keyword
MENU ▼
Read by QxMD icon Read
search

S

keyword
https://www.readbyqxmd.com/read/29679946/extensive-depolarization-and-lack-of-recovery-of-leech-retzius-neurons-caused-by-2-4-diaminobutyric-acid
#1
S Spasic, M Stanojevic, J Nesovic Ostojic, S Kovacevic, M Prostran, S Lopicic
In this paper we present, for the first time, a detailed account of electrophysiological effects of 2,4-diaminobutyric acid (2,4-DABA). 2,4-DABA is a neurotoxic non-protein amino acid produced by Cyanobacteria with a possible link to neurodegenerative disorders in animals and humans. Intracellular recordings were performed on Retzius nerve cells of the leech Haemopis sanguisuga using glass microelectrodes filled with 3 mol/L KCl. Our results show that 2,4-DABA is an excitatory amino acid, causing membrane depolarization in a concentration-dependent manner...
March 31, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29679939/semi-volatile-organic-compounds-in-the-snow-of-russian-arctic-islands-archipelago-novaya-zemlya
#2
A T Lebedev, D M Mazur, O V Polyakova, D S Kosyakov, A Yu Kozhevnikov, T B Latkin, I Andreeva Yu, V B Artaev
Environmental contamination of the Arctic has widely been used as a worldwide pollution marker. Various classes of organic pollutants such as pesticides, personal care products, PAHs, flame retardants, biomass burning markers, and many others emerging contaminants have been regularly detected in Arctic samples. Although numerous papers have been published reporting data from the Canadian, Danish, and Norwegian Arctic regions, the environmental situation in Russian Arctic remains mostly underreported. Snow analysis is known to be used for monitoring air pollution in the regions with cold climate in both short-term and long-term studies...
April 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29679924/military-status-and-alcohol-problems-former-soldiers-may-be-at-greater-risk
#3
Bonnie M Vest, D Lynn Homish, Jennifer Fillo, Gregory G Homish
OBJECTIVES: The goal of this study was to explore differences in alcohol problems as a function of military status (current soldier, previous soldier and civilian spouses), and the possible interaction between sex and military status. We hypothesized that 1) soldiers would be at greater risk for alcohol problems than civilian spouses, and 2) former soldiers would be at greater risk compared to current soldiers. METHODS: Data were drawn from Operation: SAFETY, a longitudinal study examining physical and mental health among U...
April 13, 2018: Addictive Behaviors
https://www.readbyqxmd.com/read/29679916/a-novel-framework-for-the-use-of-remote-sensing-for-monitoring-catchments-at-continental-scales
#4
A B Bugnot, M B Lyons, P Scanes, G F Clark, S K Fyfe, A Lewis, E L Johnston
Historical ecology can teach us valuable lessons on the processes and drivers of environmental change that can inform future monitoring priorities and management strategies. Environmental data to study environmental history, however, is often absent or of low quality. Even when studying changes occurring during the last few decades, monitoring efforts are scarce due to logistical and cost limitations, leaving large areas unassessed. The aim of this study is to evaluate the use of estuarine water colour as an indicator of historical environmental change in catchments...
April 18, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29679896/treatment-as-usual-tau-as-a-control-condition-in-trials-of-cognitive-behavioural-based-psychotherapy-for-self-harm-impact-of-content-and-quality-on-outcomes-in-a-systematic-review
#5
REVIEW
Katrina Witt, Daniela Pache de Moraes, Tatiana Taylor Salisbury, Ella Aren S Man, David Gunnell, Philip Hazell, Ellen Townsend, Kees van Heeringen, Keith Hawton
BACKGROUND: Randomized controlled trials (RCTs) are the mainstay of evaluations of the efficacy of psychosocial interventions. In a recent Cochrane systematic review we analysed the efficacy of cognitive behavioural-based psychotherapies compared to treatment as usual (TAU) in adults who self-harm. In this study we examine the content and reporting quality of TAU in these trials and their relationship to outcomes. METHODS: Five electronic databases (CCDANCTR-Studies and References, CENTRAL, MEDLINE, EMBASE, and PsycINFO) were searched for RCTs, indexed between 1 January 1998 and 30 April 2015, of cognitive-behavioural interventions compared to TAU for adults following a recent (within six months) episode of self-harm...
April 4, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29679895/ingredientes-farmac%C3%A3-uticos-activos-potencialmente-inapropiados-en-adultos-mayores-lista-ifaspiam-panel-de-consenso-argentino
#6
Marta M Marzi, Miryam S Pires, Nora B Quaglia
OBJECTIVES: To perform a list agreed by Argentinean experts and adapted to the local context containing potentially inappropriate (PI) medications in old people (OP) usingthe Delphi consensus technique optimized for this subject. METHODS: A preliminary list of potentially inappropriate medications (PIM) was drawn up based on foreign PIM lists and a selective search in the scientific literature. The iterative Delphi process was used to submit the active pharmaceutical ingredients (APIs) of the preliminary PIM list to the panel of Argentinean experts...
April 18, 2018: Value in Health Regional Issues
https://www.readbyqxmd.com/read/29679893/identification-of-homocysteine-suppressive-mitochondrial-etc-complex-genes-and-tissue-expression-profile-novel-hypothesis-establishment
#7
Ramon Cueto, Lixiao Zhang, Hui Min Shan, Xiao Huang, Xinyuan Li, Ya-Feng Li, Jahaira Lopez, William Y Yang, Muriel Lavallee, Catherine Yu, Yong Ji, Xiaofeng Yang, Hong Wang
Hyperhomocysteinemia (HHcy) is an independent risk factor for cardiovascular disease (CVD) which has been implicated in matochondrial (Mt) function impairment. In this study, we characterized Hcy metabolism in mouse tissues by using LC-ESI-MS/MS analysis, established tissue expression profiles for 84 nuclear-encoded Mt electron transport chain complex (nMt-ETC-Com) genes in 20 human and 19 mouse tissues by database mining, and modeled the effect of HHcy on Mt-ETC function. Hcy levels were high in mouse kidney/lung/spleen/liver (24-14 nmol/g tissue) but low in brain/heart (~5 nmol/g)...
April 4, 2018: Redox Biology
https://www.readbyqxmd.com/read/29679892/electric-field-driven-assembly-of-live-bacterial-cell-microarrays-for-rapid-phenotypic-assessment-and-cell-viability-testing
#8
Meenal Goel, Abhishek Verma, Shalini Gupta
Microarray technology to isolate living cells using external fields is a facile way to do phenotypic analysis at the cellular level. We have used alternating current dielectrophoresis (AC-DEP) to drive the assembly of live pathogenic Salmonella typhi (S.typhi) and Escherichia coli (E.coli) bacteria into miniaturized single cell microarrays. The effects of voltage and frequency were optimized to identify the conditions for maximum cell capture which gave an entrapment efficiency of 90% in 60 min. The chip was used for calibration-free estimation of cellular loads in binary mixtures and further applied for rapid and enhanced testing of cell viability in the presence of drug via impedance spectroscopy...
April 7, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29679886/cytotoxicity-of-novel-fluoride-solutions-and-their-influence-on-mineral-loss-from-enamel-exposed-to-a-streptococcus-mutans-biofilm
#9
Thiago Isidro Vieira, João Victor Frazão Câmara, Júlia Gabiroboertz Cardoso, Adílis Kalina Alexandria, Andréa Vaz Braga Pintor, Jaqueline Correia Villaça, Lúcio Mendes Cabral, Maria Teresa Villela Romanos, Andrea Fonseca-Gonçalves, Ana Maria Gondim Valença, Lucianne Cople Maia
OBJECTIVE: This study evaluated the cytotoxicity, antimicrobial activity and in vitro influence of new fluoridated nanocomplexes on dental demineralization. DESIGN: The nanocomplexes hydroxypropyl-β-cyclodextrin with 1% titanium tetrafluoride (TiF4 ) and γ-cyclodextrin with TiF4 were compared to a positive control (TiF4 ), a blank control (without treatment) and negative controls (hydroxypropyl-β-cyclodextrin, γ-cyclodextrin, deionized water), following 12- and 72-hour complexation periods...
April 13, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29679872/maize-productivity-heavy-metals-uptake-and-their-availability-in-contaminated-clay-and-sandy-alkaline-soils-as-affected-by-inorganic-and-organic-amendments
#10
Mahmoud F Seleiman, Ahmed M S Kheir
Contamination of arid and semi-arid ecosystems by toxic heavy metals is a serious concern due to its impact on growth and productivity of crop and health risk through food chain. Therefore, the aims of this investigation were to study the impact of inorganic (i.e. nano hydroxyapatite, NHA and polyacrylamide, PAM) and organic (i.e. sugar beet factory lime, SBFL and biochar, BI) soil amendments on maize productivity grown in contaminated silty clay (i.e. fluvial, lacustrine) and sandy (i.e. marine) alkaline soils...
April 15, 2018: Chemosphere
https://www.readbyqxmd.com/read/29679865/generation-and-characterization-of-hagfish-variable-lymphocyte-receptor-b-against-glycoprotein-of-viral-hemorrhagic-septicemia-virus-vhsv
#11
Jung Seok Lee, Jaesung Kim, Se Pyeong Im, Si Won Kim, Jassy Mary S Lazarte, Jae Wook Jung, Tae Won Gong, Young Rim Kim, Jeong Ho Lee, Hyoung Jun Kim, Tae Sung Jung
Variable lymphocyte receptors B (VLRBs) are non-immunoglobulin components of the humoral immune system in jawless vertebrates including hagfish (Eptatretus burgeri) and lamprey (Petromyzon marinus). Hagfish VLRBs consist of leucine rich repeat (LRR) modules with a superhydrophobic C-terminal tail, the latter of which leads to extremely low expression levels in recombinant protein technology. Here, we present an artificially oligomerized VLRB (arVLRB) that conjugates via the C4bp oligomerization domain derived from human C4b-binding protein (hC4bp) rather than the superhydrophobic tail...
April 18, 2018: Molecular Immunology
https://www.readbyqxmd.com/read/29679864/computational-insights-into-%C3%AE-site-amyloid-precursor-protein-enzyme-1-bace1-inhibition-by-tanshinones-and-salvianolic-acids-from-salvia-miltiorrhiza-via-molecular-docking-simulations
#12
Ting Yu, Pradeep Paudel, Su Hui Seong, Jeong Ah Kim, Hyun Ah Jung, Jae Sue Choi
The rhizome of Salvia miltiorrhiza has emerged as a rich source of natural therapeutic agents, and its several compounds are supposed to exhibit favorable effects on Alzheimer's disease (AD). The present work investigate the anti-AD potentials of 12 tanshinones, three salvianolic acids and three caffeic acid derivatives from S. miltiorrhiza via the inhibition of β-site amyloid precursor protein cleaving enzyme 1 (BACE1). Among the tested compounds, deoxyneocryptotanshinone (1), salvianolic acid A (13) and salvianolic acid C (15) displayed good inhibitory effect on BACE1 with IC50 values of 11...
April 13, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29679861/hygiene-auditing-in-mass-catering-a-4-year-study-in-a-university-canteen
#13
A Osimani, V Milanović, L Aquilanti, S Polverigiani, C Garofalo, F Clementi
OBJECTIVES: The outcomes of hygiene audits carried out two times per year were used to determine the correct execution of the procedures foreseen by the Hazard Analysis and Critical Control Points (HACCP) plan over 4 years (2013-2016) in a university canteen producing about 1200 meals a day. STUDY DESIGN: Critical analysis of hygiene audits. METHODS: Hygiene audits were carried out on the basis of a checklist divided into seven main items and subitems that covered all the production areas of the canteen...
April 18, 2018: Public Health
https://www.readbyqxmd.com/read/29679854/thymol-attenuates-the-worsening-of-atopic-dermatitis-induced-by-staphylococcus-aureus-membrane-vesicles
#14
Hyo Il Kwon, Na Hee Jeong, So Hyun Jun, Joo Hee Son, Shukho Kim, Hyejin Jeon, Sun Chul Kang, Sang Hyun Kim, Je Chul Lee
Staphylococcus aureus membrane vesicles (MVs) aggravate atopic dermatitis (AD) through the delivery of bacterial effector molecules to host cells and the stimulation of inflammatory responses. This study investigated the inhibitory effect of thymol, a phenolic monoterpene found in essential oils derived from plants, on the worsening of AD induced by S. aureus MVs both in vitro and in vivo. The sub-minimal inhibitory concentrations of thymol disrupted S. aureus MVs. Intact S. aureus MVs induced the expression of pro-inflammatory cytokine (interleukin (IL)-1β, IL-6, and tumor necrosis factor-α) and chemokine (IL-8 and monocyte chemoattractant protein-1) genes in cultured keratinocytes, whereas thymol-treated S...
April 18, 2018: International Immunopharmacology
https://www.readbyqxmd.com/read/29679833/the-contribution-of-cattle-urine-and-dung-to-nitrous-oxide-emissions-quantification-of-country-specific-emission-factors-and-implications-for-national-inventories
#15
D R Chadwick, L M Cardenas, M S Dhanoa, N Donovan, T Misselbrook, J R Williams, R E Thorman, K L McGeough, C J Watson, M Bell, S G Anthony, R M Rees
Urine patches and dung pats from grazing livestock create hotspots for production and emission of the greenhouse gas, nitrous oxide (N2 O), and represent a large proportion of total N2 O emissions in many national agricultural greenhouse gas inventories. As such, there is much interest in developing country specific N2 O emission factors (EFs) for excretal nitrogen (EF3, pasture, range and paddock) deposited during gazing. The aims of this study were to generate separate N2 O emissions data for cattle derived urine and dung, to provide an evidence base for the generation of a country specific EF for the UK from this nitrogen source...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679829/fulfilling-spawning-flow-requirements-for-potamodromous-cyprinids-in-a-restored-river-segment
#16
Isabel Boavida, Joaquim B Jesus, Vítor Pereira, Cátia Santos, Marisa Lopes, Rui M V Cortes
The Baixo Sabor hydroelectric scheme was recently constructed (began operating in 2015), blocking fish migration immediately at the river mouth. As a compensation measure for spawning habitat loss the Vilariça River which confluences with Sabor River, immediately downstream from the Baixo Sabor scheme, was chosen for rehabilitation site as an attempt to replace the spawning grounds lost in Sabor River for the potamodromous cyprinid Iberian barbel (Luciobarbus bocagei). Restoration activities included: placement of submerged weirs with fish ramps to increase the lotic/lentic sequence, bank reinforcement, boulder placement and river water profile increase...
April 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29679818/the-2014-integrated-field-exercise-of-the-comprehensive-nuclear-test-ban-treaty-revisited-the-case-for-data-fusion
#17
Jonathan L Burnett, Harry S Miley, Theodore W Bowyer, Ian M Cameron
The International Monitoring System of the Preparatory Commission for the Comprehensive Nuclear-Test-Ban Treaty Organization (CTBTO) uses a global network of radionuclide monitoring stations to detect evidence of a nuclear explosion. The two radionuclide technologies employed-particulate and noble gas (radioxenon) detection-have applications for data fusion to improve detection of a nuclear explosion. Using the hypothetical 0.5 kT nuclear explosive test scenario of the CTBTO 2014 Integrated Field Exercise, the intrinsic relationship between particulate and noble gas signatures has been examined...
April 18, 2018: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/29679816/poor-mental-health-among-low-income-women-in-the-u-s-the-roles-of-adverse-childhood-and-adult-experiences
#18
Joshua P Mersky, Colleen E Janczewski, Jenna C Nitkowski
RATIONALE: It is well established that exposure to a greater number of adverse childhood experiences (ACEs) increases the risk of poor physical and mental health outcomes. Given the predictive validity of ACE scores and other cumulative risk metrics, a similar measurement approach may advance the study of risk in adulthood. OBJECTIVE: We examined the prevalence and interrelations of 10 adverse adult experiences, including household events such as intimate partner violence and extrafamilial events such as crime victimization...
April 14, 2018: Social Science & Medicine
https://www.readbyqxmd.com/read/29679811/hepatitis-c-care-continuum-and-associated-barriers-among-people-who-inject-drugs-in-chennai-india
#19
Eshan U Patel, Sunil S Solomon, Allison M Mcfall, Aylur K Srikrishnan, Amrose Pradeep, Paneerselvam Nandagopal, Oliver Laeyendecker, Aaron A R Tobian, David L Thomas, Mark S Sulkowski, M Suresh Kumar, Shruti H Mehta
BACKGROUND: Little is known regarding barriers to hepatitis C virus (HCV) treatment among people who inject drugs (PWID) in low-resource settings, particularly in the era of direct-acting antiviral therapies. METHODS: Between March, 2015-August, 2016, a cross-sectional survey was administered to community-based PWID in Chennai, India to examine the HCV care continuum and associated barriers. Adjusted prevalence ratios (APR) were estimated by multivariable Poisson regression with robust variance...
April 18, 2018: International Journal on Drug Policy
https://www.readbyqxmd.com/read/29679792/metacognitive-self-reflectivity-moderates-the-relationship-between-distress-tolerance-and-empathy-in-schizophrenia
#20
Kelsey A Bonfils, Kyle S Minor, Bethany L Leonhardt, Paul H Lysaker
Deficits in empathy seen in schizophrenia are thought to play a major role in the social dysfunction seen in the disorder. However, little work has investigated potential determinants of empathic deficits. This study aimed to fill that gap by examining the effects of two variables on empathy - distress tolerance and metacognitive self-reflectivity. Fifty-four people with schizophrenia-spectrum disorders receiving services at an urban VA or community mental health center were assessed for empathy, metacognition, and distress tolerance...
April 13, 2018: Psychiatry Research
keyword
keyword
57753
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"