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https://www.readbyqxmd.com/read/27493813/extranodal-nk-t-cell-lymphoma-causing-cardiorespiratory-failure
#1
Yiting Li, Ivan Damjanov
Extranodal NK/T cell lymphoma is an uncommon malignancy usually involving the sinonasal area. We report an unusual case of extranodal NK/T cell lymphoma diagnosed in a 62-year-old Caucasian male who died of progressive cardiorespiratory failure but had no clinically detectable upper respiratory system lesions. The initial diagnosis was made cytologically on a sample of pericardial fluid that contained neoplastic lymphoid cells. These cells were positive for CD2, cytoplasmic CD3, and Epstein-Barr virus and negative for CD56...
2016: Case Reports in Hematology
https://www.readbyqxmd.com/read/26489735/innate-and-adaptive-immunity-to-human-beta-cell-lines-implications-for-beta-cell-therapy
#2
Cornelis van der Torren, Arnaud Zaldumbide, Dave L Roelen, Gaby Duinkerken, Simone H Brand-Schaaf, Mark Peakman, Paul Czernichow, Philippe Ravassard, Raphael Scharfmann, Bart O Roep
AIMS/HYPOTHESIS: Genetically engineered human beta cell lines provide a novel source of human beta cells to study metabolism, pharmacology and beta cell replacement therapy. Since the immune system is essentially involved in beta cell destruction in type 1 diabetes and after beta cell transplantation, we investigated the interaction of human beta cell lineswith the immune system to resolve their potential for immune intervention protocol studies. METHODS: Human pancreatic beta cell lines (EndoC-βH1 and ECi50) generated by targeted oncogenesis in fetal pancreas were assessed for viability after innate and adaptive immune challenges...
January 2016: Diabetologia
https://www.readbyqxmd.com/read/26244831/depletion-of-il-2-receptor-%C3%AE-positive-cells-protects-from-diabetes-in-non-obese-diabetic-mice
#3
Hanna Brauner, Håkan T Hall, Malin Flodström-Tullberg, Klas Kärre, Petter Höglund, Sofia Johansson
The destruction of β-cells in type 1 diabetes (T1D) progresses silently until only a minor fraction of the β-cells remain. A late acting therapy leading to the prevention of further β-cell killing would therefore be desirable. CD122, the β chain of the interleukin-2 receptor, is highly expressed on natural killer (NK) cells and on a subpopulation of CD8 T cells. In this study, we have treated non-obese diabetic (NOD) mice with a depleting antibody against CD122. The treatment protected from diabetes, even when initiated just before disease onset...
February 2016: Immunology and Cell Biology
https://www.readbyqxmd.com/read/26170385/innate-response-to-human-cancer-cells-with-or-without-il-2-receptor-common-%C3%AE-chain-function-in-nod-background-mice-lacking-adaptive-immunity
#4
Chiyoko Nishime, Kenji Kawai, Takehiro Yamamoto, Ikumi Katano, Makoto Monnai, Nobuhito Goda, Tomoko Mizushima, Hiroshi Suemizu, Masato Nakamura, Mitsuru Murata, Makoto Suematsu, Masatoshi Wakui
Immunodeficient hosts exhibit high acceptance of xenogeneic or neoplastic cells mainly due to lack of adaptive immunity, although it still remains to be elucidated how innate response affects the engraftment. IL-2R common γ-chain (IL-2Rγc) signaling is required for development of NK cells and a subset of dendritic cells producing IFN-γ. To better understand innate response in the absence of adaptive immunity, we examined amounts of metastatic foci in the livers after intrasplenic transfer of human colon cancer HCT116 cells into NOD/SCID versus NOD/SCID/IL-2Rγc (null) (NOG) hosts...
August 15, 2015: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/25854920/senescent-cells-communicate-via-intercellular-protein-transfer
#5
Anat Biran, Meirav Perelmutter, Hilah Gal, Dominick G A Burton, Yossi Ovadya, Ezra Vadai, Tamar Geiger, Valery Krizhanovsky
Mammalian cells mostly rely on extracellular molecules to transfer signals to other cells. However, in stress conditions, more robust mechanisms might be necessary to facilitate cell-cell communications. Cellular senescence, a stress response associated with permanent exit from the cell cycle and the development of an immunogenic phenotype, limits both tumorigenesis and tissue damage. Paradoxically, the long-term presence of senescent cells can promote tissue damage and aging within their microenvironment. Soluble factors secreted from senescent cells mediate some of these cell-nonautonomous effects...
April 15, 2015: Genes & Development
https://www.readbyqxmd.com/read/25638348/pancreas-metastasization-of-nasal-nk-t-cell-lymphoma-a-case-report
#6
Chong Zhou, Xiangzhao Bu, Xiangyang Li, Ling Liu, Xiaomei Xie, Shichao Zhuo, Haitao Yin
We report here a case of nasal natural killer/T-cell lymphoma with metastasization into the pancreas. A 43-year-old Chinese female patient presented with right nasal obstruction and purulent rhinorrhea that lasted for the past half year and worsened gradually despite antibiotic medical treatment. Physical examination revealed a mass in the right nasal cavity and an enlarged lymph node in the right submandibular region. A PET/CT scan and immunostaining of the resectate led to a diagnosis of nasal natural killer/T-cell lymphoma, clinical stage IIE, and the International Prognostic Index score of 1...
September 2015: Cell Biochemistry and Biophysics
https://www.readbyqxmd.com/read/25333972/role-of-nkg2d-in-obesity-induced-adipose-tissue-inflammation-and-insulin-resistance
#7
Jun-Jae Chung, Mary A Markiewicz, Bojan Polić, Andrey S Shaw
The early events that initiate inflammation in the adipose tissue during obesity are not well defined. It is unclear whether the recruitment of CD8 T cells to the adipose tissue during onset of obesity occurs through antigen-dependent or -independent processes. We have previously shown that interaction between NKG2D (natural-killer group 2, member D) and its ligand Rae-1ε is sufficient to recruit cytotoxic T lymphocytes to the pancreas and induce insulitis. Here, we tested whether NKG2D-NKG2D ligand interaction is also involved in obesity-induced adipose tissue inflammation and insulin resistance...
2014: PloS One
https://www.readbyqxmd.com/read/25043259/dietary-gluten-increases-natural-killer-cell-cytotoxicity-and-cytokine-secretion
#8
Jesper Larsen, Morten Dall, Julie Christine Antvorskov, Christian Weile, Kåre Engkilde, Knud Josefsen, Karsten Buschard
Dietary gluten influences the development of type 1 diabetes in nonobese diabetic (NOD) mice and biobreeding rats, and has been shown to influence a wide range of immunological factors in the pancreas and gut. In the present study, the effects of gluten on NK cells were studied in vitro and in vivo. We demonstrated that gliadin increased direct cytotoxicity and IFN-γ secretion from murine splenocytes and NK cells toward the pancreatic beta-cell line MIN6 cells. Additionally, stimulation of MIN6 cells led to a significantly increased proportion of degranulating C57BL/6 CD107a(+) NK cells...
October 2014: European Journal of Immunology
https://www.readbyqxmd.com/read/25022955/il-32%C3%AE-overexpression-accelerates-streptozotocin-stz-induced-type-1-diabetes
#9
Hyunjhung Jhun, Jida Choi, Jaewoo Hong, Siyoung Lee, Areum Kwak, Eunsom Kim, Seunghyun Jo, Soyoon Ryoo, Yoojung Lim, Do-Young Yoon, Jin Tae Hong, Tae Sung Kim, Youngmin Lee, Keeho Song, Soohyun Kim
Interleukin-32 (IL-32) is a cytokine produced by T lymphocytes, natural killer (NK) cells, monocytes and epithelial cells. There are five splicing variants (α, β, γ, δ, and ε) and IL-32γ is the most active isoform. We generated human IL-32γ transgenic (IL-32γ TG) mice, displaying a high level of IL-32γ expression in the pancreas. We investigated the effect of IL-32γ on streptozotocin (STZ)-induced type 1 diabetes model using IL-32γ TG mice. After a suboptimal diabetogenic dose of STZ administration, IL-32γ TG mice showed significantly increased blood glucose level comparing with that of wild type (WT) mice at day 5...
September 2014: Cytokine
https://www.readbyqxmd.com/read/24795987/administration-of-sulfatide-to-ameliorate-type-i-diabetes-in-non-obese-diabetic-mice
#10
S Rhost, L Lofbom, J -E Mansson, A Lehuen, M Blomqvist, S L Cardell
The endogenous glycosphingolipid sulfatide is a ligand for CD1d-restricted type II natural killer T (NKT) lymphocytes. Through the action of these cells,sulfatide treatment has been shown to modulate the immune response in mouse models for autoimmune diseases, infections and tumour immunity. Sulfatide exists naturally in different organs including the pancreas, where sulfatide colocalizes with insulin within the Langerhans islet b-cells, targets for the immune destruction in type 1 diabetes (T1D). Human T1D patients, but not patients with type 2 diabetes nor healthy individuals, have autoantibodies against sulfatide in serum, suggesting that sulfatide induces an immune response in the natural course of T1D in humans...
April 2014: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/24693199/cancer-incidence-and-novel-therapies-developed-in-japan
#11
M Iwasaki
According to the ministry of Health, Labour and welfare of Japan, Cancer has been the leading cause of death in Japan since 1981. ([1]) As per the data in 2010, in Japan, one in every three deaths was due to cancer. ([2]) The Japanese Government has introduced so far, three terms of 10 years strategies for Cancer control since 1984 till date. The budget allocated for cancer control in 2009 was 52.5 billion yen in Japan. ([3]) Lung is the leading site for cancer in both males and females in Japan. In males, following the lung, stomach, liver, colon and pancreas are other leading sites while in the females, stomach, colon, pancreas and breast are the other leading sites...
2012: Journal of Stem Cells & Regenerative Medicine
https://www.readbyqxmd.com/read/24673402/a-gluten-free-diet-lowers-nkg2d-and-ligand-expression-in-balb-c-and-non-obese-diabetic-nod-mice
#12
E H Adlercreutz, C Weile, J Larsen, K Engkilde, D Agardh, K Buschard, J C Antvorskov
The interplay between diet and immune parameters which could affect type 1 diabetes (T1D) pathogenesis is not sufficiently clarified. Intestinal up-regulation of the activating receptor natural killer group 2D (NKG2D) (CD314) and its ligands is a hallmark of coeliac disease. However, the direct effect of gluten on NKG2D expression is not known. We studied, by fluorescence activated cell sorter (lymphoid tissues) and reverse transcription-quantitative polymerase chain reaction (intestine and pancreatic islets), if a gluten-free diet (GF diet) from 4 weeks of age or a gluten-free diet introduced in breeding pairs (SGF diet), induced changes in NKG2D expression on DX5(+) (CD49b) natural killer (NK) cells, CD8(+) T cells and in intestinal and islet levels of NKG2D and ligands in BALB/c and non-obese diabetic (NOD) mice...
August 2014: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/24608924/influence-of-interferon-alpha-combined-with-chemo-radio-therapy-on-immunological-parameters-in-pancreatic-adenocarcinoma
#13
RANDOMIZED CONTROLLED TRIAL
Svetlana Karakhanova, Beate Mosl, Sabine Harig, Katharina von Ahn, Jasmin Fritz, Jan Schmidt, Dirk Jäger, Jens Werner, Alexandr V Bazhin
Prognosis of patients with carcinoma of the exocrine pancreas is particularly poor. A combination of chemotherapy with immunotherapy could be an option for treatment of pancreatic cancer. The aim of this study was to perform an immunomonitoring of 17 patients with pancreatic cancer from the CapRI-2 study, and tumor-bearing mice treated with combination of chemo (radio) therapies with interferon-2α. Low doses of interferon-2α led to a decrease in total leukocyte and an increase in monocyte counts. Furthermore, we observed a positive effect of interferon-2α therapy on the dendritic cells and NK (natural killer) cell activation immediately after the first injection...
2014: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/24497788/breast-metastases-from-extramammary-malignancies-typical-and-atypical-ultrasound-features
#14
Sung Hee Mun, Eun Young Ko, Boo-Kyung Han, Jung Hee Shin, Suk Jung Kim, Eun Yoon Cho
Breast metastases from extramammary malignancies are uncommon. The most common sources are lymphomas/leukemias and melanomas. Some of the less common sources include carcinomas of the lung, ovary, and stomach, and infrequently, carcinoid tumors, hypernephromas, carcinomas of the liver, tonsil, pleura, pancreas, cervix, perineum, endometrium and bladder. Breast metastases from extramammary malignancies have both hematogenous and lymphatic routes. According to their routes, there are common radiological features of metastatic diseases of the breast, but the features are not specific for metastases...
January 2014: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
https://www.readbyqxmd.com/read/24419974/extranodal-lymphoma-with-peripheral-nervous-system-involvement-in-a-dog
#15
Hiroshi Ueno, Kenjiro Miyoshi, Sho Fukui, Yumi Kondo, Kazuya Matsuda, Tsuyoshi Uchide
An 8-year-old neutered female Cavalier King Charles spaniel was evaluated for progressing right forelimb lameness. Magnetic resonance imaging revealed that the right-side radial nerves and the caudal brachial plexus were swollen. The histological and molecular biological diagnosis by partial biopsy of the C8 spinal nerve was T-cell lymphoma. Coadministration of lomustine and irradiation was started. However, this therapy was ineffective. At necropsy, neoplastic tissues were seen extending into the subarachnoid space of the spinal cord, liver, pancreas and kidneys as gross findings...
May 2014: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/24009765/the-expression-of-the-beta-cell-derived-autoimmune-ligand-for-the-killer-receptor-nkp46-is-attenuated-in-type-2-diabetes
#16
Chamutal Gur, Jonatan Enk, Efraim Weitman, Etty Bachar, Yaron Suissa, Guy Cohen, Rachel Ben-Haroush Schyr, Helena Sabanay, Elad Horwitz, Benjamin Glaser, Yuval Dor, Ariel Pribluda, Jacob H Hanna, Gill Leibowitz, Ofer Mandelboim
NK cells rapidly kill tumor cells, virus infected cells and even self cells. This is mediated via killer receptors, among which NKp46 (NCR1 in mice) is prominent. We have recently demonstrated that in type 1 diabetes (T1D) NK cells accumulate in the diseased pancreas and that they manifest a hyporesponsive phenotype. In addition, we found that NKp46 recognizes an unknown ligand expressed by beta cells derived from humans and mice and that blocking of NKp46 activity prevented diabetes development. Here we investigated the properties of the unknown NKp46 ligand...
2013: PloS One
https://www.readbyqxmd.com/read/23717394/chronic-alcohol-ingestion-increases-mortality-and-organ-injury-in-a-murine-model-of-septic-peritonitis
#17
Benyam P Yoseph, Elise Breed, Christian E Overgaard, Christina J Ward, Zhe Liang, Maylene E Wagener, Daniel R Lexcen, Elizabeth R Lusczek, Greg J Beilman, Eileen M Burd, Alton B Farris, David M Guidot, Michael Koval, Mandy L Ford, Craig M Coopersmith
BACKGROUND: Patients admitted to the intensive care unit with alcohol use disorders have increased morbidity and mortality. The purpose of this study was to determine how chronic alcohol ingestion alters the host response to sepsis in mice. METHODS: Mice were randomized to receive either alcohol or water for 12 weeks and then subjected to cecal ligation and puncture. Mice were sacrificed 24 hours post-operatively or followed seven days for survival. RESULTS: Septic alcohol-fed mice had a significantly higher mortality than septic water-fed mice (74% vs...
2013: PloS One
https://www.readbyqxmd.com/read/23670972/limitations-of-il-2-and-rapamycin-in-immunotherapy-of-type-1-diabetes
#18
Audrey Baeyens, Louis Pérol, Gwladys Fourcade, Nicolas Cagnard, Wassila Carpentier, Janine Woytschak, Onur Boyman, Agnès Hartemann, Eliane Piaggio
Administration of low-dose interleukin-2 (IL-2) alone or combined with rapamycin (RAPA) prevents hyperglycemia in NOD mice. Also, low-dose IL-2 cures recent-onset type 1 diabetes (T1D) in NOD mice, partially by boosting pancreatic regulatory T cells (Treg cells). These approaches are currently being evaluated in humans. Our objective was to study the effect of higher IL-2 doses (250,000-500,000 IU daily) as well as low-dose IL-2 (25,000 IU daily) and RAPA (1 mg/kg daily) (RAPA/IL-2) combination. We show that, despite further boosting of Treg cells, high doses of IL-2 rapidly precipitated T1D in prediabetic female and male mice and increased myeloid cells in the pancreas...
September 2013: Diabetes
https://www.readbyqxmd.com/read/23580887/immunological-characteristics-of-mesenchymal-stem-cells
#19
Cíntia de Vasconcellos Machado, Paloma Dias da Silva Telles, Ivana Lucia Oliveira Nascimento
Although bone marrow is the main source, mesenchymal stem cells have already been isolated from various other tissues, such as the liver, pancreas, adipose tissue, peripheral blood and dental pulp. These plastic adherent cells are morphologically similar to fibroblasts and have a high proliferative potential. This special group of cells possesses two essential characteristics: self-renewal and differentiation, with appropriate stimuli, into various cell types. Mesenchymal stem cells are considered immunologically privileged, since they do not express costimulatory molecules, required for complete T cell activation, on their surface...
2013: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/23426534/first-report-of-primary-pancreatic-natural-killer-t-cell-nasal-type-lymphoma
#20
W Liu, R Hua, J-F Zhang, Y-M Huo, D-J Liu, Y-W Sun
BACKGROUND: Primary pancreatic lymphoma (PPL) is an extremely rare form of extranodal malignant lymphoma and pancreatic tumour. Natural killer/T-cell lymphoma is an aggressive rare form extranodal lymphoma with a predilection for the nasal cavity/nasopharynx, it can arise in other organs such as skin, testicles, spleen, adrenal, or GI tract, but the initial presentation of our patient in the pancreas is unreported. CASE PRESENTATION: We present a case of primary pancreatic natural killer/T-cell nasal type lymphoma in a 62-year-old man...
February 2013: European Review for Medical and Pharmacological Sciences
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