Karim Mithani, Oliver L Richards, Mark Ebden, Noor Malik, Ladina Greuter, Hrishikesh Suresh, Farbod Niazi, Flavia Venetucci Gouveia, Elysa Widjaja, Shelly Weiss, Elizabeth Donner, Hiroshi Otsubo, Ayako Ochi, Puneet Jain, Ivanna Yau, Elizabeth N Kerr, James T Rutka, James M Drake, Alexander G Weil, George M Ibrahim
BACKGROUND AND OBJECTIVES: Gelastic seizures due to hypothalamic hamartomas (HH) are challenging to treat, in part due to an incomplete understanding of seizure propagation pathways. Although magnetic resonance imaging-guided laser interstitial thermal therapy (MRgLITT) is a promising intervention to disconnect HH from ictal propagation networks, the optimal site of ablation to achieve seizure freedom is not known. In this study, we investigated intraoperative post-ablation changes in resting-state functional connectivity to identify large-scale networks associated with successful disconnection of HH...
May 1, 2024: NeuroImage: Clinical