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https://www.readbyqxmd.com/read/28431132/revealing-the-biochemical-and-genetic-basis-of-colour-variation-in-a-polymorphic-lizard
#1
Claire A McLean, Adrian Lutz, Katrina J Rankin, Devi Stuart-Fox, Adnan Moussalli
Determining the mechanistic and genetic basis of animal coloration is essential to understand the costs and constraints on colour production, and the evolution and maintenance of phenotypic variation. However, genes underlying structural colour and widespread pigment classes apart from melanin remain largely uncharacterised, in part due to restricted taxonomic focus. We combined liquid chromatography-mass spectrometry and RNA-seq gene expression analyses to characterise the pigments and genes associated with skin colour in the polymorphic lizard, Ctenophorus decresii...
April 18, 2017: Molecular Biology and Evolution
https://www.readbyqxmd.com/read/28429999/beneficial-effects-of-oral-supplementation-with-ovoderm-on-human-skin-physiology-two-pilot-studies
#2
Andrés Aguirre, Erena Gil-Quintana, Marisa Fenaux, Sandra Erdozain, Itziar Sarria
Collagens and hyaluronic acid have long been used in pharmaceuticals and food supplements for the improvement of skin elasticity and hydration. These compounds provide the building blocks of the skin. Ovoderm is an oral supplement obtained from eggshells that contains naturally occurring collagen and glycosaminoglycans, such as hyaluronic acid. We evaluated the efficacy of Ovoderm on skin biophysical parameters related to cutaneous aging such as elasticity, hydration, and pigmentation. Two pilot studies were run to assess the effect of daily oral supplementation with 300 mg Ovoderm on skin parameters...
April 21, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28429191/melanogenesis-inhibition-in-mice-using-a-low-fluence-1064-nm-q-switched-neodymium-doped-yttrium-aluminum-garnet-laser-a-pilot-study
#3
Jae-Hui Nam, Joon Hong Min, Wang-Kyun Kim, Sunmin Yim, Won-Serk Kim
A low-fluence 1064-nm Q-switched neodymium-doped yttrium aluminum garnet laser, or laser toning, has yielded favorable outcomes in various benign pigmented disorders. However, the exact mechanism of action of laser toning has not been fully elucidated. We sought to determine the inhibitory effect of laser toning on melanogenesis and to assess how laser passes influence the outcomes. To produce perceptible pigmentation, nine HRM-2 melanin-possessing hairless mice were treated with ultraviolet (UV) B radiation on the dorsal skin...
April 20, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28417066/ezogabine-skin-discoloration-is-reversible-after-discontinuation
#4
Sally V Mathias, Bassel W Abou-Khalil
There is concern that bluish skin discoloration associated with ezogabine treatment could be permanent. We present a case of ezogabine-induced skin discoloration that resolved completely after discontinuation. A 55-year-old woman started ezogabine 400 mg three times a day at age 41. Bluish pigmentation over the toe nails, finger nails, around eyes and over and around lips was first noted after 5 years of treatment. Ezogabine was discontinued eight years after initiation. Skin discoloration improved within 6 months and completely resolved within 6 years of discontinuation...
2017: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/28412633/relationship-among-color-development-anthocyanin-and-pigment-related-gene-expression-in-crimson-seedless-grapes-treated-with-abscisic-acid-and-sucrose
#5
Daniela Olivares, Carolina Contreras, Victoria Muñoz, Sebastián Rivera, Mauricio González-Agüero, Julio Retamales, Bruno G Defilippi
'Crimson Seedless' is one of the most important table grape varieties in Chile, but under certain environmental conditions, the fruit exhibits inadequate red color development, causing economic losses due to lower product quality. The use of plant growth regulators, such as abscisic acid (ABA) and ethylene, during development increases the anthocyanin content of the skin, improving the color of the berry. Recently, sucrose has been identified as a signaling molecule capable of regulating the expression of genes of the anthocyanin biosynthesis pathway...
April 6, 2017: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/28403275/a-difference-in-cutaneous-pigmentary-response-to-led-versus-halogen-incandescent-visible-light-a-case-report-from-a-single-center-investigational-clinical-trial-determining-a-minimal-pigmentary-visible-light-dose
#6
Teo Soleymani, Nicholas A Soter, Lorcan M Folan, Nada Elbuluk, Uchenna R Okereke, David E Cohen
<p>BACKGROUND: While most of the attention regarding skin pigmentation has focused on the effects on ultraviolet radiation, the cutaneous effects of visible light (400 to 700nm) are rarely reported. In this report, we describe a case of painful erythema and induration that resulted from direct irradiation of UV-naïve skin with visible LED light in a patient with Fitzpatrick type II skin.</p> <p>METHODS AND RESULTS: A 24-year-old healthy woman with Fitzpatrick type II skin presented to our department to participate in a clinical study...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28403262/combination-of-in-office-chemical-peels-with-a-topical-comprehensive-pigmentation-control-product-in-skin-of-color-subjects-with-facial-hyperpigmentation
#7
Jeanine Downie, Katie Schneider, Lisa Goberdhan, Elizabeth T Makino, Rahul C Mehta
<p>Dyschromia is one of the primary complaints for patients with skin of color. Treatments need to achieve a balance between tolerability and efficacy to address existing hyperpigmentation without causing additional damage that could trigger post-inflammatory hyperpigmentation (PIH). An open-label, single-center study was conducted to assess the efficacy of a novel comprehensive pigmentation control serum (LYT2) combined with a series of three very superficial chemical peels (VP) in skin of color subjects...
April 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/28403059/mycobacterium-gordonae-skin-infection-in-an-immunocompetent-child
#8
Bridget Freyne, Nigel Curtis
Mycobacterium gordonae is a slow growing, pigmented, nontuberculous mycobacterium. It is commonly associated with environmental contamination of clinical specimens, but it is also a recognized pathogen in immunocompromised hosts. We describe an immunocompetent child with a spontaneously occurring skin ulcer on the face caused by M. gordonae infection.
May 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/28401345/vitamin-d-in-european-children-statement-from-the-european-academy-of-paediatrics-eap
#9
Zachi Grossman, Adamos Hadjipanayis, Tom Stiris, Stefano Del Torso, Jean-Christophe Mercier, Arunas Valiulis, Raanan Shamir
Vitamin D is synthesized in human skin upon sun exposure and is also a nutrient. It regulates calcium and phosphate metabolism and is essential for the maintenance of bone health. Vitamin D supplementation during infancy, in order to prevent rickets, is universally accepted. Many human cell types carry vitamin D receptor, this being a drive for conducting studies on the possible association between vitamin D status and other diseases. Studies have affirmed that a considerable number of healthy European children may be vitamin D deficient, especially in high-risk groups (darker pigmented skin, living in areas with reduced sun exposure and other disorders)...
April 12, 2017: European Journal of Pediatrics
https://www.readbyqxmd.com/read/28398611/regulation-of-mir-21-expression-in-human-melanoma-via-uv-ray-induced-melanin-pigmentation
#10
Kuan-Yu Lin, Chien-Min Chen, Cheng-You Lu, Chun-Yuan Cheng, Yu-Hsin Wu
Excessive environmental ultraviolet (UV) radiation produces genetic mutations that can lead to skin cancer. This study was designed to assess the potential inhibitory activity of microRNA-21 (miR-21) on the UV irradiation-stimulated melanogenesis signal pathway in melanoma cells. The molecular mechanism of miR-21-induced inhibitory activity on UV-ray-stimulated melanogenesis-regulating proteins was examined in A375.S2 human melanoma and B16F10 mouse melanoma cells. UV irradiation for 30 min induced melanogenesis signal pathway by increasing melanin production and the number of A375...
April 11, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28394665/comparison-of-q-switched-nd-yag-laser-alone-versus-its-combination-with-ultra-pulse-co2-laser-for-the-treatment-of-black-tattoo
#11
Mithila Vanarase, Ram Krishan Gautam, Pooja Arora, Sonali Bajaj, Neha Meena, Ananta Khurana
BACKGROUND: Q-switched lasers are conventionally used for the treatment of black tattoo. However they require multiple sittings and the response may be slow due to competing epidermal pigment in dark skin. OBJECTIVE: To compare the efficacy of Q Switched Nd:YAG laser alone with its combination with ultrapulse CO2 in black tattoo removal. MATERIALS AND METHODS: Sixty patients of black tattoo were randomized into two groups. Group A was treated with QS Nd:YAG laser (1064 nm) alone and group B received combination of ablative ultrapulse CO2 followed by fixed dose QS Nd:YAG laser (1064 nm), at 6 weeks interval for a maximum of 6 sittings...
April 10, 2017: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/28392346/uchl1-regulates-melanogenesis-through-controlling-mitf-stability-in-human-melanocytes
#12
Eun Young Seo, Seon-Pil Jin, Kyung-Cheol Sohn, Chi-Hyun Park, Dong Hun Lee, Jin Ho Chung
Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is involved in many signaling pathways via the ubiquitin-proteasome system. UCHL1 is expressed in the human skin and serves as a neuronal marker; however, its functions in melanogenesis remain unknown. Here, we investigated the role of UCHL1 in melanogenesis, and elucidated the underlying mechanism using human melanocytes. UCHL1 downregulation by siRNA resulted in upregulation of microphthalmia-associated transcription factor (MITF), tyrosinase, dopachrome tautomerase (DCT), tyrosinase-related protein 1 (TRP-1), and melanin...
April 6, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/28389037/idiopathic-atrophoderma-of-pasini-and-pierini-a-case-study-of-collagen-and-elastin-texture-by-multiphoton-microscopy
#13
Gislaine Vieira-Damiani, Denise Lage, Patrícia Érica Christofoletti Daldon, Caroline Romanelli Tibúrcio Alves, Maria Letícia Cintra, Konradin Metze, Javier Adur, Vitor B Pelegati, Hernandes F Carvalho, Carlos Lenz Cesar
BACKGROUND: The diagnosis of idiopathic atrophoderma of Pasini and Pierini (IAPP) relies on typical clinical features, particularly distinctive pigmented ovular/round depressed plaques. Histologic examination often reveals no obvious changes, but patterns of collagen distribution, using multiphoton imaging and second harmonic generation can help track hidden details of tissue organization contributing to atrophy. OBJECTIVE: To identify histologic features that distinguish IAPP from unaffected skin...
April 4, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28384882/polymyxin-b-induced-diffuse-cutaneous-hyperpigmentation
#14
Sandeep Lahiry, Shouvik Choudhury, Ayan Mukherjee, Prajesh Kiran Bhunya, Moumita Bala
Polymyxin B is a polypeptide-antibiotic, primarily used for resistant Gram-negative infections, first obtained from bacterium Bacillus polymyxa in the late 1940s. Antibiotic spectrum are restricted to mainly gram negative bacterias like Enterobacter, E. coli, Klebsiella, Salmonella, Pasteurella, Bordetella, Shigella; and particularly organisms like Pseudomonas aeruginosa and Acinetobacter baumannii, which are extremely potent to acquire antibiotic resistance. Side effects include neurotoxicity and acute renal tubular necrosis...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28382139/in-vivo-imaging-of-experimental-melanoma-tumors-using-the-novel-radiotracer-68-ga-nodaga-procainamide-pca
#15
István Kertész, András Vida, Gábor Nagy, Miklós Emri, Antal Farkas, Adrienn Kis, János Angyal, Noémi Dénes, Judit P Szabó, Tünde Kovács, Péter Bai, György Trencsényi
PURPOSE: The most aggressive form of skin cancer is the malignant melanoma. Because of its high metastatic potential the early detection of primary melanoma tumors and metastases using non-invasive PET imaging determines the outcome of the disease. Previous studies have already shown that benzamide derivatives, such as procainamide (PCA) specifically bind to melanin pigment. The aim of this study was to synthesize and investigate the melanin specificity of the novel (68)Ga-labeled NODAGA-PCA molecule in vitro and in vivo using PET techniques...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28381809/coumestrol-down-regulates-melanin-production-in-melan-a-murine-melanocytes-through-degradation-of-tyrosinase
#16
Jeong Ah Hwang, Nok Hyun Park, Yong Joo Na, Hae Kwang Lee, John Hwan Lee, Yong Jin Kim, Chang Seok Lee
Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is known to have anti-aging ability, but its potential depigmenting efficacy has not been evaluated...
2017: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28381588/inference-on-the-genetic-basis-of-eye-and-skin-colour-in-an-admixed-population-via-bayesian-linear-mixed-models
#17
Luke R Lloyd-Jones, Matthew R Robinson, Gerhard Moser, Jian Zeng, Sandra Beleza, Hua Tang, Gregory S Barsh, Peter M Visscher
Genetic association studies in admixed populations are under-represented in the genomics literature, with a key concern for researchers being the adequate control of spurious associations due to population structure. Linear mixed models (LMMs) are well suited for genome-wide association studies (GWAS) because they account for both population stratification and cryptic relatedness and achieve increased statistical power by jointly modelling all genotyped markers. Additionally, Bayesian LMMs allow for more flexible assumptions about the underlying distribution of genetic effects, and can concurrently estimate the proportion of phenotypic variance explained by genetic markers...
April 4, 2017: Genetics
https://www.readbyqxmd.com/read/28380269/the-opinion-of-dermoscopy-experts-about-teledermoscopy-involving-primary-care-physicians-and-dermatologists
#18
N A Kukutsch, G Argenziano, W Bergman
Many dermatologists use teledermoscopy to seek second advice from experts for difficult lesions. Teledermoscopy by primary care physicians (PCP) is still controversial but already has been implemented in several regions. Since there are only few studies published about teledermoscopy in the hand of PCP with poor level of evidence we asked the opinion of dermoscopy experts (board members of the International Dermoscopy Society (IDS)). (1-6) Furthermore, we investigated the routing of patients with a suspicious pigmented skin lesion and the use of teledermoscopy in different countries...
April 5, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/28376557/-infection-associated-acute-posterior-multifocal-placoid-pigment-epitheliopathy
#19
F Jordan, U Voigt, J Dawczynski, R Augsten, D Meller
Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare inflammatory chorioretinopathy, which mainly affects young light-skinned, myopic adults between 20 and 30 years of age. The exact aetiology of APMPPE is unknown. Some patients report a viral or flu-like illness preceding the onset of APMPPE symptoms. This condition is usually bilateral and self-limiting with a good overall prognosis. Visual loss is sudden, but usually temporary. Relapses are very rare. Foveal involvement may lead to a worse visual prognosis...
April 4, 2017: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/28372251/chlorogenic-acid-anthocyanin-and-flavan-3-ol-biosynthesis-in-flesh-and-skin-of-andean-potato-tubers-solanum-tuberosum-subsp-andigena
#20
Matías Ariel Valiñas, María Luciana Lanteri, Arjen Ten Have, Adriana Balbina Andreu
Natural variation of Andean potato was used to study the biosynthesis of phenolic compounds. Levels of phenolic compounds and corresponding structural gene transcripts were examined in flesh and skin of tubers. Phenolic acids, mainly chlorogenic acid (CGA), represent the major compounds, followed by anthocyanins and flavan-3-ols. High-anthocyanin varieties have high levels of CGA. Both metabolite and transcript levels were higher in skin than in flesh and showed a good correspondence. Two hydroxycinnamoyl-CoA transferases (HCT/HQT) have been involved in CGA production, of which HCT reflects CGA levels...
August 15, 2017: Food Chemistry
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