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https://www.readbyqxmd.com/read/29780829/the-effect-of-c-arm-mobility-and-field-of-vision-on-radiation-exposure-in-the-treatment-of-proximal-femoral-fractures-a-randomized-clinical-trial
#1
Mahmut Kalem, Kerem Başarır, Hakan Kocaoğlu, Ercan Şahin, Hakan Kınık
Objectives: To examine the effect of fluoroscopy devices with different sizes of image intensifier and C-arm maneuverability on operating time, fluoroscopy time, radiation dose and reduction, and fixation quality at intertrochanteric femoral fractures. Design: Single-center, randomized, prospective study. Setting: Academic Level I trauma hospital. Patients and Intervention: 34 patients treated with cephalomedullary nailing for a stable, intertrochanteric proximal femur fracture (OTA A1)...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29780236/pharmacokinetic-comparison-of-a-fixed-dose-combination-versus-concomitant-administration-of-fimasartan-amlodipine-and-rosuvastatin-using-partial-replicated-design-in-healthy-adult-subjects
#2
Minkyung Oh, Jong-Lyul Ghim, Sung-Eun Park, Eun-Young Kim, Jae-Gook Shin
Objective: The aim of this study was to compare the pharmacokinetics (PK) and safety profiles of a fixed-dose combination (FDC) formulation of fimasartan, amlodipine, and rosuvastatin with the co-administration of the two products by using a replicated crossover study design in healthy male subjects. Results: This was an open-label, randomized, three-sequence, three-period replicated crossover study in healthy male subjects. The replicated crossover design was done because of high coefficient of variation of PK parameter for fimasartan, that is, >30%...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29775914/current-radiological-situation-in-areas-of-ukraine-contaminated-by-the-chernobyl-accident-part-1-human-dietary-exposure-to-caesium-137-and-possible-mitigation-measures
#3
I Labunska, V Kashparov, S Levchuk, D Santillo, P Johnston, S Polishchuk, N Lazarev, Y Khomutinin
This study reports for the first time temporal trends for the period of 2011-2016 in 137 Cs content in cow's milk originating from private farms and households of 14 settlements located in the territories of the Rivne region, Ukraine. These areas are still radioactively contaminated as a result of the accident at the Chernobyl Nuclear Power Plant (ChNPP) in 1986. In 2016, the average 137 Cs activity concentration in milk exceeded the Ukrainian Permissible Level (PL) for adults of 100 Bq/l in samples from 6 settlements and the PL for children of 40 Bq/l in 8 settlements, reaching activity concentration of around 500 Bq/l in some samples...
May 15, 2018: Environment International
https://www.readbyqxmd.com/read/29770154/effects-of-platycodin-d-on-reflux-esophagitis-due-to-modulation-of-antioxidant-defense-systems
#4
Su-Yeon Cho, Chang-Hyun Song, Ji-Eun Lee, Seong Hun Choi, Sae-Kwang Ku, Soo-Jin Park
Aims: The effects of platycodin D (PD) pretreatment were examined in reflux esophagitis (RE) induced rats. Methods: Sham, control, and omeprazole (OMP) group were pretreated with distilled water or OMP as a reference, respectively, and PD pretreated groups were given 3 different PD doses once a day for 7 days. One hour after last pretreatment, RE was induced by ligation of the forestomach and pylorus. At 8 h after operation, all animals were sacrificed. Results: PD showed significant dose-dependent reduction of gastric secretion, myeloperoxidase activity, and RE lesion areas of esophagus and stomach mucosa...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29763951/dynamic-4d-ct-angiography-for-guiding-transarterial-chemoembolization-impact-on-the-reduction-of-contrast-material-operator-radiation-exposure-catheter-consumption-and-diagnostic-confidence
#5
Moritz H Albrecht, Thomas J Vogl, Julian L Wichmann, Simon S Martin, Jan-Erik Scholtz, Sebastian Fischer, Renate M Hammerstingl, Marc Harth, Nour-Eldin A Nour-Eldin, Axel Thalhammer, Stephan Zangos, Ralf W Bauer
PURPOSE:  This study was carried out to investigate the impact of abdominal dynamic four-dimensional CT angiography (4D-CTA) for guiding transarterial chemoembolization (TACE) on the amount of contrast material used, operator radiation exposure, catheter consumption, and diagnostic confidence. MATERIALS AND METHODS:  Written consent was waived for this IRB-approved retrospective study. 29 patients (20 men; mean age: 65.7 ± 11.5 years) with malignant liver lesions underwent 4D-CTA, prior to initial TACE...
June 2018: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/29760949/new-patient-controlled-abdominal-compression-method-in-radiography-radiation-dose-and-image-quality
#6
Oili Piippo-Huotari, Eva Norrman, Agneta Anderzén-Carlsson, Håkan Geijer
Background: The radiation dose for patients can be reduced with many methods and one way is to use abdominal compression. In this study, the radiation dose and image quality for a new patient-controlled compression device were compared with conventional compression and compression in the prone position . Purpose: To compare radiation dose and image quality of patient-controlled compression compared with conventional and prone compression in general radiography. Material and Methods: An experimental design with quantitative approach...
May 2018: Acta Radiologica Open
https://www.readbyqxmd.com/read/29758592/comparison-of-a-therapeutic-only-versus-prophylactic-platelet-transfusion-policy-for-people-with-congenital-or-acquired-bone-marrow-failure-disorders
#7
REVIEW
Reem Malouf, Asma Ashraf, Andreas V Hadjinicolaou, Carolyn Doree, Sally Hopewell, Lise J Estcourt
BACKGROUND: Bone marrow disorders encompass a group of diseases characterised by reduced production of red cells, white cells, and platelets, or defects in their function, or both. The most common bone marrow disorder is myelodysplastic syndrome. Thrombocytopenia, a low platelet count, commonly occurs in people with bone marrow failure. Platetet transfusions are routinely used in people with thrombocytopenia secondary to bone marrow failure disorders to treat or prevent bleeding. Myelodysplastic syndrome is currently the most common reason for receiving a platelet transfusion in some Western countries...
May 14, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29758420/assessment-of-the-impact-of-three-pesticides-on-microbial-dynamics-and-functions-in-a-lab-to-field-experimental-approach
#8
P A Karas, C Baguelin, G Pertile, E S Papadopoulou, S Nikolaki, V Storck, F Ferrari, M Trevisan, A Ferrarini, F Fornasier, S Vasileiadis, G Tsiamis, F Martin-Laurent, D G Karpouzas
The toxicity of pesticides on soil microorganisms is as an emerging area of concern. Novel and well-standardized tools could be now used to provide a robust assessment of the ecotoxicity of pesticides on soil microorganisms. We followed a tiered lab-to-field approach to assess the toxicity of three pesticides, widely used at EU level, (chlorpyrifos (CHL), isoproturon (IPU) and tebuconazole (TBZ)) on (i) the abundance of 11 microbial taxa and 8 functional microbial groups via q-PCR and (ii) the activity of enzymes involved in biogeochemical cycles via fluorometric analysis...
May 11, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29758360/single-ingestion-of-di-2-propylheptyl-phthalate-dphp-by-male-volunteers-dphp-in-blood-and-its-metabolites-in-blood-and-urine
#9
D Klein, W Kessler, C Pütz, B Semder, W Kirchinger, A Langsch, W Gries, R Otter, A K E Gallien, X Wurzenberger, J G Filser
Di-(2-propylheptyl) phthalate (DPHP) is used as a plasticizer for polyvinyl chloride products. A tolerable daily intake of DPHP of 0.2 mg/kg body weight has been derived from rat data. Because toxicokinetic data of DPHP in humans were not available, it was the aim of the present work to monitor DPHP and selected metabolites in blood and urine of 6 male volunteers over time following ingestion of a single DPHP dose (0.7 mg/kg body weight). Concentration-time courses in blood were obtained up to 24 h for DPHP, mono-(2-propylheptyl) phthalate (MPHP), mono-(2-propyl-6-hydroxyheptyl) phthalate (OH-MPHP), and mono-(2-propyl-6-oxoheptyl) phthalate (oxo-MPHP); amounts excreted in urine were determined up to 46 h for MPHP, OH-MPHP, oxo-MPHP, and mono-(2-propyl-6-carboxyhexyl) phthalate (cx-MPHP)...
May 11, 2018: Toxicology Letters
https://www.readbyqxmd.com/read/29753675/patient-radiation-exposure-in-transradial-versus-transfemoral-yttrium-90-radioembolization-a-retrospective-propensity-score-matched-analysis
#10
Joshua Loewenstern, Colton Welch, Safet Lekperic, Vivian Bishay, Mona Ranade, Rahul S Patel, Edward Kim, F Scott Nowakowski, Robert A Lookstein, Aaron M Fischman
PURPOSE: To compare differences in patient radiation exposure (PRE) during transarterial yttrium-90 (90 Y) radioembolization (TARE) between transradial access (TRA) and transfemoral access (TFA). MATERIALS AND METHODS: A total of 810 consecutive first-time TARE procedures in patients from 2013 to 2017 were retrospectively reviewed. A propensity score-matching (PSM) analysis matched TRA and TFA groups on the basis of patient age, sex, weight, height, cancer type, 90 Y microsphere type, and number of previous procedures from the same and opposite approaches...
May 9, 2018: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29752541/stratum-corneum-substantivity-drug-development-implications
#11
REVIEW
Becky S Li, John Havens Cary, Howard I Maibach
There are at least 15 factors that influence the ability of chemicals to penetrate the skin. Substantivity is yet another factor and allows penetrants to remain on and in skin for many days. As many skin pathologies involve stratum corneum and require multiple dosing of topicals, understanding substantivity mechanisms may provide insight for topical dosing strategies. Substantivity is also of importance in the development of other consumer products that necessitate adherence to skin, including sunscreens, insect repellents, and cosmetics...
May 11, 2018: Archives of Dermatological Research
https://www.readbyqxmd.com/read/29749631/persistence-of-a-posaconazole-mediated-drug-drug-interaction-with-ranolazine-after-cessation-of-posaconazole-administration-impact-of-obesity-and-implications-for-patient-safety
#12
Christina R Chow, Jerold S Harmatz, Michael J Ryan, David J Greenblatt
The antianginal agent ranolazine (Ranexa®) is metabolized primarily by cytochrome P450-3A (CYP3A) enzymes. Coadministration with strong CYP3A inhibitors, such as ketoconazole and posaconazole, is contraindicated due to risk of QT prolongation from high levels of ranolazine. This study evaluated the time course of recovery from the posaconazole drug interaction in normal-weight and otherwise healthy obese subjects. Subjects received single doses of ranolazine in the baseline control condition, again during coadministration of posaconazole, and at 4 additional time points during the 2 weeks after posaconazole discontinuation...
May 11, 2018: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29747318/-effects-of-glycyrrhizic-acid-on-erk1-2-and-p38-mapk-signaling-pathway-in-a-murine-model-of-asthma
#13
W Y Zhang, Y C Gu, Y Tang, Q Z Wu
Objective: To explore the effects of glycyrrhizic acid (GA) on Extracellular regulated protein kinases (ERK1/2) and p38 mitogen-activated protein kinases (p38 MAPK) signaling pathways in a murine model of asthma. Methods: Sixty female BALB/c mice were randomly divided into 6 groups ( n =10 each): a control group, an asthmatic group, two treatment groups with low and high doses of GA, U0126 group and SB203580 group. Within 24 hours after the last OVA challenge, histological studies of lung were conducted with the hematoxylin and eosin staining (HE) and alcian blue-periodic acid-Schiff (AB-PAS), the relative protein expression of ERK1/2 and p38 MAPK were detected by immunohistochemistry and Western blotting in vivo ...
April 24, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29747109/characterization-of-airborne-particles-emitted-by-an-electrically-heated-tobacco-smoking-system
#14
A Pacitto, L Stabile, M Scungio, V Rizza, G Buonanno
Smoking activities were recognized as a main risk factor for population. Indeed, mainstream smoke aerosol is directly inhaled by smokers then delivering harmful compounds in the deepest regions of the lung. In order to reduce the potential risk of smoking, different nicotine delivery products have been recently developed. The latest device released is an electrically heated tobacco system (iQOS® , Philip Morris) which is able to warm the tobacco with no combustion. In the present paper a dimensional and volatility characterization of iQOS-generated particles was performed through particle number concentration and distribution measurements in the mainstream aerosol...
May 7, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29746721/melatonin-for-the-promotion-of-sleep-in-adults-in-the-intensive-care-unit
#15
REVIEW
Sharon R Lewis, Michael W Pritchard, Oliver J Schofield-Robinson, Phil Alderson, Andrew F Smith
BACKGROUND: Patients in the intensive care unit (ICU) experience sleep deprivation caused by environmental disruption, such as high noise levels and 24-hour lighting, as well as increased patient care activities and invasive monitoring as part of their care. Sleep deprivation affects physical and psychological health, and patients perceive the quality of their sleep to be poor whilst in the ICU. Artificial lighting during night-time hours in the ICU may contribute to reduced production of melatonin in critically ill patients...
May 10, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29740768/influence-of-composted-poultry-manure-and-irrigation-regimes-on-some-morpho-physiology-parameters-of-maize-under-semiarid-environments
#16
Wajid Farhad, Mumtaz Akhtar Cheema, Hafiz Mohkum Hammad, Muhammad Farrukh Saleem, Shah Fahad, Farhat Abbas, Ikramullah Khosa, Hafiz Faiq Bakhat
Poultry manure (PM), a rich source for crop nutrients, is produced in ample quantities worldwide. It provides necessary nutrient to soil and has a potential to improve plant water holding availability under semiarid environment. The effect of composted poultry manure (CPM) and irrigation regimes on morpho-physiology of selective maize (Zea mays L.) hybrids (H1 = drought tolerant, H2 = drought sensitive) was investigated in this study. Two field experiments were conducted during 2010 and 2011 under randomized complete block design with split split-plot arrangements and three replications of each treatment...
May 8, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29736557/the-seamless-integration-of-three-dimensional-rotational-angiography-images-into-electroanatomical-mapping-systems-to-guide-catheter-ablation-of-atrial-fibrillation
#17
Satoshi Fujita, Eitaro Fujii, Yoshihiko Kagawa, Katsuhiro Inoue, Tsuyoshi Yamada, Masaaki Ito
It is important to visually confirm radiofrequency ablation lesions during atrial fibrillation (AF) ablation for procedural efficiency, which requires the integration of a three-dimensional (3D) left atrial image reconstructed from computed tomography (CT) or a magnetic resonance imaging. However, an EP Navigator allows seamless integration of 3D anatomy obtained through 3D rotational angiography (3D-ATG) into an electroanatomical mapping system. We hypothesized that 3D-ATG can be used during AF ablation while significantly reducing the effective dose (ED) and without compromising image morphology compared to a 3D-CT image...
May 7, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29733054/an-application-study-of-low-dose-computed-tomography-perfusion-imaging-ldctpi-in-breast-cancer-and-breast-fibroadenoma
#18
You-Gen Cheng, Zong-Qiong Sun, Hong-Xia Zhang, Guo-Qun Mao
PURPOSE: To explore the characteristics of breast cancer and breast fibroadenoma using low-dose computed tomography perfusion imaging (LDCTPI) including specific perfusion parameter values, and seek the potential clinical applications in cancer prognosis assessment. MATERIALS AND METHODS: Fifty patients including 30 diagnosed with breast cancer and 20 with breast fibroadenoma, as well as 15 control subjects with normal breasts were studied prospectively using LDCTPI examinations...
May 3, 2018: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29732947/pulmonary-hypofunction-due-to-calcium-carbonate-nanomaterial-exposure-in-occupational-workers-a-cross-sectional-study
#19
Guoliang Li, Lihong Liang, Jingchao Yang, Lihai Zeng, Zhiwei Xie, Yizhou Zhong, Xiaolin Ruan, Ming Dong, Zhanhong Yang, Guanchao Lai, Weixin Huang, Aichu Yang, Jiabing Chen, Banghua Wu, Huaming Xu, Dezhi Meng, Shijie Hu, Lihua Xia, Xingfen Yang, Laiyu Li, Sahoko Ichihara, Gaku Ichihara, Hanlin Huang, Zhenlie Huang
Calcium carbonate nanomaterials (nano-CaCO3 ) are widely used in both manufacturing and consumer products, but their potential health hazards remain unclear. The objective of this study was to survey workplace exposure levels and health effects of workers exposed to nano-CaCO3 . Personal and area sampling, as well as real-time and dust monitoring, were performed to characterize mass exposure, particle size distribution, and particle number exposure. A total of 56 workers (28 exposed workers and 28 unexposed controls) were studied in a cross-sectional study...
May 6, 2018: Nanotoxicology
https://www.readbyqxmd.com/read/29723053/grafting-of-watermelon-citrullus-lanatus-cv-mahbubi-onto-different-squash-rootstocks-as-a-means-to-minimize-cadmium-toxicity
#20
Siamak Shirani Bidabadi, Reza Abolghasemi, Si-Jun Zheng
To test the possibility that using appropriate rootstocks could improve the tolerance of watermelon to cadmium (Cd) toxicity, a greenhouse experiment was conducted to determine growth and antioxidant activities of watermelons, either nongrafted or grafted onto summer squash and winter squash. We provided nutrient solutions having four levels (0, 50, 100, and 200 μM) of cadmium to treat the plants. Shoot and root biomass reduction were significantly lower in summer squash rootstock-grafted watermelon than winter squash rootstock-grafted and nongrafted watermelons...
June 7, 2018: International Journal of Phytoremediation
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