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Testosterone androgen cholesterol

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https://www.readbyqxmd.com/read/28086774/androgenic-effects-of-aqueous-and-methanolic-extracts-of-ficus-asperifolia-in-male-wistar-rats
#1
Pierre Watcho, Hermine Meli Watio, Modeste Wankeu-Nya, Esther Ngadjui, Patrick Deeh Defo, Pepin Alango Nkeng-Efouet, Telesphore Benoit Nguelefack, Albert Kamanyi
BACKGROUND: Androgen deficiency is a clinical syndrome resulting from the inability of the testes to produce physiological levels of testosterone due to a disturbance occurring at one or more levels of the hypothalamic-pituitary-testicular axis. The present study was undertaken to evaluate the androgenic properties of aqueous and methanolic extracts of Ficus asperifolia on normal and castrated immature rats. METHODS: Normal rats were treated either per os with aqueous or methanolic extract of Ficus asperifolia (100 mg/kg or 500 mg/kg b...
January 13, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28058854/effect-of-metformin-on-clinical-metabolic-and-endocrine-outcomes-in-women-with-polycystic-ovary-syndrome-a-meta-analysis-of-randomized-controlled-trial
#2
Roshni Patel, Gaurang Shah
OBJECTIVE: Metformin has been used as a treatment option for polycystic ovary syndrome (PCOS) since 1994; however, more than a hundred randomized clinical trials have reported controversial results regarding the efficacy of metformin in PCOS. This could be due to the small sample size and high variability in methodology between studies. The objective of the present meta-analysis was to determine the effect of metformin on clinical, metabolic, endocrine outcomes as compared to placebo in PCOS women...
January 6, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28008755/an-exploratory-analysis-of-the-association-between-levels-of-hormones-implied-in-steroid-biosynthesis-and-activity-of-abiraterone-in-patients-with-metastatic-castration-resistant-prostate-cancer
#3
Valentina Bertaglia, Marcello Tucci, Francesca Vignani, Consuelo Buttigliero, Emiliano Aroasio, Alfredo Berruti, Giorgio V Scagliotti, Massimo DI Maio
BACKGROUND: Abiraterone acetate, approved for patients with metastatic castration-resistant prostate cancer (mCRPC), blocks androgen byosinthesis. We aimed to describe changes determined by abiraterone in hormones implied in steroid biosynthesis, exploring association between hormonal levels and drug activity. METHODS: Patients with mCRPC, receiving standard abiraterone + prednisone after docetaxel failure, were studied. We determined serum levels of progesterone, 17OH-progesterone, cortisol, ACTH, DHEA-sulphate, androstenedione, testosterone, sex hormone-binding globulin, aldosterone, plasma renin activity, and cholesterol, baseline and every 12 weeks...
December 22, 2016: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/27999286/testosterone-deficiency-induces-changes-of-the-transcriptomes-of-visceral-adipose-tissue-in-miniature-pigs-fed-a-high-fat-and-high-cholesterol-diet
#4
Lifan Zhang, Yueqin Cai, Shengjuan Wei, Yun Ling, Liang Zhu, Dongfeng Li, Zhaowei Cai
Testosterone deficiency causes fat deposition, particularly in visceral fat, and its replacement might reverse fat accumulation, however, the underlying mechanisms of such processes under diet-induced adiposity are largely unknown. To gain insights into the genome-wide role of androgen on visceral adipose tissue (VAT), RNA-Seq was used to investigate testosterone deficiency induced changes of VAT in miniature pigs fed a high-fat and high-cholesterol (HFC) diet among intact male pigs (IM), castrated male pigs (CM), and castrated male pigs with testosterone replacement (CMT) treatments...
December 16, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27927075/soy-isoflavones-exert-beneficial-effects-on-letrozole-induced-rat-polycystic-ovary-syndrome-pcos-model-through-anti-androgenic-mechanism
#5
Ravi Kumar Rajan, Siva Selva Kumar M, Bhaskar Balaji
CONTEXT: Soy is the main source of phytoestrogens, which has long been used as traditional food. One major subtype of phytoestrogens includes isoflavones and they are scientifically validated for their beneficial actions on many hormone-dependent conditions. OBJECTIVE: The present study examines the effect of soy isoflavones on letrozole-induced polycystic ovary syndrome (PCOS) rat model. MATERIALS AND METHODS: PCOS was induced in Sprague-Dawley rats with of 1 mg/kg letrozole, p...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27923166/a-comparative-systematic-review-of-yasmin-drospirenone-pill-versus-standard-treatment-options-for-symptoms-of-polycystic-ovary-syndrome
#6
REVIEW
Jing Li, Jing Ren, Wenxia Sun
OBJECTIVES: To systematically review the impact of Yasmin (drospirenone pill) compares with other standard treatments for symptoms of Polycystic Ovary Syndrome (PCOS). STUDY DESIGN: The relevant studies of the randomized controlled trials in women with PCOS treated with drospirenone were retrieved and the systematic evaluation was conducted. RESULTS: Eighteen articles were included. Compared with drospirenone (DRSP) monotherapy, DRSP plus metformin was better in reducing body mass index (BMI), luteinizing hormone (LH) and low-density lipoprotein cholesterol (LDL-C)...
November 16, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27797332/-experimental-study-of-the-influence-of-recombinant-human-lactoferrin-on-the-levels-of-androgens-and-basic-parameters-of-lipid-and-protein-metabolism
#7
Yu A Rudnichenko, V S Lukashevich, I V Zalutsky
System administration of human recombinant lactoferrin per os to rats for 2,5 months increased serum and testicular levels of total testosterone. The data correlated with the increase in free testosterone levels. These changes were accompanied by an increase of concentrations of steroidogenesis substrates (cholesterol, progesterone, and 17-OH progesterone) and a decrease of the estradiol content in blood serum. This resulted in the 3.6-3.8-fold increase of the testosterone/estradiol index. Basic parameters of lipid and protein were also studied...
July 2016: Biomedit︠s︡inskai︠a︡ Khimii︠a︡
https://www.readbyqxmd.com/read/27672740/paracrine-sonic-hedgehog-signaling-contributes-significantly-to-acquired-steroidogenesis-in-the-prostate-tumor-microenvironment
#8
Amy A Lubik, Mannan Nouri, Sarah Truong, Mazyar Ghaffari, Hans H Adomat, Eva Corey, Michael E Cox, Na Li, Emma S Guns, Parvin Yenki, Steven Pham, Ralph Buttyan
Despite the substantial benefit of androgen deprivation therapy (ADT) for metastatic prostate cancer, patients often progress to castration-resistant disease (CRPC) that is more difficult to treat. CRPC is associated with renewed androgen receptor activity in tumor cells and restoration of tumor androgen levels through acquired intratumoral steroidogenesis (AIS). Although prostate cancer (PCa) cells have been shown to have steroidogenic capability in vitro, we previously found that benign prostate stromal cells (PrSCs) can also synthesize testosterone (T) from an adrenal precursor, DHEA, when stimulated with a hedgehog (Hh) pathway agonist, SAG...
January 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27488580/testosterone-differentially-regulates-targets-of-lipid-and-glucose-metabolism-in-liver-muscle-and-adipose-tissues-of-the-testicular-feminised-mouse
#9
Daniel M Kelly, Samia Akhtar, Donna J Sellers, Vakkat Muraleedharan, Kevin S Channer, T Hugh Jones
Testosterone deficiency is commonly associated with obesity, metabolic syndrome, type 2 diabetes and their clinical consequences-hepatic steatosis and atherosclerosis. The testicular feminised mouse (non-functional androgen receptor and low testosterone) develops fatty liver and aortic lipid streaks on a high-fat diet, whereas androgen-replete XY littermate controls do not. Testosterone treatment ameliorates these effects, although the underlying mechanisms remain unknown. We compared the influence of testosterone on the expression of regulatory targets of glucose, cholesterol and lipid metabolism in muscle, liver, abdominal subcutaneous and visceral adipose tissue...
November 2016: Endocrine
https://www.readbyqxmd.com/read/27436076/effects-of-8-year-treatment-of-long-acting-testosterone-undecanoate-on-metabolic-parameters-urinary-symptoms-bone-mineral-density-and-sexual-function-in-men-with-late-onset-hypogonadism
#10
Sompol Permpongkosol, Kalayanee Khupulsup, Supatra Leelaphiwat, Sarawan Pavavattananusorn, Supranee Thongpradit, Thanom Petchthong
INTRODUCTION: The long-term effects of long-acting testosterone undecanoate (TU) and androgen receptor CAG repeat lengths in Thai men with late-onset hypogonadism (LOH) have not been reported. AIM: To analyze the 8-year follow-up effects of intramuscular TU therapy on metabolic parameters, urinary symptoms, bone mineral density, and sexual function and investigate CAG repeat lengths in men with LOH. METHODS: We reviewed the medical records of 428 men with LOH who had been treated with TU and 5 patients were diagnosed with prostate cancer during TU therapy...
August 2016: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/27423106/changes-in-hormone-and-lipid-levels-in-male-patients-with-focal-seizures-when-switched-from-carbamazepine-to-lacosamide-as-adjunctive-treatment-to-levetiracetam-a-small-phase-iiib-prospective-multicenter-open-label-trial
#11
Christian E Elger, Michael Rademacher, Christian Brandt, Sami Elmoufti, Peter Dedeken, Klaus Eckhardt, Frank Tennigkeit, Marc De Backer
Treatment with enzyme-inducing antiepileptic drugs (AEDs) such as carbamazepine (CBZ) can lead to changes in reproductive, endocrine, and lipid parameters, resulting in clinical symptoms for some patients. Previous studies indicate that these changes can be reversed by switching to a nonenzyme-inducing AED. Lacosamide is a newer-generation AED, not known to induce or strongly inhibit cytochrome P450 (CYP450) enzymes. In this phase IIIb, prospective, multicenter, open-label, single-arm trial (NCT01375374), the serum concentrations of CYP-related reproductive hormones, thyroid hormones, and lipids were assessed in otherwise healthy male patients with focal seizures (N=11), before and after a switch from CBZ (600-1200mg/day at baseline) to lacosamide (target dose: 400mg/day by the end of titration) as adjunctive treatment to the nonenzyme-inducing AED levetiracetam (LEV, stable dosage of >1000mg/day throughout)...
September 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27388148/effects-of-butylated-hydroxyanisole-on-the-steroidogenesis-of-rat-immature-leydig-cells
#12
Xiaoheng Li, Shuyan Cao, Baiping Mao, Yanfang Bai, Xiaomin Chen, Xiudi Wang, Ying Wu, Linxi Li, Han Lin, Qingquan Lian, Ping Huang, Ren-Shan Ge
Butylated hydroxyanisole (BHA) is a synthetic antioxidant used for food preservation. Whether BHA affects testosterone biosynthesis is still unclear. The effects of BHA on the steroidogenesis in rat immature Leydig cells were investigated. Rat immature Leydig cells were isolated from 35-old-day rats and cultured with BHA (50 μM) for 3 h in combination with 22R-OH-cholesterol, pregnenolone, progesterone, androstenedione, testosterone or dihydrotestosterone, and the concentrations of 5α-androstanediol and testosterone in the media were measured...
September 2016: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/27251588/androgen-receptor-ggc-repeat-might-be-more-involved-than-cag-repeat-in-the-regulation-of-the-metabolic-profile-in-men
#13
Giacomo Tirabassi, Melissa Cutini, Benedetta Beltrami, Nicola Delli Muti, Andrea Lenzi, Giancarlo Balercia
The influence of androgen receptor (AR) GGC repeat polymorphism on the metabolic profile of men has been much less studied than the one of CAG tract polymorphism. Therefore, in this study, we looked for the association of GGC and CAG tract with cardiovascular risk factors in men. Ninety-eight men followed by our andrological unit were retrospectively reviewed. Clinical and biochemical parameters on cardiovascular risk were considered. AR CAG and GGC polymorphisms were studied. GGC triplets were found to be positively and significantly correlated with several cardiovascular risk factors...
June 1, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27239195/lipid-profile-in-adolescent-girls-with-type-1-diabetes-mellitus-and-hyperandrogenemia
#14
Agnieszka Zachurzok, Grazyna Deja, Aneta Gawlik, Agnieszka Drosdzol-Cop, Katarzyna Klimek, Ewa Malecka-Tendera
Study Objectives. The study aim was to evaluate whether hyperandrogenemia in adolescent girls with type 1 diabetes mellitus (T1DM) may adversely influence lipid profile. Design and Participants. Lipid levels in 16 diabetic girls with biochemical hyperandrogenemia (T1DM-H) aged 16.3 ± 1.2 years were compared to 38 diabetic girls with normal androgen levels (T1DM-N) aged 15.8 ± 1.2 years. 15 healthy girls served as controls (CG). In all patients, anthropometric measurements were done, and androgens and SHBG were assessed...
2016: International Journal of Endocrinology
https://www.readbyqxmd.com/read/27230625/microscopic-visualization-of-testosterone-in-mouse-testis-by-use-of-imaging-mass-spectrometry
#15
Shuichi Shimma, Henri-Obadja Kumada, Hisanori Taniguchi, Alu Konno, Ikuko Yao, Kyoji Furuta, Tadashi Matsuda, Seiji Ito
Testosterone is one of the androgens synthesized from cholesterol as a precursor in the Leydig cells of testes. Since the ionization efficiency of testosterone in matrix-assisted laser desorption ionization (MALDI) is quite low, visualization of testosterone by using MALDI-imaging mass spectrometry (MALDI-IMS) has been considered difficult. To overcome this problem, we used two types of on-tissue derivatization techniques, which were achieved by pyridine sulfur trioxide and Girard's T (GT) reagent, to introduce a polar group into testosterone molecule with the aim to increase the sensitivity...
May 26, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27185484/developmental-exposure-to-2-3-7-8-tetrachlorodibenzo-p-dioxin-may-alter-lh-release-patterns-by-abolishing-sex-differences-in-gaba-glutamate-cell-number-and-modifying-the-transcriptome-of-the-male-anteroventral-periventricular-nucleus
#16
Javier Del Pino Sans, Kelsey J Clements, Alexander Suvorov, Sudha Krishnan, Hillary L Adams, Sandra L Petersen
Developmental exposure to arylhydrocarbon receptor (AhR) ligands abolishes sex differences in a wide range of neural structures and functions. A well-studied example is the anteroventral periventricular nucleus (AVPV), a structure that controls sex-specific luteinizing hormone (LH) release. In the male, testosterone (T) secreted by the developing testes defeminizes LH release mechanisms; conversely, perinatal AhR activation by 2,3,7,8,-tetrachlorodibenzo-p-dioxin (TCDD) blocks defeminization. To better understand developmental mechanisms altered by TCDD exposure, we first verified that neonatal TCDD exposure in male rats prevented the loss of AVPV GABA/glutamate neurons that are critical for female-typical LH surge release...
August 4, 2016: Neuroscience
https://www.readbyqxmd.com/read/27163357/sex-steroids-sex-hormone-binding-globulin-and-cardiovascular-health-in-men-and-postmenopausal-women-the-rotterdam-study
#17
Loes Jaspers, Klodian Dhana, Taulant Muka, Cindy Meun, Jessica C Kiefte-de Jong, Albert Hofman, Joop S E Laven, Oscar H Franco, Maryam Kavousi
CONTEXT: The concept of cardiovascular health was recently introduced. Sex steroids and sex hormone-binding globulin (SHBG) influence different health domains, but no studies assessed their role in cardiovascular health. OBJECTIVE: To assess the association between estradiol (E2), testosterone (T), SHBG, and free androgen index (FAI) with cardiovascular health. DESIGN, SETTING, AND PARTICIPANTS: Analyses included 1647 men (68.6 y) and 1564 naturally postmenopausal women (69...
July 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27137100/cyp3a-deficiency-enhances-androgen-receptor-activity-and-cholesterol-synthesis-in-the-mouse-prostate
#18
Mari Hashimoto, Kaoru Kobayashi, Mana Yamazaki, Yasuhiro Kazuki, Shoko Takehara, Mitsuo Oshimura, Kan Chiba
Testosterone regulates cellular functions in the prostate through activation of the androgen receptor (AR), which may enhance expression levels of cholesterogenic enzymes through activation of sterol regulatory element-binding protein2 (SREBP2). Because testosterone is inactivated to 6β-hydroxytestosterone by cytochrome P450 3A (CYP3A), we examined the effects of Cyp3a deficiency on circulating testosterone levels and its effects on activation of the AR and expression levels of cholesterogenic enzymes in the prostate using Cyp3a-knockout (Cyp3a(-/-)) mice...
October 2016: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/27076501/non-alcoholic-fatty-liver-disease-is-associated-with-insulin-resistance-and-lipid-accumulation-product-in-women-with-polycystic-ovary-syndrome
#19
D Macut, K Tziomalos, I Božić-Antić, J Bjekić-Macut, I Katsikis, E Papadakis, Z Andrić, D Panidis
STUDY QUESTION: What are the most relevant factors associated with non-alcoholic fatty liver disease (NAFLD) in women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Insulin resistance (IR) and lipid accumulation product (LAP) are independently associated with NAFLD in PCOS. WHAT IS KNOWN ALREADY: Obesity and IR are frequently present in both women with PCOS and subjects having NAFLD. The coexistence of PCOS and NAFLD might synergistically increase the risk for both type 2 diabetes (T2DM) and cardiovascular disease (CVD)...
June 2016: Human Reproduction
https://www.readbyqxmd.com/read/27052235/-sex-and-gender-aspects-in-regard-to-clinical-practice-recommendations-for-pre-diabetes-and-diabetes
#20
REVIEW
Alexandra Kautzky-Willer, Heidemarie Abrahamian, Raimund Weitgasser, Peter Fasching, Fritz Hoppichler, Monika Lechleitner
Metabolic diseases dramatically affect life of men and women from infancy up to old age and are a major challenge for clinicians. Health professionals are confronted with different needs of women and men. This article aims at an increase of gender awareness and the implementation of current knowledge of gender medicine in daily clinical practice with regard to pre-diabetes and diabetes. Sex and gender affect screening and diagnosis of metabolic diseases as well as treatment strategies and outcome. Impaired glucose and lipid metabolism, regulation of energy balance and body fat distribution are related to steroid hormones and therefore impose their influence on cardiovascular health in both men and women...
April 2016: Wiener Klinische Wochenschrift
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