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https://www.readbyqxmd.com/read/27905183/mini-c-arm-faster-cheaper-safer
#1
Tom J Gieroba, Nicole Williams, Georgia Antoniou, Peter J Cundy
BACKGROUND: Mini C-arm image intensifiers (IIs) are promoted to permit lower radiation dose than traditional IIs with a lower purchase price and without the need for a radiographer, saving time. In real-world usage, radiation dose is not always lower. METHODS: A retrospective review of prospectively collected data for 620 children undergoing forearm fracture reduction in theatre was undertaken. Imaging was performed with the Fluoroscan mini C-arm or a comparison traditional II...
November 30, 2016: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/27898857/vitamin-e-plasma-kinetics-in-swine-show-low-bioavailability-and-short-half-life-of-%C3%AE-tocopheryl-acetate
#2
T A T G van Kempen, M H Reijersen, C de Bruijn, S De Smet, J Michiels, M G Traber, C Lauridsen
Vitamin E is important for animal production because of its effects on health and product quality, but the amount and form required remains controversial. Our objective was to quantify the absolute bioavailability of oral -α-tocopheryl acetate (α-TAc) in swine (22 ± 1 kg and 8 wk old, fitted with jugular catheters) adapted to a diet supplemented with 75 mg/kg -α-TAc; 75 mg/kg was chosen because this level represents the nonweighted average inclusion level in piglet diets across Western key swine-producing countries...
October 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27894729/effect-of-diagnostic-cone-beam-computed-tomography-protocols-on-image-quality-patient-dose-and-lesion-detection
#3
Jijo Paul, Annamma Chacko, Paola Saccomandi, Thomas J Vogl, Nour-Eldin A Nour-Eldin
OBJECTIVE: To evaluate the effect of cone-beam computed tomography (CBCT) image acquisition protocols on image quality, lesion detection, delineation, and patient dose. METHODS: 100-patients and a CTDI phantom combined with an electron density phantom were examined using four different CBCT-image acquisition protocols during image-guided transarterial chemoembolization (TACE). Protocol-1 (time: 6s, tube rotation: 360°), protocol-2 (5s, 300°), protocol-3 (4s, 240°) and protocol-4 (3s, 180°) were used...
November 25, 2016: Physica Medica: PM
https://www.readbyqxmd.com/read/27893455/patient-radiation-doses-in-paediatric-interventional-cardiology-procedures-a-review
#4
R W Harbron, S Dreuil, M-O Bernier, M S Pearce, I Thierry-Chef, C-L Chapple, H Baysson
A large number of investigations into the radiation doses from x-ray guided interventional cardiology procedures in children have been carried out in recent years. A review was conducted of these studies, gathering data on kerma area product (P KA), fluoroscopic screening time (FT), air kerma, and estimates of effective dose and organ doses. The majority of studies focus on P KA and FT with no estimation of dose to the patient. A greater than ten-fold variation in average P KA was found between different studies, even where data were stratified by patient age or weight...
November 28, 2016: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/27892721/social-aspects-in-additive-manufacturing-of-pharmaceutical-products
#5
Johanna Lind, Sofia Kälvemark Sporrong, Susanne Kaae, Jukka Rantanen, Natalja Genina
Additive manufacturing (AM) techniques, such as drug printing, represent a new engineering approach that can implement the concept of personalized medicine via on-demand manufacturing of dosage forms with individually adjusted doses. Implementation of AM principles, such as pharmacoprinting, will challenge the entire drug distribution chain and affect the society at different levels. Areas covered: This work summarizes the concept of personalized medicine and gives an overview of possibilities for monitoring patients' health...
November 28, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27889229/brown-propolis-attenuates-cerebral-ischemia-induced-oxidative-damage-via-affecting-antioxidant-enzyme-system-in-mice
#6
Gholamreza Bazmandegan, Mohammad Taher Boroushaki, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Allahtavakoli
Oxidative stress plays a critical role in ischemic brain injury. Superoxide dismutase (SOD) and glutathione peroxidase (GPx) are the enzymes underlying the endogenous antioxidant mechanisms affected by stroke and are considered as oxidative stress biomarkers. Brown propolis (BP) is a bioactive natural product with a set of biological activities that in turn may differ depending on the area from which the substance is originated. The aim of this study was to investigate the effect of water-extracted brown propolis (WEBPs), from two regions of Iran, against cerebral ischemia-induced oxidative injury in a mouse model of stroke...
November 23, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27885351/coronary-angiography-safety-between-transradial-and-transfemoral-access
#7
Santosh Kumar Sinha, Vikas Mishra, Nasar Afdaali, Mukesh Jitendra Jha, Ashutosh Kumar, Mohammad Asif, Ramesh Thakur, Chandra Mohan Varma
Background and Aim. The aim of study was to evaluate safety, feasibility, and procedural variables of transradial approach compared with transfemoral approach in a standard population of patients undergoing coronary catheterization as one of the major criticisms of the transradial approach is that it takes longer overall procedure and fluoroscopy time, thereby causing more radiation exposure. Method. Between January 2015 and December 2015, a total of 1,997 patients in LPS Institute of Cardiology, GSVM Medical College, Kanpur, UP, India, undergoing coronary catheterization were randomly assigned to the transradial or transfemoral approach...
2016: Cardiology Research and Practice
https://www.readbyqxmd.com/read/27885088/survey-of-effective-doses-to-patients-undergoing-contrast-based-x-ray-fluoroscopy-procedures-in-tanzania
#8
J E Ngaile, P K Msaki, R R Kazema
The aim of this study was to assess the radiation burden imparted to patients from contrast-based X-ray fluoroscopy procedures in Tanzania. The effective doses (EDs) to patients from five contrast-based fluoroscopy procedures were obtained from four hospitals. The ED was estimated using the knowledge of the patient characteristics, patient-related exposure parameters, measurements of air kerma area product and PCXCM software. The median EDs for the barium swallow (BS), barium meal (BM), barium enema (BE), hysterosalpingography (HSG) and retrograde urethrography (RUG) were 0...
November 24, 2016: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/27884716/therapeutic-effects-of-traditionalchinesemedicineniubeixiaohe-in-mouse-tuberculosis-models
#9
Yan Liang, Xiaomei Wang, Jinying Song, Lan Wang, Dan Chen, Yourong Yang, Xuejuan Bai, Jie Wang, Yingchang Shi, Shibing Chen, Jun Liu, Cunwei Yang, Huafeng Luo, Guangling Liu, Xueqiong Wu
ETHNOPHARMACOLOGICAL RELEVANCE: The traditional Chinese medicine Niubeixiaohe (NBXH) is an effective anti-tuberculosis prescription, which is made up of Bulbus Fritillariae Cirrhosae, Rhizoma Bletillae, Radix Platycodonis, Fructus Arctii, Herba Houttuyniae and Glutinous rice. In this study, NBXH powder (I) and three kinds of NBXH extracts (II, III, and IV) were prepared. The water decoction of NBXH had been used to treat TB in clinic sixteen years suggested that it was effective to treat TB...
November 21, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27878626/reducing-fluoroscopic-radiation-exposure-during-endomyocardial-biopsy-in-pediatric-transplant-recipients
#10
Jeffrey G Gossett, Christina L Sammet, Anya Agrawal, Karen Rychlik, David F Wax
Endomyocardial biopsy (EMB) with fluoroscopy is used for rejection surveillance in pediatric heart transplantation. Lowering frame rate may reduce radiation, but decreases temporal resolution and image quality. We undertook a quality initiative reducing frame rate from 10 frames per second (FPS) to 5 FPS. To assess whether lowering frame rate can reduce radiation exposure without compromising safety, data on EMBs from 9/2009 to 4/2013 without angiography or intervention were reviewed. Effective dose was calculated from dose area product (DAP) and fluoroscopy time...
November 23, 2016: Pediatric Cardiology
https://www.readbyqxmd.com/read/27876900/the-common-zoonotic-protozoal-diseases-causing-abortion
#11
REVIEW
Raafat Mohamed Shaapan
Toxoplasmosis, neosporosis, sarcosporidiosis (sarcocystosis) and trypanosomiasis are the common zoonotic protozoal diseases causing abortion which caused by single-celled protozoan parasites; Toxoplasma gondii, Neospora caninum, Sarcocystis spp and Trypanosoma evansi, respectively. Toxoplasmosis is generally considered the most important disease that causing abortion of both pregnant women and different female animals throughout the world, about third of human being population had antibodies against T. gondii...
December 2016: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/27863695/analysis-of-a-low-dose-protocol-to-reduce-patient-radiation-exposure-during-percutaneous-coronary-interventions
#12
Davide Maccagni, Cosmo Godino, Azeem Latib, Lorenzo Azzalini, Vittorio Pazzanese, Alaide Chieffo, Alberto Margonato, Antonio Colombo
The cardiac catheterization laboratory is an important source of radiation for patients and operators and it is good practice to limit exposure as much as possible. The purpose of this study was to evaluate the effectiveness and impact of a radiological low dose protocol (LDP) in terms of reduction in patient radiation exposure during percutaneous coronary interventions (PCIs). From November 2014 to October 2015, 906 consecutive patients who underwent PCI were evaluated. Of these, 571 patients (63%) were treated with the standard dose protocol (SDP) of 15 frames per second for cine acquisition and standard settings for fluoroscopy, and 335 patients (37%) with the LDP of 7...
October 8, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27855443/in-utero-exposure-to-radiation-and-haematological-malignancies-pooled-analysis-of-southern-urals-cohorts
#13
Joachim Schüz, Isabelle Deltour, Lyudmila Y Krestinina, Yulia V Tsareva, Evgenia I Tolstykh, Mikhail E Sokolnikov, Alexander V Akleyev
BACKGROUND: It is scientifically uncertain whether in utero exposure to low-dose ionising radiation increases the lifetime risk of haematological malignancies. METHODS: We pooled two cohorts from the Southern Urals comprising offspring of female workers of a large nuclear facility (the Mayak Production Association) and of women living in areas along the Techa River contaminated by nuclear accidents/waste from the same facility, with detailed dosimetry. RESULTS: The combined cohort totalled 19 536 subjects with 700 504 person-years at risk over the period of incidence follow-up, and slightly more over the period of mortality follow-up, yielding 58 incident cases and 36 deaths up to age 61 years...
November 17, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27825575/decreased-patient-exposure-to-ionizing-radiation-during-interventional-rheumatology-procedures-after-optimization-of-protection
#14
Céline Cozic, Fabien Audran, Christophe Blanchard, Christophe David, Vincent Andre, Michel Caulier, Stéphane Varin, Gilles Tanguy, Jérôme Dimet, Grégoire Cormier
OBJECTIVES: To decrease radiation exposure of patients undergoing interventional rheumatology procedures, without adversely affecting quality of care. METHODS: The radiation dose received, assessed by the dose-area product (DAP), was measured during 283 intraarticular injections performed under fluoroscopic guidance between May and July 2013. Then, three steps were taken to decrease patients' radiation exposure: a copper filter was added, the anti-scatter grid was removed, and exposure cell sensitivity was set at the highest value...
November 4, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27817811/a-multicenter-randomized-double-blind-dose-ranging-study-of-glycopyrrolate-formoterol-fumarate-fixed-dose-combination-metered-dose-inhaler-compared-to-the-monocomponents-and-open-label-tiotropium-dry-powder-inhaler-in-patients-with-moderate-to-severe-copd
#15
Donald P Tashkin, Fernando J Martinez, Roberto Rodriguez-Roisin, Charles Fogarty, Mark Gotfried, Michael Denenberg, Gregory Gottschlich, James F Donohue, Chad Orevillo, Patrick Darken, Earl St Rose, Shannon Strom, Tracy Fischer, Michael Golden, Colin Reisner
BACKGROUND: This study formed part of the dose selection for a glycopyrrolate (GP)/formoterol fumarate (FF) fixed-dose combination formulated using novel Co-Suspension™ Delivery Technology and delivered via a metered dose inhaler (GFF MDI). The study aimed to confirm the optimal dose of GP to formulate with FF 9.6 μg in the fixed-dose combination product, GFF MDI. METHODS: This multicenter, randomized, double-blind, chronic-dosing, balanced incomplete block, crossover study (NCT01587079) compared five doses of GFF MDI (18/9...
November 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27807948/procedural-resources-utilization-and-clinical-outcomes-with-bioresorbable-everolimus-eluting-scaffolds-and-pt-cr-everolimus-eluting-stent-with-resorbable-abluminal-polymer-in-clinical-practice-a-randomized-trial
#16
Jose M de la Torre Hernandez, Tamara Garcia Camarero, Dae-Hyun Lee, Fermin Sainz Laso, Gabriela Veiga Fernandez, Tania Pino, Silvia Rubio, Pablo Legarra, Jorge R Valdivia, Javier Zueco Gil
OBJECTIVES: We sought to compare the procedural implications of using bioresorbable everolimus-eluting scaffolds (BVS) and Pt-Cr everolimus-eluting stent with abluminal bioabsorbable polymer (Synergy). BACKGROUND: There are important differences in the respective platforms, which could impact on procedural performance, complications and outcomes. METHODS: A prospective, randomized single center study including consecutive patients in stable clinical condition and with lesions amenable to be treated with BVS according to predefined criteria...
November 3, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/27802899/nanocrystalline-cerium-dioxide-efficacy-for-prophylaxis-of-erosive-and-ulcerative-lesions-in-the-gastric-mucosa-of-rats-induced-by-stress
#17
Dmytro Golyshkin, Nazarii Kobyliak, Oleksandr Virchenko, Tetyana Falalyeyeva, Tetyana Beregova, Lyudmyla Ostapchenko, Martin Caprnda, Lubomir Skladany, Radka Opatrilova, Luis Rodrigo, Peter Kruzliak, Alexandr Shcherbokov, Mykola Spivak
In our previous works, the important therapeutic properties of nanocrystalline cerium dioxide such as strong antioxidant ability, prebiotical and antibiotic activity were shown. Such properties were obtained due to stabilization of nanoparticles with precise size 3-7nm. Such modification of nanocrystalline cerium dioxide has contributed to its remarkable efficacy and low toxicity. We have carried out the investigation of toxicity of the nanodrug and revealed that in the condition of the acute toxicity test, LD 50 was 2000mg/kg when it was administered per os...
October 29, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27801658/radiation-exposure-and-contrast-agent-reduction-during-transcatheter-aortic-valve-implantation-an-ongoing-experience
#18
Davide Maccagni, Cosmo Godino, Azeem Latib, Morena Mancin, Alaide Chieffo, Alberto Margonato, Antonio Colombo
OBJECTIVES: To determine the patient radiation exposure and contrast agent variation during transcatheter aortic valve implantation (TAVI) procedures resulting from technological improvements. METHODS: TAVI procedures from January 2008 to July 2015 were analyzed in three different time periods: 1st period, when the angiography was equipped with an image intensifier technology; 2nd period, starting with the installation of a new angiography system with flat-panel detector (FPD) technology; and 3rd period, starting with the systematic use of preprocedural multidetector computed tomography (MDCT) to individualize optimal fluoroscopic projections for the aortic prosthesis implantation...
November 2016: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/27797280/north-american-ginseng-panax-quinquefolius-suppresses-%C3%AE-adrenergic-dependent-signalling-hypertrophy-and-cardiac-dysfunction
#19
Xilan Tang, Xiaohong Tracey Gan, Venkatesh Rajapurohitam, Cathy Xiaoling Huang, Jenny Xue, Edmund M K Lui, Morris Karmazyn
There is increasing evidence for a beneficial effect of ginseng on cardiac pathology. Here, we determined whether North American ginseng can modulate the deleterious effects of the β-adrenoceptor agonist isoproterenol on cardiac hypertrophy and function using in vitro and in vivo approaches. Isoproterenol was administered for 2 weeks at either 25 mg/kg per day or 50 mg/kg per day (ISO25 or ISO50) via a subcutaneously implanted osmotic mini-pump to either control rats or those receiving ginseng (0.9 g/L in the drinking water ad libitum)...
December 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27797279/investigation-of-the-bioequivalence-of-two-lansoprazole-formulations-in-healthy-chinese-volunteers-after-a-single-oral-administration
#20
Yuhai Bian, Ming Zhong
The objective of this study was to compare two lansoprazole products (the reference brand enteric-coated capsules and the test generic enteric-coated tablets), and the key pharmacokinetic (PK) parameters for both formulations and their metabolites were assessed. The study used an open-label, randomized two-period crossover design with an 8-day washout period between doses in 24 healthy subjects under fasting conditions. The concentration of lansoprazole and its two metabolites was determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS) method...
October 31, 2016: Artificial Cells, Nanomedicine, and Biotechnology
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