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https://www.readbyqxmd.com/read/28230781/-dose-to-mother-deuterium-oxide-dilution-technique-an-accurate-strategy-to-measure-vitamin-a-intake-in-breastfed-infants
#1
Veronica Lopez-Teros, Ana Teresa Limon-Miro, Humberto Astiazaran-Garcia, Sherry A Tanumihardjo, Orlando Tortoledo-Ortiz, Mauro E Valencia
In Mexico, infants (0-2 years old) show the highest prevalence of vitamin A deficiency (VAD), measured by serum retinol concentrations. Thus, we consider that low vitamin A (VA) intake through breast milk (BM) combined with poor weaning practices are the main factors that contribute to VAD in this group. We combined the assessment of VA status in lactating women using BM retinol and a stable isotope 'dose-to-mother' technique to measure BM production in women from urban and agricultural areas. Infants' mean BM intake was 758 ± 185 mL, and no difference was observed between both areas (p = 0...
February 21, 2017: Nutrients
https://www.readbyqxmd.com/read/28226936/electrosynthesis-of-magnetoresponsive-microrobot-for-targeted-drug-delivery-using-calcium-alginate
#2
Chengzhi Hu, Katharina Riederer, Michael Klemmer, Salvador Pane, Bradley J Nelson, Chengzhi Hu, Katharina Riederer, Michael Klemmer, Salvador Pane, Bradley J Nelson, Salvador Pane, Katharina Riederer, Bradley J Nelson, Michael Klemmer, Chengzhi Hu
Targeted drug delivery systems deliver drugs precisely to a specific targeted site inside the body, and can also release the drugs with controlled kinetics to prolong the efficacy of single dose administration. The advantageous properties of hydrogels make them attractive for use in the area of drug delivery. Calcium alginate is a pH sensitive hydrogel stable in acidic media and soluble in basic media. This enables the hydrogel to absorb and release aqueous solutions at certain ranges of pH values. By absorbing an aqueous solution containing a drug, an active drug release can be triggered at a specified range of pH value...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28225835/mulberry-extract-improves-glucose-tolerance-and-decreases-insulin-concentrations-in-normoglycaemic-adults-results-of-a-randomised-double-blind-placebo-controlled-study
#3
Mark Lown, Richard Fuller, Helen Lightowler, Ann Fraser, Andrew Gallagher, Beth Stuart, Christopher Byrne, George Lewith
BACKGROUND: High sugar and refined carbohydrate intake is associated with weight gain, increased incidence of diabetes and is linked with increased cardiovascular mortality. Reducing the health impact of poor quality carbohydrate intake is a public health priority. Reducose, a proprietary mulberry leaf extract (ME), may reduce blood glucose responses following dietary carbohydrate intake by reducing absorption of glucose from the gut. METHODS: A double-blind, randomised, repeat measure, phase 2 crossover design was used to study the glycaemic and insulinaemic response to one reference product and three test products at the Functional Food Centre, Oxford Brooks University, UK...
2017: PloS One
https://www.readbyqxmd.com/read/28223261/use-of-transabdominal-ultrasound-guided-transjugular-portal-vein-puncture-on-radiation-dose-in-transjugular-intrahepatic-portosystemic-shunt-formation
#4
Aniket N Tavare, Andrew Wigham, Anastasia Hadjivassilou, Abdulrahman Alvi, Anthie Papadopoulou, Antony Goode, Nick Woodward, David Patch, Dominic Yu, Neil Davies
PURPOSE: Transjugular intrahepatic portosystemic shunt (TIPS) creation is used to treat portal hypertension complications. Often the most challenging and time-consuming step in the procedure is the portal vein (PV) puncture. TIPS procedures are associated with prolonged fluoroscopy time and high patient radiation exposures. We measured the impact of transabdominal ultrasound guidance for PV puncture on duration of fluoroscopy time and dose. METHODS: We retrospectively analyzed the radiation dose for all TIPS performed over a four-year period with transabdominal ultrasound guidance for PV puncture (n=212, with 210 performed successfully and data available for 206); fluoroscopy time, dose area product (DAP) and skin dose were recorded...
February 22, 2017: Diagnostic and Interventional Radiology: Official Journal of the Turkish Society of Radiology
https://www.readbyqxmd.com/read/28221093/u-s-diagnostic-reference-levels-and-achievable-doses-for-10-adult-ct-examinations
#5
Kalpana M Kanal, Priscilla F Butler, Debapriya Sengupta, Mythreyi Bhargavan-Chatfield, Laura P Coombs, Richard L Morin
Purpose To develop diagnostic reference levels (DRLs) and achievable doses (ADs) for the 10 most common adult computed tomographic (CT) examinations in the United States as a function of patient size by using the CT Dose Index Registry. Materials and Methods Data from the 10 most commonly performed adult CT head, neck, and body examinations from 583 facilities were analyzed. For head examinations, the lateral thickness was used as an indicator of patient size; for neck and body examinations, water-equivalent diameter was used...
February 21, 2017: Radiology
https://www.readbyqxmd.com/read/28212299/exogenous-and-endogenous-hydrogen-sulfide-protects-gastric-mucosa-against-the-formation-and-time-dependent-development-of-ischemia-reperfusion-induced-acute-lesions-progressing-into-deeper-ulcerations
#6
Marcin Magierowski, Katarzyna Magierowska, Magdalena Hubalewska-Mazgaj, Zbigniew Sliwowski, Robert Pajdo, Grzegorz Ginter, Slawomir Kwiecien, Tomasz Brzozowski
Hydrogen sulfide (H₂S) is an endogenous mediator, synthesized from l-cysteine by cystathionine γ-lyase (CSE), cystathionine β-synthase (CBS) or 3-mercaptopyruvate sulfurtransferase (3-MST). The mechanism(s) involved in H₂S-gastroprotection against ischemia/reperfusion (I/R) lesions and their time-dependent progression into deeper gastric ulcerations have been little studied. We determined the effect of l-cysteine, H₂S-releasing NaHS or slow H₂S releasing compound GYY4137 on gastric blood flow (GBF) and gastric lesions induced by 30 min of I followed by 3, 6, 24 and 48 h of R...
February 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28210801/patient-radiation-doses-and-reference-levels-in-pediatric-interventional-radiology
#7
Bouchra Habib Geryes, Adeline Bak, Julie Lachaux, Augustin Ozanne, Nathalie Boddaert, Francis Brunelle, Olivier Naggara, Guillaume Saliou
OBJECTIVES: To describe, in a multicentric paediatric population, reference levels (RLs) for three interventional radiological procedures. METHODS: From January 2012 to March 2015, children scheduled for an interventional radiological procedure in two French tertiary centres were retrospectively included and divided into four groups according to age: children younger than 2 years (A1), aged 2-7 years (A5), 8-12 years (A10) and 13-18 years (A15). Three procedures were identified: cerebral digital subtraction angiography (DSA), brain arteriovenous malformation (bAVM) embolization, and head and neck superficial vascular malformation (SVM) percutaneous sclerotherapy...
February 16, 2017: European Radiology
https://www.readbyqxmd.com/read/28208806/orange-pomace-improves-postprandial-glycemic-responses-an-acute-randomized-placebo-controlled-double-blind-crossover-trial-in-overweight-men
#8
C-Y Oliver Chen, Helen Rasmussen, Alison Kamil, Peng Du, Jeffrey B Blumberg
Orange pomace (OP), a fiber-rich byproduct of juice production, has the potential for being formulated into a variety of food products. We hypothesized that OP would diminish postprandial glycemic responses to a high carbohydrate/fat breakfast and lunch. We conducted an acute, randomized, placebo-controlled, double blind, crossover trial with 34 overweight men who consumed either a 255 g placebo (PLA), a low (35% OP (LOP)), or a high (77% (HOP)) dose OP beverage with breakfast. Blood was collected at 0, 10, 20, 30, and 45 min and at 1, 1...
February 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28205150/the-potential-cost-effectiveness-of-different-dengue-vaccination-programmes-in-malaysia-a-value-based-pricing-assessment-using-dynamic-transmission-mathematical-modelling
#9
Asrul Akmal Shafie, Hui Yee Yeo, Laurent Coudeville, Lucas Steinberg, Balvinder Singh Gill, Rohani Jahis, Amar-Singh Hss
BACKGROUND: Dengue disease poses a great economic burden in Malaysia. METHODS: This study evaluated the cost effectiveness and impact of dengue vaccination in Malaysia from both provider and societal perspectives using a dynamic transmission mathematical model. The model incorporated sensitivity analyses, Malaysia-specific data, evidence from recent phase III studies and pooled efficacy and long-term safety data to refine the estimates from previous published studies...
February 15, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28204745/effective-dose-per-unit-kerma-area-product-conversion-factors-in-adults-undergoing-modified-barium-swallow-studies
#10
Heather Shaw Bonilha, Janina Wilmskoetter, Sameer V Tipnis, Bonnie Martin-Harris, Walter Huda
No abstract text is available yet for this article.
February 16, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28198573/radiation-dose-benchmarks-in-pediatric-cardiac-catheterization-a-prospective-multi-center-c3po-qi-study
#11
Priscila C Cevallos, Aimee K Armstrong, Andrew C Glatz, Bryan H Goldstein, Todd M Gudausky, Ryan A Leahy, Christopher J Petit, Shabana Shahanavaz, Sara M Trucco, Lisa J Bergersen
OBJECTIVES: This study sought to update benchmark values to use a quality measure prospectively. BACKGROUND: Congenital Cardiac Catheterization Outcomes Project - Quality Improvement (C3PO-QI), a multi-center registry, defined initial radiation dose benchmarks retrospectively across common interventional procedures. These data facilitated a dose metric endorsed by the American College of Cardiology in 2014. METHODS: Data was collected prospectively by 9 C3PO-QI institutions with complete case capture between 1/1/2014 and 6/30/2015...
February 15, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28196046/bioequivalence-of-a-new-oral-levosulpiride-formulation-compared-with-a-standard-one-in-healthy-volunteers
#12
Simona De Gregori, Laura Cipollina, Annalisa De Silvestri, Marianna Ventura, Roberta Michelini, Monica Morosini, Michela Montagna, Carmine Tinelli, Mario Regazzi, Mariadelfina Molinaro, Roberto Imberti
BACKGROUND: A monocentric, single-dose, open-label, two-way, crossover randomized study was conducted by the San Matteo Phase I Clinical Trial Unit and Experimental Therapy (Pavia, Italy) to assess the bioequivalence and the systemic tolerability of a new oral formulation of levosulpiride (tablet 25 mg: test) versus a commercially available formulation on the Italian market (tablet 25 mg: reference). METHODS: Thirty-five healthy adult volunteers, males (n = 19) and females (n = 16), aged between 18 and 55 years were screened and 32 of them were enrolled in the study...
February 11, 2017: Therapeutic Drug Monitoring
https://www.readbyqxmd.com/read/28193039/molecularly-imprinted-polymer-based-plasmonic-immunosandwich-assay-for-fast-and-ultrasensitive-determination-of-trace-glycoproteins-in-complex-samples
#13
Xueying Tu, Pir Muhammad, Jia Liu, Yanyan Ma, Shuangshou Wang, Danyang Yin, Zhen Liu
Glycoproteins play significant roles in many biological processes. Assays of glycoproteins have significant biological importance and clinical values, for which immunoassay has been the workhorse tool. However, immunoassay suffers from some disadvantages, such as poor availability of high-specificity antibodies and limited stability of biological reagents. Herein, we present an antibody-free and enzyme-free approach, called molecularly imprinted polymer (MIP)-based plasmonic immunosandwich assay (PISA), for fast and ultrasensitive detection of trace glycoproteins in complex samples...
December 20, 2016: Analytical Chemistry
https://www.readbyqxmd.com/read/28183452/controversies-in-the-management-of-hyperglycaemic-emergencies-in-adults-with-diabetes
#14
REVIEW
Luís Cardoso, Nuno Vicente, Dírcea Rodrigues, Leonor Gomes, Francisco Carrilho
Hyperglycaemic emergencies are associated with significant morbi-mortality and healthcare costs. Management consists on fluid replacement, insulin therapy, and electrolyte correction. However, some areas of patient management remain debatable. In patients without respiratory failure or haemodynamic instability, arterial and venous pH and bicarbonate measurements are comparable. Fluid choice varies upon replenishment phase and patient's condition. If patient is severely hypovolaemic, normal saline solution should be the first option...
March 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28179741/innovations-in-medication-preparation-safety-and-wastage-reduction-use-of-a-workflow-management-system-in-a-pediatric-hospital
#15
Stephen Jerome Davis, Josephine Hurtado, Rosemary Nguyen, Tran Huynh, Ivan Lindon, Cedric Hudnall, Sara Bork
Background: USP <797> regulatory requirements have mandated that pharmacies improve aseptic techniques and cleanliness of the medication preparation areas. In addition, the Institute for Safe Medication Practices (ISMP) recommends that technology and automation be used as much as possible for preparing and verifying compounded sterile products. Objective: To determine the benefits associated with the implementation of the workflow management system, such as reducing medication preparation and delivery errors, reducing quantity and frequency of medication errors, avoiding costs, and enhancing the organization's decision to move toward positive patient identification (PPID)...
January 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/28168338/radiation-exposure-to-the-patients-in-thoracic-and-lumbar-spine-fusion-using-a-new-intraoperative-cone-beam-computed-tomography-imaging-technique-a-preliminary-study
#16
Ludovic Kaminski, V Cordemans, O Cartiaux, M Van Cauter
PURPOSE: The goals of this paper are to assess the ionizing radiation exposure to the patients during thoracic and lumbar spinal fusion using a new intraoperative 3D imaging system and to evaluate the factors that could explain the variability in the observed doses. METHOD: We retrospectively reviewed 97 patients who underwent posterior instrumented thoracic and/or lumbar spinal fusion from December 2013 to November 2014. Primary data were the total dose area product (total DAP, Gy cm(2)) and total skin dose (total SD, mGy)...
February 6, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28165829/an-overview-of-nanofiber-based-antibacterial-drug-design
#17
Semih Calamak, Reza Shahbazi, Ipek Eroglu, Merve Gultekinoglu, Kezban Ulubayram
Introduction Conventional administration of antibacterial drugs to the human body can cause vital problems such as dose dependent systemic toxicity and bacterial resistance which prevent the healing process. In this regard, recent studies have been devoted to producing nanofiber based antibacterial drug delivery approaches which surpass bacterial resistance and toxicological issues. Areas covered This review summarizes latest developments in the production of antibacterial nanofibers, nanofiber based antibacterial action mechanisms and release profiles of nanofibers...
February 6, 2017: Expert Opinion on Drug Discovery
https://www.readbyqxmd.com/read/28162822/doses-per-vaccine-vial-container-an-understated-and-underestimated-driver-of-performance-that-needs-more-evidence
#18
REVIEW
Alexis Heaton, Kirstin Krudwig, Tina Lorenson, Craig Burgess, Andrew Cunningham, Robert Steinglass
The widespread use of multidose vaccine containers in low and middle income countries' immunization programs is assumed to have multiple benefits and efficiencies for health systems, yet the broader impacts on immunization coverage, costs, and safety are not well understood. To document what is known on this topic, how it has been studied, and confirm the gaps in evidence that allow us to assess the complex system interactions, the authors undertook a review of published literature that explored the relationship between doses per container and immunization systems...
February 2, 2017: Vaccine
https://www.readbyqxmd.com/read/28157640/radioactivity-levels-in-the-mostly-local-foodstuff-consumed-by-residents-of-the-high-level-natural-radiation-areas-of-ramsar-iran
#19
Nasrin Fathabadi, Ali Akbar Salehi, Kazem Naddafi, Mohammad Reza Kardan, Masud Yunesian, Ramin Nabizadeh Nodehi, Mohammad Reza Deevband, Molood Gooniband Shooshtari, Saeedeh Sadat Hosseini, Mahtab Karimi
Among High Level Natural Radiation Areas (HLNRAs) all over the world, the northern coastal city of Ramsar has been considered enormously important. Many studies have measured environmental radioactivity in Ramsar, however, no survey has been undertaken to measure concentrations in the diets of residents. This study determined the (226)Ra activity concentration in the daily diet of people of Ramsar. The samples were chosen from both normal and high level natural radiation areas and based on the daily consumption patterns of residents...
January 31, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28156443/a-single-dose-comparative-bioavailability-study-of-dronabinol-oral-solution-versus-dronabinol-capsules-in-healthy-volunteers
#20
Neha Parikh, William G Kramer, Varun Khurana, Santosh Vetticaden
: 198 Background: The capsule formulation of dronabinol, a pharmaceutical tetrahydrocannabinol (THC), is approved for anorexia associated with weight loss in patients with AIDS and for cancer chemotherapy-associated nausea/vomiting in patients with inadequate response to conventional antiemetics. A new oral formulation (i.e., dronabinol solution) was evaluated in a bioequivalence study versus currently marketed dronabinol capsules. METHODS: In an open-label, 2-treatment, 2-sequence, 4-period, single-dose crossover study, healthy volunteers were randomized to receive 1 of 2 treatment sequences (T-R-T-R or R-T-R-T; T = dronabinol 4...
October 9, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
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