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Dan Zou, Xujun Chu, Wenhao Lu, Jiayi Yan, Mingkang Ye, Shuiyi Hu, Fenju Qin
OBJECTIVE: To study the effects of cerium oxide nanoparticles( CeO_2 NPs)on cognitive function in 48 hours of sleep deprived male mice and explore its mechanism. METHODS: Thirty-six healthy clean ICR male mice( four weeks old) were randomly divided into 6 groups: blank control group, solvent control group, sleep deprivation control group, low, medium and high dose groups of CeO_2 NPs. 1 m L of distilled water were given to mice of blank group, 1 m L of solvent were given to mice of solvent control and sleep deprivation control group, 1 mL of CeO_2 NPs solvent( 4, 8, 16 mg/kg) were administered to mice of low, medium and high dose groups of CeO_2 NPs...
January 2018: Wei Sheng Yan Jiu, Journal of Hygiene Research
Kai-Ti Chu, Yu-Chiao Liu, Min-Wen Chung, Agus Riyanto Poerwoprajitno, Gene-Hsiang Lee, Ming-Hsi Chiang
The intrinsic catalytic property of a Fe-S complex toward H2 evolution was investigated in a wide range of acids. The title complex exhibited catalytic events at -1.16 and -1.57 V (vs Fc+ /Fc) in the presence of trifluoromethanesulfonic acid (HOTf) and trifluoroacetic acid (TFA), respectively. The processes corresponded to the single reduction of the Fe-hydride-S-proton and Fe-hydride species, respectively. When anilinium acid was used, the catalysis occurred at -1.16 V, identical with the working potential of the HOTf catalysis, although the employment of anilinium acid was only capable of achieving the Fe-hydride state on the basis of the spectral and calculated results...
June 12, 2018: Inorganic Chemistry
Álvaro Roy, José Antonio Infantes-Lorenzo, Juan Carlos Blázquez, Ángel Venteo, Francisco José Mayoral, Mercedes Domínguez, Inmaculada Moreno, Beatriz Romero, Lucía de Juan, Anna Grau, Lucas Domínguez, Javier Bezos
Vaccination against paratuberculosis (PTB) in goats is a cost-effective control strategy, and is also effective as regards preventing the onset of clinical cases. However, it causes interference in the diagnostic tests used in the control of tuberculosis (TB). A group of 99 goats from a herd with no history of TB or PTB infection was vaccinated against PTB at seven months of age. They then underwent consecutive intradermal tests [single (SIT) and comparative (CIT) intradermal tuberculin tests), interferon-gamma release assays (IGRA) and two serological tests (p22_CE and DR-ELISA) every three months, until the interference disappeared...
August 1, 2018: Preventive Veterinary Medicine
Ha Yeon Kim, Sook Young Lee, Seyoon Kang, Bora Kim, Yeo Rae Moon, Ji Eun Kim
Background: Remifentanil infusion during emergence lowers cough. Effect-site concentration (Ce) of remifentanil using target-controlled infusion (TCI) has been evaluated in previous studies. Recent studies revealed the existence of sex-related differences in remifentanil Ce in young and elderly patients. Thus, there was the need to re-evaluate the effect of age in single sex. We investigated the remifentanil Ce for suppressing emergence cough in young and elderly male patients and evaluated the age-related differences...
2018: Clinical Interventions in Aging
Li Cheng, Chengxi Liu, Shuang-Ying Jiang, Sha Hou, Jin-Guo Huang, Zi-Qing Chen, Yangyang Sun, Huan Qi, He-Wei Jiang, Jingfang Wang, Yi-Ming Zhou, Daniel M Czajkowsky, Jun-Biao Dai, Sheng-Ce Tao
Proteins, as the major executer for cell progresses and functions, its abundance and the level of post-translational modifications, are tightly monitored by regulators. Genetic perturbation could help us to understand the relationships between genes and protein functions. Herein, to explore the impact of the genome-wide interruption on certain protein, we developed a cell lysate microarray on kilo-conditions (CLICK) with 4,837 knockout (YKO) and 322 temperature-sensitive (ts) mutant strains of yeast (Saccharomyces cerevisiae)...
June 5, 2018: Molecular & Cellular Proteomics: MCP
Rose-Marie Galera, Christine Opagiste, Mehdi Amara, Jean-Christophe Toussaint, Marie-Bernadette Lepetit, Stephane Rols
We present here a quantitative analysis of the ground state and magnetic properties of Ce3Pt23Si11, based on a crystalline electric field description within the mean-field approximation. In this face-centered cubic compound, the point group symmetry at the Ce site is orthorhombic. One main difficulty in this low symmetry case is that the CEF potential for Ce3+ ions is determined by five independent parameters, while only two magnetic excitations are observed by inelastic neutron scattering. Moreover the anisotropy of the magnetic susceptibility of the Ce ion, that permits an independent determination of the second-order CEF parameters is hidden by the cubic symmetry of the compound...
June 5, 2018: Journal of Physics. Condensed Matter: An Institute of Physics Journal
Xintao Hu, Antonio Valentin, Yanhui Cai, Frances Dayton, Margherita Rosati, Eric G Ramirez-Salazar, Viraj Kulkarni, Kate Elizabeth Broderick, Niranjan Y Sardesai, Linda S Wyatt, Patricia L Earl, Bernard Moss, James I Mullins, George N Pavlakis, Barbara K Felber
We developed DNA-based vaccines able to induce efficient cytotoxic T cell responses targeting conserved elements (CE) of HIV-1 Gag. These CE were selected by stringent conservation, the ability to induce T cell responses with broad HLA coverage and the association between recognition of CE epitopes and viral control in HIV-infected individuals. Based on homology to HIV, we also developed an SIV p27gag CE DNA vaccine. In this study, we report on the durability of the CE-specific T cell responses induced by HIV and SIV CE DNA-based prime/boost vaccine regimens in rhesus macaques and show that the initially primed CE-specific T cell responses were efficiently boosted by a single CE DNA vaccination after the long rest period (up to two years)...
June 5, 2018: Human Gene Therapy
Michael Perkuhn, Pantelis Stavrinou, Frank Thiele, Georgy Shakirin, Manoj Mohan, Dionysios Garmpis, Christoph Kabbasch, Jan Borggrefe
OBJECTIVES: The aims of this study were, first, to evaluate a deep learning-based, automatic glioblastoma (GB) tumor segmentation algorithm on clinical routine data from multiple centers and compare the results to a ground truth, manual expert segmentation, and second, to evaluate the quality of the segmentation results across heterogeneous acquisition protocols of routinely acquired clinical magnetic resonance imaging (MRI) examinations from multiple centers. MATERIALS AND METHODS: The data consisted of preoperative MRI scans (T1, T2, FLAIR, and contrast-enhanced [CE] T1) of 64 patients with an initial diagnosis of primary GB, which were acquired in 15 institutions with varying protocols...
May 31, 2018: Investigative Radiology
Richard Trevino, William E Sponsel, Carolyn E Majcher, Joey Allen, Jeffery Rabin
Aim: To determine the association of Diopsys® NOVA-LX amplitude and latency abnormality scores with perimetric staging of chronic glaucoma, and to explore potential single-visit short-duration transient visual evoked potential (SD-tVEP) trend detection ability utilizing Humphrey 30-2 field progression data. Materials and methods: Setting: Glaucoma subspecialty clinic. Participants: Treated adult chronic glaucoma patients undergoing SD-tVEP evaluation. Main outcome measures: (1) Proportion of eyes designated as suspect or abnormal by the NOVA-LX multifactorial algorithm were determined as a function of glaucoma severity using the most recent Humphrey visual field analyzer (HVFA) 30-2 field...
January 2018: Journal of Current Glaucoma Practice
Pei-Qiang Ma, Cheng-Pin Liang, He-Hua Zhang, Bin-Cheng Yin, Bang-Ce Ye
Synthetic molecular machines have received increasing attention because of their great ability to mimic natural biological motors and create novel modes of motion. However, very few examples have been implemented with real autonomous movement inside living cells, due to the challenges of the driving force and highly integrated system design. In this work, we report an elegant, highly integrated DNA nanomachine that can be powered by endogenous ATP molecules and autonomously operated inside living cells without any auxiliary additives...
April 7, 2018: Chemical Science
Ralf Janssen, Linushiya Lionel
Recent research has shown that Toll genes, and in particular a newly defined class of Toll genes, the so-called Long Toll Genes (Loto genes), are crucial factors in embryogenesis. In arthropods, they are involved in axis formation via a process called convergent extension (CE). A hallmark of Loto genes is their relatively (compared to other Toll genes) high number of leucine-rich repeat elements (LRRs) coupled with the fact that they are expressed in transverse stripes in all segments, or a subset of segments, patterns that are reminiscent of classical segmentation genes such as the pair-rule genes...
May 26, 2018: Development Genes and Evolution
C Hussing, R Bytyci, C Huber, N Morling, C Børsting
Some STR loci have internal sequence variations, which are not revealed by the standard STR typing methods used in forensic genetics (PCR and fragment length analysis by capillary electrophoresis (CE)). Typing of STRs with next-generation sequencing (NGS) uncovers the sequence variation in the repeat region and in the flanking regions. In this study, 363 Danish individuals were typed for 56 STRs (26 autosomal STRs, 24 Y-STRs, and 6 X-STRs) using the ForenSeq™ DNA Signature Prep Kit to establish a Danish STR sequence database...
May 24, 2018: International Journal of Legal Medicine
L C Adams, B Ralla, G Engel, G Diederichs, B Hamm, J Busch, F Fuller, M R Makowski
AIM: To test the potential of unenhanced cardiac- and respiratory-motion-corrected three-dimensional steady-state free precession (3D-SSFP) magnetic resonance imaging (MRI) for the assessment of inferior vena cava (IVC) thrombus in patients with clear-cell renal cell carcinoma (cRCC), compared to standard contrast-enhanced (CE)-MRI and CE-computed tomography (CT). MATERIALS AND METHODS: Eighteen patients with cRCC and IVC thrombus, who received CE-MRI and 3D-SSFP at 1...
May 17, 2018: Clinical Radiology
Diego Forni, Rachele Cagliani, Chiara Pontremoli, Uberto Pozzoli, Jacopo Vertemara, Luca De Gioia, Mario Clerici, Manuela Sironi
Hepatitis C virus (HCV) belongs to the Hepacivirus genus and is genetically heterogeneous, with seven major genotypes further divided into several recognized subtypes. HCV origin was previously dated in a range between ∼200 and 1000 years ago. Hepaciviruses have been identified in several domestic and wild mammals, the largest viral diversity being observed in bats and rodents. The closest relatives of HCV were found in horses/donkeys (equine hepaciviruses, EHV). However, the origin of HCV as a human pathogen is still an unsolved puzzle...
2018: Frontiers in Microbiology
Joshua W Cates, Craig S Levin
Commercially available clinical positron emission tomography (PET) detectors employ scintillation crystals that are long (20 mm length) and narrow (4-5 mm width) optically coupled on their narrow end to a photosensor. The aspect ratio of this traditional crystal rod conguration and 511 keV photon attenuation properties yield signicant variances in scintillation light collection efficiency and transit time to the photodetector, due to variations in the 511 keV photon interaction depth in the crystal. These variances contribute significantly to coincidence time resolution degradation...
May 15, 2018: Physics in Medicine and Biology
Qian Zhang, Chenguang Liu, Shuhui Tao, Ruowei Yi, Weitao Su, Ce Zhou Zhao, Chun Zhao, Yannick J Dappe, Richard J Nichols, Li Yang
In this study, we introduce an efficient data sorting algorithm, including filters for noisy signals, conductance mapping for analyzing the most dominant conductance group and sub-population groups. The capacity of our data analysis process has also been corroborated on real experimental data sets. Over 11,000 I(s) traces, representing the current (I) versus STM tip retraction distance (s) signals of Au-1,6-hexanedithiol-Au and Au-1,8-octanedithiol-Au molecular junctions have been collected. The fully automated and unsupervised program requires less than one minute on a standard PC to achieve sort the data and generate histograms...
May 14, 2018: Nanotechnology
Jiping Yang, Bei Yang, Baoxin Xiu, Jinchong Qi, Huaijun Liu
Because most tested drugs are active against only one of the damaging processes associated with stroke, other mechanisms may cause cellular death. Thus, a combination of protective agents targeting different pathophysiological mechanisms may obtain better effects than a single agent. The major objective of this study was to investigate the effect of combination therapy with vascular endothelial growth factor (VEGF) and nerve growth factor (NGF) after controlled ischemic brain injury in rabbits. METHODS: Animals were randomly assigned to one of the following groups: sham group, saline-treated control group or NGF+VEGF-treated group...
May 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
Orkhontuul Shirmen, Batbold Batchuluun, Avaajigmed Lkhamjav, Tugbayar Tseveen, Tsetsegdelger Munkhjargal, Tsogtsaikhan Sandag, Enkhsaikhan Lkhagvasuren, Tetsuya Yanagida, Yuji Nishikawa, Akira Ito
Recent molecular re-evaluation of Echinococcus granulosus, which causes cystic echinococcosis (CE), has revealed that it is not a single species, but instead consists of 5 cryptic species. Among them, E. granulosus (dog-sheep strain) is predominant (75%) followed by Echinococcus canadensis (22%). The major affected organs, in humans, are the liver (88%) and lungs (11%). Primary cerebral CE comprises less than 1% of all cases. As cerebral CE cases are rare, there are few reports with molecular confirmation of the causative species...
May 9, 2018: Parasitology International
Balázs Dezsényi, Áron Somorácz, József Danka, István Kucsera, Thomas F E Barth, Adriano Casulli
PURPOSE: Cystic echinococcosis (CE) is a parasitic disease caused by the tapeworm Echinococcus granulosus sensu lato. Although in Hungary the disease is listed among reportable infections, inadequacies in the reporting practice of CE by clinicians and pathologists have resulted in underscoring of this disease. The aim of this study was to describe the epidemiological and clinical characteristics of CE in Hungary using a datasource other than the official records that are based mainly on serological data...
May 11, 2018: Infection
Nicholas A McKeag, Rebecca L Noad, Kyle Ashfield, Carol M Wilson, David J McEneaney, Michael J D Roberts
INTRODUCTION: Insulation failure leading to conductor externalization (CE) of a Linox (Biotronik, Berlin, Germany) implantable cardioverter defibrillator (ICD) lead has recently been reported. The aim of this study was to assess prospectively all Linox family ICD leads implanted at our center for evidence of CE or an electrical abnormality. METHODS: All patients with a Linox family ICD lead implanted at our center, between November 2007 and March 2015, were identified and all living patients were invited to attend for fluoroscopic screening and electrical assessment of the lead...
May 5, 2018: Advances in Therapy
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