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https://www.readbyqxmd.com/read/29156782/trends-in-neoadjuvant-chemotherapy-use-and-oncological-outcomes-for-muscle-invasive-bladder-cancer-in-japan-a-multicenter-study
#1
Go Anan, Shingo Hatakeyama, Naoki Fujita, Hiromichi Iwamura, Toshikazu Tanaka, Hayato Yamamoto, Yuki Tobisawa, Tohru Yoneyama, Takahiro Yoneyama, Yasuhiro Hashimoto, Takuya Koie, Hiroyuki Ito, Kazuaki Yoshikawa, Toshiaki Kawaguchi, Makoto Sato, Chikara Ohyama
Objective: Despite benefits of neoadjuvant chemotherapy (NAC), the adoption of guideline recommendations for NAC use in patients with muscle-invasive bladder cancer (MIBC) has been slow. We aimed to evaluate temporal trends in NAC use and oncological outcomes in a representative cohort of patients with MIBC. Methods: We included 532 patients from 4 hospitals who underwent radical cystectomy (RC) for ≥ cT2 MIBC in 1996-2017. We retrospectively evaluated temporal changes in NAC use and progression-free and overall survival...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29155338/financial-toxicity-in-bladder-cancer-patients-reasons-for-delay-in-care-and-effect-on-quality-of-life
#2
Marianne M Casilla-Lennon, Seul Ki Choi, Allison M Deal, Jeannette T Bensen, Gopal Narang, Pauline Filippou, Benjamin McCormick, Raj Pruthi, Eric Wallen, Hung-Jui Tan, Michael Woods, Matthew Nielsen, Angela Smith
PURPOSE: Costly surveillance and treatment of bladder cancer can lead to financial toxicity (FT), a treatment-related financial burden. Our objective was to define the prevalence of FT among bladder cancer patients and identify delays in care and its effect on health-related quality of life (HRQOL). METHODS: We identified bladder cancer patients in the UNC Health Registry/Cancer Survivorship Cohort. FT was defined as agreement with having "to pay more for medical care than you can afford...
November 16, 2017: Journal of Urology
https://www.readbyqxmd.com/read/29154513/propensity-score-matched-comparison-between-complete-mesocolic-excision-and-classic-right-hemicolectomy-for-colon-cancer-an-italian-and-egyptian-experience
#3
Eva Lieto, Mohamed Abdelkhalek, Michele Orditura, Adel Denewer, Paolo Castellano, Tamer F Youssef, Annamaria Auricchio, Ahmed Setit, Gennaro Galizia
BACKGROUND: The prognosis of right colon cancer remains disappointing. Complete mesocolic excision (CME) with central vascular ligation (CVL), based on the same oncological principles of total mesorectal excision, has been speculated to result in a better outcome. To evaluate the oncological adequacy of CME with CVL, we carried out a comparative study with propensity score-matched analysis between two different surgical procedures performed at Italian and Egyptian University cancer centers...
November 20, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29154512/laparoscopic-vs-open-approach-for-pt3-pt4-colorectal-cancer-in-the-elderly-ten-year-experience-in-a-single-center
#4
Marina Troian, Gabriele Bellio, Arianna Pasquali, Nicolò DE Manzini
BACKGROUND: The role of laparoscopic surgery for pT3/pT4 colorectal cancer (CRC) is still under debate. The aim of this study was to compare the outcomes of laparoscopic and open procedures for pT3/pT4 CRC in elderly patients. METHODS: From January 2004 to December 2015, 225 patients aged ≥ 70 years underwent elective colorectal surgery for pT3/pT4 CRC at the Department of General Surgery, University Hospital of Trieste. Patients' demographics, tumor's characteristics, intraoperative factors, short- term and long-term outcomes were retrospectively analyzed...
November 20, 2017: Minerva Chirurgica
https://www.readbyqxmd.com/read/29154173/prognostic-value-of-tumour-infiltrating-lymphocytes-in-small-her2-positive-breast-cancer
#5
Carmen Criscitiello, Vincenzo Bagnardi, Giancarlo Pruneri, Andrea Vingiani, Angela Esposito, Nicole Rotmensz, Giuseppe Curigliano
BACKGROUND: The standard treatment for patients with small, node-negative, human epidermal growth factor receptor type 2 (HER2)-positive breast cancer (BC) is still controversial. Our aim was to assess the prognostic role of tumour-infiltrating lymphocytes (TILs) in patients with stage pT1a-b HER2-positive BC. PATIENTS AND METHODS: Haematoxylin and eosin slides from node-negative, pT1a-b HER2-positive BC surgical specimens were retrieved from pathology archives to assess TILs and their association with outcome...
November 15, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/29154042/oncological-outcomes-of-laparoscopic-nephroureterectomy-versus-open-radical-nephroureterectomy-for-upper-tract-urothelial-carcinoma-an-european-association-of-urology-guidelines-systematic-review
#6
REVIEW
Benoit Peyronnet, Thomas Seisen, Jose-Luis Dominguez-Escrig, Harman Max Bruins, Cathy Yuhong Yuan, Thomas Lam, Steven Maclennan, James N'dow, Marko Babjuk, Eva Comperat, Richard Zigeuner, Richard J Sylvester, Maximilian Burger, Hugh Mostafid, Bas W G van Rhijn, Paolo Gontero, Joan Palou, Sharokh F Shariat, Morgan Roupret
CONTEXT: Most series have suggested better perioperative outcomes of laparoscopic radical nephroureterectomy (RNU) over open RNU. However, the oncological safety of laparoscopic RNU remains controversial. OBJECTIVE: To systematically review all relevant literature comparing oncological outcomes of open versus laparoscopic RNU. EVIDENCE ACQUISITION: A systematic literature search using the Medline, Embase, and Cochrane databases and clinicaltrial...
November 15, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29153885/are-the-results-of-the-prostate-testing-for-cancer-and-treatment-trial-applicable-to-contemporary-prostate-cancer-patients-treated-with-radical-prostatectomy-results-from-two-high-volume-european-institutions
#7
Giorgio Gandaglia, Derya Tilki, Emanuele Zaffuto, Nicola Fossati, Raisa S Pompe, Paolo Dell'Oglio, Markus Graefen, Francesco Montorsi, Alberto Briganti
The Prostate Testing for Cancer and Treatment (ProtecT) trial reported excellent outcomes for patients with localized prostate cancer (PCa) managed with radical prostatectomy (RP), radiotherapy, or active monitoring. We aimed at assessing the generalizability of the ProtecT trial to contemporary patients undergoing RP at two high-volume institutions. Overall, 29147 PCa patients treated with RP between 1999 and 2016 were included. We evaluated changes in disease characteristics over time. Competing-risk analyses estimated the 10-yr cancer-specific mortality (CSM) and other-cause mortality (OCM) rates...
November 16, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29152598/study-protocol-a-randomized-controlled-trial-of-a-comprehensive-breast-cancer-treatment-patient-decision-tool-icandecide
#8
Sarah T Hawley, Yun Li, L Alexandra Jeanpierre, Stefanie Goodell, Reshma Jagsi, Kevin C Ward, Michael S Sabel, Steven J Katz
Background: Patients newly diagnosed with breast cancer face a series of complex decisions regarding locoregional and systemic treatment. There is a need to improve the quality of locoregional and systemic decisions for breast cancer patients, and to help patients understand the role of evaluative tests in this decision process. We are now conducting a randomized controlled trial (RCT) of an online decision tool-called iCanDecide, which we expect will help patients with these difficult decisions...
March 2017: Contemporary Clinical Trials Communications
https://www.readbyqxmd.com/read/29152553/oncological-outcomes-of-sequential-intravesical-gemcitabine-and-docetaxel-in-patients-with-non-muscle-invasive-bladder-cancer
#9
Niv Milbar, Max Kates, Meera R Chappidi, Filippo Pederzoli, Takahiro Yoshida, Alexander Sankin, Phillip M Pierorazio, Mark P Schoenberg, Trinity J Bivalacqua
Background: Bacillus Calmette-Guérin (BCG) unresponsive/relapsing patients with non-muscle invasive bladder cancer (NMIBC) who prefer bladder preservation over radical cystectomy (RC) or those who do not qualify for surgery may be offered intravesical therapies. Gemcitabine (GEM) combined with Docetaxel (DOCE) has been offered at Johns Hopkins Hospital (JHH). Objective: To evaluate experience with GEM/DOCE, to confirm safety of the regimen, to identify populations that may benefit most, and to consider the appropriate endpoints for judging efficacy of second line therapies...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29152547/evidence-of-atypical-recurrences-after-robot-assisted-radical-cystectomy-a-comprehensive-review-of-the-literature
#10
REVIEW
François Audenet, John P Sfakianos
Robot-assisted radical cystectomy (RARC) has seen remarkable growth in the last decade. Despite a low level of evidence, numerous publications reporting on outcomes after RARC are now available. While definitive data on the long-term oncologic safety and efficacy of this technique are still lacking, similar oncological and functional outcomes compared to open radical cystectomy (ORC) have been reported. Several studies have also reported on atypical recurrences after RARC, including peritoneal carcinomatosis, extra-pelvic lymph node metastasis and port-site metastasis...
October 27, 2017: Bladder Cancer
https://www.readbyqxmd.com/read/29151942/gender-related-outcome-in-bladder-cancer-patients-undergoing-radical-cystectomy
#11
Renate Pichler, Josef Fritz, Isabel Heidegger, Wilhelm Oberaigner, Wolfgang Horninger, Margarethe Hochleitner
Background: The impact of gender on oncological outcome after radical cystectomy (RC) is not fully understood yet. The aim of the study was to evaluate gender-related differences in histopathological parameters and prognosis of patients with bladder cancer undergoing RC. Methods: A retrospective analysis of a 10-year single-center cystectomy database was performed. Kaplan-Meier survival and Cox-regression analyses with sex-specific interactions were performed to determine the impact of gender on recurrence-free survival (RFS), cancer-specific survival (CSS), and overall survival (OS), in addition to established clinicopathological factors...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/29150906/pretreatment-advanced-lung-cancer-inflammation-index-ali-for-predicting-early-progression-in-nivolumab-treated-patients-with-advanced-non-small-cell-lung-cancer
#12
Takayuki Shiroyama, Hidekazu Suzuki, Motohiro Tamiya, Akihiro Tamiya, Ayako Tanaka, Norio Okamoto, Kenji Nakahama, Yoshihiko Taniguchi, Shun-Ichi Isa, Takako Inoue, Fumio Imamura, Shinji Atagi, Tomonori Hirashima
Programmed death-ligand 1 (PD-L1) expression status is inadequate for indicating nivolumab in patients with non-small cell lung cancer (NSCLC). Because the baseline advanced lung cancer inflammation index (ALI) is reportedly associated with patient outcomes, we investigated whether the pretreatment ALI is prognostic in NSCLC patients treated with nivolumab. We retrospectively reviewed the medical records of all patients treated with nivolumab for advanced NSCLC between December 2015 and May 2016 at three Japanese institutes...
November 18, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29150094/-geriatric-assessment-and-prognostic-scores-in-older-cancer-patient-additional-support-to-the-therapeutic-decision
#13
REVIEW
Frédéric Pamoukdjian, Evelyne Liuu, Philippe Caillet, Mathilde Gisselbrecht, Stéphane Herbaud, Pascaline Boudou-Rouquette, Laurent Zelek, Elena Paillaud
Cancer is a disease of the elderly as demonstrated by the epidemiological evolution of Western countries. Indeed, two third of cancers newly diagnosed occur over 65 years. However, older cancer patients have been often excluded from clinical trials in oncology and the extrapolation of cancer treatments in this population remains difficult in practice. Scientific societies recommend that a comprehensive geriatric assessment (CGA) be performed in patients aged 70 and over and selected using screening tools for frailty such as the G8 index...
November 14, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29149493/impact-of-chronic-hepatitis-c-virus-infection-on-the-survival-of-patients-with-oropharyngeal-cancer
#14
Minas P Economides, Moran Amit, Parag S Mahale, Jeff J Hosry, Ying Jiang, Uddalak Bharadwaj, Erich M Sturgis, Harrys A Torres
BACKGROUND: Although an association between hepatitis C virus (HCV) infection and oropharyngeal cancers (OPCs) has been reported, to the authors' knowledge the clinical significance of this epidemiological finding remains unknown. Therefore, the authors analyzed the oncologic outcomes of HCV-infected patients with OPCs. METHODS: In this retrospective cohort study, all patients with OPCs who were seen at The University of Texas MD Anderson Cancer Center between January 2004 and December 2015 were reviewed...
November 17, 2017: Cancer
https://www.readbyqxmd.com/read/29149427/the-impact-of-the-national-bowel-screening-program-in-the-netherlands-on-detection-and-treatment-of-endoscopically-unresectable-benign-polyps
#15
C C M Marres, C J Buskens, E Schriever, P C M Verbeek, M W Mundt, W A Bemelman, A W H van de Ven
BACKGROUND: In January 2014, a national bowel cancer screening program started in the Netherlands. The program is being implemented in phases until 2019. Due to this program, an increase in patients referred for a colorectal resection for benign, but endoscopically unresectable polyps, is expected. So far, most resections are performed according to oncological principles despite no pre-operative histological diagnosis of malignancy. The aim of this study was to analyze the increase in referred patients during the first year of the screening program and to compare pathological results and clinical outcome of resections of patients undergoing resection for benign polyps before and after implementation of screening...
November 17, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29149130/errors-in-genetic-testing-common-causes-and-strategies-for-prevention
#16
Suzanne M Mahon
Genetic testing for hereditary cancer syndromes is an integral component of oncology care. Various types of common errors that occur in the genetic testing process are presented in this article with actual clinical case examples and commentary. Genetic errors are expensive and may result in poor outcomes for the patient and his or her family. Oncology nurses need to be aware of potential sources of error and advocate for comprehensive genetic care.
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December 1, 2017: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29148638/factors-associated-with-treatment-outcome-of-pediatric-cancerpatients-admitted-with-febrile-neutropenia-in-tikuranbessa-specialized-teaching-hospital-addis-ababa-ethiopia
#17
Selamawit Assefa, Tinsae Alemayehu, Workeabeba Abebe
Background: Cancer treatment is associated with variable degrees of myelosupression. Infection is often a life-threatening complication of chemotherapy-induced neutropenia, and it is also considered an oncologic emergency. Febrile neutropenia is a common, costly and potentially fatal complication in oncology. Objective: To assess factors affecting treatment outcome of cancer patients with chemotherapy induced febrile neutropenia. Method: We conducted a review of records of pediatric patients hospitalized and treated for chemotherapy-induced febrile neutropenia from January 1, 2013 to December 31, 2013 and met the selection criteria...
January 2017: Ethiopian Medical Journal
https://www.readbyqxmd.com/read/29147759/patterns-and-predictors-of-recurrence-after-open-radical-cystectomy-for-bladder-cancer-a-comprehensive-review-of-the-literature
#18
REVIEW
Andrea Mari, Riccardo Campi, Riccardo Tellini, Giorgio Gandaglia, Simone Albisinni, Mohammad Abufaraj, Georgios Hatzichristodoulou, Francesco Montorsi, Roland van Velthoven, Marco Carini, Andrea Minervini, Shahrokh F Shariat
PURPOSE: To review the currently available literature reporting the patterns of recurrence and their predictive factors after open radical cystectomy (RC) for bladder cancer. METHODS: A review of the literature was performed using the MEDLINE, Scopus and Web of Sciences databases from January 1997 to May 2017. The PRISMA guidelines were followed for the conduct of the study. RESULTS: Local recurrence rate ranges between 30 and 54%. Distant recurrence is not often standardized and is reported in up to 50% of cases...
November 16, 2017: World Journal of Urology
https://www.readbyqxmd.com/read/29147444/visceral-crisis-means-short-survival-among-patients-with-luminal-a-metastatic-breast-cancer-a-retrospective-cohort-study
#19
Yassir Sbitti, Khaoula Slimani, Adil Debbagh, Anouar Mokhlis, Habiba Kadiri, Abdelilah Laraqui, Hassan Errihani, Mohamed Ichou
Background: Patients with visceral crisis from luminal metastatic breast cancer (mBC) are often treated with palliative chemotherapy. No studies have analyzed the aggressiveness of the care in visceral crisis from luminal mBC patients. The objective of this study was to assess practices in this setting in a university medical oncology department. Methods: This retrospective study included all patients who were managed for luminal mBC between January 2013 and April 2016...
August 2017: World Journal of Oncology
https://www.readbyqxmd.com/read/29147004/dose-de-escalation-to-the-normal-larynx-using-conformal-radiotherapy-reduces-toxicity-while-maintaining-oncologic-outcome-for-t1-t2-glottic-cancer
#20
Jun Won Kim, Hyung Kwon Byeon, Hong-Shik Choi, Ik Jae Lee
We evaluated the efficacy of dose de-escalation to the normal larynx using conformal radiotherapy (CRT) for T1/T2 glottic cancer. For conventional RT (2DRT, n = 38), the laryngeal box received a median equivalent dose in 2 Gy fractions (EQD2) of 66 Gy. For CRT (n = 42; 3D-CRT, 20; intensity-modulated RT, 22), clinical target volume (CTV)1 (gross tumor with a 3-mm margin) and CTV2 (laryngeal box) received median EQD2s of 66.6 Gy and 52.2 Gy, respectively. With a 71-month median follow-up, five-year local control and overall survival rates for 2DRT vs...
November 16, 2017: Scientific Reports
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