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https://www.readbyqxmd.com/read/29227586/identification-of-potential-crucial-genes-associated-with-carcinogenesis-of-clear-cell-renal-cell-carcinoma
#1
Erlin Song, Wenting Song, Minghua Ren, Li Xing, Wenjun Ni, Yongxiang Li, Mancheng Gong, Mingbo Zhao, Xin Ma, Xu Zhang, Ruihua An
Clear cell renal cell carcinoma (ccRCC) is a common genitourinary malignancy with high mortality. However, the molecular pathogenesis of ccRCC remains unclear and effective biomarkers for daily practice are still limited. Thus, we aimed to identify the potential crucial genes and pathways associated with carcinogenesis of ccRCC and further analyze the molecular mechanisms implicated in tumorigenesis. In the present study, expression profiles GSE 66270, GSE 53757, GSE 36895 and GSE 76351 were downloaded from GEO database, including 244 matched primary and adjacent normal tissues, furthermore, the level 3 RNAseq dataset (RNAseqV2 RSEM) of KIRC was also downloaded from The Cancer Genome Atlas (TCGA), which consist of 529 ccRCC tumors and 72 normal tissues...
December 11, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29227266/prevalence-of-diseases-among-adolescent-population-in-dnepropetrovsk-region-ukraine-correlated-with-drinking-water-quality-deterioration
#2
L Hryhorenko, S Shchudro, A Shevchenko, N Rublevska, V Zaitsev
Purpose of research was to study dynamics prevalence of diseases among children' population in the separate rural tacsons of Dnepropetrovsk region; to carry out correlation analysis between some indicators of drinking water quality and prevalence of diseases. Research indicators of prevalence of diseases was carried out in the 6 types of tacsons of Dnipropetrovsk region (Ukraine) during 2008 - 2013 years (totally 522720 indicators). It was proved that (I, II, III, XI, XIII, XIV) classes of diseases takes the first place by the prevalence of diseases in the majority of rural tacsons...
November 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29225778/zika-virus-reservoirs-implications-for-transmission-future-outbreaks-drug-and-vaccine-development
#3
REVIEW
Raj Kalkeri, Krishna K Murthy
Zika virus (ZIKV) was recently declared as a 'Global Health Emergency' by the World Health Organization. Various tissue reservoirs of ZIKV in infected humans and animals models have been observed, the implications of which are not known. Compared to other Flaviviruses, sexual transmission and persistence in the genitourinary tract seem to be unique to ZIKV. ZIKV persistence and shedding in bodily secretions (e.g. saliva, semen) is a concern for potential disease spread and could pose challenges in diagnosis, regulatory guidelines and drug/vaccine development...
2017: F1000Research
https://www.readbyqxmd.com/read/29225693/cytoreductive-prostate-radiotherapy-in-oligometastatic-prostate-cancer-a-single-centre-analysis-of-toxicity-and-clinical-outcome
#4
Giulia Riva, Giulia Marvaso, Matteo Augugliaro, Dario Zerini, Cristiana Fodor, Gennaro Musi, Ottavio De Cobelli, Roberto Orecchia, Barbara Alicja Jereczek-Fossa
Objectives: The current standard of care for patients with metastatic prostate cancer (mPCa) at diagnosis is androgen deprivation therapy (ADT) with or without anti-androgen and chemotherapy. The aim of this study was to define the role of a local radiotherapy (RT) treatment in the mPCa setting. Methods: We retrospectively reviewed data of patients with PCa and bone oligometastases at diagnosis treated in our institution with ADT followed by cytoreductive prostate-RT with or without RT on metastases...
2017: Ecancermedicalscience
https://www.readbyqxmd.com/read/29224900/single-fraction-stereotactic-ablative-body-radiotherapy-for-oligometastasis-outcomes-from-132-consecutive-patients
#5
S Gandhidasan, D Ball, T Kron, M Bressel, M Shaw, J Chu, S Chander, G Wheeler, N Plumridge, B Chesson, S David, S Siva
AIMS: Stereotactic ablative body radiotherapy (SABR) is currently used to treat oligometastases, but the optimum dose/fractionation schedule is unknown. In this study, we evaluated outcomes after single fraction SABR in patients with oligometastatic disease. MATERIALS AND METHODS: Single institutional retrospective review of patients treated with single fraction SABR for one to three oligometastases between 2010 and 2015. The primary outcome was freedom from widespread disease defined as distant recurrence not amenable to surgery or SABR; or recurrence with four or more metastases...
December 7, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/29223545/the-bowel-function-and-quality-of-life-of-hirschsprung-disease-patients-who-have-reached-18-years-of-age-or-older-the-long-term-outcomes-after-undergoing-the-transabdominal-soave-procedure
#6
Shun Onishi, Kazuhiko Nakame, Tatsuru Kaji, Masato Kawano, Tomoe Moriguchi, Koshiro Sugita, Keisuke Yano, Mioko Nomura, Koji Yamada, Waka Yamada, Ryuta Masuya, Takafumi Kawano, Seiro Machigashira, Motoi Mukai, Satoshi Ieiri
BACKGROUND/PURPOSE: Hirschsprung disease (HD) is considered curable, but the postoperative bowel function is not always satisfactory. In this study, we evaluated the general condition, bowel function, and social performance in adults who were older than 17years of age who had undergone definitive operations in childhood. METHOD: From 1984 to 2016, 110 patients with HD underwent definitive surgery at our institute. Sixty-three patients who had undergone the transabdominal Soave procedure reached 18years of age...
December 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29221876/conventional-versus-hypofractionated-radiation-therapy-for-localized-prostate-cancer-a-meta-analysis-of-randomized-noninferiority-trials
#7
REVIEW
Trevor Joseph Royce, Dong Hoon Lee, NaNa Keum, Nitipong Permpalung, Calvin J Chiew, Sherise Epstein, Kristen M Pluchino, Anthony V D'Amico
CONTEXT: Whether hypofractionated radiation therapy (RT) compared with conventionally fractionated RT provides comparable or possibly improved cancer control without increased toxicity in localized prostate cancer (PC) remains unknown. OBJECTIVE: Realizing from the CHHiP trial that outcomes are highly sensitive to the dose fractionation schedule and number of treatments, we conducted a systematic review and meta-analysis selecting only the randomized noninferiority trials, because the randomized arms closely approximated one another in terms of the dose fractionation schedule, and compared cancer control and toxicity of hypofractionated RT with conventionally fractionated RT for localized PC...
November 4, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29220632/immunohistochemical-localization-of-fibrinogen-c-domain-containing-1-on-epithelial-and-mucosal-surfaces-in-human-tissues
#8
Sebastian von Huth, Jesper B Moeller, Anders Schlosser, Niels Marcussen, Ole Nielsen, Vicki Nielsen, Grith L Sorensen, Uffe Holmskov
Fibrinogen C domain containing 1 (FIBCD1) is a transmembrane receptor that binds chitin and other acetylated compounds with high affinity. FIBCD1 has previously been shown to be present in the epithelium of the gastrointestinal tract. In the present study, we performed a detailed analysis of normally structured human tissues for the expression of FIBCD1 by quantitative PCR and immunohistochemistry. We find that FIBCD1 is expressed in epithelial cells derived from all three germ layers. Endodermal-derived epithelial cells throughout the gastrointestinal tract and the respiratory system showed high expression of FIBCD1 and also mesodermal-derived cells in the genitourinary system and ectodermal-derived epidermis and sebaceous glands cells expressed FIBCD1...
December 1, 2017: Journal of Histochemistry and Cytochemistry: Official Journal of the Histochemistry Society
https://www.readbyqxmd.com/read/29212082/risk-factors-for-chemotherapy-related-toxicity-and-adverse-events-in-elderly-thai-cancer-patients-a-prospective-study
#9
Ekkamol Phaibulvatanapong, Varalak Srinonprasert, Suthinee Ithimakin
OBJECTIVES: To assess factors predisposing to severe chemotherapy-related toxicity and adverse events (AEs) and dose modification in aging cancer patients. METHODS: Cancer patients aged ≥70 years scheduled to receive the first cycle of a new chemotherapy regimen were enrolled. On the day of starting chemotherapy, demographic data, performance status (PS), and geriatric parameters were recorded. AEs and chemotherapy modification were recorded. Quality of life (QOL) was assessed at baseline and 3 months after starting chemotherapy or at the end of chemotherapy...
December 7, 2017: Oncology
https://www.readbyqxmd.com/read/29206774/associations-between-improvement-in-genitourinary-symptoms-of-menopause-and-changes-in-the-vaginal-ecosystem
#10
Caroline M Mitchell, Sujatha Srinivasan, Anna Plantinga, Michael C Wu, Susan D Reed, Katherine A Guthrie, Andrea Z LaCroix, Tina Fiedler, Matthew Munch, Congzhou Liu, Noah G Hoffman, Ian A Blair, Katherine Newton, Ellen W Freeman, Hadine Joffe, Lee Cohen, David N Fredricks
OBJECTIVE: The aim of the study was to identify associations between improvement in genitourinary symptoms of menopause (GSM) and vaginal microbiota, vaginal glycogen, and serum estrogen. METHODS: Thirty postmenopausal women enrolled in a hot flash treatment trial (oral estradiol vs venlafaxine vs placebo) who reported GSM and provided vaginal swabs at 0, 4, and 8 weeks were studied. Bacterial communities were characterized using deep sequencing targeting the 16S rRNA gene V3-V4 region...
December 4, 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29204527/outcomes-and-toxicity-of-313-prostate-cancer-patients-receiving-helical-tomotherapy-after-radical-prostatectomy
#11
Lindsay Jensen, Bertram Yuh, Jeffrey Y C Wong, Timothy Schultheiss, Jonathan Cheng, Nora Ruel, Przemyslaw Twardowski, Sagus Sampath
Purpose: There are limited long-term data on patients treated with image guided intensity modulated radiation therapy (IG-IMRT) for prostate cancer recurrence or high-risk disease features after radical prostatectomy. We report single-institution results for patients treated with IG-IMRT and identify variables associated with outcome. Methods and materials: This is a retrospective chart review consisting of 313 consecutive patients who were treated with adjuvant or salvage IG-IMRT from 2004 to 2013...
October 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/29204452/recurrent-lactobacillus-bacteremia-in-a-patient-with-leukemia
#12
Paurush Ambesh, Sarah Stroud, Eva Franzova, Joseph Gotesman, Kavita Sharma, Lawrence Wolf, Stephan Kamholz
Lactobacillus species are a commensal flora of the human gastrointestinal and the female genitourinary tract. Lactobacilli especially the rhamnosus species, are common components of commercial probiotics. They are rarely associated with pathology in immunocompetent people, but they have been known to cause dental caries, bacteremia, and endocarditis in patients with suppressed immune function. Cases of Lactobacillus bacteremia have been reported in patients with acute myeloid leukemia, large granular lymphocytic leukemia, and in transplant recipients...
October 2017: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/29204106/morbidity-dynamics-in-proton-photon-or-photon-radiation-therapy-for-locally-advanced-prostate-cancer
#13
Evgeny V Khmelevsky, Irina N Kancheli, Vladimir S Khoroshkov, Andrey D Kaprin
Aim: This study evaluated the frequency and long-term dynamics of early and late post irradiation damage after proton-photon or photon therapy for locally advanced prostate cancer. Background: The results of a randomized study of proton-photon or photon therapy using several fractionation regimes were analyzed in 272 patients with high and intermediate risk of progression. Materials and methods: Three variants of proton boost fractionation were studied sequentially: 3...
January 2018: Reports of Practical Oncology and Radiotherapy
https://www.readbyqxmd.com/read/29203997/perianal-paget-s-disease-a-case-report-and-a-review-of-current-diagnosis-and-management
#14
Chintamani Godbole, Jyoti Mehta, Bijoy Methil, Reshma Palep, Prajesh Bhuta
Paget's disease is an intraepithelial adenocarcinoma arising from the apocrine gland component of the skin. Paget's disease is most common in the breast but extra mammary disease is also seen. Perianal Paget's disease is a rare form of extramammary disease with few cases reported in literature. It can be primary-arising from the skin or secondary-cutaneous metastases of anorectal or genitourinary malignancy. We hereby wish to report a case of perianal Paget's disease that presented as an eczematous lesion and was diagnosed incidentally on biopsy...
December 2017: Indian Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29203185/conservative-management-of-high-grade-renal-trauma-does-not-lead-to-prolonged-hospital-stay
#15
Lindsay A Hampson, Kushan D Radadia, Anobel Y Odisho, Jack W McAninch, Benjamin N Breyer
Objective To evaluate the effect of conservative management of high-grade renal trauma on length of hospitalization, we aim to describe characteristics of patients with high-grade renal trauma that are associated with an increased length of stay (LOS) and the effect of conservative versus surgical management on hospital LOS. Methods A retrospective review of all patients who suffered unilateral high-grade renal trauma (grade 3 or higher) from 9/1977 to 8/2012 at San Francisco General Hospital in San Francisco, CA was performed...
December 1, 2017: Urology
https://www.readbyqxmd.com/read/29202940/genitourinary-syndrome-of-menopause-management-strategies-for-the-clinician
#16
REVIEW
Stephanie S Faubion, Richa Sood, Ekta Kapoor
Genitourinary syndrome of menopause (GSM), previously known as atrophic vaginitis or vulvovaginal atrophy, affects more than half of postmenopausal women. Caused by low estrogen levels after menopause, it results in bothersome symptoms, including vaginal dryness, itching, dyspareunia, urinary urgency and increased frequency, and urinary tract infections. Even though women with GSM can have sexual dysfunction that interferes with partner relationships, women are often embarrassed to seek treatment, and health care professionals do not always actively screen for GSM...
December 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29198325/ercc1-as-a-prognostic-factor-for-survival-in-patients-with-advanced-urothelial-cancer-treated-with-platinum-based-chemotherapy-a-systematic-review-and-meta-analysis
#17
REVIEW
Yuksel Urun, Jeffrey J Leow, Andre P Fay, Laurence Albiges, Toni K Choueiri, Joaquim Bellmunt
BACKGROUND: The predictive role of excision repair cross-complementing group 1 (ERCC1) as a predictive factor in patients with advanced urothelial cancer (AUC) treated with platinum-based treatment is not well defined. Here, we evaluate the role of ERCC1 in patients with AUC treated with platinum-based treatment. METHODS: We performed comprehensive, systematic computerized search to identify relevant studies through Medline, Embase, Cochrane Controlled Trials Register (CCTR) databases and abstracts from American Society of Clinical Oncology (ASCO) and ASCO Genitourinary Cancers Symposium, European Society For Medical Oncology (ESMO) and European Association of Urology (EAU) meeting up to July 2015...
December 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/29198006/characteristics-of-pi-rads-4-lesions-within-the-prostatic-peripheral-zone-a-retrospective-diagnostic-accuracy-study-evaluating-170-lesions
#18
Prasad R Shankar, Nicole E Curci, Matthew S Davenport
PURPOSE: To determine whether peripheral zone PI-RADS 4 observations can be further risk-stratified. METHODS: This was an IRB-approved HIPAA-compliant retrospective diagnostic accuracy study. Peripheral zone PI-RADS 4 observations prospectively identified at the study institution from 8/1/2015 to 12/31/2016 (n = 170 in 149 mpMRIs) were reviewed independently by two blinded genitourinary radiologists on the basis of (a) PI-RADS v2 shape, (b) pattern of peripheral zone sparing, and (c) rationale for PI-RADS 4 designation...
December 2, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29196453/physician-preferences-surrounding-urinary-tract-infection-management-in-neonates
#19
Neha S Joshi, Brian P Lucas, Alan R Schroeder
OBJECTIVES: Variability exists in the treatment of neonates with urinary tract infection (UTI), potentially reflecting an overuse of resources. A cross-sectional vignette survey was designed to examine variability in physician preferences for intravenous (IV) antibiotic duration, genitourinary imaging, and prophylactic antibiotics and to evaluate drivers of resource use. METHODS: The survey was administered to a random sample of pediatricians through the American Medical Association's Physician Masterfile...
December 1, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/29196150/sglt2-inhibitors-with-cardiovascular-benefits-transforming-clinical-care-in-type2-diabetes-mellitus
#20
REVIEW
Michael d'Emden, John Amerena, Gary Deed, Carol Pollock, Mark E Cooper
Cardiovascular risk reduction in individuals with Type 2 diabetes mellitus (T2DM) is a key part of clinical management. Sodium-glucose co-transporter (SGLT2) inhibitors improve glycaemic control, reduce body weight and decrease blood pressure. In addition, the SGLT2 inhibitors empagliflozin and canagliflozin reduced the risk of composite cardiovascular events in high-risk individuals with T2DM in the EMPA-REG OUTCOME trial and the CANVAS Program, respectively. Empagliflozin also reduced cardiovascular deaths and improved renal outcomes...
November 28, 2017: Diabetes Research and Clinical Practice
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