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https://www.readbyqxmd.com/read/29220878/a-qualitative-study-of-the-experience-of-lower-extremity-wounds-and-amputations-among-people-with-diabetes-in-philadelphia
#1
Frances K Barg, Peter F Cronholm, Ebony E Easley, Trocon Davis, Michelle Hampton, D Scot Malay, Cornelius Donohue, Jinsup Song, Stephen R Thom, David J Margolis
The purpose of this study was to explore perceptions among people with type 2 diabetes about foot ulcers and lower extremity amputations. This was a qualitative observational study utilizing open-ended, semistructured interviews of 39 people with diabetes who were purposively selected because they had either a foot ulcer (n = 19) or a lower extremity amputation (n = 20). Interviews were audio-recorded, deidentified, and entered into NVivo 10.0 for coding and analysis. Our integrated analytic approach combined inductively and deductively derived codes that were applied to all transcripts...
December 8, 2017: Wound Repair and Regeneration
https://www.readbyqxmd.com/read/29220864/the-nature-of-catecholamine-containing-neurons-in-the-enteric-nervous-system-in-relationship-with-organogenesis-normal-human-anatomy-and-neurodegeneration
#2
G Natale, L Ryskalin, C L Busceti, F Biagioni, F Fornai
The gastrointestinal tract is provided with extrinsic and intrinsic innervation. The extrinsic innervation includes the classic vagal parasympathetic and sympathetic components, with afferent sensitive and efferent secretomotor fibers. The intrinsic innervations is represented by the enteric nervous system (ENS), which is recognized as a complex neural network controlling a variety of cell populations, including smooth muscle cells, mucosal secretory cells, endocrine cells, microvasculature, immune and inflammatory cells...
September 1, 2017: Archives Italiennes de Biologie
https://www.readbyqxmd.com/read/29220858/long-term-successful-closure-of-a-percutaneous-intragastric-trocar-tract-with-crossing-full-thickness-sutures-in-a-porcine-model
#3
Andrew C Storm, Hiroyuki Aihara, Matthew J Skinner, Marvin Ryou, Christopher C Thompson
Background and study aims A novel intragastric trocar placed using a percutaneous endoscopic gastrostomy technique enables the use of laparoscopic tools and procedures, including tissue stapling, cutting, suturing, and retraction. The aim of this porcine study was to determine long-term success of crossing full-thickness sutures in closure of the tract upon trocar withdrawal. Methods 10 trocars were placed in 5 animals. Each animal underwent a standardized tissue resection using a 5-mm stapler under gastroscopic guidance, and two full-thickness, absorbable, crossing sutures were used to close the trocar tracts...
December 8, 2017: Endoscopy
https://www.readbyqxmd.com/read/29220829/decreased-expression-of-the-polarity-regulatory-par-complex-predicts-poor-prognosis-of-the-patients-with-colorectal-adenocarcinoma
#4
Min-Kyung Yeo, Jin-Man Kim, Kwang-Sun Suh, Seok-Hyung Kim, Ok-Jun Lee, Kyung-Hee Kim
Partitioning defective (Par) proteins regulate cell polarity and differentiation. Par3, Par6β, and protein kinase Cζ (PKCζ), which are PAR complex members, have been shown to be associated with oncogenesis and progression. Herein, we report the expression pattern and clinical relevance of Par3, Par6β, and PKCζ in colorectal adenocarcinoma (CRAC). A total of 393 primary CRACs, 41 primary-metastatic CRAC pairs, 41 adenomas with low-grade dysplasia, and 41 nontumor colorectal tissue samples were examined by immunohistochemistry and Western blot assays for Par3, Par6β, and PKCζ protein expressions...
December 5, 2017: Translational Oncology
https://www.readbyqxmd.com/read/29220822/fatigue-and-biological-properties-of-ti-6al-4v-eli-cellular-structures-with-variously-arranged-cubic-cells-made-by-selective-laser-melting
#5
M Dallago, V Fontanari, E Torresani, M Leoni, C Pederzolli, C Potrich, M Benedetti
Traditional implants made of bulk titanium are much stiffer than human bone and this mismatch can induce stress shielding. Although more complex to produce and with less predictable properties compared to bulk implants, implants with a highly porous structure can be produced to match the bone stiffness and at the same time favor bone ingrowth and regeneration. This paper presents the results of the mechanical and dimensional characterization of different regular cubic open-cell cellular structures produced by Selective Laser Melting (SLM) of Ti6Al4V alloy, all with the same nominal elastic modulus of 3GPa that matches that of human trabecular bone...
December 5, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29220818/reuse-of-sustainable-materials-for-xylenol-orange-dye-and-copper-ii-ion-ammoniacal-removal
#6
M I Garrudo-Guirado, A Blanco-Flores, H P Toledo-Jaldin, V Sánchez-Mendieta, A R Vilchis-Néstor
Water pollution caused by heavy metals and organic compounds is an environmental problem with negative impact, making the restoration of water quality a priority. In this paper, the adsorption of xylenol orange dye (XO) on vitreous tuff mineral (VT) was studied. It was established that the adsorption capacity of VT was 45.17 mg/g. The removal was carried out by interactions between active sites on the surface of the material and the functional groups of the dye. The solid waste obtained from this process (VTXO) was reused as adsorbent material for Cu removal in the form of the complex Cu-NH3 because this process was done in an ammoniacal medium...
December 5, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/29220811/synergistic-effect-of-the-enzyme-complexes-comprising-agarase-carrageenase-and-neoagarobiose-hydrolase-on-degradation-of-the-red-algae
#7
Dae Hee Kang, Seung Kyou You, Young-Chul Joo, Sang Kyu Shin, Jeong Eun Hyeon, Sung Ok Han
In the practice of converting red algae biomass into biofuel or valuable biomaterials, the critical step is the decomposition process of the agarose to give fermentable monomeric sugars. In this study, we selected three enzymes such as agarase, carrageenase and neoagarobiose hydrolase to inducible the simultaneous hydrolysis of the major substrates such as agar and carrageenan constituting the pretreated red algae, and expressed the chimeric enzymes and formed a complexes through optimization of addition ratio...
December 2, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/29220797/primaquine-hybrids-as-promising-antimycobacterial-and-antimalarial-agents
#8
Kristina Pavić, Ivana Perković, Šárka Pospíšilová, Marta Machado, Diana Fontinha, Miguel Prudêncio, Josef Jampilek, Aidan Coffey, Lorraine Endersen, Hrvoje Rimac, Branka Zorc
Four series of primaquine (PQ) derivatives were screened for antitubercular and antiplasmodial activity: amides 1a-k, ureas 2a-s, semicarbazides 3a-c and bis-ureas 4a-u. Antimycobacterial activity of PQ derivatives against Mycobacterium tuberculosis (MTB), M. avium complex (MAC) and M. avium subsp. paratuberculosis (MAP) were evaluated in vitro and compared with PQ and the standard antitubercular drugs. In general, the PQ derivatives showed higher potency than the parent compound. Most of the compounds of series 1 and 2 showed high activity against MAP, comparable or even higher than the relevant drug ciprofloxacin, and weak or no activity against MTB and MAC...
December 2, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29220760/historical-trace-element-accumulation-in-marine-sediments-from-the-tamaulipas-shelf-gulf-of-mexico-an-assessment-of-natural-vs-anthropogenic-inputs
#9
Omar Celis-Hernandez, Leticia Rosales-Hoz, Andrew B Cundy, Arturo Carranza-Edwards, Ian W Croudace, Hector Hernandez-Hernandez
The Gulf of Mexico is considered one of the world's major marine ecosystems, supporting important fisheries and habitats such as barrier islands, mangrove forests, seagrass beds, coral reefs etc. It also hosts a range of complex offshore petroleum exploration, extraction, and refining industries, which may have chronic or acute impacts on ecosystem functioning. Previous work on the marine effects of this activity is geographically incomplete, and has tended to focus on direct hydrocarbon impacts, while impacts from other related contaminants (e...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220759/polymer-inclusion-membrane-to-access-zn-speciation-comparison-with-root-uptake
#10
Ruben Vera, Clàudia Fontàs, Josep Galceran, Olga Serra, Enriqueta Anticó
Metal speciation studies can be performed with a new technique based on a functionalized membrane. The estimation of not only the total amount of metal, but also the metal available to living organisms is very important. In this context, we have investigated the use of a polymer inclusion membrane (PIM) in a new tool for the determination of free metal ion concentration. In order to check the usefulness of PIM devices in metal speciation studies and metal availability to potato plants (Solanum tuberosum), Zn has been chosen as a case study...
December 5, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/29220738/increasing-value-and-reducing-waste-by-optimizing-the-development-of-complex-interventions-enriching-the-development-phase-of-the-medical-research-council-mrc-framework
#11
Nienke Bleijenberg, Janneke M de Man-van Ginkel, Jaap C A Trappenburg, Roelof G A Ettema, Carolien G Sino, Noor Heim, Thóra B Hafsteindóttir, David A Richards, Marieke J Schuurmans
BACKGROUND: In recent years there has been much emphasis on 'research waste' caused by poor question selection, insufficient attention to previous research results, and avoidable weakness in research design, conduct and analysis. Little attention has been paid to the effect of inadequate development of interventions before proceeding to a full clinical trial. OBJECTIVE: We therefore propose to enrich the development phase of the MRC Framework by adding crucial elements to improve the likelihood of success and enhance the fit with clinical practice METHODS: Based on existing intervention development guidance and synthesis, a comprehensive iterative intervention development approach is proposed...
December 5, 2017: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/29220725/sparse-view-neutron-photon-computed-tomography-object-reconstruction-and-material-discrimination
#12
Ali Pour Yazdanpanah, Jessica Hartman, Emma Regentova, Alexander Barzilov
Taking into account the advantages of both neutron- and photon-based systems, we propose combined neutron-photon computed tomography (CT) under a sparse-view setting and demonstrate its performance for 3D object visualization and material discrimination. We use a high-performance regularization method for CT reconstruction by combining regularization based on total variation (TV) and curvelet transform in cone beam geometry. It is coupled with proposed 2D material signatures which is pairs of photon to neutron transmission ratios and neutron transmission values per object space voxels...
November 28, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29220702/the-effect-of-subjective-awareness-measures-on-performance-in-artificial-grammar-learning-task
#13
Ivan I Ivanchei, Nadezhda V Moroshkina
Systematic research into implicit learning requires well-developed awareness-measurement techniques. Recently, trial-by-trial measures have been widely used. However, they can increase complexity of a study because they are an additional experimental variable. We tested the effects of these measures on performance in artificial grammar learning study. Four groups of participants were assigned to different awareness measures conditions: confidence ratings, post-decision wagering, decision strategy attribution or none...
December 5, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/29220699/hiv-1-tat-protein-induces-dna-damage-in-human-peripheral-blood-b-lymphocytes-via-mitochondrial-ros-production
#14
Rawan El-Amine, Diego Germini, Vlada V Zakharova, Tatyana Tsfasman, Eugene V Sheval, Ruy A N Louzada, Corinne Dupuy, Chrystèle Bilhou-Nabera, Aline Hamade, Fadia Najjar, Eric Oksenhendler, Marс Lipinski, Boris V Chernyak, Yegor S Vassetzky
Human immunodeficiency virus (HIV) infection is associated with B-cell malignancies in patients though HIV-1 is not able to infect B-cells. The rate of B-cell lymphomas in HIV-infected individuals remains high even under the combined antiretroviral therapy (cART) that reconstitutes the immune function. Thus, the contribution of HIV-1 to B-cell oncogenesis remains enigmatic. HIV-1 induces oxidative stress and DNA damage in infected cells via multiple mechanisms, including viral Tat protein. We have detected elevated levels of reactive oxygen species (ROS) and DNA damage in B-cells of HIV-infected individuals...
December 5, 2017: Redox Biology
https://www.readbyqxmd.com/read/29220698/synergistic-interaction-of-fatty-acids-and-oxysterols-impairs-mitochondrial-function-and-limits-liver-adaptation-during-nafld-progression
#15
Francesco Bellanti, Rosanna Villani, Rosanna Tamborra, Maria Blonda, Giuseppina Iannelli, Giorgia di Bello, Antonio Facciorusso, Giuseppe Poli, Luigi Iuliano, Carlo Avolio, Gianluigi Vendemiale, Gaetano Serviddio
The complete mechanism accounting for the progression from simple steatosis to steatohepatitis in nonalcoholic fatty liver disease (NAFLD) has not been elucidated. Lipotoxicity refers to cellular injury caused by hepatic free fatty acids (FFAs) and cholesterol accumulation. Excess cholesterol autoxidizes to oxysterols during oxidative stress conditions. We hypothesize that interaction of FAs and cholesterol derivatives may primarily impair mitochondrial function and affect biogenesis adaptation during NAFLD progression...
December 5, 2017: Redox Biology
https://www.readbyqxmd.com/read/29220677/a-powerful-approach-to-estimating-annotation-stratified-genetic-covariance-via-gwas-summary-statistics
#16
Qiongshi Lu, Boyang Li, Derek Ou, Margret Erlendsdottir, Ryan L Powles, Tony Jiang, Yiming Hu, David Chang, Chentian Jin, Wei Dai, Qidu He, Zefeng Liu, Shubhabrata Mukherjee, Paul K Crane, Hongyu Zhao
Despite the success of large-scale genome-wide association studies (GWASs) on complex traits, our understanding of their genetic architecture is far from complete. Jointly modeling multiple traits' genetic profiles has provided insights into the shared genetic basis of many complex traits. However, large-scale inference sets a high bar for both statistical power and biological interpretability. Here we introduce a principled framework to estimate annotation-stratified genetic covariance between traits using GWAS summary statistics...
December 7, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/29220670/qm-mm-modeling-of-the-hydrolysis-and-transfructosylation-reactions-of-fructosyltransferase-from-aspergillus-japonicas-an-enzyme-that-produces-prebiotic-fructooligosaccharide
#17
Jitrayut Jitonnom, James R Ketudat-Cairns, Supa Hannongbua
Fructosyltransferases (FTs) act on sucrose by cleaving the β-(2→1) linkage, releasing glucose, and then transferring the fructosyl group to an acceptor molecule. These enzymes are capable of producing prebiotic fructooligosaccharides (FOSs) that are of industrial interest. While several FOS-synthesizing enzymes FTs have been investigated, their catalytic mechanism is not yet fully understood, especially the molecular details of how FOS are enzymatically synthesized from sucrose. Here, we present a comparative quantum mechanics/molecular mechanics (QM/MM) study on the hydrolysis and transfructosylation reactions catalyzed by A...
November 24, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/29220666/chromatin-accessibility-dynamics-during-ipsc-reprogramming
#18
Dongwei Li, Jing Liu, Xuejie Yang, Chunhua Zhou, Jing Guo, Chuman Wu, Yue Qin, Lin Guo, Jiangping He, Shenyong Yu, He Liu, Xiaoshan Wang, Fang Wu, Junqi Kuang, Andrew P Hutchins, Jiekai Chen, Duanqing Pei
Cell-fate decisions remain poorly understood at the chromatin level. Here, we map chromatin remodeling dynamics during induction of pluripotent stem cells. ATAC-seq profiling of MEFs expressing Oct4-Sox2-Klf4 (OSK) reveals dynamic changes in chromatin states shifting from open to closed (OC) and closed to open (CO), with an initial burst of OC and an ending surge of CO. The OC loci are largely composed of genes associated with a somatic fate, while the CO loci are associated with pluripotency. Factors/conditions known to impede reprogramming prevent OSK-driven OC and skew OC-CO dynamics...
December 7, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29220665/mtorc1-activation-during-repeated-regeneration-impairs-somatic-stem-cell-maintenance
#19
Samantha Haller, Subir Kapuria, Rebeccah R Riley, Monique N O'Leary, Katherine H Schreiber, Julie K Andersen, Simon Melov, Jianwen Que, Thomas A Rando, Jason Rock, Brian K Kennedy, Joseph T Rodgers, Heinrich Jasper
The balance between self-renewal and differentiation ensures long-term maintenance of stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during periods of high regenerative pressure and is often compromised in aged animals. Here, we show that target of rapamycin (TOR) signaling is a key regulator of SC loss during repeated regenerative episodes. In response to regenerative stimuli, SCs in the intestinal epithelium of the fly and in the tracheal epithelium of mice exhibit transient activation of TOR signaling...
December 7, 2017: Cell Stem Cell
https://www.readbyqxmd.com/read/29220657/hnrnpk-recruits-pcgf3-5-prc1-to-the-xist-rna-b-repeat-to-establish-polycomb-mediated-chromosomal-silencing
#20
Greta Pintacuda, Guifeng Wei, Chloë Roustan, Burcu Anil Kirmizitas, Nicolae Solcan, Andrea Cerase, Alfredo Castello, Shabaz Mohammed, Benoît Moindrot, Tatyana B Nesterova, Neil Brockdorff
The Polycomb-repressive complexes PRC1 and PRC2 play a key role in chromosome silencing induced by the non-coding RNA Xist. Polycomb recruitment is initiated by the PCGF3/5-PRC1 complex, which catalyzes chromosome-wide H2A lysine 119 ubiquitylation, signaling recruitment of other PRC1 complexes, and PRC2. However, the molecular mechanism for PCGF3/5-PRC1 recruitment by Xist RNA is not understood. Here we define the Xist RNA Polycomb Interaction Domain (XR-PID), a 600 nt sequence encompassing the Xist B-repeat element...
December 7, 2017: Molecular Cell
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