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Growth Hormone and aging

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https://www.readbyqxmd.com/read/29455533/effect-of-dietary-protein-level-on-the-expression-of-proteins-in-the-gastrointestinal-tract-of-young-pigs
#1
Xianyong Ma, Xianyong Ma, Zhimei Tian, Dun Deng, Yiyan Cui, Yueqin Qiu
The objective of this research is to investigate the effect of protein level on proteins expression in the gastrointestinal tract of young pigs. Eighteen piglets (Duroc×Landrace×Yorkshire) were weaned at 28 days of age and randomly assigned to 3 diets with 20%, 17%, and 14% CP level and four essential AA: Lys, Met, Thr and Trp in three diets meet the requirements of weaned piglets. The experimental period lasts 45d. RESULTS: Compared with the control (20% CP level), the average daily feed intake, the average daily gain and gain feed ratio of the 17% CP group did not decrease (P > 0...
February 17, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29455392/the-psychometric-evaluation-of-the-quality-of-life-in-short-stature-youth-qolissy-instrument-for-german-children-born-small-for-gestational-age
#2
R Sommer, J Blömeke, M Bullinger, J Quitmann
PURPOSE: This study aimed to validate the disease-specific "quality of life in short stature youth (QoLISSY)-instrument" that assessesQuery the health-related quality of life (HrQoL) in German children and adolescents diagnosed as small for gestational age (SGA) in a patient and parent report. METHODS: The psychometric performance of the German version of the QoLISSY questionnaire was examined in terms of reliability and validity in 65 SGA families (17 child reports/64 parent reports) and compared to the psychometric performance of the original European QoLISSY dataset of over 200 children with growth hormone deficiency and idiopathic short stature (ISS)...
February 17, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29453937/trajectory-classes-of-cannabis-use-and-heavy-drinking-among-rural-african-american-adolescents-multilevel-predictors-of-class-membership
#3
Allen W Barton, Gene H Brody, Tamika C B Zapolski, Trenette C Goings, Steven M Kogan, Michael Windle, Tianyi Yu
AIMS: To inform research on the etiology and prevention of substance use among rural African American youth by (a) identifying developmental trajectory classes of cannabis use and heavy drinking across adolescence and young adulthood, and (b) examining associations between trajectory class membership and multi-level assessments of risk factors. DESIGN: A prospective study spanning nine years with assessments of cannabis use and heavy drinking, the catecholamines epinephrine and norepinephrine, perceived stress, and psychosocial risk factors...
February 17, 2018: Addiction
https://www.readbyqxmd.com/read/29452885/somatolactogens-and-diabetic-retinopathy
#4
REVIEW
Kevin Christian Bermea, Alejandro Rodríguez-García, Andrew Tsin, Hugo Alberto Barrera-Saldaña
IMPORTANCE: Diabetic retinopathy (DR) is one of the most common of all diabetic complications. The number of people with DR in the United States is expected to increase to 16 million by 2050. DR is the leading cause of blindness among working-age adults in many different countries, including the United States. In later DR stages, neovascularization is associated with extensive retinal capillary non-perfusion and vitreo-proliferation leading to retinal detachment. This neovascularization is orchestrated by an imbalance of growth factors in the retina from which somatolactogens (pituitary growth hormone, GH-N; placental growth hormone, GH-V; prolactin, PRL; and placental lactogen, PL, also referred as chorionic somatomammotropin, CSH), may play an important role...
February 6, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29451226/final-adult-height-and-endocrine-complications-in-young-adults-with-%C3%AE-thalassemia-major-tm-who-received-oral-iron-chelation-oic-in-comparison-with-those-who-did-not-use-oic
#5
Ashraf T Soliman, Mohamed A Yassin, Vincenzo De Sanctis
BACKGROUND: Relatively little is known about endocrine function, bone mineral health, and growth during oral iron chelation therapy in β-thalassemia major patients (TM) on treatment with deferasirox. AIMS OF THE STUDY: To study the frequency of endocrine complications, IGF-1 levels and final adult standing height (FA-Ht) in patients with BTM in two groups of adult patients. PATIENTS AND METHODS: The first group (Group A; 15 patients, 6 females and 9 males) received oral iron chelation therapy (OIC) with deferasirox for 6 years before puberty; the second group (Group B;40 patients) attained the FA-Ht before the use of OIC (iron chelation therapy with deferoxamine (DFO) given subcutaneously, since the age of 2 years)...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29448132/%C3%AE-calpain-capn1-calpastatin-cast-and-growth-hormone-receptor-ghr-genetic-effects-on-angus-beef-heifer-performance-traits-and-reproduction
#6
Richard G Tait, Robert A Cushman, Anthony K McNeel, Eduardo Casas, Timothy P L Smith, Harvey C Freetly, Gary L Bennett
Genetic marker effects and type of inheritance are estimated with poor precision when minor marker allele frequencies are low. An Angus population was subjected to marker assisted selection for multiple years to equalize CAPN1 haplotypes, CAST, and GHR genetic marker frequencies. The objective was to estimate the pleiotropic effects of these carcass quality oriented markers for body weight, reproduction, and first calf performance traits in 174 replacement beef females which were managed under 2 post-weaning development protocols...
February 3, 2018: Theriogenology
https://www.readbyqxmd.com/read/29446837/25-oh-vitamin-d-parathyroid-hormone-and-calcium-serum-levels-in-captive-common-marmosets-callithrix-jacchus-reference-values-and-effect-of-age-sex-season-and-closure-of-long-bone-epiphyses
#7
Leslie Bosseler, Jaco Bakker, Luc Duchateau, Ed Remarque, Jan A M Langermans, Pieter Cornillie, Koen Chiers
BACKGROUND: To date, reference values for 25-OH-vitamin D, parathyroid hormone (PTH), and calcium in serum of common marmosets (Callithrix jacchus) based on a large sample size are not available. METHODS: Serum reference values for these parameters were determined and correlated with sex, age, season of sampling, and time of long bone epiphyseal closure in captive-housed marmosets. RESULTS AND CONCLUSIONS: The 90% reference range for serum 25-OH-vitamin D is 47...
February 15, 2018: Journal of Medical Primatology
https://www.readbyqxmd.com/read/29445356/dhea-supplementation-confers-no-additional-benefit-to-that-of-growth-hormone-on-pregnancy-and-live-birth-rates-in-ivf-patients-categorized-as-poor-prognosis
#8
Kevin N Keane, Peter M Hinchliffe, Philip K Rowlands, Gayatri Borude, Shanti Srinivasan, Satvinder S Dhaliwal, John L Yovich
Background: In vitro fertilization (IVF) patients receive various adjuvant therapies to enhance success rates, but the true benefit is actively debated. Growth hormone (GH) and dehydroepiandrosterone (DHEA) supplementation were assessed in women undergoing fresh IVF transfer cycles and categorized as poor prognosis from five criteria. Methods: Data were retrospectively analyzed from 626 women undergoing 626 IVF cycles, where they received no adjuvant, GH alone, or GH-DHEA in combination...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29444670/breast-cancer-in-ethiopia-evidence-for-geographic-difference-in-the-distribution-of-molecular-subtypes-in-africa
#9
Endale Hadgu, Daniel Seifu, Wondemagegnhu Tigneh, Yonas Bokretsion, Abebe Bekele, Markos Abebe, Thomas Sollie, Sofia D Merajver, Christina Karlsson, Mats G Karlsson
BACKGROUND: Breast cancer is a heterogeneous disease with several morphological and molecular subtypes. Widely accepted molecular classification system uses assessment of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and proliferation marker Ki67. Few studies have been conducted on the incidence and molecular types of breast cancer in Sub-Saharan Africa. Previous studies mainly from Western and Central Africa, showed breast cancer to occur at younger ages and to present with aggressive features, such as high-grade, advanced stage and triple-negative phenotype (negative for ER, PR and HER2)...
February 14, 2018: BMC Women's Health
https://www.readbyqxmd.com/read/29444092/the-impact-of-early-life-nutrition-and-housing-on-growth-and-reproduction-in-dairy-cattle
#10
G Curtis, C McGregor Argo, D Jones, D Grove-White
Contentious issues in calf rearing include milk feeding practices and single versus group housing. The current study was performed on a high producing 170 Holstein cow dairy farm, to investigate the impact of nutrition and housing on growth and reproduction. Heifer calves (n = 100) were allocated in birth order to one of two commonly used management strategies. All calves received 3-4 litres of dam specific colostrum within 6 hours of birth. Group A calves were group housed from birth and fed milk replacer (MR) ad libitum via a computerised machine utilising a single teat, with weaning commencing at 63 days of age...
2018: PloS One
https://www.readbyqxmd.com/read/29443755/argininemia-as-a-cause-of-severe-chronic-stunting-and-partial-growth-hormone-deficiency-pghd-a-case-report
#11
Xiaotang Cai, Dan Yu, Yongmei Xie, Hui Zhou
RATIONALE: Argininemia is an autosomal recessive inherited disorder of the urea cycle. Because of its atypical symptoms in early age, diagnosis can be delayed until the typical chronic manifestations - including spastic diplegia, deterioration in cognitive function, and epilepsy - appear in later childhood. PATIENT CONCERNS: A Chinese boy initially presented with severe stunting and partial growth hormone deficiency (PGHD) at 3 years old and was initially treated with growth hormone replacement therapy...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29434339/epidemiology-and-biomarker-profile-of-pituitary-adenohypophysial-tumors
#12
Ozgur Mete, Amber Cintosun, Irwin Pressman, Sylvia L Asa
Recent studies have reported the prevalence of pituitary tumors to be ~1/1000 population. Many are prolactin-producing tumors that are managed medically, however, the epidemiology of surgically resected pituitary adenohypophysial neuroendocrine tumors has not been reported in a large series with detailed characterization. We reviewed 1055 adenohypophysial tumors from 1169 transsphenoidal resections from the pathology files of University Health Network, Toronto, 2001-2016. Tumors were characterized by immunohistochemical localization of transcription factors (Pit-1, ERα, SF-1, Tpit), hormones (adrenocorticotropin, growth hormone, prolactin, β-thyrotropin, β-folliculotropin, β-luteotropin, α-subunit), and other biomarkers (keratins, Ki67, p27, FGFR4)...
February 12, 2018: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/29433861/metabolic-profile-of-children-with-extrahepatic-portal-vein-obstruction-undergoing-meso-rex-bypass
#13
Timothy B Lautz, Simon Eaton, Lisa Keys, Joy Ito, Mario Polo, Jonathan C K Wells, Agostino Pierro, Riccardo A Superina
BACKGROUND: Extrahepatic portal vein obstruction (EHPVO) in children is often associated with growth restriction, which improves after the restoration of portal venous flow with a meso-Rex bypass, but the physiologic mechanism is unknown. The purpose of this study was to investigate the mechanism of growth delay in children with EHPVO by detailing the metabolic and nutritional profile before and after meso-Rex bypass. METHODS: Twenty consecutive children with EHPVO were prospectively studied before and 1 year after meso-Rex bypass...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29433573/design-of-the-growth-hormone-deficiency-and-efficacy-of-treatment-get-score-and-non-interventional-proof-of-concept-study
#14
Peter H Kann, Simona Bergmann, Martin Bidlingmaier, Christina Dimopoulou, Birgitte T Pedersen, Günter K Stalla, Matthias M Weber, Stefanie Meckes-Ferber
BACKGROUND: The adverse effects of growth hormone (GH) deficiency (GHD) in adults (AGHD) on metabolism and health-related quality of life (HRQoL) can be improved with GH substitution. This investigation aimed to design a score summarising the features of GHD and evaluate its ability to measure the effect of GH substitution in AGHD. METHODS: The Growth hormone deficiency and Efficacy of Treatment (GET) score (0-100 points) assessed (weighting): HRQoL (40%), disease-related days off work (10%), bone mineral density (20%), waist circumference (10%), low-density lipoprotein cholesterol (10%) and body fat mass (10%)...
February 13, 2018: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/29428703/the-contribution-of-total-and-free-iodothyronines-to-welfare-maintenance-and-management-stress-coping-in-ruminants-and-equines-physiological-ranges-and-reference-values
#15
REVIEW
Adriana Ferlazzo, Cristina Cravana, Esterina Fazio, Pietro Medica
In order to acquire a pattern of thyroid involvement in welfare maintenance in Ruminants and Equines, this review summarizes data concerning the reference values of total and free iodothyronines and their modifications in physiological conditions and in different management conditions (pregnancy, lactation, weaning, growth, isolation, restraint, shearing, confinement and transportation). Thyroidal and extrathyroidal tissues efficiently respond to management practices, giving a differentiated contribution to circulating iodothyronine changes...
February 2, 2018: Research in Veterinary Science
https://www.readbyqxmd.com/read/29425110/a-japanese-patient-with-congenital-central-hypothyroidism-caused-by-a-novel-igsf1-mutation
#16
Takeshi Yamaguchi, Tomoyuki Hothubo, Shuntaro Morikawa, Akie Nakamura, Toshihiko Mori, Toshihiro Tajima
BACKGROUND: IGSF1 abnormality causes diverse symptoms, including congenital central hypothyroidism (CCH), prolactin hyposecretion, testicular enlargement and delayed puberty. CASE PRESENTATION: Here, we report a case of a male patient who visited our hospital with a chief complaint of abdominal pain and short stature, in whom we identified a novel IGSF1 mutation. He was closely examined because of chronic constipation since infancy, persistent abdominal pain at 14 years of age and marked short stature (-4...
February 9, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29423669/normative-data-of-thyroid-gland-volume-in-south-indian-neonates-and-infants
#17
Sudha Rathna Prabhu, Shriraam Mahadevan, Sujatha Jagadeesh, Dharani Dharan, Chandra Ganesh, Seshadri Suresh, Indrani Suresh
OBJECTIVE: To establish normative ultrasound data for thyroid gland volume in South Indian neonates and infants and compare with abnormal sonological features of thyroid in congenital hypothyroidism (CH) to explore thyroid ultrasound utility as a supportive screening tool to newborn screening programs for early detection of CH. METHODS: In view of impact of geo ethnic factors, varying growth velocities and body mass indices of human population worldwide, specific regional, age and gender related reference data for thyroid gland size and volume are vital...
February 9, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29423542/evaluation-of-growth-hormone-response-to-ghrh-plus-arginine-test-in-children-with-idiopathic-short-stature-role-of-peak-time
#18
M Castagno, A Monzani, S Zanetta, G Genoni, E Giglione, R Ricotti, G Bona, F Prodam, S Bellone
PURPOSE: To describe the course of growth hormone response to growth hormone releasing hormone (GHRH) plus arginine provocative test in children with idiopathic short stature (ISS) and to evaluate the role of peak time. METHODS: A retrospective study was performed analyzing 344 GHRH plus arginine provocative tests performed in children and adolescents with short stature. Serum GH levels were measured at four-time points (T0', T30', T45' and T60') and GH peak was defined as the maximum value at any time point...
February 8, 2018: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/29420022/the-transcriptomics-related-mechanisms-of-supplementing-laying-broiler-breeder-hens-with-dietary-daidzein-to-improve-the-immune-function-and-growth-performance-of-offspring
#19
Hao Fan, Zengpeng Lv, Liping Gan, Yuming Guo
Daidzein (DA) is an isoflavone that is primarily extracted from soy plants. This study evaluated the effects of supplementing laying broiler breeder hens with dietary DA on the immune function and growth performance of their offspring and the underlying mechanism. A total of 720 breeders were divided into 3 treatment groups that were fed either a control diet (CON), a DA-low-supplemented diet (DLS, CON+20 mg/kg DA) or a DA-high-supplemented diet (DHS, CON+100 mg/kg DA) for 8 weeks, eggs were collected for hatching during the final week...
February 8, 2018: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29412390/growth-hormone-deficiency-with-advanced-bone-age-phenotypic-interaction-between-ghrh-receptor-and-cyp21a2-mutations-diagnosed-by-sanger-and-whole-exome-sequencing
#20
Fernanda A Correa, Marcela M França, Qing Fang, Qianyi Ma, Tania A Bachega, Andresa Rodrigues, Bilge A Ozel, Jun Z Li, Berenice B Mendonca, Alexander A L Jorge, Luciani R Carvalho, Sally A Camper, Ivo J P Arnhold
Isolated growth hormone deficiency (IGHD) is the most common pituitary hormone deficiency and, clinically, patients have delayed bone age. High sequence similarity between CYP21A2 gene and CYP21A1P pseudogene poses difficulties for exome sequencing interpretation. A 7.5 year-old boy born to second-degree cousins presented with severe short stature (height SDS -3.7) and bone age of 6 years. Clonidine and combined pituitary stimulation tests revealed GH deficiency. Pituitary MRI was normal. The patient was successfully treated with rGH...
December 2017: Archives of Endocrinology and Metabolism
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