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Testosterone and aging

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https://www.readbyqxmd.com/read/29454168/genetic-and-environmental-influences-on-pubertal-hormones-in-human-hair-across-development
#1
Andrew D Grotzinger, Daniel A Briley, Laura E Engelhardt, Frank D Mann, Megan W Patterson, Jennifer L Tackett, Elliot M Tucker-Drob, K Paige Harden
Puberty is a complex biopsychosocial process that can affect an array of psychiatric and medical disorders emerging in adolescence. Although the pubertal process is driven by neuroendocrine changes, few quantitative genetic studies have directly measured puberty-relevant hormones. Hair samples can now be assayed for accumulation of hormones over several months. In contrast to more conventional salivary measures, hair measures are not confounded by diurnal variation or hormonal reactivity. In an ethnically and socioeconomically diverse sample of 1286 child and adolescent twins and multiples from 672 unique families, we estimated genetic and environmental influences on hair concentrations of testosterone, DHEA, and progesterone across the period of 8-18 years of age...
February 12, 2018: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/29453817/endocrine-and-psychological-aspects-of-sexual-dysfunction-in-klinefelter-patients
#2
A Ferlin, R Selice, S Angelini, M Di Grazia, N Caretta, F Cavalieri, A Di Mambro, C Foresta
Klinefelter syndrome is a frequent cause of hypogonadism, but despite hundreds of publications on different aspects of Klinefelter syndrome, only a few studies dealt with sexual dysfunction. In particular, testosterone is critical for various aspects of sexual response, but its role on sexuality in Klinefelter syndrome patients is debatable and no studies have evaluated the efficacy of testosterone treatment on sexual dysfunction in these subjects. Furthermore, the impact of psychological and relational aspects on sexual function of Klinefelter syndrome subjects is poorly defined...
February 17, 2018: Andrology
https://www.readbyqxmd.com/read/29446828/novel-insights-on-testicular-volume-and-testosterone-replacement-therapy-in-klinefelter-patients-undergoing-testicular-sperm-extraction-a-retrospective-clinical-study
#3
Andrea Garolla, Riccardo Selice, Massimo Menegazzo, Umberto Valente, Filiberto Zattoni, Massimo Iafrate, Tommaso Prayer-Galetti, Marina Gardiman Paola, Alberto Ferlin, Andrea Di Nisio, Carlo Foresta
STUDY QUESTION: To investigate whether sperm recovery is related to clinical features, hormone parameters and testosterone replacement therapy (TRT) in patients with Klinefelter syndrome (KS). SUMMARY ANSWER: This study provides three interesting insights: i) the probability to retrieve sperm is not related to testicular volume; ii) TRT does not affect sperm retrieval rate (SRR); iii) reduced levels of LH and FSH represent a negative predictor of sperm retrieval in patients with TRT...
February 15, 2018: Clinical Endocrinology
https://www.readbyqxmd.com/read/29445518/why-do-endocrine-profiles-in-elite-athletes-differ-between-sports
#4
Peter H Sönksen, Richard I G Holt, Walailuck Böhning, Nishan Guha, David A Cowan, Christiaan Bartlett, Dankmar Böhning
Background: Endocrine profiles have been measured on blood samples obtained immediately post-competition from 693 elite athletes from 15 Olympic Sports competing at National or International level; four were subsequently excluded leaving 689 for the current analysis. Methods: Body composition was measured by bioimpedance in a sub-set of 234 (146 men and 88 women) and from these data a regression model was constructed that enabled 'estimated' lean body mass and fat mass to be calculated on all athletes...
2018: Clinical Diabetes and Endocrinology
https://www.readbyqxmd.com/read/29442076/erectile-dysfunction-is-associated-with-subclinical-carotid-vascular-disease-in-young-men-lacking-widely-known-risk-factors
#5
Feng-Juan Yao, Ya-Dong Zhang, Zi Wan, Wei Li, Hong Lin, Chun-Hua Deng, Yan Zhang
This study aimed to gain insight into the underlying pathogenesis of erectile dysfunction in young men under the age of 40 years without widely-known risk factors. Compared with normal controls, patients with erectile dysfunction had increased carotid intima-media thickness, fasting levels of blood glucose and insulin, and homeostatic model assessment index, as well as lower flow-mediated vasodilation and testosterone levels (P < 0.05), though all of these values were within their respective normal range...
February 9, 2018: Asian Journal of Andrology
https://www.readbyqxmd.com/read/29441605/circulating-25-hydroxy-vitamin-d-correlates-with-serum-level-of-anti-m%C3%A3-llerian-hormone-in-male-patients-with-chronic-kidney-disease
#6
F F Abdel Hamid, A F Soliman, F E S Lashin
This study was designed to assess the relationship between serum levels of anti-Müllerian hormone and 25-hydroxy vitamin D in chronic kidney disease male patients. For that, serum 25-hydroxy vitamin D and anti-Müllerian hormone along with follicle-stimulating hormone, luteinising hormone, prolactin, total testosterone and estradiol were assayed in 59 patients with different stages of chronic kidney disease and 21 healthy participants. Compared to controls, serum levels of anti-Müllerian hormone and 25-hydroxy vitamin D were significantly decreased in patients with chronic kidney disease...
February 14, 2018: Andrologia
https://www.readbyqxmd.com/read/29437023/serum-dhea-s-testosterone-and-cortisol-levels-in-female-patients-with-schizophrenia
#7
Suheyla Dogan Bulut, Serdar Bulut, Ayse G Gundogmus, Cigdem Aydemir
OBJECTIVE: Recent studies have shown that sex hormones play a role in the development of schizophrenia and the severity of disease symptoms. However, study results have been inconsistent. This study compares the relationship between the severity of disease symptoms and levels of testosterone, and DHEA-S and cortisol in premenopausal female patients with schizophrenia and a matched group of healthy controls. METHODS: The study sample included 32 women who were diagnosed as having schizophrenia according to DSM-IV TR criteria, and 32 age- and sex-matched healthy controls...
February 11, 2018: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/29436770/a-review-of-the-role-of-estrogen-in-dermal-aging-and-facial-attractiveness-in-women
#8
REVIEW
Edwin D Lephart
Estrogens are known to have protective and favorable influences on skin health; conversely, androgens oppose the actions of estrogens. Estrogen's chemical messages are transmitted via the classical nuclear hormone estrogen receptors (ER) alpha and beta and the rapid-acting G-coupled membrane estrogen receptor. Androgens [both testosterone and 5α-dihydrotestosterone (5α-DHT)] bind the same androgen receptor. Estrogen levels peak in the mid- to late 20s in women and then decline by 50% by 50 years of age and dramatically decrease further after menopause...
February 13, 2018: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29430665/health-related-physical-fitness-and-quality-of-life-in-men-with-congenital-hypogonadotropic-hypogonadism
#9
K S L Mileski, M Bottaro, L G Grossi-Porto, A Lofrano-Porto
Congenital hypogonadotropic hypogonadism is a rare disorder characterised by impaired testosterone secretion since birth, and represents a valuable model for studying the effects of testosterone replacement therapy (TRT) in humans. This cross-sectional study aimed to investigate all health-related physical fitness (HRPF) components and quality of life in a series of eight men with hypogonadotropic hypogonadism under regular TRT. The study group was compared to a control group of 16 healthy subjects paired for age, body mass index and physical activity...
February 11, 2018: Andrologia
https://www.readbyqxmd.com/read/29428315/association-of-testosterone-and-antim%C3%A3-llerian-hormone-with-time-to-pregnancy-and-pregnancy-loss-in-fecund-women-attempting-pregnancy
#10
Lindsey A Sjaarda, Sunni L Mumford, Daniel L Kuhr, Tiffany L Holland, Robert M Silver, Torie C Plowden, Neil J Perkins, Enrique F Schisterman
OBJECTIVE: To examine whether higher T and/or antimüllerian hormone (AMH) was associated with anovulation, time to pregnancy (TTP), or pregnancy loss risk among healthy, fecund women without diagnosed polycystic ovary syndrome. DESIGN: Prospective cohort study conducted as a secondary analysis from the Effects of Aspirin in Gestation and Reproduction randomized trial. SETTING: University medical centers. PATIENT(S): A total of 1,198 healthy, eumenorrheic women aged 18-40 years attempting spontaneous pregnancy with one to two prior pregnancy losses were included...
February 7, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29426273/testosterone-and-cortisol-secreting-oncocytic-adrenocortical-adenoma-in-the-pediatric-age-group
#11
Maryam K Al Badi, Ibrahim Al-Alwan, Mohammed Al-Dubayee, Ayed Al-Anzi, Maram S Al Turki, Noura Aloudah, Khaled O Alsaad
Oncocytic tumors are epithelial neoplasms that occur in various organs, including adrenal glands. Oncocytic adrenocortical adenomas and carcinomas are uncommon but well-known pathological entities in adults. However, generally oncocytic tumors, particularly in the adrenal glands, are very rare in the pediatric age-group. Most oncocytic adrenal tumors are not functional. We present a rare case of right-sided, functional oncocytic adrenocortical adenoma in a 5-year-old boy, who presented with clinical manifestations of precocious puberty and Cushing syndrome...
January 1, 2018: Pediatric and Developmental Pathology
https://www.readbyqxmd.com/read/29425971/competition-stage-influences-perceived-performance-but-does-not-affect-rating-of-perceived-exertion-and-salivary-neuro-endocrine-immune-markers-in-elite-young-basketball-players
#12
Ademir Felipe Schultz de Arruda, Marcelo Saldanha Aoki, Ana Carolina Paludo, Gustavo Drago, Alexandre Moreira
This study examined the effects of competition stage on the salivary concentration of testosterone (T), cortisol (C), alpha-amylase (sAA), and IL-1ß cytokine, perceived performance (PP) and session rating of perceived exertion (session-RPE) in elite youth basketball players (age, 15.8 ± 0.8 yrs.; stature, 190.9 ± 7.9 cm; body mass, 90.0 ± 16.9 kg) from two age-categories (U16; n = 7; U17; n = 7). Two winning playoff matches (FM; playing for the championship; 1 for each age-category) and two winning regular stage matches (RM; 1 for each age category, played against opponents ranked 2nd place), were assessed in the current study...
February 6, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29425664/topical-testosterone-therapy-adherence-and-outcomes-among-men-with-primary-or-secondary-hypogonadism
#13
Michael Grabner, Zsolt Hepp, Amit Raval, Fang Tian, Mohit Khera
BACKGROUND: Men with primary or secondary hypogonadism (HG) prescribed testosterone therapy (TTh) who terminate treatment early might not obtain the benefit of symptom relief. AIM: To estimate adherence to topical TTh and to compare baseline characteristics and follow-up outcomes between adherent and non-adherent patients in a population of commercially insured US men with primary or secondary HG. METHODS: A retrospective cohort of adult men with primary or secondary HG and initiating topical TTh from 2007 through 2014, with continuous coverage during 12-month baseline and follow-up periods, was identified from a large US health plan...
February 2018: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/29423966/international-investigation-of-neurocognitive-and-behavioral-phenotype-in-47-xxy-klinefelter-syndrome-predicting-individual-differences
#14
Carole Samango-Sprouse, Emily Stapleton, Selena Chea, Patrick Lawson, Teresa Sadeghin, Chris Cappello, Leo de Sonneville, Sophie van Rijn
47,XXY (KS) occurs in 1:650 male births, though less than 25% are ever identified. We assessed stability of neurocognitive features across diverse populations and quantified factors mediating outcome. Forty-four boys from the Netherlands (NL) and 54 boys from the United States (US) participated. The Wechsler Intelligence Scales assessed intellectual functioning; the ANT program evaluated cognitive function; and the CBCL assessed behavioral functioning. ANOVA was used for group comparisons. Hierarchical regressions assessed variance explained by each independent variable: parental education, timing of diagnosis, testosterone, age, and nationality...
February 9, 2018: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/29423028/increased-risk-of-testis-failure-in-testicular-germ-cell-tumor-survivors-undergoing-radiotherapy
#15
Marco Ghezzi, Luca De Toni, Pierfrancesco Palego, Massimo Menegazzo, Elisa Faggian, Massimiliano Berretta, Francesco Fiorica, Maurizio De Rocco Ponce, Carlo Foresta, Andrea Garolla
Testicular germ cell tumors (TGCTs) are prevalent in males of reproductive age. Among the available therapeutic choices, pelvic radiotherapy (RT) and simple surveillance (SURV) are usually pursued. However, RT is considered to have life-threatening effects on testicular functions. In this study we sought to clarify this issue by evaluating sperm parameters and sex hormones in 131 TGCTs RT-treated-patients at both baseline (T0) and 12 (T1) and 24 months (T2) of follow-up. An age-matched group of 61 SURV patients served as control...
January 9, 2018: Oncotarget
https://www.readbyqxmd.com/read/29420188/human-3beta-hydroxysteroid-dehydrogenase-deficiency-associated-with-normal-spermatic-numeration-despite-a-severe-enzyme-deficit
#16
Bruno Donadille, Muriel Houang, Irene Netchine, Jean-Pierre Siffroi, Sophie Christin-Maitre
Human 3 beta-hydroxysteroid dehydrogenase deficiency (3b-HSD) is a very rare form of congenital adrenal hyperplasia resulting from HSD3B2 gene mutations. Its estimated prevalence is less than 1/1,000,000 male neonates. It leads to steroidogenesis impairment in both adrenals and gonads. Few data are available on adult testicular function in such patients. Therefore, we evaluated gonadal axis and testicular function in a 46,XY adult patient, carrying a HSD3B2 mutation. The patient presented at birth with neonatal salt wasting syndrome, a micropenis, perineal hypospadias and intrascrotal testes...
February 2, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29417657/digit-ratio-2d-4d-in-chinese-women-with-gastric-cancer
#17
Lu Wang, Hong Lu, Ke-Ke Li, Chun-Yue Bai, Zhan-Bing Ma
OBJECTIVES: Digit ratio, especially the second-to-fourth digit ratio (2D:4D), is a proxy indicator for prenatal exposure and sensitivity to sexual hormones which may influence the susceptibility to certain cancers. The aim of the present study was to investigate whether there is a possible association between 2D:4D and gastric cancer (GCA) in north Chinese women. METHODS: Photographs of the left and right hands of 167 women (controls: 113; patients: 54) were collected...
February 8, 2018: American Journal of Human Biology: the Official Journal of the Human Biology Council
https://www.readbyqxmd.com/read/29417486/the-change-in-the-percent-of-android-and-gynoid-fat-mass-correlated-with-increased-testosterone-after-laparoscopic-sleeve-gastrectomy-in-chinese-obese-men-a-6-month-follow-up
#18
Jingyang Gao, Manna Zhang, Cuiling Zhu, Yi Zhang, Qi Liu, Xingchun Wang, Liang Li, Donglei Zhou, Shen Qu
OBJECTIVE: The study was designed to examine changes of body fat distribution after laparoscopic sleeve gastrectomy (LSG) in obese male patients and to confirm whether these changes are correlated with increased testosterone. METHODS: A total of 30 obese male patients with body mass index (BMI) 30-45 kg/m2 were enrolled in this study. Data on demographic characteristics, anthropometry, metabolic parameters, and body fat distribution were collected at baseline and 6 months after LSG...
February 7, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29413225/microdissection-testicular-sperm-extraction-micro-tese-predictive-value-of-preoperative-hormonal-levels-and-pathology-in-non-obstructive-azoospermia
#19
Alper Eken, Feray Gulec
The aim of this study was to evaluate the predictive value of preoperative hormonal levels and pathology, as well as the outcome of microsurgical testicular sperm extraction in patients with non-obstructive azoospermia (NOA), presenting to our clinic for treatment of infertility. The records of 145 men with NOA who underwent microdissection testicular sperm extraction (micro-TESE) between March 2013 and November 2016 were studied. The patient's age, testicular volume, hormonal profile for follicle-stimulating hormone (FSH), luteinizing hormone (LH), and testosterone (TT), and testicular pathology were recorded...
February 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29412390/growth-hormone-deficiency-with-advanced-bone-age-phenotypic-interaction-between-ghrh-receptor-and-cyp21a2-mutations-diagnosed-by-sanger-and-whole-exome-sequencing
#20
Fernanda A Correa, Marcela M França, Qing Fang, Qianyi Ma, Tania A Bachega, Andresa Rodrigues, Bilge A Ozel, Jun Z Li, Berenice B Mendonca, Alexander A L Jorge, Luciani R Carvalho, Sally A Camper, Ivo J P Arnhold
Isolated growth hormone deficiency (IGHD) is the most common pituitary hormone deficiency and, clinically, patients have delayed bone age. High sequence similarity between CYP21A2 gene and CYP21A1P pseudogene poses difficulties for exome sequencing interpretation. A 7.5 year-old boy born to second-degree cousins presented with severe short stature (height SDS -3.7) and bone age of 6 years. Clonidine and combined pituitary stimulation tests revealed GH deficiency. Pituitary MRI was normal. The patient was successfully treated with rGH...
December 2017: Archives of Endocrinology and Metabolism
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