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amino acids imbalance

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https://www.readbyqxmd.com/read/29868589/body-weight-loss-and-tissue-wasting-in-late-middle-aged-mice-on-slightly-imbalanced-essential-non-essential-amino-acids-diet
#1
Giovanni Corsetti, Evasio Pasini, Claudia Romano, Riccardo Calvani, Anna Picca, Emanuele Marzetti, Vincenzo Flati, Francesco S Dioguardi
Objective: Inadequate protein intake can impair protein balance thus leading to skeletal muscle atrophy, impaired body growth, and functional decline. Foods provide both non-essential (NEAAs) and essential amino acids (EAAs) that may convey different metabolic stimuli to specific organs and tissues. In this study, we sought to evaluate the impact of six diets, with various EAA/NEAA blends, on body composition and the risk of developing tissue wasting in late middle-aged male mice. Methods: Six groups of late middle-aged male mice were fed for 35 days with iso-nutrients, iso-caloric, and iso-nitrogenous special diets containing different EAA/NEAA ratios ranging from 100/0% to 0/100%...
2018: Frontiers in Medicine
https://www.readbyqxmd.com/read/29867095/metabolic-patterns-in-insulin-resistant-male-hypogonadism
#2
Federica Gevi, Giuseppina Fanelli, Lello Zolla
Male hypogonadism associated with insulin resistance (IR) very often leads to metabolic syndrome, at variance with hypogonadism in its first stadium of insulin sensitivity (IS). A plasma metabolomic investigation of these patients can provide useful information in comparison with the values of IS patients. To this aim plasma from insulin-resistant males with hypogonadism were analysed by using ultra high-performance liquid chromatography (UHPLC) and high-resolution mass spectrometry (HRMS). Thus, metabolites were compared to the controls through multivariate statistical analysis and grouped by metabolic pathways...
April 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29864919/taurine-enhances-the-protective-effect-of-dexmedetomidine-on-sepsis-induced-acute-lung-injury-via-balancing-the-immunological-system
#3
Wei Zhao, Ling Jia, Hui-Jing Yang, Xiang Xue, Wei-Xiao Xu, Jian-Qin Cai, Rui-Juan Guo, Chang-Chun Cao
Sepsis, an overwhelming systemic inflammatory disease, is the leading cause of acute lung injury (ALI). Despite plenty of researches have been done, effective drugs treating septic ALI are still eagerly needed in the clinic. Dexmedetomidine (Dex), a potent alpha-2 adrenoreceptor agonist, has been reported to possess antioxidant, anti-apoptosis and anti-inflammatory abilities. Taurine, a kind of intracellular free amino acid, has been used to treat various diseases. This study aimed to explore the combination effect of Dex and Taurine on septic ALI and the underlying mechanism in vivo...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29800733/dissecting-metabolic-behavior-of-lipid-over-producing-strain-of-mucor-circinelloides-through-genome-scale-metabolic-network-and-multi-level-data-integration
#4
Wanwipa Vongsangnak, Amornthep Kingkaw, Junhuan Yang, Yuanda Song, Kobkul Laoteng
Lipid accumulation is an important cellular process of oleaginous microorganisms. To dissect metabolic behavior of oleaginous Zygomycetes, the lipid over-producing strain, Mucor circinelloides WJ11, was subjected for omics-scale analysis. The genome annotation was improved and used for construction of genome-scale metabolic network of WJ11 strain. Then, the quality of the metabolic network was enhanced by incorporating gene and protein expression data. In addition to the known oleaginous genes, our results showed a number of newly identified unique genes of WJ11 strain, which involved in central carbon metabolism, lipid, amino acid and nitrogen metabolisms...
May 22, 2018: Gene
https://www.readbyqxmd.com/read/29797533/making-glycine-methyl-ester-chiral
#5
Dennis Gerbig, Sarina Desch, Peter Richard Schreiner
Here we demonstrate that the simple achiral amino acid glycine as its methyl ester inherits the chiral imprint of methyl lactate upon complexation, resulting in induced vibrational optical activity of the methylene C-H bonds. To mimick conditions of ices on comets that are considered long-term reaction as well as storage entities for (organic) molecules, we employ the matrix isolation technique in conjunction with vibrational circular dichroism spectroscopy and density functional theory computations. The observed chirality transfer likely is a key element for the realization of concepts rationalizing chirogenesis, i...
May 24, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29769708/maternal-supraphysiological-hypercholesterolemia-associates-with-endothelial-dysfunction-of-the-placental-microvasculature
#6
Bárbara Fuenzalida, Bastián Sobrevia, Claudette Cantin, Lorena Carvajal, Rocío Salsoso, Jaime Gutiérrez, Susana Contreras-Duarte, Luis Sobrevia, Andrea Leiva
Maternal physiological or supraphysiological hypercholesterolemia (MPH, MSPH) occurs during pregnancy. MSPH is associated with foetal endothelial dysfunction and atherosclerosis. However, the potential effects of MSPH on placental microvasculature are unknown. The aim of this study was to determine whether MSPH alters endothelial function in the placental microvasculature both ex vivo in venules and arterioles from the placental villi and in vitro in primary cultures of placental microvascular endothelial cells (hPMEC)...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29769004/regulatory-role-of-amino-acids-in-pigs-fed-on-protein-restricted-diets
#7
Sung Woo Kim, Hongyu Chen, Wanpuech Parnsen
The high inclusion of dietary protein and the imbalance of amino acid (AA) composition in animal husbandry result in inefficient utilization of protein resources and increased nitrogen excretion. Therefore, an efficient approach to alleviate the nitrogen excretion and increase the utilization of protein resources is to formulate the AA-balance protein-restricted diet with crystalline AA supplementation. Nowadays, it is essential to thoroughly understand the regulatory mechanisms of AAs on body metabolism and their vital roles in protein-restricted diets...
May 16, 2018: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/29735415/interventions-targeting-glucocorticoid-kr%C3%A3-ppel-like-factor-15-branched-chain-amino-acid-signaling-improve-disease-phenotypes-in-spinal-muscular-atrophy-mice
#8
Lisa M Walter, Marc-Olivier Deguise, Katharina E Meijboom, Corinne A Betts, Nina Ahlskog, Tirsa L E van Westering, Gareth Hazell, Emily McFall, Anna Kordala, Suzan M Hammond, Frank Abendroth, Lyndsay M Murray, Hannah K Shorrock, Domenick A Prosdocimo, Saptarsi M Haldar, Mukesh K Jain, Thomas H Gillingwater, Peter Claus, Rashmi Kothary, Matthew J A Wood, Melissa Bowerman
The circadian glucocorticoid-Krüppel-like factor 15-branched-chain amino acid (GC-KLF15-BCAA) signaling pathway is a key regulatory axis in muscle, whose imbalance has wide-reaching effects on metabolic homeostasis. Spinal muscular atrophy (SMA) is a neuromuscular disorder also characterized by intrinsic muscle pathologies, metabolic abnormalities and disrupted sleep patterns, which can influence or be influenced by circadian regulatory networks that control behavioral and metabolic rhythms. We therefore set out to investigate the contribution of the GC-KLF15-BCAA pathway in SMA pathophysiology of Taiwanese Smn-/- ;SMN2 and Smn2B/- mouse models...
May 4, 2018: EBioMedicine
https://www.readbyqxmd.com/read/29724166/surveying-alignment-free-features-for-ortholog-detection-in-related-yeast-proteomes-by-using-supervised-big-data-classifiers
#9
Deborah Galpert, Alberto Fernández, Francisco Herrera, Agostinho Antunes, Reinaldo Molina-Ruiz, Guillermin Agüero-Chapin
BACKGROUND: The development of new ortholog detection algorithms and the improvement of existing ones are of major importance in functional genomics. We have previously introduced a successful supervised pairwise ortholog classification approach implemented in a big data platform that considered several pairwise protein features and the low ortholog pair ratios found between two annotated proteomes (Galpert, D et al., BioMed Research International, 2015). The supervised models were built and tested using a Saccharomycete yeast benchmark dataset proposed by Salichos and Rokas (2011)...
May 3, 2018: BMC Bioinformatics
https://www.readbyqxmd.com/read/29705631/metabolic-switching-in-the-hypoglycemic-and-antitumor-effects-of-metformin-on-high-glucose-induced-hepg2-cells
#10
Yan Lv, Na Tian, Junsong Wang, Minghua Yang, Lingyi Kong
Metformin, a widely prescribed drug for the management of type 2 diabetes mellitus, has potential anticancer effect. Diabetes patients regularly taking metformin have been reported with decreased cancer risk and improved cancer prognosis in recent years. A cell model of high glucose induced HepG2 cells was conducted to mimic insulin resistance, and a 1 H NMR-based metabolomics approach in conjunction with molecular biology was performed to investigate the metabolic changes of high glucose induced HepG2 cells in response to different doses of metformin treatment and to study the differences and links between hypoglycemic and antitumor effects of metformin...
July 15, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29705267/branched-chain-amino-acid-depletion-conditions-bone-marrow-for-hematopoietic-stem-cell-transplantation-avoiding-amino-acid-imbalance-associated-toxicity
#11
Adam C Wilkinson, Maiko Morita, Hiromitsu Nakauchia, Satoshi Yamazaki
Hematopoietic stem cells (HSCs) are used clinically in bone marrow (BM) transplantation due to their unique ability to reform the entire hematopoietic system. Recently, we reported that HSCs are highly sensitive to valine, one of the three branched-chain amino acids (BCAAs) in addition to isoleucine and leucine. Dietary depletion of valine could even be used as a conditioning regimen for HSC transplantation. Here, we report that HSCs are highly sensitive to the balance of BCAAs, with both proliferation and survival reduced by BCAA imbalance...
April 26, 2018: Experimental Hematology
https://www.readbyqxmd.com/read/29677539/fibromyalgia-and-nutrition-therapeutic-possibilities
#12
REVIEW
Geir Bjørklund, Maryam Dadar, Salvatore Chirumbolo, Jan Aaseth
Fibromyalgia (FM) is a complex chronic condition of unknown etiology, characterized by deep and widespread pain, sleep problems, cognitive impairment, fatigue, and other well-known functional symptoms. Recently, it has been proposed that an imbalance of nutritive components, including essential metal ions and vitamins, might play a critical role in the development of FM. Muscle pain has been associated with deficiencies in amino acids, magnesium, selenium, vitamins B and D, as well as with the harmful effects of heavy metals, such as mercury, cadmium, and lead...
July 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29657030/rewiring-of-glutamine-metabolism-is-a-bioenergetic-adaptation-of-human-cells-with-mitochondrial-dna-mutations
#13
Qiuying Chen, Kathryne Kirk, Yevgeniya I Shurubor, Dazhi Zhao, Andrea J Arreguin, Ifrah Shahi, Federica Valsecchi, Guido Primiano, Elizabeth L Calder, Valerio Carelli, Travis T Denton, M Flint Beal, Steven S Gross, Giovanni Manfredi, Marilena D'Aurelio
Using molecular, biochemical, and untargeted stable isotope tracing approaches, we identify a previously unappreciated glutamine-derived α-ketoglutarate (αKG) energy-generating anaplerotic flux to be critical in mitochondrial DNA (mtDNA) mutant cells that harbor human disease-associated oxidative phosphorylation defects. Stimulating this flux with αKG supplementation enables the survival of diverse mtDNA mutant cells under otherwise lethal obligatory oxidative conditions. Strikingly, we demonstrate that when residual mitochondrial respiration in mtDNA mutant cells exceeds 45% of control levels, αKG oxidative flux prevails over reductive carboxylation...
May 1, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29533943/high-concentrate-diet-induced-change-of-cellular-metabolism-leads-to-decreases-of-immunity-and-imbalance-of-cellular-activities-in-rumen-epithelium
#14
Zhongyan Lu, Hong Shen, Zanming Shen
BACKGROUND/AIMS: In animals, the immune and cellular processes of tissue largely depend on the status of local metabolism. However, in the rumen epithelium, how the cellular metabolism affects epithelial immunity, and cellular processes, when the diet is switched from energy-rich to energy-excess status, with regard to animal production and health, have not as yet been reported. METHODS: RNA-seq was applied to compare the biological processes altered by an increase of dietary concentration from 10% to 35% with those altered by an increase of dietary concentration from 35% to 65% (dietary concentrate: the non-grass component in diet, including corn, soya bean meal and additive...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29526799/pharmacokinetics-and-pharmacodynamics-of-pegylated-truncated-human-cystathionine-beta-synthase-for-treatment-of-homocystinuria
#15
Tomas Majtan, Erez M Bublil, Insun Park, Erland Arning, Teodoro Bottiglieri, Frank Glavin, Jan P Kraus
AIMS: PEGylated human truncated cystathionine beta-synthase, lacking the C-terminal regulatory domain (PEG-CBS), is a promising preclinical candidate for enzyme replacement therapy in homocystinuria (HCU). It was designed to function as a metabolic sink to decrease the severely elevated plasma and tissue homocysteine concentrations. In this communication, we evaluated pharmacokinetics (PK), pharmacodynamics (PD) and sub-chronic toxicity of PEG-CBS in homocystinuric mice, wild type rats and monkeys to estimate the minimum human efficacious dose for clinical trials...
May 1, 2018: Life Sciences
https://www.readbyqxmd.com/read/29506456/antigonadal-and-endocrine-disrupting-activities-of-lambda-cyhalothrin-in-female-rats-and-its-attenuation-by-taurine
#16
Rini Ghosh, Bhaswati Banerjee, Tuhina Das, Kuladip Jana, Sujata Maiti Choudhury
Lambda cyhalothrin (LCT) is a type II pyrethroid with a wide range of agricultural, industrial, and household uses. Taurine is a nonprotein sulfur containing amino acid as well as a well-known antioxidant and has valuable clinical applications in the detoxification of xenobiotics. The present study evaluated the effect of LCT on the reproductive and endocrine systems of female rats and determined whether taurine might alter these effects. Sexually mature female rats were administered LCT at two different dosages (6...
March 2018: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29454986/nano-sized-tio-2-ntio-2-induces-metabolic-perturbations-in-physarum-polycephalum-macroplasmodium-to-counter-oxidative-stress-under-dark-conditions
#17
Zhi Zhang, Zhi Cheng Liang, Jian Hua Zhang, Sheng Li Tian, Jun Le Qu, Jiao Ning Tang, Shi De Liu
Nano-sized TiO2 (nTiO2 ) exerts an oxidative effect on cells upon exposure to solar or UV irradiation and ecotoxicity of the nTiO2 is an urgent concern. Little information is available regarding the effect of TiO2 on cells under dark conditions. Metabolomics is a unique approach to the discovery of biomarkers of nTiO2 cytotoxicity, and leads to the identification of perturbed metabolic pathways and the mechanism underlying nTiO2 toxicity. In the present study, gas chromatography mass spectrometry (GC/MS)-based metabolomics was performed to investigate the effect of nTiO2 on sensitive cells (P...
June 15, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29380062/the-profiling-of-plasma-free-amino-acids-and-the-relationship-between-serum-albumin-and-plasma-branched-chain-amino-acids-in-chronic-liver-disease-a-single-center-retrospective-study
#18
Akitoshi Sano, Eiji Kakazu, Tatsuki Morosawa, Jun Inoue, Takayuki Kogure, Masashi Ninomiya, Tomoaki Iwata, Teruyuki Umetsu, Takuya Nakamura, Satoshi Takai, Tooru Shimosegawa
BACKGROUND: It is poorly understood how an imbalance of plasma-free amino acids (PFAAs) occurs and how the imbalance shows an association with the serum albumin (sAlb) level during the progression of chronic liver disease (CLDs). The aim of this study is to elucidate the profiles of PFAAs and the relationship between sAlb and PFAAs in recent patients with CLDs during the progression. METHODS: We retrospectively evaluated the 1569 data of PFAAs data obtained from 908 patients with various CLDs (CHC, CHB...
January 27, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29327380/effects-of-deficiency-and-surplus-dietary-threonine-on-reproductive-performance-of-primiparous-pregnant-gilts
#19
M Shi, T Liu, T Li, H Wang, T Yuan, D Li, J Wang
Dietary threonine imbalance is known to impair reproductive performances of gestating sows, but the underlying mechanisms are largely unknown. In this study, effects of deficiency and surplus dietary threonine during gestation on reproductive performance, serum metabolites and hormones concentration, and colostral nutrient and immunoglobulin contents of primiparous sows were investigated. Ninety primiparous pregnant gilts were assigned to one of the three dietary treatments with different standardized ileal digestible threonine/lysine ratios at 0...
April 2018: Journal of Animal Physiology and Animal Nutrition
https://www.readbyqxmd.com/read/29319890/two-novel-unstable-hemoglobin-variants-due-to-in-frame-deletions-of-key-amino-acids-in-the-%C3%AE-globin-chain
#20
Karen G Scheps, Marcia Anahí Hasenahuer, Gustavo Parisi, Héctor M Targovnik, Eliana García, Ernesto Samuel Veber, Renée Crisp, Graciela Elena, Viviana Varela, María Silvina Fornasari
Hemoglobinopathies are the most common autosomal recessive disorders and are mostly inherited in a recessive manner. However, certain mutations can affect the globin chain stability, leading to dominant forms of thalassemia. The aim of this work was the molecular and structural characterization of two heterozygous in-frame deletions, leading to β-globin variants in pediatric patients in Argentina. The HBB gene of the probands and their parents was sequenced, and other markers of globin chain imbalance were analyzed...
January 10, 2018: European Journal of Haematology
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