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https://www.readbyqxmd.com/read/29328898/idiopathic-hypercalciuria-can-we-prevent-stones-and-protect-bones
#1
REVIEW
Laura E Ryan, Steven W Ing
Idiopathic hypercalciuria increases the risk of urinary stones and osteoporosis. The aim of this review is to delineate our current understanding of idiopathic hypercalciuria in the context of bone health, specifically its definition, causes, epidemiology, laboratory evaluation, and potential treatments.
January 2018: Cleveland Clinic Journal of Medicine
https://www.readbyqxmd.com/read/29285942/-non-alcoholic-fatty-liver-disease-as-a-component-of-the-metabolic-syndrome-and-its-causal-correlations-with-other-extrahepatic-diseases
#2
Tamás Halmos, Ilona Suba
Non-alcoholic fatty liver disease is the most common non-infectious chronic liver-disease in our age, and is a spectrum of all the diseases associated with increased fat accumulation in the hepatocytes. Its development is promoted by sedentary life-style, over-feeding, and certain genetic predisposition. Prevalence in the adult population, even in Hungary is ~30%. In a part of cases, this disease may pass into non-alcoholic steatohepatitis, later into fibrosis, rarely into primary hepatocellular cancer. Fatty liver is closely and bidirectionally related to the metabolic syndrome and type 2 diabetes, and nowadays there is a general consensus that fatty liver is the hepatic manifestation of the metabolic sycndrome...
December 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/29259852/epidemiology-diagnosis-and-treatment-of-wilson-s-disease
#3
REVIEW
Jing Liu, Jing Luan, Xiaoyan Zhou, Yazhou Cui, Jinxiang Han
Wilson's disease (WD) is an autosomal recessive disease caused by a mutation of the ATP7B gene, resulting in abnormal copper metabolism. The major clinical features of WD include liver disease, neurological disorders, K-F rings, and osteoporosis. The prevalence of WD in China is higher than that in Western countries. Early diagnosis and lifelong treatment will lead to better outcomes. Drugs such as sodium dimercaptosuccinate (Na-DMPS), Zn, and Gandou Decoction can be used to treat WD. Some studies have shown that the combination of traditional Chinese medicine and Western medicine is the best approach to treating WD...
November 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29234969/monoclonal-antibodies-for-treatment-of-eosinophilic-esophagitis
#4
REVIEW
Mahsa Eskian, MirHojjat Khorasanizadeh, Amal H Assa'ad, Nima Rezaei
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease of the esophagus affecting both children and adults, with debilitating and progressive symptoms. EoE has shown an explosive epidemiological rise in the past few decades. Many patients experience a poor level of disease control despite maximal use of available guideline-based therapies, which seriously hampers their quality of life. Diet restrictions and systemic and topical corticosteroids are the current mainstays of EoE therapy, but are associated with significant efficacy, treatment compliance, and safety issues such as oral or esophageal candidiasis, growth retardation, osteopenia, osteoporosis, glucose intolerance, and cataract formation...
December 12, 2017: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29197959/fractures-frequently-occur-in-older-cancer-patients-the-md-anderson-cancer-center-experience
#5
Beatrice J Edwards, Ming Sun, Xiaotao Zhang, Holly M Holmes, Juhee Song, Peter Khalil, Meghan Karuturi, Jay B Shah, Colin P Dinney, Robert F Gagel, Vicente Valero, Richard E Champlin, Debasish Tripathy, William A Murphy
PURPOSE AND INTRODUCTION: A growing number of cancer patients are older adults aged 65 years and older. Patients with cancer are at increased risk for developing osteoporosis, falls, and fractures. We sought to identify the incidence of fractures in older adults who underwent cancer care between January 2013 and December 2015. METHODS: A comprehensive geriatric assessment was performed, and bone densitometry was measured at baseline, with a 2-year follow-up. RESULTS: In this study, among 304 patients with gastrointestinal, urologic, breast, lung, and gynecologic cancers we evaluated, and who completed the bone density testing (n = 199), 80% had osteoporosis or low bone mass (osteopenia)...
December 2, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29195740/validation-of-fragility-fractures-in-primary-care-electronic-medical-records-a-population-based-study
#6
Daniel Martinez-Laguna, Alberto Soria-Castro, Cristina Carbonell-Abella, Pilar Orozco-López, Pilar Estrada-Laza, Xavier Nogues, Adolfo Díez-Perez, Daniel Prieto-Alhambra
PURPOSE: Electronic medical records databases use pre-specified lists of diagnostic codes to identify fractures. These codes, however, are not specific enough to disentangle traumatic from fragility-related fractures. We report on the proportion of fragility fractures identified in a random sample of coded fractures in SIDIAP. METHODS: Patients≥50 years old with any fracture recorded in 2012 (as per pre-specified ICD-10 codes) and alive at the time of recruitment were eligible for this retrospective observational study in 6 primary care centres contributing to the SIDIAP database (www...
November 28, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/29181200/epidemiology-of-c2-fractures-in-the-21st-century-a-national-registry-cohort-study-of-6-370-patients-from-1997-to-2014
#7
Anna-Lena Robinson, Claes Olerud, Yohan Robinson
Objective: C2 fractures are a common injury in the elderly population. Treatment is often complicated due to osteoporosis and patient comorbidity. This study aims to investigate the incidence and treatment trend of C2 fractures in Sweden. Methods: Patients with the principal and secondary diagnosis of fracture of the second vertebrae (ICD-10: S12.1) between 1997 and 2014 were identified in the Swedish National Patient Registry (NPR). Results: Between 1997 and 2014, 6,370 patients with a C2 fracture (51% male; age: 72 ± 18) were identified in the NPR...
2017: Advances in Orthopedics
https://www.readbyqxmd.com/read/29177024/epidemiology-of-fragility-fractures-and-fall-prevention-in-the-elderly-a-systematic-review-of-the-literature
#8
REVIEW
Takayuki Tsuda
Fragility fractures in the elderly is an ongoing concern for orthopaedic surgeons. A 50-year-old woman has a 40% chance of having a vertebral compression fracture in her lifetime. The incidence of vertebral fractures, reported to be more than 10 times higher than that of femoral fractures, is estimated as 1-1.5 million per year in Japan. Vertebral fractures often occur without a fall, whereas the majority of nonvertebral fractures are the consequence of falls; the site of the nonvertebral fracture appears to be dictated by the type of fall...
November 2017: Current Orthopaedic Practice
https://www.readbyqxmd.com/read/29168548/guidelines-for-the-diagnosis-and-management-of-osteoporosis-in-poland-update-2017
#9
Roman Lorenc, Piotr Głuszko, Edward Franek, Mirosław Jabłoński, Maciej Jaworski, Ewa Kalinka-Warzocha, Elzbieta Karczmarewicz, Tomasz Kostka, Krystyna Księzopolska-Orłowska, Ewa Marcinowska-Suchowierska, Waldemar Misiorowski, Andrzej Więcek
In the rapidly ageing society in Poland, osteoporosis is a growing epidemiological problem, and osteoporosis-related fractures are a cause of chronic disability and considerable increase of death risk. It turns out that 80 to 90% of patients suffering from osteoporosis, including osteoporosis accompanied by fractures, do not receive adequate pharmacotherapy. In this paper, a Guideline Working Group of experts from the Multidisciplinary Osteoporosis Forum update the existing Polish guidelines concerning the diagnosis and management of osteoporosis (last revised in 2013), taking account of the latest literature, availability and reimbursement of drugs, and current health care organisation...
2017: Endokrynologia Polska
https://www.readbyqxmd.com/read/29154830/understanding-mechanisms-to-promote-successful-aging-in-persons-living-with-hiv
#10
REVIEW
Gerome V Escota, Jane A O'Halloran, William G Powderly, Rachel M Presti
The mortality rate associated with HIV infection plummeted after the introduction of effective antiretroviral therapy pioneered two decades ago.As a result, HIV-infected people now have a life expectancy comparable to that of HIV-uninfected individuals. Despite this, increased rates of osteoporosis, chronic liver disease, and in particular cardiovascular disease have been reported among people living with HIV infection. With the aging HIV-infected population, the burden of these co-morbid illnesses may continue to accrue over time...
November 14, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29150162/distribution-of-clinical-risk-factors-for-fracture-in-a-brussels-cohort-of-postmenopausal-women-the-frisbee-study-and-comparison-with-other-major-cohort-studies
#11
S I Cappelle, I Ramon, C Dekelver, S Rozenberg, F Baleanu, R Karmali, M Rubinstein, M Tondeur, M Moreau, M Paesmans, P Bergmann, J-J Body
OBJECTIVES: The estimation of fracture risk using clinical risk factors (CRFs) is of primary concern in osteoporosis management, but only some risk factors have been thoroughly evaluated and incorporated in predictive models. We have launched a large prospective study, the 'Fracture Risk Brussels Epidemiological Enquiry' (FRISBEE), to develop a new predictive model for osteoporotic fractures. The aims of this report are to describe the methodology of the FRISBEE study and to compare the distribution of CRFs in our cohort with those reported in other large studies...
December 2017: Maturitas
https://www.readbyqxmd.com/read/29137199/epidemiology-of-bone-fracture-in-female-trauma-patients-based-on-risks-of-osteoporosis-assessed-using-the-osteoporosis-self-assessment-tool-for-asians-score
#12
Cheng-Shyuan Rau, Shao-Chun Wu, Pao-Jen Kuo, Yi-Chun Chen, Peng-Chen Chien, Hsiao-Yun Hsieh, Ching-Hua Hsieh
Background: Osteoporotic fractures are defined as low-impact fractures resulting from low-level trauma. However, the exclusion of high-level trauma fractures may result in underestimation of the contribution of osteoporosis to fractures. In this study, we aimed to investigate the fracture patterns of female trauma patients with various risks of osteoporosis based on the Osteoporosis Self-Assessment Tool for Asians (OSTA) score. Methods: According to the data retrieved from the Trauma Registry System of a Level I trauma center between 1 January 2009 and 31 December 2015, a total of 6707 patients aged ≥40 years and hospitalized for the treatment of traumatic bone fracture were categorized as high-risk (OSTA < -4, n = 1585), medium-risk (-1 ≥ OSTA ≥ -4, n = 1985), and low-risk (OSTA > -1, n = 3137) patients...
November 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29133976/bisphosphonates-atherosclerosis-and-vascular-calcification-update-and-systematic-review-of-clinical-studies
#13
REVIEW
Carla Caffarelli, Andrea Montagnani, Ranuccio Nuti, Stefano Gonnelli
Background: Epidemiologic and clinical data have suggested the existence of a biologic linkage between the bone system and the vascular system. Bisphosphonates (BPs) are effective inhibitors of bone resorption and are currently considered the drugs of choice for the prevention and treatment of osteoporosis and related fractures. Data from several publications have suggested that BPs may also be effective in reducing the atherosclerotic process and vascular calcification, but the results of these studies are contrasting...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29074833/-update-on-recent-progress-in-vitamin-d-research-vitamin-d-insufficiency-deficiency
#14
Ryo Okazaki
Serum 25(OH)D level reflects bodily vitamin D store. Recently published "Assessment criteria for vitamin D deficiency/insufficiency in Japan" defines vitamin D sufficiency as 25(OH)D level of 30 ng/mL or more, vitamin D insufficiency as that of 20 to 30 ng/mL, vitamin D deficiency as that of less than 20 ng/mL. The lower the serum 25(OH)D level is, the higher the risks are, of secondary hyperparathyroidism, low bone mineral density, fall, fracture, rickets/osteomalacia, and hypocalcemia, as well as lower response to anti-osteoporosis medications...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/29067572/age-and-gender-specific-epidemiology-treatment-patterns-and-economic-burden-of-osteoporosis-and-associated-fracture-in-taiwan-between-2009-and-2013
#15
Chen-Yu Wang, Shau-Huai Fu, Rong-Sen Yang, Li-Jiuan Shen, Fe-Lin Lin Wu, Fei-Yuan Hsiao
This nationwide study investigated the epidemiology, treatment patterns, and economic burden of osteoporosis and associated fracture in Taiwan. The treatment of osteoporosis is alarmingly suboptimal, considering the significantly increased economic burden of major osteoporotic fracture. Osteoporosis men received lesser anti-osteoporosis drugs but had higher incremental costs attributable to osteoporotic fractures. PURPOSE: This nationwide study investigated the epidemiology, treatment patterns, and economic burden of osteoporosis and associated fracture between 2009 and 2013 in Taiwan...
October 25, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/29058268/early-diagnosed-cerebrotendinous-xanthomatosis-patients-clinical-neuroradiological-characteristics-and-therapy-results-of-a-single-center-from-turkey
#16
Tanyel Zubarioglu, Ertugrul Kiykim, Gozde Yesil, Duhan Demircioglu, Mehmet Serif Cansever, Cengiz Yalcinkaya, Cigdem Aktuglu-Zeybek
Cerebrotendinous xanthomatosis (CTX) is a lipid storage disorder caused by defective sterol 27-hydroxylase activity. In spite of subtle clinical signs beginning from childhood, CTX is generally diagnosed lately. The aim of this study is to evaluate clinical, neuroradiological findings and therapy responses of pediatric CTX patients and raise awareness to early features of disease. Patients who were molecularly diagnosed as CTX before 18 years of age were included in study. Clinical, epidemiological, radiological and genotypic features of patients and chenodeoxycholic acid (CDCA) therapy responses were reviewed retrospectively...
October 22, 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/29044037/-review-of-epidemiology-of-fractures-in-the-icelandic-heart-association-cohort
#17
Gunnar Sigurdsson, Kristin Siggeirsdottir, Brynjolfur Y Jonsson, Brynjolfur Morgensen, Elías F Gudmundsson, Thor Aspelund, Vilmundur Gudnason
IIn recent years, scientific papers have been published in Osteoporosis International on the epidemiology of fractures in Iceland based on the Icelandic Heart Association cohort. We report the main results with emphasis on the major osteoporotic fractures (MOF), distal forearm, upper arm, clinical vertebral and hip. Those four types of fractures have been reported to cause about 90% of the total burden of all osteoporotic fractures. The incidence of those four fractures in the Icelandic Heart Association cohort have been used as the basis for the international fracture risk calculator "FRAX "in Iceland...
October 2017: Læknablađiđ
https://www.readbyqxmd.com/read/29027045/characteristics-of-patients-with-fragility-hip-fractures-in-the-northern-kyushu-district-in-japan-a-multicenter-prospective-registry-based-on-an-electronic-data-capture-system
#18
Akiko Oyamada, Yoshihiro Matsumoto, Yoshifumi Wakata, Atsushi Kimura, Ko Ikuta, Kuniyoshi Tsuchiya, Naohisa Tayama, Shinji Tomari, Hisaaki Miyahara, Takao Mae, Hirokazu Shiraishi, Taichi Saito, Takeshi Arizono, Kozo Kaji, Taro Mawatari, Masami Fujiwara, Riku Sakimura, Kunichika Shin, Kenichi Ninomiya, Kazutoshi Nakaie, Yasuaki Antoku, Shoji Tokunaga, Naoki Nakashima, Yukihide Iwamoto, Yasuharu Nakashima
Osteoporosis has become a worldwide public health problem, in part due to the fact that it increases the risk of fragility hip fractures (FHFs). The epidemiological assessment of FHFs is critical for their prevention; however, datasets for FHFs in Japan remain scarce. This was a multicenter, prospective, observational study in the northern district of Kyushu Island. Inclusion criteria were age > 60 years with a diagnosis of FHF and acquisition of clinical data by an electronic data capture system. Of 1294 registered patients, 1146 enrolled in the study...
October 12, 2017: Journal of Bone and Mineral Metabolism
https://www.readbyqxmd.com/read/29022168/vertebral-heights-and-ratios-are-not-only-race-specific-but-also-gender-and-region-specific-establishment-of-reference-values-for-mainland-chinese
#19
Lei Ning, Li-Jiang Song, Shun-Wu Fan, Xing Zhao, Yi-Lei Chen, Zhao-Zhi Li, Zi-Ang Hu
This study established gender-specific reference values in mainland Chinese (MC) and is important for quantitative morphometry for diagnosis and epidemiological study of osteoporotic vertebral compressive fracture. Comparisons of reference values among different racial populations are then performed to demonstrate the MC-specific characteristic. PURPOSE: Osteoporotic vertebral compressive fracture (OVCF) is a common complication of osteoporosis in the elder population. Clinical diagnosis and epidemiological study of OVCF often employ quantitative morphometry, which relies heavily on the comparison of patients' vertebral parameters to existing reference values derived from the normal population...
October 11, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28990503/effects-of-isolated-isoflavones-intake-on-health
#20
Antonella Smeriglio, Antonella Calderaro, Marcella Denaro, Giuseppina Laganà, Ersilia Bellocco
Isoflavones are naturally occurring flavonoids characterized by a structure able to exert non-steroidal estrogen-like activity on human cells. The atypical linkage between the rings B and C remarkable influences these potentialities and confers them specific applications, along with the biochemical modification such as acetylation and malonylation. Plants belonging to Leguminosae family are the most abundant and rich sources for human organism, where, after their ingestion and metabolization, they show positive health effects on several diseases, especially in the prevention of coronary heart and neurological diseases, hormone-related cancers, osteoporosis, and postmenopausal symptoms...
October 6, 2017: Current Medicinal Chemistry
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