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https://www.readbyqxmd.com/read/28342908/intestinal-dendritic-cell-licensing-through-tlr4-is-required-for-oral-tolerance-in-allergic-contact-dermatitis
#1
Feriel Hacini-Rachinel, Mercedes Gomez de Agüero, Reem Kanjarawi, Ludovic Moro-Sibilot, Jean-Benoit Le Luduec, Claire Macari, Gilles Boschetti, Emilie Bardel, Philippe Langella, Bertrand Dubois, Dominique Kaiserlian
BACKGROUND: Induction of oral tolerance to haptens is an efficient way to prevent allergic contact dermatitis (ACD) in mice. Toll-like receptor (TLRs)-mediated sensing of the microbiota contributes to gut homeostasis, yet whether it contributes to induction of oral tolerance has not been documented. OBJECTIVE: We examined whether oral tolerance to the contact sensitizer DNFB depends on microbiota/TLRs and evaluated the role of TLR4 on the tolerogenic function of intestinal dendritic cells (DCs)...
March 22, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28342729/repeatability-and-agreement-of-scheimpflug-based-and-swept-source-optical-biometry-measurements
#2
Saadettin Sel, Jana Stange, Delia Kaiser, Laszlo Kiraly
PURPOSE: To evaluate the repeatability and comparability of biometry parameters between a Scheimpflug-based topography with axial length measurement (Pentacam AXL, Oculus, Wetzlar, Germany) and a swept-source optical biometry (IOLMaster 700, Carl Zeiss Meditec AG, Jena, Germany). METHODS: A total of 50 eyes from 50 adult subjects had biometry measurements in one session three times using the Pentacam AXL and the IOLMaster 700. Keratometry, anterior chamber depth (ACD) and axial length (AL) values were obtained by both devices...
March 22, 2017: Contact Lens & Anterior Eye: the Journal of the British Contact Lens Association
https://www.readbyqxmd.com/read/28337056/normative-values-and-contralateral-comparison-of-anterior-chamber-parameters-measured-by-pentacam-and-its-correlation-with-corneal-biomechanical-factors
#3
Mohammad Reza Sedaghat, Vahid Mohammad Zadeh, Kaveh Fadakar, Sakineh Kadivar, Mojtaba Abrishami
PURPOSE: To evaluate the normative values of anterior chamber parameters measured by Pentacam and corneal hysteresis (CH) and corneal resistance factor (CRF) measured by Ocular Response Analyzer (ORA) and their relationship. METHODS: In an observational cross-sectional study, patients aged 18-35 years were included. Exclusion criteria were history of any intraocular or corneal disease, anomaly or surgery; hyperopic spherical refraction more than +3, and myopic spherical refraction less than -5...
January 2017: Saudi Journal of Ophthalmology: Official Journal of the Saudi Ophthalmological Society
https://www.readbyqxmd.com/read/28332379/a-novel-de-novo-pathogenic-variant-in-foxf1-in-a-newborn-with-alveolar-capillary-dysplasia-with-misalignment-of-pulmonary-veins
#4
Youngeun Ma, Mi Ae Jang, Hye Soo Yoo, So Yoon Ahn, Se In Sung, Yun Sil Chang, Chang Seok Ki, Won Soon Park
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV) is an autosomal dominant, fatal developmental disorder of the lungs, with a mortality rate of about 100%. ACD/MPV is caused by mutations in FOXF1. Herein, we describe a newborn boy with ACD/MPV carrying a novel pathogenic variant of FOXF1. The patient developed respiratory distress and severe pulmonary hypertension on the first day of life. Despite aggressive cardiorespiratory management, including veno-venous extracorporeal membrane oxygenation, his condition deteriorated rapidly, and he died within the first month of his life...
May 2017: Yonsei Medical Journal
https://www.readbyqxmd.com/read/28326907/skin-sensitizers-in-cosmetics-and-beyond-potential-multiple-mechanisms-of-action-and-importance-of-t-cell-assays-for-in-vitro-screening
#5
Stanislav Vukmanović, Nakissa Sadrieh
Allergic contact dermatitis (ACD) is a delayed-type hypersensitivity (DTH) reaction induced by repeated contact with sensitizers. The ability of a chemical to act as a sensitizer has most frequently been tested in animals. As the use of animals for these purposes is gradually and globally being phased out, there is a need for reliable in vitro surrogate assays. Currently proposed in vitro assays are designed to test four key events of the adverse outcome pathway (AOP) involving covalent modification of self-proteins by sensitizers (haptenation) and presentation of new antigens (hapten/carrier complexes) to the immune system...
March 22, 2017: Critical Reviews in Toxicology
https://www.readbyqxmd.com/read/28326026/pre-clinical-studies-with-d-penicillamine-as-a-novel-pharmacological-strategy-to-treat-alcoholism-updated-evidences
#6
REVIEW
Alejandro Orrico, Lucía Martí-Prats, María J Cano-Cebrián, Luis Granero, Ana Polache, Teodoro Zornoza
Ethanol, as other drugs of abuse, is able to activate the ventral tegmental area dopamine (VTA-DA) neurons leading to positively motivational alcohol-seeking behavior and use, and, ultimately to ethanol addiction. In the last decades, the involvement of brain-derived acetaldehyde (ACD) in the ethanol actions in the mesolimbic pathway has been widely demonstrated. Consistent published results have provided a mechanistic support to the use of ACD inactivating agents to block the motivational and reinforcing properties of ethanol...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28317681/comparison-of-biometry-and-intraocular-lens-power-calculation-performed-by-a-new-optical-biometry-device-and-a-reference-biometer
#7
Bruna V Ventura, Marcelo C Ventura, Li Wang, Douglas D Koch, Mitchell P Weikert
PURPOSE: To compare biometry measurements and intraocular lens (IOL) power calculations obtained by a new optical A-scan interferometer biometer (Galilei G6) (new biometer) and a partial coherence interferometer biometer (IOLMaster 500) (reference biometer). SETTING: Private practice, Recife, Brazil. DESIGN: Retrospective comparative study. METHODS: Cataract patients who had biometric measurements with the new biometer and the reference biometer were included in the study...
January 2017: Journal of Cataract and Refractive Surgery
https://www.readbyqxmd.com/read/28316463/the-role-of-serotonin-transporter-in-human-lung-development-and-in-neonatal-lung-disorders
#8
E C C Castro, P Sen, W T Parks, C Langston, C Galambos
Introduction. Failure of the vascular pulmonary remodeling at birth often manifests as pulmonary hypertension (PHT) and is associated with a variety of neonatal lung disorders including a uniformly fatal developmental disorder known as alveolar capillary dysplasia with misalignment of pulmonary veins (ACD/MPV). Serum serotonin regulation has been linked to pulmonary vascular function and disease, and serotonin transporter (SERT) is thought to be one of the key regulators in these processes. We sought to find evidence of a role that SERT plays in the neonatal respiratory adaptation process and in the pathomechanism of ACD/MPV...
2017: Canadian Respiratory Journal: Journal of the Canadian Thoracic Society
https://www.readbyqxmd.com/read/28301497/long-term-outcomes-of-ciliary-sulcus-versus-capsular-bag-fixation-of-intraocular-lenses-in-children-an-ultrasound-biomicroscopy-study
#9
Yun-E Zhao, Xian-Hui Gong, Xue-Ning Zhu, He-Ming Li, Meng-Jun Tu, Terry G Coursey, Stephen C Pflugfelder, Feng Gu, Ding Chen
PURPOSE: To evaluate the long-term outcomes of ciliary sulcus versus capsular bag fixation of intraocular lenses (IOLs) in children after pediatric cataract surgery. METHODS: IOL was implanted in the ciliary sulcus in 21 eyes of 14 children, and in the capsular bag in 19 eyes of 12 children for the treatment of pediatric cataract in an institutional setting. Ultrasound biomicroscopy (UBM) was performed. Main outcome measures included IOL decentration, IOL tilt, anterior chamber depth (ACD), angle-opening distance at 500 μm (AOD500), trabecular-iris angle (TIA), best-corrected visual acuity (BCVA), intraocular pressure (IOP), and incidence of postoperative complications...
2017: PloS One
https://www.readbyqxmd.com/read/28296664/histomorphology-and-immunophenotype-of-eczematous-skin-lesions-revisited-skin-biopsies-are-not-reliable-in-differentiating-allergic-contact-dermatitis-irritant-contact-dermatitis-and-atopic-dermatitis
#10
Verena G Frings, Almut Böer-Auer, Kristine Breuer
Lesions of allergic contact dermatitis (ACD), irritant contact dermatitis (ICD), and atopic dermatitis (AD) share similar clinical features and thus, their diagnosis can be challenging. The aim of this study was to reassess histopathology and immunophenotyping properties to distinguish between ACD, ICD, and AD. Charts of patients with eczema, who had undergone complete routine diagnostic workup (skin biopsies, patch tests, skin prick tests, and respectively or serum IgE levels), were reviewed. Thirty-five skin biopsy specimens of 28 patients (mean age 64 ± 15 years; ♀ = 13 ♂ = 15) with clear diagnosis of ACD (n = 15), ICD (n = 6), or AD (n = 14) were analyzed...
March 10, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28296003/a-multicenter-randomized-trial-comparing-the-effectiveness-and-safety-of-a-novel-vascular-closure-device-to-manual-compression-in-anticoagulated-patients-undergoing-percutaneous-transfemoral-procedures-the-celt-acd-trial
#11
Shing Chiu Wong, Michael Laule, Zoltan Turi, Wasiem Sanad, James Crowley, Hubertus Degen, Kathleen Bennett, Jim E Coleman, Geoffrey Bergman
OBJECTIVES: This study compared the performance of Celt ACD(®) , a novel stainless steel based vascular closure device versus manual compression (MC) for femoral arteriotomy site hemostasis in patients undergoing percutaneous coronary procedures. BACKGROUND: Optimal access site management after percutaneous transfemoral procedures remains controversial. METHODS: Patients enrolled in this multicenter, randomized open label trial underwent 6-F diagnostic or interventional procedures and were assigned 2:1 to Celt ACD(®) versus MC...
March 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28290621/contact-sensitization-of-children-referred-to-the-dermatology-department-of-the-university-federico-ii-of-naples-italy-a-two-decade-years-history
#12
Serena Lembo, Claudio Lembo, Cataldo Patruno, Pasquale Cuomo, Fabio Ayala, Nicola Balato, Anna Balato
BACKGROUND: Contact sensitization (CS) and allergic contact dermatitis (ACD) were once thought to be rare in children. The aim of our study was to assess CS and ACD in children affected by eczematous conditions referring to our contact and occupational dermatoses service, and to compare the obtained data to the results of a similar study performed in our Department in late eighties. METHODS: A retrospective analysis of patch test data from the Database of Contact Allergy of the Dermatology Department - University Federico II of Naples was performed...
March 14, 2017: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/28289948/relationship-between-intraocular-pressure-anterior-chamber-depth-and-lens-thickness-in-primary-open-angle-glaucoma-patients
#13
Bolajoko A Adewara, Bernice O Adegbehingbe, Oluwatoyin H Onakpoya, Chidi G Ihemedu
INTRODUCTION: To investigate the relationship between intraocular pressure (IOP), anterior chamber depth (ACD) and lens thickness (LT) in primary open-angle glaucoma (POAG) patients and compare with age- and sex-matched controls. METHODS: A cross-sectional analytical study of 62 newly diagnosed POAG patients compared with 62 age- and sex-matched control subjects in a tertiary eye clinic. Socio-demographic data and ocular examinations were documented. IOP was measured using the Goldmann applanation tonometer...
March 13, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28268050/breaking-symmetry-asymmetric-histone-inheritance-in-stem-cells
#14
REVIEW
Jing Xie, Matthew Wooten, Vuong Tran, Xin Chen
Asymmetric cell division (ACD) gives rise to two daughter cells with distinct fates. ACD is widely used during development and by many types of adult stem cells during tissue homeostasis and regeneration. ACD can be regulated by extrinsic cues, such as signaling molecules, as well as by intrinsic factors, such as organelles and cortex proteins. The recent discovery of asymmetric histone inheritance during stem cell ACD has revealed another intrinsic mechanism by which ACD produces two distinct daughters. In this review we discuss these findings in the context of cell-cycle regulation, as well as other studies of ACD, to begin understanding the underlying mechanisms and biological relevance of this phenomenon...
March 4, 2017: Trends in Cell Biology
https://www.readbyqxmd.com/read/28266677/yb14mgbi11-structure-thermoelectric-properties-and-the-effect-of-the-structure-on-low-lattice-thermal-conductivity
#15
Yufei Hu, Susan M Kauzlarich
Zintl phases Yb14MnSb11 and Yb14MgSb11, which share the same complex structure type, have been demonstrated as the best p-type thermoelectric materials for the high temperature region (800-1200 K). A new iso-structural compound, Yb14MgBi11, was synthesized in order to investigate the structure and thermoelectric properties of the Bi analogs. Yb14MgBi11 crystallizes in the Ca14AlSb11 structure-type with the space group I41/acd [a = 16.974(2) Å, c = 22.399(4) Å, V = 6454(2) Å(3), R1/wR2 = 0.0238/0.0475]. The structure follows the previous description of this structure type and the trend observed in previous analogs...
March 21, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28263734/comparison-of-axial-length-corneal-and-anterior-chamber-depth-measurements-of-two-recently-introduced-devices-to-a-known-biometer
#16
Mehdi Shajari, Carla Cremonese, Kerstin Petermann, Pankaj Singh, Michael Müller, Thomas Kohnen
PURPOSE: Evaluate agreement and repeatability of axial length (AL), corneal curvature and anterior chamber depth (ACD) measurements of two new devices, one using Scheimpflug technology combined with partial coherence interferometry (Pentacam AXL from Oculus, Germany) and one using swept-source OCT (IOL Master 700 from Zeiss, Germany) to a widely-used optical biometer (IOL Master 500 from Zeiss, Germany). DESIGN: Prospective, instrument reliability analysis METHODS: Setting: Department of Ophthalmology, Goethe-University, Frankfurt am Main, Germany Study population: 79 eyes of 79 patients Study Procedure: All eyes were measured with the IOL Master 500, the IOL Master 700 and with the Pentacam AXL...
March 2, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28261218/the-t-cell-response-to-the-contact-sensitizer-paraphenylenediamine-is-characterized-by-a-polyclonal-diverse-repertoire-of-antigen-specific-receptors
#17
Theres Oakes, Amy Lee Popple, Jason Williams, Katharine Best, James M Heather, Mazlina Ismail, Gavin Maxwell, Nichola Gellatly, Rebecca J Dearman, Ian Kimber, Benny Chain
Paraphenylenediamine (PPD) is a common component of hair dyes and black henna tattoos and can cause skin sensitization and allergic contact dermatitis (ACD). The cutaneous inflammatory reaction associated with ACD is driven by both CD4+ and CD8+ T cells. However, the characteristics of such responses with respect to clonal breadth and magnitude are poorly defined. In this study, we have characterized the in vitro recall response of peripheral blood T cells prepared from PPD-allergic individuals to a PPD-human serum albumin (HSA) conjugate (PPD-HSA)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28256047/maternal-mutations-of-foxf1-cause-alveolar-capillary-dysplasia-despite-not-being-imprinted
#18
Miguel Alsina Casanova, Ana Monteagudo-Sánchez, Luciana Rodiguez Guerineau, Franck Court, Isabel Gazquez Serrano, Loreto Martorell, Carlota Rovira Zurriaga, Gudrun E Moore, Miho Ishida, Montserrat Castañon, Elisenda Moliner Calderon, David Monk, Julio Moreno Hernando
Alveolar capillary dysplasia with misalignment of pulmonary veins (ACDMPV) is a rare cause of pulmonary hypertension in newborns. Maternally inherited point mutations in Forkhead Box F1 gene (FOXF1), deletions of the gene, or its long-range enhancers on the maternal allele are responsible for this neonatal lethal disorder. Here, we describe monozygotic twins and one full-term newborn with ACD and gastrointestinal malformations caused by de novo mutations of FOXF1 on the maternal-inherited alleles. Since this parental transmission is consistent with genomic imprinting, the parent-of-origin specific monoallelic expression of genes, we have undertaken a detailed analysis of both allelic expression and DNA methylation...
March 3, 2017: Human Mutation
https://www.readbyqxmd.com/read/28255714/imaging-asymmetric-t-cell-division
#19
Mirren Charnley, Sarah M Russell
Asymmetric cell division (ACD) controls cell fate decisions in model organisms such as Drosophila and C. elegans and has recently emerged as a mediator of T cell fate and hematopoiesis. The most appropriate methods for assessing ACD in T cells are still evolving. Here we describe the methods currently applied to monitor and measure ACD of developing and activated T cells. We provide an overview of approaches for capturing cells in the process of cytokinesis in vivo, ex vivo, or during in vitro culture. We provide methods for in vitro fixed immunofluorescent staining and for time-lapse analysis...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28255623/anal-canal-duplication-and-triplication-a-rare-entity-with-different-presentations
#20
P Palazon, V Julia, L Saura, I de Haro, M Bejarano, C Rovira, X Tarrado
Anal canal duplication (ACD) is the rarest of gastrointestinal duplications. Few cases have been reported. Most cases present as an opening in the midline, posterior to the normal anus. The aim of our revision is to contribute with eight new cases, some of them with unusual presentations: five presented as the typical form, one with a perianal nodule, and two presented as two separate orifices (anal canal triplication). Complete excision was performed in all patients with no complications. ACD is the most distal and the least frequent digestive duplication...
March 2, 2017: Pediatric Surgery International
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