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https://www.readbyqxmd.com/read/28720498/rna-aptamers-targeted-for-human-%C3%AE-a-crystallin-do-not-bind-%C3%AE-b-crystallin-and-spare-the-%C3%AE-crystallin-domain
#1
Prabhat K Mallik, Hua Shi, Jayanti Pande
The molecular chaperones, α-crystallins, belong to the small heat shock protein (sHSP) family and prevent the aggregation and insolubilization of client proteins. Studies in vivo have shown that the chaperone activity of the α-crystallins is raised or lowered in various disease states. Therefore, the development of tools to control chaperone activity may provide avenues for therapeutic intervention, as well as enable a molecular understanding of chaperone function. The major human lens α-crystallins, αA- (HAA) and αB- (HAB), share 57% sequence identity and show similar activity towards some clients, but differing activities towards others...
July 15, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28715415/characterizing-the-malaria-rural-to-urban-transmission-interface-the-importance-of-reactive-case-detection
#2
Karen Molina Gómez, M Alejandra Caicedo, Alexandra Gaitán, Manuela Herrera-Varela, María Isabel Arce, Andrés F Vallejo, Julio Padilla, Pablo Chaparro, M Andreína Pacheco, Ananias A Escalante, Myriam Arevalo-Herrera, Sócrates Herrera Valencia
BACKGROUND: Reported urban malaria cases are increasing in Latin America, however, evidence of such trend remains insufficient. Here, we propose an integrated approach that allows characterizing malaria transmission at the rural-to-urban interface by combining epidemiological, entomological, and parasite genotyping methods. METHODS/PRINCIPAL FINDINGS: A descriptive study that combines active (ACD), passive (PCD), and reactive (RCD) case detection was performed in urban and peri-urban neighborhoods of Quibdó, Colombia...
July 17, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28711218/significant-axial-elongation-with-minimal-change-in-refraction-in-3-to-6-year-old-chinese-preschoolers-the-shenzhen-kindergarten-eye-study
#3
Xinxing Guo, Min Fu, Xiaohu Ding, Ian G Morgan, Yangfa Zeng, Mingguang He
PURPOSE: To document the distribution of ocular biometry and to evaluate its associations with refraction in a group of Chinese preschoolers. DESIGN: Population-based cross-sectional study. PARTICIPANTS: A total of 1133 preschoolers 3 to 6 years of age from 8 representative kindergartens. METHODS: Biometric measurements including axial length (AL), anterior chamber depth (ACD), and corneal radius of curvature (CR) were obtained from partial-coherence laser interferometry (IOL Master; Carl Zeiss Meditec, Oberkochen, Germany) before cycloplegia...
July 13, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28705644/discovery-of-ds79182026-a-potent-orally-active-hepcidin-production-inhibitor
#4
Takeshi Fukuda, Riki Goto, Toshihiro Kiho, Kenjiro Ueda, Sumie Muramatsu, Masami Hashimoto, Anri Aki, Kengo Watanabe, Naoki Tanaka
Hepcidin has emerged as the central regulatory molecule of systemic iron homeostasis. Inhibition of hepcidin could be a strategy favorable to treating anemia of chronic disease (ACD). We report herein the synthesis and structure-activity relationships (SARs) of a series of benzisoxazole compounds as orally active hepcidin production inhibitors. The optimization study of multi kinase inhibitor 1 led to a potent and bioavailable hepcidin production inhibitor 38 (DS79182026), which showed serum hepcidin lowering effects in a mouse IL-6 induced acute inflammatory model...
July 3, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28701920/tlx3-function-in-the-dorsal-root-ganglion-is-pivotal-to-itch-and-pain-sensations
#5
Chengcheng Huang, Fumin Lu, Ping Li, Cheng Cao, Zijing Liu
Itch, a sensation eliciting a desire to scratch, is distinct from but not completely independent of pain. Inspiring achievements have been made in the characterization of itch-related receptors and neurotransmitters, but the molecular mechanisms controlling the development of pruriceptors remain poorly understood. Here, our RNAseq and in situ hybridization data show that the transcription factor Tlx3 is required for the expression of a majority of itch-related molecules in the dorsal root ganglion (DRG). As a result, Tlx3(F/F);Nav1...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28697061/elevation-of-circulating-th17-th22-cells-exposed-to-low-level-formaldehyde-and-its-relevance-to-formaldehyde-induced-occupational-allergic-contact-dermatitis
#6
Weihua Mai, Xingwei Liu, Guangxiao Su, Wenying Zhou, Ziping Wen, Dongqing Lu
OBJECTIVES: The aim of this study was to investigate the effects of formaldehyde exposure on Th17 and Th22 cells and its relevance to human occupational allergic contact dermatitis (OACD). METHODS: Circulating IL17-/IL22-secreting cells and serum IL17/IL22 levels in formaldehyde-exposed workers at Occupational Exposure Limit and nonexposed controls were assessed. RESULTS: The IL17 and IL22 cell population were detected in both CD3CD8 and CD3CD8 cells...
July 10, 2017: Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28694031/in-vivo-induction-of-regulatory-t-cells-promotes-allergen-tolerance-and-suppresses-allergic-contact-dermatitis
#7
Stephen C Balmert, Cara Donahue, John R Vu, Geza Erdos, Louis D Falo, Steven R Little
Allergic contact dermatitis (ACD) is a common T-cell mediated inflammatory skin condition, characterized by an intensely pruritic rash at the site of contact with allergens like poison ivy or nickel. Current clinical treatments use topical corticosteroids, which broadly and transiently suppress inflammation and symptoms of ACD, but fail to address the underlying immune dysfunction. Here, we present an alternative therapeutic approach that teaches the immune system to tolerate contact allergens by expanding populations of naturally suppressive allergen-specific regulatory T cells (Tregs)...
July 8, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28685563/allergic-contact-dermatitis-to-acrylates
#8
P Romita, C Foti, L Masciopinto, E Nettis, E Di Leo, G Calogiuri, D Bonamonte, G Angelini, G Dipalma, A Ballini, F Inchingolo
Acrylates and methacrylates are a large group of chemically reactive monomers that are polymerized into acrylic plastics. These have very broad applications in glues, coatings and various plastic materials. Allergic contact dermatitis (ACD) caused by acrylates can be occupational, mainly in dentistry workers during the manufacturing and implantation of dental prosthesis, and in nail technicians during the sculpturing and application of artificial nails. The clinical manifestations vary according to the location of the contact...
April 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28682726/the-effectiveness-of-calf-muscle-electrostimulation-on-vascular-perfusion-and-walking-capacity-in-patients-living-with-type-2-diabetes-mellitus-and-peripheral-artery-disease
#9
Christian Ellul, Cynthia Formosa, Alfred Gatt, Auon Abbas Hamadani, David G Armstrong
The aim of the study was to explore calf muscle electrostimulation on arterial inflow and walking capacity in claudicants with peripheral artery disease and diabetes mellitus. A prospective, 1-group, pretest-posttest study design was used on 40 high-risk participants (n = 40) who exhibited bilateral limb ischemia (ankle brachial pressure index [ABPI] <0.90), diabetes mellitus, and calf muscle claudication. A program of calf muscle electrical stimulation with varying frequency (1-250 Hz) was prescribed for 1 hour per day for 12 weeks...
June 2017: International Journal of Lower Extremity Wounds
https://www.readbyqxmd.com/read/28681302/hydrocarbon-degradation-potential-and-plant-growth-promoting-activity-of-culturable-endophytic-bacteria-of-lotus-corniculatus-and-oenothera-biennis-from-a-long-term-polluted-site
#10
Małgorzata Pawlik, Barbara Cania, Sofie Thijs, Jaco Vangronsveld, Zofia Piotrowska-Seget
Many endophytic bacteria exert beneficial effects on their host, but still little is known about the bacteria associated with plants growing in areas heavily polluted by hydrocarbons. The aim of the study was characterization of culturable hydrocarbon-degrading endophytic bacteria associated with Lotus corniculatus L. and Oenothera biennis L. collected in long-term petroleum hydrocarbon-polluted site using culture-dependent and molecular approaches. A total of 26 hydrocarbon-degrading endophytes from these plants were isolated...
July 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28673042/independent-prognostic-value-of-left-ventricular-contractile-reserve-and-chronotropic-response-in-patients-with-reduced-left-ventricular-ejection-fraction-undergoing-vasodilator-stress-myocardial-perfusion-imaging-with-rb-82-positron-emission-tomography
#11
Balaji K Tamarappoo, Lee Fong Ling, Manuel Cerqueira, Rory Hachamovitch
Objectives: We evaluated the prognostic value of heart rate reserve (ΔHR) and left ventricular ejection fraction reserve (ΔLVEF) among patients with systolic dysfunction. Background: Inadequate ΔHR (maximal stress HR - resting HR) and ΔLVEF (LVEF at stress - LVEF at rest) in response to stress are associated with adverse cardiac events. However, the significance of an abnormal ΔHR and ΔLVEF in patients with systolic dysfunction has not been described. Methods and results: We performed a retrospective analysis of patients with rest LVEF < 45% who underwent dipyridamole stress-rest gated Rb-82 PET myocardial perfusion imaging (PET-MPI) at the Cleveland Clinic between 2006 and 2009...
June 29, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28665719/eimeria-oocyst-concentrations-and-species-composition-in-litter-from-commercial-broiler-farms-during-anticoccidial-drug-or-live-eimeria-oocyst-vaccine-control-programs
#12
Mark C Jenkins, Carolyn Parker, Donald Ritter
The purpose of this study was to determine if Eimeria oocyst concentrations and species composition in commercial broiler house litter changed during different cycles of anticoccidial drug (ACD) or live Eimeria oocyst vaccine (VAC) control programs and if there was a correlation between Eimeria oocyst levels and broiler performance. Litter samples were collected from a total of 15 different broiler farms encompassing a total of 45 individual houses during at least one complete grow-out cycle over a 21-mo period...
June 2017: Avian Diseases
https://www.readbyqxmd.com/read/28660560/jetstream-atherectomy-and-balloon-angioplasty-with-distal-embolic-protection-for-angio-seal%C3%A2-related-vascular-access-complications
#13
Mihir Barvalia, Mohammad Thawabi, Yassir Nawaz, Nishant Sethi, John Shao, Michael Amponsah, Gautam Visveswaran, Marc Cohen, Najam Wasty
Arteriotomy closure devices (ACDs) are routinely used for vascular closure during invasive cardiovascular procedures. They decrease time to hemostasis as well as length of stay. Major complications such as arterial ischemia and occlusion can be encountered in a minority of patients. We are describing a series of 3 patients with access site closure using Angio-Seal after coronary angiography who developed intermittent claudication within 2-3 weeks of follow-up. Access site thrombosis/stenosis in the CFA was found in all the three cases...
June 28, 2017: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/28656588/allergic-contact-dermatitis-caused-by-meth-acrylates-in-long-lasting-nail-polish%C3%A2-%C3%A2-are-we-facing-a-new-epidemic-in-the-beauty-industry
#14
Maria-Elena Gatica-Ortega, Maria-Antonia Pastor-Nieto, Pedro Mercader-García, Juan-Francisco Silvestre-Salvador
BACKGROUND: Allergic contact dermatitis (ACD) caused by (meth)acrylates has been described both in occupational and in non-occupational settings. OBJECTIVES: To evaluate the clinical patterns, the most frequent allergens and the prognosis in patients sensitized to (meth)acrylates in long-lasting nail polish. METHODS: The files of patients with ACD caused by (meth)acrylates in long-lasting nail polish diagnosed between January 2013 and June 2016 in four dermatology departments in Spain were reviewed...
June 27, 2017: Contact Dermatitis
https://www.readbyqxmd.com/read/28655770/phosphorylation-of-p62-by-amp-activated-protein-kinase-mediates-autophagic-cell-death-in-adult-hippocampal-neural-stem-cells
#15
Shinwon Ha, Seol-Hwa Jeong, Kyungrim Yi, Kyung Min Chung, Caroline Jeeyeon Hong, Seong Who Kim, Eun-Kyoung Kim, Seong-Woon Yu
In the adult brain, programmed death of neural stem cells is considered to be critical for tissue homeostasis and cognitive function and is dysregulated in neurodegeneration. Previously, we have reported that adult rat hippocampal neural (HCN) stem cells undergo autophagic cell death (ACD) following insulin withdrawal. Since the apoptotic capability of the HCN cells was intact, our findings suggested activation of unique molecular mechanisms linking insulin withdrawal to ACD rather than apoptosis. Here, we report that phosphorylation of autophagy-associated protein p62 by AMP-activated protein kinase (AMPK) drives ACD and mitophagy in HCN cells...
June 27, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28654694/ethnic-differences-in-lens-parameters-measured-by-ocular-biometry-in-a-cataract-surgery-population
#16
Dajiang Wang, Behzad Amoozgar, Travis Porco, Zhen Wang, Shan C Lin
PURPOSE: To investigate whether differences exist in lens position and other lens parameters among major ethnic groups with cataractous eyes, which may help explain racial differences in angle closure risk. METHODS: This retrospective, cross-sectional study included 807 adult patients who had cataract surgery between years 2014 and 2016 at the University of California, San Francisco (UCSF). Adult patients of white, Asian, Hispanic and African-American ethnicity were included...
2017: PloS One
https://www.readbyqxmd.com/read/28649264/genome-wide-analysis-of-the-pvhsp20-family-in-switchgrass-motif-genomic-organization-and-identification-of-stress-or-developmental-related-hsp20s
#17
Haidong Yan, Ailing Zhang, Jing Chen, Xiaoyan He, Bin Xu, Guanqi Xie, Zhiming Miao, Xinquan Zhang, Linkai Huang
Hsp20 proteins exist in all plant species and represent the most abundant small heat shock proteins (sHSPs) in plants. Hsp20s were known as chaperones maintaining cellular homeostasis during heat or other kinds of abiotic stresses. The objective of this study was to understand the phylogenetic relationship, genomic organization, diversification of motif modules, genome localization, expression profiles, and interaction networks of switchgrass (Panicum virgatum L.) Hsp20s (PvHsp20s). A total of 63 PvHsp20s were identified with their consensus as well as unique ACD motifs and gene structures analyzed...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28631452/the-impact-of-the-anaesthetic-conserving-device-on-occupational-exposure-to-isoflurane-among-intensive-care-healthcare-professionals
#18
Jennifer Herzog-Niescery, Heike Vogelsang, Philipp Gude, Hans-Martin Seipp, Horst Bartz, Waldemar Uhl, Thomas P Weber, Martin Bellgardt
BACKGROUND: Use of Anesthetic Conserving Devices (ACD) for inhalational isoflurane sedation in intensive care units (ICU) has grown in recent years, and healthcare professionals are concerned about isoflurane pollution and exposure-related health risks. Real-time measurements to determine isoflurane exposure in ICU personnel during short-term patient care procedures and ACD handling have not yet been performed. METHODS: Isoflurane concentrations in the breathing zones of ICU staff (25 cm around the nose and mouth) were measured, by photoacoustic gas monitoring, during daily practice including tracheal suctioning, oral hygiene, body care, and patient positioning...
June 14, 2017: Minerva Anestesiologica
https://www.readbyqxmd.com/read/28613975/activation-of-drd5-dopamine-receptor-d5-inhibits-tumor-growth-by-autophagic-cell-death
#19
Zhi Gen Leng, Shao Jian Lin, Ze Rui Wu, Yu Hang Guo, Lin Cai, Han Bing Shang, Hao Tang, Ya Jun Xue, Mei Qing Lou, Wenxiu Zhao, Wei-Dong Le, Wei Guo Zhao, Xun Zhang, Zhe Bao Wu
Dopamine agonists such as bromocriptine and cabergoline have been successfully used in the treatment of pituitary prolactinomas and other neuroendocrine tumors. However, their therapeutic mechanisms are not fully understood. In this study we demonstrated that DRD5 (dopamine receptor D5) agonists were potent inhibitors of pituitary tumor growth. We further found that DRD5 activation increased production of reactive oxygen species (ROS), inhibited the MTOR pathway, induced macroautophagy/autophagy, and led to autophagic cell death (ACD) in vitro and in vivo...
June 14, 2017: Autophagy
https://www.readbyqxmd.com/read/28611604/on-the-accuracy-of-in-vivo-ethanol-and-acetaldehyde-monitoring-a-key-tile-in-the-puzzle-of-acetaldehyde-as-a-neuroactive-agent
#20
REVIEW
Paolo Enrico, Marco Diana
Over the last 20 years researchers have explored the postulated role of acetaldehyde (ACD) as a mediator of some of the actions of ethanol (EtOH) in the central nervous system (CNS). However, efforts have been hampered mainly by the difficulty of directly measuring in vivo EtOH and ACD levels in the CNS and thus, our knowledge is based on indirect evidences. Although technically challenging, the development of reliable methods for in vivo measurement of ACD and EtOH is of paramount importance to solve the "puzzle of acetaldehyde as a neuroactive agent...
2017: Frontiers in Behavioral Neuroscience
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