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https://www.readbyqxmd.com/read/27753830/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#1
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27650288/reporting-and-dealing-with-missing-quality-of-life-data-in-rcts-has-the-picture-changed-in-the-last-decade
#2
REVIEW
S Fielding, A Ogbuagu, S Sivasubramaniam, G MacLennan, C R Ramsay
PURPOSE: Missing data are a major problem in the analysis of data from randomised trials affecting power and potentially producing biased treatment effects. Specifically focussing on quality of life outcomes, we aimed to report the amount of missing data, whether imputation was used and what methods and was the missing mechanism discussed from four leading medical journals and compare the picture to our previous review nearly a decade ago. METHODS: A random selection (50 %) of all RCTS published during 2013-2014 in BMJ, JAMA, Lancet and NEJM was obtained...
December 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27642883/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#3
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27637413/reporting-on-data-monitoring-committees-in-neonatal-randomised-controlled-trials-is-inconsistent
#4
L M Perrem, S Gosling, I Ravikumar, A S Khashan, J Miletin, C A Ryan, E Dempsey
AIM: To evaluate the reported use of Data Monitoring Committees (DMCs), the frequency of interim analysis, pre-specified stopping rules and early trial termination in neonatal randomised controlled trials (RCTs). METHODS: We reviewed neonatal RCTs published in four high impact general medical journals, specifically looking at safety issues including documented involvement of a DMC, stated interim analysis, stopping rules and early trial termination. We searched all journal issues over an 11-year period (2003-2013) and recorded predefined parameters on each item for RCTs meeting inclusion criteria...
September 16, 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/27470506/reporting-quality-of-randomised-controlled-trial-abstracts-among-high-impact-general-medical-journals-a-review-and-analysis
#5
Meredith Hays, Mary Andrews, Ramey Wilson, David Callender, Patrick G O'Malley, Kevin Douglas
OBJECTIVE: The aim of this study was to assess adherence to the Consolidated Standards of Reporting Trials (CONSORT) for Abstracts by five high-impact general medical journals and to assess whether the quality of reporting was homogeneous across these journals. DESIGN: This is a descriptive, cross-sectional study. SETTING: Randomised controlled trial (RCT) abstracts in five high-impact general medical journals. PARTICIPANTS: We used up to 100 RCT abstracts published between 2011 and 2014 from each of the following journals: The New England Journal of Medicine (NEJM), the Annals of Internal Medicine (Annals IM), The Lancet, the British Medical Journal (The BMJ) and the Journal of the American Medical Association (JAMA)...
July 28, 2016: BMJ Open
https://www.readbyqxmd.com/read/26650174/ischemic-optic-neuropathies
#6
(no author information available yet)
No abstract text is available yet for this article.
December 10, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/26378905/arthroscopic-partial-meniscectomy-for-meniscal-tears-a-review-and-commentary-on-a-study-by-nejm
#7
Anthony J Scillia, James D McDermott, Kimona Issa, Peter Goljan, Steven F Harwin, Anthony Festa, Vincent K McInerney
Arthroscopic partial meniscectomy (APM) has been demonstrated to be effective when performed in the appropriately indicated patient. However, a recent study published in the New England Journal of Medicine (NEJM) questioned whether or not the procedure actually had any clinical benefit whatsoever. Despite being a prospective, Level 1, randomized study, there are several aspects of the study that must be taken into consideration when interpreting the findings, including but not limited to the patient selection criteria, limited sample size, and lack of information regarding meniscal tear patterns...
July 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/26378444/results-of-vertebral-augmentation-treatment-for-patients-of-painful-osteoporotic-vertebral-compression-fractures-a-meta-analysis-of-eight-randomized-controlled-trials
#8
Lianhua Li, Jixin Ren, Jia Liu, Hao Wang, Xiaowei Wang, Zhi Liu, Tiansheng Sun
BACKGROUND: In 2009 two RCTs were publicated to question the efficacy of vertebroplasty comparing with sham treatment (ST) in the New England Journal of Medicine (NEJM), which provoked an academic debate on the efficacy of PVA. The purposes of our study were to compare clinical differences in pain relief, spinal functional outcomes, and overall quality of life between PVA and CT for painful osteoporotic VCFs. METHODS: We searched PubMed, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials and Web of Knowledge from January 1980 to June 2013 with Medical Subject Headings terms and keywords...
2015: PloS One
https://www.readbyqxmd.com/read/26100188/screening-mammography-update-and-review-of-publications-since-our-report-in-the-new-england-journal-of-medicine-on-the-magnitude-of-the-problem-in-the-united-states
#9
REVIEW
Archie Bleyer
RATIONALE AND OBJECTIVES: After a half century of clinical trials, expansive observations, vigorous advocacy and debate, screening mammography could not be in a more controversial condition, especially the potential harm of overdiagnosis. Despite a simple rationale (catch the cancer early and either prevent death or at least decrease the amount of therapy needed for cure), the estimates to date of overdiagnosis rates are conflicting and the interpretations complex. MATERIALS AND METHODS: Since the author's 2012 publication in the New England Journal of Medicine (NEJM), the peer-reviewed publications on overdiagnosis caused by screening mammography are reviewed and the NEJM analyses updated with three additional calendar years of results...
August 2015: Academic Radiology
https://www.readbyqxmd.com/read/24779345/immunocompetent-murine-models-for-the-study-of-glioblastoma-immunotherapy
#10
REVIEW
Taemin Oh, Shayan Fakurnejad, Eli T Sayegh, Aaron J Clark, Michael E Ivan, Matthew Z Sun, Michael Safaee, Orin Bloch, Charles D James, Andrew T Parsa
Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in clinical outcomes are modest, in no small part due to tumor-induced immunosuppressive mechanisms that promote immune escape and immuno-resistance. Immunotherapeutic strategies aimed at bolstering the immune response while neutralizing immunosuppression will play a critical role in improving treatment outcomes for glioblastoma patients...
2014: Journal of Translational Medicine
https://www.readbyqxmd.com/read/24256399/severe-sepsis-and-septic-shock
#11
(no author information available yet)
Severe Sepsis and Septic Shock Review Article, N Engl J Med 2013;369:840-851. In Table 2 (page 846), the grade given for "Continue fluid-challenge technique as long as there is hemodynamic improvement" (row 6 under Resuscitation) should have been UG, rather than 1C. The article is correct at NEJM.org.
November 21, 2013: New England Journal of Medicine
https://www.readbyqxmd.com/read/23515174/the-influence-of-endoscopic-vein-harvesting-on-outcomes-after-coronary-bypass-grafting-a-meta-analysis-of-267-525-patients
#12
REVIEW
Priya Sastry, Rasmus Rivinius, Rebecca Harvey, Richard A Parker, Ann-Kathrin Rahm, Dierk Thomas, Sukumaran Nair, Stephen R Large
In recent times, practice in cardiac surgery has shifted towards using endoscopic techniques to harvest the saphenous vein from the leg for use as a bypass graft. A paper published in the New England Journal of Medicine (NEJM) in 2009 raised concerns over increased graft occlusion rates in veins harvested endoscopically. This NEJM paper has been criticized, but has nonetheless been influential in guiding practice. We have undertaken this meta-analysis to provide evidence on the clinical outcomes of endoscopic vein harvesting (EVH), so that clinicians can make an informed judgement about whether this technique, popular as it is with patients, should still be offered...
December 2013: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/23233598/point-counterpoint-early-stage-hodgkin-lymphoma-and-the-role-of-radiation-therapy
#13
REVIEW
Ralph M Meyer, Richard T Hoppe
The results of recent clinical trials for the management of limited-stage Hodgkin lymphoma have led to considerable debate, especially regarding the role of radiation therapy. This review highlights those recent trials and provides perspectives regarding their interpretation from a radiation oncologist and a hematologist. The trial protocol is available at http://www.nejm.org/doi/suppl/10.1056/NEJMoa1111961/suppl_file/nejmoa1111961_protocol.pdf.
2012: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/23089378/-brown-white-beige-the-color-of-fat-and-new-therapeutic-perspectives-for-obesity
#14
REVIEW
E Kuhn, N Binart, M Lombès
Three articles published in the NEJM in 2009 have renewed the interest for brown adipose tissue (BAT) in humans. This review reports interesting new findings on adipocyte cell types that have been presented at the last meeting of the Endocrine Society in Houston, TX, in June 2012. Many studies have focused on identifying factors involved in brown adipocyte lineage, the site of adaptive thermogenesis. Indeed, the role of the transcription factors, such as PRDM16, in brown adipocyte differentiation has been unambiguously established...
October 2012: Annales D'endocrinologie
https://www.readbyqxmd.com/read/22821764/point-counterpoint-early-stage-hodgkin-lymphoma-and-the-role-of-radiation-therapy
#15
REVIEW
Ralph M Meyer, Richard T Hoppe
The results of recent clinical trials for the management of limited-stage Hodgkin lymphoma have led to considerable debate, especially regarding the role of radiation therapy. This review highlights those recent trials and provides perspectives regarding their interpretation from a radiation oncologist and a hematologist. The trial protocol is available at http://www.nejm.org/doi/suppl/10.1056/NEJMoa1111961/suppl_file/nejmoa1111961_protocol.pdf.
November 29, 2012: Blood
https://www.readbyqxmd.com/read/22676267/assessment-of-adherence-to-the-consort-statement-for-quality-of-reports-on-randomized-controlled-trial-abstracts-from-four-high-impact-general-medical-journals
#16
Saurav Ghimire, Eunjung Kyung, Wonku Kang, Eunyoung Kim
BACKGROUND: The extended Consolidated Standards of Reporting Trials (CONSORT) Statement for Abstracts was developed to improve the quality of reports of randomized controlled trials (RCTs) because readers often base their assessment of a trial solely on the abstract. To date, few data exist regarding whether it has achieved this goal. We evaluated the extent of adherence to the CONSORT for Abstract statement for quality of reports on RCT abstracts by four high-impact general medical journals...
2012: Trials
https://www.readbyqxmd.com/read/22633517/clinical-characteristics-and-response-to-prophylactic-fluconazole-of-preterm-vlbw-neonates-with-baseline-and-acquired-fungal-colonisation-in-nicu-data-from-a-multicentre-rct
#17
RANDOMIZED CONTROLLED TRIAL
P Manzoni, M Mostert, M A Latino, L Pugni, I Stolfi, L Decembrino, F Vagnarelli, G Corona, E Tridapalli, G Vetrano, L Memo, C Priolo, P Galletto, C Giovannozzi, E Gallo, R Pedicino, I Barberi, G Faldella, F Mosca, O S Saia, L Bollani, R Maragliano, G Ruffinazzi, C Tzialla, M Stronati, S Rizzollo, D Farina, D K Benjamin, P B Smith, E Jacqz-Aigrain, F Kaguelidou, M Cohen-Wolkowiez
BACKGROUND: Fungal colonisation by Candida spp. affects a high proportion of VLBW neonates in NICU. However, few data are available on the clinical characteristics of colonisation in preterm infants who are colonised at baseline via vertical transmission, compared to preterms who become colonised during their stay in NICU via horizontal transmission. MATERIAL AND METHODS: We reviewed the database of a multicentre, randomised trial of prophylactic fluconazole in VLBW neonates conducted in 8 Italian NICUs in the years 2004 and 2005 (Manzoni et al...
May 2012: Early Human Development
https://www.readbyqxmd.com/read/22556312/accessibility-and-transparency-of-editor-conflicts-of-interest-policy-instruments-in-medical-journals
#18
Elise Smith, Marie-Josée Potvin, Bryn Williams-Jones
BACKGROUND: There has been significant discussion about the need to manage conflict of interest (COI) in medical journals. This has lead many journals to implement policies to manage COI for authors and reviewers; however, surprisingly little attention has been focused on the COI of journal editors. OBJECTIVE: The goal of this exploratory study was to determine whether the policies were accessible to the public and to researchers, and to discuss the potential impact on public transparency...
November 2012: Journal of Medical Ethics
https://www.readbyqxmd.com/read/22372544/therapy-innovation-for-the-treatment-of-pancreatic-neuroendocrine-tumors
#19
REVIEW
Ferdinando Riccardi, Mimma Rizzo, Lucia Festino, Francesca Ambrosio, Carlo Molino, Generoso Uomo, Giacomo Cartenì
INTRODUCTION: Traditional therapeutic approaches for patients with advanced neuroendocrine tumors (NETs) have included treatment with somatostatin analogs, hepatic-directed therapies, interferon and cytotoxic chemotherapy. Current knowledge about biological behavior of pancreatic neuroendocrine tumors (pNETs) has increased in the last decade, and some studies have been conducted to translate in the clinical setting. Among several molecular agents investigated in patients with progressive pNETs, everolimus and sunitinib have been studied in large Phase III trials...
April 2012: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/22039194/magnitude-of-effects-in-clinical-trials-published-in-high-impact-general-medical-journals
#20
Konstantinos C M Siontis, Evangelos Evangelou, John P A Ioannidis
BACKGROUND: Prestigious journals select for publication studies that are considered most important and informative. We aimed to examine whether high-impact general (HIG) medical journals systematically demonstrate more favourable results for experimental interventions compared with the rest of the literature. METHODS: We scrutinized systematic reviews of the Cochrane Database (Issue 4, 2009) and meta-analyses published in four general journals (2008-09). Eligible articles included ≥1 binary outcome meta-analysis(es) pertaining to effectiveness with ≥1 clinical trial(s) published in NEJM, JAMA or Lancet...
October 2011: International Journal of Epidemiology
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