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Growth Hormone and aging

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https://www.readbyqxmd.com/read/29031192/growth-and-endocrine-function-in-children-with-dravet-syndrome
#1
Krista Eschbach, Sharon Scarbro, Elizabeth Juarez-Colunga, Victoria Allen, Stephanie Hsu, Kelly Knupp
PURPOSE: Dravet syndrome is an intractable childhood epilepsy syndrome most often associated with an SCN1A mutation. In our clinical practice, several patients with Dravet syndrome were noted to have short stature and endocrine dysfunction. This has not been reported in the literature. Our study aim was to describe growth measurements and endocrine abnormalities in children with Dravet syndrome. METHOD: A retrospective chart review was performed at a single institution...
September 29, 2017: Seizure: the Journal of the British Epilepsy Association
https://www.readbyqxmd.com/read/29031189/renal-subcapsular-xenografing-of-human-fetal-external-genital-tissue-a-new-model-for-investigating-urethral-development
#2
Dylan Isaacson, Joel Shen, Mei Cao, Adriane Sinclair, Xuan Yue, Gerald Cunha, Laurence Baskin
In this paper, we introduce our novel renal subcapsular xenograft model for the study of human penile urethral and clitoral development. We grafted fifteen intact fetal penes and clitorides 8-11 weeks fetal age under the renal capsules of gonadectomized athymic mice. The mice were treated with a subcutaneous pellet of dihydrotestosterone (DHT), diethylstilbestrol (DES) or untreated with hormones. Xenografts were harvested after fourteen days of growth and analyzed via serial histologic sectioning and immunostaining for Ki-67, cytokeratins 6, 7 and 10, uroplakin and the androgen receptor...
September 22, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29029193/sex-and-iron-modify-fibroblast-growth-factor-23-fgf23-concentration-in-1-year-old-children
#3
Elisa Holmlund-Suila, Maria Enlund-Cerullo, Saara Valkama, Helena Hauta-Alus, Jenni Rosendahl, Otto Helve, Timo Hytinantti, Heli Viljakainen, Sture Andersson, Outi Mäkitie
Context: Fibroblast growth factor 23 (FGF23) plays an important role in phosphate homeostasis but its regulation is inadequately characterized. Objective: To examine regulators of FGF23, especially sex and iron status, in early childhood. Design: A cross-sectional study involving 1-year-old children. Setting and participants: Healthy term infants with a birth weight appropriate for gestational age were recruited to an ongoing vitamin D trial at the Kätilöopisto Maternity Hospital, Helsinki, Finland...
October 5, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29029099/biomarkers-of-mineral-and-bone-metabolism-and-20-year-risk-for-hospitalization-with-infection-the-aric-study
#4
Junichi Ishigami, Bernard G Jaar, Casey M Rebholz, Morgan E Grams, Erin D Michos, Myles Wolf, Csaba P Kovesdy, Shinichi Uchida, Josef Coresh, Pamela L Lutsey, Kunihiro Matsushita
Context: Mineral and bone disorders (MBD) may be relevant in the etiology of infection. Objective: To determine whether MBD biomarkers were associated with incidence of hospitalization with infection. We also assessed the cross-sectional association between levels of MBD biomarkers and kidney function. Design: Setting, Participants: Community-based cohort study using 11,218 participants with estimated glomerular filtration rate (eGFR) ≥30 ml/min/1...
September 27, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29026873/graft-growth-and-podocyte-dedifferentiation-in-donor-recipient-size-mismatch-kidney-transplants
#5
Janina Müller-Deile, Jan Hinrich Bräsen, Marion Pollheimer, Manfred Ratschek, Hermann Haller, Lars Pape, Mario Schiffer
BACKGROUND: Kidney transplantation is the treatment choice for patients with end-stage renal diseases. Because of good long-term outcome, pediatric kidney grafts are also accepted for transplantation in adult recipients despite a significant mismatch in body size and age between donor and recipient. These grafts show a remarkable ability of adaptation to the recipient body and increase in size in a very short period, presumably as an adaptation to hyperfiltration. METHODS: We investigated renal graft growth as well as glomerular proliferation and differentiation markers Kiel-67, paired box gene 2 and Wilms tumor protein (WT1) expression in control biopsies from different transplant constellations: infant donor for infant recipient, infant donor for child recipient, infant donor for adult recipient, child donor for child recipient, child donor for adult recipient, and adult donor for an adult recipient...
October 2017: Transplantation Direct
https://www.readbyqxmd.com/read/29025670/bone-regeneration-biomaterials-as-local-delivery-systems-with-improved-osteoinductive-properties
#6
REVIEW
Victor Martin, Ana Bettencourt
Bone is a mineralized conjunctive tissue, with a unique trauma healing capability. However, the replacement or regeneration of lost bone is not always successful and becomes more difficult the wider the bone defect. A significant growth in the demand for orthopedic and maxillofacial surgical procedures as a result of population aging and increase in chronic diseases as diabetes is a fact and successful approaches for bone regeneration are still needed. Until today, autogenous bone graft continues to be the best solution even with important limitations, as quantity and the requirement of a donator area...
January 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29025206/nonalcoholic-fatty-liver-disease-in-long-term-survivors-of-childhood-onset-craniopharyngioma
#7
So Yoon Jung, Yun Jeong Lee, Hye Jin Lee, Young Ah Lee, Jin Soo Moon, Jae Sung Ko, Sei Won Yang, Choong Ho Shin
PURPOSE: Hypothalamic obesity in childhood-onset (CO-) craniopharyngioma patients may predispose to nonalcoholic fatty liver disease (NAFLD). This study reviewed the characteristics of NAFLD associated with CO-craniopharyngioma. METHODS: This study retrospectively reviewed 75 patients who underwent surgery for craniopharyngioma while younger than 15 years of age between 2000 and 2016. RESULTS: Elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) above 40 IU/L was observed in 51 of the 75 (68%) CO-craniopharyngioma patients...
September 2017: Annals of Pediatric Endocrinology & Metabolism
https://www.readbyqxmd.com/read/29023765/impact-of-clinicopathological-characteristics-on-the-efficacy-of-neoadjuvant-therapy-in-patients-with-human-epidermal-growth-factor-receptor-2-positive-breast-cancer
#8
Bin Zhao, Hong Zhao
Neoadjuvant therapy has become increasingly common in human epidermal growth factor receptor-2 (HER2)-positive breast cancer. In this study, we examined the impact of different clinicopathological characteristics on pathological complete response (pCR) in patients treated with anti-HER2 agents. The PubMed and Embase databases were searched from inception through April 2017 to identify studies that met pre-specified criteria. The odds ratios (ORs) and 95% confidence intervals (CIs) were extracted directly or were calculated with other available information...
October 11, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29022650/sleep-related-breathing-disorders-in-patients-with-prader-willi-syndrome-depending-on-the-period-of-growth-hormone-treatment
#9
Agnieszka Lecka-Ambroziak, Małgorzata Jędrzejczak, Marta Wysocka-Mincewicz, Mieczysław Szalecki
INTRODUCTION: Sleep-related breathing disorders (SRBD) are commonly present in patients with Prader-Willi syndrome (PWS). Recombinant human growth hormone (rhGH) treatment is reported to improve breathing function in PWS, but the findings are not explicit. MATERIAL AND METHODS: Screening polysomnography- polygraphy (PSG), assessing nasal respiratory flow, respiratory effort, and blood oxygen saturation, was used. Group 1 - before rhGH therapy (n = 11, mean age 3...
October 12, 2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/28993395/single-centre-retrospective-analysis-of-growth-hormone-supplementation-in-ivf-patients-classified-as-poor-prognosis
#10
Kevin N Keane, John L Yovich, Anahita Hamidi, Peter M Hinchliffe, Satvinder S Dhaliwal
BACKGROUND: Patients undergoing in vitro fertilisation (IVF) receive various adjuvant therapies in order to enhance success rates, but the true benefit is actively debated. Growth hormone (GH) supplementation was assessed in poor-prognosis women undergoing fresh IVF transfer cycles. METHODS: Data were retrospectively analysed from 400 IVF cycles, where 161 women received GH and 239 did not. RESULTS: Clinical pregnancy, live birth rates and corresponding ORs and CIs were significantly greater with GH, despite patients being significantly older with lower ovarian reserve...
October 8, 2017: BMJ Open
https://www.readbyqxmd.com/read/28991998/effects-of-feeding-ground-redberry-juniper-juniperus-pinchotii-to-gestating-ewes-on-pre-and-postpartum-performance-serum-metabolites-and-hormones-milk-fatty-acid-composition-and-progeny-preweaning-performance
#11
W C Stewart, T R Whitney, E J Scholljegerdes, D M Hallford, J W Walker, R P Adams, H D Naumann
The objective of this research was to evaluate effects of replacing sorghum × Sudangrass hay with ground juniper in gestating ewe supplements on pre- and postpartum growth performance, serum metabolites and hormonal concentrations, milk fatty acid composition, and progeny preweaning performance. In a completely randomized design, commercial Rambouillet ewes (age = 3 to 5 yr; initial BW = 65.2 ± 1.6 kg) on a base diet of long-stem sorghum × Sudangrass hay were assigned to 1 of 4 dietary supplements in which ground juniper replaced 0% (CNTL), 33% (18JUN), 66% (36JUN), or 100% (54JUN) of the ground sorghum × Sudangrass hay in a pelleted supplement with ground juniper from d 38 ± 4 of gestation to 2 d postpartum...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28991900/intra-individual-variability-and-circadian-rhythm-of-vascular-endothelial-growth-factors-in-subjects-with-normal-glucose-tolerance-and-type-2-diabetes
#12
Markolf Hanefeld, Katrin Engelmann, Dieter Appelt, Dirk Sandner, Ingo Weigmann, Xenia Ganz, Frank Pistrosch, Carsta Köhler, Antje Gasparic, Andreas L Birkenfeld
Increased levels of systemic vascular endothelial growth factors (VEGFs) in patients with diabetes are associated with increased risk of microvessel disease. On the other hand, low VEGF levels after intravitreal antibody application may be associated with acute cardiovascular complications and treatment failure. Individual levels of systemic VEGF vary in a wide range depending on analytical methods and quality of diabetes control. So far only limited information exists on intraindividual fluctuations over longer periods and circadian rhythms...
2017: PloS One
https://www.readbyqxmd.com/read/28990677/left-ventricular-twist-is-impaired-in-acromegaly-insights-from-the-three-dimensional-speckle-tracking-echocardiographic-magyar-path-study
#13
Árpád Kormányos, Péter Domsik, Anita Kalapos, Andrea Orosz, Csaba Lengyel, Zsuzsanna Valkusz, Attila Trencsányi, Tamás Forster, Attila Nemes
INTRODUCTION: Acromegaly is a rare, chronic, disfiguring, and debilitating disease caused, in 90% of cases, by a benign monoclonal growth hormone-secreting pituitary adenoma. The present study aimed to assess left ventricular (LV) rotational and twist mechanics in acromegalic patients and to compare their results to age- and gender-matched healthy controls. METHODS: The present study comprised 24 acromegalic patients, from which 4 were excluded due to insufficient image quality (mean age: 57...
October 9, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/28990127/patterns-of-axillary-evaluation-in-older-patients-with-breast-cancer-and-associations-with-adjuvant-therapy-receipt
#14
Laura S Dominici, Helmneh M Sineshaw, Ahmedin Jemal, Chun Chieh Lin, Tari A King, Rachel A Freedman
PURPOSE: Although axillary lymph node status has traditionally been a key factor in informing adjuvant breast cancer therapy recommendations, this information may be less relevant as our focus shifts more towards tumor biology, particularly in older patients where comorbidity influences treatment decisions and nodal staging and/or surgery may not improve outcomes. We examined patterns of axillary surgery and associations between axillary surgery and receipt of adjuvant treatment in older breast cancer patients...
October 9, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28987236/associations-of-cord-blood-metabolites-with-perinatal-characteristics-newborn-anthropometry-and-cord-blood-hormones-in-project-viva
#15
Wei Perng, Sheryl L Rifas-Shiman, Scott McCulloch, Leda Chatzi, Christos Mantzoros, Marie-France Hivert, Emily Oken
CONTEXT: Metabolomics has emerged as a powerful tool to characterize biomarkers and elucidate physiological processes underlying adverse health outcomes. Little is known of these relationships during gestation and infancy, which are critical period for development of metabolic disease risk. OBJECTIVES: To identify cord blood metabolite patterns associated with birth size; and to investigate relations of the birth size-associated metabolite patterns, and a branched chain amino acid (BCAA) metabolite pattern with a range of newborn and perinatal characteristics...
November 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28986927/effects-of-phyto-oestrogen-quercetin-on-productive-performance-hormones-reproductive-organs-and-apoptotic-genes-in-laying-hens
#16
J X Yang, M T Chaudhry, J Y Yao, S N Wang, B Zhou, M Wang, C Y Han, Y You, Y Li
Quercetin, a polyphenolic flavonoid with diverse biological activities including anti-inflammatory and antiviral, inhibits lipid peroxidation, prevents oxidative injury and cell death. The purpose of the research was to investigate the effect of quercetin on productive performance, reproductive organs, hormones and apoptotic genes in laying hens between 37 and 45 weeks of age, because of the structure and oestrogenic activities similar to 17β-oestradiol. The trial was conducted using 240 Hessian laying hens (37 weeks old), housed in wire cages with two hens in each cage...
October 6, 2017: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/28984256/neonatal-endocrine-labomas-pitfalls-and-challenges-in-reporting-neonatal-hormonal-reports
#17
Sachin Chittawar, Deep Dutta, Deepak Khandelwal, Rajiv Singla
This review highlights pitfalls and challenges in interpreting neonatal hormone reports. Pre-analytical errors contribute to nearly 50% of all errors. Modern chemiluminescence assay are more accurate, have lower risk of Hook's effect, but continue to have problems of assay interference. Liquid chromatography mass spectroscopy is gold standard for most hormone assays. Neonatal hypoglycemia diagnostic cut-offs are lower than adults. Random growth hormone testing is of value in diagnosing growth hormone deficiency in neonates...
September 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/28979927/breast-cancer-risk-factors-in-relation-to-estrogen-receptor-progesterone-receptor-insulin-like-growth-factor-1-receptor-and-ki67-expression-in-normal-breast-tissue
#18
Hannah Oh, A Heather Eliassen, Andrew H Beck, Bernard Rosner, Stuart J Schnitt, Laura C Collins, James L Connolly, Laleh Montaser-Kouhsari, Walter C Willett, Rulla M Tamimi
Studies have suggested that hormone receptor and Ki67 expression in normal breast tissue are associated with subsequent breast cancer risk. We examined the associations of breast cancer risk factors with estrogen receptor (ER), progesterone receptor (PR), insulin-like growth factor-1 receptor (IGF-1R), and Ki67 expression in normal breast tissue. This analysis included 388 women with benign breast disease (ages 17-67 years) in the Nurses' Health Studies. Immunohistochemical staining was performed on tissue microarrays constructed from benign biopsies containing normal breast epithelium and scored as the percentage of epithelial cells that were positively stained...
2017: NPJ Breast Cancer
https://www.readbyqxmd.com/read/28977159/is-fibroblast-growth-factor-23-a-new-cardiovascular-risk-marker-in-gestational-diabetes
#19
Muhammed Kizilgul, Seyfullah Kan, Selvihan Beysel, Mahmut Apaydin, Ozgur Ozcelik, Mustafa Caliskan, Mustafa Ozbek, Seyda Ozdemir, Erman Cakal
OBJECTIVE: This study was designed to compare the serum levels of fibroblast growth factor 23 (FGF23) among patients with gestational diabetes mellitus (GDM) and healthy pregnant women, and to evaluate the association between hormonal and metabolic parameters. SUBJECTS AND METHODS: A total of 82 pregnant women were consecutively enrolled in the study. Of these, 46 were diagnosed as having GDM; the remaining 36 healthy pregnant women served as controls in a cross-sectional study design...
September 18, 2017: Archives of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28974500/sex-differences-in-circulating-progenitor-cells
#20
Matthew L Topel, Salim S Hayek, Yi-An Ko, Pratik B Sandesara, Ayman Samman Tahhan, Iraj Hesaroieh, Ernestine Mahar, Greg S Martin, Edmund K Waller, Arshed A Quyyumi
BACKGROUND: Lower levels of circulating progenitor cells (PCs) reflect impaired endogenous regenerative capacity and are associated with aging, vascular disease, and poor outcomes. Whether biologic sex and sex hormones influence PC numbers remains a subject of controversy. We sought to determine sex differences in circulating PCs in both healthy persons and patients with coronary artery disease, and to determine their association with sex hormone levels. METHODS AND RESULTS: In 642 participants (mean age 48 years, 69% women, 23% black) free from cardiovascular disease, we measured circulating PC counts as CD45(med+) mononuclear cells coexpressing CD34 and its subsets expressing CD133, chemokine (C-X-C motif) receptor 4, and vascular endothelial growth factor receptor 2 epitopes using flow cytometry...
October 3, 2017: Journal of the American Heart Association
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