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https://www.readbyqxmd.com/read/29160230/paediatric-interventional-cardiology-in-costa-rica-diagnostic-reference-levels-and-estimation-of-population-dose
#1
Carlos Ubeda, Eliseo Vano, Luisa Salazar, Viviana Retana, Freddys Santos, Rafael Gutierrez, Carlos Manterola
The goal of the present study is to propose a set of national diagnostic reference levels (DRLs) for paediatric interventional cardiology (IC) procedures classified by age and weight in Costa Rica and to estimate the collective dose to the paediatric population deriving from these intervention practices. The data collection period was from May 2016 to May 2017. National DRLs were set as the third quartile of patient dose data distributions for kerma area-product (KAP) values. A sample of 154 paediatric IC procedures (collected in the national paediatric hospital with a single x-ray system) was used and divided into four age ranges and five weight ranges...
November 21, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29159034/hamman-rich-syndrome
#2
Arshiya Mastan, Nilaani Murugesu, Adil Hasnain, Terry O'Shaughnessy, Vladimir Macavei
INTRODUCTION: Acute interstitial pneumonia is a rare but important diagnosis, associated with a high mortality rate and important to identify early. CASE PRESENTATION: A 76 year-old individual presented to hospital with a two-week history of shortness of breath, fevers and a non-productive cough. Treatment initially was for lower respiratory tract infection but returned to hospital three days later as her shortness of breath and peripheral oedema was worsening despite diuretic treatment...
2018: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/29155084/anti-inflammatory-antinociceptive-and-antioxidant-properties-of-schinopsis-brasiliensis-bark
#3
Clisiane Carla de Souza Santos, Carolina Carvalho Guilhon, Daniela Sales Alviano Moreno, Celuta Sales Alviano, Charles Dos Santos Estevam, Arie Fitzgerald Brank, Patricia Dias Fernandes
ETHNOPHARMACOLOGICAL RELEVANCE: Schinopsis brasiliensis is a native plant from Brazil, popularly used in folk medicine to relieve pain and treat inflammation. This study evaluated the antinociceptive and anti-inflammatory activities and antioxidant properties of the hydroethanol extract (HEE) and ethyl acetate fraction (EAF) obtained from S. brasiliensis bark. MATERIALS AND METHODS: The HEE and EAF of S. brasiliensis bark (10, 30 and 100mg/kg, p.o.) were evaluated using models of analgaesia (formalin-induced licking and hot -plate models) or inflammation (licking response by formalin-induced and carrageenan-induced cell migration into the subcutaneous air pouch)...
November 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29153441/complex-endovascular-repair-of-postdissection-arch-and-thoracoabdominal-aneurysms
#4
Rafaëlle Spear, Adrien Hertault, Katrien Van Calster, Nicla Settembre, Matthieu Delloye, Richard Azzaoui, Jonathan Sobocinski, Dominique Fabre, Mark Tyrrell, Stéphan Haulon
OBJECTIVE: We report our experience of the treatment of postdissection arch aneurysms and thoracoabdominal aortic aneurysms (TAAAs) by endovascular repair using fenestrated and branched endografts. METHODS: This study includes all patients presenting with chronic postdissection aneurysms >55 mm in diameter deemed unfit for open surgery and treated by complex endografting between October 2011 and April 2017. Where appropriate, staged management strategies including left subclavian artery revascularization, thoracic endografting, dissection flap fenestration, and tear enlargement were performed before the complex endovascular repair...
November 15, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29153361/noise-reduction-angiographic-imaging-technology-reduces-radiation-dose-during-bronchial-artery-embolization
#5
C Spink, M Avanesov, T Schmidt, M Grass, G Schoen, G Adam, A Koops, H Ittrich, P Bannas
PURPOSE: Comparison of radiation doses in patients undergoing angiographic bronchial artery embolization (BAE) before and after a noise reduction imaging technology upgrade. METHODS: We performed a retrospective study of 70 patients undergoing BAE. Procedures were performed before (n=32) and after (n=38) the technology upgrade containing additional filters and improved image-processing. Cumulative air kerma (AK), cumulative dose area product (DAP), number of exposure frames, total fluoroscopy time and amount of contrast agent were recorded...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29149889/electronic-cigarette-vapor-alters-the-lateral-structure-but-not-tensiometric-properties-of-calf-lung-surfactant
#6
Rebecca J Przybyla, Jason Wright, Rajan Parthiban, Saeed Nazemidashtarjandi, Savas Kaya, Amir M Farnoud
BACKGROUND: Despite their growing popularity, the potential respiratory toxicity of electronic cigarettes (e-cigarettes) remains largely unknown. One potential aspect of e-cigarette toxicity is the effect of e-cigarette vapor on lung surfactant function. Lung surfactant is a mixture of lipids and proteins that lines the alveolar region. The surfactant layer reduces the surface tension of the alveolar fluid, thereby playing a crucial role in lung stability. Due to their small size, particulates in e-cigarette vapor can penetrate the deep lungs and come into contact with the lung surfactant...
November 17, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29142346/conjugation-of-antibodies-with-radiogold-nanoparticles-as-an-effector-targeting-agents-in-radiobioconjugate-cancer-therapy-optimized-labeling-and-biodistribution-results
#7
Pankaj Garg, Daya Kishore Hazra
Purpose of the Study: Drug accessibility to the tumor cells is an important area of concern with an anticipation of increasing the efficacy of the drug to be delivered to a specific site. The biogenesis of gold nanoparticles using plant-mediated phytochemical extracts and their possible linkage to cancer antibodies with an aim at delivering the conjugate specifically to the tumor-associated antigen is the basic objective of the research. Materials and Methodology: Radiolabeling of antibodies with gold nanoparticles was carried out by a protocol, and the labeling extent of antibodies was compared with that of a radiogold solution to ordinary particulate size (AuNO-Ab)...
October 2017: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/29140797/characterising-endourologist-learning-curve-during-percutaneous-nephrolithotomy-implications-on-occupational-dose-and-patients
#8
Jacobo Guiu-Souto, Carlos Otero, Daniel A Pérez-Fentes, Carlos Fernández-Baltar, Juan Francisco Sánchez-Garcia, Camilo García-Freire, Miguel Pombar-Cameán, Juan Pardo-Montero
In this study we have characterised the learning curve for percutaneous nephrolithotomy procedures over 301 cases for six years. Different surrogate parameters of clinical expertise have been used, such as dose area product, total procedure time, fluoroscopy time and personal equivalent doses. In addition, two different endourologists have been monitored; one of whom had specific Radiation Protection training (ICRP 85). Eye lens dose was estimated from thermoluminescent dosimeters. Significant differences were observed between both endourologists, especially in the fluoroscopy time...
November 15, 2017: Journal of Radiological Protection: Official Journal of the Society for Radiological Protection
https://www.readbyqxmd.com/read/29140505/the-nrpi-multi-purpose-on-line-monitoring-station-for-measurement-of-natural-radioactivity-in-the-ambient-atmosphere-and-in-the-soil
#9
K Jílek, M Slezáková, A Fronka, T Prokop, L Neubauer
During years 2010-12 an automated, on-line and wireless outdoor measurement station of atmospheric radon, gamma dose rate and meteorological parameters was realised at the National Radiation Protection Institute (NRPI) in Prague. At the turn of the year 2013 an expansion of the existing station was completed. Under the project funded by the Czech Technological Agency a new updated station was established, additionally equipped with modules for measurement of atmospheric radon/thoron short-lived decay products, radon in water and soil and radon exhalation rate from soil...
November 13, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29138535/comparable-pharmacokinetics-and-pharmacodynamics-of-two-epoetin-alfa-formulations-eporon-%C3%A2-and-eprex-%C3%A2-following-a-single-subcutaneous-administration-in-healthy-male-volunteers
#10
Sumin Yoon, Su-Jin Rhee, Sun Ju Heo, Tae Young Oh, Seo Hyun Yoon, Joo-Youn Cho, SeungHwan Lee, Kyung-Sang Yu
Purpose: This study aimed to assess and compare the pharmacokinetic (PK) and pharmacodynamic (PD) properties following a single subcutaneous injection of epoetin alfa (Eporon(®)) with those of the comparator (Eprex(®)) in healthy male subjects. Subjects and methods: A randomized, double-blind, two-sequence, crossover study was conducted. Subjects were randomly assigned to receive a single dose, that is, 4,000 IU, of the test or comparator epoetin alfa. After 4 weeks, all subjects received the alternative formulation...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29135993/bioequivalence-between-innovator-and-generic-tacrolimus-in-liver-and-kidney-transplant-recipients-a-randomized-crossover-clinical-trial
#11
Rita R Alloway, Alexander A Vinks, Tsuyoshi Fukuda, Tomoyuki Mizuno, Eileen C King, Yuanshu Zou, Wenlei Jiang, E Steve Woodle, Simon Tremblay, Jelena Klawitter, Jost Klawitter, Uwe Christians
BACKGROUND: Although the generic drug approval process has a long-term successful track record, concerns remain for approval of narrow therapeutic index generic immunosuppressants, such as tacrolimus, in transplant recipients. Several professional transplant societies and publications have generated skepticism of the generic approval process. Three major areas of concern are that the pharmacokinetic properties of generic products and the innovator (that is, "brand") product in healthy volunteers may not reflect those in transplant recipients, bioequivalence between generic and innovator may not ensure bioequivalence between generics, and high-risk patients may have specific bioequivalence concerns...
November 2017: PLoS Medicine
https://www.readbyqxmd.com/read/29129528/educational-effects-of-radiation-reduction-during-fluoroscopic-examination-of-the-adult-gastrointestinal-tract
#12
Moon Hyung Choi, Seung Eun Jung, Soon Nam Oh, Jae Young Byun
RATIONALE AND OBJECTIVES: This study aimed to evaluate the effects of educating radiology residents and radiographers about radiation exposure on reduction of dose area product (DAP) and fluoroscopy time in diagnostic fluoroscopy of the gastrointestinal (GI) tract in adult patients. MATERIALS AND METHODS: In April 2015, we offered 1 hour of education to radiology residents and radiographers on how to reduce radiation doses during fluoroscopic examinations. Fluoroscopic examinations of the GI tracts of adult patients performed from June 2014 to February 2016 were evaluated...
November 9, 2017: Academic Radiology
https://www.readbyqxmd.com/read/29124707/uv-disinfection-of-wastewater-and-combined-sewer-overflows
#13
John Gibson, Jennifer Drake, Bryan Karney
Municipal wastewater contains bacteria, viruses, and other pathogens that adversely affect the environment, human health, and economic activity. One way to mitigate these effects is a final disinfection step using ultraviolet light (UVL). The advantages of UVL disinfection, when compared to the more traditional chlorine, include no chlorinated by-products, no chemical residual, and relatively compact size. The design of most UV reactors is complex. It involves lamp selection, power supply design, optics, and hydraulics...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29122421/evaluating-strategies-for-reducing-scattered-radiation-in-fixed-imaging-hybrid-operating-suites
#14
Claire Miller, Daniel Kendrick, Andrew Shevitz, Ann Kim, Henry Baele, David Jordan, Vikram S Kashyap
OBJECTIVE: High-resolution fixed C-arm fluoroscopic systems allow high-quality endovascular imaging but come at a cost of greater scatter radiation generation and increased occupational exposure for surgeons. The purpose of this study was to evaluate the efficacy of two methods in reducing scattered radiation exposure. METHODS: There were 164 endovascular cases analyzed in three phases. In phase 1 (P1), baseline radiation exposure was calculated. In phase 2 (P2), staff used real-time radiation dose monitoring (dosimetry badges [RaySafe; Unfors, Hopkinton, Mass])...
November 6, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29121900/synergistic-gastroprotective-activity-of-methanolic-extract-of-a-mixture-of-melastoma-malabathricum-and-muntingia-calabura-leaves-in-rats
#15
Siti Zawanah Halim, Zainul Amiruddin Zakaria, Maizatul Hasyima Omar, Norhafizah Mohtarrudin, Ikarastika Rahayu Abdul Wahab, Muhammad Nazrul Hakim Abdullah
BACKGROUND: Melastoma malabathricum L. (family Melastomaceae; MM) and Muntingia calabura L. (family Elaeocarpaceae; MC) have been separately reported to possess gastroprotective activity. In an attempt to develop a pharmaceutical product with antiulcer potential, the synergistic gastroprotective activity of methanolic extract of a mixture of MM and MC (MMMC) at various ratios was evaluated in rat models. METHODS: Rats were pre-treated orally with 2% Tween 80 (vehicle), 100 mg/kg ranitidine (reference drug) or MMMC (ratios of 1:1, 1:3 and 3:1 (v/v); doses of 15, 150 or 300 mg/kg) and then subjected to the ethanol-induced gastric ulcer or pyloric ligation assays...
November 9, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29118787/radiation-exposure-during-neurointerventional-procedures-in-modern-biplane-angiographic-systems-a-single-site-experience
#16
Ameer E Hassan, Sophie Amelot
Background and Purpose: Per the ALARA principle, reducing the dose delivered to both patients and staff must be a priority for endovascular therapists, who should monitor their own practice. We evaluated patient exposure to radiation during common neurointerventions performed with a recent flat-panel detector angiographic system and compared our results with those of recently published studies. Methods: All consecutive patients who underwent a diagnostic cerebral angiography or intervention on 2 modern flat-panel detector angiographic biplane systems (Innova IGS 630, GE Healthcare, Chalfont St Giles, UK) from February to November 2015 were retrospectively analyzed...
October 2017: Interventional Neurology
https://www.readbyqxmd.com/read/29117131/natural-deep-eutectic-solvents-nades-to-enhance-berberine-absorption-an-in-vivo-pharmacokinetic-study
#17
Stefania Sut, Marta Faggian, Valeria Baldan, Gabriele Poloniato, Ignazio Castagliuolo, Iztok Grabnar, Beatrice Perissutti, Paola Brun, Filippo Maggi, Dario Voinovich, Gregorio Peron, Stefano Dall'Acqua
In the present study results related to the in vivo administration of Natural Deep Eutectic Solvents (NADES)-solubilized berberine are reported for the first time. NADES are mixtures of small natural compounds having a melting point significantly lower than that of any individual component. Such solvents have gained much attention of the scientific community in the green chemistry area, being considered useful alternatives to common organic solvents. NADES can be used also as administration vehicles, and this can be attractive for nutraceutical products when eutectics are formed with food grade ingredients...
November 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29110595/the-impact-of-ultraviolet-radiation-on-barrier-function-in-human-skin-molecular-mechanisms-and-topical-therapeutics
#18
Abdulaziz Alhasaniah, Michael J Sherratt, Catherine O'Neill
A competent epidermal barrier is crucial for terrestrial mammals. This barrier must keep in water and prevent entry of noxious stimuli. Most importantly, the epidermis must also be a barrier to ultraviolet radiation (UVR) from the sunlight. Currently, the effects of ultraviolet radiation on epidermal barrier function are poorly understood. However, studies in mice and more limited work in humans suggest that the epidermal barrier becomes more permeable, as measured by increased transepidermal water loss, in response UVR, at doses sufficiently high to induce erythema...
November 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29104180/safety-and-feasibility-of-a-low-frame-rate-protocol-for-percutaneous-coronary-intervention-to-chronic-total-occlusions-preliminary-experience
#19
Lei Ge, Xin Zhong, Jianying Ma, Bing Fan, Hao Lu, Juying Qian, Junbo Ge
AIMS: The present study aimed to evaluate the safety and feasibility of a low frame rate protocol for chronic total occlusions (CTOs)-percutaneous coronary intervention (PCI). METHODS AND RESULTS: 192 consecutive patients who underwent CTO-PCI following the low frame rate protocol were analyzed. The low frame rate protocol adopted reduced frame rates and addition of copper and aluminum filter. Procedural outcomes, radiation dose and in-hospital outcomes were ascertained...
November 7, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29102573/radiation-exposure-among-scrub-technologists-and-nurse-circulators-during-cardiac-catheterization-the-impact-of-accessory-lead-shields
#20
Ryan D Madder, Andrew LaCombe, Stacie VanOosterhout, Abbey Mulder, Matthew Elmore, Jessica L Parker, Mark E Jacoby, David Wohns
OBJECTIVES: This study was performed to determine if the use of an accessory lead shield is associated with a reduction in radiation exposure among staff members during cardiac catheterization. BACKGROUND: Accessory lead shields that protect physicians from scatter radiation are standard in many catheterization laboratories, yet similar shielding for staff members is not commonplace. METHODS: Real-time radiation exposure data were prospectively collected among nurses and technologists during 764 consecutive catheterizations...
October 25, 2017: JACC. Cardiovascular Interventions
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