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https://www.readbyqxmd.com/read/28319315/maxillofacial-features-and-systemic-malformations-in-expanded-spectrum-hemifacial-microsomia
#1
Noah Cohen, Erica Cohen, Alberto Gaiero, Silvia Zecca, Graziella Fichera, Federica Baldi, Joseph Felix Giordanetto, Jacques Marie Mercier, Amnon Cohen
Hemifacial microsomia (HFM) is a rare, multisystemic congenital disease with estimated frequency of 1/26370 births in Europe. Most cases are sporadic and caused by unilateral abnormal morphogenesis of the first and second pharyngeal arches. The aim of this study is to define the types and frequency of maxillofacial and systemic malformations in HFM patients. This is a case series study of patients with HFM evaluated at a single institution. Data were acquired through history, physical examination, photographs, diagnostic radiology, and laboratory and analyzed by the FileMakerPro database on 95 patients (54F; 41M) of which 89 met the inclusion criteria...
March 20, 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28314972/-rare-diseases-with-clinical-relevance-the-silver-russell-syndrome
#2
C Neissner, C Schepp, W H Rösch
The Silver-Russell syndrome (SRS) is a rare imprinting disease associated with pre- and postnatal growth retardation, craniofacial features, and asymmetry. Genitourinary abnormalities are seen in up to 20% of affected individuals. Apart from structural renal anomalies, cryptorchidism and hypospadias occur frequently in boys, while girls often have anomalies similar to those in Mayer-Rokitansky-Küster-Hauser syndrome with congenital hypoplasia or aplasia of the uterus and upper part of the vagina. Frequently hypospadias repair and orchiopexy are difficult because of lack of buccal mucosa due to facial dysmorphism and intraabdominal position of the testicles, respectively...
March 17, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28314701/genitourinary-involvement-and-management-in-children-with-stevens-johnson-syndrome-and-toxic-epidermal-necrolysis
#3
J P Van Batavia, D I Chu, C J Long, M Jen, D A Canning, D A Weiss
BACKGROUND: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are devastating hypersensitivity disorders that cause epidermal cell death and can affect all epidermal surfaces, including the urethra, vagina, labial and scrotal skin. Despite the well-described ocular and orofacial manifestations of SJS/TEN, there is a paucity of reports on the genitourinary (GU) symptoms and their management. Specifically, consulting services often ask the pediatric urology team if it is safe to place a urethral catheter, but there is no data in the literature to help guide management...
February 27, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28306195/influence-of-caudal-block-on-postoperative-oliguria-in-infants-undergoing-bilateral-ureteroneocystostomy-a-retrospective-analysis
#4
Hyun Jeong Lee, Yong Seon Choi, Bon-Nyeo Koo, Sang Won Han, Young Eun Cho, Young Jae Im, Jae Hoon Lee
BACKGROUND: Caudal block has been widely used in children undergoing genitourinary surgery. However, the influence of caudal block on postoperative oliguria is unclear. AIM: The aim of this study was to assess the effect of caudal block on urinary flow through the reimplanted ureter after ureteroneocystostomy and the incidence of postoperative oliguria in infants. METHODS: This retrospective study analyzed the medical records of 121 infants aged less than 12 months who underwent bilateral ureteroneocystostomy for vesicoureteral reflux at a tertiary medical center...
March 17, 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28302349/influence-of-pathologist-experience-on-positive-surgical-margins-following-radical-prostatectomy
#5
Jacob E Tallman, Vignesh T Packiam, Kristen E Wroblewski, Gladell P Paner, Scott E Eggener
BACKGROUND: A positive surgical margin (PSM) following radical prostatectomy (RP) for prostate cancer is associated with increased risk of biochemical recurrence. We sought to examine whether the pathologist is an independent predictor of PSMs. METHODS: We performed a retrospective review of 3,557 men who underwent RP for localized prostate cancer at our institution from 2003 to 2015. We evaluated 29 separate pathologists. Univariate and multivariable logistic regression were used to test variables previously shown to influence PSM rates...
March 13, 2017: Urologic Oncology
https://www.readbyqxmd.com/read/28301463/increasing-prevalence-of-genitourinary-schistosomiasis-in-europe-in-the-migrant-era-neglected-no-more
#6
Niccolò Riccardi, Francesca Nosenzo, Francesca Peraldo, Francesca Sarocchi, Lucia Taramasso, Paolo Traverso, Claudio Viscoli, Antonio Di Biagio, Lorenzo E Derchi, Andrea De Maria
No abstract text is available yet for this article.
March 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28301211/clinical-and-imaging-features-of-noncutaneous-melanoma
#7
Vincenzo K Wong, Meghan G Lubner, Christine O Menias, Vincent M Mellnick, Tabassum A Kennedy, Sanjeev Bhalla, Perry J Pickhardt
OBJECTIVE: The purpose of this article is to summarize the epidemiologic characteristics, clinical aspects, and radiologic appearance of as well as the management considerations and differential diagnoses for noncutaneous primary melanomas occurring at specific anatomic sites. Primary ocular, sinonasal, meningeal, biliary, adrenal, alimentary tract, and genitourinary melanomas are highlighted. CONCLUSION: Noncutaneous primary melanomas are a complex group of malignancies with biologic findings that are unique when compared with findings for cutaneous melanomas...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28301210/update-of-dual-energy-ct-applications-in-the-genitourinary-tract
#8
Ravi K Kaza, Lakshmi Ananthakrishnan, Avinash Kambadakone, Joel F Platt
OBJECTIVE: Dual-energy CT (DECT) is being increasingly used for abdominal imaging because it provides incremental benefit of material characterization without significant increase in radiation dose. This article provides an overview of current DECT techniques and use of DECT in urinary tract imaging for assessment of renal masses and urinary calculi characterization and in CT urography. CONCLUSION: Incorporation of DECT into clinical practice and use of its material characterization capabilities in urinary tract imaging enable characterization of urinary calculi and incidental renal lesions and can reduce radiation dose by allowing generation of virtual unenhanced images...
March 16, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28300036/-inflammatory-myofibroblastic-genitourinary-tumor-the-challenge-of-controlling-and-monitoring-an-non-frequent-oncological-disease
#9
Luis Rico, Francisco Miguel López, Gonzalo Vitagliano, Ameri Carlos
OBJECTIVE: The inflammatory myofibroblastic tumor (IMT) is a neoplasia with intermediate biological potential, infrequent, with an unpredictable clinical prognosis and a low recurrence rate after an effective treatment. We report two cases of IMT with genitourinary localization, being this entit's publications infrequent. Both presented with little symptomatology, leading to multiple differential diagnosis. The surgical treatment was chosen and pathologic result confirmed the diagnosis...
March 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28296582/randomized-trial-of-a-hypofractionated-radiation-regimen-for-the-treatment-of-localized-prostate-cancer
#10
Charles N Catton, Himu Lukka, Chu-Shu Gu, Jarad M Martin, Stéphane Supiot, Peter W M Chung, Glenn S Bauman, Jean-Paul Bahary, Shahida Ahmed, Patrick Cheung, Keen Hun Tai, Jackson S Wu, Matthew B Parliament, Theodoros Tsakiridis, Tom B Corbett, Colin Tang, Ian S Dayes, Padraig Warde, Tim K Craig, Jim A Julian, Mark N Levine
Purpose Men with localized prostate cancer often are treated with external radiotherapy (RT) over 8 to 9 weeks. Hypofractionated RT is given over a shorter time with larger doses per treatment than standard RT. We hypothesized that hypofractionation versus conventional fractionation is similar in efficacy without increased toxicity. Patients and Methods We conducted a multicenter randomized noninferiority trial in intermediate-risk prostate cancer (T1 to 2a, Gleason score ≤ 6, and prostate-specific antigen [PSA] 10...
March 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28295519/single-nucleotide-polymorphisms-associated-with-nonsyndromic-cryptorchidism-in-mexican-patients
#11
M Chávez-Saldaña, R M Vigueras-Villaseñor, E Yokoyama-Rebollar, D A Landero-Huerta, J C Rojas-Castañeda, L Taja-Chayeb, J O Cuevas-Alpuche, E Zambrano
Cryptorchidism is a frequent genitourinary malformation considered as an important risk factor for infertility and testicular malignancy. The aetiology of cryptorchidism is multifactorial in which certain SNPs, capable of inhibiting the development of the gubernaculum, are implicated. We analysed 16 SNPs by allelic discrimination and automated sequencing in 85 patients and 99 healthy people, with the objective to identify the association between these variants and isolated cryptorchidism. In two different patients with unilateral cryptorchidism, we found the variants rs121912556 and p...
March 10, 2017: Andrologia
https://www.readbyqxmd.com/read/28293790/deconstructing-the-genitourinary-syndrome-of-menopause
#12
Pedro Vieira-Baptista, Claudia Marchitelli, Hope K Haefner, Gilbert Donders, Faustino Pérez-López
The concept of genitourinary syndrome of menopause (GSM) was recently introduced and has been gaining widespread use. While some justifications for its introduction are straightforward, others may be questionable. Numerous unspecific symptoms and signs were included in the definition of the syndrome, but the minimum number required for diagnosis was not established. While the GSM definition is designed to facilitate identifying vulvovaginal and urinary estrogen-deprivation-associated symptoms and signs, several concerns have evolved: (1) the syndrome may result in the underdiagnosis of vulvar and urinary pathology; and (2) serious conditions (e...
March 14, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28291510/prevalence-and-predictors-of-prescription-of-antibiotics-in-pregnant-women-treated-by-gynecologists-in-germany%C3%A2
#13
Louis Jacob, Matthias Kalder, Karel Kostev
AIM: The aim of this study is to estimate the prevalence and potential predictors of the prescription of antibiotics in pregnant women treated by gynecologists in Germany. METHODS: The current study included 90,312 women aged between 18 and 45 years with a full-term documented pregnancy during the index period (2005 - 2014). The primary outcome was the proportion of pregnant women with antibiotic prescriptions. Potential predictors of antibiotic prescriptions considered in the present analysis were age, index year, and gynecological/urinary disorders...
March 14, 2017: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/28291064/scrotal-melanoma-a-systematic-review-of-presentation-treatment-and-outcomes
#14
Joseph Zikry, Lance W Chapman, Dorota Z Korta, Janellen Smith
BACKGROUND: Primary male genital melanomas are rare. Of these, scrotal melanoma is the least common, and is unfortunately often detected late in the disease course. OBJECTIVE: To assess the clinical presentation, treatment modalities, and outcome of scrotal melanoma to aid clinician management. METHODS: Systematic literature review of PubMed, yielding 23 cases, of which 20 met the inclusion criteria. RESULTS: Although previously thought to have the best outcome of genitourinary melanomas, scrotal melanomas are associated with high mortality and late presentation...
March 13, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28290968/management-of-post-traumatic-rectovesical-rectourethral-fistulas-case-series-of-complicated-injuries-in-wounded-warriors-and-review-of-the-literature
#15
Walter B Kucera, James R Jezior, James E Duncan
INTRODUCTION: Penetrating injuries to the pelvis and perineum can result in fistulas between the rectum and lower urinary tract. These injuries are often complicated, which creates challenges for successful repair. Operative strategies may include initial fecal and/or urinary diversion combined with an eventual trans-perineal, trans-anal, or posterior/transrectal approach, but the selected approach should be guided by precise anatomic localization of the injury. We aim to discuss different possible repair strategies as well as the relevant data surrounding gastrointestinal-genitourinary (GI-GU) fistula management...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28290458/from-the-meeting-orlando-plays-host-to-the-2017-asco-genitourinary-cancer-symposium
#16
Annette Fenner
No abstract text is available yet for this article.
March 14, 2017: Nature Reviews. Urology
https://www.readbyqxmd.com/read/28287942/fdg-pet-ct-pitfalls-in-gynecologic-and-genitourinary-oncologic-imaging
#17
Amish Lakhani, Sairah R Khan, Nishat Bharwani, Victoria Stewart, Andrea G Rockall, Sameer Khan, Tara D Barwick
The role of whole-body positron emission tomography (PET)/computed tomography (CT) with fluorodeoxyglucose ( FDG fluorodeoxyglucose ) is now established in the assessment of many gynecologic and genitourinary malignant tumors. FDG fluorodeoxyglucose PET/CT has been widely adopted for staging assessments in patients with suspected advanced disease, in cases of suspected disease recurrence, and for determining prognosis in a number of malignancies. A number of pitfalls are commonly encountered when reviewing FDG fluorodeoxyglucose PET/CT scans in gynecologic and genitourinary cases; these pitfalls can be classified into those that yield potential false-positive or false-negative results...
March 2017: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/28287596/generation-of-fluorescent-protein-fusions-in-candida-species
#18
Sara Gonia, Judith Berman, Cheryl A Gale
Candida species, prevalent colonizers of the intestinal and genitourinary tracts, are the cause of the majority of invasive fungal infections in humans. Thus, molecular and genetic tools are needed to facilitate the study of their pathogenesis mechanisms. PCR-mediated gene modification is a straightforward and quick approach to generate epitope-tagged proteins to facilitate their detection. In particular, fluorescent protein (FP) fusions are powerful tools that allow visualization and quantitation of both yeast cells and proteins by fluorescence microscopy and immunoblotting, respectively...
March 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28286074/human-penile-transplantation-an-emerging-therapy-for-genitourinary-reconstruction
#19
REVIEW
Nikolai A Sopko, Sami H Tuffaha, Denver Lough, Gerald Brandacher, W P Andrew Lee, Trinity J Bivalacqua, Richard J Redett, Arthur L Burnett
PURPOSE: Reconstruction of complex functional structures is increasingly being performed with vascularized composite allo-transplantation (VCA). Penile transplantation is a novel VCA treatment option for severe penile tissue loss and disfigurement. Three allogeneic human penile transplantations have been reported. We review these cases as well as penile transplant indications, pre-clinical models, and immunosuppression therapy. MATERIALS AND METHODS: We performed a comprehensive literature review for the years 1970 to 2016 via MEDLINE, PubMed, and Google with the key words "penis transplantation", "penile rejection", "penile replantation", "penile tissue loss", and "penis vascularized composite allo-transplantation"...
March 9, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28285543/feelings-of-unattractiveness-in-peri-and-postmenopausal-women-are-associated-with-depressed-mood-poor-memory-and-unsatisfactory-sexual-relationships
#20
M Terauchi, A Hirose, M Akiyoshi, K Kato, N Miyasaka
OBJECTIVES: This study aimed to investigate the prevalence of, and risk factors associated with, the feeling of unattractiveness in peri- and postmenopausal women. METHODS: The records of 351 women aged 40-76 who enrolled in a health and nutrition education program at a menopause clinic were analyzed in a cross-sectional manner. Perceptions of unattractiveness were estimated according to responses for the item 'feeling less attractive than before' on the Menopausal Health-Related Quality of Life Questionnaire...
March 11, 2017: Climacteric: the Journal of the International Menopause Society
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