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https://www.readbyqxmd.com/read/29141157/the-devastating-effect-of-exposure-to-high-irradiation-dose-on-liver-and-the-performance-of-synthesized-nano-hap-in-relieve-the-associated-symptoms-in-rats
#1
Eman Ismail Gheriany, Sameh A Awwad
Ionizing radiation is one of the environmental factors that may contribute to liver dysfunction by a mechanism involving oxidative stress. The present investigation was undertaken to study the possible therapeutic effect of nano-HAp on whole body gamma irradiation induced hepatotoxicity in rats. The study consisted of three groups of 10 rats each. Group 1 (control), whereas group 2 received a single dose of γ-radiation (10Gy). The animals in groups 3 was treated with nano-HAp (100 mg/kg b.w.) once / week for three weeks starting in the next day of γ radiation...
November 15, 2017: Biochemistry and Cell Biology, Biochimie et Biologie Cellulaire
https://www.readbyqxmd.com/read/29141132/intra-species-volatile-interactions-affects-growth-rates-and-exometabolomes-in-aspergillus-oryzae-kccm-60345
#2
Digar Singh, Choong Hwan Lee
The volatile organic compounds (VOCs) are increasingly been recognized as the chemical mediators of mold interactions shaping their community dynamic, growth, and metabolism. Herein, we selectively examined the time-correlated (0 D - 11 D) effects of intra-species VOCs mediated interactions (VMI) on Aspergillus oryzae KCCM 60345 (S1), following co-cultivation with partner strain A. oryzae KACC 44967 (S2), in specially designed twin plate assembly. The comparative evaluation of S1VMI (S1 subjected to VMI with S2) and its control (S1con) showed a notable disparity in their radial growth (S1VMI<S1con) at 5 D, protease activity (S1VMI>S1con) at 3-5 D, amylase activity (S1VMI<S1con) at 3-5 D, and antioxidant levels (S1VMI>S1con) at 3 D...
November 15, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29141035/influence-of-boron-supplementation-on-performance-immunity-and-antioxidant-status-of-lambs-fed-diets-with-or-without-adequate-level-of-calcium
#3
T Vijay Bhasker, N K S Gowda, D T Pal, S Karthik Bhat, P Krishnamoorthy, S Mondal, A K Pattanaik, A K Verma
Little is known about biological significance of effects of dietary Boron (B) and Calcium (Ca) interaction on health and production of farm animals. This is a preliminary investigation to evaluate the effects of B supplementation in lambs fed diets with (normal) or without adequate (low) levels of Ca. Twenty-four crossbred ram lambs were randomly distributed into four groups with six animals each in a 2x2 factorial design namely, normal-Ca diet (NCa) and low-Ca diet (LCa) fed without or with 40 ppm B (NCaB-40 and LCaB-40)...
2017: PloS One
https://www.readbyqxmd.com/read/29140578/alleviation-of-cadmium-induced-oxidative-stress-by-trehalose-via-inhibiting-the-nrf2-keap1-signaling-pathway-in-primary-rat-proximal-tubular-cells
#4
Xin-Yu Wang, Zhen-Yong Wang, Yi-Song Zhu, Si-Ming Zhu, Rui-Feng Fan, Lin Wang
Nuclear factor erythroid 2-related factor 2 (Nrf2) is a transcription factor that regulates a cluster of oxidative stress-inducible genes in cells. Here, we aimed to investigate whether trehalose (Tre) protects primary rat proximal tubular (rPT) cells against cadmium (Cd)-induced oxidative stress via Nrf2 antioxidant pathway. Data showed that Tre treatment inhibited Nrf2 nuclear translocation and restored the decline in Kelch-like ECH-associated protein 1 (Keap1) protein level in Cd-exposed rPT cells. Moreover, Cd-activated Nrf2 target genes, including phase II detoxifying enzymes, that is, NAD(P)H quinone oxidoreductase 1 and heme oxygenase-1, direct antioxidant proteins, that is, glutathione peroxidase, superoxide dismutase, catalase, and glutathione biosynthesis-related proteins, that is, glutamatecysteine ligase catalytic subunit, glutamate cysteine ligase modifier subunit, and glutathione reductase, were all downregulated by co-treatment with Tre...
November 15, 2017: Journal of Biochemical and Molecular Toxicology
https://www.readbyqxmd.com/read/29140297/a-proteomic-approach-to-investigate-the-drought-response-in-the-orphan-crop-eragrostis-tef
#5
Rizqah Kamies, Jill M Farrant, Zerihun Tadele, Gina Cannarozzi, Mohammed Suhail Rafudeen
The orphan crop, Eragrostis tef, was subjected to controlled drought conditions to observe the physiological parameters and proteins changing in response to dehydration stress. Physiological measurements involving electrolyte leakage, chlorophyll fluorescence and ultra-structural analysis showed tef plants tolerated water loss to 50% relative water content (RWC) before adverse effects in leaf tissues were observed. Proteomic analysis using isobaric tag for relative and absolute quantification (iTRAQ) mass spectrometry and appropriate database searching enabled the detection of 5727 proteins, of which 211 proteins, including a number of spliced variants, were found to be differentially regulated with the imposed stress conditions...
November 15, 2017: Proteomes
https://www.readbyqxmd.com/read/29140290/ameliorative-effects-of-grape-seed-proanthocyanidin-extract-on-growth-performance-immune-function-antioxidant-capacity-biochemical-constituents-liver-histopathology-and-aflatoxin-residues-in-broilers-exposed-to-aflatoxin-b%C3%A2
#6
Shahid Ali Rajput, Lvhui Sun, Niya Zhang, Mahmoud Mohamed Khalil, Xin Gao, Zhao Ling, Luoyi Zhu, Farhan Anwar Khan, Jiacai Zhang, Desheng Qi
Aflatoxicosis is a grave threat to the poultry industry. Dietary supplementation with antioxidants showed a great potential in enhancing the immune system; hence, protecting animals against aflatoxin B₁-induced toxicity. Grape seed proanthocyanidin extract (GSPE) one of the most well-known and powerful antioxidants. Therefore, the purpose of this research was to investigate the effectiveness of GSPE in the detoxification of AFB₁ in broilers. A total of 300 one-day-old Cobb chicks were randomly allocated into five treatments of six replicates (10 birds per replicate), fed ad libitum for four weeks with the following dietary treatments: 1...
November 15, 2017: Toxins
https://www.readbyqxmd.com/read/29140278/development-of-gallic-acid-modified-hydrogels-using-interpenetrating-chitosan-network-and-evaluation-of-their-antioxidant-activity
#7
Byungman Kang, Temmy Pegarro Vales, Byoung-Ki Cho, Jong-Ki Kim, Ho-Joong Kim
In this work, antioxidant hydrogels were prepared by the construction of an interpenetrating chitosan network and functionalization with gallic acid. The poly(2-hydroxyethyl methacrylate) p(HEMA)-based hydrogels were first synthesized and subsequently surface-modified with an interpenetrating polymer network (IPN) structure prepared with methacrylamide chitosan via free radical polymerization. The resulting chitosan-IPN hydrogels were surface-functionalized with gallic acid through an amide coupling reaction, which afforded the antioxidant hydrogels...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29140273/larix-decidua-bark-as-a-source-of-phytoconstituents-an-lc-ms-study
#8
Valeria Baldan, Stefania Sut, Marta Faggian, Elena Dalla Gassa, Sara Ferrari, Gabriele De Nadai, Stefano Francescato, Gianni Baratto, Stefano Dall'Acqua
Larix decidua bark is a waste of the timber industry and is widely diffused in Northern Italy. This material can be considered a good source of antioxidants and phytoconstituents with possible use in cosmetic or nutraceutical products. In this study, simple extraction of larch bark was performed using mixtures of ethanol/water. Furthermore, the phytochemical composition of larch bark extract was studied using LC-MS(n) methods and the main constituents were identified as flavonoids, spiro-polyphenols, and procyanidins...
November 15, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29139577/copper-uptake-patterns-of-bioaccumulation-and-effects-in-glochidia-larvae-of-the-freshwater-mussel-lampsilis-cardium
#9
Marianna Basso Jorge, Adalto Bianchini, Chris M Wood, Patricia L Gillis
The early life stages of freshwater mussels are particularly sensitive to Cu contamination. We measured the acute toxicity, bioaccumulation and sublethal effects of Cu in glochidia. Additionally, we used radiolabeled Cu ((64) Cu) to examine the time-dependent kinetics of uptake over 24 h. (64) Cu uptake by live and dead glochidia exposed to 0.11 μmol/L exhibited similar hyperbolic patterns over the first 40 min, indicating an adsorptive phase independent of larval metabolism. Thereafter, uptake was linear with time, with a 10-fold lower bioaccumulation rate in live than in dead animals, representing a close to steady state of Cu regulation...
November 15, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29139323/jaboticaba-plinia-peruviana-extract-nanoemulsions-development-stability-and-in-vitro-antioxidant-activity
#10
Letícia Mazzarino, Heloísa da Silva Pitz, Ana Paula Lorenzen Voytena, Adriana Carla Dias Trevisan, Rosa Maria Ribeiro-Do-Valle, Marcelo Maraschin
OBJECTIVE: The aim of this work is to develop and characterize nanoemulsions containing jaboticaba extract (Plinia peruviana) aiming pharmaceutical and cosmetic applications. METHODS: Nanoemulsions were prepared by high-pressure homogenization method using different concentrations of components (oil, surfactant, and extract) and homogenization pressures, in order to optimize the preparation conditions. Both unloaded and extract-loaded nanoemulsions were characterized according their size, polydispersity, zeta potential, pH, morphology, and physical stability...
November 15, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29139225/oolong-tea-prevents-cardiomyocyte-loss-against-hypoxia-by-attenuating-p-jnk-mediated-hypertrophy-and-enhancing-p-igf1r-p-akt-and-p-bad-ser136-activity-and-by-fortifying-nrf2-antioxidation-system
#11
Marthandam Asokan Shibu, Chia-Hua Kuo, Bih-Cheng Chen, Da-Tong Ju, Ray-Jade Chen, Chao-Hung Lai, Pei-Jane Huang, Vijaya Padma Viswanadha, Wei-Wen Kuo, Chih-Yang Huang
Tea, the most widely consumed natural beverage has been associated with reduced mortality risk from cardiovascular disease. Oolong tea is a partially fermented tea containing high levels of catechins, their degree of oxidation varies between 20%-80% causing differences in their active metabolites. In this study we examined the effect of oolong tea extract (OTE) obtained by oxidation at low-temperature for short-time against hypoxic injury and found that oolong tea provides cyto-protective effects by suppressing the JNK mediated hypertrophic effects and by enhancing the innate antioxidant mechanisms in neonatal cardiomyocytes and in H9c2 cells...
November 15, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29139109/%C3%AE-cyclodextrin-encapsulated-polyphenols-as-effective-antioxidants
#12
Pritam Roy, Amit Kumar Dinda, Susmitnarayan Chaudhury, Swagata Dasgupta
Formation of dityrosine (DT) cross-linkages in proteins is one of the most widely used markers of oxidative stress. Ribonuclease A (RNase A) has 6 Tyr residues and shows a characteristic DT fluorescence peak upon oxidation in addition to major changes in its secondary structure. DT formation can be prevented by using polyphenols (GA, ECG, and EGCG) which are known to have strong antioxidant activity. However, it has been observed that ECG and EGCG initiate protein oligomerization due to protein-polyphenol cross-linkages...
November 15, 2017: Biopolymers
https://www.readbyqxmd.com/read/29139087/the-role-of-reactive-oxygen-species-in-adipogenic-differentiation
#13
Danielle de Villiers, Marnie Potgieter, Melvin A Ambele, Ladislaus Adam, Chrisna Durandt, Michael S Pepper
Interest in reactive oxygen species and adipocyte differentiation/adipose tissue function is steadily increasing. This is due in part to a search for alternative avenues for combating obesity, which results from the excess accumulation of adipose tissue. Obesity is a major risk factor for complex disorders such as cancer, type 2 diabetes, and cardiovascular diseases. The ability of mesenchymal stromal/stem cells (MSCs) to differentiate into adipocytes is often used as a model for studying adipogenesis in vitro...
November 15, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29139074/excessive-use-of-nitrogenous-fertilizers-an-unawareness-causing-serious-threats-to-environment-and-human-health
#14
Moddassir Ahmed, Muhammad Rauf, Zahid Mukhtar, Nasir Ahmad Saeed
Farmers occasionally need to add nitrogen fertilizer to their farms and gardens to make available just the precise nutrients for their plants' growth. The applications of inorganic nitrogen fertilizers to various crops have been continuously increasing since last many decades globally. Although nitrogen fertilizer contributes substantially to yield enhancement, but excessive use of this manure has posed serious threats to environment and human health. Rate of nitrogen fertilizers application has a close relationship with nitrate accumulation in surrounding environment, groundwater, as well as leafy and root vegetables...
November 14, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29138814/grape-seed-proanthocyanidin-extract-attenuates-varicocele%C3%A2-induced-testicular-oxidative-injury-in-rats-by-activating-the-nrf2%C3%A2-antioxidant-system
#15
Yong Wang, Fan Chen, Ming Liang, Shouzhen Chen, Yaofeng Zhu, Zhichuan Zou, Benkang Shi
The present study investigated whether grape seed proanthocyanidin extract (GSPE) can attenuate varicocele‑induced testicular oxidative injury through the nuclear factor (erythroid‑derived 2)‑like 2 (Nrf2) antioxidant pathway. A varicocele model in rats was established by partial ligation of the left renal vein. Following 4 weeks of GSPE administration, the decreased sperm count and motility and other pathological changes caused by varicocele were significantly alleviated, as indicated by the results of computer‑assisted sperm analysis and hematoxylin and eosin staining...
November 10, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29138805/extracellular-polysaccharides-purified-from-aureobasidium-pullulans-sm%C3%A2-2001-polycan-inhibit-dexamethasone%C3%A2-induced-muscle-atrophy-in-mice
#16
Jong-Min Lim, Young Joon Lee, Hyung-Rae Cho, Dong-Chan Park, Go-Woon Jung, Sae Kwang Ku, Jae-Suk Choi
The present study assessed the beneficial skeletal muscle‑preserving effects of extracellular polysaccharides from Aureobasidium pullulans SM‑2001 (Polycan) (EAP) on dexamethasone (DEXA)‑induced catabolic muscle atrophy in mice. To investigate whether EAP prevented catabolic DEXA‑induced muscle atrophy, and to examine its mechanisms of action, EAP (100, 200 and 400 mg/kg) was administered orally, once a day for 24 days. EAP treatment was initiated 2 weeks prior to DEXA treatment (1 mg/kg, once a day for 10 days) in mice...
November 10, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29138799/lychee-seed-extract-protects-against-neuronal-injury-and-improves-cognitive-function-in-rats-with-type-ii-diabetes-mellitus-with-cognitive-impairment
#17
Yong Tang, Chonglin Yu, Jianming Wu, Haixia Chen, Yuan Zeng, Xiuling Wang, Le Yang, Qibing Mei, Shousong Cao, Dalian Qin
Lychee seed is a traditional Chinese medicine and has many beneficial effects such as modulation of blood sugar and lipids, antioxidation, antivirus and antitumor. Studies have indicated that type II diabetes mellitus (T2DM) and Alzheimer's disease (AD) share common biological mechanisms including insulin resistance, impaired glucose metabolism, β‑amyloid (Aβ) formation, oxidative stress and presence of advanced glycation end products (AGEs). The present study investigated the effects of lychee seed extract (LSE) on neuroprotection, cognitive function improvement and possible underlying mechanisms in a rat model of T2DM with cognitive impairment...
November 9, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29138791/a-new-heteropolysaccharide-from-the-seed-husks-of-plantago-asiatica-l-with-its-thermal-and-antioxidant-properties
#18
Yuge Niu, Na Li, Sierkemideke Alaxi, Guoren Huang, Lei Chen, Ziqian Feng
A new heteropolysaccharide (PMH) with a molecular weight of 1.4 × 10(3) kDa was isolated from the seed husks of Plantago asiatica L. The monosaccharide composition of PMH was determined as glucose, xylose, arabinose, rhamnose, galactose and galacturonic acid with a molar ratio of 1.0 : 1.8 : 2.4 : 3.8 : 4.9 : 8.5. The backbone of PMH consisted of 1,4-β-d-GalpA with the side chains mainly composed of 1,3-α-d-Galp and 1,2-α-d-Galp which were attached to the O-3 of GlapA. The thermal analysis using the Flynn-Wall-Ozawa (FWO) method revealed that PMH had an apparent activation energy (Ea) of 173...
November 15, 2017: Food & Function
https://www.readbyqxmd.com/read/29138682/mir-128-is-implicated-in-stress-responses-by-targeting-mafg-in-skeletal-muscle-cells
#19
Rocco Caggiano, Fabio Cattaneo, Ornella Moltedo, Giovanni Esposito, Cinzia Perrino, Bruno Trimarco, Rosario Ammendola, Raffaella Faraonio
MAFG (v-Maf avian musculoaponeurotic fibrosarcoma oncogene homolog G) is a bZIP-type transcriptional regulator that belongs to the small MAF (sMAFs) protein family. By interacting with other bZIP transcription factors, sMAFs can form homo- and heterodimers governing either repressive or activating transcriptional functions. As heterodimeric partner of Nrf2, MAFG positively influences the ARE-dependent antioxidant/xenobiotic pathways, at least in condition of a correct MAFG:Nrf2 balance. MicroRNAs (miRs) participate to different regulatory networks being involved as fine-tuning regulators of gene expression...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29138680/enhancement-of-antioxidant-mechanisms-and-reduction-of-oxidative-stress-in-chickens-after-the-administration-of-drinking-water-enriched-with-polyphenolic-powder-from-olive-mill-waste-waters
#20
Aliki Papadopoulou, Konstantinos Petrotos, Dimitrios Stagos, Konstantinos Gerasopoulos, Antonios Maimaris, Haralampos Makris, Ioannis Kafantaris, Sotiria Makri, Efthalia Kerasioti, Maria Halabalaki, Vincent Brieudes, Georgia Ntasi, Stylianos Kokkas, Pavlos Tzimas, Panagiotis Goulas, Alexander M Zakharenko, Kirill S Golokhvast, Aristidis Tsatsakis, Demetrios Kouretas
The aim of the study was to examine the effects of a polyphenolic powder from olive mill wastewater (OMWW) administered through drinking water, on chickens' redox status. Thus, 75 chickens were divided into three groups. Group A was given just drinking water, while groups B and C were given drinking water containing 20 and 50 μg/ml of polyphenols, respectively, for 45 days. The antioxidant effects of the polyphenolic powder were assessed by measuring oxidative stress biomarkers in blood after 25 and 45 days of treatment...
2017: Oxidative Medicine and Cellular Longevity
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