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https://www.readbyqxmd.com/read/28329950/-progress-in-research-of-association-between-sleep-duration-and-type-2-diabetes
#1
H B Wu, L Yang, M Yu, J M Zhong, R Y Hu
Diabetes has become the world' s major public health problem in the 21(th) century. Increasing attention has been paid to the importance of healthy sleep abroad, whereas less attention has been paid to it in China. Through literature study, this paper summarizes the current status of epidemiology and laboratory research on the relationship between sleep duration and incidence of type 2 diabetes, insulin sensitivity and blood glucose control both at home and abroad, and introduces the underlying mechanisms in order to provide evidence for further studies and the prevention and management of diabetes...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28329947/-air-pollution-and-adverse-birth-outcome-in-china-a-comprehensive-review
#2
P F Zhu, Y Zhang, J Ban, T T Li, X M Shi
Objective: To summarize the progress in the research of the association between air pollution and adverse birth outcomes in China. Methods: A literature retrieval was conducted by using the databases of CNKI, Wanfang, Pubmed, Science Direct, and Web of Science to select relevant research papers published before 30(th), June 2016 in China according to inclusion criteria. Finally, 27 papers were included in analysis. Results: Exposure to particulate matter (PM(10)), sulfur dioxide (SO(2)), nitrogen dioxide (NO(2)), total suspended particles (TSP) during pregnancy might increase risk for low birth weight; exposure to PM(10), SO(2), NO(2) during pregnancy might increase risk for premature birth; and exposure to SO(2), NO(2), ozone (O(3)), and PM(10) during pregnancy might increase risk for congenital heart diseases and other birth defects...
March 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28328074/the-13-th-winter-conference-on-medicinal-and-bioorganic-chemistry
#3
Scott D Williams
The Medicinal and Bioorganic Chemistry Foundation (MBCF) hosted its 13(th) biannual Winter Conference on Medicinal and Bioorganic Chemistry (WCMBC) this past January 22(nd) -26(th) in Steamboat Springs, Colorado (USA). The gathering this year kept true to the tradition of this conference series, with an impressive lineup of presenters from both academia and industry. With about 125 delegates, the conference took all the advantages of a mid-sized gathering: a sufficiently wide spectrum of scientists in attendance, yet an intimate atmosphere conducive to solid networking and frank, open discussions...
March 22, 2017: ChemMedChem
https://www.readbyqxmd.com/read/28327619/il-36%C3%AE-signaling-controls-the-induced-regulatory-t-cell-th9-cell-balance-via-nf%C3%AE%C2%BAb-activation-and-stat-transcription-factors
#4
A Harusato, H Abo, V L Ngo, S W Yi, K Mitsutake, S Osuka, J E Kohlmeier, J D Li, A T Gewirtz, A Nusrat, T L Denning
Regulatory and effector T helper (Th) cells are abundant at mucosal surfaces, especially in the intestine, where they control the critical balance between tolerance and inflammation. However, the key factors that reciprocally dictate differentiation along these specific lineages remain incompletely understood. Here we report that the interleukin-1 (IL-1) family member IL-36γ signals through IL-36 receptor, myeloid differentiation primary response gene 88, and nuclear factor-κBp50 in CD4(+) T cells to potently inhibit Foxp3-expressing induced regulatory T cell (Treg) development, while concomitantly promoting the differentiation of Th9 cells via a IL-2-STAT5- (signal transducer and activator of transcription factor 5) and IL-4-STAT6-dependent pathway...
March 22, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28327591/gully-evolution-and-geomorphic-adjustments-of-badlands-to-reforestation
#5
J A Ballesteros Cánovas, M Stoffel, J F Martín-Duque, C Corona, A Lucía, J M Bodoque, D R Montgomery
Badlands and gullied areas are among those geomorphic environments with the highest erosion rates worldwide. Nevertheless, records of their evolution and their relations with anthropogenic land transformation are scarcer. Here we combine historical data with aerial photographs and tree-ring records to reconstruct the evolution of a badland in a Mediterranean environment of Central Spain. Historical sources suggest an anthropogenic origin of this badland landscape, caused by intense quarrying activities during the 18(th) century...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28327585/estimated-daily-intake-and-cumulative-risk-assessment-of-phthalates-in-the-general-taiwanese-after-the-2011-dehp-food-scandal
#6
Jung-Wei Chang, Ching-Chang Lee, Wen-Harn Pan, Wei-Chun Chou, Han-Bin Huang, Hung-Che Chiang, Po-Chin Huang
A food scandal occurred in Taiwan in 2011 because the DEHP (di-2-ethylhexyl phthalate) had been intentionally used in food products. We assessed the daily intakes (DIs) and cumulative risk of phthalates in Taiwan's general population after the scandal. The DIs of 6 phthalates, including di-n-butyl phthalate (DnBP), di-iso-butyl phthalate (DiBP), and DEHP, were evaluated using urinary phthalate metabolites. Hazard quotients of phthalates classified as affecting the reproductive (HQrep) and hepatic (HQhep) systems were assessed using cumulative approach...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28326903/4-th-international-workshop-on-lung-health-poster-winners
#7
(no author information available yet)
No abstract text is available yet for this article.
April 2017: COPD
https://www.readbyqxmd.com/read/28326902/4-th-international-workshop-on-lung-health-rising-stars-abstracts
#8
(no author information available yet)
No abstract text is available yet for this article.
April 2017: COPD
https://www.readbyqxmd.com/read/28326743/dopamine-receptors-modulate-t-lymphocytes-via-inhibition-of-camp-creb-signaling-pathway
#9
(no author information available yet)
OBJECTIVES: We have previously reported that dopamine D2-like receptors including D2, D3 and D4 receptors are more important in mediating modulation of T cells than dopamine D1-like receptors (D1 and D5 receptors). Here we aimed to clarify the role of D2-like receptors in regulation of differentiation and function of T lymphocyte subsets, including helper T (Th)1, Th2, Th17 and regulatory T (Treg) cells. METHODS: Lymphocytes, separated from the mesenteric lymph nodes of mice, were stimulated with concanavalin A (Con A) and treated with the D2-like receptor agonist quinpirole or the antagonist haloperidol...
December 22, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28326646/effect-of-tempol-on-the-prevention-of-irradiation-induced-mucositisin-miniature-pigs
#10
Liang Hu, Yijuan Wang, Ana P Cotrim, Zhao Zhu, Runtao Gao, Changyu Zheng, Corinne M Goldsmith, Luyuan Jin, Chunmei Zhang, James B Mitchell, Bruce J Baum, Songlin Wang
OBJECTIVE: The goals of this study were to (i) establish a useful miniature pig (minipig) model for irradiation-induced oral mucositis and (ii) evaluate the effect of Tempol to prevent its development. METHODS AND MATERIALS: Minipigs were irradiated with 6Gy for 5 consecutive days targeting the entire oral cavity. To prevent radiation damage minipigs were treated with 30 mg/kg Tempol 10 minutes before irradiation (n=4), while, the radiation-alone group was similarly injected with saline (n=4)...
March 22, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28326627/obituary-thomas-earl-starzl-the-father-of-transplantation-march-11-1926-march-4-2017-to-be-published-in-esot-newsletter-transplant-international
#11
Jan P Lerut
March 2016…the transplant community celebrated with pomp the 90(th) birthday of transplantation pioneer, Th. E. Starzl. More than 400 surgeons and scientists originating from all over the United States and from all five continents met in Pittsburgh to pay tribute to their mentor, teacher and friend. The 'Starzl family at large' experienced a once in a lifetime event ending with a thoughtful, but typical (Fig. 1) 'Starzl speech' about past and future, including a humoristic but realistic view on life and ageing...
March 22, 2017: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/28326606/physical-activity-sedentary-time-and-bone-strength-from-childhood-to-early-adulthood-a-mixed-longitudinal-hr-pqct-study
#12
Leigh Gabel, Heather M Macdonald, Lindsay Nettlefold, Heather A McKay
Bone strength is influenced by bone geometry, density, and bone microarchitecture, which adapt to increased mechanical loads during growth. Physical activity (PA) is essential for optimal bone strength accrual; however, less is known about how sedentary time influences bone strength and its determinants. Thus, our aim was to investigate the prospective associations between PA, sedentary time, and bone strength and its determinants during adolescence. We used HR-pQCT at distal tibia (8% site) and radius (7% site) in 173 girls and 136 boys (aged 9 to 20 years at baseline)...
March 22, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28326539/isotopic-niche-partitioning-between-two-apex-predators-over-time
#13
M Drago, L Cardona, V Franco-Trecu, E A Crespo, D Vales, F Borella, L Zenteno, E M Gonzáles, P Inchausti
1.Stable isotope analyses have become an important tool in reconstructing diets, analyzing resource use patterns, elucidating trophic relations among predators and understanding the structure of food webs. 2.Here, we use stable carbon and nitrogen isotope ratios in bone collagen to reconstruct and compare the isotopic niches of adult South American fur seals (Arctocephalus australis; n = 86) and sea lions (Otaria flavescens; n = 49) -two otariid species with marked morphological differences- in the Río de la Plata estuary (Argentina - Uruguay) and the adjacent Atlantic Ocean during the second half of the 20(th) century and the beginning of the 21(st) century...
March 22, 2017: Journal of Animal Ecology
https://www.readbyqxmd.com/read/28325790/dopamine-terminals-from-the-ventral-tegmental-area-gate-intrinsic-inhibition-in-the-prefrontal-cortex
#14
William C Buchta, Stephen V Mahler, Benjamin Harlan, Gary S Aston-Jones, Arthur C Riegel
Spike frequency adaptation (SFA or accommodation) and calcium-activated potassium channels that underlie after-hyperpolarization potentials (AHP) regulate repetitive firing of neurons. Precisely how neuromodulators such as dopamine from the ventral tegmental area (VTA) regulate SFA and AHP (together referred to as intrinsic inhibition) in the prefrontal cortex (PFC) remains unclear. Using whole cell electrophysiology, we measured intrinsic inhibition in prelimbic (PL) layer 5 pyramidal cells of male adult rats...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28325591/global-scanning-of-antihistamines-in-the-environment-analysis-of-occurrence-and-hazards-in-aquatic-systems
#15
Lauren A Kristofco, Bryan W Brooks
Concentration of the global population is increasingly occurring in megacities and other developing regions, where access to medicines is increasing more rapidly than waste management systems are implemented. Because freshwater and coastal systems are influenced by wastewater effluent discharges of differential quality, exposures in aquatic systems must be considered. Here, we performed a global scanning assessment of antihistamines (AHs), a common class of medicines, in surface waters and effluents. Antihistamines were identified, literature occurrence and ecotoxicology data on AHs collated, therapeutic hazard values (THVs) calculated, and environmental exposure distributions (EEDs) of AHs compared to ecotoxicity thresholds and drug specific THVs to estimate hazards in surface waters and effluents...
March 18, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28324967/a-data-model-to-support-the-evaluation-of-coordinating-care-eu-programmes-in-the-context-of-the-act-programme
#16
P Natsiavas, D Filos, I Chouvarda, C Maramis, R van der Heijden, H Schonenberg, S Pauws, C Bescos, N Maglaveras
Advancing Care Coordination and Telehealth Deployment (ACT) is a European Union (EU) project, completed last October, which has developed a framework for evaluating and improving pioneering health care programs regarding coordinating care and telehealth (CC & TH) across specific EU regions. In this paper we present the key design decisions of the project's data model and the challenges faced. We focus on the definition of the multi-dimensional indicators in order to overcome data incompleteness and heterogeneity issues...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28324687/variation-of-natural-radionuclides-in-non-ferrous-fayalite-slags-during-a-one-month-production-period
#17
Tom Croymans, Indy Vandael Schreurs, Mikael Hult, Gerd Marissens, Guillaume Lutter, Heiko Stroh, Sonja Schreurs, Wouter Schroeyers
The European Basic Safety Standards (EU-BSS) describes a set of NORM (Naturally Occurring Radioactive Material)-processing industries which produce residues known to be possibly enriched in NORs (Naturally Occurring Radionuclides). These residues can be used as a component in building materials aimed for public usage. The industrial processes, in which the residues are produced, are often complex and total monitoring can be challenging especially when the origin of the used raw materials varies. In this study the NORs present in non-ferrous fayalite slags of a secondary smelter facility, a NORM-processing industry according to the EU-BSS, were monitored daily during a one-month production period...
March 18, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28324618/thermogelling-chitosan-lactate-hydrogel-improves-functional-recovery-after-a-c2-spinal-cord-hemisection-in-rat
#18
Katarzyna Nawrotek, Tanguy Marqueste, Zofia Modrzejewska, Roman Zarzycki, Agnieszka Rusak, Patrick Decherchi
The present study was designed to provide an appropriate micro-environment for regenerating axotomized neurons and proliferating/migrating cells. Because of its intrinsic permissive properties, biocompatibility and biodegradability, we chose to evaluate the therapeutic effectiveness of a chitosan-based biopolymer. The biomaterial toxicity was measured through in vitro test based on fibroblast cell survival on thermogelling chitosan lactate hydrogel substrate and then polymer was implanted into a C2 hemisection of the rat spinal cord...
March 21, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28324192/the-presence-of-human-papillomavirus-hpv-in-placenta-and-or-cord-blood-might-result-in-th2-polarization
#19
H-M Koskimaa, A Paaso, M J P Welters, S Grénman, K Syrjänen, S H van der Burg, S Syrjänen
The purpose of this study was to evaluate if an early exposure to human papillomavirus (HPV) during the prenatal period or infancy could result in HPV16-specific T helper (Th) responses resembling those of adults with HPV-induced lesions. We tested HPV16-specific cell-mediated immunity (CMI) in children born with HPV-positive umbilical cord blood and/or placenta or having persistent oral HPV infection and in constantly oral HPV-negative controls. Peripheral blood mononuclear cells from 33 children from the Finnish HPV Family Study cohort (mean age 14...
March 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28324179/interactions-of-phosphate-solubilising-microorganisms-with-natural-rare-earth-phosphate-minerals-a-study-utilizing-western-australian-monazite
#20
Melissa K Corbett, Jacques J Eksteen, Xi-Zhi Niu, Jean-Philippe Croue, Elizabeth L J Watkin
Many microbial species are capable of solubilising insoluble forms of phosphate and are used in agriculture to improve plant growth. In this study, we apply the use of known phosphate solubilising microbes (PSM) to the release of rare-earth elements (REE) from the rare-earth phosphate mineral, monazite. Two sources of monazite were used, a weathered monazite and mineral sand monazite, both from Western Australia. When incubated with PSM, the REE were preferentially released into the leachate. Penicillum sp...
March 21, 2017: Bioprocess and Biosystems Engineering
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