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https://www.readbyqxmd.com/read/28641022/a-randomized-single-dose-parallel-study-on-enhancement-of-nitric-oxide-in-serum-and-saliva-with-the-use-of-natural-sports-supplement-in-healthy-adults
#1
Joby Jacob, Sreeraj Gopi, Chandradhara Divya
Sports supplements that stimulate the production of nitric oxide (NO) are widely promoted agents in the sports nutrition domain, and nitric oxide plays an important role to enhance the cardiovascular and physical fitness of the sports participants. The purpose of the study is to investigate whether oral intake of a sports nutritional supplement (Fitnox) is able to increase nitrate (NO3(-)) and nitrite (NO2(-)) levels in blood serum and saliva of healthy adults. Fitnox is a unique blend of Kaempferia parviflora methoxy flavones, pomegranate peel polyphenols, and Moringa oleifera leaf saponins...
June 22, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28636805/a-hybrid-phantom-system-for-patient-skin-and-organ-dosimetry-in-fluoroscopically-guided-interventions
#2
David Borrego, Daniel Siragusa, Stephen Balter, Wesley E Bolch
To investigate calibrations for improved estimates of skin dose and to develop software for computing absorbed organ doses for fluoroscopically guided interventions (FGIs) with the use of radiation dose structured reports (RDSR) and the UF/NCI family of hybrid computational phantoms METHODS AND MATERIALS: Institutional review board approval was obtained for this retrospective study in which ten RDSRs were selected for their high cumulative reference air kerma values. Skin doses were computed using the University of Florida's rapid in-clinic peak skin dose algorithm (or UF-RIPSA)...
June 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28631620/effectiveness-of-pelvic-lead-blanket-to-reduce-the-doses-to-eye-lens-and-hands-of-interventional-cardiologists-and-assistant-nurses
#3
Włodzimierz Grabowicz, Joanna Karolina Domienik-Andrzejewska, Konrad Masiarek, Tomasz Górnik, Tomasz Grycewicz, Marcin Brodecki, Andrzej Lubiński
The aim of the present study is to analyse quantitatively the potential reduction of the doses to eye lens and the hands of an operator and a nurse by the pelvic lead blanket during coronary angiography (CA) and percutaneous transluminal coronary angioplasty (PTCA) procedures. Thermoluminescent dosimeters (TLDs) were used to assess dose levels to left eye lens and left and right fingers of both physician and nurses during single procedures performed with or without lead blanket. The measurements were carried out in one medical centre and include dosimetric data from100 procedures...
June 20, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/28625505/bioequivalence-study-of-a-new-fixed-dose-combination-tablet-containing-s-amlodipine-nicotinate-and-olmesartan-medoxomil-in-healthy-korean-male-subjects
#4
Mi Jin Oh, Hyun Hwan Hwang, Hyun Gyu Kim, Geun Hyeog Lee, Yun-Seok Cho, Sun Young Lee, Soo Yeon Kang, Kyung Hee Cho, Yun Young Lee, Yun Jeong Lee, Choon-Gon Jang, Seok-Yong Lee
PURPOSE: A fixed-dose combination (FDC) pill of amlodipine (relatively old calcium channel blocker as dihydropyridine) and olmesartan (relatively new angiotensin II receptor blocker) is used for hypertension that is not adequately controlled with a single-formulation drug. Because the FDC is a one-pill formulation, and amlodipine and olmesartan have different mechanisms of action, it is expected to improve patients' medication compliance and have an increased blood pressure-lowering efficacy...
June 15, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28624279/the-use-of-national-level-data-to-describe-trends-in-intramammary-antimicrobial-usage-on-irish-dairy-farms-from-2003-to-2015
#5
Simon J More, Tracy A Clegg, Finola McCoy
In this study, we used national-level data to describe trends in on-farm intramammary antimicrobial usage in Ireland from 2003 to 2015. We calculated actual sales of intramammary tubes and the quantity of active substance sold, by year, product type [lactation or dry cow therapy (DCT)], antimicrobial group, World Health Organization antimicrobial classification, and from 2009 to 2015, prescribing route. We also estimated on-farm usage of lactation and dry cow intramammary antimicrobials using defined daily dose (DDDvet) and defined course dose (DCDvet) calculations, and dry cow coverage...
June 14, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28619456/how-does-secondary-processing-affect-the-physicochemical-properties-of-inhalable-salbutamol-sulphate-particles-a-temporal-investigation
#6
Joana T Pinto, Snezana Radivojev, Sarah Zellnitz, Eva Roblegg, Amrit Paudel
As pulmonary drug delivery is extended from low doses to high doses, physicochemical characteristics of the active pharmaceutical ingredient gain importance in the development of dry powder inhalers. Therefore, the present work aims to understand the impact of distinct engineering techniques on the process induced physicochemical characteristics of salbutamol sulphate particles over time. The particle engineering techniques chosen were jet-milling and spray-drying, two well used processes in the production of predominately crystalline and amorphous inhalable particles, respectively...
June 12, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28618036/ultra-low-radiation-dose-during-electrophysiology-procedures-using-optimised-new-generation-fluoroscopy-technology
#7
James Crowhurst, Haris Haqqani, Daniel Wright, Daniel Wright, Mark Whitby, Adam Lee, John Betts, Russell Denman
BACKGROUND: Electrophysiology procedures require fluoroscopic guidance, with the associated potentially adverse effects of ionising radiation. Newer fluoroscopy systems have more features that enable dose-reduction strategies. This study aimed to investigate any reduction in radiation dose between an older fluoroscopy system (Philips Integris H5000) and one of the latest systems (Siemens Artis Q), optimised with dose-reduction strategies. METHODS: Radiation dose measures were collected over a two year period in a single electrophysiology laboratory...
June 15, 2017: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/28617060/levonorgestrel-releasing-intrauterine-system-lng-ius-12-for-prevention-of-pregnancy-for-up-to-five-years
#8
Anita L Nelson
A new five-year low dose, smaller-framed, levonorgestrel-releasing intrauterine contraceptive system (LNG-IUS 12) has been introduced to complement the currently available systems. Areas Covered: This article will provide an overview of this new intrauterine system - its composition and its mechanisms of action as well as the results of the Phase II and III clinical trials of its efficacy, safety and tolerability. Expert Commentary: This new LNG-IUS 12 provides five-year contraceptive protection a pregnancy rate (less than 1%) in first year of use, which puts it into the top tier with the existing LNG-IUS 20 products; however, the LNG-IUS 12 does not have the high rates of amenorrhea often seen with the higher dose devices...
June 19, 2017: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/28614264/extremely-low-frame-rate-digital-fluoroscopy-in-catheter-ablation-of-atrial-fibrillation-a-comparison-of-2-versus-4-frame-rate
#9
Ji Hyun Lee, Jun Kim, Minsu Kim, Jongmin Hwang, You Mi Hwang, Joon-Won Kang, Gi-Byoung Nam, Kee-Joon Choi, You-Ho Kim
Despite the technological advance in 3-dimensional (3D) mapping, radiation exposure during catheter ablation of atrial fibrillation (AF) continues to be a major concern in both patients and physicians. Previous studies reported substantial radiation exposure (7369-8690 cGy cm) during AF catheter ablation with fluoroscopic settings of 7.5 frames per second (FPS) under 3D mapping system guidance. We evaluated the efficacy and safety of a low-frame-rate fluoroscopy protocol for catheter ablation for AF.Retrospective analysis of data on 133 patients who underwent AF catheter ablation with 3-D electro-anatomic mapping at our institute from January 2014 to May 2015 was performed...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28609790/analysis-of-patients-x-ray-exposure-in-146-percutaneous-radiologic-gastrostomies
#10
Tim Ole Petersen, Martin Reinhardt, Jochen Fuchs, Dieter Gosch, Alexey Surov, Patrick Stumpp, Thomas Kahn, Michael Moche
Purpose Analysis of patient´s X-ray exposure during percutaneous radiologic gastrostomies (PRG) in a larger population. Materials and Methods Data of primary successful PRG-procedures, performed between 2004 and 2015 in 146 patients, were analyzed regarding the exposition to X-ray. Dose-area-product (DAP), dose-length-product (DLP) respectively, and fluoroscopy time (FT) were correlated with the used x-ray systems (Flatpanel Detector (FD) vs. Image Itensifier (BV)) and the necessity for periprocedural placement of a nasogastric tube...
June 13, 2017: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/28608158/surface-water-mitigates-the-anti-metamorphic-effects-of-elevated-perchlorate-concentrations-in-new-mexico-spadefoot-toad-larvae-spea-multiplicata
#11
Melissa A Sandoz, Mike Wages, Kim J Wooten, Sheree L Clendening, Lucas R Smith, Brian Mulhearn, Philip N Smith
Perchlorate (ClO4(-)) has potential to negatively impact amphibian populations by inhibiting thyroid hormone production, and thus metamorphosis in developing larvae. However, variability exists in species sensitivity, and there is evidence suggesting that natural surface waters can mitigate the anti-metamorphic potential of perchlorate. New Mexico spadefoot toad tadpoles, Spea multiplicata, were exposed to natural surface waters spiked with nominal concentrations of 0, 1000, 1350, 1710, 3000, 5110, and 8000 μg/L perchlorate ion for up to 42 days...
June 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28605864/time-trends-in-radiocaesium-in-the-japanese-diet-following-nuclear-weapons-testing-and-chernobyl-implications-for-long-term-contamination-post-fukushima
#12
Jim T Smith, Keiko Tagami, Shigeo Uchida
Estimation of time changes in radiocaesium in foodstuffs is key to predicting the long term impact of the Fukushima accident on the Japanese diet. We have modelled >4000 measurements, spanning 50 years, of (137)Cs in foodstuffs and whole diet in Japan after nuclear weapons testing (NWT) and the Chernobyl accident. Broadly consistent long term trends in (137)Cs activity concentrations are seen between different agricultural foodstuffs; whole diet follows this general trend with remarkably little variation between averages for different regions of Japan...
June 8, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28602688/quality-control-in-cone-beam-computed-tomography-cbct-efomp-estro-iaea-protocol-summary-report
#13
Hugo de Las Heras Gala, Alberto Torresin, Alexandru Dasu, Osvaldo Rampado, Harry Delis, Irene Hernández Girón, Chrysoula Theodorakou, Jonas Andersson, John Holroyd, Mats Nilsson, Sue Edyvean, Vesna Gershan, Lama Hadid-Beurrier, Christopher Hoog, Gregory Delpon, Ismael Sancho Kolster, Primož Peterlin, Julia Garayoa Roca, Paola Caprile, Costas Zervides
The aim of the guideline presented in this article is to unify the test parameters for image quality evaluation and radiation output in all types of cone-beam computed tomography (CBCT) systems. The applications of CBCT spread over dental and interventional radiology, guided surgery and radiotherapy. The chosen tests provide the means to objectively evaluate the performance and monitor the constancy of the imaging chain. Experience from all involved associations has been collected to achieve a consensus that is rigorous and helpful for the practice...
June 8, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28601790/the-feasibility-study-of-autotrophic-denitrification-with-iron-sludge-produced-for-sulfide-control
#14
Yangyang Wei, Ji Dai, Hamish R Mackey, Guang-Hao Chen
Ferric iron is widely dosed in wastewater treatment plants dealing with sulfide for septicity control, which generates a great amount of iron-rich chemical sludge that is challenging and costly to dispose. This study investigates the feasibility of using this iron sludge as the electron donor for autotrophic denitrification, not only realizing high nitrogen removal efficiency without additional carbon source requirement, but also partially mitigating iron-rich chemical sludge disposal and reduce sludge production by enriching low-yield autotrophic denitrifiers in the system...
June 1, 2017: Water Research
https://www.readbyqxmd.com/read/28595315/determination-of-local-levels-of-radiation-exposure-in-orthopedic-interventions-using-structured-dose-report-data-drawn-from-the-hospital-picture-archiving-and-communication-system
#15
Carlo Giordano, Ivo Monica, Rossana Gobbi, Lorenzo Barbattini
The aim of this study was to determine the dosimetric parameters of radiation to which orthopedic in-patients are exposed, using data drawn from the hospital's picture archiving and communication system. Data for 310 patients, relating to seven different anatomical districts, were examined. Femoral operations were divided into three types. The 75th percentile dose at the interventional reference point (IRP) exceeded 2 mGy only for femoral interventions (4.6-6.2 mGy) with 75th percentile kerma-area product (KAP) values ranging from 84...
June 8, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/28594286/peroxisomes-as-modulators-of-cellular-protein-thiol-oxidation-a-new-model-system
#16
Celien Lismont, Marcus Nordgren, Chantal Brees, Bernard Knoops, Paul P Van Veldhoven, Marc Fransen
<b><i>Aims:</i></b> Peroxisomes are ubiquitous, single membrane-bounded organelles that contain considerable amounts of enzymes involved in the production or breakdown of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>), a key signaling molecule in multiple biological processes and disease states. Despite this, the role of this organelle in cross-compartmental H<sub>2</sub>O<sub>2</sub> signaling remains largely unclear, mainly because of the difficulty to modulate peroxisomal H<sub>2</sub>O<sub>2</sub> production in a selective manner...
June 8, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28591833/a-new-fully-human-recombinant-fsh-follitropin-epsilon-two-phase-i-randomized-placebo-and-comparator-controlled-pharmacokinetic-and-pharmacodynamic-trials
#17
Khalid Abd-Elaziz, Ingrid Duijkers, Lars Stöckl, Bruno Dietrich, Christine Klipping, Kelvin Eckert, Steffen Goletz
STUDY QUESTION: What are the differences and similarities of pharmacokinetic (PK) and pharmacodynamic (PD) characteristics of the novel recombinant human FSH follitropin epsilon expressed in the human cell line GlycoExpress compared with a Chinese hamster ovary (CHO) derived compound and a urinary derived product? SUMMARY ANSWER: Overall follitropin epsilon, with a fully human glycosylation, shows a comparable PK profile at single-dose as well as multiple-dose administration compared to recombinant CHO-derived FSH as well as urinary derived FSH, whereas the PD properties differ from product to product with follitropin epsilon being most active in PD parameters...
June 7, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28587612/lipodox%C3%A2-generic-doxorubicin-hydrochloride-liposome-injection-in-vivo-efficacy-and-bioequivalence-versus-caelyx%C3%A2-doxorubicin-hydrochloride-liposome-injection-in-human-mammary-carcinoma-mx-1-xenograft-and-syngeneic-fibrosarcoma-wehi-164-mouse-models
#18
Vinod Burade, Subhas Bhowmick, Kuntal Maiti, Rishit Zalawadia, Harry Ruan, Rajamannar Thennati
BACKGROUND: Doxorubicin (DXR) hydrochloride (HCl) liposome injection is an important part of the treatment armamentarium for a number of cancers. With growing needs for affordable and effective anticancer treatments, the development of generics is becoming increasingly important to facilitate patient access to vital medications. We conducted studies in relevant mouse models of cancer to compare the preclinical antitumour efficacy and plasma pharmacokinetic profile of a proposed generic DXR HCl liposome injection developed by Sun Pharmaceutical Industries Ltd...
June 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28583647/institutional-local-diagnostic-reference-levels-in-fluoroscopically-guided-spine-surgery
#19
Vasileios I Metaxas, Gerasimos A Messaris, George D Gatzounis, Fotios N Tzortzidis, Dimitrios T Konstantinou, George S Panayiotakis
In this study, institutional (local) diagnostic reference levels (LDRLs) and action levels (ALs) for spine interventional procedures are reported. Fluoroscopy time (FT), kerma area product (KAP), cumulative dose (CD), as well as anatomical, clinical and technical factors affecting procedure complexity were recorded for 156 patients who underwent cervical and thoraco-lumbar interventions. Patient entrance surface dose (ESD), effective dose (ED), thyroid absorbed dose and gonadal dose were also estimated, based on KAP measurements...
May 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28581263/dose-decreasing-effect-of-the-first-reversed-laser-beam-collimator-for-c-arm-type-angiographic-equipment
#20
Yeong Cheol Heo, Jae Hwan Cho, Dong Kyoon Han
This is a study on the dose-decreasing effect of the first reversed laser beam collimator (RLBC) for C-arm type angiographic equipment. A laser beam was located at the center of each plane at an oblique angle to the angiographic equipment detector. A field of view, which could be seen with the naked eye, was made by focusing the laser beam in the direction of the X-ray source. The height of the table was fixed at 75 cm and the iron balls were located within 2 mm of the top, bottom, left, and right edges of the output image...
July 2017: Journal of Korean Medical Science
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