Sin Yi Lee, Hirotaka Shoji, Aki Shimozawa, Hirofumi Aoyagi, Yoshiaki Sato, Kazuya Tsumagari, Mika Terumitsu, Haruhiko Motegi, Kensuke Okada, Koji Sekiguchi, Junro Kuromitsu, Jin Nakahara, Tsuyoshi Miyakawa, Daisuke Ito
BACKGROUND AND OBJECTIVES: Anti-IgLON5 disease is an autoimmune neurodegenerative disorder characterized by various phenotypes, notably sleep and movement disorders and tau pathology. Although the disease is known to be associated with the neuronal cell adhesion protein IgLON5, the physiologic function of IgLON5 remains elusive. There are conflicting views on whether autoantibodies cause loss of function, activation of IgLON5, or inflammation-associated neuronal damage, ultimately leading to the disease...
May 2024: Neurology® Neuroimmunology & Neuroinflammation