keyword
MENU ▼
Read by QxMD icon Read
search

skin pigmentation

keyword
https://www.readbyqxmd.com/read/28749546/familial-progressive-hyperpigmentation-a-family-resurvey-and-ultrastructural-skin-investigation
#1
Tingmei Wang, Hongwen Li, Yingying Dong, Man Hu, Qiuyun She, Yunhua Deng
Familial progressive hyperpigmentation (FPH) is an autosomal dominant genodermatosis characterized by hyperpigmented patches that increase in size and number with age. Since its initial description in an African-American family in 1971, only a few cases of FPH have been documented. A three-generation family with FPH in central China has also been reported. Here, we resurveyed that Chinese FPH family for a few unusual features including delayed age of onset and non-involvement of ocular and oral mucosae. Electron microscopic examination of skin from the proband of the family showed that there were more melanosomes in lesional keratinocytes than in perilesional keratinocytes...
July 27, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28748760/visible-light-therapy-molecular-mechanisms-and-therapeutic-opportunities
#2
Zandra C Félix Garza, Matthias Born, Peter A J Hilbers, Natal A W van Riel, Joerg Liebmann
Visible light is absorbed by photoacceptors in pigmented and non-pigmented mammalian cells, activating signaling cascades and downstream mechanisms that lead to the modulation of cellular processes. Most studies have investigated the molecular mechanisms and therapeutic applications of UV and the red to near infrared regions of the visible spectrum. However, considerably less effort has been dedicated to the UV-free blue part of the spectrum. In this review we discuss the current advances in the understanding of the molecular photoacceptors, downstream signaling mechanisms and the corresponding therapeutic opportunities in the context of inflammatory skin conditions of blue light photoreception in mammalian cells...
July 27, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28746718/association-of-incident-amelanotic-melanoma-with-phenotypic-characteristics-mc1r-status-and-prior-amelanotic-melanoma
#3
Steven Vernali, Weston T Waxweiler, Patrick M Dillon, Peter A Kanetsky, Irene Orlow, Li Luo, Klaus J Busam, Anne Kricker, Bruce K Armstrong, Hoda Anton-Culver, Stephen B Gruber, Richard P Gallagher, Roberto Zanetti, Stefano Rosso, Lidia Sacchetto, Terence Dwyer, Anne E Cust, David W Ollila, Colin B Begg, Marianne Berwick, Nancy E Thomas
Importance: We previously reported that survival is poorer from histopathologically amelanotic than pigmented melanoma because of more advanced stage at diagnosis. Identifying patients at risk of amelanotic melanoma might enable earlier diagnosis and improved survival; however, the phenotypic characteristics and underlying genetics associated with amelanotic melanoma are unknown. Objective: To determine whether phenotypic characteristics, carriage of MC1R variants, and history of amelanotic melanoma are associated with histopathologically amelanotic melanoma...
July 26, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28733999/retinyl-propionate-and-climbazole-combination-demonstrates-clinical-improvement-to-the-appearance-of-hyperpigmentation-and-deep-wrinkling-with-minimal-irritation
#4
Stacy Hawkins, Jean Adamus, Chung-Yi Chiang, Edwin Covell, Jaime O'Leary, Jian-Ming Lee
OBJECTIVE: To evaluate a combination of retinyl propionate and climbazole (RPC) compared to 0.1% retinol for its efficacy, tolerance and aging appearance. METHOD: Forty-five healthy Caucasian females, ages 40-70, with moderately photodamaged facial skin, were recruited for a 16 week randomized, double-blind, IRB approved facial study. The efficacy of RPC treatment was compared to 0.1% retinol, in the same product base formulation, with twice daily, split-face product application...
July 22, 2017: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/28729805/dental-treatment-considerations-for-a-pediatric-patient-with-incontinentia-pigmenti-bloch-sulzberger-syndrome
#5
Amy Yi-Ling Chen, Kevin Chen
Incontinentia pigmenti (IP) is a uncommon gene disorder, heritage with X-linked dominant mode. IP patients have a characteristic dentition varying from marked hypodontia to delayed eruption and conical crowns on both dentitions. A 5½-year-old girl, whose mother and younger sister were also diagnosed with IP, has the whirling-like pigmented skin lesion over her trunk and four extremities. Four primary teeth and multiple permanent tooth germs were found to be congenital missing. Dental considerations of further treatment were discussed with her parents including the preservation of primary molars, possible interim prosthesis in mixed or permanent dentition, full mouth rehabilitation with orthodontic and prosthodontic combined treatment, and implant therapy in adulthood...
April 2017: European Journal of Dentistry
https://www.readbyqxmd.com/read/28729131/eosinophilic-hyperplastic-lymphogranuloma-clinical-diagnosis-and-treatment-experience-of-41-cases
#6
Yang Jiang, Qingquan Hua, Jie Ren, Feng Zeng, Jianfei Sheng, Hua Liao, Zhijian Zhang, Hongxia Guan
PURPOSE: The purpose of this study was to investigate the clinical features of eosinophilic hyperplastic lymphogranuloma (EHLG) in the head and neck. MATERIALS AND METHODS: Collecting the patients who diagnose with EHLG by pathological examination. The EHLG patients with the masses involved regions, such as involved inguinal region, chest wall, abdominal wall, anterior superior iliac spine or clavicle, instead of head and neck were excluding. All of the participants will sign the informed consent form...
July 12, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28728169/correlations-between-macular-skin-and-serum-carotenoids
#7
Christopher D Conrady, James P Bell, Brian M Besch, Aruna Gorusupudi, Kelliann Farnsworth, Igor Ermakov, Mohsen Sharifzadeh, Maia Ermakova, Werner Gellermann, Paul S Bernstein
Purpose: Ocular and systemic measurement and imaging of the macular carotenoids lutein and zeaxanthin have been employed extensively as potential biomarkers of AMD risk. In this study, we systematically compare dual wavelength retinal autofluorescence imaging (AFI) of macular pigment with skin resonance Raman spectroscopy (RRS) and serum carotenoid levels in a clinic-based population. Methods: Eighty-eight patients were recruited from retina and general ophthalmology practices from a tertiary referral center and excluded only if they did not have all three modalities tested, had a diagnosis of macular telangiectasia (MacTel) or Stargardt disease, or had poor AFI image quality...
July 1, 2017: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/28727930/visual-perception-of-british-women-s-skin-color-distribution-in-two-nonindustrialized-societies-the-maasai-and-the-tsimane
#8
Bernhard Fink, Marina Butovskaya, Piotr Sorokowski, Agnieszka Sorokowska, Paul J Matts
In women with lightly pigmented skin in particular, facial skin color homogeneity decreases with age, primarily due to chronic exposure to solar ultraviolet radiation (UVR), leading to a decrease in perceived health and attractiveness. Perception of female skin may be influenced by continuous exposure to, and thus familiarity with, age-related changes in visible skin condition in a given society. Men and women of two traditional societies, the Maasai (Tanzania) and the Tsimane' (Bolivia), unfamiliar with lighter colored skin, judged images of British women's facial skin for age, health, and attractiveness...
July 2017: Evolutionary Psychology: An International Journal of Evolutionary Approaches to Psychology and Behavior
https://www.readbyqxmd.com/read/28726212/melasma-an-up-to-date-comprehensive-review
#9
REVIEW
Oluwatobi A Ogbechie-Godec, Nada Elbuluk
Melasma is a common acquired condition of symmetric hyperpigmentation, typically occurring on the face, with higher prevalence in females and darker skin types. Multiple etiologies, including light exposure, hormonal influences, and family history, have been implicated in the pathogenesis of this disorder. Overall prevalence ranges widely at 1-50%, since values are typically calculated within a specific ethnic population within a geographic region. Histologically, melasma can display increased epidermal and/or dermal pigmentation, enlarged melanocytes, increased melanosomes, solar elastosis, dermal blood vessels, and, occasionally, perivascular lymphohistiocytic infiltrates...
July 19, 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/28725249/two-years-results-of-electronic-brachytherapy-for-basal-cell-carcinoma
#10
Rosa Ballester-Sánchez, Olga Pons-Llanas, Cristian Candela-Juan, Blanca de Unamuno-Bustos, Francisco Javier Celada-Alvarez, Alejandro Tormo-Mico, Jose Perez-Calatayud, Rafael Botella-Estrada
PURPOSE: The use of radiation therapy (RT) for non-melanoma skin cancer (NMSC) has been changing throughout the last century. Over the last decades, the use of radiotherapy has surged with the development of new techniques, applicators, and devices. In recent years, electronic brachytherapy (eBT) devices that use small x-ray sources have been introduced as alternative to radionuclide dependence. Nowadays, several devices have been incorporated, with a few series reported, and with a short follow-up, due to the recent introduction of these systems...
June 2017: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/28723852/effects-of-a-skin-barrier-cream-on-management-of-incontinence-associated-dermatitis-in-older-women-a-cluster-randomized-controlled-trial
#11
Yuka Kon, Yoshie Ichikawa-Shigeta, Terumi Iuchi, Yukari Nakajima, Gojiro Nakagami, Keiko Tabata, Hiromi Sanada, Junko Sugama
PURPOSE: The purpose of this study was to examine the effects of a skin barrier cream with moisturization and skin-protectant characteristics for improving the severity of incontinence-associated dermatitis (IAD) pertaining to the skin physiology and appearance. We measured the following outcomes: (1) skin physiological characteristics indicating skin protection and enhancement of the skin's moisture barrier (stratum corneum hydration, dermis hydration level, transepidermal water loss, and skin pH); and (2) changes in skin appearance (the degree of erythema and pigmentation, and the sulcus cutis condition)...
July 18, 2017: Journal of Wound, Ostomy, and Continence Nursing
https://www.readbyqxmd.com/read/28722334/potential-emerging-treatment-in-vitiligo-using-er-yag-in-combination-with-5fu-and-clobetasol
#12
Fatemeh Mokhtari, Anis Bostakian, Zabihollah Shahmoradi, Tohid Jafari-Koshki, Fariba Iraji, Gita Faghihi, Sayed Mohsen Hosseini, Behzad Bafandeh
BACKGROUND: Vitiligo is a pigmentary disorder of skin affecting at least 1% of the world population of all races in both sexes. Its importance is mainly due to subsequent social and psychological problems rather than clinical complications. Various treatment choices are available for vitiligo; however, laser-based courses have shown to give more acceptable results. OBJECTIVE: The aim of this trial was to evaluate the efficacy of Er:YAG laser as a supplementary medicine to topical 5FU and clobetasol in vitiligo patients...
July 19, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/28721529/-dermoscopy-for-malignant-and-benign-skin-tumors-indication-and-standardized-terminology
#13
A Blum, J Kreusch, W Stolz, H Haenssle, R Braun, R Hofmann-Wellenhof, P Tschandl, I Zalaudek, H Kittler
Dermoscopy has a high diagnostic accuracy in pigmented and nonpigmented malignant and benign skin tumors. These microscopic in vivo examinations with polarized and nonpolarized light are effective in the early detection of malignant skin tumors and reduce the number of unnecessary excisions of benign skin tumors. The selection of the skin lesions is crucial for the diagnostic accuracy of the dermoscopic examination. Not only large pigmented skin lesions, but also small hypo-, de-, or nonpigmented skin lesions, should be examined dermatoscopically as well as skin lesions that have changed in shape and/or color...
July 18, 2017: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
https://www.readbyqxmd.com/read/28713102/-contemporary-use-of-radiosynoviorthesis-in-chronic-polyarthrtitis
#14
Robert Zwolak, Maria Majdan
Radiosynoviorthesis is used for local treatment of recurrent joint effusions, leads to necrosis of inflamed synovium due to beta radiation energy served after intraarticular radionuclide administration. The aim of the therapy is destruction and fibrosis of abnormal, hypertrophic synovial membrane and then full recovery of its normal function after local corticosteroids and systemic modifying drugs failure. Radiosynoviorthesis is effective in different type of peripheral arthritis like rheumatoid arthritis, inflammatory spondyloarthtropaties, gout, chondrocalcinosis, pigmented villo-nodular synovitis, recurrent knee effusion after total joint replacement, idiopathic knee joint effusion, osteoarthritis and secondary prevention of intraarticular bleeding in haemophilia...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28711237/precise-role-of-dermal-fibroblasts-on-melanocyte-pigmentation
#15
REVIEW
Yinjuan Wang, Céline Viennet, Sophie Robin, Jean-Yves Berthon, Li He, Philippe Humbert
Dermal fibroblasts are traditionally recognized as synthesizing, remodeling and depositing collagen and extracellular matrix, the structural framework for tissues, helping to bring thickness and firmness to the skin. However, the role of fibroblasts on skin pigmentation arouses concern recently. More is known about the interactions between epidermal melanocytes and keratinocytes. This review highlights the importance of fibroblast-derived melanogenic paracrine mediators in the regulation of melanocyte activities...
July 1, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28710811/insights-from-zebrafish-on-human-pigment-cell-disease-and-treatment
#16
REVIEW
Cynthia D Cooper
Black pigment cells, melanocytes, arise early during development from multipotent neural crest cells. Melanocytes protect human skin from DNA damaging sunrays and provide color for hair, eyes and skin. Several disorders and diseases originate from these cells, including the deadliest skin cell cancer, melanoma. Thus, melanocytes are critical for a healthy life and for protecting humans from disease. Due to the ease of visualizing pigment cells through transparent larvae skin and conserved roles for zebrafish melanophore genes to mammalian melanocyte genes, zebrafish larvae offer a biologically relevant model for understanding pigment cell development and disease in humans...
July 14, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28707485/common-and-uncommon-adverse-cutaneous-reactions-to-erlotinib-a-study-of-20-chinese-patients-with-cancer
#17
Huiling Zhu, Zhe Zhu, Weining Huang, Xiping Cheng, Jiaxi He, Chunping Xiong, Jiande Han
Erlotinib, an epidermal growth factor receptor tyrosine kinase inhibitor, is used for treating non-small cell lung cancers. It is frequently known to cause skin toxicities. Systemic toxicities and anaphylactic cutaneous reactions have been rarely mentioned. Adverse cutaneous reactions were reported in 20 patients, including 6 cases of anaphylactic dermatitis, 12 cases of acneiform rash, 9 cases of xerosis, 5 cases of nail changes, and 4 cases of hair changes. One case of anaphylactic dermatitis manifested as erythema with swelling on the face and neck, and others as erosive and scaly erythema on the fold of skin, or red macules, papules, plaques, and pigmentation on the whole body...
July 14, 2017: Cutaneous and Ocular Toxicology
https://www.readbyqxmd.com/read/28705516/dermoscopy-of-pigmented-actinic-keratosis-of-the-face-a-study-of-232-cases
#18
A Kelati, H Baybay, E Moscarella, G Argenziano, S Gallouj, F Z Mernissi
The diagnosis of pigmented actinic keratosis (PAK) is often challenging because of overlapping features with lentigo maligna. OBJECTIVE: To investigate dermoscopic patterns of PAK according to their different evolutionary stages, and to correlate the pattern with clinical characteristics of the patients. METHODS: Descriptive and analytical study of 232 PAK. Dermoscopic patterns were divided into two categories: the follicule surroundings' abnormalities (FSA) and follicular keratosis' abnormalities (FKA)...
July 11, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/28702965/hard-to-face-cutaneous-malignant-melanoma
#19
M Vaccaro, M Lentini, J Lotti, M Fioranelli, M G Roccia, T Lotti, C Guarneri
An 88-year-old Caucasian man recently sought medical attention due to recrudescence of skin disease in the area of previously excised nodule (in 2002) on the nose dorsum. The original lesion was clinically considered as a pigmented basal cell carcinoma, after which histological examination revealed a superficial spreading melanoma in vertical growth face (Clark level IV; Breslow thickness 2.1 mm) arising from a pre-existing nevus. The adjacent skin also showed significant actinic damage both in the epidermis and in the dermis...
July 13, 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28702067/quantifying-phenotype-environment-matching-in-the-protected-kerry-spotted-slug-mollusca-gastropoda-using-digital-photography-exposure-to-uv-radiation-determines-cryptic-colour-morphs
#20
Aidan O'Hanlon, Kristina Feeney, Peter Dockery, Michael J Gormally
BACKGROUND: Animal colours and patterns commonly play a role in reducing detection by predators, social signalling or increasing survival in response to some other environmental pressure. Different colour morphs can evolve within populations exposed to different levels of predation or environmental stress and in some cases can arise within the lifetime of an individual as the result of phenotypic plasticity. Skin pigmentation is variable for many terrestrial slugs (Mollusca: Gastropoda), both between and within species...
2017: Frontiers in Zoology
keyword
keyword
57744
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"