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Zhichao Hou, Abulajiang Abudureheman, Lei Wang, Ayshamgul Hasim, Julaiti Ainiwaer, Haiping Zhang, Madiniyat Niyaz, Halmurat Upur, Ilyar Sheyhidin
Thsd7a (Thrombospondin type 1 domain containing 7a) is a critical transmembrane protein. Studies have indicated that Thsd7a was associated with cytoskeletal organization, cell migration and filopodia formation. However, the involvement of Thsd7a remains elusive in human Esophageal Squamous Cell Carcinoma (ESCC). Consequently, immunohistochemistry and reverse transcription-polymerase chain reaction were utilized to study the correlation between the expression of Thsd7a and clinical-pathological characteristics...
April 8, 2017: Oncotarget
Franck Pourcine, Karine Dahan, Fabrice Mihout, Marine Cachanado, Isabelle Brocheriou, Hanna Debiec, Pierre Ronco
INTRODUCTION: Clinical course of membranous nephropathy (MN) is difficult to predict. Measurement of circulating anti-PLA2R autoantibodies (PLA2R-Ab) and detection in immune deposits of PLA2R antigen (PLA2R-Ag) are major advances in disease understanding. We evaluated the clinical significance of these biomarkers. METHODS: In this 14-year retrospective study, we collected data from 108 MN patients and assessed the relationship between clinical course, PLA2R-Ab and PLA2R-Ag...
2017: PloS One
Daniel C Cattran, Paul E Brenchley
Idiopathic membranous nephropathy (INM) remains a common cause of the nephrotic syndrome in adults. The autoimmune nature of IMN was clearly delineated in 2009 with the identification of the glomerular-deposited IgG to be a podocyte receptor, phospholipase A2 receptor (PLA2R) in 70% to 75% of cases. This anti-PLA2R autoantibody, predominantly the IgG4 subclass, has been quantitated in serum using an enzyme-linked immunosorbent assay and has been used to aid diagnosis and monitor response to immunosuppressive therapy...
March 2017: Kidney International
Phillip R Stahl, Elion Hoxha, Thorsten Wiech, Cornelia Schröder, Ronald Simon, Rolf A K Stahl
We recently described a case of a Thrombospondin Type-1 Domain containing 7A (THSD7A) associated membranous nephropathy in a female patient who was synchronously suffering from a THSD7A-positive malignancy. We here investigated the role of THSD7A as a new potential tumor antigen by evaluating over 20 000 tissue spots in more than 70 different tumor entities by immunohistochemistry using tissue microarrays. THSD7A expression was highly variable in different neoplasias with differing staining patterns. Both gain and loss of THSD7A expression compared to expression status in non-tumor tissue were linked to tumor-specific markers in the different tumor entities and were of prognostic value...
April 2017: Genes, Chromosomes & Cancer
Andrew Smith, Vincenzo L'Imperio, Elena Ajello, Franco Ferrario, Niccolò Mosele, Martina Stella, Manuel Galli, Clizia Chinello, Federico Pieruzzi, Goce Spasovski, Fabio Pagni, Fulvio Magni
Membranous Nephropathy (MN) is an immunocomplex mediated renal disease that represents one of the most frequent glomerulopathies worldwide. This glomerular disease can manifest as primary (idiopathic) or secondary and this distinction is crucial when choosing the most appropriate course of treatment. In secondary cases, the best strategy involves treating the underlying disease, whereas in primary forms, the identification of confirmatory markers of the idiopathic etiology underlining the process is requested by clinicians...
November 24, 2016: Biochimica et Biophysica Acta
Yong-Chun Ge, Bo Jin, Cai-Hong Zeng, Ming-Chao Zhang, Da-Cheng Chen, Ru Yin, Wei-Bo Le
BACKGROUND: The association between psoriasis and membranous nephropathy (MN) remains largely unclear. We examined the prevalence of serum PLA2R antibody and characterized the expression of PLA2R and THSD7A in glomeruli in patients with MN and psoriasis. METHODS: A total of 24 patients with MN without evidence of a secondary cause except psoriasis were enrolled. The clinical and pathological features were retrospectively analyzed. Serum anti-PLA2R antibody was measured using IFA Mosaic...
November 22, 2016: BMC Nephrology
An S De Vriese, Richard J Glassock, Karl A Nath, Sanjeev Sethi, Fernando C Fervenza
Primary membranous nephropathy (MN) is an autoimmune disease mainly caused by autoantibodies against the recently discovered podocyte antigens: the M-type phospholipase A2 receptor 1 (PLA2R) and thrombospondin type 1 domain-containing 7A (THSD7A). Assays for quantitative assessment of anti-PLA2R antibodies are commercially available, but a semiquantitative test to detect anti-THSD7A antibodies has been only recently developed. The presence or absence of anti-PLA2R and anti-THSD7A antibodies adds important information to clinical and immunopathologic data in discriminating between primary and secondary MN...
February 2017: Journal of the American Society of Nephrology: JASN
Li Lin, Wei Ming Wang, Xiao Xia Pan, Jing Xu, Chen Ni Gao, Wen Zhang, Hong Ren, Jing Yuan Xie, Pin Yan Shen, Yao Wen Xu, Li Yan Ni, Nan Chen
Anti-M-type phospholipase A2 receptor (anti-PLA2R) is a widely accepted biomarker for clinical idiopathic membranous neurophathy (IMN). However, its ability to differentiate between IMN and secondary MN (SMN) is controversial. The objective of this study was to assess clinical MN biomarkers in blood, tissue and urine samples from Chinese patients. In total, 195 MN patients and 70 patients with other glomerular diseases were prospectively enrolled in the study. Participants were followed up for average of 17 months (range 3-39 months)...
October 18, 2016: Oncotarget
Takamasa Iwakura, Yoshihide Fujigaki, Naoko Katahashi, Taichi Sato, Sayaka Ishigaki, Naoko Tsuji, Yoshitaka Naito, Shinsuke Isobe, Masashi Ono, Yukitoshi Sakao, Takayuki Tsuji, Naro Ohashi, Akihiko Kato, Hiroaki Miyajima, Hideo Yasuda
A 30-year-old woman with proteinuria first noted at 26 weeks of gestation was admitted to undergo further evaluation. A renal biopsy revealed membranous nephropathy (MN). There was no evidence of any secondary MN. Prednisolone was initiated 6 months after delivery. Four months later, her urine protein became negative. Enhanced granular staining for thrombospondin type-1 domain-containing 7A (THSD7A) in the glomeruli was retrospectively detected in a biopsy specimen. A literature review revealed that 60% of cases of THSD7A-related MN occurred in women of childbearing age...
2016: Internal Medicine
Jing Xu, Xiaofan Hu, Jingyuan Xie, Nan Chen
BACKGROUND: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults, accounting for about 20.0% of all NS cases. With an increasing prevalence, especially in the elderly, it has received great attention in Asia. SUMMARY: Recently, the prevalence of idiopathic MN (IMN) has significantly increased among the elderly people in Asia and other places in the world. Although the exact mechanism of IMN remains unveiled, the identification of new antigens such as PLA2R and THSD7A has greatly enhanced our understanding of its pathogenesis...
September 2015: Kidney Diseases
Lawrence Yu-Min Liu, Min-Hsuan Lin, Zih-Yin Lai, Jie-Peng Jiang, Yi-Ching Huang, Li-En Jao, Yung-Jen Chuang
BACKGROUND: Development of neural and vascular systems displays astonishing similarities among vertebrates. This parallelism is under a precise control of complex guidance signals and neurovascular interactions. Previously, our group identified a highly conserved neural protein called thrombospondin type I domain containing 7A (THSD7A). Soluble THSD7A promoted and guided endothelial cell migration, tube formation and sprouting. In addition, we showed that thsd7a could be detected in the nervous system and was required for intersegmental vessels (ISV) patterning during zebrafish development...
August 2, 2016: Journal of Biomedical Science
Elion Hoxha, Laurence H Beck, Thorsten Wiech, Nicola M Tomas, Christian Probst, Swantje Mindorf, Catherine Meyer-Schwesinger, Gunther Zahner, Phillip R Stahl, Ruth Schöpper, Ulf Panzer, Sigrid Harendza, Udo Helmchen, David J Salant, Rolf A K Stahl
Thrombospondin type 1 domain-containing 7A (THSD7A) is a target antigen identified in adult membranous nephropathy (MN) along with the major antigen phospholipase A2 receptor 1 (PLA2R1). The prevalence of THSD7A-Ab-positive patients is unknown, and it is unclear whether the clinical presentation differs between patients positive for PLA2R1-Ab or THSD7A-Ab. We screened serum samples of 1276 patients with MN from three different cohorts for the presence of THSD7A-Ab by Western blot analysis and a newly developed indirect immunofluorescence test (IFT)...
February 2017: Journal of the American Society of Nephrology: JASN
Nicola M Tomas, Elion Hoxha, Anna T Reinicke, Lars Fester, Udo Helmchen, Jens Gerth, Friederike Bachmann, Klemens Budde, Friedrich Koch-Nolte, Gunther Zahner, Gabriele Rune, Gerard Lambeau, Catherine Meyer-Schwesinger, Rolf A K Stahl
Membranous nephropathy (MN) is the most common cause of nephrotic syndrome in adults, and one-third of patients develop end-stage renal disease (ESRD). Circulating autoantibodies against the podocyte surface antigens phospholipase A2 receptor 1 (PLA2R1) and the recently identified thrombospondin type 1 domain-containing 7A (THSD7A) are assumed to cause the disease in the majority of patients. The pathogenicity of these antibodies, however, has not been directly proven. Here, we have reported the analysis and characterization of a male patient with THSD7A-associated MN who progressed to ESRD and subsequently underwent renal transplantation...
July 1, 2016: Journal of Clinical Investigation
Elion Hoxha, Thorsten Wiech, Phillip R Stahl, Gunther Zahner, Nicola M Tomas, Catherine Meyer-Schwesinger, Ulrich Wenzel, Matthias Janneck, Oliver M Steinmetz, Ulf Panzer, Sigrid Harendza, Rolf A K Stahl
No abstract text is available yet for this article.
May 19, 2016: New England Journal of Medicine
Jean M Francis, Laurence H Beck, David J Salant
Lessons from an animal model that faithfully resembles human membranous nephropathy (MN) have informed our understanding of the pathogenesis of this organ-specific autoimmune disease and common cause of nephrotic syndrome. After it was established that the subepithelial immune deposits that characterize experimental MN form in situ when circulating antibodies bind to an intrinsic podocyte antigen, it was merely a matter of time before the human antigen was identified. The M-type phospholipase A2 receptor 1 (PLA2R) represents the major target antigen in primary MN, and thrombospondin type 1 domain-containing 7A (THSD7A) was more recently identified as a minor antigen...
July 2016: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
M Ahmad, S S Nongmaithem, G V Krishnaveni, C H D Fall, C S Yajnik, G R Chandak
No abstract text is available yet for this article.
April 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
S Nizamuddin, P Govindaraj, S Saxena, M Kashyap, A Mishra, S Singh, H Rotti, R Raval, J Nayak, B K Bhat, B V Prasanna, V R Dhumal, S Bhale, K S Joshi, A P Dedge, R Bharadwaj, G G Gangadharan, S Nair, P M Gopinath, B Patwardhan, P Kondaiah, K Satyamoorthy, M S Valiathan, K Thangaraj
No abstract text is available yet for this article.
April 2016: International Journal of Obesity: Journal of the International Association for the Study of Obesity
Christopher P Larsen, L Nicholas Cossey, Laurence H Beck
Thrombospondin type I domain-containing 7A (THSD7A) is a known antigenic target of autoantibodies leading to primary membranous glomerulopathy and was reported to account for ~10% of phospholipase A2 receptor (PLA2R)-negative membranous glomerulopathy. It has been proposed that PLA2R and THSD7A autoantibodies are mutually exclusive in membranous glomerulopathy. We validated an immunohistochemical assay to investigate for THSD7A-associated membranous glomerulopathy and utilized it in 258 consecutive native kidney biopsies, which showed membranous glomerulopathy in our laboratory, with the exception of membranous lupus nephritis...
April 2016: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
Rongcan Luo, Yongqing Wang, Peng Xu, Guangming Cao, Yangyu Zhao, Xuan Shao, Yu-xia Li, Cheng Chang, Chun Peng, Yan-ling Wang
Preeclampsia, a relatively common pregnancy disorder, is a major contributor to maternal mortality and morbidity worldwide. An elevation in microRNA-210 (miR-210) expression in the placenta has been reported to be associated with preeclampsia. Our bioinformatic analysis showed that thrombospondin type I domain containing 7A (THSD7A) is a predicted target for miR-210. The aim of this study was to determine whether miR-210 is involved in preeclampsia through its targeting of THSD7A in human placental trophoblasts...
2016: Scientific Reports
S Nizamuddin, P Govindaraj, S Saxena, M Kashyap, A Mishra, S Singh, H Rotti, R Raval, J Nayak, B K Bhat, B V Prasanna, V R Dhumal, S Bhale, K S Joshi, A P Dedge, R Bharadwaj, G G Gangadharan, S Nair, P M Gopinath, B Patwardhan, P Kondaiah, K Satyamoorthy, M S Valiathan, K Thangaraj
Body mass index (BMI) is a non-invasive measurement of obesity. It is commonly used for assessing adiposity and obesity-related risk prediction. Genetic differences between ethnic groups are important factors, which contribute to the variation in phenotypic effects. India inhabited by the first out-of-Africa human population and the contemporary Indian populations are admixture of two ancestral populations; ancestral north Indians (ANI) and ancestral south Indians (ASI). Although ANI are related to Europeans, ASI are not related to any group outside Indian-subcontinent...
November 2015: International Journal of Obesity: Journal of the International Association for the Study of Obesity
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