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https://www.readbyqxmd.com/read/29154420/relationship-between-skeletal-muscle-mass-and-cardiac-function-during-exercise-in-community-dwelling-older-adults
#1
Masamitsu Sugie, Kazumasa Harada, Tetsuya Takahashi, Marina Nara, Joji Ishikawa, Teruyuki Koyama, Hunkyung Kim, Jun Tanaka, Hajime Fujimoto, Shuichi Obuchi, Stephan von Haehling, Syunei Kyo, Hideki Ito
AIMS: This study aimed to investigate the relationship between skeletal muscle mass and cardiac functional parameters in older adults during cardiopulmonary exercise testing (CPET). METHODS AND RESULTS: Sixty-three Japanese community-dwelling older adults were enrolled (20 men and 43 women; mean age 80 years, range 65-97 years). Cardiac functional parameters during exercise were assessed using CPET. Skeletal muscle mass index (SMI) was calculated by dividing the appendicular lean mass (measured using dual-energy X-ray absorptiometry) by height in metres squared...
November 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/29153940/tumor-derived-cytokines-impair-myogenesis-and-alter-the-skeletal-muscle-immune-microenvironment
#2
Kelly A Hogan, Dong Seong Cho, Paige C Arneson, Adrienne Samani, Patrick Palines, Yanan Yang, Jason D Doles
Muscle wasting is a decline in skeletal muscle mass and function that is associated with aging, obesity, and a spectrum of pathologies including cancer. Cancer-associated wasting not only reduces quality of life, but also directly impacts cancer mortality, chemotherapeutic efficacy, and surgical outcomes. There is an incomplete understanding of the role of tumor-derived factors in muscle wasting and sparse knowledge of how these factors impact in vivo muscle regeneration. Here, we identify several cytokines/chemokines that negatively impact in vitro myogenic differentiation...
November 16, 2017: Cytokine
https://www.readbyqxmd.com/read/29151827/tumor-necrosis-factor-like-weak-inducer-of-apoptosis-regulates-quadriceps-muscle-atrophy-and-fiber-type-alteration-in-a-rat-model-of-chronic-obstructive-pulmonary-disease
#3
Jun-Juan Lu, Qing Wang, Li Hua Xie, Qiang Zhang, Sheng Hua Sun
Background: In chronic obstructive pulmonary disease (COPD), weakness and muscle mass loss of the quadriceps muscle has been demonstrated to predict survival and mortality rates of patients. Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK), as a member of the TNF superfamily, has recently been identified as a key regulator of skeletal muscle wasting and metabolic dysfunction. So our aim was to study the role of TWEAK during quadriceps muscle atrophy and fiber-type transformation in COPD model rats and its possible pathway...
2017: Tobacco Induced Diseases
https://www.readbyqxmd.com/read/29151281/skeletal-muscle-performance-and-ageing
#4
REVIEW
Michael Tieland, Inez Trouwborst, Brian C Clark
The world population is ageing rapidly. As society ages, the incidence of physical limitations is dramatically increasing, which reduces the quality of life and increases healthcare expenditures. In western society, ~30% of the population over 55 years is confronted with moderate or severe physical limitations. These physical limitations increase the risk of falls, institutionalization, co-morbidity, and premature death. An important cause of physical limitations is the age-related loss of skeletal muscle mass, also referred to as sarcopenia...
November 19, 2017: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/29149975/clinical-outcomes-of-living-liver-transplantation-according-to-the-presence-of-sarcopenia-as-defined-by-skeletal-muscle-mass-hand-grip-and-gait-speed
#5
N Harimoto, T Yoshizumi, T Izumi, T Motomura, N Harada, S Itoh, T Ikegami, H Uchiyama, Y Soejima, A Nishie, T Kamishima, R Kusaba, K Shirabe, Y Maehara
BACKGROUND: Sarcopenia is an independent predictor of death after living-donor liver transplantation (LDLT). However, the ability of the Asian Working Group for Sarcopenia criteria for sarcopenia (defined as reduced skeletal muscle mass plus low muscle strength) to predict surgical outcomes in patients who have undergone LDLT has not been determined. METHODS: This study prospectively enrolled 366 patients who underwent LDLT at Kyushu University Hospital. Skeletal muscle area (determined by computed tomography), hand-grip strength, and gait speed were measured in 102 patients before LDLT...
November 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/29147870/changes-in-body-composition-and-muscle-attenuation-during-taxane-based-chemotherapy-in-patients-with-metastatic-breast-cancer
#6
Hánah N Rier, Agnes Jager, Stefan Sleijfer, Joost van Rosmalen, Marc C J M Kock, Mark-David Levin
PURPOSE: Body composition parameters including low muscle mass, muscle attenuation (which reflects muscle quality) and adipose tissue measurements have emerged as prognostic factors in cancer patients. However, knowledge regarding the possibility of excessive muscle loss during specific systemic therapies is unknown. We describe the changes in body composition and muscle attenuation (MA) during taxane- and anthracycline-based regimens and its association with overall survival (OS) in metastatic breast cancer patients...
November 17, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29141949/microvascular-insulin-resistance-in-skeletal-muscle-and-brain-occurs-early-in-the-development-of-juvenile-obesity-in-pigs
#7
T Dylan Olver, Zachary Ian Grunewald, Thomas J Jurrissen, Rebecca Ek MacPherson, Paul J LeBlanc, Teagan R Schnurbusch, Alana M Czajkowski, Maurice Harold Laughlin, R Scott Rector, Shawn B Bender, Eric M Walters, Craig A Emter, Jaume Padilla
BACKGROUND: Impaired microvascular insulin signaling may develop prior to overt indices of microvascular endothelial dysfunction and represent an early pathological feature of adolescent obesity. Using a translational porcine model of juvenile obesity, we tested the hypotheses that in the early stages of obesity development, impaired insulin signaling manifests in skeletal muscle (triceps), brain (prefrontal cortex) and corresponding vasculatures, and that depressed insulin-induced vasodilation is reversible with acute inhibition of protein kinase C beta (PKCβ)...
November 15, 2017: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29141602/association-between-sarcopenia-and-low-back-pain-in-local-residents-prospective-cohort-study-from-the-gaina-study
#8
Shinji Tanishima, Hiroshi Hagino, Hiromi Matsumoto, Chika Tanimura, Hideki Nagashima
BACKGROUND: Low back pain (LBP) is one of the most common ailments that people experience in their lifetime. On the other hands, Sarcopenia also leads to several physical symptoms and contributes to reducing the quality of life of elderly people.The purpose of this study is to investigate the association between sarcopenia and low back pain among the general population. METHODS: The subjects included 216 adults (79 men and 137 women; mean age, 73.5 years) undergoing a general medical examination in Hino, Japan...
November 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29140739/cftr-genotype-and-maximal-exercise-capacity-in-cystic-fibrosis-a-cross-sectional-study
#9
Thomas Radtke, Helge Hebestreit, Sabina Gallati, Jane E Schneiderman, Julia Braun, Daniel Stevens, Erik Hj Hulzebos, Tim Takken, Steven R Boas, Don S Urquhart, Larry C Lands, Sergio Tejero, Aleksandar Sovtic, Tiffany Dwyer, Milos Petrovic, Ryan A Harris, Chantal Karila, Daniela Savi, Jakob Usemann, Meir Mei-Zahav, Elpis Hatziagorou, Felix Ratjen, Susi Kriemler
RATIONALE: Cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in human skeletal muscle cells. Variations of CFTR dysfunction among patients with CF may present an important determinant of aerobic exercise capacity in CF. Previous studies on the relationship between CFTR genotype and aerobic exercise capacity are scarce and contradictory. OBJECTIVES: This study was designed to explore factors influencing aerobic exercise capacity, expressed as peak oxygen consumption (VO2peak) with a specific focus on CFTR genotype in children and adults with CF...
November 15, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29139618/beyond-sarcopenia-characterization-and-integration-of-skeletal-muscle-quantity-and-radiodensity-in-a-curable-breast-cancer-population
#10
Marc S Weinberg, Shlomit S Shachar, Hyman B Muss, Allison M Deal, Karteek Popuri, Hyeon Yu, Kirsten A Nyrop, Shani M Alston, Grant R Williams
Skeletal muscle loss, commonly known as sarcopenia, is highly prevalent and prognostic of adverse outcomes in oncology. However, there is limited information on adults with early breast cancer and examination of other skeletal muscle indices, despite the potential prognostic importance. This study characterizes and examines age-related changes in body composition of adults with early breast cancer and describes the creation of a novel integrated muscle measure. Female patients diagnosed with stage I-III breast cancer with abdominal computerized tomography (CT) scans within 12 weeks from diagnosis were identified from local tumor registry (N = 241)...
November 15, 2017: Breast Journal
https://www.readbyqxmd.com/read/29139392/-myonuclear-domain-and-microtubule-proteome-during-skeletal-muscle-maturation
#11
Nathalie Couturier, Vincent Gache
In the normal course of muscle fiber development, myonuclei actively position and adapt a precise localization in mature fibers, shaping MyoNuclear Domains (MNDs). Myonuclei positioning in fibers appears to be essential for muscle function as defects in MNDs settings are always associated with dysfunction (i.e., centronuclear myopathy, sarcopenia). Previous studies have shown that myonuclei positioning in fibers is reversible, suggesting that in pathologies presenting MNDs impairment, myonuclei could be re-addressed to the "correct" position in fibers and this could benefit to muscle function...
November 2017: Médecine Sciences: M/S
https://www.readbyqxmd.com/read/29137032/non-hodgkin-lymphoma-of-multiple-extranodal-involvement-seen-on-mri-fdg-pet-ct-scans-a-case-report
#12
Shan Wang, Meng Meng, Qiuhu Wang, Kai Xu
RATIONALE: Anaplastic large cell lymphoma (ALCL) is a rare type of non-Hodgkin lymphoma (NHL). The most common extranodal sites of ALCL are skin, subcutaneous tissue, bone, lung, and gastrointestinal organs. This study reports a case of ALCL with multiple extranodal involvement, especially the whole body skeletal muscles, with the aim to share the imaging features of the ALCL including magnetic resonance imaging (MRI) and 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29131558/cytologic-findings-of-an-adult-rhabdomyoma-in-the-parapharyngeal-space-a-report-of-a-case-and-review-of-the-literature
#13
Josephine Kamtai Dermawan, Erika Doxtader, Deborah J Chute, Maria Luisa Policarpio-Nicolas
Adult extracardiac rhabdomyomas are rare benign mesenchymal tumor arising from skeletal muscle. While they are often located in the larynx and pharynx, the incidence in the parapharyngeal area is extremely rare with only 1 documented cytology case report to date. We report a case of an adult extracardiac rhabdomyoma in the parapharyngeal space diagnosed cytologically with subsequent histologic confirmation. The patient is a 57-year-old man with history of weight loss, hematuria, dysphagia, and airway encroachment...
November 12, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/29130969/mechanistic-links-underlying-the-impact-of-c-reactive-protein-on-muscle-mass-in-elderly
#14
Britta Wåhlin-Larsson, Daniel J Wilkinson, Emelie Strandberg, Adrian Hosford-Donovan, Philip J Atherton, Fawzi Kadi
BACKGROUND/AIMS: Mechanisms underlying the relationship between systemic inflammation and age-related decline in muscle mass are poorly defined. The purpose of this work was to investigate the relationship between the systemic inflammatory marker CRP and muscle mass in elderly and to identify mechanisms by which CRP mediates its effects on skeletal muscle, in-vitro. METHODS: Muscle mass and serum CRP level were determined in a cohort of 118 older women (67±1.7 years)...
November 9, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29130720/-relationship-between-quality-of-life-physical-activity-nutrition-glycemic-control-and-sarcopenia-in-older-adults-with-type-2-diabetes-mellitus
#15
Cristina Casals-Vázquez, Ernesto Suárez-Cadenas, Francisca María Estébanez Carvajal, María Pilar Aguilar Trujillo, María M Jiménez Arcos, María Ángeles Vázquez Sáchez
INTRODUCTION: The term sarcopenia is defined as age-related loss of skeletal muscle mass and function, with a consequent impact on quality of life. However, there is a lack of studies examining the prevalence of sarcopenia in patients with type 2 diabetes mellitus (DM). OBJECTIVES: To analyze the prevalence of sarcopenia in patients over 65 years with type 2 DM and the influence of physical activity, diet, glycemic control, sex, age, and quality of life. METHODS: A total of 279 patients (155 females), aged 76...
October 24, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29129228/preoperative-low-muscle-mass-has-a-strong-negative-effect-on-pulmonary-function-in-patients-undergoing-living-donor-liver-transplantation
#16
Hisaya Shirai, Toshimi Kaido, Yuhei Hamaguchi, Siyuan Yao, Atsushi Kobayashi, Shinya Okumura, Naoko Kamo, Shintaro Yagi, Hideaki Okajima, Shinji Uemoto
OBJECTIVE: This study investigated the effect of preoperative sarcopenia on cardiopulmonary function in patients undergoing living donor liver transplantation (LDLT). METHODS: A retrospective analysis was performed of 207 patients who underwent LDLT between January 2008 and April 2015. The quantity and quality of skeletal muscle were evaluated by the psoas muscle mass index (PMI) and intramuscular adipose tissue content (IMAC), respectively, using preoperative computed tomography imaging...
January 2018: Nutrition
https://www.readbyqxmd.com/read/29127513/pentosidine-concentration-is-associated-with-degenerative-lumbar-scoliosis-in-older-women-preliminary-results
#17
Yawara Eguchi, Toru Toyoguchi, Kazuhide Inage, Kazuki Fujimoto, Sumihisa Orita, Kazuyo Yamauchi, Miyako Suzuki, Hirohito Kanamoto, Koki Abe, Masaki Norimoto, Tomotaka Umimura, Masao Koda, Takeo Furuya, Yasuchika Aoki, Kazuhisa Takahashi, Seiji Ohtori
PURPOSE: Advanced glycation end products (AGEs) have been implicated in the pathogenesis of sarcopenia. The objective of the study was to investigate the prevalence of sarcopenia in degenerative lumbar scoliosis (DLS), and the relationship between biochemical markers including major AGEs, pentosidine, and DLS in older women. METHODS: Our study participants were 20 elderly women with idiopathic DLS (mean age 76.4 years, range 56-88). Nineteen age- and sex-matched volunteers (mean age 74...
November 10, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29127187/apobec2-deficiency-causes-mitochondrial-defects-and-mitophagy-in-skeletal-muscle
#18
Yusuke Sato, Hideaki Ohtsubo, Naohiro Nihei, Takane Kaneko, Yoriko Sato, Shin-Ichi Adachi, Shinji Kondo, Mako Nakamura, Wataru Mizunoya, Hiroshi Iida, Ryuichi Tatsumi, Cristina Rada, Fumiaki Yoshizawa
Apobec2 is a member of the activation-induced deaminase/apolipoprotein B mRNA editing enzyme catalytic polypeptide cytidine deaminase family expressed in differentiated skeletal and cardiac muscle. We previously reported that Apobec2 deficiency in mice leads to a shift in muscle fiber type, myopathy, and diminished muscle mass. However, the mechanisms of myopathy caused by Apobec2 deficiency and its physiologic functions are unclear. Here we show that, although Apobec2 localizes to the sarcomeric Z-lines in mouse tissue and cultured myotubes, the sarcomeric structure is not affected in Apobec2-deficient muscle...
November 10, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29127005/the-pleckstrin-homology-like-domain-family-member-tdag51-is-temporally-regulated-during-skeletal-muscle-regeneration
#19
Samantha K Coleman, Andrew W Cao, Irena A Rebalka, Gabriel Gyulay, Paige J Chambers, A Russell Tupling, Richard C Austin, Thomas J Hawke
The capacity for skeletal muscle to repair from daily insults as well as larger injuries is a vital component to maintaining muscle health over our lifetime. Given the importance of skeletal muscle for our physical and metabolic well-being, identifying novel factors mediating the growth and repair of skeletal muscle will thus build our foundational knowledge and help lead to potential therapeutic avenues for muscle wasting disorders. To that end, we investigated the expression of T-cell death associated gene 51 (TDAG51) during skeletal muscle repair and studied the response of TDAG51 deficient (TDAG51(-/-)) mice to chemically-induced muscle damage...
November 7, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29125205/reconstructing-pectoral-appendicular-muscle-anatomy-in-fossil-fish-and-tetrapods-over-the-fins-to-limbs-transition
#20
Julia L Molnar, Rui Diogo, John R Hutchinson, Stephanie E Pierce
The question of how tetrapod limbs evolved from fins is one of the great puzzles of evolutionary biology. While palaeontologists, developmental biologists, and geneticists have made great strides in explaining the origin and early evolution of limb skeletal structures, that of the muscles remains largely unknown. The main reason is the lack of consensus about appendicular muscle homology between the closest living relatives of early tetrapods: lobe-finned fish and crown tetrapods. In the light of a recent study of these homologies, we re-examined osteological correlates of muscle attachment in the pectoral girdle, humerus, radius, and ulna of early tetrapods and their close relatives...
November 10, 2017: Biological Reviews of the Cambridge Philosophical Society
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