keyword
https://read.qxmd.com/read/37398932/nop2-mediated-m5c-modification-of-c-myc-in-an-eif3a-dependent-manner-to-reprogram-glucose-metabolism-and-promote-hepatocellular-carcinoma-progression
#21
JOURNAL ARTICLE
Hao Zhang, Xiangyu Zhai, Yanfeng Liu, Zhijia Xia, Tong Xia, Gang Du, Huaxin Zhou, Dorothee Franziska Strohmer, Alexandr V Bazhin, Ziqiang Li, Xianqiang Wang, Bin Jin, Deliang Guo
Mitochondrial dysfunction and glycolysis activation are improtant hallmarks of hepatocellular carcinoma (HCC). NOP2 is an S-adenosyl-L-methionine-dependent methyltransferase that regulates the cell cycle and proliferation activities. In this study, found that NOP2 contributes to HCC progression by promoting aerobic glycolysis. Our results revealed that NOP2 was highly expressed in HCC and that it was associated with unfavorable prognosis. NOP2 knockout in combination with sorafenib enhanced sorafenib sensitivity, which, in turn, led to marked tumor growth inhibition...
2023: Research: a science partner journal
https://read.qxmd.com/read/37375967/agromorphological-and-physiological-performance-of-ethiopian-common-bean-phaseolus-vulgaris-l-genotypes-under-different-agroecological-conditions
#22
JOURNAL ARTICLE
Shiferaw Girsil Tigist, Julia Sibiya, Assefa Amelework, Gemechu Keneni
The objectives of this study were to assess the agronomic performance of common bean genotypes, previously selected for their response to infestation, by Mexican bean weevil and to identify promising lines that can be used as parents in a downstream breeding program. Field experiments were conducted using 144 genotypes under three different agro-ecologies in an unbalanced incomplete block design with three replications. Data on 15 agro-morphological traits were collected, and multivariate methods were used to examine the patterns of variation among the genotypes...
June 16, 2023: Plants (Basel, Switzerland)
https://read.qxmd.com/read/37314832/assessing-the-productivity-of-the-direct-conversion-of-methane-to-methanol-over-copper-exchanged-zeolite-omega-maz-via-oxygen-looping
#23
JOURNAL ARTICLE
Johannes Wieser, Amy J Knorpp, Dragos C Stoian, Przemyslaw Rzepka, Mark A Newton, Jeroen A van Bokhoven
The methane-to-methanol (MtM) conversion via the oxygen looping approach using copper-exchanged zeolites has been extensively studied over the last decade. While a lot of research has focussed on maximizing yield and selectivity, little has been directed toward productivity - a metric far more meaningful for evaluating industrial potential. Using copper-exchanged zeolite omega (Cu-omega), a material highly active and selective for the MtM conversion using the isothermal oxygen looping approach, we show that this material exhibits unprecedented potential for industrial valorization...
June 14, 2023: Angewandte Chemie
https://read.qxmd.com/read/37186587/preclinical-evaluation-of-oncolytic-potential-human-rotavirus-wt-1-5-in-gastric-adenocarcinoma
#24
JOURNAL ARTICLE
Henry Sossa-Rojas, Pedro Gabriel Franco-Maz, Carlos Zapata-Acevedo, Luz Dary Gutierrez-Castañeda, Carlos Guerrero
Despite advances in biomedical research, gastric cancer remains the leading cause of morbidity and mortality worldwide due to the limited efficacy of conventional therapies. In recent decades, oncolytic viruses have emerged as a biological therapeutic alternative to cancer due to their selectivity, effectiveness, and low toxicity. However, clinical trials have shown that developing a virus with selectivity for multiple tumor receptors and the ability to penetrate and diffuse through the tumor microenvironment to reactivate the immune system remains challenging...
2023: PloS One
https://read.qxmd.com/read/37162865/novel-chromatin-insulating-activities-uncovered-upon-eliminating-known-insulators-in-vivo
#25
Havva Ortabozkoyun, Pin-Yao Huang, Hyunwoo Cho, Aristotelis Tsirigos, Esteban Mazzoni, Danny Reinberg
CCCTC-binding factor (CTCF) and MAZ are recognized insulators required for shielding repressed posterior genes from active anterior genes within the Hox clusters during motor neuron (MN) differentiation. CTCF and MAZ interact independently with cohesin and regulate three-dimensional genome organization. Here, we followed cohesin re-location upon CTCF and MAZ depletion in mouse embryonic stem cells (mESCs) to identify novel insulators. Cohesin relocated to DNA motifs for various transcription factors, including PATZ1 and other zinc finger proteins (ZNFs)...
April 25, 2023: bioRxiv
https://read.qxmd.com/read/37150361/gut-microbiota-maturity-mediates-the-protective-effect-of-siblings-on-food-allergy
#26
JOURNAL ARTICLE
Yuan Gao, Jakob Stokholm, Martin O'Hely, Anne-Louise Ponsonby, Mimi Lk Tang, Sarath Ranganathan, Richard Saffery, Leonard C Harrison, Fiona Collier, Lawrence Gray, David Burgner, John Molloy, Peter D Sly, Susanne Brix, Hanne Frøkiær, Peter Vuillermin
BACKGROUND: The mechanisms underlying the protective effect of older siblings on allergic disease remain unclear but may relate to the infant gut microbiota. OBJECTIVE: We investigated whether having older siblings decreases the risk of Immunoglobulin E (IgE)-mediated food allergy by accelerating the maturation of the infant gut microbiota. METHODS: In a birth cohort assembled using an unselected antenatal sampling frame (n=1074), fecal samples were collected at 1 month, 6 months and 1 year, and food allergy status at 1 year was determined by skin prick test and in-hospital food challenge...
May 5, 2023: Journal of Allergy and Clinical Immunology
https://read.qxmd.com/read/37121465/transcriptional-factor-maz-promotes-cisplatin-induced-dna-damage-repair-in-lung-adenocarcinoma-by-regulating-neil3
#27
JOURNAL ARTICLE
Tao Wang, Xu Zhu, Kai Wang, Jianglun Li, Xiao Hu, Peng Lin, Jian Zhang
BACKGROUND: Cisplatin remains a common chemotherapy drug for lung adenocarcinoma (LUAD) in clinical treatment. Long-term use of cisplatin in patients may lead to acquired drug resistance, resulting in poor prognoses of patients. NEIL3 was a glycosylase-encoding gene highly expressed in LUAD. NEIL3 can repair telomerase DNA damage in the S phase. Nevertheless, there are few reports on whether NEIL3 is involved in cisplatin resistance and its related mechanisms in LUAD. METHODS: The expression of NEIL3 in LUAD patients was analyzed by bioinformatics...
April 28, 2023: Pulmonary Pharmacology & Therapeutics
https://read.qxmd.com/read/37101376/chi3l1-is-a-modulator-of-glioma-stem-cell-states-and-a-therapeutic-target-in-glioblastoma
#28
JOURNAL ARTICLE
Charlotte Guetta-Terrier, David Karambizi, Bedia Akosman, John P Zepecki, Jia-Shu Chen, Suchitra Kamle, J Eduardo Fajardo, Andras Fiser, Ritambhara Singh, Steven A Toms, Chun Geun Lee, Jack A Elias, Nikos Tapinos
Chi3l1 (chitinase 3-like 1) is a secreted protein that is highly expressed in glioblastoma. Here, we show that Chi3l1 alters the state of glioma stem cells (GSCs) to support tumor growth. Exposure of patient-derived GSCs to Chi3l1 reduced the frequency of CD133+SOX2+ cells and increased the CD44+Chi3l1+ cells. Chi3l1 bound to CD44 and induced phosphorylation and nuclear translocation of β-catenin, Akt and STAT3. Single cell RNA-seq and RNA velocity following incubation of GSCs with Chi3l1 showed significant changes in GSC state dynamics driving GSCs towards a mesenchymal expression profile and reducing transition probabilities towards terminal cellular states...
April 27, 2023: Cancer Research
https://read.qxmd.com/read/37098909/-rhizobium-phage-like-microvirus-genome-sequence-identified-in-wastewater-in-arizona-usa-in-november-2020-encodes-an-endolysin-and-a-putative-multiheme-cytochrome-c-like-protein
#29
JOURNAL ARTICLE
Ainsley R Chapman, Jillian M Wright, Nicole A Kaiser, Peter M Jones, Erin M Driver, Rolf U Halden, Arvind Varsani, Matthew Scotch, Temitope O C Faleye
We describe the genome (4,696 nucleotides [GC content, 56%; coverage, 3,641×) of MAZ-Nov-2020, a microvirus identified from municipal wastewater in Maricopa County, Arizona, USA, in November 2020. The MAZ-Nov-2020 genome encodes major capsid protein, endolysin, replication initiator protein, and two hypothetical proteins, one of which was predicted to likely be a membrane-associated multiheme cytochrome c .
April 26, 2023: Microbiology Resource Announcements
https://read.qxmd.com/read/37018054/magnetite-azolla-impedimetric-nanobiosensor-for-phthalic-acid-esters-quantification
#30
JOURNAL ARTICLE
Maryam Darvishi, Shahab Shariati, Fariba Safa, Akbar Islamnezhad
Phthalic acid esters (PAEs) are a group of organic compounds that show vulnerability effects in different stages of human development. In this work, two sensitive and efficient impedimetric biosensors (IBs) were introduced and their interactions with four PAEs, namely dibutyl phthalate (DBP), dimethyl phthalate (DMP), di(2-ethylhexyl) phthalate (DEHP), and dicyclohexyl phthalate (DCHP), in aqueous solutions with these biosensors were separately investigated via electrochemical impedance spectroscopy (EIS). The surface of a copper electrode was modified by azolla fern dried powder (AZ) and magnetite-modified azolla nanocomposites (MAZ NCs) to form an azolla-based impedimetric biosensor (AZIB) and magnetite azolla nanocomposite-based impedimetric nanobiosensor (MAZIB), respectively...
April 5, 2023: Analytical Methods: Advancing Methods and Applications
https://read.qxmd.com/read/37013988/probabilistic-establishment-of-speckle-associated-inter-chromosomal-interactions
#31
JOURNAL ARTICLE
Jaegeon Joo, Sunghyun Cho, Sukbum Hong, Sunwoo Min, Kyukwang Kim, Rajeev Kumar, Jeong-Mo Choi, Yongdae Shin, Inkyung Jung
Inter-chromosomal interactions play a crucial role in genome organization, yet the organizational principles remain elusive. Here, we introduce a novel computational method to systematically characterize inter-chromosomal interactions using in situ Hi-C results from various cell types. Our method successfully identifies two apparently hub-like inter-chromosomal contacts associated with nuclear speckles and nucleoli, respectively. Interestingly, we discover that nuclear speckle-associated inter-chromosomal interactions are highly cell-type invariant with a marked enrichment of cell-type common super-enhancers (CSEs)...
April 4, 2023: Nucleic Acids Research
https://read.qxmd.com/read/36988258/tbk1-promotes-thyroid-cancer-progress-by-activating-the-pi3k-akt-mtor-signaling-pathway
#32
JOURNAL ARTICLE
Qiuli Jiang, Yingying Guan, Jingmei Zheng, Huadong Lu
INTRODUCTION: Thyroid cancer has received increasing attention; however, its detailed pathogenesis and pathological processes remain unclear. We investigated the role of TANK-binding kinase 1 (TBK1) in the progression of thyroid cancer. METHODS: The expression of TBK1 in thyroid cancer and normal control tissues was analyzed using real-time quantitative polymerase chain reaction. The function of TBK1 on thyroid cancer cells was detected using MTT, colony formation, wound healing, and Transwell assays...
March 2023: Immunity, Inflammation and Disease
https://read.qxmd.com/read/36927550/analysing-twitter-s-role-in-combating-the-magnetic-vaccine-conspiracy-theory-using-social-network-analysis
#33
JOURNAL ARTICLE
Wasim Ahmed, Ronnie Das, Josep Vidal-Alaball, Mariann Maz Hardey, Aïna Fuster-Casanovas
BACKGROUND: The popularity of the magnetic vaccine conspiracy theory, and others of a similar nature, creates challenges to promoting vaccines and disseminating accurate health information. OBJECTIVE: Health conspiracy theories are gaining in popularity. The study's objective was to evaluate the Twitter social media network related to the magnetic vaccination conspiracy theory and to apply social capital theory to analyse the unique social structures of influential users...
March 10, 2023: Journal of Medical Internet Research
https://read.qxmd.com/read/36924026/senescence-associated-transcriptional-derepression-in-subtelomeres-is-determined-in-a-chromosome-end-specific-manner
#34
JOURNAL ARTICLE
Martin Rey-Millet, Mélanie Pousse, Chan Soithong, Jing Ye, Aaron Mendez-Bermudez, Eric Gilson
Aging is a continuous process leading to physiological deterioration with age. One of the factors contributing to aging is telomere shortening, causing alterations in the protein protective complex named shelterin and replicative senescence. Here, we address the question of the link between this telomere shortening and the transcriptional changes occurring in senescent cells. We found that in replicative senescent cells, the genes whose expression escaped repression are enriched in subtelomeres. The shelterin protein TRF2 and the nuclear lamina factor Lamin B1, both downregulated in senescent cells, are involved in the regulation of some but not all of these subtelomeric genes, suggesting complex mechanisms of transcriptional regulation...
March 15, 2023: Aging Cell
https://read.qxmd.com/read/36890610/pcgf6-max-kdm5d-facilitates-maz-cdk4-axis-expression-and-prcc-progression-by-hypomethylation-of-the-dna-promoter
#35
JOURNAL ARTICLE
Meng Zhu, Ruo-Nan Zhang, Hong Zhang, Chang-Bao Qu, Xiao-Chong Zhang, Li-Xin Ren, Zhan Yang, Jun-Fei Gu
Polycomb group RING finger protein 6 (PCGF6) plays an important role as a regulator of transcription in a variety of cellular processes, including tumorigenesis. However, the function and expression of PCGF6 in papillary RCC (pRCC) remain unclear. In the present study, we found that PCGF6 expression was significantly elevated in pRCC tissues, and high expression of PCGF6 was associated with poor survival of patients with pRCC. The overexpression of PCGF6 promoted while depletion of PCGF6 depressed the proliferation of pRCC cells in vitro...
March 9, 2023: Epigenetics & Chromatin
https://read.qxmd.com/read/36862132/germinal-center-b-cells-that-acquire-nuclear-proteins-are-specifically-suppressed-by-follicular-regulatory-t-cells
#36
JOURNAL ARTICLE
Fang Ke, Zachary L Benet, Mitra P Maz, Jianhua Liu, Alexander L Dent, Joanne Michelle Kahlenberg, Irina L Grigorova
Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover, TCR specificity of Tfr to self-antigens is not known. Our study suggests that nuclear proteins contain antigens specific to Tfr. Targeting of these proteins to antigen-specific B cells in mice triggers rapid accumulation of Tfr with immunosuppressive characteristics...
March 2, 2023: ELife
https://read.qxmd.com/read/36773051/hydroxyapatite-coated-compared-with-stainless-steel-external-fixation-pins-did-not-show-impact-in-the-rate-of-pin-track-infection-a-multicenter-prospective-study
#37
JOURNAL ARTICLE
Cristhopher Stoffel, Everton de Lima, Mauro José Salles
PURPOSE: Infection at the pin site remains the most common complication of external fixators (EFs). It is known that hydroxyapatite (HA)-coated pins increase bone adhesion and may lead to reduced rates of reported infections. The present study compares the rates of pin track infection associated with stainless steel and HA-coated pins. METHODS: This is a prospective, multicenter, nonrandomized, comparative intervention study among patients undergoing surgical treatment with EFs of any type between April 2018 and October 2021...
February 11, 2023: International Orthopaedics
https://read.qxmd.com/read/36748442/the-paradigm-of-the-inflammatory-radicular-cyst-biological-aspects-to-be-considered
#38
REVIEW
Nestor Rios Osorio, Javier Caviedes-Bucheli, Lorenzo Mosquera-Guevara, Juan Sebastian Adames-Martinez, Daison Gomez-Pinto, Karin Jimenez-Jimenez, Helida Avendano Maz, Sandra Bornacelly-Mendoza
Inflammatory radicular cysts (IRCs) are chronic lesions that follow the development of periapical granulomas (PGs). IRCs result from multiple inflammatory reactions led initially by several pro-inflammatory interleukins and growth factors that provoke the proliferation of epithelial cells derived from epithelial cell rests of Malassez present in the granulomatous tissue, followed by cyst formation and growth processes. Multiple theories have been proposed to help explain the molecular process involved in the development of the IRC from a PG...
January 2023: European Endodontic Journal
https://read.qxmd.com/read/36737428/glycolysis-related-lncrna-tmem105-upregulates-ldha-to-facilitate-breast-cancer-liver-metastasis-via-sponging-mir-1208
#39
JOURNAL ARTICLE
Jinzhu Han, Xuyi Chen, Jianlong Wang, Bin Liu
Increased glycolysis is one of the key metabolic hallmarks of cancer cells. However, the roles of lncRNAs in energy metabolism and cancer metastasis remain unclear. Here, the expression of TMEM105 associated with glycolysis was dramatically elevated from normal to breast cancer to breast cancer liver metastasis tissues, and the survival analysis revealed that high TMEM105 expression was related to poor survival, especially in patients with liver metastasis. Moreover, TMEM105 facilitated the glycolysis of breast cancer cells and induced cell invasion and breast cancer liver metastasis (BCLM)...
February 3, 2023: Cell Death & Disease
https://read.qxmd.com/read/36704840/the-hippo-pathway-regulates-photosensitivity-in-lupus-skin
#40
JOURNAL ARTICLE
Grace A Hile, Patrick Coit, Bin Xu, Amanda M Victory, Mehrnaz Gharaee-Kermani, Shannon N Estadt, Mitra P Maz, Jacob W S Martens, Rachael Wasikowski, Craig Dobry, Lam C Tsoi, Ramiro Iglesias-Bartolome, Celine C Berthier, Allison C Billi, Johann E Gudjonsson, Amr H Sawalha, J Michelle Kahlenberg
OBJECTIVE: Photosensitivity is one of the most common manifestations of systemic lupus erythematosus (SLE), yet its pathogenesis is not well understood. Normal-appearing epidermis of patients with SLE exhibits increased UVB-driven cell death that persists in cell culture. Here we investigate the role of epigenetic modification and Hippo signaling in enhanced UVB-induced apoptosis seen in SLE keratinocytes. METHODS: DNA methylation was analyzed using bisulfite sequencing from cultured SLE keratinocytes compared to healthy control (n=6, each)...
January 26, 2023: Arthritis & Rheumatology
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