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osteoporosis epidemiology

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https://www.readbyqxmd.com/read/27935995/into-the-bowels-of-depression-unravelling-medical-symptoms-associated-with-depression-by-applying-machine-learning-techniques-to-a-community-based-population-sample
#1
Joanna F Dipnall, Julie A Pasco, Michael Berk, Lana J Williams, Seetal Dodd, Felice N Jacka, Denny Meyer
BACKGROUND: Depression is commonly comorbid with many other somatic diseases and symptoms. Identification of individuals in clusters with comorbid symptoms may reveal new pathophysiological mechanisms and treatment targets. The aim of this research was to combine machine-learning (ML) algorithms with traditional regression techniques by utilising self-reported medical symptoms to identify and describe clusters of individuals with increased rates of depression from a large cross-sectional community based population epidemiological study...
2016: PloS One
https://www.readbyqxmd.com/read/27898996/calcium-pyrophosphate-deposition-disease-and-associated-medical-co-morbidities-a-national-cross-sectional-study-of-us-veterans
#2
Crystal Kleiber Balderrama, Ann K Rosenthal, Daniel Lans, Jasvinder A Singh, Christie M Bartels
OBJECTIVE: Calcium pyrophosphate crystal deposition disease (CPDD) is a common cause of acute and chronic arthritis, yet there are few large epidemiologic studies of CPDD. We sought to characterize CPDD in the national Veterans Affairs (VA) population. METHODS: Patients with International Classification of Diseases, ninth revision (ICD-9) codes for CPDD seen at any VA medical center from 2010 through 2014 were matched by age and gender with control patients without CPDD, using data from the Department of Veterans Affairs Corporate Data Warehouse...
November 29, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27896372/opioid-receptor-agonists-may-favorably-affect-bone-mechanical-properties-in-rats-with-estrogen-deficiency-induced-osteoporosis
#3
Aleksandra Janas, Joanna Folwarczna
The results of epidemiological, clinical, and in vivo and in vitro experimental studies on the effect of opioid analgesics on bone are inconsistent. The aim of the present study was to investigate the effect of morphine (an agonist of opioid receptors), buprenorphine (a partial μ opioid receptor agonist and κ opioid receptor antagonist), and naloxone (an antagonist of opioid receptors) on the skeletal system of female rats in vivo. The experiments were carried out on 3-month-old Wistar rats, divided into two groups: nonovariectomized (intact; NOVX) rats and ovariectomized (OVX) rats...
November 28, 2016: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/27889054/tocotrienols-health-and-ageing-a-systematic-review
#4
REVIEW
Ekavi N Georgousopoulou, Demosthenes B Panagiotakos, Duane D Mellor, Nenad Naumovski
OBJECTIVES: A systematic review of studies was undertaken to evaluate the potential effect of intake of tocotrienols or circulating levels of tocotrienols on parameters associated with successful ageing, specifically in relation to cognitive function, osteoporosis and DNA damage. METHODS: Following PRISMA guidelines a systematic review of epidemiological observational studies and clinical trials was undertaken. Inclusion criteria included all English language publications in the databases PubMed and Scopus, through to the end of July 2016...
January 2017: Maturitas
https://www.readbyqxmd.com/read/27875824/multimorbidity-and-burden-of-disease
#5
Todd T Brown, Giovanni Guaraldi
With effective antiretroviral therapy, HIV has become a chronic disease, and life expectancy among HIV-infected persons is approaching that of HIV-uninfected persons. Despite this success, epidemiologic evidence suggests that the burden of multiple aging-related diseases, including cardiovascular disease, liver disease, metabolic abnormalities, chronic kidney disease, cognitive dysfunction, and osteoporosis, is higher in HIV-infected persons compared to their HIV-uninfected peers. These comorbid diseases tend to cluster in a single person, leading to multimorbidity and polypharmacy...
2017: Interdisciplinary Topics in Gerontology and Geriatrics
https://www.readbyqxmd.com/read/27868152/effect-of-buffalo-casein-derived-novel-bioactive-peptides-on-osteoblast-differentiation
#6
Srinu Reddi, Venkatesa Perumal Shanmugam, Kemgang Sonfack Tanedjeu, Suman Kapila, Rajeev Kapila
PURPOSE: Epidemiological and intervention studies show that milk consumption in childhood and during adolescence is related to higher bone mineral density. Milk and milk products prevent the bone loss in pre- and postmenopausal women. Apart from calcium, there are other biologically active compounds in milk such as bioactive peptides which may play a role in promoting bone health. Casein is the major protein in milk which has also been reported to have numerous biological active peptides within it...
November 21, 2016: European Journal of Nutrition
https://www.readbyqxmd.com/read/27846926/low-dairy-calcium-intake-is-associated-with-overweight-and-elevated-blood-pressure-in-polish-adults-notably-in-premenopausal-women
#7
Elżbieta Skowrońska-Jóźwiak, Maciej Jaworski, Roman Lorenc, Małgorzata Karbownik-Lewińska, Andrzej Lewiński
OBJECTIVE: Dietary Ca is now being recognized to play an important role not only in skeletal integrity, but also in the regulation of energy and metabolism. The aim of the present study was to estimate the relationship of dairy Ca intake with BMI and blood pressure (BP) in a sample derived from the Polish population. DESIGN: Ca intake was calculated from an interviewer-administered semi-quantitative FFQ. BMI was calculated from measured weight and height, and BP was measured by a physician...
November 16, 2016: Public Health Nutrition
https://www.readbyqxmd.com/read/27846053/inaccurate-self-report-of-height-and-its-impact-on-misclassification-of-body-mass-index-in-postmenopausal-women
#8
Xiaodan Mai, Jill N Sperrazza, Britt A Marshall, Kathleen M Hovey, Jean Wactawski-Wende
OBJECTIVE: Self-reported height is commonly used in population obesity research. Evidence has also shown a positive association between depression and obesity. We examined the extent of height misreporting and its impact on body mass index (BMI) calculations and classification, and explored whether depression is associated with height misreporting. METHODS: The Buffalo Osteoporosis and Periodontal Disease Follow-up Study enrolled 1,015 postmenopausal women between 2002 and 2006...
November 14, 2016: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27833587/a-candidate-gene-association-study-of-bone-mineral-density-in-an-iranian-population
#9
Seyed Alireza Dastgheib, Alison Gartland, Seyed Mohammad Bagher Tabei, Gholamhossein Ranjbar Omrani, Marion Dawn Teare
The genetic epidemiology of variation in bone mineral density (BMD) and osteoporosis is not well studied in Iranian populations and needs more research. We report a candidate gene association study of BMD variation in a healthy cross-sectional study of 501 males and females sampled from the Iranian Multi-Centre Osteoporosis Study, Shiraz, Iran. We selected to study the association with 21 single nucleotide polymorphisms (SNPs) located in the 7 candidate genes LRP5, RANK, RANKL, OPG, P2RX7, VDR, and ESR1. BMD was measured at the three sites L2-L4, neck of femur, and total hip...
2016: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/27796445/biologic-therapies-and-bone-loss-in-rheumatoid-arthritis
#10
REVIEW
C A F Zerbini, P Clark, L Mendez-Sanchez, R M R Pereira, O D Messina, C R Uña, J D Adachi, W F Lems, C Cooper, N E Lane
INTRODUCTION: Rheumatoid arthritis (RA) is a common systemic autoimmune disease of unknown cause, characterized by a chronic, symmetric, and progressive inflammatory polyarthritis. One of the most deleterious effects induced by the chronic inflammation of RA is bone loss. During the last 15 years, the better knowledge of the cytokine network involved in RA allowed the development of potent inhibitors of the inflammatory process classified as biological DMARDs. These new drugs are very effective in the inhibition of inflammation, but there are only few studies regarding their role in bone protection...
October 31, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27766368/anti-osteoporotic-treatments-in-france-initiation-persistence-and-switches-over-6%C3%A2-years-of-follow-up
#11
M Belhassen, C B Confavreux, B Cortet, L Lamezec, M Ginoux, E Van Ganse
: Limited information is available on anti-osteoporotic treatment initiation patterns in France. In 2006-2013, the most frequently prescribed first-line treatment class for osteoporosis was represented by bisphosphonates (alendronic acid and risedronic acid), followed by strontium ranelate. Persistence with anti-osteoporotic treatment was low, with high proportions of treatment discontinuations and switches. INTRODUCTION: This epidemiological, longitudinal study described first-line treatment initiation, persistence, switches to second-line treatment, and medical care consumption in osteoporotic patients in France during the 2007-2013 period...
October 20, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27750276/multidisciplinary-portuguese-recommendations-on-dxa-request-and-indication-to-treat-in-the-prevention-of-fragility-fractures
#12
Andréa Marques, Ana M Rodrigues, José Carlos Romeu, Afonso Ruano, Ana Paula Barbosa, Eugénia Simões, Fernanda Águas, Helena Canhão, José Delgado Alves, Raquel Lucas, Jaime Cunha Branco, Jorge Laíns, Mário Mascarenhas, Susete Simões, Viviana Tavares, Oscar Lourenço, José António Pereira da Silva
OBJECTIVE: To establish Portuguese recommendations regarding the indication to perform DXA and to initiate medication aimed at the prevention of fragility fractures. METHODS: A multidisciplinary panel, representing the full spectrum of medical specialties and patient associations devoted to osteoporosis, as well as national experts in this field and in health economics, was gathered to developed recommendations based on available evidence and expert consensus. Recently obtained data on the Portuguese epidemiologic, economic and quality-of-life aspects of fragility fractures were used to support decisions...
October 18, 2016: Acta Reumatológica Portuguesa
https://www.readbyqxmd.com/read/27726930/osteoporosis-is-milk-a-kindness-or-a-curse
#13
Patrice Fardellone, Alice Séjourné, Hubert Blain, Bernard Cortet, Thierry Thomas
Cow's milk is often severely criticized as a cause of multiple health problems, including an increased risk of fractures. A close look at the scientific literature shows a striking contradiction. On the one hand, experimental studies of surrogate markers (e.g., bone turnover markers and bone mineral density [BMD]) usually indicate benefits from drinking cow's milk. On the other, the findings from epidemiological studies are conflicting and disconcerting. In all age groups, including children and postmenopausal women, consuming cow's milk, powdered milk supplements, or whey protein is associated with a slower bone turnover and unchanged or higher BMD values...
October 7, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27716144/prevalence-of-osteoporosis-in-china-a-meta-analysis-and-systematic-review
#14
Peng Chen, Zhanzhan Li, Yihe Hu
BACKGROUND: We conducted a systematic review and meta-analysis to obtain a reliable estimation of the prevalence of osteoporosis in China and to characterize its epidemiology. METHODS: We identified relevant studies via a search of literature published from 2003 to October 2015 in the PubMed, Web of Science, China National Knowledge Infrastructure, Wanfang and Weipu databases. Both Chinese and WHO criteria were considered acceptable for the diagnosis of osteoporosis...
October 3, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27703340/a-concise-review-of-testosterone-and-bone-health
#15
Nur-Vaizura Mohamad, Ima-Nirwana Soelaiman, Kok-Yong Chin
Osteoporosis is a condition causing significant morbidity and mortality in the elderly population worldwide. Age-related testosterone deficiency is the most important factor of bone loss in elderly men. Androgen can influence bone health by binding to androgen receptors directly or to estrogen receptors (ERs) indirectly via aromatization to estrogen. This review summarized the direct and indirect effects of androgens on bone derived from in vitro, in vivo, and human studies. Cellular studies showed that androgen stimulated the proliferation of preosteoblasts and differentiation of osteoblasts...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27693001/accelerated-accumulation-of-multimorbidity-after-bilateral-oophorectomy-a-population-based-cohort-study
#16
Walter A Rocca, Liliana Gazzuola-Rocca, Carin Y Smith, Brandon R Grossardt, Stephanie S Faubion, Lynne T Shuster, James L Kirkland, Elizabeth A Stewart, Virginia M Miller
OBJECTIVE: To study the association between bilateral oophorectomy and the rate of accumulation of multimorbidity. PATIENTS AND METHODS: In this historical cohort study, the Rochester Epidemiology Project records-linkage system was used to identify all premenopausal women who underwent bilateral oophorectomy before age 50 years between January 1, 1988, and December 31, 2007, in Olmsted County, Minnesota. Each woman was randomly matched to a referent woman born in the same year (±1 year) who had not undergone bilateral oophorectomy...
November 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27666684/-epidemiology-of-respiratory-diseases-and-osteoporosis
#17
Saeko Fujiwara
A large scale of epidemiological studies demonstrated that osteoporosis risk was about 1.5 times higher and fracture risk was 1.2-1.8 times higher among COPD patients. In COPD, risk factors for fracture have been reported to be severity of the COPD and use of bronchodilator in addition to ordinal risk factors for the fracture such as age, previous fracture, smoking, usage of glucocorticoid and others. There were inconsistent results of the relationship between sleep apnea and low bone mass. The relationship was found between sleep apnea and fall and non-spin fracture risk...
2016: Clinical Calcium
https://www.readbyqxmd.com/read/27649491/prediction-of-bone-mineral-density-and-fragility-fracture-by-genetic-profiling
#18
Thao P Ho-Le, Jacqueline R Center, John A Eisman, Hung T Nguyen, Tuan V Nguyen
AIM: Although the susceptibility to fracture is partly determined by genetic factors, the contribution of newly discovered genetic variants to fracture prediction is still unclear. This study sought to define the predictive value of a genetic profiling for fracture prediction. METHODS: Sixty-two bone mineral density (BMD)-associated single-nucleotide polymorphism (SNP) were genotyped in 557 men and 902 women who had participated in the Dubbo Osteoporosis Epidemiology Study...
September 20, 2016: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/27622174/osteoporosis-associated-with-chronic-obstructive-pulmonary-disease
#19
REVIEW
Ryo Okazaki, Reiko Watanabe, Daisuke Inoue
Recent epidemiological studies have revealed that osteoporosis is closely associated with common chronic diseases including diabetes, hypertension, chronic kidney disorders, and chronic obstructive pulmonary disease (COPD). COPD is a chronic inflammatory airway disease but now well known to be associated with various systemic comorbidities including osteoporosis. Osteoporosis and osteoporotic fractures are extremely common in COPD patients, which have significant impacts on their quality of life (QOL), activities of daily life (ADL), respiratory function, and possibly their prognosis...
August 2016: Journal of Bone Metabolism
https://www.readbyqxmd.com/read/27618368/the-relationship-of-knowledge-of-osteoporosis-and-bone-health-in-postmenopausal-women-in-silesia-osteo-active-study
#20
E Tabor, R Kuźniewicz, P Zagórski, K Martela, W Pluskiewicz
The Silesia Osteo Active Study was designed to assess osteoporosis-related knowledge and its relationships with skeletal status in an epidemiological population-based program. Participants were chosen randomly from postmenopausal women over 55 yr. The study group consisted of 388 patients (mean age 65 ± 7). All participants fulfilled medical and socioeconomic questionnaires and test concerning osteoporosis-related knowledge. They underwent proximal femur and lumbar spine densitometry. The mean level of osteoporosis knowledge was 7...
September 8, 2016: Journal of Clinical Densitometry
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