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https://www.readbyqxmd.com/read/29764244/kinetics-and-tissue-repair-process-following-fractional-bipolar-radiofrequency-treatment
#1
G Kokolakis, L von Eichel, M Ulrich, J Lademann, T Zuberbier, M A Hofmann
INTRODUCTION: Fractionated radiofrequency (RF) tissue tightening is an alternative method to fractionated laser treatment of skin wrinkling, laxity and acne scars, with reduced risk of scarring or persistent pigmentation. The aim of this study was to evaluate and quantify the wound healing process after RF treatment. MATERIALS AND METHODS: 12 patients were treated with a 64-pin fractional bipolar RF device with 60 mJ/pin applied energy. Confocal laser scanning microscopy (CLSM) examination was performed on day 1, day 2, day 7 and day 14 after treatment...
May 15, 2018: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/29694699/biosynthesis-and-heterologous-production-of-vioprolides-rational-biosynthetic-engineering-and-unprecedented-4-methylazetidinecarboxylic-acid-formation
#2
Fu Yan, David Auerbach, Yi Chai, Lena Keller, Qiang Tu, Stephan Hüttel, Amelie Glemser, Hanusch A Grab, Thorsten Bach, Youming Zhang, Rolf Müller
Vioprolides are a promising class of anticancer and antifungal lead compounds produced by the myxobacterium Cystobacter violaceus Cb vi35. So far, nothing is known about their biosynthesis, including the origin of the unusual 4 methylazetidinecarboxylic acid (MAZ) moiety. We describe the vioprolide biosynthetic gene cluster and solve the production obstacle by expression in three heterologous hosts. Starting from unstable production in the wild type at single digit mg/L scale, we developed a stable host that eventually allowed for yields up to half a gram per liter in fermenters...
April 25, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29532803/development-maz-mediates-urogenital-development
#3
Louise Stone
No abstract text is available yet for this article.
March 13, 2018: Nature Reviews. Urology
https://www.readbyqxmd.com/read/29432158/16p11-2-transcription-factor-maz-is-a-dosage-sensitive-regulator-of-genitourinary-development
#4
Meade Haller, Jason Au, Marisol O'Neill, Dolores J Lamb
Genitourinary (GU) birth defects are among the most common yet least studied congenital malformations. Congenital anomalies of the kidney and urinary tract (CAKUTs) have high morbidity and mortality rates and account for ∼30% of structural birth defects. Copy number variation (CNV) mapping revealed that 16p11.2 is a hotspot for GU development. The only gene covered collectively by all of the mapped GU-patient CNVs was MYC-associated zinc finger transcription factor ( MAZ ), and MAZ CNV frequency is enriched in nonsyndromic GU-abnormal patients...
February 20, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29414775/the-maz-transcription-factor-is-a-downstream-target-of-the-oncoprotein-cyr61-ccn1-and-promotes-pancreatic-cancer-cell-invasion-via-craf-erk-signaling
#5
Gargi Maity, Inamul Haque, Arnab Ghosh, Gopal Dhar, Vijayalaxmi Gupta, Sandipto Sarkar, Imaan Azeem, Douglas McGregor, Abhishek Choudhary, Donald R Campbell, Suman Kambhampati, Sushanta K Banerjee, Snigdha Banerjee
Myc-associated zinc-finger protein (MAZ) is a transcription factor with dual roles in transcription initiation and termination. Deregulation of MAZ expression is associated with the progression of pancreatic ductal adenocarcinoma (PDAC). However, the mechanism of action of MAZ in PDAC progression is largely unknown. Here, we present evidence that MAZ mRNA expression and protein levels are increased in human PDAC cell lines, tissue samples, a subcutaneous tumor xenograft in a nude mouse model, and spontaneous cancer in the genetically engineered PDAC mouse model...
March 23, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29382233/an-in-vivo-study-of-hypericum-perforatum-in-a-niosomal-topical-drug-delivery-system
#6
Mohamed Ali, Amira Abdel Motaal, Mohammed A Ahmed, Abdulrhman Alsayari, Omaima N El-Gazayerly
The active compounds present in Hypericum perforatum L. (Hypericaceae) include hyperforin, hypericins and flavonoids, which are assumed to be responsible for the activity of the extract in the treatment of wounds and scars. The present study aimed to incorporate H. perforatum extract standardized to a known content of phloroglucinols, naphthodianthrones and polyphenolic compounds into an effective transdermal drug delivery system capable of entrapping both lipophilic and hydrophilic constituents in the form of niosomal gels for wound treatment...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29348878/identification-of-cancer-prognosis-associated-functional-modules-using-differential-co-expression-networks
#7
Wenshuai Yu, Shengjie Zhao, Yongcui Wang, Brian Nlong Zhao, Weiling Zhao, Xiaobo Zhou
The rapid accumulation of cancer-related data owing to high-throughput technologies has provided unprecedented choices to understand the progression of cancer and discover functional networks in multiple cancers. Establishment of co-expression networks will help us to discover the systemic properties of carcinogenesis features and regulatory mechanisms of multiple cancers. Here, we proposed a computational workflow to identify differentially co-expressed gene modules across 8 cancer types by using combined gene differential expression analysis methods and a higher-order generalized singular value decomposition...
December 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29340471/epididymo-orchitis-caused-by-histoplasma-capsulatumin-a-colombian-patient
#8
Carlos Andrés Botero-García, Álvaro Adolfo Faccini-Martínez, Erika Uribe, Omar-Javier Calixto, Carlos Eduardo Pérez-Díaz, Pedro Pablo Osejo-Diago, Pedro Gabriel Franco-Maz
Although histoplasmosis is generally a self-limited disease, disseminated infection can occur in patients lacking effective cell-mediated immunity, reaching virtually every organ, even the genitourinary tract in rare cases. We report a case of epididymo-orchitis in an immunocompetent 38-year-old bricklayer from the rural area of Villeta, Cundinamarca, Colombia. The patient presented with testicular pain and macroscopic scrotal changes requiring a left orchiectomy, with microbiological isolation and molecular confirmation of Histoplasma capsulatum...
November 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29209328/antibodies-against-myc-associated-zinc-finger-protein-an-independent-marker-in-acute-coronary-syndrome
#9
Diana Ernst, Christian Widera, Niklas T Baerlecken, Wolfgang Schlumberger, Cornelia Daehnrich, Reinhold E Schmidt, Katja Gabrysch, Lars Wallentin, Torsten Witte
Introduction: Atherosclerosis is considered the pathophysiology underlying cardiovascular (CVD), cerebrovascular, and peripheral vascular diseases. Evidence supporting an autoimmune component is emerging, with imaging studies correlating MYC-associated zinc finger protein antibody (MAZ-Ab) optical density (OD) with plaque activity. This study compares MAZ-Ab OD on ELISA testing among patients presenting with acute coronary syndromes (ACSs) to healthy controls and investigates the association of MAZ-Ab to traditional CVD risk factors...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29193173/the-fractional-laser-induced-coagulation-zone-characterized-over-time-by-laser-scanning-confocal-microscopy-a-proof-of-concept-study
#10
Christina A Banzhaf, Lynlee L Lin, Nhung Dang, Michael Freeman, Merete Haedersdal, Tarl W Prow
BACKGROUND: Ablative fractional laser (AFXL) is an acknowledged technique to increase uptake of topical agents in skin. Micro thermal ablation zones (MAZs) consist of ablated vertical channels surrounded by a coagulation zone (CZ). Laser scanning confocal microscopy (LSCM) images individual MAZs at 733 nm (reflectance confocal microscopy (RCM)). Further, LSCM can image sodium fluorescein (NaF) fluorescence with 488 nm excitation (fluorescence confocal microcopy (FCM)), a small hydrophilic test molecule (370 MW, log P -1...
January 2018: Lasers in Surgery and Medicine
https://www.readbyqxmd.com/read/29165690/the-regulatory-g4-motif-of-the-kirsten-ras-kras-gene-is-sensitive-to-guanine-oxidation-implications-on-transcription
#11
Susanna Cogoi, Annalisa Ferino, Giulia Miglietta, Erik B Pedersen, Luigi E Xodo
KRAS is one of the most mutated genes in human cancer. It is controlled by a G4 motif located upstream of the transcription start site. In this paper, we demonstrate that 8-oxoguanine (8-oxoG), being more abundant in G4 than in non-G4 regions, is a new player in the regulation of this oncogene. We designed oligonucleotides mimicking the KRAS G4-motif and found that 8-oxoG impacts folding and stability of the G-quadruplex. Dimethylsulphate-footprinting showed that the G-run carrying 8-oxoG is excluded from the G-tetrads and replaced by a redundant G-run in the KRAS G4-motif...
January 25, 2018: Nucleic Acids Research
https://www.readbyqxmd.com/read/29040049/recent-trends-in-common-chemical-feed-and-food-contaminants-in-israel
#12
REVIEW
J A Shimshoni, S Barel
In February 2014 a new law was approved by the Israeli parliament, namely the Control of Animal Feed Law. The law intends to regulate the production and marketing of animal feed. In preparation for the law's implementation in 2017, we have assessed the current feed and food safety challenges in Israel in recent years in association with the presence of common undesirable contaminants in various common feed and food commodities. Tight collaboration between regulatory authorities and feed/food industry, enhanced feed and food quality monitoring, transparency of survey results and readily accessible and reliable information for the public about health hazards of chemical contaminants, will guarantee the safety and quality of food and feed...
October 2, 2017: Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews
https://www.readbyqxmd.com/read/28973440/maz-induces-myb-expression-during-the-exit-from-quiescence-via-the-e2f-site-in-the-myb-promoter
#13
Josué Álvaro-Blanco, Katia Urso, Yuri Chiodo, Carla Martín-Cortázar, Omar Kourani, Pablo Gómez-Del Arco, María Rodríguez-Martínez, Esther Calonge, José Alcamí, Juan Miguel Redondo, Teresa Iglesias, Miguel R Campanero
Most E2F-binding sites repress transcription through the recruitment of Retinoblastoma (RB) family members until the end of the G1 cell-cycle phase. Although the MYB promoter contains an E2F-binding site, its transcription is activated shortly after the exit from quiescence, before RB family members inactivation, by unknown mechanisms. We had previously uncovered a nuclear factor distinct from E2F, Myb-sp, whose DNA-binding site overlapped the E2F element and had hypothesized that this factor might overcome the transcriptional repression of MYB by E2F-RB family members...
September 29, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28878769/protective-role-of-mast-cells-in-primary-systemic-vasculitis-a-perspective
#14
Jason M Springer, Vineesh V Raveendran, Selina A Gierer, Mehrdad Maz, Kottarappat N Dileepan
Mast cells are important cells of the immune system. Although traditionally considered as key players in allergic and hypersensitivity reactions, emerging evidence suggests that mast cells have many complex roles in vascular disease. These include regulation of vasodilation, angiogenesis, activation of matrix metalloproteinases, apoptosis of smooth muscle cells, and activation of the renin angiotensin system. Mast cells are also known to play an immunomodulatory role via modulation of regulatory T-cell (Treg), macrophage and endothelial cell functions...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28878619/mirna-enriched-in-human-neuroblast-nuclei-bind-the-maz-transcription-factor-and-their-precursors-contain-the-maz-consensus-motif
#15
Belinda J Goldie, Chantel Fitzsimmons, Judith Weidenhofer, Joshua R Atkins, Dan O Wang, Murray J Cairns
While the cytoplasmic function of microRNA (miRNA) as post-transcriptional regulators of mRNA has been the subject of significant research effort, their activity in the nucleus is less well characterized. Here we use a human neuronal cell model to show that some mature miRNA are preferentially enriched in the nucleus. These molecules were predominantly primate-specific and contained a sequence motif with homology to the consensus MAZ transcription factor binding element. Precursor miRNA containing this motif were shown to have affinity for MAZ protein in nuclear extract...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28577976/dual-function-of-maz-mediated-by-foxf2-in-basal-like-breast-cancer-promotion-of-proliferation-and-suppression-of-progression
#16
Zi-Han Yu, Shu-Min Lun, Rui He, Hong-Pan Tian, Huan-Jing Huang, Qing-Shan Wang, Xiao-Qing Li, Yu-Mei Feng
Myc-associated zinc finger protein (MAZ) is a transcription factor with C2H2-type zinc-finger motifs that can bind GC-rich cis-elements. MAZ activates the transcription of some cancer-related genes and represses that of others, suggesting that changes in MAZ expression may play different roles in the development and progression of different types or subtypes of cancers depending on its target genes. However, the functions and mechanisms of MAZ in regulating the carcinogenesis and progression of breast cancer have remained unclear...
August 28, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28497878/pharmacist-prescribing-a-cross-sectional-survey-of-the-views-of-pharmacists-in-nigeria
#17
Asa Auta, Barry Strickland-Hodge, Julia Maz, Shalkur David
OBJECTIVES: This study was carried out to: (1) explore the views of pharmacists in Nigeria on the extension of prescribing authority to them and determine their willingness to be prescribers and (2) identify the potential facilitators and barriers to introducing pharmacist prescribing in Nigeria. METHOD: An online cross-sectional survey was conducted from August to October 2014 among 775 pharmacists recruited from the Facebook group of the Pharmaceutical Society of Nigeria using a simple random technique...
May 12, 2017: International Journal of Pharmacy Practice
https://www.readbyqxmd.com/read/28330874/high-resolution-three-dimensional-nmr-structure-of-the-kras-proto-oncogene-promoter-reveals-key-features-of-a-g-quadruplex-involved-in-transcriptional-regulation
#18
Abdelaziz Kerkour, Julien Marquevielle, Stefaniia Ivashchenko, Liliya A Yatsunyk, Jean-Louis Mergny, Gilmar F Salgado
Non-canonical base pairing within guanine-rich DNA and RNA sequences can produce G-quartets, whose stacking leads to the formation of a G-quadruplex (G4). G4s can coexist with canonical duplex DNA in the human genome and have been suggested to suppress gene transcription, and much attention has therefore focused on studying G4s in promotor regions of disease-related genes. For example, the human KRAS proto-oncogene contains a nuclease-hypersensitive element located upstream of the major transcription start site...
May 12, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28279832/anti-myc-associated-zinc-finger-protein-antibodies-are-associated-with-inflammatory-atherosclerotic-lesions-on-18-f-fluorodeoxyglucose-positron-emission-tomography
#19
COMPARATIVE STUDY
Diana Ernst, Desiree Weiberg, Niklas T Baerlecken, Wolfgang Schlumberger, Cornelia Daehnrich, Reinhold E Schmidt, Frank M Bengel, Thorsten Derlin, Torsten Witte
BACKGROUND AND AIMS: Atherosclerosis is a chronic inflammatory process of vessel walls responsible for coronary, cerebrovascular and peripheral vascular disease, which together account for the majority of non-infective global deaths. Whilst great emphasis has been placed on lifestyle factors, a growing body of evidence supports an autoimmune component to atherosclerosis. This study evaluates a novel autoantibody against MYC-associated zinc finger protein (MAZ-Ab) as a potential marker of atherosclerosis...
April 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28205371/integrating-gut-microbiota-immaturity-and-disease-discriminatory-taxa-to-diagnose-the-initiation-and-severity-of-shrimp-disease
#20
Jinbo Xiong, Jinyong Zhu, Wenfang Dai, Chunming Dong, Qiongfen Qiu, Chenghua Li
Increasing evidence has emerged a tight link among the gut microbiota, host age and health status. This osculating interplay impedes the definition of gut microbiome features associated with host health from that in developmental stages. Consequently, gut microbiota-based prediction of health status is promising yet not well established. Here we firstly tracked shrimp gut microbiota (N = 118) over an entire cycle of culture; shrimp either stayed healthy or progressively transitioned into severe disease...
April 2017: Environmental Microbiology
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