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https://www.readbyqxmd.com/read/29031232/does-prior-domain-specific-content-knowledge-influence-students-recall-of-arguments-surrounding-interdisciplinary-topics
#1
Hiemke K Schmidt, Martin Rothgangel, Dietmar Grube
Awareness of various arguments can help interactants present opinions, stress points, and build counterarguments during discussions. At school, some topics are taught in a way that students learn to accumulate knowledge and gather arguments, and later employ them during debates. Prior knowledge may facilitate recalling information on well structured, fact-based topics, but does it facilitate recalling arguments during discussions on complex, interdisciplinary topics? We assessed the prior knowledge in domains related to a bioethical topic of 277 students from Germany (approximately 15 years old), their interest in the topic, and their general knowledge...
October 11, 2017: Journal of Adolescence
https://www.readbyqxmd.com/read/29031224/direct-one-pot-synthesis-of-cinnamaldehyde-immobilized-on-gold-nanoparticles-and-their-antibiofilm-properties
#2
Mohankandhasamy Ramasamy, Jin-Hyung Lee, Jintae Lee
The objective of the present study was to develop a one-pot strategy to synthesis gold nanoparticle complexes using cinnamaldehyde, a potent antibiofilm agent which in its free form, exhibits high volatility and unstable nature. Hence, we developed cinnamaldehyde gold nanoparticles (CGNPs) in a single step to overcome the limitations of free cinnamaldehyde. Furthermore, reduction abilities of cinnamaldehyde under different experimental conditions, that is, varying precursor concentrations of cinnamaldehyde and gold, metal salts, pH, temperature, and light sources, were investigated...
October 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29031223/enhanced-antibacterial-activity-and-biocompatibility-of-zinc-incorporated-organic-inorganic-nanocomposite-coatings-via-electrophoretic-deposition
#3
Pin Huang, Kena Ma, Xinjie Cai, Dan Huang, Xu Yang, Jiabing Ran, Fushi Wang, Tao Jiang
Increased use of reconstruction procedures in orthopedics has improved the life of patients undergoing surgery. However, surgical site infection remains a major challenge. Efforts were made to fabricate antibacterial surfaces with good biocompatibility. This present study aimed to fabricate zinc-incorporated chitosan/gelatin (CS/G) nanocomposite coatings on the titanium substrates via electrophoretic deposition (EPD). Physicochemical characterization confirmed that zinc was successfully deposited in a metallic oxide/salt complex status...
October 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29031213/impairment-of-heart-rhythm-complexity-in-patients-with-drug-resistant-epilepsy-an-assessment-with-multiscale-entropy-analysis
#4
Hongyun Liu, Zhao Yang, Fangang Meng, Yuguang Guan, Yanshan Ma, Shuli Liang, Jiuluan Lin, Longsheng Pan, Mingming Zhao, Wei Qu, Hongwei Hao, Guoming Luan, Jianguo Zhang, Luming Li
OBJECTIVE: Epilepsy and seizures can have dramatic effects on the cardiac function. The aim of this study was to investigate the heart rhythm complexity in patients with drug-resistant epilepsy (DRE). METHODS: Ambulatory 24-h electrocardiograms (ECG) from 70 DRE patients and 50 healthy control subjects were analyzed using conventional heart rate variability (HRV) and multiscale entropy (MSE) methods The variation of complexity indices (CI), which was calculated from MSE profile, was determined...
October 5, 2017: Epilepsy Research
https://www.readbyqxmd.com/read/29031197/mitochondrial-dysfunction-is-responsible-for-fatty-acid-synthase-inhibition-induced-apoptosis-in-breast-cancer-cells-by-pdpamn
#5
Qiang Wang, Xia Du, Bingjie Zhou, Jing Li, Wenlong Lu, Qiuyun Chen, Jing Gao
Targeting cellular metabolism is becoming a hallmark to overcome drug resistance in breast cancer treatment. Activation of fatty acid synthase (FASN) has been shown to promote breast cancer cell growth. However, there is no concrete report underlying the mechanism associated with mitochondrial dysfunction in relation to fatty acid synthase inhibition-induced apoptosis in breast cancer cells. The current study is aimed at exploring the effect of the novel manganese (Mn) complex, labeled as PdpaMn, on lipid metabolism and mitochondrial function in breast cancer cells...
October 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29031187/modelling-transitions-in-urban-water-systems
#6
W Rauch, C Urich, P M Bach, B C Rogers, F J de Haan, R R Brown, M Mair, D T McCarthy, M Kleidorfer, R Sitzenfrei, A Deletic
Long term planning of urban water infrastructure requires acknowledgement that transitions in the water system are driven by changes in the urban environment, as well as societal dynamics. Inherent to the complexity of these underlying processes is that the dynamics of a system's evolution cannot be explained by linear cause-effect relationships and cannot be predicted under narrow sets of assumptions. Planning therefore needs to consider the functional behaviour and performance of integrated flexible infrastructure systems under a wide range of future conditions...
September 22, 2017: Water Research
https://www.readbyqxmd.com/read/29031180/design-of-silk-proteins-with-increased-heme-binding-capacity-and-fabrication-of-silk-heme-materials
#7
Trevor D Rapson, Jian-Wei Liu, Alagacone Sriskantha, Mustafa Musameh, Christopher J Dunn, Jeffrey S Church, Andrea Woodhead, Andrew C Warden, Mark J Riley, Jeffrey R Harmer, Christopher J Noble, Tara D Sutherland
In our previous studies, heme was bound into honeybee silk to generate materials that could function as nitric oxide sensors or as recoverable heterogeneous biocatalysts. In this study, we sought to increase the heme-binding capacity of the silk protein by firstly redesigning the heme binding site to contain histidine as the coordinating residue and secondly, by adding multiple histidine residues within the core of the coiled coil core region of the modified silk protein. We used detergent and a protein denaturant to confirm the importance of the helical structure of the silk for heme coordination...
September 4, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29031179/carbosilane-metallodendrimers-based-on-copper-ii-complexes-synthesis-epr-characterization-and-anticancer-activity
#8
Natalia Sanz Del Olmo, Marta Maroto-Díaz, Rafael Gómez, Paula Ortega, Michela Cangiotti, M Francesca Ottaviani, F Javier de la Mata
A series of new organometallic carbosilane dendrimers functionalized with Copper(II) complex on the surface were synthesized and characterized as potential anticancer agents. These metallodendrimers were synthesized through the reaction of dendritic ligands containing N,N- and N,O- donor atoms able to act as chelating agents with CuCl2 as metallic ion precursor. The structural characterization of these complexes was addressed through the use of different analytical and spectroscopical techniques. Particularly, an electron paramagnetic resonance study was performed to corroborate the coordination properties of these dendritic ligands...
September 27, 2017: Journal of Inorganic Biochemistry
https://www.readbyqxmd.com/read/29031172/a-parapharyngeal-space-schwannoma-arising-from-the-vagus-nerve-a-case-report
#9
Conor Carroll, Manish Jagatiya, Dia Kamel, Jamal Siddiqi
INTRODUCTION: Tumours of the parapharyngeal space are rare. Only 0.5% of head and neck tumours occur in this space. Surgical excision of parapharyngeal space lesions is challenging because of the anatomical complexity of the area. PRESENTATION OF CASE: A 31-year-old male patient was referred by his general dental practitioner for removal of lower wisdom teeth due to multiple episodes of pericoronitis. At the initial examination, an incidental finding was made of a large fluctuant posterior oropharyngeal swelling...
October 5, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29031167/impaired-central-coherence-in-patients-with-anorexia-nervosa
#10
Sayo Hamatani, Masahito Tomotake, Tomoya Takeda, Naomi Kameoka, Masashi Kawabata, Hiroko Kubo, Masashi Ohta, Yukio Tada, Yukiko Tomioka, Shinya Watanabe, Masatoshi Inoshita, Makoto Kinoshita, Tetsuro Ohmori
The purpose of this study was to investigate the characteristics of central coherence in patients with anorexia nervosa (AN). 22 female patients with AN (median age = 31.50 (QD = 8.13) years) and 33 female healthy controls (HC) (median age = 28.00 (QD = 8.50) years) participated in the study. Their central coherence was assessed with the Rey Complex Figure Task (RCFT). Clinical symptoms were evaluated with the Beck Depression Inventory-II and the State-Trait Anxiety Inventory-Form JYZ. The results showed that AN patients' Central Coherence Index and accuracy scores in copy, 3-min delayed recall and 30-min delayed recall tasks of the RCFT were significantly lower than those of HC...
September 30, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29031163/ebola-virus-requires-phosphatidylinositol-3-5-bisphosphate-production-for-efficient-viral-entry
#11
Shirley Qiu, Anders Leung, Yuxia Bo, Robert A Kozak, Sai Priya Anand, Corina Warkentin, Fabiola D R Salambanga, Jennifer Cui, Gary Kobinger, Darwyn Kobasa, Marceline Côté
For entry, Ebola virus (EBOV) requires the interaction of its viral glycoprotein with the cellular protein Niemann-Pick C1 (NPC1) which resides in late endosomes and lysosomes. How EBOV is trafficked and delivered to NPC1 and whether this is positively regulated during entry remain unclear. Here, we show that the PIKfyve-ArPIKfyve-Sac3 cellular complex, which is involved in the metabolism of phosphatidylinositol (3,5) bisphosphate (PtdIns(3,5)P2), is critical for EBOV infection. Although the expression of all subunits of the complex was required for efficient entry, PIKfyve kinase activity was specifically critical for entry by all pathogenic filoviruses...
October 11, 2017: Virology
https://www.readbyqxmd.com/read/29031133/nmr-diffusometry-data-sampling-optimization-for-mixture-analysis
#12
Florence Franconi, Laurent Lemaire, Benjamin Siegler, Jean-Christophe Gimel, Patrick Saulnier
NMR diffusometry is a powerful but challenging method to analyze complex mixture. Each component diffuses differently, from the faster small species to the slower large species, corresponding to different signal attenuation. However, the method is highly sensitive to the quality of the acquired data and the performance of the processing used to resolve multiexponential signals influences. Adapting the signal decay sampling to the mixture composition is one way to improve the precision of the measure. In this work, we propose a prediction tool, based on the calculation of the Cramér-Rao lower bound to minimize the variance of diffusion coefficient estimation in order to determine the optimal number of diffusion gradient steps, the best diffusion gradient sampling (among linear, exponential, quadratic and sigmoidal ones) and the optimal maximum diffusion factor...
October 2, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29031127/patients-perceptions-and-experiences-of-living-with-a-surgical-wound-healing-by-secondary-intention-a-qualitative-study
#13
Dorothy McCaughan, Laura Sheard, Nicky Cullum, Jo Dumville, Ian Chetter
BACKGROUND: Most surgical wounds heal by primary intention, that is to say, the edges of the wound are brought together with sutures, staples, adhesive glue or clips. However, some wounds may be left open to heal (if there is a risk of infection, or if there has been significant tissue loss), and are known as 'surgical wounds healing by secondary intention'. They are estimated to comprise approximately 28% of all surgical wounds and are frequently complex to manage. However, they are under researched and little is known of their impact on patients' lives...
September 28, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29031124/a-relay-identification-fluorescence-probe-for-fe-3-and-phosphate-anion-and-its-applications
#14
Xu Tang, Yun Wang, Juan Han, Liang Ni, Lei Wang, Longhua Li, Huiqin Zhang, Cheng Li, Jing Li, Haoran Li
A simple relay identification fluorescence probe for Fe(3+) and phosphate anion with "on-off-on" switching was designed and synthesized based on the phenylthiazole and biphenylcarbonitrile. Probe 1 displayed highly selective and sensitive recognition to Fe(3+) in HEPES aqueous buffer (EtOH/H2O=2:8, v/v, pH=7.4) solutions. The optimized structures and HOMO and LUMO of probe 1 and [1-Fe(3+)] complex were obtained by the density functional theory (DFT) calculations with B3LYP as the exchange and correlation functional using a suite of Gaussian 09 programs...
October 9, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29031121/facilitating-decision-making-in-women-undergoing-genetic-testing-for-hereditary-breast-cancer-breconda-randomized-controlled-trial-results
#15
Kerry A Sherman, Christopher J Kilby, Laura-Kate Shaw, Caleb Winch, Judy Kirk, Kathy Tucker, Elisabeth Elder
BACKGROUND: Decision-making concerning risk-reducing mastectomy for women at hereditary risk of breast cancer entails complex personal choices. Deciding whether and how to restore breast shape after risk-reducing mastectomy is a key part of this process. We developed a web-based decision aid, BRECONDA (Breast Reconstruction Decision Aid), to assist women in decision-making regarding breast reconstruction. METHOD: This study assessed the efficacy of BRECONDA to assist women at increased risk of breast cancer in making decisions regarding risk-reducing mastectomy in terms of decisional conflict, knowledge, and satisfaction with information...
October 11, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/29031098/stepwise-construction-of-a-metabolic-network-in-event-b-the-heat-shock-response
#16
Usman Sanwal, Luigia Petre, Ion Petre
There is a high interest in constructing large, detailed computational models for biological processes. This is often done by putting together existing submodels and adding to them extra details/knowledge. The result of such approaches is usually a model that can only answer questions on a very specific level of detail, and thus, ultimately, is of limited use. We focus instead on an approach to systematically add details to a model, with formal verification of its consistency at each step. In this way, one obtains a set of reusable models, at different levels of abstraction, to be used for different purposes depending on the question to address...
September 30, 2017: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29031069/synthesis-and-biological-evaluation-of-a-platinum-ii-c-rgdyk-conjugate-for-integrin-targeted-photodynamic-therapy
#17
T Chatzisideri, S Thysiadis, S Katsamakas, P Dalezis, I Sigala, T Lazarides, E Nikolakaki, D Trafalis, O A Gederaas, M Lindgren, V Sarli
A cancer-targeting conjugate 4 of a cyclometalated [N,C,N-Pt(II)] complex bearing a NˆCˆN 1,3-di(2-pyridyl)-benzene with c(RGDyK) peptide as guiding molecule was designed and synthesized for real-time drug delivery monitoring in cancer cells and photodynamic therapy (PDT). This conjugate demonstrates a mild cytostatic effect to six cancer cell lines expressing integrins at different extent, while possessing promising features for PDT. Conjugate 4 demonstrated rapid cell uptake by receptor-mediated endocytosis and efficient generation of (1)O2 upon irradiation...
September 28, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29031046/contributors-to-young-drivers-driving-styles-a-comparison-between-israel-and-queensland
#18
Vera Skvirsky, Orit Taubman Ben-Ari, Timothy J Greenbury, Carlo G Prato
Among the numerous factors that contribute to young novice drivers' driving styles, personality characteristics, sociodemographic variables, family atmosphere, and friends' norms are known to have an important impact. However, cross-cultural comparisons are relatively rare in the safety literature concerning young drivers. This study aimed at comparing young drivers from Israel and Queensland (Australia) and examining the contribution of personality, sociodemographic, family and friends' aspects to their driving styles (reckless and careless; hostile and angry; anxious; patient and careful)...
October 10, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/29031031/riceanthernet-a-gene-co-expression-network-for-identifying-anther-and-pollen-development-genes
#19
Hong Lin, Jing Yu, Simon Pearce, Dabing Zhang, Zoe Wilson
In plants, normal anther and pollen development involves many important biological events and complex molecular regulatory coordination. Understanding gene regulatory relationships during male reproductive development is essential for fundamental biology and crop breeding. In this work, we developed a rice gene co-expression network for anther development (RiceAntherNet) that allows prediction of gene regulatory relationships during pollen development. RiceAntherNet was generated from 57 rice anther tissue microarrays across all developmental stages...
October 14, 2017: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29029371/structures-of-a-complex-hydrazinium-lead-iodide-n2h5-15pb3i21-possessing-pb2i9-5-pbi6-4-and-i-ions-and-%C3%AE-and-%C3%AE-n2h5-pbi3
#20
Joel S Miller, Eric Campbell, Brandon Dick, Arnold Rheingold, Chuang Zhang, Xiaojie Liu, Zeev Vardeny
Photovoltaic Perovskites, most notably methylammonium lead triiodide, (NH3Me)PbI3, have recently attracted considerable attention, and based upon the 'Goldschmidt Tolerance Factor' hydrazinium should be able to occupy the same cation site as methylammonium. The reaction of N2H5+I- with PbI2 in DMF results in three types of yellow crystals; hexagonal, needle-like, and rod-like, whose structures were determined at 100 K. The hexagonal [P63/m: a = 10.8906(10) Å; b = 37.845(5) Å] crystals possess isolated face sharing octahedral [Pb2I9]5-, [PbI6]4-, and I- ions...
October 13, 2017: Chemistry: a European Journal
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