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Testosterone and aging

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https://www.readbyqxmd.com/read/28731686/pyrethroid-insecticide-cypermethrin-accelerates-pubertal-onset-in-male-mice-via-disrupting-hypothalamic-pituitary-gonadal-axis
#1
Xiaoqing Ye, Feixue Li, Jianyun Zhang, Huihui Ma, Dapeng Ji, Xin Huang, Thomas E Curry, Weiping Liu, Jing Liu
Pyrethroids, a class of insecticides that are widely used worldwide, have been identified as endocrine-disrupting chemicals (EDCs). Our recent epidemiological study reported on an association of increased pyrethroids exposure with elevated gonadotropins levels and earlier pubertal development in Chinese boys. In this study, we further investigated the effects of cypermethrin (CP), one of the most ubiquitous pyrethroid insecticides, on hypothalamic-pituitary-gonadal (HPG) axis and pubertal onset in male animal models...
July 21, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28729707/status-stress-and-performance-in-track-and-field-athletes-during-the-european-games-in-baku-azerbaijan
#2
Benjamin Siart, Alfred Nimmerichter, Claudia Vidotto, Bernard Wallner
This study analyzes the relationship between salivary cortisol and testosterone levels and performance in track and field athletes. In addition, we analyzed the influence of status among athletes (measured based on previous athletic achievement) on hormone levels. Nineteen members of the Austrian track and field team (eleven males, eight females, 25.9 ± 3.9 years of age, 74.9 ± 20.1 kg, and 179.3 ± 10 cm) participated in this study. Data was collected during the European Games in Baku. Athletes delivered saliva samples at various time-points including morning samples and samples directly before and after the competition...
July 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28728990/long-term-testosterone-therapy-improves-urinary-and-sexual-function-and-quality-of-life-in-men-with-hypogonadism-results-from-a-propensity-matched-subgroup-of-a-controlled-registry-study
#3
Karim Sultan Haider, Ahmad Haider, Gheorghe Doros, Abdulmaged Traish
OBJECTIVES: To investigate the effects of long-term testosterone (T) therapy (TTh) on urinary and sexual functions and quality of life (QoL) in hypogonadal men. PATIENTS AND METHODS: Observational, prospective, cumulative registry study in 656 men (age: 60.7 ± 7.2 years) with total T levels ≤12.1 nmol/L and symptoms of hypogonadism. In the T-treated group, men (n = 360) received parenteral T undecanoate (TU) 1000 mg/12 weeks for up to 10 years. Men who opted against TTh (n= 296) served as controls...
July 17, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28728135/prostate-cancer-risk-and-dna-methylation-signatures-in-aging-rats-following-developmental-bpa-exposure-a-dose-response-analysis
#4
Gail S Prins, Shu-Hua Ye, Lynn Birch, Xiang Zhang, Ana Cheong, Han Lin, Esther Calderon-Gierszal, Jacob Groen, Wen-Yang Hu, Shuk-Mei Ho, Richard B van Breemen
BACKGROUND: Previous studies have uncovered heightened prostatic susceptibility to hormone-induced neoplasia from early-life exposure to low-dose bisphenol A (BPA). However, significant data gaps remain that are essential to address for biological relevance and necessary risk assessment. OBJECTIVES: A complete BPA dose-response analysis of prostate lesions across multiple prostatic lobes was conducted that included internal BPA dosimetry, progression to adenocarcinoma with aging and mechanistic connections to epigenetically reprogramed genes...
July 11, 2017: Environmental Health Perspectives
https://www.readbyqxmd.com/read/28727906/potential-of-telmisartan-in-the-treatment-of-benign-prostatic-hyperplasia
#5
Ismail Ogunbayode Ishola, Charles C Anunobi, Kehinde Habeeb Tijani, Olasunmbo Afolayan, Victoria U Udokwu
Benign prostatic hyperplasia (BPH) is a common health problem in aging men. This study was carried out to investigate the protective effect of telmisartan on testosterone induced-BPH in rats. Fifty-four male Wistar rats (200 - 250g) were randomly divided into 9 groups (n =6) and orally treated for 28 consecutive days: group 1- vehicle normal, olive oil (10 ml/kg); group 2- BPH model control (10 ml/kg); groups 3-5 - telmisartan (5, 10 or 20 mg/kg, respectively); group 6- pioglitazone (20 mg/kg); group 7- celecoxib (20 mg/kg); group 8- combination of telmisartan (5 mg/kg) and pioglitazone (20 mg/kg); group 9- combination of telmisartan (5 mg/kg) and celecoxib (20 mg/kg)...
July 20, 2017: Fundamental & Clinical Pharmacology
https://www.readbyqxmd.com/read/28724741/body-height-and-immune-efficacy-testing-body-stature-as-a-signal-of-biological-quality
#6
Bogusław Pawłowski, Judyta Nowak, Barbara Borkowska, Daria Augustyniak, Zuzanna Drulis-Kawa
According to the good genes hypothesis and energy allocation theory, human adult body height may reflect biological quality. An important aspect of this quality is immune system functioning (ISF). The aim of this study was to evaluate the relationship between ISF and body height in healthy people. The ISF was determined by several important innate (total complement and lysozyme activity, neutrophil function) and adaptive immune parameters (lymphocytes, IgA and IgG, and response to the flu vaccine). Overall, 96 males and 97 females were subjected to flu vaccination, and of these, 35 males and 34 females were subjected to tetanus...
July 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28723965/the-prevalence-and-metabolic-characteristics-of-polycystic-ovary-syndrome-in-the-qatari-population
#7
Soha R Dargham, Lina Ahmed, Eric S Kilpatrick, Stephen L Atkin
OBJECTIVE: The prevalence of polycystic ovary syndrome (PCOS) in the Qatari population is unknown and hence the estimated impact on the local population cannot be determined. The purpose of this study was to estimate the prevalence and metabolic features of PCOS among Qatari women. DESIGN: Cross sectional analysis. PATIENTS: 3,017 Qatari subjects volunteered to be phenotyped and genotyped for the Qatar Biobank from which all women between the ages of 18-40 years were identified (750)...
2017: PloS One
https://www.readbyqxmd.com/read/28723963/impact-of-thyroid-function-abnormalities-on-reproductive-hormones-during-menstrual-cycle-in-premenopausal-hiv-infected-females-at-nauth-nnewi-nigeria
#8
Nkiruka Rose Ukibe, Solomon Nwabueze Ukibe, Obiageli Fidelia Emelumadu, Chinedum Charles Onyenekwe, Joseph Eberendu Ahaneku, Anthony Osita Igwegbe, Ifeoma Nwamaka Monago, Amobi Linus Ilika
BACKGROUND: This was a prospective study designed to evaluate the impact of thyroid function abnormalities on reproductive hormones during menstrual cycle in HIV infected females at Nnamdi Azikiwe University Teaching Hospital Nnewi, South-East Nigeria. METHODS: The study randomly recruited 35 Symptomatic HIV infected females and 35 Symptomatic HIV infected females on antiretroviral therapy (HAART) for not less than six weeks from an HIV clinic and 40 apparently heathy control females among the hospital staff of NAUTH Nnewi...
2017: PloS One
https://www.readbyqxmd.com/read/28723610/pediatric-reference-intervals-for-29-ortho-vitros-5600-immunoassays-using-the-caliper-cohort-of-healthy-children-and-adolescents
#9
Victoria Higgins, Angela W S Fung, Man Khun Chan, Joseph Macri, Khosrow Adeli
BACKGROUND: Accurate reference intervals (RIs) based on a healthy pediatric population are essential for pediatric test result interpretation. The CALIPER project has recruited a large healthy cohort and completed a series of a priori studies to address gaps in pediatric RIs. As immunoassays from different manufacturers for endocrine and special chemistry markers are not standardized and show marked intermethod differences, direct RI studies are needed for each major analytical platform...
July 19, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28721134/osteoporosis-in-men
#10
REVIEW
Waldemar Misiorowski
Osteoporotic fractures are the leading cause of morbidity and mortality among aging men. 30% of all hip fractures occur in men, and mortality resulting from not only the hip fracture, but also the spine and other major osteoporotic fractures, is significantly higher in men than in women. As in women, hypogonadism is the best documented risk factor for developing osteoporosis in men. In older men, testosterone levels are negatively correlated with the risk of fractures, and it seems that this age-related testosterone deficiency should not be considered as one of the many causes of secondary osteoporosis, rather one of the major and most important mechanisms of senile osteoporosis...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28721133/late-onset-hypogonadism
#11
REVIEW
Piotr Dudek, Jarosław Kozakowski, Wojciech Zgliczyński
In Poland, the number of men over the age of 50 years exceeds 6 million. It is estimated that about 2-6% of this population develops symptoms of late-onset hypogonadism (LOH). In men, testosterone deficiency increases slightly with age. LOH is a clinically and biochemically defined disease of older men with serum testosterone level below the reference parameters of younger healthy men and with symptoms of testosterone deficiency, manifested by pronounced disturbances of quality of life and harmful effects on multiple organ systems...
June 2017: Przeglad Menopauzalny, Menopause Review
https://www.readbyqxmd.com/read/28720108/early-pregnancy-sex-steroids-during-primiparous-pregnancies-and-maternal-breast-cancer-a-nested-case-control-study-in-the-northern-sweden-maternity-cohort
#12
Renée T Fortner, Eglé Tolockiene, Helena Schock, Husam Oda, Hans-Åke Lakso, Göran Hallmans, Rudolf Kaaks, Paolo Toniolo, Anne Zeleniuch-Jacquotte, Kjell Grankvist, Eva Lundin
BACKGROUND: Pregnancy and parity are associated with subsequent breast cancer risk. Experimental and epidemiologic data suggest a role for pregnancy sex steroid hormones. METHODS: We conducted a nested case-control study in the Northern Sweden Maternity Cohort (1975-2007). Eligible women had provided a blood sample in the first 20 weeks of gestation during a primiparous pregnancy leading to a term delivery. The current study includes 223 cases and 417 matched controls (matching factors: age at and date of blood collection)...
July 18, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/28719047/effect-of-typha-capensis-rohrb-n-e-br-rhizome-extract-f1-fraction-on-cell-viability-apoptosis-induction-and-testosterone-production-in-tm3-leydig-cells
#13
A Ilfergane, R R Henkel
Typha capensis (Rohrb.)N.E.Br. (bulrush) is used by traditional healers in Southern Africa to treat male reproductive problems. This study aimed at investigating the effects of T. capensis on TM3-Leydig cells. T. capensis rhizome crude extract obtained from autumn, winter, spring and summer harvest was fractionated using HPLC into four fractions, and TM3-Leydig cells were incubated with different concentrations of the F1 fraction (0.01, 0.02, 0.1, 1, 10 and 100 μg/ml) for 24, 48 and 96 hr respectively...
July 18, 2017: Andrologia
https://www.readbyqxmd.com/read/28717276/testosterone-versus-clomiphene-citrate-in-managing-symptoms-of-hypogonadism-in-men
#14
Pranav Dadhich, Ranjith Ramasamy, Jason Scovell, Nathan Wilken, Larry Lipshultz
INTRODUCTION: Both clomiphene citrate (CC) and testosterone supplementation therapy (TST) are effective treatments for men with hypogonadism. We sought to compare changes in symptoms and treatment efficacy in hypogonadal men before and after receiving CC and TST. PATIENTS AND METHODS: 52 men who received TST and 23 men who received CC for symptomatic hypogonadism were prospectively followed for change in hormone levels and symptoms after treatment. These men were also compared to eugonadal men who were not on CC or TST during the same period...
July 2017: Indian Journal of Urology: IJU: Journal of the Urological Society of India
https://www.readbyqxmd.com/read/28715487/serum-variations-of-anti-mullerian-hormone-and-total-testosterone-with-aging-in-healthy-adult-iranian-men-a-population-based-study
#15
Fahimeh Ramezani Tehrani, Mohammad Ali Mansournia, Masoud Solaymani-Dodaran, Sonia Minooee, Fereidoun Azizi
BACKGROUND: Literature proves anti-mullerian hormone (AMH) and total testosterone (TT) as two important reproductive hormones in male development, however evidence regarding age variations of these hormones is lacking. AIMS: To estimate the normal serum AMH values and to assess the age-specific TT levels in men aged 30-70, we conducted the present population-based study. METHODS: A total of 831 healthy eligible men, aged 30-70 years, were recruited from Tehran Lipid and Glucose study cohort...
2017: PloS One
https://www.readbyqxmd.com/read/28713262/effects-of-strength-training-and-anabolic-steroid-in-the-peripheral-nerve-and-skeletal-muscle-morphology-of-aged-rats
#16
Walter Krause Neto, Wellington de A Silva, Adriano P Ciena, Ricardo Aparecido Baptista Nucci, Carlos A Anaruma, Eliane F Gama
Thirty male 20-month-old Wistar rats were divided into groups: IC-initial control (n = 6), FC-final control (n = 6), AC-anabolic hormone control (n = 6), ST-strength trained (n = 6) and STA-strength trained with anabolic hormone (n = 6). All groups were submitted to adaptation, familiarization and maximum load carrying test (MLCT). Strength training (6-8×/session with loads of 50%-100% MLCT, 3×/week and pause of 120 s) was performed in ladder climbing (LC) for 15 weeks. The administration of testosterone propionate (TP) was performed 2×/week (10 mg/kg) in animals in the AC and STA groups...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28712786/the-relationship-between-hot-flashes-and-testosterone-recovery-after-12-months-of-androgen-suppression-for-men-with-localised-prostate-cancer-in-the-ascende-rt-trial
#17
M Dosani, W J Morris, S Tyldesley, T Pickles
AIMS: This study describes the proportion of men who experienced hot flashes (flashes), and the testosterone level at onset, peak frequency and cessation of flashes after 12 months of androgen deprivation therapy (ADT) in men undergoing curative-intent external beam radiation therapy (± brachytherapy boost). We also aimed to characterise testosterone recovery in this population. MATERIALS AND METHODS: This was a pre-specified secondary analysis of the ASCENDE-RT clinical trial...
July 13, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28710978/relationships-between-pops-biometrics-and-circulating-steroids-in-male-polar-bears-ursus-maritimus-from-svalbard
#18
Tomasz M Ciesielski, Ingunn Tjelta Hansen, Jenny Bytingsvik, Martin Hansen, Elisabeth Lie, Jon Aars, Bjørn M Jenssen, Bjarne Styrishave
The aim of this study was to determine the effects of persistent organic pollutants (POPs) and biometric variables on circulating levels of steroid hormones (androgens, estrogens and progestagens) in male polar bears (Ursus maritimus) from Svalbard, Norway (n = 23). Levels of pregnenolone (PRE), progesterone (PRO), androstenedione (AN), dehydroepiandrosterone (DHEA), testosterone (TS), dihydrotestosterone (DHT), estrone (E1), 17α-estradiol (αE2) and 17β-estradiol (βE2) were quantified in polar bear serum by gas chromatography tandem mass spectrometry (GC-MS/MS), while POPs were measured in plasma...
July 12, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28708528/competition-for-oestrous-ewes-between-rams-reared-by-their-mothers-or-artificially-reared-effects-on-sexual-behaviour-and-testosterone-and-cortisol-serum-concentrations
#19
J P Damián, M J Hötzel, G Banchero, R Ungerfeld
The objective of this study was to determine how the social competition for an oestrous ewe affects the sexual behaviour and the endocrine response in two groups of rams, one reared by their mothers and another artificially reared. Thus, we compared the sexual behaviour and testosterone and cortisol changes in each group of rams in competitive and non-competitive tests, both during the first and second breeding seasons. Two groups of rams were: 1) artificially reared lambs, separated from their dams 24-36 h after birth (Week 0) and artificially fed with sheep milk until 10 weeks of age (group AR, n = 14); and 2) lambs reared by their dams until 10 weeks of age (group DR, n = 13)...
June 8, 2017: Theriogenology
https://www.readbyqxmd.com/read/28708508/developmental-changes-in-the-histological-structure-of-the-testes-and-testosterone-profiles-in-male-guinea-fowls-numida-meleagris
#20
Iddriss I Abdul-Rahman, Frederick Y Obese, Ian A Jeffcoate
Owing to the paucity of information on the reproductive biology of guinea fowls, a study involving a total of 66 males was conducted, and documented the developmental changes in histological structure of the testes of guinea cocks from hatching until adulthood. Changes in testosterone synthesis during sexual development were also determined. Age-related changes were analysed using univariate analysis for completely randomised design and means separated using Tukey's test/Kruskal-Wallis test and medians separated by Mann-Whitney U test...
June 23, 2017: Theriogenology
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