Haneen T Salah, Richard K Yang, Sinchita Roy-Chowdhuri, Merrick I Ross, Phyu P Aung, Aimi T Rothrock, Carlos A Torres-Cabala, Jonathan L Curry, Victor G Prieto, Priyadharsini Nagarajan, Woo Cheal Cho
ALK-fused Spitz melanocytic neoplasms are a distinct subgroup of melanocytic lesions exhibiting unique histopathologic characteristics. These lesions often manifest as exophytic or polypoid tumors, characterized by fusiform-to-epithelioid melanocytes arranged in a nested, fascicular, or plexiform growth pattern. Several fusion partners of the ALK gene have been identified in spitzoid melanocytic neoplasms, with TPM3 and DCTN1 being the most prevalent. Less common fusion partners include NPM1, TPR, CLIP1, GTF3C2, EEF2, MYO5A, KANK1, and EHBP1...
March 5, 2024: Journal of Cutaneous Pathology