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https://www.readbyqxmd.com/read/29224257/models-of-care-for-non-invasive-ventilation-in-the-acute-copd-comparison-of-three-tertiary-hospitals-act3-study
#1
Kerry Parker, Vara Perikala, Ali Aminazad, Zheng Deng, Brigitte Borg, Catherine Buchan, Jo Toghill, Louis B Irving, Jeremy Goldin, David Charlesworth, Ajay Mahal, Suhith Illesinghe, Matthew T Naughton, Alan Young
BACKGROUND AND OBJECTIVE: Non-invasive ventilation (NIV) improves clinical outcomes in hypercapnic acute exacerbations of COPD (AECOPD), but the optimal model of care remains unknown. METHODS: We conducted a prospective observational non-inferiority study comparing three models of NIV care: general ward (Ward) (1:4 nurse to patient ratio, thrice weekly consultant ward round), a high dependency unit (HDU) (1:2 ratio, twice daily ward round) and an intensive care unit (ICU) (1:1 ratio, twice daily ward round) model in three similar teaching tertiary hospitals...
December 10, 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/29224252/are-inhaled-steroids-safe-and-effective-for-prevention-or-treatment-of-bronchopulmonary-dysplasia
#2
Eric S Shinwell
Bronchopulmonary Dysplasia (BPD) represents a major threat to the short and long-term health and development of very preterm infants. Unfortunately, despite much study and progress in neonatology in recent years and some modest improvements in survival, both the incidence and severity of BPD remain frustratingly stable (1). This article is protected by copyright. All rights reserved.
December 9, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29224249/pili-annulati-in-a-case-of-rothmund-thomson-syndrome-with-a-novel-frameshift-mutation-in-recql4
#3
B Bhoyrul, H Lindsay, R Robinson, J Stahlschmidt, T Palmer, S Edward, S M Clark
Rothmund-Thomson syndrome (RTS) is a rare autosomal recessive genodermatosis characterised by erythematous patches or plaques and sometimes swelling and blisters, which appear during infancy on photo-exposed sites, usually the cheeks, then progress to poikiloderma. Other features include gastrointestinal disturbance, short stature, sparse scalp hair/eyebrows/eyelashes, skeletal abnormalities, juvenile cataracts, hypogonadism and a susceptibility to malignancy. Two forms have been described: Type I, characterised by poikiloderma, ectodermal dysplasia and juvenile cataracts, negative for the RECQL4 mutation, and Type II, with poikiloderma, congenital bone defects and increased risk of osteosarcoma related to deleterious RECQL4 mutations...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29224242/dermoscopic-observations-in-disseminated-cryptococcosis-with-cutaneous-involvement
#4
M Sławińska, M Hlebowicz, E Iżycka-Świeszewska, M Sikorska, M Sokołowska-Wojdyło, T Smiatacz, R Nowicki, M Sobjanek
A 26-year-old female patient with a history of intravenous drug abuse, diagnosed with acquired immunodeficiency syndrome (AIDS) 6 months before. AIDS defining disease was Pneumocystis jiroveci pneumonia. The patient presented with severely decreased CD4 cell count of 7 cells/mm3 and relatively low HIV viral load of 281 copies/mL. Shortly after initiation of antiretroviral therapy (ART), was diagnosed with disseminated cryptococcosis with central nervous system and skin involvement. This article is protected by copyright...
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29224241/cost-effectiveness-of-bariatric-surgery-in-adolescents-with-severe-obesity-in-the-uk
#5
M Panca, R M Viner, B White, T Pandya, H Melo, M Adamo, R Batterham, D Christie, S Kinra, S Morris
Evidence shows that surgery for severe obesity in adults improves health and psychological functioning, and is cost-effective. Data on bariatric surgery for adolescents with severe obesity are extremely limited, with no evidence on cost-effectiveness. We evaluated the lifetime cost-effectiveness of bariatric surgery compared with no surgery in adolescents with severe obesity from the UK's National Health Service perspective. Eighteen adolescents with body mass index ≥40 kg m-2 who underwent bariatric surgery (laparoscopic Roux en Y Gastric Bypass [RYGB] [N = 9], and laparoscopic Sleeve Gastrectomy [SG] [N = 9]) at University College London Hospitals between January 2008 and December 2013 were included...
December 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29224240/phototherapy-in-france-quantitative-data-2007-2016-from-the-national-health-insurance-register
#6
François Aubin, Jocelyn Courtois, Eve Puzenat, Charlée Nardin, Florence Castelain, Fabien Pelletier, Christelle Gastaldi-Ménager
Phototherapy is a cost-effective treatment with a safe side-effect profile for the management of a wide range of dermatoses. Although one of the most common indications for phototherapy is psoriasis, the use of phototherapy for psoriasis has seen a decline in the U.S.A. Data from the National Ambulatory Medical Care Survey indicate a 94% decrease of physician visits for phototherapy between 1994 and 1998. This article is protected by copyright. All rights reserved.
December 10, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29224237/major-haemorrhage-fatalities-in-the-australian-national-coronial-database
#7
Jacob S Gipson, Erica M Wood, Merrole F Cole-Sinclair, Zoe McQuilten, Neil Waters, Noel W Woodford
OBJECTIVE: The aim of the study is to describe the epidemiology of major bleeding fatalities. METHODS: A case series analysis of Australia's National Coronial Information System was conducted. Keywords were used to search for closed cases of major haemorrhage in the state of Victoria for the period 1 January 2009 to 31 December 2011. Coroners' findings, autopsy reports and police reports of cases were reviewed. Demographic data were extracted, and cases were assigned to a clinical bleeding context...
December 10, 2017: Emergency Medicine Australasia: EMA
https://www.readbyqxmd.com/read/29224227/capacity-oriented-approaches-to-developing-childhood-obesity-interventions-a-systematic-review
#8
B A Foster, E Fu, N Bendiks, C S Gaspard, M Sharifi
Capacity-oriented approaches to health interventions seek to empower the target population or community to manage the health issue themselves using resources they can control. Positive deviance, resilience and asset-based approaches are three such methods of developing and implementing health interventions. This study aimed to review the efficacy of interventions explicitly applying these methods in addressing childhood obesity using adiposity as the primary outcome, measured by standardized body mass index...
December 10, 2017: Clinical Obesity
https://www.readbyqxmd.com/read/29224223/altering-the-school-breakfast-environment-reduces-barriers-to-school-breakfast-participation-among-diverse-rural-youth
#9
Mary O Hearst, Amy Shanafelt, Qi Wang, Robert Leduc, Marilyn S Nanney
BACKGROUND: The purpose is to determine if altering school breakfast policies and the school breakfast environment will positively impact adolescent beliefs of the barriers and benefits of eating breakfast. METHODS: There were 904 adolescents from 16 rural high schools, Minnesota, in the BreakFAST Study who reported eating breakfast fewer than 4 times per week at baseline. Schools were randomized to intervention (N = 8 schools) or delayed intervention (N = 8) condition...
January 2018: Journal of School Health
https://www.readbyqxmd.com/read/29224209/sircle-a-randomised-controlled-cost-comparison-of-self-administered-short-course-isoniazid-and-rifapentine-for-cost-effective-latent-tuberculosis-eradication
#10
Justin T Denholm, Emma S McBryde, Damon Eisen, Alan Street, Elizabeth Matchett, Caroline Chen, Thomas Shultz, Beverly Biggs, Karin Leder
BACKGROUND: Currently, treatment of latent tuberculosis infection (LTBI) in Australia consists most commonly of a 9-month course of isoniazid (9H). A 3-month course of weekly isoniazid and rifapentine (3HP) has been shown to be as effective as 9 months of daily isoniazid, and associated with less hepatotoxicity; however, rifapentine is not currently available in Australia. Introduction of this regimen would have apparent advantages for people with LTBI in Victoria by safely shortening duration of LTBI therapy...
December 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/29224196/diagnostic-accuracy-of-posterior-cervical-angle-and-cervical-length-in-the-prediction-of-successful-induction-of-labor
#11
Akram M Al-Adwy, Sherin M Sobh, Doaa S Belal, Eman F Omran, Amr Hassan, Ahmed H Saad, Mai M Afifi, Adel M Nada
OBJECTIVE: To determine the accuracy of the posterior cervical angle (PCA) compared with the cervical length and the Bishop score in predicting the outcome of induction of labor (IOL). METHODS: The present prospective observational study included IOL candidates who had their PCA and cervical length assessed by transvaginal ultrasonography and the Bishop score at the Obstetrics and Gynecology Department, Kasr El-Aini Hospital, Cairo University, Cairo, Egypt, between April 1 and July 31, 2017...
December 10, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29224194/establishment-and-evaluation-of-an-indirect-immunofluorescence-assay-for-the-detection-of-salmonid-alphavirus
#12
S Gao, W Shi, Y T Wang, M T Guo, K X Duan, A C Song, G H Lian, Tong Ren, Y J Li, L J Tang, L Sun, M Liu
Salmonid alphaviruses (SAV) severely infects farmed salmonids and rainbow trout. Owing to the recent increase in fish import trade, several SAV-unreported countries, such as China, may face serious threat of this infection. Thus, it is necessary to develop efficient detection methods for the prevention and diagnosis of SAV infection. In this study, we selected a conserved segment of the SAV E1 protein as a target immunogen for the preparation of monoclonal antibodies (mAbs) specific to SAV. A sensitive indirect immunofluorescence (IF) method was developed using 26E9C2 mAb that detected E1 protein and identified subtypes 1, 2 and 5 of SAV...
December 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29224193/screening-of-yeasts-for-the-production-of-2-phenylethanol-rose-aroma-in-organic-waste-based-media
#13
Chreptowicz Karolina, Sternicka Magdalena Katarzyna, Kowalska Patrycja Daria, Mierzejewska Jolanta
In the present study, we isolated twenty eight yeast strains from samples of plant material and fermented food and evaluated the possibility of efficient production of 2-phenylethanol (2-PE) in the organic waste-based media supplemented with L-phenylalanine (L-Phe). We used whey, a by-product from milk processing, as a base for media and either glucose or three by-products from sugar-beet processing as a fermentable carbon source. Ten newly isolated yeast strains were capable of producing over 2 g l-1 2-PE through the L-Phe biotransformation in a batch-mode in standard medium...
December 9, 2017: Letters in Applied Microbiology
https://www.readbyqxmd.com/read/29224189/acute-loss-of-adipose-tissue-derived-adiponectin-triggers-immediate-metabolic-deterioration-in-mice
#14
Jonathan Y Xia, Kai Sun, Chelsea Hepler, Alexandra L Ghaben, Rana K Gupta, Yu A An, William L Holland, Thomas S Morley, Andrew C Adams, Ruth Gordillo, Christine M Kusminski, Philipp E Scherer
AIM/HYPOTHESIS: Adiponectin (APN), a circulating hormone secreted by mature adipocytes, has been extensively studied because it has beneficial metabolic effects. While many studies have focused on the congenital loss of APN and its effects on systemic body glucose and lipid metabolism, little is known about the effects triggered by acute loss of APN in the adult mouse. We anticipated that genetically induced acute depletion of APN in adult mice would have a more profound effect on systemic metabolic health than congenital deletion of Adipoq, the gene encoding APN, with its associated potential for adaptive responses that may mask the phenotypes...
December 9, 2017: Diabetologia
https://www.readbyqxmd.com/read/29224184/experimental-validation-of-the-diffusion-model-based-on-a-slow-response-time-paradigm
#15
Veronika Lerche, Andreas Voss
The diffusion model (Ratcliff, Psychol Rev 85(2):59-108, 1978) is a stochastic model that is applied to response time (RT) data from binary decision tasks. The model is often used to disentangle different cognitive processes. The validity of the diffusion model parameters has, however, rarely been examined. Only few experimental paradigms have been analyzed with those being restricted to fast response time paradigms. This is attributable to a recommendation stated repeatedly in the diffusion model literature to restrict applications to fast RT paradigms (more specifically, to tasks with mean RTs below 1...
December 9, 2017: Psychological Research
https://www.readbyqxmd.com/read/29224165/helper-dependent-chain-reaction-hdcr-for-selective-amplification-of-methylated-dna-sequences
#16
Susan M Mitchell, Keith N Rand, Zheng-Zhou Xu, Thu Ho, Glenn S Brown, Jason P Ross, Peter L Molloy
Over the last few years a number of restriction enzymes that cut DNA only if cytosines within their recognition sequences are methylated have been characterized and become commercially available. Cleavage with these enzymes to release DNA fragments in a methylation-dependent manner can be combined with a novel method of amplification, Helper Dependent Chain Reaction (HDCR), to selectively amplify these fragments. HDCR uses "Helper" oligonucleotides as templates for extension of the free 3' end of target fragments to incorporate tag sequences at the ends of fragments...
2018: Methods in Molecular Biology
https://www.readbyqxmd.com/read/29224135/serum-ferritin-and-obstructive-sleep-apnea-epidemiological-study
#17
Elin H Thorarinsdottir, Erna S Arnardottir, Bryndis Benediktsdottir, Christer Janson, Isleifur Olafsson, Allan I Pack, Thorarinn Gislason, Brendan T Keenan
PURPOSE: Ferritin is an intracellular iron storage protein and a marker of inflammation. Studies have shown that subjects with obstructive sleep apnea (OSA) have higher levels of circulating pro-inflammatory cytokines, but little is known about the association between ferritin and OSA. The aims of the study were to evaluate serum ferritin (S-Ferritin) levels in OSA patients compared to levels in the general population and also examine the effect of obesity level and treatment with positive airway pressure (PAP) on S-Ferritin levels...
December 9, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29224127/defining-and-characterizing-sustained-remission-in-patients-with-rheumatoid-arthritis
#18
Jeffrey R Curtis, Mona Trivedi, Boulos Haraoui, Paul Emery, Grace S Park, David H Collier, Girish A Aras, James Chung
The objective of this study is to characterize stability and clinical features of patients with rheumatoid arthritis (RA) in sustained remission. Combination therapy with methotrexate and tumor necrosis factor inhibitors (TNFi) has increased remission rates in RA but optimal regimens to maintain remission are unknown. We describe Study of Etanercept And Methotrexate in Combination or as Monotherapy in Subjects with Rheumatoid Arthritis (SEAM-RA) and data from a run-in period of longitudinal observation. Patients in Simplified Disease Activity Index (SDAI) remission (score ≤ 3...
December 9, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29224120/spontaneous-cervical-artery-dissection-is-accompanied-by-a-hypercoagulable-state-and-simultaneous-inflammatory-condition
#19
Johann Otto Pelz, Kristian Harms, Michael Metze, Dominik Michalski
BACKGROUND: Spontaneous cervical artery dissections (sCAD) are often preceded by infections. However, existing data about inflammatory parameters remained inconsistent. Remarkably, concurrent information about the coagulation system, whose affection seems also reasonable to cause ischaemic events, are still lacking in sCAD patients. Thus, this study explores the association between the inflammatory and coagulation system in patients with sCAD. METHODS: The parameters leukocyte and thrombocyte count, C-reactive protein, fibrinogen, D-dimer, activated partial thromboplastin time (aPTT) and prothrombin time were extracted from hospital-based medical records of patients (n = 60) with sCAD and compared with those of a control group (n = 97) from a prospective observational stroke study...
December 9, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/29224093/sex-effects-at-the-ramparts-nutrient-and-microbe-mediated-regulation-of-the-immune-metabolic-interface
#20
Nyrie Israelian, Jayne S Danska
The relationships between dietary compounds, derivative metabolites, and host metabolism and immunity are controlled by diverse molecular mechanisms. Essential contributions to these dynamics come from the community of microbes (the microbiome) inhabiting the human digestive tract. The composition and function of the microbiome are shaped by available nutrients, and reciprocally, these organisms produce an as yet poorly defined repertoire of molecules that communicate with the epithelial barrier and the mucosal immune system...
2017: Advances in Experimental Medicine and Biology
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