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Growth Hormone and aging

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https://www.readbyqxmd.com/read/29222266/impact-of-bone-disease-and-pain-in-thalassemia
#1
REVIEW
Antonio Piga
Conventional treatment of thalassemia, namely regular blood transfusion and iron chelation, improves perspectives and quality of life; however, successful treatment leads to more time in which long-term complications such as bone disease can develop. Thalassemia bone disease (TBD) is unique: all aspects, from bone anatomy and bone quality to mineral density, may be affected, with important morbidity including osteoporosis, fractures, spinal deformities, nerve compression, and pain. Clinical presentations include growth impairment, rickets-like features, back pain, spinal deformities, any sign of nerve compression, severe osteoporosis, and fragility fractures...
December 8, 2017: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/29221939/obesity-and-contraceptive-use-among-women-20-44-years-of-age-in-the-united-states-results-from-the-2011-15-national-survey-of-family-growth-nsfg
#2
William D Mosher, Hannah Lantos, Anne Burke
OBJECTIVE: Obesity has increased dramatically in the US in recent decades. Our objective was to explore associations of contraceptive choices of US women, aged 20-44 years, with body mass index (BMI) and relevant covariates. STUDY DESIGN: Data are based on interviews with a national sample of 11,300 women in the 2011-2015 National Survey of Family Growth (NSFG). We analyzed women ages 20-44 at risk of unintended pregnancy. The primary dependent variable was BMI category...
December 5, 2017: Contraception
https://www.readbyqxmd.com/read/29218462/a-single-institution-experience-with-palbociclib-toxicity-requiring-dose-modifications
#3
Jun Gong, May Cho, Kim Wai Yu, James Waisman, Yuan Yuan, Joanne Mortimer
PURPOSE: Since the widespread implementation of adding palbociclib to endocrine therapy in clinical practice, myelosuppression is becoming increasingly recognized as a toxicity that may lead to dose modification. We aimed to characterize toxicities observed with palbociclib resulting in dose modifications and prescriber preferences in modifying palbociclib dosage in response to treatment-related toxicities outside the context of a clinical trial. METHODS: We conducted a single institution, retrospective study of treatment-related adverse events (AEs) resulting in modifications in dose and schedule and the methods by which dose modifications occurred in patients with advanced hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer receiving palbociclib and endocrine therapy...
December 7, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29217803/growth-hormone-deficiency-in-children-from-suspecting-to-diagnosing
#4
Varuna Vyas, Anil Kumar, Vandana Jain
Isolated Growth hormone deficiency is an important and treatable cause of short stature. However, it is often difficult to diagnose the condition with certainty due to the lack of a single robust diagnostic test. Short children, other than those with the classical phenotype of immature chubby facies, truncal obesity and micropenis in boys, or those with history of cranial lesions with known association with hypopituitarism, should be evaluated for growth hormone deficiency only after excluding the other more common conditions...
November 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29215045/auditory-closed-loop-stimulation-of-eeg-slow-oscillations-strengthens-sleep-and-signs-of-its-immune-supportive-function
#5
Luciana Besedovsky, Hong-Viet V Ngo, Stoyan Dimitrov, Christoph Gassenmaier, Rainer Lehmann, Jan Born
Sleep is essential for health. Slow wave sleep (SWS), the deepest sleep stage hallmarked by electroencephalographic slow oscillations (SOs), appears of particular relevance here. SWS is associated with a unique endocrine milieu comprising minimum cortisol and high aldosterone, growth hormone (GH), and prolactin levels, thereby presumably fostering efficient adaptive immune responses. Yet, whether SWS causes these changes is unclear. Here we enhance SOs in men by auditory closed-loop stimulation, i.e., by delivering tones in synchrony with endogenous SOs...
December 7, 2017: Nature Communications
https://www.readbyqxmd.com/read/29212463/could-a-remarkable-decrease-in-leptin-and-insulin-levels-from-colostrum-to-mature-milk-contribute-to-early-growth-catch-up-of-sga-infants
#6
Marina Nunes, Clécio Homrich da Silva, Vera Lucia Bosa, Juliana Rombaldi Bernardi, Isabel Cristina Ribas Werlang, Marcelo Zubaran Goldani
BACKGROUND: Breast milk is known to contain many bioactive hormones and peptides, which can influence infant growth and development. In this context, the purpose of this study was to evaluate the influence of different clinical pregnancy conditions on hormone concentrations in colostrum and mature breast milk. METHODS: An observational study was performed with mother-newborn pairs divided into five groups according to maternal clinical background: diabetes (12), hypertension (5), smoking (19), intrauterine growth restriction of unknown causes with small-for-gestational-age newborns at delivery (12), and controls (21)...
December 6, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29208686/effects-of-growth-hormone-administration-on-luteinizing-hormone-secretion-in-healthy-older-men-and-women
#7
Ranganath Muniyappa, Shannon D Sullivan, Sri Harsha Tella, Brent S Abel, S Mitchell Harman, Marc R Blackman
The known interactions between the somatotropic and hypothalamic-pituitary-gonadal (HPG) axes have not been well delineated in older individuals. Aging-associated decline in insulin like growth factor-1 (IGF-1) levels has been proposed to play a role in reproductive senescence in animals. However, the effects of GH on LH secretion are unknown in older individuals. Our objective was to determine whether GH modulates LH secretion or levels of sex steroids (SS) in healthy older (ages 65-88 years) men (n = 24) and women (n = 24) with low-normal plasma IGF-1 levels...
December 2017: Physiological Reports
https://www.readbyqxmd.com/read/29200633/effects-of-silver-gymnastic-exercises-on-aging-related-hormones-in-elderly-women-living-alone
#8
Sangsoo Kim, Sungbum Ju
[Purpose] The purpose of this study was to investigate the effect of silver gymnastic exercises on aging-related hormones in elderly women living alone. [Subjects and Methods] The study group consisted of 20 elderly women living alone who performed the silver gymnastic exercises for 12 weeks. Blood samples were obtained for measurement of aging-related hormones (human growth hormone [HGH] and estrogen). [Results] HGH and estrogen levels increased significantly after the exercise program as compared to before the program...
November 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/29197861/short-term-adverse-effects-of-testosterone-used-for-priming-in-prepubertal-boys-before-growth-hormone-stimulation-test
#9
Andrea Albrecht, Theresa Penger, Michaela Marx, Karin Hirsch, Helmuth G Dörr
BACKGROUND: Despite the fact that priming with sex steroids in prepubertal children before growth hormone (GH) provocative tests is recommended, there is an ongoing controversial discussion about the appropriate age of the children, the drug used for priming, the dose and the period between priming and the GH test. Interestingly, there is no discussion on the safety of this procedure. To date, only little data have been available on the possible side effects of priming with testosterone...
December 4, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29197219/growth-response-to-growth-hormone-treatment-in-patients-with-shox-deficiency-can-be-predicted-by-the-cologne-prediction-model
#10
Heike Hoyer-Kuhn, Jeremy Franklin, Christine Jones, Werner F Blum, Eckhard Schoenau
Background Growth hormone (GH) treatment in children with short stature homeobox-containing gene (SHOX) deficiency is recognized to increase height velocity (HV) and adult height. Prediction of growth response continues to be a challenge. A comparatively accurate method is the Cologne prediction model developed in children with GH deficiency. The aim was to investigate whether this model also applies to patients with SHOX deficiency. Methods Included were 48 patients with SHOX deficiency confirmed by DNA analysis and treated with 0...
December 2, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29192304/association-of-hearing-loss-and-otologic-outcomes-with-fibrous-dysplasia
#11
Alison M Boyce, Carmen Brewer, Timothy R DeKlotz, Christopher K Zalewski, Kelly A King, Michael T Collins, H Jeffrey Kim
Importance: Fibrous dysplasia (FD) and McCune-Albright syndrome (MAS) are rare bone and endocrine disorders in which expansile fibro-osseous lesions result in deformity, pain, and functional impairment. The effect of FD on hearing and otologic function has not been established. Objectives: To characterize audiologic and otologic manifestations in a large cohort of individuals with FD/MAS and to investigate potential mechanisms of hearing loss. Design, Setting, and Participants: In this natural history study, individuals with craniofacial FD seen at a clinical research center underwent clinical, biochemical, computed tomographic, audiologic, and otolaryngologic evaluations...
November 30, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/29191181/immunohistochemistry-defined-subtypes-of-breast-cancer-in-678-sudanese-and-eritrean-women-hospitals-based-case-series
#12
Asmerom Tesfamariam Sengal, Nada Suliman Haj-Mukhtar, Ahmed Mohammed Elhaj, Shahinaz Bedri, Eva Johanna Kantelhardt, Ahmed A Mohamedani
BACKGROUND: Breast cancer is the most common malignancy accounting for 25% of all cancers in females. In Africa, breast cancer prevalence and mortality are steadily increasing. Knowledge of hormone receptors and human epidermal growth factor receptor-2 (HER-2) expressions are vital for breast cancer management plans and decision making. There is wide regional variation in the proportion of these biomarkers, especially in African countries. Hormone receptors positivity in indigenous African and African American women is considered to be low and triple negative breast cancer is a dominant phenotype...
December 1, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29189197/hr-pqct-detects-alterations-in-bone-microstructure-in-men-with-ckd-stages-3-and-4-which-are-influenced-by-hormonal-changes-and-body-composition%C3%A2
#13
Francisco P Paranhos-Neto, Guilherme A C Lima, Luciana C Silva, Miguel Madeira, Leonardo Vieira Neto, Laura M C Mendonça, Inayá C B Lima, Alvimar G Delgado, Maurilo Leite, Carlos P Gomes, Maria Lucia F Farias
INTRODUCTION: Factors associated with osteodystrophy in predialysis patients are poorly understood. In the present study, we attempted to evaluate the impact of body composition and hormonal regulatory factors on the bone microstructure in a group of men with chronic kidney disease (CKD) stages 3 and 4. MATERIALS AND METHODS: 46 men, aged 50 - 75 years, with previously unrecognized CKD were evaluated by high-resolution peripheral quantitative computed tomography (HR-pQCT), and dual-energy X-ray absorptiometry (DXA)...
November 30, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/29186712/reproductive-hormones-and-their-receptors-may-affect-lung-cancer
#14
Mengmeng Dou, Keyan Zhu, Zhirui Fan, Yuxuan Zhang, Xiufang Chen, Xueliang Zhou, Xianfei Ding, Lifeng Li, Zhaosen Gu, Maofeng Guo, Ming Yan, Xiaoming Deng, Peihong Shen, Shuling Wang
BACKGROUND/AIMS: In contrast to men, women have experienced a rapid increase in lung cancer mortality. Numerous studies have found that the sex differences in lung cancer are due to reproductive hormones. Experiments in female mice with and without ovariectomy were performed to explore the possible mechanism by which sex hormones (and their receptors) influence lung cancer. METHODS: Twenty-four female C57BL/6 mice aged 56-62 days were randomly divided into the ovariectomized group and the control group...
November 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29186429/extracellular-matrix-in-uterine-leiomyoma-pathogenesis-a-potential-target-for-future-therapeutics
#15
Md Soriful Islam, Andrea Ciavattini, Felice Petraglia, Mario Castellucci, Pasquapina Ciarmela
BACKGROUND: Uterine leiomyoma (also known as fibroid or myoma) is the most common benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can produce serious clinical symptoms, including excessive uterine bleeding, pelvic pain or pressure, infertility and pregnancy complications. Due to lack of effective medical treatments surgery has been a definitive choice for the management of this tumor. OBJECTIVE AND RATIONALE: Extracellular matrix (ECM) accumulation and remodeling are thought to be crucial for fibrotic diseases such as uterine leiomyoma...
November 23, 2017: Human Reproduction Update
https://www.readbyqxmd.com/read/29185202/tumor-infiltrating-lymphocytes-affect-the-efficacy-of-trastuzumab-based-treatment-in-human-epidermal-growth-factor-receptor-2-positive-breast-cancer
#16
Hiroaki Inoue, Rie Horii, Yoshinori Ito, Takuji Iwase, Shinji Ohno, Futoshi Akiyama
BACKGROUND: Immune responses play an important role in interrupting the progression of cancer cells. Tumor-infiltrating lymphocytes (TILs) are basic components of the immune system. In triple negative breast cancer, increased number of TILs is associated with excellent prognosis and response of chemotherapy. Here, we investigated whether TILs affect the efficacy of trastuzumab-based treatment in human epidermal growth factor receptor 2 (HER2)-positive breast cancer. METHODS: The study included 97 patients with stage I-III HER2-positive breast cancer...
November 28, 2017: Breast Cancer: the Journal of the Japanese Breast Cancer Society
https://www.readbyqxmd.com/read/29184538/circulating-irisin-is-reduced-in-male-patients-with-type-1-and-type-2-myotonic-dystrophies
#17
Elena Dozio, Elena Passeri, Rosanna Cardani, Stefano Benedini, Carmen Aresta, Rea Valaperta, Massimiliano Corsi Romanelli, Giovanni Meola, Valeria Sansone, Sabrina Corbetta
Context: Myotonic dystrophies (DM) are dominantly inherited muscle disorders characterized by myotonia, muscle weakness, and wasting. The reasons for sarcopenia in DMs are uncleared and multiple factors are involved. Irisin, a positive hormone regulator of muscle growth and bone, may play a role. Objectives: To investigate (1) circulating irisin in a series of DM1 and DM2 male patients compared with healthy controls and (2) the relationships between irisin and anthropometric, metabolic and hormonal parameters...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29184085/diverse-changes-of-circulating-fibroblast-growth-factor-21-levels-in-hepatitis-b-virus-related-diseases
#18
Liang Wu, Qingchun Pan, Guangyu Wu, Lingling Qian, Jing Zhang, Lei Zhang, Qichen Fang, Guoqing Zang, Yudong Wang, George Lau, Huating Li, Weiping Jia
Fibroblast growth factor 21 (FGF21), a stress-induced hormone in the liver, has been shown the protective functions in pathological conditions. The study investigated the association of circulating FGF21 with hepatitis B virus (HBV) infection and its related diseases. Serum FGF21 levels were measured in 33 acute hepatitis B (AHB), 75 chronic hepatitis B (CHB) and 66 CHB patients with advanced liver diseases including liver cirrhosis, acute-on-chronic liver failure (ALCF) and hepatocellular carcinoma (HCC) together with 200 age- and BMI-matched healthy controls...
November 28, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29175735/prognostic-impact-of-interval-breast-cancer-detection-in-women-with-pt1a-n0m0-breast-cancer-with-her2-positive-status-results-from-a-multicentre-population-based-cancer-registry-study
#19
A Musolino, F Falcini, A Sikokis, D Boggiani, A Rimanti, B Pellegrino, E M Silini, N Campanini, E Barbieri, C Zamagni, R Degli Esposti, L Cortesi, G Bisagni, L Cavanna, A Frassoldati, P Sgargi, M Michiara
BACKGROUND: Although human epidermal growth factor receptor 2 (HER2) overexpression is associated with poor prognosis, patients (pts) with pT1a N0M0 breast cancers (BCs) have an excellent outcome across all subtypes. Interval cancers (ICs) have poorer survival than screen-detected (SD) tumours, and an association has been reported between ICs and HER2 overexpression. We aimed to determine, in a general population of pT1a N0M0 BCs with known screening status, whether HER2-positive ICs have a poorer outcome than HER2-positive SD cancers...
November 23, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29175324/lixisenatide-reduces-amyloid-plaques-neurofibrillary-tangles-and-neuroinflammation-in-an-app-ps1-tau-mouse-model-of-alzheimer-s-disease
#20
Hong-Yan Cai, Jun-Ting Yang, Zhao-Jun Wang, Jun Zhang, Wei Yang, Mei-Na Wu, Jin-Shun Qi
Type 2 diabetes mellitus (T2DM) has been identified as a high risk factor for Alzheimer's disease (AD). The impairment of insulin signaling has been found in AD brain. Glucagon-like peptide-1 (GLP-1) is an incretin hormone, normalises insulin signaling and acts as a neuroprotective growth factor. We have previously shown that the long-lasting GLP-1 receptor (GLP-1R) agonist lixisenatide plays an important role in memory formation, synaptic plasticity and cell proliferation of rats. In the follow-up study, we analysed the neuroprotective effect and mechanism of lixisenatide, injected for 60 days at 10 nmol/kg i...
November 21, 2017: Biochemical and Biophysical Research Communications
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