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https://www.readbyqxmd.com/read/27890680/the-putative-role-of-maldi-msi-in-the-study-of-membranous-nephropathy
#1
Andrew Smith, Vincenzo L'Imperio, Elena Ajello, Franco Ferrario, Niccolò Mosele, Martina Stella, Manuel Galli, Clizia Chinello, Federico Pieruzzi, Goce Spasovski, Fabio Pagni, Fulvio Magni
Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents the leading cause of nephrotic syndrome in adults and is one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate management of patients. In secondary cases, the best strategy consists in treating the underlying disease whereas in primary forms, the possible identification of confirmatory markers of the idiopathic etiology underlining the process is requested by clinicians...
November 23, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27876003/pla2r-antibodies-and-pla2r-glomerular-deposits-in-psoriasis-patients-with-membranous-nephropathy
#2
Yong-Chun Ge, Bo Jin, Cai-Hong Zeng, Ming-Chao Zhang, Da-Cheng Chen, Ru Yin, Wei-Bo Le
BACKGROUND: The association between psoriasis and membranous nephropathy (MN) remains largely unclear. We examined the prevalence of serum PLA2R antibody and characterized the expression of PLA2R and THSD7A in glomeruli in patients with MN and psoriasis. METHODS: A total of 24 patients with MN without evidence of a secondary cause except psoriasis were enrolled. The clinical and pathological features were retrospectively analyzed. Serum anti-PLA2R antibody was measured using IFA Mosaic...
November 22, 2016: BMC Nephrology
https://www.readbyqxmd.com/read/27777266/a-proposal-for-a-serology-based-approach-to-membranous-nephropathy
#3
An S De Vriese, Richard J Glassock, Karl A Nath, Sanjeev Sethi, Fernando C Fervenza
Primary membranous nephropathy (MN) is an autoimmune disease mainly caused by autoantibodies against the recently discovered podocyte antigens: the M-type phospholipase A2 receptor 1 (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A). Assays for quantitative assessment of anti-PLA2R antibodies are commercially available, but a semiquantitative test to detect anti-THSD7A antibodies has been only recently developed. The presence or absence of anti-PLA2R and anti-THSD7A antibodies adds important information to clinical and immunopathologic data in discriminating between primary and secondary MN...
October 24, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27634909/biomarkers-to-detect-membranous-nephropathy-in-chinese-patients
#4
Li Lin, Wei Ming Wang, Xiao Xia Pan, Jing Xu, Chen Ni Gao, Wen Zhang, Hong Ren, Jing Yuan Xie, Pin Yan Shen, Yao Wen Xu, Li Yan Ni, Nan Chen
Anti-M-type phospholipase A2 receptor (anti-PLA2R) is a widely accepted biomarker for clinical idiopathic membranous neurophathy (IMN). However, its ability to differentiate between IMN and secondary MN (SMN) is controversial. The objective of this study was to assess clinical MN biomarkers in blood, tissue and urine samples from Chinese patients. In total, 195 MN patients and 70 patients with other glomerular diseases were prospectively enrolled in the study. Participants were followed up for average of 17 months (range 3-39 months)...
September 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27629964/membranous-nephropathy-with-an-enhanced-granular-expression-of-thrombospondin-type-1-domain-containing-7a-in-a-pregnant-woman
#5
Takamasa Iwakura, Yoshihide Fujigaki, Naoko Katahashi, Taichi Sato, Sayaka Ishigaki, Naoko Tsuji, Yoshitaka Naito, Shinsuke Isobe, Masashi Ono, Yukitoshi Sakao, Takayuki Tsuji, Naro Ohashi, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda
A 30-year-old woman with proteinuria first noted at 26 weeks of gestation was admitted to undergo further evaluation. A renal biopsy revealed membranous nephropathy (MN). There was no evidence of any secondary MN. Prednisolone was initiated 6 months after delivery. Four months later, her urine protein became negative. Enhanced granular staining for thrombospondin type-1 domain-containing 7A (THSD7A) in the glomeruli was retrospectively detected in a biopsy specimen. A literature review revealed that 60% of cases of THSD7A-related MN occurred in women of childbearing age...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27536672/management-of-membranous-nephropathy-in-asia
#6
REVIEW
Jing Xu, Xiaofan Hu, Jingyuan Xie, Nan Chen
BACKGROUND: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults, accounting for about 20.0% of all NS cases. With an increasing prevalence, especially in the elderly, it has received great attention in Asia. SUMMARY: Recently, the prevalence of idiopathic MN (IMN) has significantly increased among the elderly people in Asia and other places in the world. Although the exact mechanism of IMN remains unveiled, the identification of new antigens such as PLA2R and THSD7A has greatly enhanced our understanding of its pathogenesis...
September 2015: Kidney Diseases
https://www.readbyqxmd.com/read/27484901/motor-neuron-derived-thsd7a-is-essential-for-zebrafish-vascular-development-via-the-notch-dll4-signaling-pathway
#7
Lawrence Yu-Min Liu, Min-Hsuan Lin, Zih-Yin Lai, Jie-Peng Jiang, Yi-Ching Huang, Li-En Jao, Yung-Jen Chuang
BACKGROUND: Development of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions. Previously, our group identified a highly conserved neural protein called thrombospondin type I domain containing 7A (THSD7A). Soluble THSD7A promoted and guided endothelial cell migration, tube formation and sprouting. In addition, we showed that thsd7a could be detected in the nervous system and was required for intersegmental vessels (ISV) patterning during zebrafish development...
2016: Journal of Biomedical Science
https://www.readbyqxmd.com/read/27436855/an-indirect-immunofluorescence-method-facilitates-detection-of-thrombospondin-type-1-domain-containing-7a-specific-antibodies-in-membranous-nephropathy
#8
Elion Hoxha, Laurence H Beck, Thorsten Wiech, Nicola M Tomas, Christian Probst, Swantje Mindorf, Catherine Meyer-Schwesinger, Gunther Zahner, Phillip R Stahl, Ruth Schöpper, Ulf Panzer, Sigrid Harendza, Udo Helmchen, David J Salant, Rolf A K Stahl
Thrombospondin type 1 domain-containing 7A (THSD7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major antigen phospholipase A2 receptor 1 (PLA2R1). The prevalence of THSD7A-Ab-positive patients is unknown, and it is unclear whether the clinical presentation differs between patients positive for PLA2R1-Ab or THSD7A-Ab. We screened serum samples of 1276 patients with MN from three different cohorts for the presence of THSD7A-Ab by Western blot analysis and a newly developed indirect immunofluorescence test (IFT)...
July 19, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27214550/autoantibodies-against-thrombospondin-type-1-domain-containing-7a-induce-membranous-nephropathy
#9
Nicola M Tomas, Elion Hoxha, Anna T Reinicke, Lars Fester, Udo Helmchen, Jens Gerth, Friederike Bachmann, Klemens Budde, Friedrich Koch-Nolte, Gunther Zahner, Gabriele Rune, Gerard Lambeau, Catherine Meyer-Schwesinger, Rolf A K Stahl
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, and one-third of patients develop end-stage renal disease (ESRD). Circulating autoantibodies against the podocyte surface antigens phospholipase A2 receptor 1 (PLA2R1) and the recently identified thrombospondin type 1 domain-containing 7A (THSD7A) are assumed to cause the disease in the majority of patients. The pathogenicity of these antibodies, however, has not been directly proven. Here, we have reported the analysis and characterization of a male patient with THSD7A-associated MN who progressed to ESRD and subsequently underwent renal transplantation...
July 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27192690/a-mechanism-for-cancer-associated-membranous-nephropathy
#10
LETTER
Elion Hoxha, Thorsten Wiech, Phillip R Stahl, Gunther Zahner, Nicola M Tomas, Catherine Meyer-Schwesinger, Ulrich Wenzel, Matthias Janneck, Oliver M Steinmetz, Ulf Panzer, Sigrid Harendza, Rolf A K Stahl
No abstract text is available yet for this article.
May 19, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27085376/membranous-nephropathy-a-journey-from-bench-to-bedside
#11
REVIEW
Jean M Francis, Laurence H Beck, David J Salant
Lessons from an animal model that faithfully resembles human membranous nephropathy (MN) have informed our understanding of the pathogenesis of this organ-specific autoimmune disease and common cause of nephrotic syndrome. After it was established that the subepithelial immune deposits that characterize experimental MN form in situ when circulating antibodies bind to an intrinsic podocyte antigen, it was merely a matter of time before the human antigen was identified. The M-type phospholipase A2 receptor 1 (PLA2R) represents the major target antigen in primary MN, and thrombospondin type 1 domain-containing 7A (THSD7A) was more recently identified as a minor antigen...
July 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/26902699/lack-of-replication-of-association-of-thsd7a-with-obesity
#12
LETTER
M Ahmad, S S Nongmaithem, G V Krishnaveni, C H D Fall, C S Yajnik, G R Chandak
No abstract text is available yet for this article.
April 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26902698/reply-to-lack-of-replication-of-association-of-thsd7a-with-obesity
#13
LETTER
S Nizamuddin, P Govindaraj, S Saxena, M Kashyap, A Mishra, S Singh, H Rotti, R Raval, J Nayak, B K Bhat, B V Prasanna, V R Dhumal, S Bhale, K S Joshi, A P Dedge, R Bharadwaj, G G Gangadharan, S Nair, P M Gopinath, B Patwardhan, P Kondaiah, K Satyamoorthy, M S Valiathan, K Thangaraj
No abstract text is available yet for this article.
April 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26847174/thsd7a-staining-of-membranous-glomerulopathy-in-clinical-practice-reveals-cases-with-dual-autoantibody-positivity
#14
Christopher P Larsen, L Nicholas Cossey, Laurence H Beck
Thrombospondin type I domain-containing 7A (THSD7A) is a known antigenic target of autoantibodies leading to primary membranous glomerulopathy and was reported to account for ~10% of phospholipase A2 receptor (PLA2R)-negative membranous glomerulopathy. It has been proposed that PLA2R and THSD7A autoantibodies are mutually exclusive in membranous glomerulopathy. We validated an immunohistochemical assay to investigate for THSD7A-associated membranous glomerulopathy and utilized it in 258 consecutive native kidney biopsies, which showed membranous glomerulopathy in our laboratory, with the exception of membranous lupus nephritis...
April 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/26796133/hypoxia-inducible-mir-210-contributes-to-preeclampsia-via-targeting-thrombospondin-type-i-domain-containing-7a
#15
Rongcan Luo, Yongqing Wang, Peng Xu, Guangming Cao, Yangyu Zhao, Xuan Shao, Yu-xia Li, Cheng Chang, Chun Peng, Yan-ling Wang
Preeclampsia, a relatively common pregnancy disorder, is a major contributor to maternal mortality and morbidity worldwide. An elevation in microRNA-210 (miR-210) expression in the placenta has been reported to be associated with preeclampsia. Our bioinformatic analysis showed that thrombospondin type I domain containing 7A (THSD7A) is a predicted target for miR-210. The aim of this study was to determine whether miR-210 is involved in preeclampsia through its targeting of THSD7A in human placental trophoblasts...
2016: Scientific Reports
https://www.readbyqxmd.com/read/26238973/a-novel-gene-thsd7a-is-associated-with-obesity
#16
S Nizamuddin, P Govindaraj, S Saxena, M Kashyap, A Mishra, S Singh, H Rotti, R Raval, J Nayak, B K Bhat, B V Prasanna, V R Dhumal, S Bhale, K S Joshi, A P Dedge, R Bharadwaj, G G Gangadharan, S Nair, P M Gopinath, B Patwardhan, P Kondaiah, K Satyamoorthy, M S Valiathan, K Thangaraj
Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent...
November 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/26142398/spontaneous-remission-of-proteinuria-is-a-frequent-event-in-phospholipase-a2-receptor-antibody-negative-patients-with-membranous-nephropathy
#17
Elion Hoxha, Sigrid Harendza, Hans O Pinnschmidt, Nicola M Tomas, Udo Helmchen, Ulf Panzer, Rolf A K Stahl
BACKGROUND: Phospholipase A2 receptor antibodies (PLA2R-Ab) and thrombospondin type-1 domain-containing 7A antibodies (THSD7A-Ab) are present in 70-80% of patients with membranous nephropathy (MN). Little, however, is known about the pathogenesis of MN and the clinical outcome in PLA2R-Ab- and THSD7A-Ab-negative patients. METHODS: In this prospective multicentre observational study, the clinical outcome of 37 patients with biopsy-proven MN who were negative for PLA2R-Ab and THSD7A-Ab in the serum was analysed...
November 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25808521/y-craniosynostosis-by-premature-fusion-of-the-metopic-and-coronal-sutures-a-new-nosological-entity-or-a-variety-of-saethre-chotzen-syndrome
#18
Federico di Rocco, Alexandra Benoit, Jacqueline Vigneron, Pascale Bach Segura, Olivier Klein, Corinne Collet, Eric Arnaud
BACKGROUND: New forms and varieties of craniosynostoses are continuously identified due to the current increased interest of clinicians and genetists especially since the introduction of microarray-based comparative genomic hybridization (Array-CGH) techniques in the diagnostic setting of patients with craniofacial anomalies. METHODS: In this report, we describe the case of an infant who associated the early fusion of the metopic and both the coronal sutures. The interaction of the early fusion of the anterior group of the main cranial sutures gave the infant a particular clinical phenotypes with a Y configuration of the frontal bone and a globally reduced size of the skull...
April 2015: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/25394321/thrombospondin-type-1-domain-containing-7a-in-idiopathic-membranous-nephropathy
#19
Nicola M Tomas, Laurence H Beck, Catherine Meyer-Schwesinger, Barbara Seitz-Polski, Hong Ma, Gunther Zahner, Guillaume Dolla, Elion Hoxha, Udo Helmchen, Anne-Sophie Dabert-Gay, Delphine Debayle, Michael Merchant, Jon Klein, David J Salant, Rolf A K Stahl, Gérard Lambeau
BACKGROUND: Idiopathic membranous nephropathy is an autoimmune disease. In approximately 70% of patients, it is associated with autoantibodies against the phospholipase A2 receptor 1 (PLA2R1). Antigenic targets in the remaining patients are unknown. METHODS: Using Western blotting, we screened serum samples from patients with idiopathic membranous nephropathy, patients with other glomerular diseases, and healthy controls for antibodies against human native glomerular proteins...
December 11, 2014: New England Journal of Medicine
https://www.readbyqxmd.com/read/23742623/genome-wide-linkage-scan-in-affected-sibling-pairs-identifies-novel-susceptibility-region-for-venous-thromboembolism-genetics-in-familial-thrombosis-study
#20
M C H de Visser, R van Minkelen, V van Marion, M den Heijer, J Eikenboom, H L Vos, P E Slagboom, J J Houwing-Duistermaat, F R Rosendaal, R M Bertina
BACKGROUND: Venous thromboembolism (VTE) is a multicausal disorder involving environmental and genetic risk factors. In many thrombophilic families the clustering of thrombotic events cannot be explained by known genetic risk factors, indicating that some remain to be discovered. OBJECTIVES: We aimed to identify novel thrombosis susceptibility alleles in a large panel of small thrombophilic families: the Genetics In Familial Thrombosis (GIFT) study. PATIENTS/METHODS: In the GIFT study, 201 families were recruited consisting of 438 siblings with an objectively confirmed VTE at a young age...
August 2013: Journal of Thrombosis and Haemostasis: JTH
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