Grace A Hile, Patrick Coit, Bin Xu, Amanda M Victory, Mehrnaz Gharaee-Kermani, Shannon N Estadt, Mitra P Maz, Jacob W S Martens, Rachael Wasikowski, Craig Dobry, Lam C Tsoi, Ramiro Iglesias-Bartolome, Celine C Berthier, Allison C Billi, Johann E Gudjonsson, Amr H Sawalha, J Michelle Kahlenberg
OBJECTIVE: Photosensitivity is one of the most common manifestations of systemic lupus erythematosus (SLE), yet its pathogenesis is not well understood. Normal-appearing epidermis of patients with SLE exhibits increased UVB-driven cell death that persists in cell culture. Here we investigate the role of epigenetic modification and Hippo signaling in enhanced UVB-induced apoptosis seen in SLE keratinocytes. METHODS: DNA methylation was analyzed using bisulfite sequencing from cultured SLE keratinocytes compared to healthy control (n=6, each)...
January 26, 2023: Arthritis & Rheumatology