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https://www.readbyqxmd.com/read/29348326/symmetry-from-asymmetry-or-asymmetry-from-symmetry
#1
Elizabeth W Kahney, Rajesh Ranjan, Ryan J Gleason, Xin Chen
The processes of DNA replication and mitosis allow the genetic information of a cell to be copied and transferred reliably to its daughter cells. However, if DNA replication and cell division were always performed in a symmetric manner, the result would be a cluster of tumor cells instead of a multicellular organism. Therefore, gaining a complete understanding of any complex living organism depends on learning how cells become different while faithfully maintaining the same genetic material. It is well recognized that the distinct epigenetic information contained in each cell type defines its unique gene expression program...
January 18, 2018: Cold Spring Harbor Symposia on Quantitative Biology
https://www.readbyqxmd.com/read/29342409/development-and-characterization-of-an-allergoid-of-cat-dander-for-immunotherapy
#2
J P Sola, Y Pedreño, A Cerezo, M Peñalver-Mellado
BACKGROUND: Allergy to cats is a frequent cause of sensitization to indoor allergens and currently there are few alternatives to specific immunotherapy with cat native extracts. The objective is to develop and characterize a new allergoid to increase the tools available for use in clinical practice. METHODS: The allergoid cat dander extract (ACD) was developed from a native cat dander extract (NCD) by modification with glutaraldehyde, and the optimal process control was determined by SDS-PAGE, DOT BLOT and determination of free amine groups...
January 13, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29336782/loss-of-gpnmb-causes-autosomal-recessive-amyloidosis-cutis-dyschromica-in-humans
#3
Chi-Fan Yang, Shuan-Pei Lin, Chien-Ping Chiang, Yu-Hung Wu, Weng Siong H'ng, Chun-Ping Chang, Yuan-Tsong Chen, Jer-Yuarn Wu
Amyloidosis cutis dyschromica (ACD) is a distinct form of primary cutaneous amyloidosis characterized by generalized hyperpigmentation mottled with small hypopigmented macules on the trunks and limbs. Affected families and sporadic case subjects have been reported predominantly in East and Southeast Asian ethnicities; however, the genetic cause has not been elucidated. We report here that the compound heterozygosity or homozygosity of GPNMB truncating alleles is the cause of autosomal-recessive ACD. Six nonsense or frameshift mutations were identified in nine individuals diagnosed with ACD...
January 9, 2018: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29335100/risk-factors-for-and-management-of-pupillary-intraocular-lens-capture-after-intraocular-lens-transscleral-fixation
#4
Se Rang Choi, Ji Hoon Jeon, Joon Won Kang, Jang Won Heo
PURPOSE: To analyze risk factors and management of pupillary intraocular lens (IOL) capture after IOL transscleral fixation. SETTING: Department of Ophthalmology, Seoul National University Hospital, Seoul, South Korea. DESIGN: Retrospective case series. METHODS: A chart review was performed of patients who had transscleral fixation of IOLs between January 1, 2012, and December 31, 2013. Eyes were divided into 2 groups depending on whether the IOL was pupillary captured...
December 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/29334799/potential-of-epr-spin-trapping-to-investigate-in-situ-free-radicals-generation-from-skin-allergens-in-reconstructed-human-epidermis-cumene-hydroperoxide-as-proof-of-concept
#5
Salen Kuresepi, Bertrand Vileno, Philippe Turek, Jean-Pierre Lepoittevin, Elena Giménez-Arnau
The first step in the development of skin sensitisation to a chemical, and in the elicitation of further allergic contact dermatitis (ACD), is the binding of the allergen to skin proteins after penetrating into the epidermis. The so-formed antigenic adduct is then recognised by the immune system as foreign to the body. Sensitising organic hydroperoxides derived from autoxidation of natural terpenes are believed to form antigens through radical-mediated mechanisms, although this has not yet been established...
January 15, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29329501/sustained-plasma-hepcidin-suppression-and-iron-elevation-by-anticalin-derived-hepcidin-antagonist-in-cynomolgus-monkey
#6
Andreas M Hohlbaum, Hendrik Gille, Stefan Trentmann, Maria Kolodziejczyk, Barbara Rattenstetter, Coby M Laarakkers, Galina Katzmann, Hans Jürgen Christian, Nicole Andersen, Andrea Allersdorfer, Shane A Olwill, Bernd Meibohm, Laurent P Audoly, Dorine W Swinkels, Rachel P L van Swelm
BACKGROUND AND PURPOSE: Anaemia of chronic disease (ACD) has been linked to iron restricted erythropoiesis imposed by high circulating levels of hepcidin, a 25 amino acid hepatocyte-derived peptide that controls systemic iron homeostasis. Here we report the engineering of the human lipocalin-derived, small protein-based Anticalin PRS-080 hepcidin antagonist with high affinity and selectivity. EXPERIMENTAL APPROACH: Anticalin- and hepcidin-specific pharmacokinetic/pharmacodynamic modelling was used to design and select the suitable drug candidate based on half life extension and duration of hepcidin suppression...
January 12, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29327464/the-expression-of-an-exogenous-acc-deaminase-by-the-endophyte-serratia-grimesii-bxf1-promotes-the-early-nodulation-and-growth-of-common-bean
#7
Maria J Tavares, Francisco X Nascimento, Bernard R Glick, Márcio J Rossi
Ethylene acts as an inhibitor of the nodulation process of leguminous plants. However, some bacteria can decrease deleterious ethylene levels by the action of the enzyme 1-aminocyclopropane-1-carboxylate (ACC) deaminase which degrades ACC, the ethylene precursor in all higher plants. Co-inoculation of rhizobia with endophytes enhances the rhizobial symbiotic efficiency with legumes, improving both nodulation and nitrogen fixation. However, not much is understood about the mechanisms employed by these endophytic bacteria...
January 11, 2018: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29327355/non-occupational-allergic-contact-dermatitis-caused-by-long-lasting-nail-polish-kits-for-home-use-the-tip-of-the-iceberg
#8
María-Elena Gatica-Ortega, María-Antonia Pastor-Nieto, Rocío Gil-Redondo, Elena-Remedios Martínez-Lorenzo, Cristina Schöendorff-Ortega
BACKGROUND: Allergic contact dermatitis (ACD) from (meth)acrylates caused by long lasting nail polish (also known as "permanent", "semi-permanent" or "gel nail polish") has been described both in occupational and non-occupational settings. Inexpensive kits for home use have been available for purchase in many stores or through the Internet. OBJECTIVE: To report on several further cases of consumers sensitised to these nail products. METHODS: Patch test results and evaluation of ingredient labelling of products brought in by the patients...
January 12, 2018: Contact Dermatitis
https://www.readbyqxmd.com/read/29321948/performance-of-an-annular-closure-device-in-a-real-world-heterogeneous-at-risk-lumbar-discectomy-population
#9
Adisa Kuršumović, Stefan Rath
Study design/setting Retrospective analysis of single-center registry outcomes data. Objective Assess the utility of an annular closure device (ACD) as an adjunct to limited discectomy for lumbar disc herniation (LDH). Background Recurrent lumbar disc herniation (rLDH) following limited discectomy persists at clinically significant rates, especially in large annular defect (at least 6 mm width) patients. While the etiology of reherniation is often multifactorial, inadequate annular occlusion remains one of the foremost considerations...
November 6, 2017: Curēus
https://www.readbyqxmd.com/read/29315532/treatment-of-mcpt8dtr-mice-with-high-or-low-dose-diphtheria-toxin-leads-to-differential-depletion-of-basophils-and-granulocyte-macrophage-progenitors
#10
Carole El Hachem, Pierre Hener, Peggy Kirstetter, Jiagui Li, Susan Chan, Mei Li
Basophils have been recently recognized to play important roles in type 2 immune responses during allergies and parasitic infection, largely due to the development of novel tools for the in vivo study of these cells. As such, the genetically-engineered MCPT8DTR mouse line has been used to specifically deplete basophils following treatment with diphtheria toxin (DT). In this study, we showed that DT-injected MCPT8DTR mice exhibited a striking decrease of eosinophils and neutrophils in skin when subjected to a hapten fluorescein isothiocyanate (FITC)-induced allergic contact dermatitis (ACD) experimental protocol...
January 8, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29305764/the-role-and-diagnosis-of-allergic-contact-dermatitis-in-patients-with-atopic-dermatitis
#11
Joshua L Owen, Paras P Vakharia, Jonathan I Silverberg
Patients with atopic dermatitis (AD) have increased penetration of allergens, immune dysregulation (including shared cytokine pathways), and frequent use of emollients and topical medications, all of which may predispose toward developing allergic contact dermatitis (ACD). Recent systematic reviews have suggested that ACD is a significant clinical problem in both children and adults with AD. While this remains controversial, ACD remains an important comorbidity and potential exacerbant of AD in clinical practice...
January 5, 2018: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/29304868/further-characterization-of-adult-sheep-ovarian-stem-cells-and-their-involvement-in-neo-oogenesis-and-follicle-assembly
#12
Hiren Patel, Deepa Bhartiya, Seema Parte
BACKGROUND: Stem cells in the ovary comprise of two distinct populations including very small embryonic-like stem cells (VSELs) and slightly bigger progenitors termed ovarian stem cells (OSCs). They are lodged in ovary surface epithelium (OSE) and are expected to undergo neo-oogenesis and primordial follicle (PF) assembly in adult ovaries. The ovarian stem cells express follicle stimulating hormone (FSH) receptors and are directly activated by FSH resulting in formation of germ cell nests (GCN) in vitro...
January 5, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29299271/the-roles-of-environment-space-and-phylogeny-in-determining-functional-dispersion-of-rodents-rodentia-in-the-hengduan-mountains-china
#13
Yuanbao Du, Zhixin Wen, Jinlong Zhang, Xue Lv, Jilong Cheng, Deyan Ge, Lin Xia, Qisen Yang
The recently described trait-based approach is becoming widely popular for a mechanistic understanding of species coexistence. However, the greatest challenge in functional analyses is decomposing the contributions of different ecological and evolutionary processes (e.g., niche-based process, neutral process, and evolutionary process) in determining trait structure. Taking rodents (Rodentia) in the Hengduan Mountains as our study model, we aim to (1) quantify the vertical patterns of functional structure for head-body length (HL), tail/body ratio (TR), animal component in diet (ACD), and all traits; (2) disentangle the relative importance of different assembly processes (environment, space, and phylogeny) in structuring trait dispersion; and (3) assess the feasibility of Bergmann's rule and Allen's rule along elevational gradient...
December 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29289672/a-multi-omics-analysis-reveals-metabolic-reprogramming-in-thp-1-cells-upon-treatment-with-the-contact-allergen-dncb
#14
Franz Mussotter, Sarah Potratz, Jan Budczies, Andreas Luch, Andrea Haase
Dendritic cell (DC) activation by contact allergens is one of the key steps in the development of allergic contact dermatitis (ACD). Recent evidence suggests that metabolic reprogramming is a prerequisite for the activation of DCs, macrophages and monocytes. Therefore, we used an integrated approach by combining proteomics and metabolomics to investigate the metabolism of human THP-1 cells in response to the strong contact allergen, 2,4-dinitrochlorobenzene (DNCB). Cells were treated with 5, 10 and 20μM DNCB for 4, 8, and 24h, respectively...
December 28, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29288835/evaluation-of-anterior-segment-parameters-in-patients-with-turner-syndrome-using-scheimpflug-imaging
#15
Merve Inanc, Kemal Tekin, Erdal Kurnaz, Mehmet Citirik, Gülsah Altas, Zehra Aycan
PURPOSE: To compare the anterior segment parameters in patients with Turner syndrome (TS) as measured by the Pentacam HR-Scheimpflug imaging system with those of healthy control subjects. METHODS: This cross-sectional prospective study included 35 patients with TS and 30 age-matched controls. Corneal topographic analysis was performed using the Pentacam HR-Scheimpflug imaging system (Oculus, Wetzlar, Germany). The power of the corneal astigmatism, mean keratometry (Km) values for the both front and back surfaces of the cornea, maximum keratometry (Kmax), central corneal thickness (CCT), corneal volume (CoV), white-to-white diameter (WTW), chamber volume (CaV), angle and anterior chamber depth (ACD) values were recorded...
December 27, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/29285706/comparison-of-anterior-segment-parameters-and-axial-lengths-of-myopic-emmetropic-and-hyperopic-children
#16
Mehmethan Dogan, Ufuk Elgin, Emine Sen, Kemal Tekin, Pelin Yilmazbas
PURPOSE: To compare the anterior segment parameters of myopic, hyperopic, and emmetropic children by using optical biometry. METHODS: This prospective cross-sectional study included 150 eyes of 150 children between 6 and 16 years old. The eyes were divided into three groups according to their spherical equivalent (SE) refractive error values as myopic [between - 1.0 and - 6.0 diopter (D)], emmetropic (between + 0.50 and - 0.50 D), and hyperopic (between + 1...
December 29, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/29282578/microrna-21-mediated-inhibition-of-mast-cell-degranulation-involved-in-the-protective-effect-of-berberine-on-2-4-dinitrofluorobenzene-induced-allergic-contact-dermatitis-in-rats-via-p38-pathway
#17
Weihua Li, Fanxiu Liu, Jun Wang, Man Long, Zhigang Wang
The study aimed to investigate the effect of berberine on allergic contact dermatitis (ACD) in rats and explore its underlying mechanisms. Firstly, ACD model was established by sensitizing and challenging with 2,4-dinitrofluorobenzene (DNFB) topically, and the rats were treated with berberine. Ear swelling was assessed, and cytokine, IgE, and histamine productions were measured. The ear biopsies were obtained for histology analysis. Additionally, rat peritoneal mast cells (RPMCs) were isolated for detection of microRNA-21 (miR-21) expression, mitogen-activated protein kinase (MAPK) signaling, and MC degranulation...
December 27, 2017: Inflammation
https://www.readbyqxmd.com/read/29281107/outcomes-of-operative-treatment-for-adult-cervical-deformity-a-prospective-multicenter-assessment-with-1-year-follow-up
#18
Tamir Ailon, Justin S Smith, Christopher I Shaffrey, Han Jo Kim, Gregory Mundis, Munish Gupta, Eric Klineberg, Frank Schwab, Virginie Lafage, Renaud Lafage, Peter Passias, Themistocles Protopsaltis, Brian Neuman, Alan Daniels, Justin K Scheer, Alex Soroceanu, Robert Hart, Rick Hostin, Douglas Burton, Vedat Deviren, Todd J Albert, K Daniel Riew, Shay Bess, Christopher P Ames
BACKGROUND: Despite the potential for profound impact of adult cervical deformity (ACD) on function and health-related quality of life (HRQOL), there are few high-quality studies that assess outcomes of surgical treatment for these patients. OBJECTIVE: To determine the impact of surgical treatment for ACD on HRQOL. METHODS: We conducted a prospective cohort study of surgically treated ACD patients eligible for 1-yr follow-up. Baseline deformity characteristics, surgical parameters, and 1-yr HRQOL outcomes were assessed...
December 21, 2017: Neurosurgery
https://www.readbyqxmd.com/read/29275330/structural-basis-for-substrate-specificity-of-methylsuccinyl-coa-dehydrogenase-an-unusual-member-of-the-acyl-coa-dehydrogenase-family
#19
Thomas Schwander, Richard McLean, Jan Zarzycki, Tobias J Erb
(2S)-methylsuccinyl-CoA dehydrogenase (MCD) belongs to the family of FAD-dependent acyl-CoA dehydrogenase (ACD) and is a key enzyme of the ethylmalonyl-CoA pathway for acetate assimilation. It catalyzes the oxidation of (2S)-methylsuccinyl-CoA to α,β-unsaturated mesaconyl-CoA and shows only about 0.5% activity with succinyl-CoA. Here we report the crystal structure of MCD at a resolution of 1.37 Å. The enzyme forms a homodimer of two 60 kDa subunits. Compared to other ACDs, MCD contains a ~170 residue long N-terminal extension that structurally mimics a dimer-dimer interface of these enzymes that are canonically organized as tetramers...
December 22, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29274020/short-term-change-in-higher-order-aberrations-after-mitomycin-c-augmented-trabeculectomy
#20
Seong Ho Jo, Je Hyun Seo
PURPOSE: To investigate the changes in ocular higher-order aberrations (HOA) after trabeculectomy using mitomycin-C (MMC). METHODS: We retrospectively reviewed data for 63 eyes from 63 glaucoma patients who had undergone MMC augmented trabeculectomy. We measured intraocular pressure (IOP), refractive errors, anterior chamber depth (ACD), and HOA before surgery and 1, 2, and 4 weeks postoperatively. The patients were divided into two groups on the basis of preoperative lens status: phakic and pseudophakic group...
December 22, 2017: International Ophthalmology
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