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https://www.readbyqxmd.com/read/29147767/mechanism-of-accommodation-assessed-by-change-in-precisely-registered-ocular-images-associated-with-concurrent-change-in-auto-refraction
#1
Andrzej Grzybowski, Ronald A Schachar, Magdalena Gaca-Wysocka, Ira H Schachar, Farhad Kamangar, Barbara K Pierscionek
PURPOSE: Our purpose was to determine the changes in anterior chamber depth (ACD) and central lens thickness (CLT) during pharmacologically induced accommodation. METHODS: Following pupillary dilation with phenylephrine 10%, baseline auto-refractions and swept-source optical coherence tomographic biometric images (Zeiss IOLMaster 700) were obtained from the right eyes of 25 subjects aged 19 to 24 years. Pilocarpine 4% and phenylephrine 10% were then instilled into these right eyes...
November 16, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29147719/crystal-chemistry-and-magnetic-properties-of-the-solid-solutions-ca14-xrexmnbi11-re-la-nd-sm-and-gd-ho-x-%C3%A2-0-6-0-8
#2
Alexander Ovchinnikov, Jai Prakash, Svilen Bobev
The new solid solutions Ca14-xRExMnBi11 (RE = La-Nd, Sm, and Gd-Ho; x ≈ 0.6-0.8) were prepared by using a Pb-flux technique and structurally characterized by single-crystal X-ray diffraction. All synthesized materials crystallize in the tetragonal Ca14AlSb11 structure type (space group: I41/acd, Pearson index: tI208). The magnetic responses of all the members of the series were investigated, and for all REs in this study, except for Sm, a ferromagnetic ordering was observed at TC = 35-44 K. The Sm-containing sample shows a ferromagnetic-like transition at 40 K and enters a long-range antiferromagnetic state below 17 K...
November 17, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29147463/acidic-polysaccharide-from-angelica-sinensis-reverses-anemia-of-chronic-disease-involving-the-suppression-of-inflammatory-hepcidin-and-nf-%C3%AE%C2%BAb-activation
#3
Kaiping Wang, Jun Wu, Fang Cheng, Xiao Huang, Fang Zeng, Yu Zhang
Anemia of chronic disease (ACD) is the second most prevalent anemia and frequently occurs in patients with acute or chronic immune activation. In the current study, we evaluated the therapeutic efficacy of Angelica sinensis polysaccharide (ASP) against ACD in rats and the potential mechanisms involved. The results showed that ASP inhibited inflammatory hepcidin in both HepG2 cells and ACD rats by blocking the IL-6/STAT3 and BMP/SMAD pathways. In ACD rats, the administration of ASP increased ferroportin expression, mobilized iron from the liver and spleen, increased serum iron levels, caused an elevation of serum EPO, and effectively relieved the anemia...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29144877/role-of-proteolytic-enzyme-inhibitors-on-carious-and-eroded-dentin-associated-with-a-universal-bonding-system
#4
M C Giacomini, Pmc Scaffa, L P Chaves, Cmp Vidal, T N Machado, H M Honório, L Tjäderhane, L Wang
OBJECTIVES: The aim of this study was to evaluate the effect of proteolytic inhibitors on the bond strength of a universal adhesive system (etch-and-rinse mode) applied to artificial carious and eroded dentin. METHODS: Ninety molars were prepared and randomly divided into three groups according to the substrate: N, no challenges; ACD, artificial carious dentin simulation and ERO, artificial erosion simulation with orange juice. All groups were redivided into three subgroups according to the dentin pretreatment: W, water; CHX, 2% digluconate chlorhexidine; and E-64 (trans-epoxysuccinyl-L-leucylamido-[4-guanidino] butane), 5 μM E-64 inhibitor...
November 2017: Operative Dentistry
https://www.readbyqxmd.com/read/29132974/topical-electrophilic-nitro-fatty-acids-potentiate-cutaneous-inflammation
#5
Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Sonia R Salvatore, Laura K Ferris, Bruce A Freeman, Francisco J Schopfer, Louis D Falo
Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO2), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Given the nitration of unsaturated fatty acids during metabolic and inflammatory processes and the growing use of fatty acids in topical formulations, we sought to further study the effect of nitro-fatty acids on cutaneous inflammation...
November 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29129023/pathomechanisms-of-contact-sensitization
#6
REVIEW
Philipp R Esser, Stefan F Martin
Contact sensitization is the initial process involved in the development of an allergic reaction to xenobiotic environmental substances. Here, we briefly describe the differences between irritant and allergic contact dermatitis. Then, we highlight the essential steps involved in the development of an ACD reaction, i.e., the protein binding of haptens, genetic factors influencing the penetration of sensitizers into the skin, the different mechanisms driving the initial development of an inflammatory cytokine micromilieu enabling the full maturation of dendritic cells, the role of pre- and pro-haptens, antigen presentation and T cell activation via MHC and CD1 molecules, dendritic cell (DC) migration, and potential LC contribution as well as the different T cell subsets involved in ACD...
November 11, 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/29120635/total-synthesis-of-himalensine-a
#7
Heyao Shi, Iacovos N Michaelides, Benjamin Darses, Pavol Jakubec, Quynh Nhu N Nguyen, Robert S Paton, Darren J Dixon
The first enantioselective synthesis of (-)-himalensine A has been achieved in 22 steps. The synthesis was enabled by a novel catalytic, enantioselective prototropic shift / furan Diels-Alder (IMDAF) cascade to construct the ACD tricyclic core. A reductive radical cyclization cascade was utilized to build the B ring, and end game manipulations featuring a molecular oxygen mediated γ-CH oxidation, a Stetter cyclization to access the pendant cyclopentenone and a highly chemoselective lactam reduction delivered the natural product target...
November 9, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/29111821/correlations-of-corneal-optical-densitometry-endothelial-hexagonality-percentage-and-epithelium-thickness
#8
Gökhan Pekel, Fatih Özbakış, Alperen Bahar, Evre Pekel, Ebru Nevin Çetin
PURPOSE: Our aim was to examine the associations between the cornea morphological parameters, endothelial cell density, and anterior chamber measurements. METHODS: This observational study included 50 eyes of 50 healthy volunteers. The thicknesses of corneal epithelium, Bowman's layer, stroma, Descemet's membrane-endothelium complex, and pre-ocular tear film were measured by means of anterior segment optical coherence tomography. The keratometry (K), corneal volume (CV), corneal optical densitometry (COD), iridocorneal angle (ICA), anterior chamber depth (ACD), and anterior chamber volume (ACV) measurements were taken by the Scheimpflug anterior segment imaging...
November 7, 2017: Current Eye Research
https://www.readbyqxmd.com/read/29110606/the-fate-of-in-situ-lens-regeneration-is-determined-by-capsulorhexis-size
#9
X Tan, Z Liu, Y Zhu, C Chen, S Huang, B Chen, Z Lin, J Chen, X Tang, B Qu, X Liu, L Luo, J Deng, F Shang, M Wu, W Chen, H Lin, Y Liu
BACKGROUND AND OBJECTIVE: Lens regeneration is an optimal strategy for cataract patients to regain visual acuity with accommodation. We recently designed a novel, minimally invasive capsulorhexis surgical method for cataract removal that achieved functional lens regeneration in human infants. However, small anterior capsulorhexis requires advanced surgical expertise. To know whether the quality of the regenerated lens can be maintained with enlarged anterior capsulorhexis, we investigated the shape and transparency of the regenerated lenses with different anterior capsulorhexis diameters (ACDs)...
November 5, 2017: Current Molecular Medicine
https://www.readbyqxmd.com/read/29102605/development-and-clinical-accuracy-of-a-new-iol-power-formula-vrf-compared-to-other-formulas
#10
Oleksiy V Voytsekhivskyy
PURPOSE: To develop and compare the accuracy and reproducibility of the VRF IOL power calculation formula with well-known methods. SETTING: Kiev Clinical Ophthalmology Hospital Eye Microsurgery Center, Kiev, Ukraine. DESIGN: Development and validation study. METHODS: This analysis comprised 823 eyes of 823 patients operated on by one surgeon with three hydrophobic different types of lenses (IQ SN60WF (494 eyes), ReSTOR SN6AD1 (169 eyes), Alcon Labs, Fort Worth, TX, USA and AMO Tecnis MF ZMB00 (160 eyes), J&J, Santa-Ana, CA, USA)...
November 1, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29101142/protocol-for-a-national-prevalence-study-of-advance-care-planning-documentation-and-self-reported-uptake-in-australia
#11
Rasa Ruseckaite, Karen M Detering, Sue M Evans, Veronica Perera, Lynne Walker, Craig Sinclair, Josephine M Clayton, Linda Nolte
INTRODUCTION: Advance care planning (ACP) is a process between a person, their family/carer(s) and healthcare providers that supports adults at any age or stage of health in understanding and sharing their personal values, life goals and preferences regarding future medical care. The Australian government funds a number of national initiatives aimed at increasing ACP uptake; however, there is currently no standardised Australian data on formal ACP documentation or self-reported uptake...
November 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29100334/paradoxical-effects-of-137-cs-irradiation-on-pharmacological-stimulation-of-reactive-oxygen-species-in-hippocampal-slices-from-apoe2-and-apoe4-mice
#12
Laura E Villasana, Tunde Akinyeke, Sydney Weber, Jacob Raber
In humans, apoE, which plays a role in repair, is expressed in three isoforms: E2, E3, and E4. E4 is a risk factor for age-related cognitive decline (ACD) and Alzheimer's disease (AD), particularly in women. In contrast, E2 is a protective factor for ACD and AD. E2 and E4 might also differ in their response to cranial (137)Cs irradiation, a form of radiation typically used in a clinical setting for the treatment of cancer. This might be mediated by reactive oxygen species (ROS) in an-apoE isoform-dependent fashion...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098383/repeatability-assessment-of-anterior-segment-biometric-measurements-under-accommodative-and-nonaccommodative-conditions-using-an-anterior-segment-oct
#13
Noelia Martínez-Albert, Jose J Esteve-Taboada, Robert Montés-Micó
PURPOSE: As accommodation is a dynamic process changing anterior ocular structures, we aim to compare the repeatability between the biometric measurements taken with and without accommodation. METHODS: Thirty healthy right eyes were measured in a baseline and an accommodative state using Visante-OCT. Three repeated measurements were taken to obtain central corneal thickness (CCT), anterior chamber depth (ACD), angle-to-angle distance (ATA), iridocorneal angles (IA), and crystalline lens thickness (LT)...
November 2, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29097742/associated-factors-of-acute-primary-angle-closure-glaucoma-in-a-sub-group-of-chinese-people-comparison-between-attack-eyes-and-normal-controls
#14
Lifang Liu, Xinyu Liu, Chukai Huang, Geng Wang, Di Ma, Wanqi Zhang, Ce Zheng, Mingzhi Zhang
Acute primary angle closure glaucoma (APACG) is an ophthalmic emergency that may lead to irreversible blindness. Although efforts were made to control intraocular pressure, disease progression still existed. Anterior segment optical coherence tomography (AS OCT) may provide a new insight into mechanism of APACG. In order to seek out associated factors by AS OCT, We compared anterior segment parameters between 74 APACG and 48 normal eyes. Analysis of variance, principle component analysis and logistic regression were used...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29097052/influence-of-race-on-prenatal-phthalate-exposure-and-anogenital-measurements-among-boys-and-girls
#15
Abby G Wenzel, Michael S Bloom, Celeste D Butts, Rebecca J Wineland, John W Brock, Lori Cruze, Elizabeth R Unal, John R Kucklick, Stephen E Somerville, Roger B Newman
BACKGROUND: Select phthalates have antiandrogenic activity, which raises concern for adverse developmental outcomes given widespread exposure of pregnant women. Investigators have reported associations between maternal urinary phthalates and altered anogenital distance (AGD), a marker of in utero androgen activity, among offspring. However, data assessing the impact of race on these associations is sparse. OBJECTIVES: To evaluate associations between prenatal phthalate exposure and AGD in a racially diverse newborn population...
January 2018: Environment International
https://www.readbyqxmd.com/read/29090045/comparison-between-pentacam-hr-and-orbscan-ii-after-hyperopic-photorefractive-keratectomy
#16
Mahmoud Jabbarvand, Farshad Askarizadeh, Mohamad Reza Sedaghat, Hadi Ghadimi, Bahram Khosravi, Mohammad Aghazadeh Amiri, Foroozan Narooie-Noori
PURPOSE: The aim of this study was to determine the agreement between Pentacam HR (Scheimpflug imaging, Oculus) and Orbscan II (scanning slit topography, Bausch and Lomb) in measuring corneal parameters after photorefractive keratectomy (PRK) for hyperopia. METHODS: In this prospective cross-sectional study, 38 hyperopic eyes undergoing PRK were examined before refractive surgery and 8 to 10 months postoperatively using Pentacam HR and Orbscan II. Ultrasound (US) pachymetry was also used to measure central corneal thickness (CCT)...
October 2017: Journal of Ophthalmic & Vision Research
https://www.readbyqxmd.com/read/29083086/polymerization-shrinkage-and-porosity-profile-of-dual-cure-dental-resin-cements-with-different-adhesion-to-dentin-mechanisms
#17
Adrieli Burey, Paulo José Dos Reis, Bruno Luiz Santana Vicentin, Cássia Cilene Dezan Garbelini, Márcio Grama Hoeppner, Carlos Roberto Appoloni
This research aims to probe the porosity profile and polymerization shrinkage of two different dual cure resin cements with different dentin bonding systems. The self-adhesive resin cement RelyX U200 (named RU) and the conventional Allcem Core (named AC) were analyzed by x-ray microtomography (μCT) and Scanning Electron Microscopy (SEM). Each cement was divided into two groups (n = 5): dual-cured (RUD and ACD) and self-cured (RUC and ACC). μCT demonstrated that the method of polymerization does not influence the porosity profile but the polymerization shrinkage...
October 30, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29081531/sensory-trp-channels-contribute-differentially-to-skin-inflammation-and-persistent-itch
#18
Jing Feng, Pu Yang, Madison R Mack, Dariia Dryn, Jialie Luo, Xuan Gong, Shenbin Liu, Landon K Oetjen, Alexander V Zholos, Zhinan Mei, Shijin Yin, Brian S Kim, Hongzhen Hu
Although both persistent itch and inflammation are commonly associated with allergic contact dermatitis (ACD), it is not known if they are mediated by shared or distinct signaling pathways. Here we show that both TRPA1 and TRPV1 channels are required for generating spontaneous scratching in a mouse model of ACD induced by squaric acid dibutylester (SADBE), a small molecule hapten, through directly promoting the excitability of pruriceptors. TRPV1 but not TRPA1 channels protect the skin inflammation, as genetic ablation of TRPV1 function or pharmacological ablation of TRPV1-positive sensory nerves promotes cutaneous inflammation in the SADBE-induced ACD...
October 30, 2017: Nature Communications
https://www.readbyqxmd.com/read/29079471/discovery-of-ds28120313-as-a-potent-orally-active-hepcidin-production-inhibitor-design-and-optimization-of-novel-4-6-disubstituted-indazole-derivatives
#19
Takeshi Fukuda, Riki Goto, Toshihiro Kiho, Kenjiro Ueda, Sumie Muramatsu, Masami Hashimoto, Anri Aki, Kengo Watanabe, Naoki Tanaka
Hepcidin has emerged as the central regulatory molecule in systemic iron homeostasis, and its inhibition could be a favorable strategy for treating anemia of chronic disease (ACD). Here, we report the design, synthesis and structure-activity relationships (SAR) of a series of 4,6-disubstituted indazole compounds as hepcidin production inhibitors. The optimization study of multi-kinase inhibitor 1 led to the design of a potent and bioavailable hepcidin production inhibitor, 32 (DS28120313), which showed serum hepcidin-lowering effects in an interleukin-6-induced acute inflammatory mouse model...
October 16, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29076574/uk-trends-of-allergic-occupational-skin-disease-attributed-to-fragrances-1996-2015
#20
Rachel L Montgomery, Raymond Agius, Stephen M Wilkinson, Melanie Carder
BACKGROUND: Fragrances are well known to cause allergic contact dermatitis (ACD). Occupationally related cases occur, with certain groups being at higher risk. OBJECTIVE: To investigate the incidence of occupationally related cases of cutaneous fragrance allergy and to evaluate trends. METHOD: Data on incident cases of occupational ACD caused by fragrances between 1996 and 2015 (inclusive) reported to the EPIDERM surveillance scheme were analysed...
October 27, 2017: Contact Dermatitis
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