Ling Zhan, Xue-Qin Yu, Jian-Hong Zeng, Hong Li, Wen Zhang, Xiang-Yang Hu, Yi-Fei Ye, Wei Hu
OBJECTIVES: To investigate the mechanism of cinobufagin-reduced cancer pain in mouse cancer pain model and in vitro cell co-culture system. METHODS: Female Kunming mice were randomly divided into 4 groups. One group of animals was set as normal control without any treatment. Other three groups of animals received H22 hepatoma cell inoculation in right hind paw. At day 9 after inoculation, mice in other three groups were injected intraperitoneally once a day for 8 days with the solvent, morphine or cinobufagin, respectively...
December 17, 2016: Oncotarget
https://www.readbyqxmd.com/read/27941132/health-outcomes-of-a-series-of-bonny-method-of-guided-imagery-and-music-sessions-a-systematic-review
#20
Cathy H McKinney, Timothy J Honig
BACKGROUND: The Bonny Method of Guided Imagery and Music (GIM) is a music-centered approach to exploring consciousness for personal growth and transformation. Applications have been reported in a variety of clinical and nonclinical contexts. OBJECTIVE: The purpose of this study was to review evidence that a series of Bonny Method of GIM sessions may promote positive health outcomes in adults. METHODS: This systematic review examined randomized and nonrandomized controlled trials and repeated measures designs that reported psychological or physiological outcomes following a series of at least six individual Bonny Method of GIM sessions...
December 8, 2016: Journal of Music Therapy
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