keyword
https://read.qxmd.com/read/36539322/end-to-end-testing-for-stereotactic-radiotherapy-including-the-development-of-a-multi-modality-phantom
#21
JOURNAL ARTICLE
Maya Shariff, Johanna Grigo, Siti Masitho, Tobias Brandt, Alexander Weiss, Ulrike Lambrecht, Willi Stillkrieg, Michael Lotter, Florian Putz, Rainer Fietkau, Christoph Bert
PURPOSE: A new insert for a commercially available end-to-end test phantom was designed and in-house manufactured by 3D printing. Subsequently, the insert was tested for different stereotactic radiation therapy workflows (SRS, SBRT, FSRT, and Multimet) also in comparison to the original insert. MATERIAL AND METHODS: Workflows contained imaging (MR, CT), treatment planning, positioning, and irradiation. Positioning accuracy was evaluated for non-coplanar x-ray, kV- and MV-CBCT systems, as well as surface guided radiation therapy...
December 18, 2022: Zeitschrift Für Medizinische Physik
https://read.qxmd.com/read/36472802/clinical-validation-of-the-varian-truebeam-intra-fraction-motion-review-imr-system-for-prostate-treatment-guidance
#22
JOURNAL ARTICLE
Guneet Kaur, Joerg Lehmann, Peter B Greer, Jarad Martin, John Simpson
This study quantified the performance of Intra-fraction Motion Review (IMR) during prostate Stereotactic Body Radiotherapy (SBRT) treatments. IMR was evaluated using prostate motion data from patients treated in an SBRT clinical trial (PROMETHEUS, NCT00587990).IMR measured prostate displacements were compared to those of two 3D motion management methods: Kilovoltage Intra-fraction Motion management (KIM) and MV/kV triangulation. A planning study assessing the impact of a defined prostate motion (2-5 mm) on the PTV  coverage with and without IMR was performed...
December 6, 2022: Physical and engineering sciences in medicine
https://read.qxmd.com/read/36300870/treatment-planning-with-a-2-5-mv-photon-beam-for-radiation-therapy
#23
JOURNAL ARTICLE
Navid Khaledi, Chris Hayes, Louise Belshaw, Mark Grattan, Rao Khan, James L Gräfe
PURPOSE: The shallow depth of maximum dose and higher dose fall-off gradient of a 2.5 MV beam along the central axis that is available for imaging on linear accelerators is investigated for treatment of shallow tumors and sparing the organs at risk (OARs) beyond it. In addition, the 2.5 MV beam has an energy bridging the gap between kilo-voltage (kV) and mega-voltage (MV) beams for applications of dose enhancement with high atomic number (Z) nanoparticles. METHODS: We have commissioned and utilized a MATLAB-based, open-source treatment planning software (TPS), matRad, for intensity-modulated radiation therapy (IMRT) dose calculations...
October 27, 2022: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/36297640/quantifying-radiosensitization-of-psma-targeted-gold-nanoparticles-on-prostate-cancer-cells-at-megavoltage-radiation-energies-by-monte-carlo-simulation-and-local-effect-model
#24
JOURNAL ARTICLE
Ryder M Schmidt, Daiki Hara, Jorge D Vega, Marwan B Abuhaija, Wensi Tao, Nesrin Dogan, Alan Pollack, John C Ford, Junwei Shi
Active targeting gold nanoparticles (AuNPs) are a very promising avenue for cancer treatment with many publications on AuNP mediated radiosensitization at kilovoltage (kV) photon energies. However, uncertainty on the effectiveness of AuNPs under clinically relevant megavoltage (MV) radiation energies hinders the clinical translation of AuNP-assisted radiation therapy (RT) paradigm. The aim of this study was to investigate radiosensitization mediated by PSMA-targeted AuNPs irradiated by a 6 MV radiation beam at different depths to explore feasibility of AuNP-assisted prostate cancer RT under clinically relevant conditions...
October 17, 2022: Pharmaceutics
https://read.qxmd.com/read/36155488/evaluation-of-the-voluntary-deep-inspiration-breath-hold-reproducibility-in-left-sided-breast-radiotherapy
#25
JOURNAL ARTICLE
Ferihan Ertan, Serdar Sahin, Can Azak, Ebru Karakaya, Muzaffer Bedri Altundag, Fatih Goksel
PURPOSE: Voluntary deep inspiration breath hold (v-DIBH) reduces cardiac dose during left-sided breast irradiation. The purpose of this study is to evaluate the reproducibility and variability of breath-hold level (BHL) using breath-hold curves and lateral kV setup images together. MATERIAL/METHOD: A retrospective analysis of 30 left breast cancer patients treated using the v-DIBH technique in our department is performed. The BHL difference is measured from breath hold curves and lateral (LAT) kilo-Voltage (kV) setup images...
September 23, 2022: Journal of X-ray Science and Technology
https://read.qxmd.com/read/36118989/clinical-implementation-of-the-first-cherenkov-imaging-system-in-a-community-based-hospital
#26
JOURNAL ARTICLE
Erli Chen, Brian W Pogue, Petr Bruza, Daniel A Alexander, Nancy L Andino, Savannah M Decker, Danielle M Gaudet, David J Gladstone, Melinda J Lake, Steven R Levene, Jennifer L Michelson, Hila L Robinson, Debra N Stallings, John E Starkey, Lesley A Jarvis
Purpose: To document experiences with one year of clinical implementation of the first Cherenkov imaging system and share the methods that we developed to utilize Cherenkov imaging to improve treatment delivery accuracy in real-time. Methods: A Cherenkov imaging system was installed commissioned and calibrated for clinical use. The optimal room lighting conditions and imaging setup protocols were developed to optimize both image quality and patient experience. The Cherenkov images were analyzed for treatment setup and beam delivery verification...
December 2022: Technical innovations & patient support in radiation oncology
https://read.qxmd.com/read/36084626/accuracy-and-potential-improvements-of-surface-guided-breast-cancer-radiotherapy-in-deep-inspiration-breath-hold-with-daily-image-guidance
#27
JOURNAL ARTICLE
Saber Nankali, Rune Hansen, Esben S Worm, Esben Svitzer Yates, Mette Skovhus Thomsen, Birgitte Offersen, Per Rugaard Poulsen
Objective Radiotherapy of left-sided breast cancer in deep inspiration breath-hold (DIBH) reduces the heart dose. Surface guided radiotherapy (SGRT) can guide the DIBH, but the accuracy is subject to variations in the chest wall position relative to the patient surface. Approach In this study, ten left-sided breast cancer patients received DIBH radiotherapy with tangential fields in 15-18 fractions. After initial SGRT setup in free breathing an orthogonal MV/kV image pair was acquired during SGRT-guided breath-hold...
September 9, 2022: Physics in Medicine and Biology
https://read.qxmd.com/read/36004606/energy-dependence-investigation-for-a-range-of-clinically-used-detectors-from-70kv-6mv
#28
JOURNAL ARTICLE
Laura Shields, Mihails Nikandrovs, Luis León Vintró, Brendan Mc Clean
PURPOSE: Accurate measurement of out-of-field dose in radiotherapy directly impacts beam data modelling in treatment planning systems, verification of implanted electronic devices/lens/foetus dose, secondary cancer risk estimation and organ at risk dose reporting. When performing out-of-field dosimetry it is therefore imperative that the response of the detector has been well characterised. Due to the softening of the radiation beam out of field many detectors will exhibit energy dependence...
August 25, 2022: Medical Physics
https://read.qxmd.com/read/35938467/a-novel-multichannel-deep-learning-model-for-fast-denoising-of-monte-carlo-dose-calculations-preclinical-applications
#29
JOURNAL ARTICLE
Robert H W van Dijk, Nick Staut, Cecile J A Wolfs, Frank Verhaegen
Objective. In preclinical radiotherapy with kilovolt (kV) x-ray beams, accurate treatment planning is needed to improve the translation potential to clinical trials. Monte Carlo based radiation transport simulations are the gold standard to calculate the absorbed dose distribution in external beam radiotherapy. However, these simulations are notorious for their long computation time, causing a bottleneck in the workflow. Previous studies have used deep learning models to speed up these simulations for clinical megavolt (MV) beams...
August 8, 2022: Physics in Medicine and Biology
https://read.qxmd.com/read/35853441/concurrent-kilovoltage-cbct-imaging-and-megavoltage-beam-delivery-suppression-of-cross-scatter-with-2d-antiscatter-grids-and-grid-based-scatter-sampling
#30
JOURNAL ARTICLE
Farhang Bayat, Mohamed Elsayed Eldib, Brian Kavanagh, Moyed Miften, Cem Altunbas
Objective . The concept of using kilovoltage (kV) and megavoltage (MV) beams concurrently has potential applications in cone beam computed tomography (CBCT) guided radiation therapy, such as single breath hold scans, metal artifact reduction, and simultaneous imaging during MV treatment delivery. However, MV cross-scatter generated during MV beam delivery degrades CBCT image quality. To address this, a 2D antiscatter grid and a cross-scatter correction method were investigated in the context of high dose MV treatment delivery...
August 9, 2022: Physics in Medicine and Biology
https://read.qxmd.com/read/35668122/catalytic-activity-imperative-for-nanoparticle-dose-enhancement-in-photon-and-proton-therapy
#31
JOURNAL ARTICLE
Lukas R H Gerken, Alexander Gogos, Fabian H L Starsich, Helena David, Maren E Gerdes, Hans Schiefer, Serena Psoroulas, David Meer, Ludwig Plasswilm, Damien C Weber, Inge K Herrmann
Nanoparticle-based radioenhancement is a promising strategy for extending the therapeutic ratio of radiotherapy. While (pre)clinical results are encouraging, sound mechanistic understanding of nanoparticle radioenhancement, especially the effects of nanomaterial selection and irradiation conditions, has yet to be achieved. Here, we investigate the radioenhancement mechanisms of selected metal oxide nanomaterials (including SiO2 , TiO2 , WO3 and HfO2 ), TiN and Au nanoparticles for radiotherapy utilizing photons (150 kVp and 6 MV) and 100 MeV protons...
June 6, 2022: Nature Communications
https://read.qxmd.com/read/35570390/characterization-of-imaging-performance-of-a-novel-helical-kvct-for-use-in-image-guided-and-adaptive-radiotherapy
#32
JOURNAL ARTICLE
Riley C Tegtmeier, William S Ferris, John E Bayouth, Jessica R Miller, Wesley S Culberson
ClearRT helical kVCT imaging for the Radixact helical tomotherapy system recently received FDA approval and is available for clinical use. The system is intended to enhance image fidelity in radiation therapy treatment planning and delivery compared to the prior MV-based onboard imaging approach. The purpose of this work was to characterize the imaging performance of this system and compare this performance with that of clinical systems used in image-guided and/or adaptive radiotherapy (ART) or computed tomography (CT) simulation, including Radixact MVCT, TomoTherapy MVCT, Varian TrueBeam kV OBI CBCT, and the Siemens SOMATOM Definition Edge kVCT...
June 2022: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/35465130/megavoltage-cross-scatter-rejection-and-correction-using-2d-antiscatter-grids-in-kilovoltage-cbct-imaging
#33
JOURNAL ARTICLE
Farhang Bayat, Mohamed Elsayed Eldib, Cem Altunbas
Simultaneous use of kilovoltage (kV) and megavoltage (MV) beams has numerous potential applications in cone beam computed tomography (CBCT)-guided radiotherapy, such as fast MV+kV CBCT for single breath-hold scan, tumor localization with kV CBCT imaging during MV therapy delivery, and metal artifact suppression. However, the introduction of MV beams results in a large MV-cross scatter fluence incident on the kV Flat Panel Detector (FPD), and thus, deteriorating the low contrast visualization and Hounsfield Unit (HU) accuracy...
2022: Proceedings of SPIE
https://read.qxmd.com/read/35338574/retrospective-analysis-of-mv-kv-imaging-based-fiducial-tracking-in-prostate-sbrt-treatment
#34
JOURNAL ARTICLE
Kevin Crotteau, Wei Lu, Sean Berry, Laura Happersett, Sarah Burleson, Weixing Cai
PURPOSE: Motion management is critical for prostate stereotactic body radiotherapy (SBRT) due to its high fractional dose and proximity to organs at risk. This study seeks to quantify the advantages of MV-kV tracking over kV imaging alone through a retrospective analysis of over 300 patients who underwent prostate SBRT treatment using MV-kV tracking. METHODS: An MV-kV imaging-based fiducial tracking technique has been developed at our institute and become a standard clinical practice...
June 2022: Journal of Applied Clinical Medical Physics
https://read.qxmd.com/read/35100573/an-investigation-of-kv-mini-grid-spatially-fractionated-radiation-therapy-dosimetry-and-preclinical-trial
#35
JOURNAL ARTICLE
Timothy R Johnson, Alex M Bassil, Nerissa T Williams, Simon Brundage, Collin L Kent, Greg Palmer, Yvonne M Mowery, Mark Oldham
Objective . To develop and characterize novel methods of extreme spatially fractionated kV radiation therapy (including mini-GRID therapy) and to evaluate efficacy in the context of a pre-clinical mouse study. Approach . Spatially fractionated GRIDs were precision-milled from 3 mm thick lead sheets compatible with mounting on a 225 kVp small animal irradiator (X-Rad). Three pencil-beam GRIDs created arrays of 1 mm diameter beams, and three 'bar' GRIDs created 1 × 20 mm rectangular fields. GRIDs projected 20 × 20 mm2 fields at isocenter, and beamlets were spaced at 1, 1...
February 18, 2022: Physics in Medicine and Biology
https://read.qxmd.com/read/35098549/investigation-of-image-quality-of-mv-and-kv-cbct-with-low-z-beams-and-high-dqe-detector
#36
JOURNAL ARTICLE
Jericho O'Connell, Magdalena Bazalova-Carter
PURPOSE: To investigate cone beam computed tomography (CBCT) image quality using novel combinations of kilovoltage (kV) and megavoltage (MV) beams and detector materials. METHODS: MV and kV CBCT imaging was simulated using the Fastcat hybrid Monte Carlo application. CBCT imaging with various beam energies was investigated: 2.5 and 6 MV photon beams generated with carbon, aluminum, and tungsten targets and a 120 kVp x-ray tube beam based off of a Varian Truebeam on-board imager (OBI)...
April 2022: Medical Physics
https://read.qxmd.com/read/35036634/clinical-assessment-of-a-novel-ring-gantry-linear-accelerator-mounted-helical-fan-beam-kvct-system
#37
JOURNAL ARTICLE
Christian Velten, Lee Goddard, Kyoungkeun Jeong, Madhur K Garg, Wolfgang A Tomé
Purpose: To assess clinically relevant image quality metrics (IQMs) of helical fan beam kilovoltage (kV) fan beam computed tomography (CT). Methods and Materials: kVCT IQMs were evaluated on an Accuray Radixact unit equipped with helical fan beam kVCT to assess the capabilities of this newly available modality. kVCT IQMs were evaluated and compared to a kVCT simulator and linear accelerator-based cone beam CTs (CBCT) using a commercial CBCT image quality phantom...
March 2022: Advances in Radiation Oncology
https://read.qxmd.com/read/34844272/-treatment-planning-and-dose-verification-for-combined-internal-and-external-radiotherapy-ciert
#38
JOURNAL ARTICLE
Robert Freudenberg, Holger Hartmann, Michael Andreeff, Liane Oehme, Thomas Leichtner, Alexander Fischer, Timo Paulus, Mechthild Krause, Jörg Kotzerke
AIM: The combined internal and external radiotherapy (CIERT) take advantage of the benefits from radionuclide therapy and external beam irradiation. These include steep dose gradients and a low toxicity to normal tissue due to the use of unsealed radioisotopes as well as homogeneous dose distribution within the tumor due to external beam irradiation. For a combined irradiation planning, an infrastructure has to be developed that takes into account the dose contributions from both modalities...
February 2022: Nuklearmedizin. Nuclear Medicine
https://read.qxmd.com/read/34796527/a-customizable-anthropomorphic-phantom-for-dosimetric-verification-of-3d-printed-lung-tissue-and-bone-density-materials
#39
JOURNAL ARTICLE
Rance Bolislis Tino, Adam Unjin Yeo, Milan Brandt, Martin Leary, Tomas Kron
PURPOSE: To design and manufacture a customized thoracic phantom slab utilizing the 3D printing process, also known as additive manufacturing, consisting of different tissue density materials. Here, we demonstrate the 3D-printed phantom's clinical feasibility for imaging and dosimetric verification of volumetric modulated arc radiotherapy (VMAT) plans for lung and spine stereotactic ablative body radiotherapy (SABR) through end-to-end dosimetric verification. METHODS: A customizable anthropomorphic phantom slab was designed using the CT dataset of a commercial phantom (adult female ATOM dosimetry phantom, CIRS Inc...
January 2022: Medical Physics
https://read.qxmd.com/read/34778990/breast-radiotherapy-with-kilovoltage-photons-and-gold-nanoparticles-as-radiosensitizer-an-in-vitro-study-x-ray-breast-radiotherapy-with-aunp
#40
JOURNAL ARTICLE
Alessia Tudda, Elisabetta Donzelli, Gabriella Nicolini, Sara Semperboni, Mario Bossi, Guido Cavaletti, Roberta Castriconi, Paola Mangili, Antonella Del Vecchio, Antonio Sarno, Giovanni Mettivier, Paolo Russo
PURPOSE: We investigated the dose enhancement and internalization of gold nanoparticles (AuNP) used as a radiosensitizer agent for rotational radiotherapy of breast cancer using a kilovoltage X-ray beam. METHODS: Human breast cancer cells MDA-MB-231 were incubated with or without 100 μg/ml (4.87 nM) or 200 μg/ml (9.74 nM) 15 nm AuNPs and irradiated with 100 kV, 190 kV or 6 MV X-rays. To assess the toxicity of the AuNPs, we performed a Sulforhodamine B assay. Using atomic absorption spectroscopy, scanning electron microscopy, transmission electron microscopy, and time-lapse optical microscopy (rate of 2 frames per minute), we carried out a quantitative assessment of the amount of gold internalized by MDA-MB-231 cells and a characterization of the static and dynamical aspects of this internalization process...
November 14, 2021: Medical Physics
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