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NK cells and pancreas microenvironment

Anat Biran, Meirav Perelmutter, Hilah Gal, Dominick G A Burton, Yossi Ovadya, Ezra Vadai, Tamar Geiger, Valery Krizhanovsky
Mammalian cells mostly rely on extracellular molecules to transfer signals to other cells. However, in stress conditions, more robust mechanisms might be necessary to facilitate cell-cell communications. Cellular senescence, a stress response associated with permanent exit from the cell cycle and the development of an immunogenic phenotype, limits both tumorigenesis and tissue damage. Paradoxically, the long-term presence of senescent cells can promote tissue damage and aging within their microenvironment. Soluble factors secreted from senescent cells mediate some of these cell-nonautonomous effects...
April 15, 2015: Genes & Development
Fu-Dong Shi, Hans-Gustaf Ljunggren, Antonio La Cava, Luc Van Kaer
Natural killer (NK) cells can be swiftly mobilized by danger signals and are among the earliest arrivals at target organs of disease. However, the role of NK cells in mounting inflammatory responses is often complex and sometimes paradoxical. Here, we examine the divergent phenotypic and functional features of NK cells, as deduced largely from experimental mouse models of pathophysiological responses in the liver, mucosal tissues, uterus, pancreas, joints and brain. Moreover, we discuss how organ-specific factors, the local microenvironment and unique cellular interactions may influence the organ-specific properties of NK cells...
October 2011: Nature Reviews. Immunology
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