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https://www.readbyqxmd.com/read/28944905/myricitrin-decreases-traumatic-injury-of-the-spinal-cord-and-exhibits-antioxidant-and-anti%C3%A2-inflammatory-activities-in-a-rat-model-via-inhibition-of-cox%C3%A2-2-tgf%C3%A2-%C3%AE-1-p53-and-elevation-of-bcl%C3%A2-2-bax-signaling-pathway
#1
Yang Lei
Myricitrin has multiple effects, including antagonism of platelet activating factor, regulation of blood sugar levels, oxidation resistance, protection of the liver and the relieving of ethylism. The present study evaluated how myricitrin weakens traumatic injury of the spinal cord (TISC), and exhibits antioxidant and anti‑inflammatory activities in a rat model. TISC model rats were injected intraperitoneally with 5, 10 or 30 mg/kg/day of myricitrin for 5 days. Basso‑Beattie‑Bresnahan evaluation of locomotion and water content of spinal cord were used to analyze the effects of myricitrin on TISC...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944889/beneficial-effects-of-extracts-from-lucilia%C3%A2-sericata-maggots-on-burn-wounds-in-rats
#2
Haixu Bian, Qiaoli Yang, Tao Ma, Wei Li, Jialin Duan, Guo Wei, Xiaoxiao Wu, Fei Mu, Rui Lin, Aidong Wen, Miaomiao Xi
Lucilia sericata maggots have beneficial properties; however, their protective effects on burn wounds have yet to be fully elucidated. In the present study, a deep second‑degree burn rat model was used to investigate the burn wound healing properties of aqueous extract of maggots (MAE). The anti‑inflammatory, antioxidative and antibacterial activities were examined. In addition, the protein expression levels of Akt, vascular endothelial growth factor A (VEGFA) and nuclear factor‑κB (NF‑κB) were detected by western blotting...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944884/antioxidant-and-anti%C3%A2-inflammatory-effects-of-dhk%C3%A2-medicated-serum-on-high-glucose%C3%A2-induced-injury-in-endothelial-cells
#3
Ziyang Zhang, Wenpei Chen, Yandong Wang, Tianqin Xiong, Chenghao Zhou, Xiaolan Yao, Baoqin Lin
It has been shown that oxidative damage and inflammation caused by hyperglycemia in endothelial cells are key factors triggering diabetic vascular complications. The aim of the present study was to investigate the antioxidant and anti‑inflammatory effects of Danhong Huayu Koufuye (DHK)‑medicated serum on high glucose (HG)‑induced injury in endothelial cells, and examine its underlying mechanisms. EA. hy926 cells were treated with normal glucose, HG, or HG with DHK‑medicated serum. Cell viability was assessed using the MTT method...
September 21, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944849/celastrol-alleviates-angiotensin-ii%C3%A2-mediated-vascular-smooth-muscle-cell-senescence-via-induction-of-autophagy
#4
Xian-Jie Xu, Wei-Bo Zhao, Shi-Bin Feng, Cheng Sun, Qiang Chen, Bing Ni, Hou-Yuan Hu
Reactive oxygen species (ROS) production has been implicated in the promotion of cellular senescence. Celastrol, a quinone methide triterpenoid isolated from the Celastraceae family, exerts antioxidant effects and enhances autophagy in various cell types. Since autophagy serves an important role in regulating ROS, it was hypothesized that the antioxidant effect of celastrol is via enhanced autophagy, thus inhibiting cell senescence. Therefore, the present study used a Senescence β‑Galactosidase Staining kit, western blot analysis and cell cycle analysis to investigate whether celastrol alleviates angiotensin (Ang) II‑induced cellular senescence by upregulating autophagy in vascular smooth muscle cells (VSMCs)...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944844/h2o2-induces-caveolin%C3%A2-1-degradation-and-impaired-mitochondrial-function-in-e11-podocytes
#5
Ya-Hui Chen, Wei-Wen Lin, Chin-San Liu, Shih-Li Su
Increased intercellular reactive oxygen species (ROS) levels are the major cause of podocyte injury with proteinuria. Caveolin‑1 (CAV‑1) is an essential protein component of caveolae. CAV‑1 participates in signal transduction and endocytic trafficking. Recent research has indicated that CAV‑1 regulates oxidative stress‑induced pathways. The present study used hydrogen peroxide (H2O2) at nontoxic concentrations to elevate the level of ROS in E11 podocytes. Treatment with 500 and 1,000 µM H2O2 for 1 h significantly reduced CAV‑1 expression levels...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944838/effect-of-antioxidant-of-bamboo-leaves-on-gene-expression-associated-with-mouse-embryonic-fibroblast-reproduction-and-embryonic-development
#6
Feng Yu, Xiaowei Qian, Zhanghui Zeng, Xiaoli Zhao, Rong Hou, Zhihe Zhang, Hongwu Bian, Ning Han, Junhui Wang, Muyuan Zhu
Antioxidant of bamboo leaves (AOB) was certified to be a natural antioxidant by the Chinese Ministry of Health in 2003. However, the effects of AOB on animal reproductive and developmental functions remain unclear. The present study aimed to investigate the effects of different concentrations of AOB on mouse embryonic fibroblast (MEF) cells, and to examine the underlying molecular mechanism through which AOB affects the proliferation and apoptosis of MEFs. MEFs prepared from individual embryos were treated with various dosages of AOB...
September 18, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944806/egg-derived-bioactive-peptides-with-ace-inhibitory-properties-a-literature-update
#7
REVIEW
Charlotte Grootaert, Bea Matthijs, Stefan Voorspoels, Sam Possemiers, Guy Smagghe, John Van Camp
Egg proteins contain a wide set of peptide sequences which have an impact on cardiovascular health. Their modes-of-action involve, among others, the inhibition of angiotensin-converting enzyme (ACE) and antioxidant and anti-inflammatory properties. In this review, we focus particularly on ACE-inhibition and discuss recent findings in: (i) production methods for egg protein-derived ACE-inhibitory peptides, (ii) in vitro functionality of these peptides, (iii) their intestinal digestion and absorption in order to reach the target tissue, (iv) the impact of ACE-inhibitory egg-derived peptides in vivo and (v) future perspectives for the implementation of egg-derived ACE-inhibitory peptides as functional foods...
September 25, 2017: Food & Function
https://www.readbyqxmd.com/read/28944695/evaluation-of-eco-friendly-compounds-in-the-manufacturing-of-antibacterial-papers
#8
Parvaneh Narchin, Ahmadreza Saraeyan, Elyas Afra
The papers have a porous structure which can be a suitable medium for the growth of bacteria. Therefore, in the sanitary papers, creation of a suitable antibacterial property is necessary. In this way, the plant extracts were prepared using solid-liquid extraction method from the Rosmarinus officinalis, Olea europaea, Mentha spicata and Punica granatum. Relatively, the total phenol and flavonoid contents were determined according to colorimetric method. Their antioxidant activity was evaluated using DPPH method...
September 25, 2017: Natural Product Research
https://www.readbyqxmd.com/read/28944425/effects-of-physiological-nitric-oxide-donor-on-oxidative-metabolism-in-rat-blood
#9
A K Martusevich, A V Davydyuk, A A Martusevich, L K Kovaleva
The effects of exogenous dinitrosyl iron complexes with glutathione ligands on the parameters of oxidative metabolism in the rat blood are studied. The intensity of LPO, total antioxidant activity, and MDA level in the plasma are compared in rats receiving intraperitoneal injections of saline without and with dinitrosyl iron complexes in various concentrations (0.15, 0.30, 0.45, and 0.60 mM). Glutathione-containing dinitrosyl iron complexes are characterized by antioxidant effect that non-linearly depended of the dose with optimum at 0...
September 25, 2017: Bulletin of Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28944407/oral-thymoquinone-administration-ameliorates-the-effect-of-cisplatin-on-brush-border-membrane-enzymes-energy-metabolism-and-redox-status-in-rat-kidney
#10
Zeba Farooqui, Faaiza Shahid, Subuhi Abidi, Iqbal Parwez, Farah Khan
Therapeutic use of cisplatin (CP), an effective anticancer drug, is limited by dose dependent nephrotoxicity. Thymoquinone (TQ), the major Nigella sativa seed oil constituent has been shown to prevent progression of various renal disorders. The present study investigates the protective effect of TQ on CP-induced nephrotoxicity. Rats were divided into six groups viz. control, CP, CPTQ1, CPTQ2, CPTQ3, and TQ alone group. Animals in CP and TQ combination groups were administered TQ (0.5, 1.5, and 3 mg/kg bwt, orally) with single intraperitoneal dose of CP (6 mg/kg bwt)...
September 24, 2017: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/28943882/root-damage-under-alkaline-stress-is-associated-with-reactive-oxygen-species-accumulation-in-rice-oryza-sativa-l
#11
Hui Zhang, Xiao-Long Liu, Rui-Xue Zhang, Hai-Yan Yuan, Ming-Ming Wang, Hao-Yu Yang, Hong-Yuan Ma, Duo Liu, Chang-Jie Jiang, Zheng-Wei Liang
Alkaline stress (high pH) severely damages root cells, and consequently, inhibits rice (Oryza sativa L.) seedling growth. In this study, we demonstrate the accumulation of reactive oxygen species (ROS) in root cells under alkaline stress. Seedlings of two rice cultivars with different alkaline tolerances, 'Dongdao-4' (moderately alkaline-tolerant) and 'Jiudao-51' (alkaline-sensitive), were subjected to alkaline stress simulated by 15 mM sodium carbonate (Na2CO3). Alkaline stress greatly reduced seedling survival rate, shoot and root growth, and root vigor...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28943767/relationships-between-antioxidants-and-quality-characteristics-from-velvet-antlers-of-formosan-sambar-deer
#12
Shih-Lin Cheng, You-Ling Jian, Chih-Ming Chen, Bing-Tsan Liu
The quality characteristics of velvet antlers obtained from Formosan sambar deer (Cervus unicolor Swinhoi) (SDVA), harvested from 63 to 81 d during the velvet antler growth period, were evaluated by investigating the relationships between antioxidant levels; including content, activity, and content/activity ratios, and physical properties; including shear force values, color, and Ca content. The hardness of samples from base velvet antler sections increased, and that the color of these samples tended to become reddish-yellow (redder and more yellow), suggesting that the Ca content in the base section of the sample was not ossified yet...
2017: Korean Journal for Food Science of Animal Resources
https://www.readbyqxmd.com/read/28943754/pinus-densiflora-bark-extract-prevents-selenite-induced-cataract-formation-in-the-lens-of-sprague-dawley-rat-pups
#13
Jun Kim, Se-Young Choung
PURPOSE: Rat pups treated with sodium selenite are typically used as an in vivo model to mimic age-related nuclear cataract. Reactive oxygen species (ROS) production, lipid peroxidation, reduction of antioxidant enzymes, crystalline proteolysis, and apoptosis are considered factors that contribute to pathogenesis of age-related nuclear cataract. In the present study, we investigated whether Pinus densiflora bark extract has potential to prevent cataract formation and elucidated the underlying mechanism...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28943597/changes-of-klotho-protein-and-klotho-mrna-expression-in-a-hydroxy-l-proline-induced-hyperoxaluric-rat-model
#14
Orapun Jaturakan, Chollada Buranakarl, Thasinas Dissayabutra, Narongsak Chaiyabutr, Anusak Kijtawornrat, Anudep Rungsipipat
Klotho protein is recognized as having a renoprotective effect and is used as a biomarker for kidney injury. We investigated the level of Klotho protein in hyperoxaluria-induced kidney injury and the effects of vitamin E (Vit E) and vitamin C (Vit C) supplementation. Hyperoxaluria was induced by feeding 2% (w/v) Hydroxy-L-proline (HLP) in the drinking water for 21 days. Rats were divided into 5 groups; control (Group 1, n=7), HLP treated rats that received nothing else (Group 2, n=7), Vit E (Group 3, n=6), Vit C (Group 4, n=6) and both Vit E and Vit C (Group 5, n=7)...
September 23, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28943456/permethrin-pesticide-induces-nurr1-up-regulation-in-dopaminergic-cell-line-is-the-pro-oxidant-effect-involved-in-toxicant-neuronal-damage
#15
Laura Bordoni, Donatella Fedeli, Cinzia Nasuti, Melania Capitani, Dennis Fiorini, Rosita Gabbianelli
The mechanisms associated to the development of neurodegeneration due to pesticide exposure are not clear yet. In this study we evaluated how permethrin pesticide (PERM) can influence the Nurr1 gene and protein expression, and if a pro-oxidant activity of the pesticide contributes to up-regulation of Nurr1 in a dopaminergic cell line. Incubation of PC12 cells with 1μM PERM for 72h, leads to over expression of Nurr1 gene. This effect occurs with both corn oil and extra virgin olive oil (EVO) used to solubilize the toxicant...
September 21, 2017: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
https://www.readbyqxmd.com/read/28943392/an-integrative-analysis-of-chemically-induced-cirrhosis-associated-hepatocarcinogenesis-histological-biochemical-and-molecular-features
#16
Guilherme Ribeiro Romualdo, Tony Fernando Grassi, Renata Leme Goto, Mariana Baptista Tablas, Lucas Tadeu Bidinotto, Ana Angélica Henrique Fernandes, Bruno Cogliati, Luís Fernando Barbisan
This study aimed the integrative characterization of morphological, biochemical and molecular features of chemically-induced cirrhosis-associated hepatocarcinogenesis. Thus, male Wistar rats were submitted to a diethylnitrosamine (DEN)/thioacetamide (TAA)-induced model. Liver tissue was processed for global gene expression, histopathological and collagen evaluations; as well as immunohistochemical and oxidative stress analysis. Gene Ontology and functional analysis showed the upregulation of extracellular matrix deposition genes, such as collagen type I alpha 1 and 2 (Col1α1 and Col1α2) and tissue inhibitor of metalloproteinase 1 and 2 genes (Timp1 and Timp2)...
September 21, 2017: Toxicology Letters
https://www.readbyqxmd.com/read/28943290/anti-inflammatory-and-anti-arthritic-properties-of-naringenin-via-attenuation-of-nf-%C3%AE%C2%BAb-and-activation-of-the-heme-oxygenase-%C3%AF-ho%C3%AF-1-related-factor-2-pathway
#17
Rong Fan, Tong Pan, An-Li Zhu, Mei-Hong Zhang
BACKGROUND: Naringenin, a bioflavonoid present in various species of citrus fruit, tomatoes and grapes, has been shown to have various pharmacological effects. We evaluated the anti-arthritic potential of naringenin in formaldehyde-induced inflammation and complete Freund's adjuvant (CFA)-induced arthritis. METHODS: For both evaluations, rats were divided into groups of six. Different doses of naringenin (5, 10 and 20mg/kg) were used in the models. Body weight and the arthritic index were assessed...
April 13, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28943111/relationship-between-higher-serum-selenium-level-and-adverse-blood-lipid-profile
#18
Wen Ju, Mei Ji, Xia Li, Zhe Li, Guanrui Wu, Xiaofeng Fu, Xiaomei Yang, Xibao Gao
BACKGROUND: As the key component of glutathione peroxidase with unique antioxidant properties, selenium has been considered to play an important part on lipid metabolism. However, the associations of serum selenium concentrations with lipid concentrations and dyslipidemia are still controversial. METHODS: We analyzed cross-sectional data including serum selenium levels, lipid concentrations and other related indexes of 8198 rural Chinese. Serum selenium was measured by inductively coupled plasma mass spectrometry, and total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-c) and low density lipoprotein-cholesterol (LDL-c) of serum were measured with kits...
September 4, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28943110/therapies-for-mitochondrial-diseases-and-current-clinical-trials
#19
REVIEW
Ayman W El-Hattab, Ana Maria Zarante, Mohammed Almannai, Fernando Scaglia
Mitochondrial diseases are a clinically and genetically heterogeneous group of disorders that result from dysfunction of the mitochondrial oxidative phosphorylation due to molecular defects in genes encoding mitochondrial proteins. Despite the advances in molecular and biochemical methodologies leading to better understanding of the etiology and mechanism of these diseases, there are still no satisfactory therapies available for mitochondrial disorders. Treatment for mitochondrial diseases remains largely symptomatic and does not significantly alter the course of the disease...
September 18, 2017: Molecular Genetics and Metabolism
https://www.readbyqxmd.com/read/28943106/at2-receptor-agonist-compound-21-a-silver-lining-for-diabetic-nephropathy
#20
REVIEW
Anuradha Pandey, Anil Bhanudas Gaikwad
The currently available therapies for diabetic nephropathy, one of the leading causes of renal failure globally are based on inhibition of renin angiotensin system. However, recently, the focus has shifted towards activation of its protective arm rather than the inhibition of deteriorative axis, using specific agonists. Compound 21 (C21), a novel non-peptide Angiotensin II type 2 receptor (AT2) agonist, recently granted orphan drug status for the treatment of a rare disease, idiopathic pulmonary fibrosis has also shown a potent anti-inflammatory, anti-fibrotic, antioxidant and anti-apoptotic potential in various diseases including heart failure, myocardial infarction, chronic inflammatory diseases, and neurological diseases such as ischemic stroke...
September 21, 2017: European Journal of Pharmacology
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