Nina Babel, Moritz Anft, Arturo Blazquez-Navarro, Adrian A N Doevelaar, Felix S Seibert, Frederic Bauer, Benjamin J Rohn, Bodo Hoelzer, Constantin J Thieme, Toralf Roch, Toni L Meister, Stephanie Pfaender, Eike Steinmann, Ulf Dittmer, Peter Schenker, Kerstin Amann, Richard Viebahn, Ulrik Stervbo, Timm H Westhoff
The optimal management in transplant recipients with COVID-19 remains uncertain. The main concern is the ability of immunosuppressed patients to generate sufficient immunity for antiviral protection. Here, we report on immune monitoring facilitating a successful outcome of severe SARS-CoV-2-associated pneumonia, meningoencephalitis, gastroenteritis and acute kidney and pancreas graft failure in a pancreas-kidney transplant recipient. Despite the very low numbers of circulating B-, NK-, and T-cells identified in follow up, a strong SARS-CoV-2 reactive T-cell response was observed...
August 10, 2020: American Journal of Transplantation