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osteoporosis epidemiology

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https://www.readbyqxmd.com/read/28535619/prevalence-and-incidence-of-osteoporotic-fractures-in-patients-on-long-term-glucocorticoid-treatment-for-rheumatic-diseases-the-glucocorticoid-induced-osteoporosis-tool-giotto-study
#1
M Rossini, O Viapiana, M Vitiello, N Malavolta, G La Montagna, S Maddali Bongi, O Di Munno, R Nuti, C U Manzini, C Ferri, L Bogliolo, A Mathieu, F Cantatore, A Del Puente, M Muratore, W Grassi, B Frediani, G Saviola, P Delvino, L Mirone, G Ferraccioli, G Tripi, I Piazza, D Gatti
Osteoporosis and fractures are common and invalidating consequences of chronic glucorticoid (GC) treatment. Reliable information regarding the epidemiology of GC induced osteoporosis (GIOP) comes exclusively from the placebo group of randomized clinical trials while observational studies are generally lacking data on the real prevalence of vertebral fractures, GC dosage and primary diagnosis. The objective of this study was to evaluate the prevalence and incidence of osteoporotic fractures and to identify their major determinants (primary disease, GC dosage, bone mineral density, risk factors, specific treatment for GIOP) in a large cohort of consecutive patients aged >21 years, on chronic treatment with GC (≥5 mg prednisone - PN - equivalent) and attending rheumatology centers located all over Italy...
May 22, 2017: Reumatismo
https://www.readbyqxmd.com/read/28463945/epidemiology-of-fractures-in-children-younger-than-12-months
#2
Diana Rodà, Victoria Trenchs, Ana Isabel Curcoy, Anibal Dolores Martínez, Jordi Pou, Carles Luaces
OBJECTIVES: The aim of this study is to determine the prevalence and characteristics of fractures in young infants attended at the pediatric emergency department (PED). METHODS: This is a retrospective study for 2 years (2011-2012) of children younger than 12 months attended with a fracture at the PED. Age, sex, site and type of fracture, mechanism of injury, time interval before seeking medical attention, and management were analyzed. RESULTS: One hundred one patients were included...
May 1, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28457494/vitamin-d-status-and-the-host-resistance-to-infections-what-it-is-currently-not-understood
#3
Pierre Olivier Lang, Richard Aspinall
PURPOSE: Vitamin D is increasingly thought to play a role in regulating immunity. This comprehensive review updates the current understanding regarding ways in which we believe that vitamin D regulates responsiveness of the immune system and how serum status modulates the host defense against pathogens. METHODS: The literature was searched by using PubMed and Scopus with the following key words: vitamin D, immunity, innate and adaptive immunity, infectious disease, and vaccine response...
April 27, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28451733/identification-and-management-of-patients-at-increased-risk-of-osteoporotic-fracture-outcomes-of-an-esceo-expert-consensus-meeting
#4
REVIEW
J A Kanis, C Cooper, R Rizzoli, B Abrahamsen, N M Al-Daghri, M L Brandi, J Cannata-Andia, B Cortet, H P Dimai, S Ferrari, P Hadji, N C Harvey, M Kraenzlin, A Kurth, E McCloskey, S Minisola, T Thomas, J-Y Reginster
Osteoporosis represents a significant and increasing healthcare burden in Europe, but most patients at increased risk of fracture do not receive medication, resulting in a large treatment gap. Identification of patients who are at particularly high risk will help clinicians target appropriate treatment more precisely and cost-effectively, and should be the focus of future research. INTRODUCTION: The purpose of the study was to review data on the identification and treatment of patients with osteoporosis at increased risk of fracture...
April 27, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28441168/a-review-of-caffeine-use-as-a-risk-or-protective-factor-for-women-s-health-and-pregnancy
#5
Amy Peacock, Richard P Mattick, Raimondo Bruno
PURPOSE OF REVIEW: To provide a narrative synthesis of recently published studies on caffeine use as a risk or protective factor for health outcomes, with a focus on women's health and pregnancy. RECENT FINDINGS: Based on predominantly observational studies, moderate caffeine intake has been shown to be a protective factor for liver cancer, certain bowel conditions, colorectal cancer, skin cancer, and regular menstrual cycle function. However, heavy consumption is a risk factor for osteoporosis, urinary incontinence, and poorer birth and child developmental outcomes...
April 22, 2017: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28439058/-calcium-and-bone-metabolism-across-women-s-life-stages-stress-fracture-in-female-athletes
#6
Kazuyoshi Yagishita
Stress fractures are common overuse injuries in athletes, especially in long-distance runner, jumping sports and gymnastics in female athletes. The pathology of stress fracture mainly includes repeated biomechanical loading, which leads to bone micro-damage and failure of bone structure. Female athlete triad(FAT), which includes low energy availability with or without an eating disorder, functional hypothalamic amenorrhea, and osteoporosis, is a serious healthcare concern in female athletes. For prevention and treatment of stress fracture, management of biomechanical factors modifying the load applied to a bone is important, and especially in female athletes, management for FAT is one of the important factors...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28439049/-calcium-and-bone-metabolism-across-women-s-life-stages-epidemiology-of-bone-and-joint-disease-in-japanese-women
#7
Shigeyuki Muraki
Bone and joint diseases are severe problems in the elderly;therefore, the development of their treatment or prophylaxis is quite important. Our study shows that the prevalence of osteoporosis and osteoarthritis is very high, and its impact on quality of life is strong. The treatment rate of osteoporosis is less than 10%, and awareness programs for prevention of osteoporosis and osteoarthritis disorders such as locomotive syndrome are needed.
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28392715/positive-predictive-values-of-international-classification-of-diseases-10th-revision-codes-for-dermatologic-events-and-hypersensitivity-leading-to-hospitalization-or-emergency-room-visit-among-women-with-postmenopausal-osteoporosis-in-the-danish-and-swedish
#8
Kasper Adelborg, Lotte Brix Christensen, Troels Munch, Johnny Kahlert, Ylva Trolle Lagerros, Grethe S Tell, Ellen M Apalset, Fei Xue, Vera Ehrenstein
BACKGROUND: Clinical epidemiology research studies, including pharmacoepidemiology and pharmacovigilance studies, use routinely collected health data, such as diagnoses recorded in national health and administrative registries, to assess clinical effectiveness and safety of treatments. We estimated positive predictive values (PPVs) of International Classification of Diseases, 10th revision (ICD-10) codes for primary diagnoses of dermatologic events and hypersensitivity recorded at hospitalization or emergency room visit in the national patient registries of Denmark and Sweden among women with postmenopausal osteoporosis (PMO)...
2017: Clinical Epidemiology
https://www.readbyqxmd.com/read/28386693/osteoporosis-obesity-and-sarcopenia-on-abdominal-ct-a-review-of-epidemiology-diagnostic-criteria-and-management-strategies-for-the-reporting-radiologist
#9
REVIEW
Timothy É Murray, David Williams, Michael J Lee
Abdominal computed tomography (CT) is a widely performed examination, with many indications. Assessment of bone, fat, and muscle on abdominal CT can be performed in a quantitative manner. Published studies have developed diagnostic cutoffs for osteoporosis, obesity, and sarcopenia, which are summarized with pictorial examples. The epidemiological and prognostic significance of these disease states are outlined. Further diagnostic steps and treatment strategies are outlined to inform both the managing clinician and reporting radiologist...
April 6, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28382112/the-role-of-vitamin-d-in-maintaining-bone-health-in-older-people
#10
REVIEW
Thomas R Hill, Terry J Aspray
This review summarises aspects of vitamin D metabolism, the consequences of vitamin D deficiency, and the impact of vitamin D supplementation on musculoskeletal health in older age. With age, changes in vitamin D exposure, cutaneous vitamin D synthesis and behavioural factors (including physical activity, diet and sun exposure) are compounded by changes in calcium and vitamin D pathophysiology with altered calcium absorption, decreased 25-OH vitamin D [25(OH)D] hydroxylation, lower renal fractional calcium reabsorption and a rise in parathyroid hormone...
April 2017: Therapeutic Advances in Musculoskeletal Disease
https://www.readbyqxmd.com/read/28371498/chinese-guideline-for-the-diagnosis-and-treatment-of-osteonecrosis-of-the-femoral-head-in-adults
#11
(no author information available yet)
The treatment of adult osteonecrosis of the femoral head (ONFH), with 8.12 million patients in China, remains a challenge to surgeons. To standardize and improve the efficacy of the treatment of ONFH, Chinese specialists updated the experts' suggestions in March 2015, and an experts' consensus was given to provide a current basis for the diagnosis, treatment and evaluation of ONFH. The current guideline provides recommendations for ONFH with respect to epidemiology, etiology, diagnostic criteria, differential diagnosis, staging, treatment, as well as rehabilitation...
February 2017: Orthopaedic Surgery
https://www.readbyqxmd.com/read/28369266/klinefelter-syndrome-comorbidities-linked-to-increased-x-chromosome-gene-dosage-and-altered-protein-interactome-activity
#12
Kirstine Belling, Francesco Russo, Anders B Jensen, Marlene D Dalgaard, David Westergaard, Ewa Rajpert-De Meyts, Niels E Skakkebæk, Anders Juul, Søren Brunak
Klinefelter syndrome (KS) (47,XXY) is the most common male sex chromosome aneuploidy. Diagnosis and clinical supervision remain a challenge due to varying phenotypic presentation and insufficient characterization of the syndrome. Here we combine health data-driven epidemiology and molecular level systems biology to improve the understanding of KS and the molecular interplay influencing its comorbidities. In total, 78 overrepresented KS comorbidities were identified using in- and out-patient registry data from the entire Danish population covering 6...
April 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28348479/non-alcoholic-fatty-liver-disease-connections-with-fat-free-tissues-a-focus-on-bone-and-skeletal-muscle
#13
REVIEW
Eleonora Poggiogalle, Lorenzo Maria Donini, Andrea Lenzi, Claudio Chiesa, Lucia Pacifico
The estimates of global incidence and prevalence of non-alcoholic fatty liver disease (NAFLD) are worrisome, due to the parallel burden of obesity and its metabolic complications. Indeed, excess adiposity and insulin resistance represent two of the major risk factors for NAFLD; interestingly, in the last years a growing body of evidence tended to support a novel mechanistic perspective, in which the liver is at the center of a complex interplay involving organs and systems, other than adipose tissue and glucose homeostasis...
March 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28342139/exploring-the-link-between-posttraumatic-stress-disorder-and-inflammation-related-medical-conditions-an-epidemiological-examination
#14
Jack Tsai, Jianxun Shen
There have been few epidemiological studies exploring the link between PTSD and inflammation using population-based samples. This study examined the relation between posttraumatic stress disorder (PTSD) and inflammation-related medical conditions using data from the 2013-2014 New York City Health and Nutrition Examination Survey. Using a representative sample of 1,527 residents in New York City, the association between PTSD and 17 inflammation-related medical conditions were examined. Bivariate and multivariable analyses were conducted, adjusting for demographic characteristics and lifetime depression...
March 25, 2017: Psychiatric Quarterly
https://www.readbyqxmd.com/read/28337901/cardiopathy-and-osteoporosis-the-epidemiology-in-a-region-of-italy
#15
A Notarnicola, G Maccagnano, L Moretti, S Tafuri, B Moretti
Cardiopathies and osteoporosis are inter-related due to pathogenetic, hormonal, genetic features as well as an increased risk of fragility. An important feature is attributed to the process of atherosclerosis, which is responsible for an osteopenia effect and degeneration of vascular walls. To date the study populations have been limited. To verify the incidence of cardio-vascular disease in a larger osteoporotic population, we designed a retrospective clinical study analyzing the “Hospital Discharge Data” (HDD) in Apulia between 2006 and 2010...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28324124/osteoporosis-in-frail-patients-a-consensus-paper-of-the-belgian-bone-club
#16
REVIEW
E Gielen, P Bergmann, O Bruyère, E Cavalier, P Delanaye, S Goemaere, J-M Kaufman, M Locquet, J-Y Reginster, S Rozenberg, A-M Vandenbroucke, J-J Body
In this consensus paper, the Belgian Bone Club aims to provide a state of the art on the epidemiology, diagnosis, and management of osteoporosis in frail individuals, including patients with anorexia nervosa, patients on dialysis, cancer patients, persons with sarcopenia, and the oldest old. All these conditions may indeed induce bone loss that is superimposed on physiological bone loss and often remains under-recognized and under-treated. This is of particular concern because of the major burden of osteoporotic fractures in terms of morbidity, mortality, and economic cost...
March 21, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28299033/the-association-of-age-and-gender-with-risk-factors-of-noncommunicable-diseases-among-employees-in-west-of-iran
#17
Nahid Khademi, Mehran Babanejad, Atefeh Asadmobini, Hossein Karim
BACKGROUND: The relationships that age and gender share with risk factors (RFs) of noncommunicable diseases (NCDs) were assessed among a large-scale employ in Western Iran. METHODS: In this epidemiologic cross-sectional study, 7129 employees from Kermanshah Province were assessed using a census method in 2012. Data on RFs of NCD were collected using a standard questionnaire. Demographic information, diet, physical activity, tobacco use, and history of hypertension, history of diabetes, cardiovascular diseases, osteoporosis, and cancer were studied...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28298072/the-anti-osteoporotic-and-anti-atherogenic-effects-of-alendronate-and-simvastatin-in-ovariectomized-rats-fed-high-fat-diet-a-comparative-study-of-combination-therapy-versus-monotherapy
#18
Maha Tarek Mohamed, Sally A Abuelezz, Suzi Sobhy Atalla, Lobna Fouad Abd El Aziz, Sonia Salib Gorge
AIM: Epidemiological studies suggest a possible link between osteoporosis and cardiovascular diseases. Mevalonate pathway was pointed to as a part of this link. This study was done to investigate the effects of Alendronate (Al) and Simvastatin (Sim), both act on the mevalonate pathway, on osteoporosis, dyslipidemia and atherosclerotic changes in ovariectomized (OVX) rats fed high fat diet (HFD). MAIN METHODS: 60 female albino rats were equally divided into 5 groups: control sham, OVX-HFD untreated, OVX -HFD treated with Al (3mg/kg/d) or/and Sim (6mg/kg/d)...
May 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28283938/seasonal-variation-in-internet-searches-for-vitamin-d
#19
Rebecca J Moon, Elizabeth M Curtis, Justin H Davies, Cyrus Cooper, Nicholas C Harvey
Internet search rates for "vitamin D" were explored using Google Trends. Search rates increased from 2004 until 2010 and thereafter displayed a seasonal pattern peaking in late winter. This knowledge could help guide the timing of public health interventions aimed at managing vitamin D deficiency. PURPOSE: The Internet is an important source of health information. Analysis of Internet search activity rates can provide information on disease epidemiology, health related behaviors and public interest...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28258372/fracture-burden-what-two-and-a-half-decades-of-dubbo-osteoporosis-epidemiology-study-data-reveal-about-clinical-outcomes-of-osteoporosis
#20
REVIEW
Jacqueline R Center
PURPOSE OF THE REVIEW: This review aims to highlight important clinical findings from the over 25 year-long Dubbo Osteoporosis Epidemiology Study particularly focusing on outcomes post fracture. RECENT FINDINGS: Every low trauma fracture in the elderly is associated with an increased risk of a subsequent fracture, with a higher risk in men than women. All major or proximal fractures and even minor fractures in the very elderly or minor fractures that are then followed by re-fracture are associated with premature mortality, greatest in the first 5 years post fracture...
March 3, 2017: Current Osteoporosis Reports
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