keyword
MENU ▼
Read by QxMD icon Read
search

damage control AND colorectal

keyword
https://www.readbyqxmd.com/read/29142752/protective-effect-of-hydrogen-rich-water-on-liver-function-of-colorectal-cancer-patients-treated-with-mfolfox6-chemotherapy
#1
Qingxi Yang, Guangdong Ji, Rongtao Pan, Yinghui Zhao, Peng Yan
The present study was conducted to investigate the protective effect of hydrogen-rich water on the liver function of colorectal cancer (CRC) patients treated with mFOLFOX6 chemotherapy. A controlled, randomized, single-blind clinical trial was designed. A total of 152 patients with CRC were recruited by the Department of Oncology of Taishan Hospital (Taian, China) between June 2010 and February 2016, among whom 146 met the inclusion criteria. Subsequently, 144 patients were randomized into the treatment (n=80) and placebo (n=64) groups...
November 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29142293/neural-pathways-for-colorectal-control-relevance-to-spinal-cord-injury-and-treatment-a-narrative-review
#2
REVIEW
Brid Callaghan, John B Furness, Ruslan V Pustovit
STUDY DESIGN: Narrative review. OBJECTIVES: The purpose is to review the organisation of the nerve pathways that control defecation and to relate this knowledge to the deficits in colorectal function after SCI. METHODS: A literature review was conducted to identify salient features of defecation control pathways and the functional consequences of damage to these pathways in SCI. RESULTS: The control pathways for defecation have separate pontine centres under cortical control that influence defecation...
November 16, 2017: Spinal Cord
https://www.readbyqxmd.com/read/29113173/bioinformatics-analysis-of-srsf1-controlled-gene-networks-in-colorectal-cancer
#3
Junxiu Sheng, Jinyao Zhao, Qiuhong Xu, Linlin Wang, Wenjing Zhang, Yang Zhang
Colorectal cancer is the third most common type of cancer and the fourth leading cause of cancer-associated mortality worldwide. Serine/arginine-rich splicing factor 1 (SRSF1) is a well-characterized oncogenic factor that promotes tumorigenesis by controlling a number of alternative splicing events. However, there is limited network analysis, from a global aspect, to study the effect of SRSF1 on colorectal cancer. In the present study, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of available gene regulation data from The Cancer Genome Atlas database revealed the enriched functions and signaling pathways of SRSF1...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29068374/ameliorative-effect-of-caffeic-acid-on-capecitabine-induced-hepatic-and-renal-dysfunction-involvement-of-the-antioxidant-defence-system
#4
Ebenezer Tunde Olayinka, Olaniyi Solomon Ola, Ayokanmi Ore, Oluwatobi Adewumi Adeyemo
Background: It has been postulated that during liver and kidney damage there is a decreased in the antioxidant status associated with a simultaneous increase in the reactive oxygen species and lipid peroxidation. In consonant with this, Capecitabine, an oral chemotherapy and inactive non-cytotoxic fluoropyrimidine considered for the treatment of advance colorectal cancer, has also been shown to induce oxidative stress in liver tissues. Caffeic acid, a typical hydroxycinnamic, has been claimed to be effective against oxidative stress...
October 25, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/29052312/bleomycin-induced-chromosomal-damage-and-shortening-of-telomeres-in-peripheral-blood-lymphocytes-of-incident-cancer-patients
#5
Michal Kroupa, Zdenka Polivkova, Sivaramakrishna Rachakonda, Michaela Schneiderova, Sona Vodenkova, Tomas Buchler, Katerina Jiraskova, Marketa Urbanova, Ludmila Vodickova, Kari Hemminki, Rajiv Kumar, Pavel Vodicka
Disruption of genomic integrity due to deficient DNA repair capacity and telomere shortening constitute hallmarks of malignant diseases. Incomplete or deficient repair of DNA double-strand breaks (DSB) is manifested by chromosomal aberrations (CAs) and their frequency reflects inter-individual differences of response to exposure to mutagenic compounds. In this study, we investigated chromosomal integrity in peripheral blood lymphocytes (PBL) from newly diagnosed cancer patients, including 47 breast (BC) and 44 colorectal cancer (CRC) patients and 90 matched healthy controls...
October 20, 2017: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/29028286/doppler-guided-goal-directed-fluid-therapy-does-not-affect-intestinal-cell-damage-but-increases-global-gastrointestinal-perfusion-in-colorectal-surgery-a-randomized-controlled-trial
#6
Kostan W Reisinger, Henriette M Willigers, Jochen Jansen, Wim A Buurman, Maarten F Von Meyenfeldt, Geerard L Beets, Martijn Poeze
Individualized, goal-directed fluid therapy (GDFT) based on Doppler measurements of stroke volume has been proposed as a treatment strategy in terms of reducing complications, mortality and length of hospital stay in major bowel surgery. We studied the effect of Doppler guided GDFT on intestinal damage as compared with standard post-operative fluid replacement. STUDY DESIGN: Patients undergoing elective colorectal resection for malignancy were randomized to standard intra- and postoperative fluid therapy or standard fluid therapy with additional Doppler guided GDFT...
October 13, 2017: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/28986187/aldose-reductase-inhibitor-fidarestat-regulates-mitochondrial-biogenesis-via-nrf2-ho-1-ampk-pathway-in-colon-cancer-cells
#7
Kirtikar Shukla, Himangshu Sonowal, Ashish Saxena, Kota V Ramana, Satish K Srivastava
Although we have shown earlier that aldose reductase (AR) inhibitors prevent colorectal cancer cell (CRC) growth in culture as well as in nude mice xenografts, the mechanism(s) is not well understood. In this study, we have investigated how AR inhibition prevents CRC growth by regulating the mitochondrial biogenesis via Nrf2/HO-1 pathway. Incubation of CRC cells such as SW-480, HT29, and HCT116 with AR inhibitor, fidarestat that non-covalently binds to the enzyme, increases the expression of Nrf2. Further, fidarestat augmented the EGF-induced expression of Nrf2 in CRC cells...
October 3, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28872077/-role-of-ppix-based-photodynamic-therapy-in-promoting-the-damage-and-apoptosis-of-colorectal-cancer-cell-and-its-mechanisms
#8
Guoqing Ouyang, Zhipeng Liu, Li Xiong, Xiang Chen, Qinglong Li, He Huang, Liangwu Lin, Xiongying Miao, Lun Ma, Wei Chen, Yu Wen
To explore the effects of protoporphyrin IX (PpIX)-mediated photodynamic therapy (PDT) on induction of apoptosis and death in colon cancer cell and the underlying mechanisms.
 Methods: The cell killing effect of PDT on HCT116 cell was determined by cell counting kit (CCK). The cells were divided into a control group, a single light group, a single PpIX group, and a PDT group. Hoechst 33342 and flow cytometry was used to assess the cell apoptosis. Western blot was employed to analyze the expressions of bcl-2, bax, and caspase-3...
August 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28859095/exacerbation-of-colon-carcinogenesis-by-blastocystis-sp
#9
Vinoth Kumarasamy, Umah Rani Kuppusamy, Pailoor Jayalakshmi, Chandramathi Samudi, Nanthiney Devi Ragavan, Suresh Kumar
Colorectal cancer (CRC) is one the most commonly diagnosed cancers worldwide and the number is increasing every year. Despite advances in screening programs, CRC remains as the second leading cause of cancer deaths in the United States. Oxidative stress plays an important role in the molecular mechanisms of colorectal cancer (CRC) and has been shown to be associated with Blastocystis sp., a common intestinal microorganism. In the present study, we aimed to identify a role for Blastocystis sp. in exacerbating carcinogenesis using in vivo rat model...
2017: PloS One
https://www.readbyqxmd.com/read/28846497/the-efficacy-of-a-novel-surgical-device-in-preventing-intraoperative-wound-contamination-in-an-in-vivo-porcine-model
#10
Insoo Suh, Sarah A Long, Jonathan Coe, Jeremy Koehler, Donald Fry, Mark L Welton
BACKGROUND: Surgical site infections (SSIs) remain a morbid and costly complication in abdominal surgery. Topical antibiotic delivery via intraoperative irrigation and barrier wound protection are strategies for preventing SSI. We tested the safety and efficacy of a novel wound protector device with an integrated fluid irrigation platform in a porcine model. METHODS: A simulated colorectal resection model was designed and performed on adult female pigs with a standardized concentration of 10(9) colony-forming units (CFU) of Escherichia coli administered to the wound site in 10 mL of normal saline (n = 7)...
August 28, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28737782/ferrocene-cinchona-hybrids-with-triazolyl-chalcone-linkers-act-as-pro-oxidants-and-sensitize-human-cancer-cell-lines-to-paclitaxel
#11
Ana Podolski-Renić, Szilvia Bősze, Jelena Dinić, László Kocsis, Ferenc Hudecz, Antal Csámpai, Milica Pešić
Recently, we demonstrated that ferrocene-containing compounds with a cinchona moiety displayed marked anticancer activity. Here we report on the effects of the most promising isomers encompassing quinine- (compounds 4 and 5) and quinidine-epimers (compounds 6 and 7) - synthesized using improved methods providing controlled diastereoselectivity - in three different human multidrug resistant (MDR) cancer cell lines and their sensitive counterparts (non-small cell lung carcinoma NCI-H460/R/NCI-H460, colorectal carcinoma DLD1-TxR/DLD1 and glioblastoma U87-TxR/U87)...
August 16, 2017: Metallomics: Integrated Biometal Science
https://www.readbyqxmd.com/read/28708932/tandem-repeat-variation-near-the-hic1-hypermethylated-in-cancer-1-promoter-predicts-outcome-of-oxaliplatin-based-chemotherapy-in-patients-with-metastatic-colorectal-cancer
#12
Satoshi Okazaki, Marta Schirripa, Fotios Loupakis, Shu Cao, Wu Zhang, Dongyun Yang, Yan Ning, Martin D Berger, Yuji Miyamoto, Mitsukuni Suenaga, Syma Iqubal, Afsaneh Barzi, Chiara Cremolini, Alfredo Falcone, Francesca Battaglin, Lisa Salvatore, Beatrice Borelli, Timothy G Helentjaris, Heinz-Josef Lenz
BACKGROUND: The hypermethylated in cancer 1/sirtuin 1 (HIC1/SIRT1) axis plays an important role in regulating the nucleotide excision repair pathway, which is the main oxaliplatin-induced damage-repair system. On the basis of prior evidence that the variable number of tandem repeat (VNTR) sequence located near the promoter lesion of HIC1 is associated with HIC1 gene expression, the authors tested the hypothesis that this VNTR is associated with clinical outcome in patients with metastatic colorectal cancer who receive oxaliplatin-based chemotherapy...
November 15, 2017: Cancer
https://www.readbyqxmd.com/read/28705917/curative-multicycle-radioimmunotherapy-monitored-by-quantitative-spect-ct-based-theranostics-using-bispecific-antibody-pretargeting-strategy-in-colorectal-cancer
#13
Sarah M Cheal, Edward K Fung, Mitesh Patel, Hong Xu, Hong-Fen Guo, Pat B Zanzonico, Sebastien Monette, K Dane Wittrup, Nai-Kong V Cheung, Steven M Larson
Radioimmunotherapy of solid tumors using antibody-targeted radionuclides has been limited by low therapeutic indices (TIs). We recently reported a novel 3-step pretargeted radioimmunotherapy (PRIT) strategy based on a glycoprotein A33 (GPA33)-targeting bispecific antibody and a small-molecule radioactive hapten, a complex of (177)Lu and S-2-(4-aminobenzyl)-1,4,7,10-tetraazacyclododecane tetraacetic acid ((177)Lu-DOTA-Bn), that leads to high TIs for radiosensitive tissues such as blood (TI = 73) and kidney (TI = 12)...
November 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28642718/irinotecan-induced-gastrointestinal-dysfunction-is-associated-with-enteric-neuropathy-but-increased-numbers-of-cholinergic-myenteric-neurons
#14
Rachel M McQuade, Vanesa Stojanovska, Elizabeth L Donald, Ahmed A Rahman, Dean G Campelj, Raquel Abalo, Emma Rybalka, Joel C Bornstein, Kulmira Nurgali
Gastrointestinal dysfunction is a common side-effect of chemotherapy leading to dose reductions and treatment delays. These side-effects may persist up to 10 years post-treatment. A topoisomerase I inhibitor, irinotecan (IRI), commonly used for the treatment of colorectal cancer, is associated with severe acute and delayed-onset diarrhea. The long-term effects of IRI may be due to damage to enteric neurons innervating the gastrointestinal tract and controlling its functions. Balb/c mice received intraperitoneal injections of IRI (30 mg/kg(-1)) 3 times a week for 14 days, sham-treated mice received sterile water (vehicle) injections...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28638341/herbal-medicine-ac591-prevents-oxaliplatin-induced-peripheral-neuropathy-in-animal-model-and-cancer-patients
#15
Xiaolan Cheng, Jiege Huo, Dawei Wang, Xueting Cai, Xiaoyan Sun, Wuguang Lu, Yang Yang, Chunping Hu, Xiaoning Wang, Peng Cao
Oxaliplatin is clinically compelling because of severe peripheral neuropathy. The side effect can result in dosage reductions or even cessation of chemotherapy, and no effective treatments are available. AC591 is a standardized extract of Huangqi Guizhi Wuwu decoction, an herbal formula recorded in "Synopsis of the Golden Chamber" for improving limb numbness and pain. In this study, we investigated whether AC591 could protect against oxaliplatin-induced peripheral neuropathy. To clarify it, a rat model of oxaliplatin-induced peripheral neuropathy was established, and neuroprotective effect of AC591 was studied...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28625152/lipid-oxidation-products-in-the-pathogenesis-of-inflammation-related-gut-diseases
#16
Barbara Sottero, Daniela Rossin, Giuseppe Poli, Fiorella Biasi
A defective mucosal barrier function is the principal cause of the uncontrolled onset and progression of a number of human inflammatory gut diseases, most of which are characterized by chronic intermittent immune and inflammatory responses leading to structural intestinal damage, which can represent a potential risk for colorectal cancer development. During the active disease phase the production of pro-inflammatory cytokines and chemokines, and the induction of oxidative reactions by activated leukocytes and epithelial cells represent the main event in intestinal inflammation...
June 19, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/28598238/nlrc3-regulates-cellular-proliferation-and-apoptosis-to-attenuate-the-development-of-colorectal-cancer
#17
Rajendra Karki, R K Subbarao Malireddi, Qifan Zhu, Thirumala-Devi Kanneganti
Nucleotide-binding domain, leucine-rich-repeat-containing proteins (NLRs) are intracellular innate immune sensors of pathogen-associated and damage-associated molecular patterns. NLRs regulate diverse biologic processes such as inflammatory responses, cell proliferation and death, and gut microbiota to attenuate tumorigenesis. In a recent publication in Nature, we identified NLRC3 as a negative regulator of PI3K-mTOR signaling and characterized its potential tumor suppressor function. Enterocytes lacking NLRC3 cannot control cellular proliferation because they are unable to suppress activation of PI3K-mTOR signaling pathways...
July 3, 2017: Cell Cycle
https://www.readbyqxmd.com/read/28545907/impact-of-chemotherapy-on-gastrointestinal-functions-and-the-enteric-nervous-system
#18
REVIEW
Jonathan Escalante, Rachel M McQuade, Vanesa Stojanovska, Kulmira Nurgali
Chemotherapy is the main treatment for many cancers, including colorectal cancer, a type of cancer with some of the highest prevalence and mortality rates worldwide. Although chemotherapeutic drugs have greatly improved the survival rates of cancer patients, there are many side-effects associated with their use. The gastrointestinal side-effects of chemotherapy often lead to dose reduction or even discontinuation of treatment, which in turn affects the clinical outcome. Gastrointestinal side-effects, such as chemotherapy-induced diarrhea and constipation, may persist many years after treatment, greatly reducing quality of life...
May 10, 2017: Maturitas
https://www.readbyqxmd.com/read/28497404/sexual-dysfunction-following-rectal-cancer-surgery
#19
REVIEW
V Celentano, R Cohen, J Warusavitarne, O Faiz, M Chand
INTRODUCTION: Sexual and urological problems after surgery for rectal cancer are common, multifactorial, inadequately discussed, and untreated. The urogenital function is dependent on dual autonomic sympathetic and parasympathetic innervation, and four key danger zones exist that are at risk for nerve damage during colorectal surgery: one of these sites is in the abdomen and three are in the pelvis. The aim of this study is to systematically review the epidemiology of sexual dysfunction following rectal cancer surgery, to describe the anatomical basis of autonomic nerve-preserving techniques, and to explore the scientific evidence available to support the laparoscopic or robotic approach over open surgery...
May 11, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28437458/isomalto-oligosaccharides-ameliorate-visceral-hyperalgesia-with-repair-damage-of-ileal-epithelial-ultrastructure-in-rats
#20
Weida Wang, Haiwei Xin, Xiucai Fang, Hongtao Dou, Fangyi Liu, Dan Huang, Shaomei Han, Guijun Fei, Liming Zhu, Shenghua Zha, Hong Zhang, Meiyun Ke
BACKGROUND: Treatment of irritable bowel syndrome (IBS) with probiotics has achieved effectiveness to a certain extent. Whether prebiotics will work is still unclear. This study aimed to investigate the therapeutic effects of the prebiotic isomalto-oligosaccharides (IMO) on visceral hypersensitivity (VHS) in rats and to explore potential mechanism. METHODS: Water avoidance stress (WAS) was used to induce VHS in rats. The score for the abdominal withdrawal reflex (AWR) was determined while colorectal distension and compared between VHS group and control group in order to validate VHS preparation...
2017: PloS One
keyword
keyword
57738
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"