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Shijiang Liu, Yangjie Li, Cheng Zhang, Liang Yang, Tingting Zhao, Ruilong Zhang, Changlong Jiang
Ratiometric fluorescence sensor exhibits advantages of sensitive response, high anti-interference ability and naked eye visualization owing to multiple independent emission peaks utilized for results analysis. To achieve such multi-emission probe, the traditional methods have involved simple mixing of two emitters or tedious synthesis processes of hybrid material. However, these probes often have problems of inconstant emission strength ratio, low light-stability, and complicated synthetic process, which limit their applications in practical field...
January 7, 2017: Journal of Colloid and Interface Science
Paolo Fattorini, Carlo Previderé, Ilaria Carboni, Giorgio Marrubini, Solange Sorçaburu-Cigliero, Pierangela Grignani, Barbara Bertoglio, Paolo Vatta, Ugo Ricci
Next generation sequencing (NGS) is the emerging technology in forensic genomics laboratories. It offers higher resolution to address most problems of human identification, greater efficiency and potential ability to interrogate very challenging forensic casework samples. In the present study, a trial set of DNA samples was artificially degraded, by progressive aqueous hydrolysis, and analyzed together with the corresponding unmodified DNA sample and control sample 2800M, to test the performance and reliability of the ForenSeq(TM) DNA Signature Prep kit using the MiSeq Sequencer (Illumina)...
January 12, 2017: Electrophoresis
Yoshiharu Ohno, Takeshi Yoshikawa, Yuji Kishida, Shinichiro Seki, Nevzat Karabulut
OBJECTIVE: This article discusses the basics of unenhanced MR angiography (MRA) and MR venography (MRV), time-resolved contrast-enhanced (CE) MRA and dynamic first-pass CE perfusion MRI, and unenhanced and CE MRV, in addition to assessing the clinical relevance of these techniques for evaluating patients with suspected pulmonary thromboembolism and deep venous thrombosis. CONCLUSION: Since the 1990s, the efficacy of MRA or MRV and dynamic perfusion MRI for patients with suspected pulmonary thromboembolism and deep venous thrombosis has been evaluated...
January 11, 2017: AJR. American Journal of Roentgenology
Christian Nienberg, Claudia Garmann, Andreas Gratz, Andre Bollacke, Claudia Götz, Joachim Jose
Human protein kinase CK2 has emerged as promising target for the treatment of neoplastic diseases. The vast majority of kinase inhibitors known today target the ATP binding site, which is highly conserved among kinases and hence leads to limited selectivity. In order to identify non-ATP competitive inhibitors, a 12-mer peptide library of 6 × 10⁵ variants was displayed on the surface of E. coli by autodisplay. Screening of this peptide library on variants with affinity to CK2 was performed by fluorophore-conjugated CK2 and subsequent flow cytometry...
January 5, 2017: Pharmaceuticals
Guang-Chun Cheng, Guang-Lan Li, Cai-Di Liu, Li-Fang Yuan, Wen-Wen Chen, Ce Hao
Promoting the oxygen reduction reaction (ORR) catalytic activities of cost-effective catalysts is significant for the development of various energy conversion and storage systems. Herein, a highly active N and S co-doped ketjenblack (Kb) was prepared by facile pyrolyzing the mixture of thiourea and Kb in the presence of FeCl3 with a subsequently acid-leaching process. This novel synthetic approach was rational designed with the virtues that the thiourea could easily introduce the heteroatoms of both N and S elements into the carbon matrix by releasing plentiful reactive N and S-containing gases, and could simultaneously optimize the porous structure of the resultant catalyst...
January 8, 2017: Chemistry: a European Journal
Jee Won Lee, Dohwan Lee, Yong Tae Kim, Eun Yeol Lee, Do Hyun Kim, Tae Seok Seo
This paper describes the development of a novel paper-based capillary electrophoresis (pCE) microdevice using mineral paper, which is durable, oil and tear resistant, and waterproof. The pCE device is inexpensive (~$1.6 per device for materials), simple to fabricate, lightweight, and disposable, so it is more adequate for point-of-care (POC) pathogen diagnostics than a conventional CE device made of glass, quartz, silicon or polymer. In addition, the entire fabrication process can be completed within 1h without using expensive clean room facilities and cumbersome photolithography procedures...
December 28, 2016: Biosensors & Bioelectronics
W Choi, M Xue, B Lane, M Kang, K Patel, W Regine, P Klahr, J Wang, S Chen, W D'souza, W Lu
PURPOSE: To develop an individually optimized contrast-enhanced (CE) 4D-CT for radiotherapy simulation in pancreatic ductal adenocarcinomas (PDA). METHODS: Ten PDA patients were enrolled. Each underwent 3 CT scans: a 4D-CT immediately following a CE 3D-CT and an individually optimized CE 4D-CT using test injection. Three physicians contoured the tumor and pancreatic tissues. We compared image quality scores, tumor volume, motion, tumor-to-pancreas contrast, and contrast-to-noise ratio (CNR) in the 3 CTs...
June 2016: Medical Physics
Y Zlateva, J Seuntjens, I El Naqa
PURPOSE: We propose a Cherenkov emission (CE)-based reference dosimetry method, which in contrast to ionization chamber-based dosimetry, employs spectrum-averaged electron restricted mass collision stopping power-to-Cherenkov power ratios (SCRs), and we examine Monte Carlo-calculated SCRs and beam quality specification of clinical electron beams. METHODS: The EGSnrc user code SPRRZnrc was modified to compute SCRs instead of stopping-power ratios (single medium: water; cut-off: CE threshold (observing Spencer-Attix conditions); CE power: Frank-Tamm)...
June 2016: Medical Physics
Lucas E Sweet, Jordan F Corbey, Frédéric Gendron, Jochen Autschbach, Bruce K McNamara, Kate L Ziegelgruber, Leah M Arrigo, Shane M Peper, Jon M Schwantes
Herein, we report the synthesis and structural characterization of K8[(CO3)3Pu]2(μ-η(2)-η(2)-O2)2·12H2O. This is the second Pu-containing addition to the previously studied alkali-metal peroxocarbonate series M8[(CO3)3A]2(μ-η(2)-η(2)-O2)2·xH2O (M = alkali metal; A = Ce or Pu; x = 8, 10, 12, or 18), for which only the M = Na analogue has been previously reported when A = Pu. The previously reported crystal structure for Na8[(CO3)3Pu]2(μ-η(2)-η(2)-O2)2·12H2O is not isomorphous with its known Ce analogue...
December 29, 2016: Inorganic Chemistry
Yoshiharu Ohno, Yasuko Fujisawa, Hisanobu Koyama, Yuji Kishida, Shinichiro Seki, Naoki Sugihara, Takeshi Yoshikawa
PURPOSE: To directly compare the capability of dynamic first-pass contrast-enhanced (CE-) perfusion area-detector CT (ADCT) and PET/CT for early prediction of treatment response, disease progression and overall survival of non-small cell carcinoma (NSCLC) patients treated with chemoradiotherapy. MATERIALS AND METHODS: Fifty-three consecutive Stage IIIB NSCLC patients who had undergone PET/CT, dynamic first-pass CE-perfusion ADCT, chemoradiotherapy, and follow-up examination were enrolled in this study...
January 2017: European Journal of Radiology
Markus Pollnau, Manfred Hammer, Chaitanya Dongre, Hugo J W M Hoekstra
DNA sequencing by microchip capillary electrophoresis (CE) enables cheap, high-speed analysis of low reagent volumes. One of its potential applications is the identification of genomic deletions or insertions associated with genetic illnesses. Detecting single base-pair insertions or deletions from DNA fragments in the diagnostically relevant size range of 150-1000 base-pairs requires a variance of σ(2) < 10(-3). In a microfluidic chip post-processed by femtosecond-laser writing of an optical waveguide we CE-separated 12 blue-labeled and 23 red-labeled DNA fragments in size...
December 1, 2016: Biomedical Optics Express
Harry F Lee, Jie Fei, Christopher Y S Chan, Qing Pei, Xin Jia, Ricci P H Yue
This study seeks to provide further insight regarding the relationship of climate-epidemics in Chinese history through a multi-scalar analysis. Based on 5961 epidemic incidents in China during 1370-1909 CE we applied Ordinary Least Square regression and panel data regression to verify the climate-epidemic nexus over a range of spatial scales (country, macro region, and province). Results show that epidemic outbreaks were negatively correlated with the temperature in historical China at various geographic levels, while a stark reduction in the correlational strength was observed at lower geographic levels...
December 15, 2016: Social Science & Medicine
Hua-Tao Feng, Min Su, Farida Nur Rifai, Pingjing Li, Sam F Y Li
The deep involvement of glycans or carbohydrate moieties in biological processes makes glycan patterns an important direction for the clinical and medicine researches. A multiplexing CE mapping method for glycan analysis was developed in this study. By applying different CE separation mechanisms, the potential of combined parallel applications of capillary zone electrophoresis (CZE), micellar electrokinetic chromatography (MEKC) and capillary gel electrophoresis (CGE) for rapid and accurate identification of glycan was investigated...
February 8, 2017: Analytica Chimica Acta
Fangming Wang, Zeyu Zhou, Wei Liu, Lei Zhou, Lizhuang Chen, Jing Li
Two luminescent metal-organic-frameworks (LMOFs) constructed by a molecular chromophore [tri(4-pyridylphenyl)amine] (tppa) were synthesized by solvothermal reactions and characterized by single crystal and powder X-ray diffraction, thermogravimetric analysis, optical diffuse reflection, photoluminescence spectroscopy, and internal quantum yield measurements. Both compound 1 [Zn(tppa)(ndc)·(DMF)4] and compound 2 [Zn4(tppa)2(sdc)3(NO3)2·(DMF)4·(ACN)2] (ndc = 2,6-naphthalenedicarboxylic acid, sdc = (E)-4,4'-(ethene-1,2-diyl)dibenzoic acid, DMF = dimethylformamide, ACN = acetonitrile) exhibit intense yellow emission under blue light (455 nm) excitation...
December 23, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
Carsten W Lederer, Eleni Pavlou, George A Tanteles, Paola Evangelidou, Carolina Sismani, Annita Kolnagou, Maria Sitarou, Soteroulla Christou, Michael Hadjigavriel, Marina Kleanthous
OBJECTIVES: Thalassaemia is a potentially lethal inherited anaemia, caused by reduced or absent synthesis of globin chains. Measurement of the minor adult haemoglobin Hb A2, combining α- with δ-globin, is critical for the routine diagnosis of carrier status for α- or β-thalassaemia. Here, we aim to characterize a novel δ-globin variant, Hb A2 Episkopi, in a single family of mixed Lebanese and Cypriot ancestry with mild hypochromic anaemia and otherwise normal globin genotype, which also presents with a coincidental 0...
December 22, 2016: Hematology (Amsterdam, Netherlands)
Federico Moretti, Karine Hovhannesyan, Marina Derdzyan, Gregory Bizarri, Edith Bourret, Ashot Petrosyan, Christophe Dujardin
The influence of Ca codoping on the optical absorption, photo-, radio-, and thermo-luminescence properties of YAlO3:Ce (YAP:Ce) crystals has been studied for four different calcium concentrations from 0 to 500 ppm. The luminescence time response under pulsed X-ray excitation of the Ce3+/Ce4+ balance clearly demonstrates the role of hole migration on both the rise time and the generally observed slow components. From an application point of view, Ca-codoping significantly improves the timing performances but the induced presence of Ce4+ ions is also the cause of a reduction in scintillation efficiency...
December 22, 2016: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
Jeong-Whan Son, Min Sun Lee, Jae Sung Lee
Positron emission tomography (PET) detectors with the ability to encode depth-of-interaction (DOI) information allow us to simultaneously improve the spatial resolution and sensitivity of PET scanners. In this study, we propose a DOI PET detector based on a stair-pattern reflector arrangement inserted between pixelated crystals and a single-ended scintillation light readout. The main advantage of the proposed method is its simplicity; DOI information is decoded from a flood map and the data can be simply acquired by using a single-ended readout system...
December 21, 2016: Physics in Medicine and Biology
Kunal Mukherjee, Yoshiaki Hayamizu, Chang Sub Kim, Liudmila M Kolchina, Galina N Mazo, Sergey Ya Istomin, Sean R Bishop, Harry L Tuller
Highly textured thin films of undoped, Ce-doped, and Sr-doped Pr2CuO4 were synthesized on single crystal YSZ substrates using pulsed laser deposition to investigate their area-specific resistance (ASR) as cathodes in solid-oxide fuel cells (SOFCs). The effects of T' and T* crystal structures, donor and acceptor doping, and a-axis and c-axis orientation on ASR were systematically studied using electrochemical impedance spectroscopy on half cells. The addition of both Ce and Sr dopants resulted in improvements in ASR in c-axis oriented films, as did the T* crystal structure with the a-axis orientation...
December 21, 2016: ACS Applied Materials & Interfaces
Mengqiao Li, Jilin Zhang, Jin Han, Zhongxian Qiu, Wenli Zhou, Liping Yu, Zhiqiang Li, Shixun Lian
A series of color-tunable Ce(3+) single-doped and Ce(3+), Mn(2+) codoped Ca2.5Sr0.5Al2O6 phosphors were synthesized by a high-temperature solid-state reaction. The crystal structure, luminescent properties, and energy transfer were studied. For Ca2.5Sr0.5Al2O6:Ce(3+) phosphors obtained with Al(OH)3 as the raw material, three emission profiles were observed. The peak of photoluminescence (PL) spectra excited at ∼360 nm shifts from 470 to 420 nm, while that of the PL spectra excited at 305 nm stays unchanged at 470 nm with the increase of Ce(3+) content...
January 3, 2017: Inorganic Chemistry
Daniel A Friedlander, Heather N Di Carlo, Paul D Sponseller, John P Gearhart
BACKGROUND/PURPOSE: The aims of surgical management in cloacal exstrophy (CE) have shifted to optimizing outcomes and quality of life while minimizing morbidity. This report reviews the single-institution experience of complications of bladder closure in CE. METHODS: Patients with CE were identified from a prospectively-maintained bladder exstrophy-epispadias complex database. Operative and follow-up data were analyzed to compare complications and failure rates of bladder closure between closures performed with and without osteotomy and primary versus reoperative closures...
December 9, 2016: Journal of Pediatric Surgery
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