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Vitamin deficiencies

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https://www.readbyqxmd.com/read/29453514/prevalence-and-determinants-of-vitamin-d-deficiency-among-the-overweight-and-obese-singaporeans-seeking-weight-management-including-bariatric-surgery-a-relationship-with-bone-health
#1
Marc Weijie Ong, Chun Hai Tan, Anton Kui Sing Cheng
PURPOSE: Low vitamin D status is prevalent worldwide and has been linked to a variety of pathologies including obesity in adults. The severity of vitamin D deficiency amongst the overweight and obese Singaporeans is not well documented. The purpose of this prospective observational study was to assess the prevalence and determinants of vitamin D deficiency in a multi-ethnic Asian population referred for weight management, including those seeking bariatric surgery. MATERIALS AND METHODS: This was a cross-sectional study conducted among 111 consecutive subjects referred to a single institution weight management service in Singapore...
February 16, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29453341/transcriptomics-reveals-a-cross-modulatory-effect-between-riboflavin-and-iron-and-outlines-responses-to-riboflavin-biosynthesis-and-uptake-in-vibrio-cholerae
#2
Ignacio Sepúlveda-Cisternas, Luis Lozano Aguirre, Andrés Fuentes Flores, Ignacio Vásquez Solis de Ovando, Víctor Antonio García-Angulo
Vibrio cholerae, a pandemic diarrheagenic bacterium, is able to synthesize the essential vitamin riboflavin through the riboflavin biosynthetic pathway (RBP) and also to internalize it through the RibN importer. In bacteria, the way riboflavin biosynthesis and uptake functions correlate is unclear. To gain insights into the role of the riboflavin provision pathways in the physiology of V. cholerae, we analyzed the transcriptomics response to extracellular riboflavin and to deletions of ribD (RBP-deficient strain) or ribN...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453250/retinal-chitosan-conjugates-effectively-deliver-active-chromophores-to-retinal-photoreceptor-cells-in-blind-mice-and-dogs
#3
Songqi Gao, Shirin Kahremany, Jianye Zhang, Beata Jastrzebska, Janice Querubin, Simon M Petersen-Jones, Krzysztof Palczewski
The retinoid (visual) cycle consists of a series of biochemical reactions needed to regenerate the visual chromophore, 11-cis-retinal and sustain vision. Genetic or environmental factors affecting chromophore production can lead to blindness. Using animal models that mimic human retinal diseases, we previously demonstrated that mechanism-based pharmacological interventions can maintain vision in otherwise incurable genetic diseases of the retina. Here, we report that after 9-cis-retinal administration to lecithin:retinol acyltransferase-deficient (Lrat-/-) mice, the drug was rapidly absorbed and then cleared within 1-2 h...
February 16, 2018: Molecular Pharmacology
https://www.readbyqxmd.com/read/29451635/-serum-25-hydroxyvitamin-d-state-in-healthy-children-ten-year-minors-old-of-barranquilla-metropolitan-area
#4
Belle Marie Acosta-Bendek, Lucía Patricia Sánchez-Majana, Jennifer Fonseca-Galé, Rocío Posada-Valencia, Mylene Rodríguez-Leyton, Luz Adriana Sarmiento-Rubiano
OBJETIVE: To evaluate the serum 25-hydroxyvitamin D (25-OH-D) levels in healthy children under 10 years of the Barranquilla metropolitan area. MATERIALS AND METHODS: A descriptive cross-sectional study in which serum levels of 25-OH-D were analyzed in 360 healthy children from 2014 to 2015. RESULTS: The median value of 25-OH-D serum level was 32.23±8.56 ng/mL; 46.38% of children had vitamin D levels in the insufficient range (<30 ng/mL), while 3...
November 2017: Salud Pública de México
https://www.readbyqxmd.com/read/29451618/the-association-of-vitamin-d-levels-and-the-frailty-phenotype-among-non-geriatric-dialysis-patients-a-cross-sectional-study
#5
Demet Tekdos Demircioglu
OBJECTIVES: The aim of this study was to investigate the frequency of frailty and the association of vitamin D levels and the frailty phenotype among non-geriatric dialysis patients. METHOD: Seventy-four stable, chronic hemodialysis patients from the hemodialysis unit of the hospital were enrolled in the study. The patients' medical histories and laboratory findings were obtained from the medical records of the dialysis unit. Serum parathyroid hormone and 25-hydroxy vitamin D levels were determined using chemiluminometric immunoassays...
2018: Clinics
https://www.readbyqxmd.com/read/29450585/effect-of-isolated-vitamin-d-supplementation-on-bone-turnover-markers-in-younger-postmenopausal-women-a-randomized-double-blind-placebo-controlled-trial
#6
J Nahas-Neto, L M Cangussu, C L Orsatti, F N Bueloni-Dias, P F Poloni, E B Schmitt, E A P Nahas
Vitamin D (VD) plays an important role in bone mineralization. The present study investigates the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women. It has been shown that VD supplementation in postmenopausal women with hypovitaminosis D is associated with a reduction in bone turnover markers. PURPOSE: The purpose of this study is to evaluate the effect of VD supplementation alone on bone turnover markers in younger postmenopausal women. METHODS: In this double-blind, placebo-controlled trial, 160 women were randomized into the VD group (supplementation with 1000 IU of vitamin D3/day, orally; n = 80) or placebo group (n = 80)...
February 15, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29449829/effects-of-vitamin-d-deficiency-on-incidence-risk-of-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis
#7
Mansour Amraei, Safoura Mohamadpour, Kourosh Sayehmiri, Seyedeh Fatemeh Mousavi, Ehsan Shirzadpour, Ardeshir Moayeri
Introduction: Proper nutrition is important for overall health, and it reduces healthcare costs associated with malnutrition. Many studies have investigated vitamin D deficiency and its role in gestational diabetes and controversial data have reported. A comprehensive consideration of articles in this field provides the possibility of a general study of this relationship. This meta-analysis is an evaluation of the relationship between vitamin D deficiency and gestational diabetes. Material and methods: Different databases (such as PubMed, Science Information Institute, EmBase, Scopus, and the Cochrane Library) were searched for studies and eligible English articles published before February 2017 that have reported the risk of gestational diabetes in relation to vitamin D deficiency...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29449314/vitamin-d-pcos-and-androgens-in-men-a-systematic-review
#8
Christian Trummer, Stefan Pilz, Verena Schwetz, Barbara R Obermayer-Pietsch, Elisabeth Lerchbaum
BACKGROUND: Accumulating evidence from animal and human studies suggests that vitamin D is involved in many functions of the reproductive system in both genders. AIM: The aim of this review was to provide an overview on the effects of vitamin D on polycystic ovary syndrome (PCOS) in women and androgen metabolism in men. METHODS: We performed a systematic literature search in Pubmed for relevant English language publications published from January 2012 until July 2017...
February 15, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29447824/central-xanthoma-of-the-mandible-associated-with-hyperlipidemia-a-rare-presentation
#9
John K Brooks, Behzad Mostoufi, Ahmed S Sultan, Zaid H Khoury, Jeffery B Price, John C Papadimitriou, John R Basile, Cinthia B Drachenberg, Rania H Younis
Xanthoma is a common, self-limiting cutaneous lesion of non-Langerhans cell, lipid-laden foamy histiocytes that is often concomitant with hyperlipidemia. The intraosseous counterpart is rarely encountered and typically presents as a painless, expansile osteolytic process in the context of hyperlipidemia or normolipidemia. Only a scant number of gnathic xanthomas have been reported in the otolaryngologic literature. We report the clinical, laboratory, radiographic, histopathologic, immunohistochemical, and ultrastructural studies of a mandibular lesion discovered in an asymptomatic 16-year-old male, and associated with 2 previously unreported comorbidities, namely hyperlipidemia and vitamin D deficiency...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447793/clinical-role-of-vitamin-d-in-prognosis-of-otitis-media-with-effusion
#10
Fatih Alper Akcan, Yusuf Dündar, Hümeyra Bayram Akcan, Ahmet Uluat, Derya Cebeci, Mehmet Ali Sungur, İlhan Ünlü
OBJECTIVE: To investigate the clinical role of Vitamin D in prognosis of Otitis media with effusion. METHODS: This prospective-controlled study was conducted at otolaryngology department in Duzce University, Turkey. The study group comprised children who were diagnosed with Otitis media with effusion between September 2016 and February 2017. Control group was conducted with children underwent circumcision or inguinal hernia repair operations that confirmed with ENT examination they do not have any sign of otitis media...
February 2018: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/29447493/vitamin-d-and-ferritin-correlation-with-chronic-neck-pain-using-standard-statistics-and-a-novel-artificial-neural-network-prediction-model
#11
Haytham Eloqayli, Ali Al-Yousef, Raid Jaradat
AIM: Despite the high prevalence of chronic neck pain, there is limited consensus about the primary etiology, risk factors, diagnostic criteria and therapeutic outcome. Here, we aimed to determine if Ferritin and Vitamin D are modifiable risk factors with chronic neck pain using slandered statistics and artificial intelligence neural network (ANN). METHODS: Fifty-four patients with chronic neck pain treated between February 2016 and August 2016 in King Abdullah University Hospital and 54 patients age matched controls undergoing outpatient or minor procedures were enrolled...
February 15, 2018: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/29447473/impact-of-micronutrients-on-the-immune-response-of-animals
#12
Allen D Smith, Kiran S Panickar, Joseph F Urban, Harry D Dawson
Vitamins and minerals (micronutrients) play an important role in regulating and shaping an immune response. Deficiencies generally result in inadequate or dysregulated cellular activity and cytokine expression, thereby affecting the immune response. Decreased levels of natural killer, granulocyte, and phagocytic cell activity and T and B cell proliferation and trafficking are associated with inadequate levels of micronutrients, as well as increased susceptibility to various adverse health conditions, including inflammatory disorders, infection, and altered vaccine efficacy...
February 15, 2018: Annual Review of Animal Biosciences
https://www.readbyqxmd.com/read/29447107/vitamin-d-status-and-risk-of-dementia-and-alzheimer-s-disease-a-meta-analysis-of-dose-response
#13
Ahmad Jayedi, Ali Rashidy-Pour, Sakineh Shab-Bidar
OBJECTIVE: We aimed to test the dose-response association of serum 25(OH)D and risk of dementia and Alzheimer's disease (AD). METHODS: We performed a systematic search of PubMed and Scopus from database inception up to September 2017. Longitudinal cohort studies reporting risk estimates of incident dementia or AD in the general population, and for three or more quantitative categories of serum 25(OH)D were included. Pooled hazard ratios (HRs) were calculated using fixed-effects/random-effects models...
February 15, 2018: Nutritional Neuroscience
https://www.readbyqxmd.com/read/29447022/correction-to-seyyed-abootorabi-et-al-the-effect-of-vitamin-d-supplementation-on-insulin-resistance-visceral-fat-and-adiponectin-in-vitamin-d-deficient-women-with-polycystic-ovary-syndrome-a-randomized-placebo-controlled-trial
#14
https://www.readbyqxmd.com/read/29447006/retinoic-acid-signaling-promotes-the-cytoskeletal-rearrangement-of-embryonic-epicardial-cells
#15
Suya Wang, Jianshi Yu, Jace W Jones, Keely Pierzchalski, Maureen A Kane, Paul A Trainor, José Xavier-Neto, Alexander R Moise
All- trans-retinoic acid (RA), a vitamin A metabolite, is an important signaling molecule required for the proper development of the heart. The epicardium is the main source of RA in the embryonic heart, yet the cardiogenic functions of epicardial-produced RA are not fully understood. Here, we investigated the roles of RA signaling in the embryonic epicardium using in vivo and in vitro models of excess or deficiency of RA. Our results suggested that RA signaling facilitates the cytoskeletal rearrangement required for the epicardial-to-mesenchymal transition of epicardial cells...
February 15, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29446340/identification-of-vitamin-b12-deficiency-in-vegetarian-indians
#16
Sadanand Naik, Namita Mahalle, Vijayshri Bhide
The prevalence of a sub-clinical vitamin B12 deficiency in the vegetarians is high. Total serum vitamin B12 concentration alone does not reliably reflect vitamin B12 status. Holotranscobalamin (holo-TC) II is a bioactive B12 fraction promoting specific uptake of B12 by cells and the circulating concentration reflects the intake of B12, whereas total homocysteine (tHcy) indicates the metabolic ability. In this study, we investigated the diagnostic value of circulating holo-TC, B12, folate and homocysteine in vegetarians who were at risk of B12 deficiency...
February 15, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29445644/the-prevalence-of-vitamin-d-deficiency-in-adults-in-kermanshah-western-iran
#17
Mazaher Ramezani, Masoud Sadeghi
No abstract text is available yet for this article.
February 2018: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29445423/an-update-on-vitamin-b12-related-gene-polymorphisms-and-b12-status
#18
REVIEW
S Surendran, A Adaikalakoteswari, P Saravanan, I A Shatwaan, J A Lovegrove, K S Vimaleswaran
Background: Vitamin B12 is an essential micronutrient in humans needed for health maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and genetic factors. Evidence for the genetic basis of vitamin B12 status is poorly understood. However, advancements in genomic techniques have increased the knowledge-base of the genetics of vitamin B12 status. Based on the candidate gene and genome-wide association (GWA) studies, associations between genetic loci in several genes involved in vitamin B12 metabolism have been identified...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29445220/association-of-admission-serum-levels-of-vitamin-d-calcium-phosphate-magnesium-and-parathormone-with-clinical-outcomes-in-neurosurgical-icu-patients
#19
Seyed Hossein Ardehali, Salman Dehghan, Ahmad Reza Baghestani, Aynaz Velayati, Zahra Vahdat Shariatpanahi
To evaluate the association of admission serum levels of 25(OH)D, parathormone and the related electrolytes with severity of illness and clinical outcomes in neurosurgical critically ill patients, serum levels of 25(OH)D, parathormone, calcium, magnesium, and phosphate, along with APACHE II score were measured for 210 patients upon admission. Mean serum 25(OH)D was 21.1 ± 7.4 ng/mL. 25(OH)D deficiency (less than 20 ng/dL) and elevated serum parathormone level were found in 47.6% and 38% of patients respectively...
February 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29445184/parental-micronutrient-deficiency-distorts-liver-dna-methylation-and-expression-of-lipid-genes-associated-with-a-fatty-liver-like-phenotype-in-offspring
#20
Kaja H Skjærven, Lars Martin Jakt, Jorge M O Fernandes, John Arne Dahl, Anne-Catrin Adam, Johanna Klughammer, Christoph Bock, Marit Espe
Micronutrient status of parents can affect long term health of their progeny. Around 2 billion humans are affected by chronic micronutrient deficiency. In this study we use zebrafish as a model system to examine morphological, molecular and epigenetic changes in mature offspring of parents that experienced a one-carbon (1-C) micronutrient deficiency. Zebrafish were fed a diet sufficient, or marginally deficient in 1-C nutrients (folate, vitamin B12, vitamin B6, methionine, choline), and then mated. Offspring livers underwent histological examination, RNA sequencing and genome-wide DNA methylation analysis...
February 14, 2018: Scientific Reports
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