keyword
MENU ▼
Read by QxMD icon Read
search

Loss memory

keyword
https://www.readbyqxmd.com/read/29240990/wnt-signaling-loss-accelerates-the-appearance-of-neuropathological-hallmarks-of-alzheimer-s-disease-in-j20-app-transgenic-and-wild-type-mice
#1
Cheril Tapia-Rojas, Nibaldo C Inestrosa
Alzheimer's disease (AD) is a neurodegenerative pathology characterized by aggregates of amyloid-β (Aβ) and phosphorylated tau protein, synaptic dysfunction, and spatial memory impairment. The Wnt signaling pathway has several key functions in the adult brain and has been associated with AD, mainly as a neuroprotective factor against Aβ toxicity and tau phosphorylation. However, dysfunction of Wnt/β-catenin signaling might also play a role in the onset and development of the disease. J20 APPswInd transgenic (Tg) mouse model of AD was treated i...
December 14, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29238983/brain-volume-changes-in-hyposmic-patients-before-and-after-olfactory-training
#2
Janine Gellrich, Pengfei Han, Cedric Manesse, Amelie Betz, Anne Junghanns, Claudia Raue, Valentin A Schriever, Thomas Hummel
OBJECTIVES/HYPOTHESIS: Olfactory dysfunction is thought to be associated with reduced gray matter (GM) volume in olfactory-related brain areas. The aim of this study was to determine GM structural changes within olfactory-related regions of the brain in patients with smell loss due to upper respiratory tract infection (URTI) before and after olfactory rehabilitation. STUDY DESIGN: Prospective intervention case-control study. METHODS: Magnetic resonance imaging structural brain images were collected from 30 patients with smell loss due to URTI and 31 controls...
December 14, 2017: Laryngoscope
https://www.readbyqxmd.com/read/29237665/intermittent-catatonia-and-complex-automatisms-caused-by-frontal-lobe-epilepsy-in-dementia
#3
Robynne George, Alex Langford
An 82-year-old man was admitted to the emergency department following bizarre behaviour. Police had noticed him driving erratically through his village. He did not stop when instructed, drove slowly home and appeared 'vacant' on questioning. While in hospital, he had approximately 15 episodes of catatonia, involving rigidity, negativism, mutism except echolalia and perseveration, automatic obedience and utilisation phenomena, lasting 2-20 min each. Between episodes, he was amnestic but otherwise well. Electroencephalography demonstrated bifrontal slowing with left-sided emphasis, and captured two focal onset partial seizures with the clinical correlate of the syndrome described above...
December 13, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/29237334/the-association-between-cognitive-performance-and-speech-in-noise-perception-for-adult-listeners-a-systematic-literature-review-and-meta-analysis
#4
Adam Dryden, Harriet A Allen, Helen Henshaw, Antje Heinrich
Published studies assessing the association between cognitive performance and speech-in-noise (SiN) perception examine different aspects of each, test different listeners, and often report quite variable associations. By examining the published evidence base using a systematic approach, we aim to identify robust patterns across studies and highlight any remaining gaps in knowledge. We limit our assessment to adult unaided listeners with audiometric profiles ranging from normal hearing to moderate hearing loss...
January 2017: Trends in Hearing
https://www.readbyqxmd.com/read/29234406/amelioration-of-scopolamine-induced-learning-and-memory-impairment-by-%C3%AE-pinene-in-c57bl-6-mice
#5
Gil-Yong Lee, Chan Lee, Gyu Hwan Park, Jung-Hee Jang
Increasing evidence suggests that neurodegenerative disorders such as Alzheimer's disease (AD) are mediated via disruption of cholinergic neurons and enhanced oxidative stress. Therefore, attention has been focused on searching for antioxidant phytochemicals for the prevention and/or treatment of AD through their ability to fortify cholinergic function and antioxidant defense capacity. In this study, we have investigated the neuroprotective effect of α-pinene (APN) against learning and memory impairment induced by scopolamine (SCO, 1 mg/kg, i...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29232315/beneficial-effects-of-exercise-pretreatment-in-a-sporadic-alzheimer-s-rat-model
#6
Chongyun Wu, Luodan Yang, Donovan Tucker, Yan Dong, Ling Zhu, Rui Duan, Timon Cheng-Yi Liu, Quanguang Zhang
PURPOSE: This study aimed to examine the effects of swimming exercise pretreatment on a streptozotocin (STZ)-induced sporadic Alzheimer's disease rat model and provide an initial understanding of related molecular mechanisms. METHODS: Male 2.5-month-old Sprague-Dawley rats were divided into the following 4 groups: a) control, b) swim + vehicle, c) STZ without swim, and d) swim + STZ. The Barnes Maze task and Novel Object Recognition test were used to measure hippocampus-dependent spatial learning and working memory, respectively...
December 11, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29232252/nicotinamide-adenine-dinucleotide-and-its-related-precursors-for-the-treatment-of-alzheimer-s-disease
#7
Nady Braidy, Ross Grant, Perminder S Sachdev
PURPOSE OF REVIEW: The current review discusses the biology and metabolism of the essential pyridine nucleotide nicotinamide adenine dinucleotide (NAD+) in the central nervous system. We also review recent work suggesting important neuroprotective effects that may be associated with the promotion of NAD+ levels through NAD+ precursors against Alzheimer's disease. RECENT FINDINGS: Perturbations in the physiological homoeostatic state of the brain during the ageing process can lead to impaired cellular function, and ultimately leads to loss of brain integrity and accelerates cognitive and memory decline...
December 9, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/29230660/dietary-intake-of-soy-and-cruciferous-vegetables-and-treatment-related-symptoms-in-chinese-american-and-non-hispanic-white-breast-cancer-survivors
#8
Sarah J O Nomura, Yi-Ting Hwang, Scarlett Lin Gomez, Teresa T Fung, Shu-Lan Yeh, Chiranjeev Dash, Laura Allen, Serena Philips, Leena Hilakivi-Clarke, Yun-Ling Zheng, Judy Huei-Yu Wang
PURPOSE: This project was undertaken to examine the association between dietary intake of soy or cruciferous vegetables and breast cancer treatment-related symptoms among Chinese-American (CA) and Non-Hispanic White (NHW) breast cancer survivors. METHODS: This cross-sectional study included 192 CA and 173 NHW female breast cancer survivors (stages 0-III, diagnosed between 2006 and 2012) recruited from two California cancer registries, who had completed primary treatment...
December 11, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29230507/evidence-for-regional-hippocampal-damage-in-patients-with-schizophrenia
#9
Sadhana Singh, Subash Khushu, Pawan Kumar, Satnam Goyal, Triptish Bhatia, Smita N Deshpande
PURPOSE: Schizophrenia patients show cognitive and mood impairments, including memory loss and depression, suggesting damage in the brain regions. The hippocampus is a brain structure that is significantly involved in memory and mood function and shows impairment in schizophrenia. In the present study, we examined the regional hippocampal changes in schizophrenia patients using voxel-based morphometry (VBM), Freesurfer, and proton magnetic resonance spectroscopy (1H MRS) procedures. METHODS: 1H MRS and high-resolution T1-weighted magnetic resonance imaging were collected in both healthy control subjects (N = 28) and schizophrenia patients (N = 28) using 3-Tesla whole body MRI system...
December 11, 2017: Neuroradiology
https://www.readbyqxmd.com/read/29229786/seed-induced-a%C3%AE-deposition-is-modulated-by-microglia-under-environmental-enrichment-in-a-mouse-model-of-alzheimer-s-disease
#10
Stephanie Ziegler-Waldkirch, Paolo D Errico, Jonas-Frederic Sauer, Daniel Erny, Shakuntala Savanthrapadian, Desirée Loreth, Natalie Katzmarski, Thomas Blank, Marlene Bartos, Marco Prinz, Melanie Meyer-Luehmann
Alzheimer's disease (AD) is characterized by severe neuronal loss as well as the accumulation of amyloid-β (Aβ), which ultimately leads to plaque formation. Although there is now a general agreement that the aggregation of Aβ can be initiated by prion-like seeding, the impact and functional consequences of induced Aβ deposits (Aβ seeding) on neurons still remain open questions. Here, we find that Aβ seeding, representing early stages of plaque formation, leads to a dramatic decrease in proliferation and neurogenesis in two APP transgenic mouse models...
December 11, 2017: EMBO Journal
https://www.readbyqxmd.com/read/29229413/constant-light-environment-suppresses-maturation-and-reduces-complexity-of-new-born-neuron-processes-in-the-hippocampus-and-caudal-nidopallium-of-a-diurnal-corvid-implication-for-impairment-of-the-learning-and-cognitive-performance
#11
S K Tahajjul Taufique, Abhilash Prabhat, Vinod Kumar
Periodic day-night environment shapes the temporal pattern in the behaviour and physiology (e.g. 24-h activity-rest and sleep-wake cycles) and the advanced brain function, such as learning, memory and decision making. In a previous study, we showed the abolition of 24-h rhythm in the activity-rest pattern, and an attenuated cognitive performance in diurnal Indian house crows (Corvus splendens) under constant light (no-night; LL) environment. Present study extended this, and investigated LL-induced effects on the neurogenesis (birth, maturation and neurite complexity of new born neurons) in the hippocampus and caudal nidopallium, the brain regions directly associated with learning and cognition in birds...
December 8, 2017: Neurobiology of Learning and Memory
https://www.readbyqxmd.com/read/29229011/making-sense-of-loss-through-spirituality-perspectives-of-african-american-family-members-who-have-experienced-the-death-of-a-close-family-member-to-cancer
#12
Jill B Hamilton, Nakia C Best, Jessica S Wells, Valarie C Worthy
OBJECTIVE: Among African Americans, spirituality is meaning or purpose in life and a faith in God who is in control of health and there to provide support and guidance in illness situations. Using qualitative methods, we explored the use of spirituality to make sense of the end-of-life and bereavement experiences among family members of a deceased cancer patient. METHOD: Data in this report come from 19 African Americans who experienced the loss of a family member to cancer...
December 12, 2017: Palliative & Supportive Care
https://www.readbyqxmd.com/read/29228757/disrupted-functional-connectivity-between-perirhinal-and-parahippocampal-cortices-with-hippocampal-subfields-in-patients-with-mild-cognitive-impairment-and-alzheimer-s-disease
#13
Yu Sun, Yafei Wang, Jiaming Lu, Rengyuan Liu, Christopher G Schwarz, Hui Zhao, Yue Zhang, Lingyi Xu, Bin Zhu, Bing Zhang, Bing Liu, Suiren Wan, Yun Xu
Most patients with mild cognitive impairment and Alzheimer's disease can initially present memory loss. The medial temporal lobes are the brain regions most associated with declarative memory function. As sub-components of the MTL, the perirhinal cortex, parahippocampal cortex and hippocampus have also been identified as playing important roles in memory. The functional connectivity between hippocampus subfields and perirhnial cortices as well as parahippocampal cortices among normal cognition controls (NC group, n=33), mild cognitive impairment (MCI group, n=31) and Alzheimer's disease (AD group, n=27) was investigated in this study...
November 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226675/ferroelectric-polarization-modulated-interfacial-fine-structures-involving-two-dimensional-electron-gases-in-pb-zr-ti-o3-laalo3-srtio3-heterostructures
#14
Shuangbao Wang, Yuhang Bai, Lin Xie, Chen Li, Julian Key, Di Wu, Peng Wang, Xiaoqing Pan
Interfacial fine structures of bare LaAlO3/SrTiO3 (LAO/STO) heterostructures are compared with those of LAO/STO heterostructures capped with upward-polarized Pb(Zr0.1, Ti0.9)O3 (PZTup) or downward-polarized Pb(Zr0.5, Ti0.5)O3 (PZTdown) overlayers by aberration-corrected scanning transmission electron microscopy experiments. By combing the acquired electron energy-loss spectroscopy mapping, we are able to directly observe electron transfer from Ti4+ to Ti3+ and ionic displacements at the interface of bare LAO/STO and PZTdown/LAO/STO heterostructures unit cell by unit cell...
December 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29225190/scopolamine-induced-passive-avoidance-memory-retrieval-deficit-is-accompanied-with-hippocampal-mmp2-mmp-9-and-mapks-alteration
#15
Maryam Moosavi, Roksana SoukhakLari, Leila Moezi, Fatema Pirsalami
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive loss of memory and cognitive deficit. The observed amnesia in the early stages of AD is suggested to be a retrieval problem, rather than encoding and consolidation deficit. According to the cholinergic hypothesis of AD, scopolamine is used to induce an animal model of amnesia. Howbeit the effect of scopolamine on memory retrieval is contradictory. This study aimed to assess the effect of scopolamine on passive avoidance memory retrieval...
December 7, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29223596/presence-and-persistence-of-the-amnesic-shellfish-poisoning-toxin-domoic-acid-in-octopus-and-cuttlefish-brains
#16
Vanessa M Lopes, Rui Rosa, Pedro R Costa
Domoic acid (DA) is a neurotoxin that causes degenerative damage to brain cells and induces permanent short-term memory loss in mammals. In cephalopod mollusks, although DA is known to accumulate primarily in the digestive gland, there is no knowledge whether DA reaches their central nervous system. Here we report, for the first time, the presence of DA in brain tissue of the common octopus (Octopus vulgaris) and the European cuttlefish (Sepia officinalis), and its absence in the brains of several squid species (Loligo vulgaris, L...
December 5, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/29222566/motivation-to-address-self-reported-hearing-problems-in-adults-with-normal-hearing-thresholds
#17
Carly C M Alicea, Karen A Doherty
Purpose: The purpose of this study was to compare the motivation to change in relation to hearing problems in adults with normal hearing thresholds but who report hearing problems and that of adults with a mild-to-moderate sensorineural hearing loss. Factors related to their motivation were also assessed. Method: The motivation to change in relation to self-reported hearing problems was measured using the University of Rhode Island Change Assessment (McConnaughy, Prochaska, & Velicer, 1983)...
December 8, 2017: Journal of Speech, Language, and Hearing Research: JSLHR
https://www.readbyqxmd.com/read/29221639/nerve-growth-factor-released-from-collagen-scaffolds-protects-axotomized-cholinergic-neurons-of-the-basal-nucleus-of-meynert-in-organotypic-brain-slices
#18
Bettina M Foidl, Buket Ucar, Alina Schwarz, Ana L Rebelo, Abhay Pandit, Christian Humpel
BACKGROUND: Alzheimeŕs disease is accompanied by cell death of cholinergic neurons, resulting in cognitive impairment and memory loss. Nerve growth factor (NGF) is the most potent protein to support survival of cholinergic neurons. New METHOD: Organotypic brain slices of the basal nucleus of Meynert (nBM) are a valuable tool to study cell death of axotomized cholinergic neurons, as well as protective effects of NGF added into the medium. The aim of the present study is to use collagen scaffolds crosslinked with polyethylineglycole and load with NGF to target delivery of NGF to organotypic nBM brain slices...
December 5, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29221166/high-salt-induced-hypertension-leads-to-cognitive-defect
#19
Cui-Ping Guo, Zhen Wei, Fang Huang, Min Qin, Xing Li, Yu-Man Wang, Qun Wang, Jian-Zhi Wang, Rong Liu, Bin Zhang, Hong-Lian Li, Xiao-Chuan Wang
Although increasing evidences suggest a relationship between hypertension and brain function for years, it is still unclear whether hypertension constitutes a risk factor for cognitive decline and its underlying mechanism. In the present study, an experimental animal model of hypertension simply by feeding rats with high salt diet was employed. We found that long-term high salt intake caused a marked increase of systolic blood pressure linked to a declined regional cerebral blood flow. Fear conditioning and morris water maze behavioral test revealed that high salt diet induced hippocampal dependent spatial reference memory deficits, while a decreased synaptogenesis without neuronal loss in hippocampus was observed in high salt treated rats...
November 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29218394/modulation-of-sphingosine-1-phosphate-s1p-attenuates-spatial-learning-and-memory-impairments-in-the-valproic-acid-rat-model-of-autism
#20
Hongmei Wu, Quanzhi Zhang, Jingquan Gao, Caihong Sun, Jia Wang, Wei Xia, Yonggang Cao, Yanqiu Hao, Lijie Wu
RATIONALE: Autism spectrum disorders (ASD) are a set of pervasive neurodevelopmental disorders that manifest in early childhood, and it is growing up to be a major cause of disability in children. However, the etiology and treatment of ASD are not well understood. In our previous study, we found that serum levels of sphingosine 1-phosphate (S1P) were increased significantly in children with autism, indicating that S1P levels may be involved in ASD. OBJECTIVE: The objective of this study was to identify a link between increased levels of S1P and neurobehavioral changes in autism...
December 7, 2017: Psychopharmacology
keyword
keyword
57773
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"