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https://www.readbyqxmd.com/read/28943333/finding-discriminative-and-interpretable-patterns-in-sequences-of-surgical-activities
#1
Germain Forestier, François Petitjean, Pavel Senin, Laurent Riffaud, Pierre-Louis Henaux, Pierre Jannin
OBJECTIVE: Surgery is one of the riskiest and most important medical acts that is performed today. Understanding the ways in which surgeries are similar or different from each other is of major interest to understand and analyze surgical behaviors. This article addresses the issue of identifying discriminative patterns of surgical practice from recordings of surgeries. These recordings are sequences of low-level surgical activities representing the actions performed by surgeons during surgeries...
September 21, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/28941582/characterization-of-reconstructed-human-skin-containing-langerhans-cells-to-monitor-molecular-events-in-skin-sensitization
#2
Stephanie Bock, André Said, Gerrit Müller, Monika Schäfer-Korting, Christian Zoschke, Günther Weindl
Human cell-based approaches to assess defined key events in allergic contact dermatitis (ACD) are well-established, but lack cutaneous penetration and biotransformation as well as cellular cross-talk. Herein, we integrated in vitro-generated immature MUTZ-3-derived Langerhans-like cells (MUTZ-LCs) or monocyte-derived LC-like cells (MoLCs) into reconstructed human skin (RHS), consistent of a stratified epidermis formed by primary keratinocytes on a dermal compartment with collagen-embedded primary fibroblasts...
September 20, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28940203/combination-of-cheminformatics-and-bioinformatics-to-explore-the-chemical-basis-of-the-rhizomes-and-aerial-parts-of-dioscorea-nipponica-makino
#3
Xu-Zhao Li, Shuai-Nan Zhang, Xu-Yan Yang
OBJECTIVES: This study was aimed to explore the chemical basis of the rhizomes and aerial parts of Dioscorea nipponica Makino (DN). METHODS: The pharmacokinetic profiles of the compounds from DN were calculated via ACD/I-Lab and PreADMET program. Their potential therapeutic and toxicity targets were screened through the DrugBank's or T3DB's ChemQuery structure search. KEY FINDINGS: Eleven of 48 compounds in the rhizomes and over half of the compounds in the aerial parts had moderate or good human oral bioavailability...
September 21, 2017: Journal of Pharmacy and Pharmacology
https://www.readbyqxmd.com/read/28938906/international-survey-to-identify-diagnostic-needs-to-support-malaria-elimination-guiding-the-development-of-combination-highly-sensitive-rapid-diagnostic-tests
#4
Ana Campillo, Jennifer Daily, Iveth J González
BACKGROUND: In malaria elimination settings, the very low levels of transmission now being attained present challenges that demand new strategies to identify and treat low-density infections in both symptomatic and asymptomatic populations. Accordingly, passive case detection activities need to be supplemented by active case detection (ACD) strategies with more sensitive diagnostic tools. Malaria rapid diagnostic tests (RDTs) have provided low- and middle-income countries with unprecedented access to malaria diagnostics...
September 22, 2017: Malaria Journal
https://www.readbyqxmd.com/read/28935401/long-term-endothelial-cell-loss-in-patients-with-artisan-myopia-and-artisan-toric-phakic-intraocular-lenses-5-and-10-year-results
#5
Soraya M R Jonker, Tos T J M Berendschot, Annick E Ronden, Isabelle E Y Saelens, Noël J C Bauer, Rudy M M A Nuijts
PURPOSE: To evaluate the long-term change in endothelial cell density (ECD) after the implantation of 2 types of rigid iris-fixated phakic intraocular lenses (pIOLs) for the treatment of myopia and astigmatism. DESIGN: Prospective, clinical cohort study. PARTICIPANTS: A total of 507 eyes of 289 patients receiving the Artisan Myopia or Artisan Toric (Ophtec B.V., Groningen, The Netherlands) iris-fixated pIOL for the treatment of myopia or astigmatism at the University Eye Clinic Maastricht as of January 1998...
September 18, 2017: Ophthalmology
https://www.readbyqxmd.com/read/28921924/effects-of-surgical-anatomical-correction-of-pelvic-anterior-compartment-defect-on-lower-urinary-tract-symptoms
#6
Emre Baser, Safak Ozdemirci, Dilek Uysal, Ertugrul Karahanoglu, Akın Sivaslioglu
OBJECTIVE: To evaluate the effects of surgical anatomical correction on lower urinary tract symptoms (LUTS) in patients with a pelvic anterior compartment defect (PACD). METHODS: This prospective study was carried out on 30 women who had stage II-IV PACD. The women were questioned regarding LUTS symptoms such as urgency, urge incontinence, frequency, hesitancy, abnormal emptying, nocturia and dysuria pre and postoperatively. After a 7-month follow up, the comparison of LUTS symptoms with respect to their healing, existence or de novo appearance was performed using the McNemar and Bowner and Wilcoxon signed-rank tests...
September 17, 2017: Lower Urinary Tract Symptoms
https://www.readbyqxmd.com/read/28918435/infant-avoidance-training-alters-cellular-activation-patterns-in-prefronto-limbic-circuits-during-adult-avoidance-learning-ii-cellular-imaging-of-neurons-expressing-the-activity-regulated-cytoskeleton-associated-protein-arc-arg3-1
#7
Nicole Gröger, Anja Mannewitz, Jörg Bock, Susann Becker, Katja Guttmann, Gerd Poeggel, Katharina Braun
Positive and negative feedback learning is essential to optimize behavioral performance. We used the two-way active avoidance (TWA) task as an experimental paradigm for negative feedback learning with the aim to test the hypothesis that neuronal ensembles activate the activity-regulated cytoskeletal (Arc/Arg3.1) protein during different phases of avoidance learning and during retrieval. A variety of studies in humans and other animals revealed that the ability of aversive feedback learning emerges postnatally...
September 16, 2017: Brain Structure & Function
https://www.readbyqxmd.com/read/28918387/prospective-comparative-effectiveness-cohort-study-comparing-two-models-of-advance-care-planning-provision-for-australian-community-aged-care-clients
#8
Karen Margaret Detering, Rachel Zoe Carter, Marcus William Sellars, Virginia Lewis, Elizabeth Anne Sutton
OBJECTIVES: Conduct a prospective comparative effectiveness cohort study comparing two models of advance care planning (ACP) provision in community aged care: ACP conducted by the client's case manager (CM) ('Facilitator') and ACP conducted by an external ACP service ('Referral') over a 6-month period. METHODS: This Australian study involved CMs and their clients. Eligible CM were English speaking, ≥18 years, had expected availability for the trial and worked ≥3 days per week...
September 16, 2017: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/28916480/factors-associated-with-zonular-instability-during-cataract-surgery-in-eyes-with-acute-angle-closure-attack
#9
Junki Kwon, Kyung Rim Sung
PURPOSE: To compare the demographics and ocular characteristics, including anterior segment optical coherence tomography images and zonular instability in eyes with a history of acute angle closure (AAC) attack and subsequent cataract surgery. DESIGN: Retrospective, case-control study METHODS: Total 68 eyes of 56 patients with a history of AAC attack who underwent cataract surgery were enrolled. Fourteen eyes were assigned to the zonular instability (+) group and 54 were assigned to the zonular instability (-) group based on the presence of zonular instability during cataract surgery...
September 12, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28899911/correlation-of-end-tidal-carbon-dioxide-amplitude-spectrum-area-and-coronary-perfusion-pressure-in-a-porcine-model-of-cardiac-arrest
#10
Nicolas Segal, Anja K Metzger, Johanna C Moore, Laura India, Michael C Lick, Paul S Berger, Wanchun Tang, David G Benditt, Keith G Lurie
Amplitude Spectrum Area (AMSA) values during ventricular fibrillation (VF) correlate with myocardial energy stores and predict defibrillation success. By contrast, end tidal CO2 (ETCO2) values provide a noninvasive assessment of coronary perfusion pressure and myocardial perfusion during cardiopulmonary resuscitation (CPR). Given the importance of the timing of defibrillation shock delivery on clinical outcome, we tested the hypothesis that AMSA and ETCO2 correlate with each other and can be used interchangably to correlate with myocardial perfusion in an animal laboratory preclinical, randomized, prospective investigation...
September 2017: Physiological Reports
https://www.readbyqxmd.com/read/28894388/bone-anchored-annular-closure-following-lumbar-discectomy-reduces-risk-of-complications-and-reoperations-within-90-days-of-discharge
#11
Peter Douglas Klassen, Derek Thomas Bernstein, Hans-Peter Köhler, Mark P Arts, Bradley Weiner, Larry E Miller, Claudius Thomé
PURPOSE: The purpose of this study was to evaluate perioperative complications of lumbar discectomy with or without bone-anchored annular closure device (ACD) implant in patients at high risk of recurrent disc herniation. METHODS: This was a post hoc analysis of a randomized controlled trial that compared outcomes of lumbar discectomy with or without additional placement of an ACD. Patients presented with imaging evidence of lumbar disc herniation and radicular pain that was unresponsive to conservative care...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28893659/a-halotolerant-enterobacter-sp-displaying-acc-deaminase-activity-promotes-rice-seedling-growth-under-salt-stress
#12
Anumita Sarkar, Pallab Kumar Ghosh, Krishnendu Pramanik, Soumik Mitra, Tithi Soren, Sanjeev Pandey, Monohar Hossain Mondal, Tushar Kanti Maiti
Agricultural productivity is proven to be hampered by the synthesis of reactive oxygen species (ROS) and production of stress-induced ethylene under salinity stress. One-aminocyclopropane-1-carboxylic acid (ACC) is the direct precursor of ethylene synthesized by plants. Bacteria possessing ACC deaminase activity can use ACC as a nitrogen source preventing ethylene production. Several salt-tolerant bacterial strains displaying ACC deaminase activity were isolated from rice fields, and their plant growth-promoting (PGP) properties were determined...
September 9, 2017: Research in Microbiology
https://www.readbyqxmd.com/read/28889842/effects-of-acupuncture-on-1-chloro-2-4-dinitrochlorobenzene-induced-allergic-contact-dermatitis-in-mice
#13
Cuicui Chen, Xiaozhu Liu, Yinfeng Li, Huankun Liang, Kangyan Li, Jiali Li, Chengwu Cheng, Xianpan Liu, Shuhai Zhong, Laiqing Li, Yan Wang
Allergic contact dermatitis (ACD) is a chronic inflammatory skin disease. Topical corticosteroids are the first-line therapy for ACD despite their significant adverse effects. Acupuncture has been widely used in the treatment of various skin diseases, but its underlying mechanism remains unrevealed. In this study, we investigated the characteristics of acupuncture treatment based on effectiveness and mechanism. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to build AD-like model. Results showed that acupuncture was an effective treatment method in inhibiting inflammatory conditions, serum IgE levels, and expression of proinflammatory cytokine Th2 (IL-4, IL-6), and Th2 (IL-1β, TNF-α) mRNA compared with DNCB treatment...
August 2017: Journal of Acupuncture and Meridian Studies
https://www.readbyqxmd.com/read/28889150/screening-for-skin-sensitizing-allergens-among-patients-with-clinically-suspected-allergic-contact-dermatitis
#14
Zahid Shakoor, Ahlam S Al-Mutairi, Afnan M Al-Shenaifi, Areej M Al-Abdulsalam, Bashayer Z Al-Shirah, Shahad A Al-Harbi
To detect common skin-sensitizing agents among patients experiencing allergic contact dermatitis (ACD). Methods: This was a retrospective study of 152 patients with clinically suspected ACD who underwent patch testing in an allergy clinic at King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia between January 2012 and February 2015. Of these patients, only 74 (48%) patients reacted to one or more contact allergens. This group of patients included 58 (78.4%) women and 16 (21.6%) men (mean age: 37...
September 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28887690/cervical-sagittal-alignment-after-different-anterior-discectomy-procedures-for-single-level-cervical-degenerative-disc-disease-randomized-controlled-trial
#15
Roland D Donk, Hisse Arnts, Wim I M Verhagen, Hans Groenewoud, Andre Verbeek, Ronald H M A Bartels
BACKGROUND: The effect of anterior cervical discectomy without fusion (ACD), ACD with fusion by stand-alone cage (ACDF) or with arthroplasty (ACDA) on cervical sagittal alignment is not known and is the subject of this study. METHODS: A total of 142 adult patients with single-level cervical disease were at random allocated to different procedures: ACD (45), ACDF (47) and ACDA (50). Upright cervical spine radiographs were obtained. Angles of the involved angle and the angle between C2 and C7 were determined...
September 8, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28884731/-optimization-of-the-algorithm-for-the-detection-and-the-differential-non-pharmacological-correction-of-the-risk-factors-and-the-preclinical-stages-of-atherosclerosis-at-the-level-of-the-health-resort-based-primary-care
#16
M A Vartazaryan, A T Bykov, A V Chernyshev, L S Khodasevich
This article presents the results of a comparative prospective study of 276 subjects at the age between 40 and 65 years presenting with risk factors (RF) of atherosclerosis and its preclinical stages (APC). All of them were reckoned to be at a moderate risk of developing APC based on the results of evaluation with the use of the SCORE scale which implied the necessity of their differential non-pharmacological treatment during a two-year period with the application of a variety of preventive therapeutic strategies...
2017: Voprosy Kurortologii, Fizioterapii, i Lechebnoĭ Fizicheskoĭ Kultury
https://www.readbyqxmd.com/read/28861350/refractive-errors-and-biometry-of-primary-angle-closure-disease-in-a-mixed-malaysian-population
#17
Jelinar Mohamed-Noor, Dhaniah Abd-Salam
AIM: To assess the refractive status, anterior chamber depth (ACD) and axial length (AL) of patients with primary angle-closure disease (PACD). METHODS: Retrospective cohort. Data was collected from charts of all PACD patients treated from April 2013 to December 2015. Analysis was done on 137 patient charts with complete biometric data. Patient demographics, PACD type, refractive status (spherical equivalent), ACD and AL were studied. RESULTS: The median age of 137 subjects [53 with primary angle-closure suspects (PACS), 27 with primary angle-closure (PAC) and 57 with primary angle-closure glaucoma (PACG)] was 68y (range 21-88y)...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28860140/lens-power-in-iranian-schoolchildren-a-population-based-study
#18
Hassan Hashemi, Reza Pakzad, Rafael Iribarren, Mehdi Khabazkhoob, Mohammad Hassan Emamian, Akbar Fotouhi
AIMS: To evaluate lens power (LP) in schoolchildren aged 6-12 years. METHODS: This cross-sectional study was conducted in Shahroud, northeast Iran. The students were selected through random cluster sampling and underwent the measurements of biometry, uncorrected and corrected visual acuity, non-cycloplegic and cycloplegic refraction. The LP was calculated using the Bennett formula. RESULTS: Of 6624 invited children, 5620 (84.8%) participated in the study and data of 4870 children were finally analysed...
August 31, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28854269/six-year-changes-in-refraction-and-related-ocular-biometric-factors-in-an-adult-chinese-population
#19
Xiaotong Han, Xinxing Guo, Pei Ying Lee, Ian G Morgan, Mingguang He
PURPOSE: To investigate longitudinal changes in refraction and biometry in Chinese adults. DESIGN: Population-based prospective cohort study. METHODS: 1817 subjects aged ≥ 35 years were randomly recruited from Yuexiu district, Guangzhou, China in 2008. Of which 1595 (87.8%) were reexamined in 2010 and 1427 (78.5%) were reexamined in 2014. Non-cycloplegic automated refraction and visual acuity test were performed at baseline and the 6-year follow-up examination for all participants...
2017: PloS One
https://www.readbyqxmd.com/read/28854079/identification-of-patients-with-statin-intolerance-in-a-managed-care-plan-a-comparison-of-2-claims-based-algorithms
#20
Brandon K Bellows, Amy M Sainski-Nguyen, Cody J Olsen, Susan H Boklage, Scott Charland, Matthew P Mitchell, Diana I Brixner
BACKGROUND: While statins are safe and efficacious, some patients may experience statin intolerance or treatment-limiting adverse events. Identifying patients with statin intolerance may allow optimal management of cardiovascular event risk through other strategies. Recently, an administrative claims data (ACD) algorithm was developed to identify patients with statin intolerance and validated against electronic medical records. However, how this algorithm compared with perceptions of statin intolerance by integrated delivery networks remains largely unknown...
September 2017: Journal of Managed Care & Specialty Pharmacy
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