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https://www.readbyqxmd.com/read/28330874/high-resolution-3d-nmr-structure-of-the-kras-proto-oncogene-promoter-reveals-key-features-of-a-g-quadruplex-involved-in-transcriptional-regulation
#1
Abdelaziz Kerkour, Julien Marquevielle, Stefaniia Ivashchenko, Liliya A Yatsunyk, Jean-Louis Mergny, Gilmar F Salgado
Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4). G4s can coexist with canonical duplex DNA in the human genome and have been suggested to suppress gene transcription, and much attention has therefore focused on studying G4s in promotor regions of disease-related genes. For example, the human KRAS proto-oncogene contains a nuclease-hypersensitive element (1) located upstream of the major transcription start site...
March 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28279832/anti-myc-associated-zinc-finger-protein-antibodies-are-associated-with-inflammatory-atherosclerotic-lesions-on-18-f-fluorodeoxyglucose-positron-emission-tomography
#2
Diana Ernst, Desiree Weiberg, Niklas T Baerlecken, Wolfgang Schlumberger, Cornelia Daehnrich, Reinhold E Schmidt, Frank M Bengel, Thorsten Derlin, Torsten Witte
BACKGROUND AND AIMS: Atherosclerosis is a chronic inflammatory process of vessel walls responsible for coronary, cerebrovascular and peripheral vascular disease, which together account for the majority of non-infective global deaths. Whilst great emphasis has been placed on lifestyle factors, a growing body of evidence supports an autoimmune component to atherosclerosis. This study evaluates a novel autoantibody against MYC-associated zinc finger protein (MAZ-Ab) as a potential marker of atherosclerosis...
April 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28205371/integrating-gut-microbiota-immaturity-and-disease-discriminatory-taxa-to-diagnose-the-initiation-and-severity-of-shrimp-disease
#3
Jinbo Xiong, Jinyong Zhu, Wenfang Dai, Chunming Dong, Qiongfen Qiu, Chenghua Li
Increasing evidence has emerged a tight link among the gut microbiota, host age and health status. This osculating interplay impedes the definition of gut microbiome features associated with host health from that in developmental stages. Consequently, gut microbiota-based prediction of health status is promising yet not well established. Here we firstly tracked shrimp gut microbiota (N = 118) over an entire cycle of culture; shrimp either stayed healthy or progressively transitioned into severe disease...
February 15, 2017: Environmental Microbiology
https://www.readbyqxmd.com/read/28153728/mir-34c-and-plncrna1-mediated-the-function-of-intestinal-epithelial-barrier-by-regulating-tight-junction-proteins-in-inflammatory-bowel-disease
#4
Tanzhou Chen, Haibo Xue, Ruoyang Lin, Zhiming Huang
BACKGROUND: Inflammatory bowel disease (IBD) is originated from uncontrolled inflammation, and desired methods for IBD therapy remains the main difficult. The network comprised with miRNA and lncRNA has been verified to play an important role on diverse human diseases. In this study, we demonstrated the role of miR-34c and lncRNA PlncRNA1 on the function of intestinal barrier. METHODS: Intestinal epithelial barrier model was constructed based on normal intestinal epithelial cell line Caco-2...
April 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28008270/overexpression-and-clinical-significance-of-myc-associated-zinc-finger-protein-in-pancreatic-carcinoma
#5
Xiaonian Zhu, Wei Luo, Wenjin Liang, Fen Tang, Chunhua Bei, Yuan Ren, Linyuan Qin, Chao Tan, Ying Zhang, Shengkui Tan
This study aimed to investigate the expression and clinical significance of MYC-associated zinc finger protein (MAZ) in pancreatic carcinoma (PC), and the biological functions of MAZ in PC cells. MAZ expression was detected in 57 PC tissues and 41 paired adjacent nontumor tissues by immunohistochemistry. Compared to the expression in adjacent nontumor tissues, MAZ was significantly higher expressed in PC tissues (P<0.0001). In addition, MAZ expression had a significant correlation with certain clinical characteristics of PC patients, such as age, tumor diameter, tumor number, and the serum level of CA199 (P<0...
2016: OncoTargets and Therapy
https://www.readbyqxmd.com/read/27973451/evaluation-of-laser-assisted-trans-nail-drug-delivery-with-optical-coherence-tomography
#6
Meng-Tsan Tsai, Ting-Yen Tsai, Su-Chin Shen, Chau Yee Ng, Ya-Ju Lee, Jiann-Der Lee, Chih-Hsun Yang
The nail provides a functional protection to the fingertips and surrounding tissue from external injuries. The nail plate consists of three layers including dorsal, intermediate, and ventral layers. The dorsal layer consists of compact, hard keratins, limiting topical drug delivery through the nail. In this study, we investigate the application of fractional CO₂ laser that produces arrays of microthermal ablation zones (MAZs) to facilitate drug delivery in the nails. We utilized optical coherence tomography (OCT) for real-time monitoring of the laser-skin tissue interaction, sparing the patient from an invasive surgical sampling procedure...
December 12, 2016: Sensors
https://www.readbyqxmd.com/read/27929127/lipid-modified-g4-decoy-oligonucleotide-anchored-to-nanoparticles-delivery-and-bioactivity-in-pancreatic-cancer-cells
#7
S Cogoi, U Jakobsen, E B Pedersen, S Vogel, L E Xodo
KRAS is mutated in >90% of pancreatic ductal adenocarcinomas. As its inactivation leads to tumour regression, mutant KRAS is considered an attractive target for anticancer drugs. In this study we report a new delivery strategy for a G4-decoy oligonucleotide that sequesters MAZ, a transcription factor essential for KRAS transcription. It is based on the use of palmitoyl-oleyl-phosphatidylcholine (POPC) liposomes functionalized with lipid-modified G4-decoy oligonucleotides and a lipid-modified cell penetrating TAT peptide...
December 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27919837/ex-vivo-itreg-differentiation-revisited-convenient-alternatives-to-existing-strategies
#8
Billur Akkaya, Amanda H Holstein, Christopher Isaac, Mitra P Maz, Deborah D Glass, Ethan M Shevach, Munir Akkaya
Ex-vivo differentiation of regulatory T cells (Tregs) from naïve CD4(+) T-cells has been widely used in immunological research. Isolation of a highly pure naïve T cell population is the key factor that determines the efficiency of subsequent Treg differentiation. Currently, this step relies mostly on FACS sorting, which is often costly, time consuming, and inconvenient. Alternatively, magnetic separation of T-cells can be performed; yet, available protocols fail to reach sort level purity and consequently result in low Treg differentiation efficiency...
February 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/27888145/critical-role-of-hnrnp-a1-in-activating-kras-transcription-in-pancreatic-cancer-cells-a-molecular-mechanism-involving-g4-dna
#9
REVIEW
Susanna Cogoi, Valentina Rapozzi, Sabina Cauci, Luigi E Xodo
KRAS is one of the most mutated genes in human cancer. Its crucial role in the tumourigenesis of pancreatic ductal adenocarcinoma (PDAC) has been widely demonstrated. As this deadly cancer does not sufficiently respond to conventional chemotherapies, it is important to increase our knowledge of pancreatic cancer biology, in particular how oncogenic KRAS is regulated. The promoter of KRAS contains a GA-element composed of runs of guanines that fold into a G4 structure. This unusual DNA conformation is recognized by several nuclear proteins, including MAZ and hnRNP A1...
November 22, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27861158/myc-associated-zinc-finger-protein-promotes-the-invasion-and-metastasis-of-hepatocellular-carcinoma-by-inducing-epithelial-mesenchymal-transition
#10
Wei Luo, Xiaonian Zhu, Wei Liu, Yuan Ren, Chunhua Bei, Linyuan Qin, Xueyan Miao, Fen Tang, Guifang Tang, Shengkui Tan
MYC associated zinc finger protein (MAZ) plays a key role in regulation of gene expression and tumor development. Studies have shown that deregulated expression of MAZ is closely related to the progression of tumors such as glioblastoma, breast cancer, prostate cancer and liposarcoma. However, the role of MAZ in hepatocellular carcinoma (HCC) has not been fully elucidated. Here, we found that expression of MAZ was increased in HCC and correlated to the distant metastasis of HCC. Moreover, we found that MAZ had a relationship with zinc finger E-box binding homeobox 1 and 2 (ZEB1 and ZEB2), two important mesenchymal markers in epithelial-mesenchymal transition (EMT) that were over-expressed in HCC...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/27835937/fractional-laser-assisted-topical-delivery-leads-to-enhanced-accelerated-and-deeper-cutaneous-5-fluorouracil-uptake
#11
Emily Wenande, Uffe H Olesen, Mette M B Nielsen, Christian Janfelt, Steen Honoré Hansen, R Rox Anderson, Merete Haedersdal
BACKGROUND: Topical 5-Fluorouracil (5-FU) exhibits suboptimal efficacy for non-melanoma skin cancer, attributed to insufficient intracutaneous penetration. This study investigates the impact of ablative fractional laser (AFXL) at different laser-channel depths on cutaneous 5-FU pharmacokinetics and biodistribution. METHODS: In vitro porcine skin underwent AFXL-exposure using a fractional 10,600 nm CO2-laser, generating microscopic ablation zones (MAZ) reaching the dermoepidermal junction (MAZ-ED), superficial-(MAZ-DS), or mid-dermis(MAZ-DM)...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27768596/elevated-expression-of-znf217-promotes-prostate-cancer-growth-by-restraining-ferroportin-conducted-iron-egress
#12
Xingkang Jiang, Changwen Zhang, Shiyong Qi, Shanqi Guo, Yue Chen, E Du, Hongtuan Zhang, Xiaoming Wang, Ranlu Liu, Baomin Qiao, Kuo Yang, Zhihong Zhang, Yong Xu
Although we and other studies indicated ZNF217 expression was increased in prostate cancer (PCa), the factors mediating its misregulated expression and their oncogenic activity remain largely unexplored. Recent evidence demonstrated that ferroportin (FPN) reduction lead to decreased iron export and increased intercellular iron that consequently aggravates the oncogenic effects of iron. In the present study, ZNF217 was identified as a transcriptional repressor that inhibits FPN expression. Increased of ZNF217 expression led to decreased FPN concentration, coupled with resultant intracellular iron retention, increased iron-related cellular activities and enhanced tumor cell growth...
October 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27632283/iranian-johnsongrass-mosaic-virus-the-complete-genome-sequence-molecular-and-biological-characterization-and-comparison-of-coat-protein-gene-sequences
#13
Zohreh Moradi, Mohsen Mehrvar, Ehsan Nazifi, Mohammad Zakiaghl
Iranian johnsongrass mosaic virus (IJMV) is one of the most prevalent viruses causing maize mosaic disease in Iran. An IJMV isolate, Maz-Bah, was obtained from the maize showing mosaic symptoms in Mazandaran, north of Iran. The complete genomic sequence of Maz-Bah is 9544 nucleotides, excluding the poly(A) tail. It contains one single open reading frame of 9165 nucleotides and encodes a large polyprotein of 3054 amino acids, flanked by a 5'-untranslated region (UTR) of 143 nucleotides and a 3'-UTR of 236 nucleotides...
February 2017: Virus Genes
https://www.readbyqxmd.com/read/27534615/gene-signatures-associated-with-adaptive-humoral-immunity-following-seasonal-influenza-a-h1n1-vaccination
#14
I G Ovsyannikova, H M Salk, R B Kennedy, I H Haralambieva, M T Zimmermann, D E Grill, A L Oberg, G A Poland
This study aimed to identify gene expression markers shared between both influenza hemagglutination inhibition (HAI) and virus-neutralization antibody (VNA) responses. We enrolled 158 older subjects who received the 2010-2011 trivalent inactivated influenza vaccine. Influenza-specific HAI and VNA titers and mRNA-sequencing were performed using blood samples obtained at Days 0, 3 and 28 post vaccination. For antibody response at Day 28 versus Day 0, several gene sets were identified as significant in predictive models for HAI (n=7) and VNA (n=35) responses...
December 2016: Genes and Immunity
https://www.readbyqxmd.com/read/27391153/carboxyl-terminal-truncated-hbx-contributes-to-invasion-and-metastasis-via-deregulating-metastasis-suppressors-in-hepatocellular-carcinoma
#15
Weihua Li, Man Li, Dongjiang Liao, Xinpeng Lu, Xia Gu, Qianqian Zhang, Zhixiang Zhang, Hui Li
Hepatitis B virus (HBV) X protein (HBx), a trans-regulator, is frequently expressed in truncated form without carboxyl-terminus in hepatocellular carcinoma (HCC), but its functional mechanisms are not fully defined. In this report, we investigated frequency of this natural HBx mutant in HCCs and its functional significance. In 102 HBV-infected patients with HCC, C-terminal truncation of HBx, in contrast to full-length HBx, were more prevalent in tumors (70.6%) rather than adjacent non-tumorous tissues (29.4%) (p = 0...
August 23, 2016: Oncotarget
https://www.readbyqxmd.com/read/27386562/novel-multiple-sclerosis-susceptibility-loci-implicated-in-epigenetic-regulation
#16
Till F M Andlauer, Dorothea Buck, Gisela Antony, Antonios Bayas, Lukas Bechmann, Achim Berthele, Andrew Chan, Christiane Gasperi, Ralf Gold, Christiane Graetz, Jürgen Haas, Michael Hecker, Carmen Infante-Duarte, Matthias Knop, Tania Kümpfel, Volker Limmroth, Ralf A Linker, Verena Loleit, Felix Luessi, Sven G Meuth, Mark Mühlau, Sandra Nischwitz, Friedemann Paul, Michael Pütz, Tobias Ruck, Anke Salmen, Martin Stangel, Jan-Patrick Stellmann, Klarissa H Stürner, Björn Tackenberg, Florian Then Bergh, Hayrettin Tumani, Clemens Warnke, Frank Weber, Heinz Wiendl, Brigitte Wildemann, Uwe K Zettl, Ulf Ziemann, Frauke Zipp, Janine Arloth, Peter Weber, Milena Radivojkov-Blagojevic, Markus O Scheinhardt, Theresa Dankowski, Thomas Bettecken, Peter Lichtner, Darina Czamara, Tania Carrillo-Roa, Elisabeth B Binder, Klaus Berger, Lars Bertram, Andre Franke, Christian Gieger, Stefan Herms, Georg Homuth, Marcus Ising, Karl-Heinz Jöckel, Tim Kacprowski, Stefan Kloiber, Matthias Laudes, Wolfgang Lieb, Christina M Lill, Susanne Lucae, Thomas Meitinger, Susanne Moebus, Martina Müller-Nurasyid, Markus M Nöthen, Astrid Petersmann, Rajesh Rawal, Ulf Schminke, Konstantin Strauch, Henry Völzke, Melanie Waldenberger, Jürgen Wellmann, Eleonora Porcu, Antonella Mulas, Maristella Pitzalis, Carlo Sidore, Ilenia Zara, Francesco Cucca, Magdalena Zoledziewska, Andreas Ziegler, Bernhard Hemmer, Bertram Müller-Myhsok
We conducted a genome-wide association study (GWAS) on multiple sclerosis (MS) susceptibility in German cohorts with 4888 cases and 10,395 controls. In addition to associations within the major histocompatibility complex (MHC) region, 15 non-MHC loci reached genome-wide significance. Four of these loci are novel MS susceptibility loci. They map to the genes L3MBTL3, MAZ, ERG, and SHMT1. The lead variant at SHMT1 was replicated in an independent Sardinian cohort. Products of the genes L3MBTL3, MAZ, and ERG play important roles in immune cell regulation...
June 2016: Science Advances
https://www.readbyqxmd.com/read/27264947/laser-assisted-delivery-of-topical-methotrexate-in-vitro-investigations
#17
REVIEW
Elisabeth Hjardem Taudorf
Ablative fractional lasers (AFXL) are increasingly used to treat dermatological disorders and to facilitate laser-assisted topical drug delivery. In this thesis, laser-tissue interactions generated by stacked pulses with a miniaturized low-power 2,940 nm AFXL were characterized (study I). Knowledge of the correlation between laser parameters and tissue effects was used to deliver methotrexate (MTX) topically through microscopic ablation zones (MAZs) of precise dimensions. MTX is a well-known chemotherapeutic and anti-inflammatory drug that may cause systemic adverse effects, and topical delivery is thus of potential benefit...
June 2016: Danish Medical Journal
https://www.readbyqxmd.com/read/27194098/stakeholders-views-on-granting-prescribing-authority-to-pharmacists-in-nigeria-a-qualitative-study
#18
Asa Auta, Barry Strickland-Hodge, Julia Maz
Background In Nigeria, only medical doctors, dentists and some nurses in primary care facilities have the legal right to prescribe medicines to patients. Patients' access to prescription medicines can be seriously affected by the shortage of prescribers leading to longer waiting times in hospitals. Objective This research was carried out to investigate stakeholders' views on granting prescribing authority to pharmacists in Nigeria. Setting The study was conducted in Nigeria. Methods Qualitative, semi-structured interviews were conducted with 43 Nigerian stakeholders including policymakers, pharmacists, doctors and patient group representatives...
August 2016: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27023055/corrigendum-maz-mediates-the-cross-talk-between-ct-1-and-notch1-signaling-during-gliogenesis
#19
Bin Liu, Anyun Ma, Feng Zhang, Yumeng Wang, Zengmin Li, Qingyu Li, Zhiheng Xu, Yufang Zheng
No abstract text is available yet for this article.
March 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/26969559/challenges-to-clinical-pharmacy-practice-in-nigerian-hospitals-a-qualitative-exploration-of-stakeholders-views
#20
Asa Auta, Barry Strickland-Hodge, Julia Maz
RATIONALE, AIMS AND OBJECTIVES: In Nigeria, a shift from the traditional pharmacists' role of dispensing and compounding of medications began in the 1980s with the introduction of drug information services and unit dose-dispensing systems in some hospitals. More than three decades after this, clinical pharmacy practice is still underdeveloped. This study was conducted to explore stakeholders' views on the barriers to the development of clinical pharmacy practice in Nigerian hospitals...
October 2016: Journal of Evaluation in Clinical Practice
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