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Sympathetically maintained pain

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https://www.readbyqxmd.com/read/29452441/assessing-the-safety-and-efficacy-of-regional-anesthesia-for-lower-extremity-microvascular-reconstruction-enhancing-recovery
#1
Qing Zhao Ruan, Shawn Diamond, Scott Zimmer, Matthew L Iorio
BACKGROUND: Perioperative pain, increased sympathetic tone, and peripheral vasospasm may be safely managed with regional nerve blockade during microvascular reconstruction in the lower extremity. Limited reports exist in this setting; therefore, we evaluated our use of peripheral nerve catheters (PNCs) during microvascular limb salvage to determine safety and efficacy for both patient and flap. METHODS: A single-institution, retrospective review of a prospectively maintained database on all patients with lower extremity free tissue transfers between 2012 and 2017 was completed...
February 16, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29229444/neural-control-of-choroidal-blood-flow
#2
REVIEW
Anton Reiner, Malinda E C Fitzgerald, Nobel Del Mar, Chunyan Li
The choroid is richly innervated by parasympathetic, sympathetic and trigeminal sensory nerve fibers that regulate choroidal blood flow in birds and mammals, and presumably other vertebrate classes as well. The parasympathetic innervation has been shown to vasodilate and increase choroidal blood flow, the sympathetic input has been shown to vasoconstrict and decrease choroidal blood flow, and the sensory input has been shown to both convey pain and thermal information centrally and act locally to vasodilate and increase choroidal blood flow...
December 8, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/29189275/ultrasound-assisted-versus-fluoroscopic-guided-lumbar-sympathetic-ganglion-block-a-prospective-and-randomized-study
#3
Jung-Hee Ryu, Chang Soon Lee, Yong-Chul Kim, Sang Chul Lee, Hariharan Shankar, Jee Youn Moon
BACKGROUND: Fluoroscopy (FL)-guided lumbar sympathetic ganglion block (LSGB) is widely performed to diagnose and manage various diseases associated with sympathetically maintained pain. Recently, numerous ultrasound (US)-assisted procedures in pain medicine have been attempted, showing an advantage of low radiation exposure. This randomized, prospective trial compared the procedural outcomes and complications between FL-guided and US-assisted LSGBs. METHODS: Fifty LSGBs were randomly divided into 2 groups: FL-guided (FL group) or US-assisted (US group) LSGB group...
November 17, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28979194/the-locus-coeruleus-norepinephrine-system-mediates-empathy-for-pain-through-selective-up-regulation-of-p2x3-receptor-in-dorsal-root-ganglia-in-rats
#4
Yun-Fei Lü, Yan Yang, Chun-Li Li, Yan Wang, Zhen Li, Jun Chen
Empathy for pain (vicariously felt pain), an ability to feel, recognize, understand and share the painful emotions of others, has been gradually accepted to be a common identity in both humans and rodents, however, the underlying neural and molecular mechanisms are largely unknown. Recently, we have developed a rat model of empathy for pain in which pain can be transferred from a cagemate demonstrator (CD) in pain to a naïve cagemate observer (CO) after 30 min dyadic priming social interaction. The naïve CO rats display both mechanical pain hypersensitivity (hyperalgesia) and enhanced spinal nociception...
2017: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/28973425/effects-and-safety-of-mechanical-bathing-as-a-complementary-therapy-for-terminal-stage-cancer-patients-from-the-physiological-and-psychological-perspective-a-pilot-study
#5
Sawako Fujimoto, Yoko Iwawaki, Yukie Takishita, Yoko Yamamoto, Masako Murota, Saori Yoshioka, Azusa Hayano, Toyoshi Hosokawa, Ryuya Yamanaka
Objective: In palliative care hospitals in Japan, mechanical bathing is conducted to maintain cleanliness. However, the physiological and psychological influence of mechanical bathing on patients has not been sufficiently studied. The objective of this study was to assess, using physiological and psychological indices, the effects of mechanical bathing care for patients in the terminal stage of cancer. Methods: Mechanical bathing was performed using a Marine Court SB7000 in a supine or semi-seated position...
August 30, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28859876/genetics-based-manipulation-of-adipose-tissue-sympathetic-innervation
#6
REVIEW
Marie François, Emily Qualls-Creekmore, Hans-Rudolf Berthoud, Heike Münzberg, Sangho Yu
There is renewed interest in leveraging the thermogenic capacity of brown adipose tissue (BAT) and browning of white adipose tissue (WAT) to improve energy balance and prevent obesity. In addition to these effects on energy expenditure, both BAT and WAT secrete large numbers of hormones and cytokines that play important roles in maintaining metabolic health. Both BAT and WAT are densely innervated by the sympathetic nervous system (SNS) and this innervation is crucial for BAT thermogenesis and WAT browning, making it a potentially interesting target for manipulating energy balance and treatment of obesity and metabolic disease...
August 30, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28479215/local-injection-to-sciatic-nerve-of-dexmedetomidine-reduces-pain-behaviors-sgcs-activation-ngf-expression-and-sympathetic-sprouting-in-cci-rats
#7
Jing-Ru Wu, Hui Chen, Ying-Ying Yao, Ming-Ming Zhang, Kai Jiang, Bo Zhou, Deng-Xin Zhang, Jie Wang
Neuropathic pain has become an intractable health threat, with its profound effect on quality of life. Dorsal root ganglia (DRG) is evidenced to play a crucial role in neuropathic pain. The peripheral nociceptive afferents seem to be essential not only to initiate the process of neuropathic pain, but also to maintain and modulate it. Dexmedetomidine (DEX), a highly selective agonist of α2-adrenergic receptor (α2-AR), has provided significant analgesia in neuropathic pain. In the present study, we found that local injection to sciatic nerve of DEX alleviated heat hypersensitivity induced by chronic constriction injury (CCI)...
June 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28466418/ambroxol-for-fibromyalgia-one-group-pretest-posttest-open-label-pilot-study
#8
Laura-Aline Martínez-Martínez, Luis-Fernando Pérez, Lizbeth-Teresa Becerril-Mendoza, Pedro Rodríguez-Henriquez, Omar-Eloy Muñoz, Gumaro Acosta, Luis H Silveira, Angélica Vargas, María-Isabel Barrera-Villalpando, Manuel Martínez-Lavín
A consistent line of investigation proposes that fibromyalgia is a sympathetically maintained neuropathic pain syndrome. Dorsal root ganglia sodium channels may play a major role in fibromyalgia pain transmission. Ambroxol is a secretolytic agent used in the treatment of various airway disorders. Recently, it was discovered that this compound is also an efficient sodium channel blocker with potent anti-neuropathic pain properties. We evaluated the add-on effect of ambroxol to the treatment of fibromyalgia. We studied 25 patients with fibromyalgia...
August 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28191693/gene-expression-profiles-in-peripheral-blood-mononuclear-cells-correlate-with-salience-network-activity-in-chronic-visceral-pain-a-pilot-study
#9
A Gupta, S Cole, J S Labus, S Joshi, T J Nguyen, L A Kilpatrick, K Tillisch, B D Naliboff, L Chang, E A Mayer
BACKGROUND: Distinct gene expression profiles in peripheral blood mononuclear cells (PBMCs) consistent with increased sympathetic nervous system activity have been described in different populations under chronic stress. Neuroinflammatory brain changes, possibly related to the migration of primed monocytes to the brain, have been implicated in the pathophysiology of chronic pain. Irritable bowel syndrome (IBS) is a stress-sensitive gastrointestinal disorder associated with altered brain-gut interactions and increased sympathetic/vagal tone and anxiety...
June 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/28119774/a-brief-report-on-a-technical-description-of-ultrasound-guided-lumbar-sympathetic-block
#10
Jee Youn Moon, Jae Kyu Choi, Ji Yeon Shin, Sung Won Chon, Sushmitha Dev
The lumbar sympathetic ganglion block (LSGB) is widely used for diagnosing and treating sympathetically maintained pain disorders. The LSGB has been conventionally carried out under fluoroscopy or computed tomography guidance. However, as ultrasound technology improved, ultrasound-guided interventions have been expanding their territory to deeper structures. Ultrasound guidance provides many benefits including protecting vascular injection, shortening procedure time in some cases, and reducing the emission of radiation...
January 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28097242/anterior-to-psoas-atp-fusion-of-the-lumbar-spine-evolution-of-a-technique-facilitated-by-changes-in-equipment
#11
Cristian Gragnaniello, Kevin Seex
BACKGROUND: Lateral interbody cages have been proven useful in spinal fusions. Spanning both lateral cortical rims while sparing the Anterior Longitudinal Ligament, the lateral interbody cages restore and maintain disc height while adding stability prior to supplemental fixation. The standard approach for their insertion is by a 90-degree lateral transpsoas method. This is relatively bloodless compared to other techniques although has its limitations, requiring neuro-monitoring and being, at times, very difficult at L4/5 due to iliac crest obstruction or an anterior plexus position...
December 2016: Journal of Spine Surgery (Hong Kong)
https://www.readbyqxmd.com/read/28072749/ultrasound-guided-pulsed-radiofrequency-treatment-of-the-cervical-sympathetic-chain-for-complex-regional-pain-syndrome-a-retrospective-observational-study
#12
Eung Don Kim, Woo Joo Yoo, Yoo Na Kim, Hue Jung Park
The stellate ganglion is a common target to manage neuropathic pain in the upper extremities. However, the effect duration of a single stellate ganglion block is often temporary. To overcome the short-term effects of a single sympathetic block, pulsed radiofrequency (PRF) can be applied. The aim of the present study was to investigate the efficacy of PRF on the cervical sympathetic chain under ultrasound guidance for complex regional pain syndrome (CRPS).Twelve CRPS patients who underwent PRF on the cervical sympathetic chain were enrolled in this retrospective analysis...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27535916/localized-sympathectomy-reduces-mechanical-hypersensitivity-by-restoring-normal-immune-homeostasis-in-rat-models-of-inflammatory-pain
#13
Wenrui Xie, Sisi Chen, Judith A Strong, Ai-Ling Li, Ian P Lewkowich, Jun-Ming Zhang
UNLABELLED: Some forms of chronic pain are maintained or enhanced by activity in the sympathetic nervous system (SNS), but attempts to model this have yielded conflicting findings. The SNS has both pro- and anti-inflammatory effects on immunity, confounding the interpretation of experiments using global sympathectomy methods. We performed a "microsympathectomy" by cutting the ipsilateral gray rami where they entered the spinal nerves near the L4 and L5 DRG. This led to profound sustained reductions in pain behaviors induced by local DRG inflammation (a rat model of low back pain) and by a peripheral paw inflammation model...
August 17, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27471314/clonidine-and-ketamine-for-stable-hemodynamics-in-off-pump-coronary-artery-bypass
#14
RANDOMIZED CONTROLLED TRIAL
Jigar Patel, Rajesh Thosani, Jignesh Kothari, Pankaj Garg, Himani Pandya
BACKGROUND: The current era of fast-track extubation and faster recovery after cardiac surgery requires agents that provide perioperative sedation, suppress sympathetic response, reduce opioid requirement, and maintain hemodynamic stability. METHODS: In a prospective randomized double-blind study, 75 off-pump coronary artery bypass patients were divided into 3 groups of 25 each: group A had clonidine 1 µg·kg(-1), group B had clonidine 1 µg·kg(-1) and ketamine 1 mg·kg(-1), and group C had a saline placebo...
September 2016: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/26777300/potential-role-of-estrogen-in-maintaining-the-imbalanced-sympathetic-and-sensory-innervation-in-endometriosis
#15
REVIEW
Yanchun Liang, Shuzhong Yao
Endometriosis, one of the most common benign gynecological diseases, affects millions of women of childbearing age. Endometriosis-associated pain is a major cause of disability and compromised quality of life in women. Neuropathic mechanisms are believed to play an important role. An imbalanced sympathetic and sensory innervation (reduced sympathetic innervation, with unchanged or increased sensory innervation in endometriotic lesions) has been demonstrated in endometriosis in recent studies. And it is believed to contribute to the pathogenesis of endometriosis-associated pain...
March 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/26581872/the-rostral-ventromedial-medulla-control-of-cutaneous-vasomotion-of-paws-and-tail-in-the-rat-implication-for-pain-studies
#16
Nabil El Bitar, Bernard Pollin, Gan Huang, André Mouraux, Daniel Le Bars
Thermal neutrality in rodents is achieved by large cyclic variations of the sympathetic drive of the vasomotion of the tail and paws, the most widely used target organs in current acute or chronic animal models of pain. Given the pivotal functional role of rostral ventromedial medulla (RVM) in nociception and rostral medullary raphe (rMR) in thermoregulation, two largely overlapping brain regions, we aimed at circumscribing the brainstem regions that are the source of premotor afferents to sympathetic preganglionic neurons that control the vasomotor tone of the tail and hind paws...
February 1, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/26557377/treatment-of-complex-regional-pain-syndrome-type-i-with-bisphosphonates
#17
REVIEW
Andrea Giusti, Gerolamo Bianchi
Complex regional pain syndrome type I (CRPS-I) is a common and disabling disorder affecting a peripheral limb, usually developing after a trauma to an extremity. CRPS-I is characterised by presence of spontaneous pain, allodynia and hyperalgesia, disproportionate to the inciting event and by a variety of autonomic disturbances and trophic abnormalities. The pathophysiology of CRPS-I has not been fully understood. Experimental models have suggested that an initial triggering event may produce the release of proinflammatory neuropeptides and cytokines, generating a sort of neurogenic inflammation...
2015: RMD Open
https://www.readbyqxmd.com/read/26240553/chronic-visceral-pain-secondary-to-ventral-disc-herniation-development-of-visceral-complex-regional-pain-syndrome
#18
Gabriela Rocha Lauretti, Raquel de Oliveira
When an organ disease is ruled out as the origin of pelvic pain, the superior hypogastric plexus (SHP) injury and consequent dysfunction could be the mechanism of visceral chronic pain perpetuation. As much as a dorsal discus herniation may harm the dorsal or ventral roots, a ventral discus herniation at L4-L5 or L5-S1 may result in direct physical trauma to the SHP, maintaining chronic visceral pain mediated by sympathetic dysfunction, conceivably also afferent fibers dysfunction. We propose that similarly to nociceptive somatic dysfunction named complex regional pain syndrome, the maintained sympathetic pelvic pain secondary to straight physical damage to the SHP characterize in fact the same disease, but in nociceptive visceral tissue, named visceral complex regional pain syndrome, a concept constructed based on the International Association for the Study of Pain criteria (1994)...
July 2015: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/26211335/-nerve-growth-factor-and-the-physiology-of-pain-the-relationships-among-interoception-sympathetic-neurons-and-the-emotional-response-indicated-by-the-molecular-pathophysiology-of-congenital-insensitivity-to-pain-with-anhidrosis
#19
REVIEW
Yasuhiro Indo
Nerve growth factor (NGF) is a neurotrophic factor essential for the survival and maintenance of neurons. Congenital insensitivity to pain with anhidrosis (CIPA) is caused by loss-of-function mutations in NTRK1, which encodes a receptor tyrosine kinase, TrkA, for NGF. Mutations in NTRK1 cause the selective loss of NGF-dependent neurons, including both NGF-dependent primary afferents and sympathetic postganglionic neurons, in otherwise intact systems. The NGF-dependent primary afferents are thinly myelinated AΔ or unmyelinated C-fibers that are dependent on the NGF-TrkA system during development...
May 2015: No to Hattatsu. Brain and Development
https://www.readbyqxmd.com/read/26136792/algodystrophy-recent-insight-into-the-pathogenic-framework
#20
REVIEW
Massimo Varenna, Francesca Zucchi
Algodystrophy, nowadays called CRPS I, is a painful syndrome characterized by sensory and vasomotor disturbance, edema and functional impairment. Significant progress in knowledge about the pathogenic mechanisms of the disease have been recently achieved, but they are not yet fully understood and some clinical aspects are still lacking of a whole pathogenetic comprehension. The local release of pro-inflammatory neuropeptides and some cytokines may be the event that triggers and maintains the disease, causing hyperalgesia and allodynia...
January 2015: Clinical Cases in Mineral and Bone Metabolism
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