keyword
https://read.qxmd.com/read/38536802/predicting-successful-weaning-from-mechanical-ventilation-by-reduction-in-positive-end-expiratory-pressure-level-using-machine-learning
#1
JOURNAL ARTICLE
Seyedmostafa Sheikhalishahi, Mathias Kaspar, Sarra Zaghdoudi, Julia Sander, Philipp Simon, Benjamin P Geisler, Dorothea Lange, Ludwig Christian Hinske
Weaning patients from mechanical ventilation (MV) is a critical and resource intensive process in the Intensive Care Unit (ICU) that impacts patient outcomes and healthcare expenses. Weaning methods vary widely among providers. Prolonged MV is associated with adverse events and higher healthcare expenses. Predicting weaning readiness is a non-trivial process in which the positive end-expiratory pressure (PEEP), a crucial component of MV, has potential to be indicative but has not yet been used as the target...
March 2024: PLOS Digit Health
https://read.qxmd.com/read/38536128/drug-induced-liver-injury-during-a-glaucoma-neuroprotection-clinical-trial
#2
JOURNAL ARTICLE
Aakriti Garg Shukla, George A Cioffi, Jeffrey M Liebmann
There are several ongoing, worldwide clinical trials with a cumulative target enrollment of over 1300 participants on the role of nicotinamide (a specific form of vitamin B3) as a therapeutic neuroprotective treatment for glaucoma. We describe a serious adverse event of drug-induced liver injury (DILI) likely related to the use of 3 grams/day nicotinamide in a glaucoma clinical trial (clinicaltrials.gov identifier: NCT05695027) based in the United States. This report is important to share with the medical community, as other participants in glaucoma nicotinamide trials globally may have similar adverse events and many patients are using nicotinamide as a health supplement without medical supervision...
March 28, 2024: Journal of Glaucoma
https://read.qxmd.com/read/38535090/machine-learning-identifies-higher-survival-profile-in-extracorporeal-cardiopulmonary-resuscitation
#3
JOURNAL ARTICLE
Ruben Crespo-Diaz, Julian Wolfson, Demetris Yannopoulos, Jason A Bartos
OBJECTIVES: Extracorporeal cardiopulmonary resuscitation (ECPR) has been shown to improve neurologically favorable survival in patients with refractory out-of-hospital cardiac arrest (OHCA) caused by shockable rhythms. Further refinement of patient selection is needed to focus this resource-intensive therapy on those patients likely to benefit. This study sought to create a selection model using machine learning (ML) tools for refractory cardiac arrest patients undergoing ECPR. DESIGN: Retrospective cohort study...
March 27, 2024: Critical Care Medicine
https://read.qxmd.com/read/38534531/validity-and-reliability-of-a-smartphone-application-for-home-measurement-of-four-meter-gait-speed-in-older-adults
#4
JOURNAL ARTICLE
Pei-An Lee, Clark DuMontier, Wanting Yu, Levi Ask, Junhong Zhou, Marcia A Testa, Dae Kim, Gregory Abel, Tom Travison, Brad Manor, On-Yee Lo
The four-meter gait speed (4MGS) is a recommended physical performance test in older adults but is challenging to implement clinically. We developed a smartphone application (App) with a four-meter ribbon for remote 4MGS testing at home. This study aimed to assess the validity and reliability of this smartphone App-based assessment of the home 4MGS. We assessed the validity of the smartphone App by comparing it against a gold standard video assessment of the 4MGS conducted by study staff visiting community-dwelling older adults and against the stopwatch-based measurement...
March 6, 2024: Bioengineering
https://read.qxmd.com/read/38533950/evaluations-of-artificial-intelligence-and-machine-learning-in-neurodiagnostics
#5
JOURNAL ARTICLE
Kristin Williams
This paper evaluates the ethical implications of utilizing artificial intelligence (AI) algorithms in neurological diagnostic examinations. Applications of AI technology have been utilized to aid in the determination of pharmacological dosages of gadolinium for brain lesion detection, localization of seizure foci, and the characterization of large vessel occlusion in ischemic stroke patients. Multiple subtypes of AI- machine learning (AI/ML) algorithms are analyzed as AI-assisted neurology utilizes supervised, unsupervised, artificial neural network (ANN), and deep neural network (DNN) learning models...
March 27, 2024: Journal of Neurophysiology
https://read.qxmd.com/read/38533163/rehabilitation-techniques-before-and-after-total-knee-arthroplasty-for-a-better-quality-of-life
#6
REVIEW
Sushmita Dutta, Ratnakar Ambade, Dhanashree Wankhade, Palak Agrawal
The most important gold standard treatment following advanced knee osteoarthritis is total knee arthroplasty. Following surgery of total knee replacement, the majority of patients report decreased pain and successful long-term results, but recovery is unpredictable, and most patients continue to exhibit muscle weakness in their lower limbs and functional limitations in comparison to similarly aged control individuals. The goal of this review article was to systematically review different articles containing controlled and randomized studies to find out the effectiveness of outpatient care postoperatively on short- and long-term functional recovery...
February 2024: Curēus
https://read.qxmd.com/read/38533032/metal-ion-stimulation-related-gene-signatures-correlate-with-clinical-and-immunologic-characteristics-of-glioma
#7
JOURNAL ARTICLE
Chengzhi Jiang, Binbin Zhang, Wenjuan Jiang, Pengtao Liu, Yujia Kong, Jianhua Zhang, Wenjie Teng
BACKGROUND: Environmental factors serve as one of the important pathogenic factors for gliomas. Yet people focus only on the effect of electromagnetic radiation on its pathogenicity, while metals in the environment are neglected. This study aimed to investigate the relationship between metal ion stimulation and the clinical characteristics and immune status of GM patients. METHODS: Firstly, mRNA expression profiles of GM patients and normal subjects were obtained from Chinese GM Genome Atlas (CGGA) and Gene Expression Omnibus (GEO) to identify differentially expressed metal ion stimulation-related genes(DEMISGs)...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38532927/structurally-constrained-and-pathology-aware-convolutional-transformer-generative-adversarial-network-for-virtual-histology-staining-of-human-coronary-optical-coherence-tomography-images
#8
JOURNAL ARTICLE
Xueshen Li, Hongshan Liu, Xiaoyu Song, Charles C Marboe, Brigitta C Brott, Silvio H Litovsky, Yu Gan
SIGNIFICANCE: There is a significant need for the generation of virtual histological information from coronary optical coherence tomography (OCT) images to better guide the treatment of coronary artery disease (CAD). However, existing methods either require a large pixel-wise paired training dataset or have limited capability to map pathological regions. AIM: The aim of this work is to generate virtual histological information from coronary OCT images, without a pixel-wise paired training dataset while capable of providing pathological patterns...
March 2024: Journal of Biomedical Optics
https://read.qxmd.com/read/38532639/automating-sedation-state-assessments-using-natural-language-processing
#9
JOURNAL ARTICLE
Aaron Conway, Jack Li, Mohammad Goudarzi Rad, Sebastian Mafeld, Babak Taati
INTRODUCTION: Common goals for procedural sedation are to control pain and ensure the patient is not moving to an extent that is impeding safe progress or completion of the procedure. Clinicians perform regular assessments of the adequacy of procedural sedation in accordance with these goals to inform their decision-making around sedation titration and also for documentation of the care provided. Natural language processing could be applied to real-time transcriptions of audio recordings made during procedures in order to classify sedation states that involve movement and pain, which could then be integrated into clinical documentation systems...
March 26, 2024: Journal of Nursing Scholarship
https://read.qxmd.com/read/38532438/evaluation-of-a-new-concept-to-improve-and-organize-clinical-practice-in-nursing-education-a-pilot-study
#10
JOURNAL ARTICLE
Helle Skou Thomsen, Britt Egeris Jørgensen, Jette Kynde Schøtz, Line Muff Bech, Lea Ladegaard Grønkjær
BACKGROUND: Nursing students may experience clinical practice as unsafe due to the interactions with patients, fear of making mistakes, lack of clinical experience and supervision, which results in anxiety and stress. Thus, interventions to improve and organize the learning environment in clinical practice for nursing students are warranted, and the aim of this pilot-study was to evaluate a new concept of clinical practice in order to get insight on the different initiatives and gain knowledge for further developing...
March 26, 2024: BMC Nursing
https://read.qxmd.com/read/38531589/impact-of-clinical-supervision-on-the-mental-health-nursing-workforce-a-scoping-review-protocol
#11
JOURNAL ARTICLE
Joshua Henry McDonough, Kate Rhodes, Nicholas Procter
INTRODUCTION: Mental health nurses work in potentially unpredictable, stressful and complex environments that can lead to burn-out and high staff turnover. Clinical supervision is a formal and professional agreement between two or more people that aims to strengthen individuals' competencies and organisational strengths. Effective clinical supervision has been noted as a method of reducing workplace issues within mental health nursing, but there is not currently a synthesis of evidence in this area...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531216/-i-m-just-searching-to-get-better-constructions-of-treatment-citizenship-on-injectable-opioid-agonist-treatment
#12
JOURNAL ARTICLE
Samara Mayer, Emily Jenkins, Nadia Fairbairn, Al Fowler, Ryan McNeil
BACKGROUND: As part of the response to Canada's worsening overdose crisis driven by a toxic, adulterated drug supply, there has been increased attention to and expansion of drug treatment, options, including injectable opioid agonist treatment (iOAT). iOAT typically involves the, witnessed daily injection of opioids under healthcare provider supervision. There is a robust, evidence base on iOAT; however, there has been less focus on how people engage with this; treatment outside of clinical trials...
March 20, 2024: Social Science & Medicine
https://read.qxmd.com/read/38530827/use-of-a-health-worker-targeted-smartphone-app-to-support-quality-malaria-rdt-implementation-in-busia-county-kenya-a-feasibility-and-acceptability-study
#13
JOURNAL ARTICLE
Malia Skjefte, Shawna Cooper, Stephen Poyer, Christopher Lourenço, Sam Smedinghoff, Brett Keller, Tonny Wambua, Christine Oduor, Sasha Frade, Wycliffe Waweru
Malaria rapid diagnostic tests (mRDTs) are an essential diagnostic tool in low-resource settings; however, administration and interpretation errors reduce their effectiveness. HealthPulse, a smartphone mRDT reader application, was developed by Audere to aid health workers in mRDT administration and interpretation, with an aim to improve the mRDT testing process and facilitate timely decision making through access to digitized results. Audere partnered with PSI and PS Kenya to conduct a pilot study in Busia County, Kenya between March and September 2021 to assess the feasibility and acceptability of HealthPulse to support malaria parasitological diagnosis by community health volunteers (CHVs) and private clinic health workers (private clinic HWs)...
2024: PloS One
https://read.qxmd.com/read/38530230/group-based-exercise-training-programs-for-military-members-presenting-musculoskeletal-disorders-a-pragmatic-randomized-controlled-trial
#14
JOURNAL ARTICLE
Frédérique Dupuis, Kadija Perreault, Luc J Hébert, Marc Perron, Anny Fredette, François Desmeules, Jean-Sébastien Roy
OBJECTIVE: To compare the effects of personalized supervised group-based programs (group physical therapy programs) to usual one-on-one physical therapy care (usual physical therapy care) on disability for military personnel suffering from low back pain, rotator cuff-related shoulder pain, patellofemoral pain syndrome or lateral ankle sprain. Secondary outcomes were pain severity, pain-related fear, health-related quality of life and patients' satisfaction with their condition and care. DESIGN: Non-inferiority pragmatic randomized clinical trial...
March 26, 2024: Journal of Orthopaedic and Sports Physical Therapy
https://read.qxmd.com/read/38529183/unlocking-the-potential-of-fondaparinux-guideline-for-optimal-usage-and-clinical-suggestions-2023
#15
REVIEW
Qinan Yin, Lizhu Han, Yin Wang, Fengjiao Kang, Fengqun Cai, Liuyun Wu, Xingyue Zheng, Lian Li, Li E Dong, Limei Dong, Shuhong Liang, Min Chen, Yong Yang, Yuan Bian
Background: Thromboembolic disease is associated with a high rate of disability or death and gravely jeopardizes people's health and places considerable financial pressure on society. The primary treatment for thromboembolic illness is anticoagulant medication. Fondaparinux, a parenteral anticoagulant medicine, is still used but is confusing due to its disparate domestic and international indications and lack of knowledge about its usage. Its off-label drug usage in therapeutic settings and irrational drug use are also common...
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38529071/global-is-local-leveraging-global-mental-health-methods-to-promote-equity-and-address-disparities-in-the-united-states
#16
JOURNAL ARTICLE
Ali Giusto, Helen E Jack, Jessica F Magidson, David Ayuku, Savannah Johnson, Kathryn Lovero, Sidney H Hankerson, Annika C Sweetland, Bronwyn Myers, Palmira Fortunato Dos Santos, Eve S Puffer, Milton L Wainberg
Structural barriers perpetuate mental health disparities for minoritized US populations; global mental health (GMH) takes an interdisciplinary approach to increasing mental health care access and relevance. Mutual capacity building partnerships between low and middle-income countries and high-income countries are beginning to use GMH strategies to address disparities across contexts. We highlight these partnerships and shared GMH strategies through a case series of said partnerships between Kenya-North Carolina, South Africa-Maryland, and Mozambique-New York...
March 2024: Clinical Psychological Science
https://read.qxmd.com/read/38528509/clinical-analysis-of-acute-poisoning-in-children
#17
JOURNAL ARTICLE
Huajun Zhang, Qin Huo, Rui Jing, Meng Dong
OBJECTIVE: The clinical characteristics of hospitalized children with acute poisoning were analyzed to provide a reference for preventing poisoning and seeking effective prevention and treatment. METHODS: The clinical data of 112 children with acute poisoning admitted to Qilu Hospital of Shandong University from January 1, 2018, to December 31, 2021, were collected and analyzed from different perspectives. RESULTS: The majority of acute poisoning cases that occurred in children were in early childhood and preschool age (89 cases, accounting for 79...
March 25, 2024: BMC Pediatrics
https://read.qxmd.com/read/38527027/mechanisms-of-near-peer-learning-in-a-longitudinal-clerkship-a-grounded-theory-study
#18
JOURNAL ARTICLE
Lauren E Smith, Mary E McBride, Bruce Henschen, Jennifer Bierman, Toshiko Uchida, Walter Eppich
PURPOSE: Many medical schools incorporate longitudinal clerkships, which promote continuity and may offer early clinical exposure during the preclinical curriculum. However, the mechanisms of near-peer learning and how it contributes to the development of clinical skills in longitudinal clinical experiences are less clear. The authors explored how peer-to-peer interactions among medical students influenced their developmental trajectories from nascent clinicians to more seasoned practitioners capable of juggling dual roles of clinical care and clinical supervision within longitudinal clerkships...
March 25, 2024: Academic Medicine
https://read.qxmd.com/read/38526881/msmtseg-multi-stained-multi-tissue-segmentation-of-kidney-histology-images-via-generative-self-supervised-meta-learning-framework
#19
JOURNAL ARTICLE
Xueyu Liu, Rui Wang, Yexin Lai, Yongfei Wu, Hangbei Cheng, Yuanyue Lu, Jianan Zhang, Ning Hao, Chenglong Ban, Yanru Wang, Shuqin Tang, Yuxuan Yang, Ming Li, Xiaoshuang Zhou, Wen Zheng
Accurately diagnosing chronic kidney disease requires pathologists to assess the structure of multiple tissues under different stains, a process that is timeconsuming and labor-intensive. Current AI-based methods for automatic structure assessment, like segmentation, often demand extensive manual annotation and focus on single stain domain. To address these challenges, we introduce MSMTSeg, a generative self-supervised meta-learning framework for multi-stained multi-tissue segmentation in renal biopsy whole slide images (WSIs)...
March 25, 2024: IEEE Journal of Biomedical and Health Informatics
https://read.qxmd.com/read/38526539/personalized-ai-driven-real-time-models-to-predict-stress-induced-blood-pressure-spikes-using-wearable-devices-proposal-for-a-prospective-cohort-study
#20
JOURNAL ARTICLE
Ali Kargarandehkordi, Christopher Slade, Peter Washington
BACKGROUND: Referred to as the "silent killer," elevated blood pressure (BP) often goes unnoticed due to the absence of apparent symptoms, resulting in cumulative harm over time. Chronic stress has been consistently linked to increased BP. Prior studies have found that elevated BP often arises due to a stressful lifestyle, although the effect of exact stressors varies drastically between individuals. The heterogeneous nature of both the stress and BP response to a multitude of lifestyle decisions can make it difficult if not impossible to pinpoint the most deleterious behaviors using the traditional mechanism of clinical interviews...
March 25, 2024: JMIR Research Protocols
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