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https://www.readbyqxmd.com/read/28936986/characterizing-endourologist-learning-curve-during-percutaneous-nephrolithotomy-implications-on-occupational-dose-and-patients
#1
Jacobo Guiu-Souto, Carlos Otero-Martínez, Daniel Pérez-Fentes, Carlos Fernández-Baltar, Juan F Sánchez-García, Camilo García-Freire, Miguel Pombar, Juan Pardo-Montero
In this study we have characterized the learning curve of percutaneous nephrolithotomy procedures over 301 cases for six years. Different surrogate parameters of clinical expertise have been used, such as dose area product, total procedure time, fluoroscopy time and personal equivalent doses. In addition, two different endourologists have been monitored; one of whom was subjected to a specific Radiation Protection training (ICRP 85). Eye lens dose is estimated from thermoluminescent dosimeters. Significant differences are observed between both endourologists, especially in the fluoroscopy time...
September 22, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28936890/radiation-dose-reduction-in-plain-radiography-of-the-full-length-lower-extremity-and-full-spine
#2
Mi Ran Jeon, Hee Jin Park, So Yeon Lee, Kyung A Kang, Eun Young Kim, Hyun Pyo Hong, Inyoung Youn
OBJECTIVE: To compare the diagnostic performance of standard- and low-dose radiographs of the full-length lower extremity and spine. MATERIALS AND METHODS: This study included 223 patients who visited our hospital and received full-length lower extremity standing radiographs and full-spine radiographs. We determined the dose area product (DAP) of each image, and effective doses (ED, mSv) were calculated based on the DAP. Subjective evaluation of the full-length radiographs was based on image quality, which was assessed by bony cortex and trabecula evaluation, and on diagnostic performance, which was assessed by leg length measurement...
September 22, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28934806/radiation-exposure-during-uterine-fibroid-embolization-ufe-a-confounder-controlled-comparison-between-a-state-of-the-art-angiography-unit-and-a-conventional-angiography-unit
#3
Christof-Matthias Sommer, Wieland Voigt, Michel Klapp Oliger, Christopher L Schlett, Stefan Erpenbach, Katrina Thomas, Andreas Hatopp, Patrick Kurz, Goetz M Richter
Purpose To compare radiation exposure of a state-of-the-art and a conventional angiography unit in patients undergoing uterine fibroid embolization (UFE). Materials and Methods Between January 2009 and December 2016, 286 patients underwent UFE in our Interdisciplinary Fibroid Center. The inclusion criteria for this retrospective analysis were first-time transarterial embolization for symptomatic fibroids, bilateral embolization, procedures applying a state-of-the-art (Group 1) or a conventional angiography unit (Group 2), and bilateral technical success with an adequate embolization endpoint after the injection of microspheres...
September 21, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28926095/model-based-assessment-using-conventional-bioequivalence-limits-to-ensure-safety-and-efficacy-of-rivaroxaban-in-patients-undergoing-hip-or-knee-replacement
#4
Mario González-Sales, Lanyan Fang, Myong-Jin Kim, Liang Zhao
We evaluated whether the current bioequivalence limit is adequate to ensure safety and efficacy of rivaroxaban in patients under total hip arthroplasty and total knee arthroplasty based on its model informed benefit/risk profile. Clinical data from a total of 7145 patients from 3 phase 2 and 4 phase 3 clinical trials were included in the current model-based exposure-response analysis. The relationships between rivaroxaban exposure measurements (ie, minimum or trough, maximum, average concentration, and area under the concentration-time curve [AUC] at steady state) and clinical outcomes (ie, the probabilities of major bleeding [MB] and venous thromboembolism [VTE]) were modeled using NONMEM 7...
September 19, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28923722/high-doses-of-ethylenediurea-edu-as-soil-drenches-did-not-increase-leaf-n-content-or-cause-phytotoxicity-in-willow-grown-in-fertile-soil
#5
Evgenios Agathokleous, Elena Paoletti, William J Manning, Mitsutoshi Kitao, Costas J Saitanis, Takayoshi Koike
Ground-level ozone (O3) levels are nowadays elevated in wide regions of the Earth, causing significant effects on plants that finally lead to suppressed productivity and yield losses. Ethylenediurea (EDU) is a chemical compound which is widely used in research projects as phytoprotectant against O3 injury. The EDU mode of action remains still unclear, while there are indications that EDU may contribute to plants with nitrogen (N) when the soil is poor in N and the plants have relatively small leaf area. To reveal whether the N content of EDU acts as a fertilizer to plants when the soil is not poor in N and the plants have relatively large total plant leaf area, willow plants (Salix sachalinensis Fr...
September 15, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28917081/evaluation-of-the-ecstasy-influence-on-tramadol-and-its-main-metabolite-plasma-concentration-in-rats
#6
Bardia Jamali, Behjat Sheikholeslami, Yalda Hosseinzadeh Ardakani, Hoda Lavasani, Mohammad-Reza Rouini
BACKGROUND: Tramadol is prone to be abused alone, or in combination with 3,4-methylenedioxymethamphetamine (MDMA, Ecstasy). It was reported that 95% of people with a history of substance abuse in the United States used tramadol in 2004. According to the WHO report in 2016, there was a growing number of tramadol abusers alone or in combination with psychoactive substances such as MDMA in particular in some Middle East countries. Higher concentrations of tramadol in plasma may lead to adverse drug reactions or lethal intoxication...
September 16, 2017: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/28916165/muc1-deficiency-exacerbates-pulmonary-fibrosis-in-a-mouse-model-of-silicosis
#7
Kosuke Kato, Marina A Zemskova, Alec D Hanss, Marianne M Kim, Sandra J Gendler, Ross Summer, Kwang Chul Kim
BACKGROUND: MUC1 (MUC in human and Muc in animals) is a membrane-tethered mucin expressed on the apical surface of lung epithelial cells. However, in the lungs of patients with interstitial lung disease, MUC1 is aberrantly expressed in hyperplastic alveolar type II epithelial (ATII) cells and alveolar macrophages (AM), and elevated levels of extracellular MUC1 are found in bronchoalveolar lavage (BAL) fluid and the serum of these patients. While pro-fibrotic effects of extracellular MUC1 have recently been described in cultured fibroblasts, the contribution of MUC1 to the pathobiology of pulmonary fibrosis is unknown...
September 12, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28911888/postoperative-imaging-of-orthopaedic-hardware-in-the-hand-and-wrist-is-there-an-added-value-for-tomosynthesis
#8
A De Silvestro, K Martini, A S Becker, T D L Kim-Nguyen, R Guggenberger, M Calcagni, T Frauenfelder
AIM: To prospectively investigate digital tomosynthesis (DTS) as an alternative to digital radiography (DR) for postoperative imaging of orthopaedic hardware after trauma or arthrodesis in the hand and wrist. MATERIALS AND METHODS: Thirty-six consecutive patients (12 female, median age 36 years, range 19-86 years) were included in this institutional review board approved clinical trial. Imaging was performed with DTS in dorso-palmar projection and DR was performed in dorso-palmar, lateral, and oblique views...
September 11, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28911627/assessment-of-the-pharmacokinetics-removal-rate-of-hemodialysis-and-safety-of-lactulose-in-hemodialysis-patients
#9
Cheng-Jui Lin, Chi-Feng Pan, Sy-Yeuan Ju, Hsuan-Kai Tzeng, Shen-Wei Chen, Jhu-Ting Syu, Chih-Jen Wu
Lactulose is often used to treat hepatic encephalopathy or constipation, and also exhibits benefits to chronic renal insufficiency due to reduce nitrogen-related products in serum. The present study investigated the pharmacokinetics of lactulose, its removal rate through dialysis, and safety by administering lactulose 6.5 g (Lagnos Jelly Divided Pack 16.05 g) orally to six hemodialysis patients who resided in Taiwan. As a result, the means of maximum plasma concentrations (Cmax) and Time to reach Cmax (Tmax) were 3090 ± 970 ng/mL and 6...
October 2016: Journal of Food and Drug Analysis
https://www.readbyqxmd.com/read/28904802/analytical-study-of-226-ra-activity-concentration-in-market-consuming-foodstuffs-of-ramsar-iran
#10
M Gooniband Shooshtari, M R Deevband, M R Kardan, N Fathabadi, A A Salehi, K Naddafi, M Yunesian, R Nabizadeh Nodehi, M Karimi, S S Hosseini
BACKGROUND: Ramsar, a city of Iran located on the coast of the Caspian Sea, has been considered to be enormously important due to its high natural radioactivity levels. People living in High Level Natural Radiation Areas (HLNRAs) have been exposed by several sources, one of which could be foodstuff. However, many studies have been carried out to measure the environmental radioactivity in Ramsar, but no survey has been conducted in all stapled consumed foods yet. This study was dedicated to determine (226)Ra activity concentration in the daily diets of Ramsar residents as a probable exposure...
2017: Journal of Environmental Health Science & Engineering
https://www.readbyqxmd.com/read/28893002/interventional-angiography-radiation-protection-for-the-examiner-by-using-lead-free-gloves
#11
Peter Kamusella, Fabian Scheer, Christopher Wilhelm Lüdtke, Philipp Wiggermann, Christian Wissgott, Reimer Andresen
INTRODUCTION: The radiation exposure to unprotected parts of the body requires special attention for the interventional radiologist. During angiographic procedures, hands are exposed to the direct X-ray beam and scattered radiation. AIM: The aim of the study was to evaluate the radiation exposure of examiners hand with the use of lead-free X-ray protective gloves in clinical practice in terms of shielding and sense of touch. The aim of the study was to evaluate the radiation exposure of examiners hand with the use of lead-free X-ray protective gloves in clinical practice in terms of shielding and sense of touch...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892483/quality-control-methods-for-aedes-albopictus-sterile-male-production
#12
Fabrizio Balestrino, Arianna Puggioli, Marco Carrieri, Jérémy Bouyer, Romeo Bellini
The capacity of the released sterile males to survive, disperse, compete with wild males and inseminate wild females is an essential prerequisite to be evaluated in any area-wide integrated pest management (AW-IPM) programs including a sterile insect release method. Adequate quality control tests supported by standardized procedures need to be developed to measure these parameters and to identify and correct potential inappropriate rearing or handling methods affecting the overall male quality. In this study, we report results on the creation and validation of the first quality control devices designed to infer the survival and mating capacity of radio-sterilized Aedes albopictus males through the observation of their flight capacity under restricted conditions (flight organ device) and after stress treatment (aspirator device)...
September 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28888725/-impact-of-rotational-coronary-angiography-in-the-amount-of-iodinated-contrast-and-the-exposition-to-ionizing-radiations-in-patients-undergoing-invasive-coronary-procedures-a-systematic-review-and-meta-analysis
#13
Diego Fernández-Rodríguez, Leydimar Anmad Shihadeh, José L Martos-Maine, Patricia Couto-Comba, Alejandro Quijada-Fumero, Raquel Pimienta, José J Grillo-Pérez, Marcos Rodríguez-Esteban, Horacio Pérez-Hernández, Julio Hernández-Afonso, Francisco Bosa Ojeda
BACKGROUND: Invasive coronary procedures involve the administration of iodinated contrast and the exposure to ionizing radiations, increasing morbidity and mortality. The rotational coronary angiography (RCA) allows acquiring multiple projections with a unique injection of iodinated contrast. To date, there were no meta-analysis specifically comparing RCA and conventional coronary angiography (CCA) in patients undergoing invasive coronary procedures, whether diagnostic or diagnostic and therapeutic...
September 6, 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28888220/pharmacokinetics-of-multiple-doses-of-co-crystal-of-tramadol-celecoxib-findings-from-a-4-way-randomized-open-label-phase-i-clinical-trial
#14
Sebastián Videla, Mounia Lahjou, Anna Vaqué, Mariano Sust, Marisol Escriche, Lluis Soler, Artur Sans, Eric Sicard, Neus Gascón, Gregorio Encina, Carlos Plata-Salamán
AIM: We compared the pharmacokinetic (PK) profiles of Co-Crystal of Tramadol-Celecoxib (CTC) versus each reference product (alone and in open combination) after single (first dose) and multiple dosing. METHODS: Healthy adults aged 18-50 years received, under fasted conditions, 15 twice-daily doses of the following treatments (separated by ≥14-day wash-out): 200 mg immediate-release (IR) CTC (equivalent to 88 mg tramadol and 112 mg celecoxib; Treatment-1); 100 mg IR tramadol (Treatment-2), 100 mg celecoxib (Treatment-3); and 100 mg IR tramadol and 100 mg celecoxib (Treatment-4)...
September 9, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28887670/comparison-of-two-endovascular-steerable-robotic-catheters-for-percutaneous-robot-assisted-fibroid-embolization
#15
C Del Giudice, O Pellerin, M Nouri Neville, G Amouyal, I Fitton, C Leré-Déan, M Sapoval
PURPOSE: To compare outcomes of percutaneous robot-assisted uterine fibroid embolization (UFE) using two different endovascular robotic catheters. METHODS: Twenty-one patients with a symptomatic uterine fibroid were prospectively enrolled in a single-center study to be treated with a percutaneous robot-assisted embolization using the Magellan system. Fourteen patients were treated using a first generation steerable robotic catheter, version 1.0 (group 1), and seven were treated using the new version 1...
September 8, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28886949/low-antigen-dose-formulated-in-caf09-adjuvant-favours-a-cytotoxic-t-cell-response-following-intraperitoneal-immunization-in-g%C3%A3-ttingen-minipigs
#16
Nana H Overgaard, Thomas M Frøsig, Jeanne T Jakobsen, Søren Buus, Mads H Andersen, Gregers Jungersen
The relationship between the antigen dose and the quality of an immune response generated upon immunization is poorly understood. However, findings show that the immune system is indeed influenced by the antigen dose; hence underlining the importance of correctly determining which dose to use in order to generate a certain type of immune response. To investigate this area further, we used Göttingen minipigs asan animal model especially due to the similar body size and high degree of immunome similarity between humans and pigs...
September 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28886699/research-on-advanced-intervention-using-novel-bone-marrow-stem-cell-rainbow-a-study-protocol-for-a-phase-i-open-label-uncontrolled-dose-response-trial-of-autologous-bone-marrow-stromal-cell-transplantation-in-patients-with-acute-ischemic-stroke
#17
Hideo Shichinohe, Masahito Kawabori, Hiroaki Iijima, Tuyoshi Teramoto, Takeo Abumiya, Naoki Nakayama, Ken Kazumata, Shunsuke Terasaka, Teruyo Arato, Kiyohiro Houkin
BACKGROUND: Stroke is a leading cause of death and disability, and despite intensive research, few treatment options exist. However, a recent breakthrough in cell therapy is expected to reverse the neurological sequelae of stroke. Although some pioneer studies on the use of cell therapy for treating stroke have been reported, certain problems remain unsolved. Recent studies have demonstrated that bone marrow stromal cells (BMSCs) have therapeutic potential against stroke. We investigated the use of autologous BMSC transplantation as a next-generation cell therapy for treating stroke...
September 8, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28885191/radiation-dose-and-risk-in-children-undergoing-cardiac-interventions-performed-using-flat-detector-angiography-systems
#18
Anna Varghese, A Devi, Paul V George, Roshan Samuel Livingstone
The purpose of the study was to measure radiation doses and estimate risk from various beam projections in children undergoing cardiac interventions. The dose area product (DAP) was measured for 11 patent ductus arteriosus device closure, PDA; 4 atrial septal defect device closure, ASD and 3 balloon pulmonary valvuloplasty, BPV interventions performed using flat detector system. Total mean DAP for PDA, ASD and BPV were 1.9 Gycm2, 9.8 Gycm2 and 6.2 Gycm2 respectively. The fluoroscopic kerma dose rates increased by 10%, 33% and 92% when changing projection from posterior-anterior to lateral projection for PDA interventions among infants, <5yrs and > 5yrs respectively...
September 8, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28882497/pulmonary-vein-isolation-for-atrial-fibrillation-can-be-achieved-with-low-radiation-exposure
#19
Alex L Huang, Nadeem Mughal, Ferdinand Tabas, Natalie L Patterson, Wen Kai Wong, David Whalley, Logan Kanagaratnam
BACKGROUND: Atrial fibrillation is common and management by pharmacotherapy is limited by modest efficacy and significant toxicities. Pulmonary vein isolation (PVI) is a safe and effective alternative in select patients with atrial fibrillation. However, prolonged procedure time raises concerns of health risks from radiation exposure. This study aims to determine the significance of radiation exposure from PVI. METHODS: In this study, we retrospectively reviewed patient demographics, fluoroscopy time, entrance skin dose and dose area product in 80 cases of PVI, radiofrequency ablation for atrial flutter and diagnostic coronary angiogram performed in our institution...
August 8, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28881325/biodegradation-of-high-doses-of-commercial-pesticide-products-in-pilot-scale-biobeds-using-olive-oil-agroindustry-wastes
#20
L Delgado-Moreno, R Nogales, E Romero
Biobeds systems containing soil, peat and straw (SPS) are used worldwide to eliminate pesticide point-source contamination, but implantation is difficult when peat and/or straw are not available. Novel biobeds composed of soil, olive pruning and wet olive mill cake (SCPr) or its vermicompost (SVPr) were assayed at pilot scale for its use in olive grove areas. Their removal efficiency for five pesticides applied at high concentration was compared with the biobed with SPS. The effect of a grass layer on the efficiency of these biobeds was also evaluated...
September 4, 2017: Journal of Environmental Management
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