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https://www.readbyqxmd.com/read/28719614/beat-id-towards-a-computationally-low-cost-single-heartbeat-biometric-identity-check-system-based-on-electrocardiogram-wave-morphology
#1
Joana S Paiva, Duarte Dias, João P S Cunha
In recent years, safer and more reliable biometric methods have been developed. Apart from the need for enhanced security, the media and entertainment sectors have also been applying biometrics in the emerging market of user-adaptable objects/systems to make these systems more user-friendly. However, the complexity of some state-of-the-art biometric systems (e.g., iris recognition) or their high false rejection rate (e.g., fingerprint recognition) is neither compatible with the simple hardware architecture required by reduced-size devices nor the new trend of implementing smart objects within the dynamic market of the Internet of Things (IoT)...
2017: PloS One
https://www.readbyqxmd.com/read/28719299/conventional-wisdom-versus-actual-outcomes-challenges-in-the-conduct-of-an-ebola-vaccine-trial-in-liberia-during-the-international-public-health-emergency
#2
Gregg S Larson, Beth R Baseler, Marie L Hoover, Jerome F Pierson, Jemee K Tegli, Melvin P Johnson, Mark W S Kieh, Laura A McNay, Wissedi Sio Njoh
Clinical trials are challenging endeavors. Planning and implementing an investigational vaccine trial in Liberia, in the midst of an Ebola virus disease (EVD) epidemic that World Health Organization classified a public health emergency of international concern, presented extraordinary challenges. Normally, years of preparation and a litany of tasks lay the groundwork for a successful, randomized, blinded, placebo-controlled trial focused on safety and efficacy. Difficult research settings, unpredictable events, and other unique circumstances can add complexity...
July 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28716820/complex-object-motion-represented-by-context-dependent-correlated-activity-of-visual-interneurones
#3
Paul C Dick, Nicole L Michel, John R Gray
Accurate and adaptive encoding of complex, dynamic visual information is critical for the survival of many animals. Studies across a range of taxa have investigated behavioral and neuronal responses to objects that represent a threat, such as a looming object approaching along a direct collision course. By investigating neural mechanisms of avoidance behaviors through recording multineuronal activity, it is possible to better understand how complex visual information is represented in circuits that ultimately drive behaviors...
July 2017: Physiological Reports
https://www.readbyqxmd.com/read/28716166/invited-review-helping-dairy-farmers-to-improve-economic-performance-utilizing-data-driving-decision-support-tools
#4
V E Cabrera
The objective of this review paper is to describe the development and application of a suite of more than 40 computerized dairy farm decision support tools contained at the University of Wisconsin-Madison (UW) Dairy Management website http://DairyMGT.info. These data-driven decision support tools are aimed to help dairy farmers improve their decision-making, environmental stewardship and economic performance. Dairy farm systems are highly dynamic in which changing market conditions and prices, evolving policies and environmental restrictions together with every time more variable climate conditions determine performance...
July 18, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28716135/assessing-the-link-between-implementation-fidelity-and-health-outcomes-for-a-trial-of-intensive-case-management-by-community-health-workers-a-mixed-methods-study-protocol
#5
Barbara Schmidt, Kerrianne Watt, Robyn McDermott, Jane Mills
BACKGROUND: Better systems of care are required to address chronic disease in Indigenous people to ensure they can access all their care needs. Health research has produced evidence about effective models of care and chronic disease strategies to address Indigenous health, however the transfer of research findings into routine clinical practice has proven challenging. Complex interventions, such as those related to chronic disease, have many components that are often poorly implemented and hence rarely achieve implementation fidelity...
July 17, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28715755/adsorption-of-mercury-ii-from-aqueous-solutions-using-fes-and-pyrite-a-comparative-study
#6
Yue Sun, Dan Lv, Jiasheng Zhou, Xiaoxin Zhou, Zimo Lou, Shams Ali Baig, Xinhua Xu
In this study, a comparative evaluation of synthetic FeS and natural pyrite was performed to investigate their adsorptive potentials toward Hg(II) in aqueous system. Characterization analyses such as BET, SEM and TEM suggested that FeS had porous structures with abundant active sites, while pyrite with a hard and smooth surface relied mainly on surface adsorption to immobilize Hg(II). Results of batch tests revealed that FeS offered much greater Hg(II) maximum adsorption capacity (769.2 mg/g) as compared to pyrite (9...
July 11, 2017: Chemosphere
https://www.readbyqxmd.com/read/28714561/service-quality-and-maturity-of-health-care-organizations-through-the-lens-of-complexity-leadership-theory
#7
Ana Horvat, Jovan Filipovic
RATIONALE, AIMS AND OBJECTIVES: This research focuses on Complexity Leadership Theory and the relationship between leadership-examined through the lens of Complexity Leadership Theory-and organizational maturity as an indicator of the performance of health organizations. METHODS: The research adopts a perspective that conceptualizes organizations as complex adaptive systems and draws upon a survey of opinion of 189 managers working in Serbian health organizations...
July 17, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28710673/ensuring-content-validity-of-patient-reported-outcomes-a-shadow-test-approach-to-their-adaptive-measurement
#8
Seung W Choi, Wim J van der Linden
PURPOSE: Most computerized adaptive testing (CAT) applications in patient-reported outcomes (PRO) measurement to date are reliability-centric, with a primary objective of maximizing measurement efficiency. A key concern and a potential threat to validity is that, when left unconstrained, individual CAT administrations could have items with systematically different attributes, e.g., sub-domain coverage. This paper aims to provide a solution to the problem from an optimal test design framework using the shadow-test approach to CAT...
July 14, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/28710528/-anatomy-and-immunology-of-the-eye
#9
U Pleyer, D Pohlmann
The eye has all the mechanisms necessary for detection and processing (afferent immune reaction) as well as adequate initiation of an (efferent) immune response. Apart from the typical antigen-processing cells, locally present elements (e.g. glial cells and retinal pigment epithelium) can also be involved in the afferent reaction. For the efferent mechanisms a complex regulative system exists, which includes cellular and humoral responses and is essentially determined by surface molecules. In addition, the ocular environment is rich in immunosuppressive molecules that contribute to the regulation of immune cells...
July 14, 2017: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/28710326/cortical-influences-drive-amyotrophic-lateral-sclerosis
#10
REVIEW
Andrew Eisen, Heiko Braak, Kelly Del Tredici, Roger Lemon, Albert C Ludolph, Matthew C Kiernan
The early motor manifestations of sporadic amyotrophic lateral sclerosis (ALS), while rarely documented, reflect failure of adaptive complex motor skills. The development of these skills correlates with progressive evolution of a direct corticomotoneuronal system that is unique to primates and markedly enhanced in humans. The failure of this system in ALS may translate into the split hand presentation, gait disturbance, split leg syndrome and bulbar symptomatology related to vocalisation and breathing, and possibly diffuse fasciculation, characteristic of ALS...
July 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28709942/generation-time-and-fitness-trade-offs-during-the-evolution-of-multicellularity
#11
Martin P Leslie, Deborah E Shelton, Richard E Michod
The evolution of multicellular organisms from their unicellular ancestors is an example of an evolutionary transition in individuality (ETI), i.e. a change in the units of selection and adaptation. The theory of ETIs poses particular challenges because, by definition, key theoretical constructs such as fitness are shifting during an ETI. Past work emphasized the importance of life history tradeoffs during ETIs in which lower level units form groups and become individuals at a higher level. In particular, it has been hypothesized that the convexity of the lower-level tradeoff between viability and fecundity changes with group size and determines the optimality of lower-level specialization in the fitness components of the group...
July 11, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28708542/an-ambulatory-gait-monitoring-system-with-activity-classification-and-gait-parameter-calculation-based-on-a-single-foot-inertial-sensor
#12
Minsu Song, Jonghyun Kim
GOAL: For healthcare and clinical use, ambulatory gait monitoring systems using inertial sensors have been developed to estimate the user gait parameters, such as walking speed, stride time, and stride length. However, to adapt the systems effectively to daily-life activities, they need to be able to classify the gait activities of daily-life to obtain the parameters for each activity. In this study, we propose a simple classification algorithm based on a single inertial sensor for ease of use, which classifies three major gait activities: leveled walk, ramp walk, and stair walk...
July 12, 2017: IEEE Transactions on Bio-medical Engineering
https://www.readbyqxmd.com/read/28707282/a-system-to-identify-inhibitors-of-mtor-signaling-using-high-resolution-growth-analysis-in-saccharomyces-cerevisiae
#13
Mitchell B Lee, Daniel T Carr, Michael G Kiflezghi, Yan Ting Zhao, Deborah B Kim, Socheata Thon, Margarete D Moore, Mary Ann K Li, Matt Kaeberlein
The mechanistic target of rapamycin (mTOR) is a central regulator of growth and proliferation and mTOR inhibition is a promising therapy for a variety of diseases and disorders. Inhibition of mTOR complex I (mTORC1) with rapamycin delays aging and increases healthy longevity in laboratory animals and is used clinically at high doses to prevent organ transplant rejection and to treat some forms of cancer. Clinical use of rapamycin is associated with several unwanted side effects, however, and several strategies are being taken to identify mTORC1 inhibitors with fewer side effects...
July 13, 2017: GeroScience
https://www.readbyqxmd.com/read/28706995/disabling-cas9-by-an-anti-crispr-dna-mimic
#14
Jiyung Shin, Fuguo Jiang, Jun-Jie Liu, Nicolas L Bray, Benjamin J Rauch, Seung Hyun Baik, Eva Nogales, Joseph Bondy-Denomy, Jacob E Corn, Jennifer A Doudna
CRISPR (clustered regularly interspaced short palindromic repeats)-Cas9 gene editing technology is derived from a microbial adaptive immune system, where bacteriophages are often the intended target. Natural inhibitors of CRISPR-Cas9 enable phages to evade immunity and show promise in controlling Cas9-mediated gene editing in human cells. However, the mechanism of CRISPR-Cas9 inhibition is not known, and the potential applications for Cas9 inhibitor proteins in mammalian cells have not been fully established...
July 2017: Science Advances
https://www.readbyqxmd.com/read/28704963/challenges-in-wireless-system-integration-as-enablers-for-indoor-context-aware-environments
#15
Peio López-Iturri, Erik Aguirre, Leyre Azpilicueta, José Javier Astrain, Jesús Villandangos, Francisco Falcone
The advent of fully interactive environments within Smart Cities and Smart Regions requires the use of multiple wireless systems. In the case of user-device interaction, which finds multiple applications such as Ambient Assisted Living, Intelligent Transportation Systems or Smart Grids, among others, large amount of transceivers are employed in order to achieve anytime, anyplace and any device connectivity. The resulting combination of heterogeneous wireless network exhibits fundamental limitations derived from Coverage/Capacity relations, as a function of required Quality of Service parameters, required bit rate, energy restrictions and adaptive modulation and coding schemes...
July 12, 2017: Sensors
https://www.readbyqxmd.com/read/28704576/psychosis-an-autoimmune-disease
#16
REVIEW
Adam Aj Al-Diwani, Thomas A Pollak, Sarosh R Irani, Belinda R Lennox
Psychotic disorders are common and disabling. Overlaps in clinical course in addition to epidemiological and genetic associations raise the possibility that autoimmune mechanisms may underlie some psychoses, potentially offering novel therapeutic approaches. Several immune loci including the major histocompatibility complex and B-cell markers CD19 and CD20 achieve genome-wide significance in schizophrenia. Emerging evidence suggests a potential role via neurodevelopment in addition to classical immune pathways...
July 13, 2017: Immunology
https://www.readbyqxmd.com/read/28702123/the-evolution-of-life-a-metadarwinian-integrative-approach
#17
Arnold De Loof
It is undeniably very logical to first formulate an unambiguous definition of "Life" before engaging in defining the parameters instrumental to Life's evolution. Because nearly everybody assumes, erroneously in my opinion, that catching Life's essence in a single sentence is impossible, this way of thinking remained largely unexplored in evolutionary theory. Upon analyzing what exactly happens at the transition from "still alive" to "just dead," the following definition emerged. What we call "Life" (L) is an activity...
2017: Communicative & Integrative Biology
https://www.readbyqxmd.com/read/28701553/walking-like-an-ant-a-quantitative-and-experimental-approach-to-understanding-locomotor-mimicry-in-the-jumping-spider-myrmarachne-formicaria
#18
Paul S Shamble, Ron R Hoy, Itai Cohen, Tsevi Beatus
Protective mimicry, in which a palatable species avoids predation by being mistaken for an unpalatable model, is a remarkable example of adaptive evolution. These complex interactions between mimics, models and predators can explain similarities between organisms beyond the often-mechanistic constraints typically invoked in studies of convergent evolution. However, quantitative studies of protective mimicry typically focus on static traits (e.g. colour and shape) rather than on dynamic traits like locomotion...
July 12, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28699818/implementing-brief-dynamic-interpersonal-therapy-dit-in-a-va-medical-center
#19
Cory K Chen, Christine P Ingenito, Michelle M Kehn, Nicole Nehrig, Karen S Abraham
BACKGROUND: Given increasing mental health needs in the VA, identifying strategies to deliver new services is critical. AIMS: This paper describes the process of navigating provider, patient and systems barriers of an initiative to increase choice, access and quality of psychotherapy at the VA by incorporating an evidence-based short-term, psychodynamic psychotherapy. METHODS: Brief Dynamic Interpersonal Therapy (DIT) was selected as a viable model for implementation...
July 12, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28699060/assessing-the-burden-of-treatment
#20
Gabriela Spencer-Bonilla, Ana R Quiñones, Victor M Montori
Current healthcare systems and guidelines are not designed to adapt to care for the large and growing number of patients with complex care needs and those with multimorbidity. Minimally disruptive medicine (MDM) is an approach to providing care for complex patients that advances patients' goals in health and life while minimizing the burden of treatment. Measures of treatment burden assess the impact of healthcare workload on patient function and well-being. At least two of these measures are now available for use with patients living with chronic conditions...
July 11, 2017: Journal of General Internal Medicine
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