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https://www.readbyqxmd.com/read/28927263/molecular-and-cellular-basis-of-neurodegeneration-in-alzheimer-s-disease
#1
Sangyun Jeong
The most common form of senile dementia is Alzheimer's disease (AD), which is characterized by the extracellular deposition of amyloid beta-peptide (Abeta) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson's disease, and Pick's disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than Abeta plaque accumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD...
September 20, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/28927231/leadership-succession-future-proofing-pipelines
#2
Saul Taylor, Howard Youngs
The challenges in deaf education illustrate the requirement and importance of leadership in this specialized field. The significant and impending talent depletion unfolding as baby-boomers retire, positions leadership succession planning as a strategic issue. This mixed methods study is the first of its kind in New Zealand. The aim is to understand leadership demographics and assumptions to determine the need for strategic succession planning to identify and address leaky pipelines. The findings from 82% of the deaf education workforce through a questionnaire and interviews with seven senior leaders reveal that senior leaders do not appear aware of four key areas that dissuade and shrink the pool of potential leadership aspirants...
September 12, 2017: Journal of Deaf Studies and Deaf Education
https://www.readbyqxmd.com/read/28927229/creation-and-evaluation-of-a-laboratory-administration-curriculum-for-pathology-residents
#3
Jeannette Guarner, Charles E Hill, Timothy Amukele
Objectives: A clinical laboratory management (CLM) curriculum that can objectively assess the Accreditation Council for Graduate Medical Education pathology systems-based practice milestones and can provide consistent resident training across institutions is needed. Methods: Faculty at Emory University created a curriculum that consists of assay verification exercises and interactive, case-based online modules. Beta testing was done at Emory University and Johns Hopkins...
September 11, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28927213/ten-step-minimally-invasive-spine-lumbar-decompression-and-dural-repair-through-tubular-retractors
#4
Mohamed Abdelatif Boukebir, Connor David Berlin, Rodrigo Navarro-Ramirez, Tim Heiland, Karsten Schöller, Cameron Rawanduzy, Sertaç Kirnaz, Ajit Jada, Roger Härtl
BACKGROUND: Minimally invasive spine (MIS) surgery utilizing tubular retractors has become an increasingly popular approach for decompression in the lumbar spine. However, a better understanding of appropriate indications, efficacious surgical techniques, limitations, and complication management is required to effectively teach the procedure and to facilitate the learning curve. OBJECTIVE: To describe our experience and recommendations regarding tubular surgery for lumbar disc herniations, foraminal compression with unilateral radiculopathy, lumbar spinal stenosis, synovial cysts, and dural repair...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28927160/education-of-informatics-professionals-and-development-of-electronic-information-resources-for-clinicians-patients-health-scientists-and-study-participants
#5
Lucila Ohno-Machado
No abstract text is available yet for this article.
July 1, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28927014/green-space-and-depression-during-pregnancy-results-from-the-growing-up-in-new-zealand-study
#6
Vikram Nichani, Kim Dirks, Bruce Burns, Amy Bird, Cameron Grant
Background: Antenatal depression is an important contributor to poor maternal health experienced by some women. This study aimed to determine whether exposure to green space during pregnancy is associated with less depression, and whether this association is moderated by relevant factors, such as age, education, self-identified ethnicity, physical activity, residential rurality, and socioeconomic status. Methods: Health data were sourced from the cohort study "Growing Up in New Zealand" comprised of 6772 participants...
September 18, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28927002/predicting-variation-of-dna-shape-preferences-in-protein-dna-interaction-in-cancer-cells-with-a-new-biophysical-model
#7
Kirill Batmanov, Junbai Wang
DNA shape readout is an important mechanism of transcription factor target site recognition, in addition to the sequence readout. Several machine learning-based models of transcription factor-DNA interactions, considering DNA shape features, have been developed in recent years. Here, we present a new biophysical model of protein-DNA interactions by integrating the DNA shape properties. It is based on the neighbor dinucleotide dependency model BayesPI2, where new parameters are restricted to a subspace spanned by the dinucleotide form of DNA shape features...
September 18, 2017: Genes
https://www.readbyqxmd.com/read/28926990/implementing-a-health-and-wellbeing-programme-for-children-in-early-childhood-a-preliminary-study
#8
Karen Munday, Megan Wilson
In New Zealand, there is a high prevalence of childhood poverty and food insecurity, which can impact a family's ability to provide high quality, nutrient dense foods for their children. In an attempt to increase the quality of the food consumed by children attending a decile two (low socio-economic) kindergarten and to address food insecurity issues, an educational health and wellness initiative, in conjunction with a free lunch programme, was introduced. The impact of the lunches and the effectiveness of the programme were evaluated...
September 18, 2017: Nutrients
https://www.readbyqxmd.com/read/28926989/tech-savvy-beef-cattle-how-heifers-respond-to-moving-virtual-fence-lines
#9
Dana L M Campbell, Jim M Lea, William J Farrer, Sally J Haynes, Caroline Lee
Global Positioning System (GPS)-based virtual fences offer the potential to improve the management of grazing animals. Prototype collar devices utilising patented virtual fencing algorithms were placed on six Angus heifers in a 6.15 hectare paddock. After a "no fence" period, sequential, shifting virtual fences restricted the animals to 40%, 60%, and 80% of the paddock area widthways and 50% lengthways across 22 days. Audio cues signaled the virtual boundary, and were paired with electrical stimuli if the animals continued forward into the boundary...
September 18, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/28926964/poverty-dynamics-and-academic-trajectories-of-children-of-immigrants
#10
Liwei Zhang, Wen-Jui Han
Using Early Childhood Longitudinal Study, Kindergarten Class of 1998-1999 (ECLS-K), we investigated the relationship between poverty and academic trajectories for children in immigrant families in the United States. We used family socioeconomic status (SES) which considers parental education, parental occupation, and family income to define poverty in correspondence with the U.S. federal poverty threshold. Three dimensions of poverty were examined including depth (i.e., not-poor, near-poor, poor or extreme poor), stability (i...
September 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28926931/comparison-of-sociodemographic-and-nutritional-characteristics-between-self-reported-vegetarians-vegans-and-meat-eaters-from-the-nutrinet-sant%C3%A3-study
#11
Benjamin Allès, Julia Baudry, Caroline Méjean, Mathilde Touvier, Sandrine Péneau, Serge Hercberg, Emmanuelle Kesse-Guyot
BACKGROUND: There is a growing trend for vegetarian and vegan diets in many Western countries. Epidemiological evidence suggesting that such diets may help in maintaining good health is rising. However, dietary and sociodemographic characteristics of vegetarians and vegans are not well known. The aim of this cross-sectional study was to describe sociodemographic and nutritional characteristics of self-reported, adult vegetarians and vegans, compared to meat-eaters, from the French NutriNet-Santé study...
September 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28926903/-pharmacotherapy-for-pancreatic-cancer-difficulties-and-prospects
#12
Z H Wang, J Zhou, L Shen
The incidence of pancreatic cancer has been obviously increasing in China over the last decade, however, those patients with advanced pancreatic cancer are suffering from limited treatment strategies and poor clinical prognosis. Chemotherapy improved the overall survival of cases with advanced pancreatic cancer to 8-11 months, and erlotinib brought an additional survival of only 10 days. In this article, the recent progresses on advanced pancreatic cancer were reviewed at the genetic and molecular sub-typing levels, and corresponding clinical transformation studies summarized, some of which have showed encouraging clinical prospects but others have failed due to the complexity of pancreatic cancer...
September 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28926874/-multicenter-epidemiological-investigation-of-hospitalized-elderly-young-and-middle-aged-patients-with-severe-burn
#13
Y Tang, L X Wang, W G Xie, Z A Shen, G H Guo, J J Chen, C M Han, L C Ren, Z G Chu, M F Yin, Y Wang, D X Zhang, Y S Huang, J P Zhang
Objective: To compare and analyze the epidemiological characteristics of hospitalized elderly, young and middle-aged patients with severe burn in recent years, so as to provide reference for the prevention and treatment of elderly patients with severe burn. Methods: Relying on the entry system of epidemiological case data and biological sample of severe burn from multicenter in clinic, medical records of patients with severe burn, aged above 18, hospitalized in 8 burn wards from January 2012 to December 2015 were collected...
September 20, 2017: Zhonghua Shao Shang za Zhi, Zhonghua Shaoshang Zazhi, Chinese Journal of Burns
https://www.readbyqxmd.com/read/28926856/positive-effects-of-promoting-physical-activity-and-balanced-diets-in-a-primary-school-setting-with-a-high-proportion-of-migrant-school-children
#14
Katharina S Weber, Olaf Spörkel, Melina Mertens, Alem Freese, Klaus Strassburger, Boris Kemper, Clemens Bachmann, Knut Diehlmann, Theodor Stemper, Anette E Buyken, Kerstin Ketelhut, Karsten Müssig
Background Children with migration background are at particular risk for overweight. We assessed the effects of a primary school-based initiative targeted at enhancing physical activity and dietary education among children with a high proportion of migration background. Methods Four 3(rd) and 4(th) grade classes (n=70 children, 77% with migration background) participated in a 10-months intervention comprising 2 additional exercise lessons weekly and 10 nutrition lessons per school year. 6 school classes (n=125 children, 65% with migration background) served as control...
September 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28926820/guided-university-debate-effect-of-a-new-teaching-learning-strategy-for-undergraduate-nursing-students
#15
Marta Arrue, Saloa Unanue, David Merida
BACKGROUND: A number of studies have shown that the traditional lecture suffers from limitations in the development of many important competencies such as reasoning ability for nursing professionals. OBJECTIVES: In view of this issue, the authors present a promising alternative to the traditional lecture: the Guided University Debate (GUD). With regard to this aim a teaching-learning sequence of schizophrenia is described based on the GUD. Next, the improvement in the argumentative and declarative knowledge of the students who have participated in the said methodology is demonstrated...
September 5, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28926778/korean-immigrants-don-t-buy-health-insurance-the-influences-of-culture-on-self-employed-korean-immigrants-focusing-on-structure-and-functions-of-social-networks
#16
Hyunsung Oh, Chung Hyeon Jeong
Culture has been pinpointed as a culprit of disparities in health insurance coverage between Korean immigrants and other ethnic groups. This study explored specific mechanisms by which culture influences a decision to buy health insurance among self-employed Korean immigrants living in ethnic enclaves by focusing on the structure and functions of social networks. Between March and June 2015, we recruited 24 Korean immigrant adults (aged 18 or older) who identified as self-employed and being uninsured for substantial periods before 2014 in Southern California...
September 12, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28926775/geographic-and-demographic-correlates-of-autism-related-anti-vaccine-beliefs-on-twitter-2009-15
#17
Theodore S Tomeny, Christopher J Vargo, Sherine El-Toukhy
This study examines temporal trends, geographic distribution, and demographic correlates of anti-vaccine beliefs on Twitter, 2009-2015. A total of 549,972 tweets were downloaded and coded for the presence of anti-vaccine beliefs through a machine learning algorithm. Tweets with self-disclosed geographic information were resolved and United States Census data were collected for corresponding areas at the micropolitan/metropolitan level. Trends in number of anti-vaccine tweets were examined at the national and state levels over time...
September 4, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28926754/training-needs-analysis-the-essential-first-step-for-continuing-professional-development-design
#18
Kathryn Holloway, Kerri Arcus, Georgina Orsborn
Nursing services are expected to be dynamic in response to changing health care needs. This expectation requires the purposeful and effective development of nursing workforce capability through continuing professional development (CPD). An evidence based approach to training needs analysis (TNA) is a highly recommended yet often missing first step in designing a CPD strategy for service improvement. This study used the Hicks-Hennessey questionnaire, a validated TNA tool to inform regional educational commissioning to meet the aims of a community social sector trial (SST) project...
September 5, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28926753/undergraduate-paramedic-student-psychomotor-skills-in-an-obstetric-setting-an-evaluation
#19
Shane Lenson, Jason Mills
The clinical education of paramedic students is an international concern. In Australia, student placements are commonly undertaken with local district ambulance services, however these placements are increasingly limited. Clinical placements within inter-professional settings represent an innovative yet underdeveloped area of investigation. This paper addresses that gap by reporting a pilot evaluation of paramedic student clinical placements in a specialised obstetrics setting. Using a case study approach, the evaluation aimed to identify paramedic psychomotor skills that could be practised in this setting, and understand the nature of key learning events...
August 8, 2017: Nurse Education in Practice
https://www.readbyqxmd.com/read/28926748/association-between-infection-burden-and-adult-height
#20
Dawson W Hedges, Andrew N Berrett, Lance D Erickson, Bruce L Brown, Shawn D Gale
Although highly heritable, adult height is also associated with numerous environmental factors, including exposure to infection. Particularly in developing regions of the world, infection burden appears to slow growth during childhood. Using a large database representative of the US population, we examined associations between adult height and leg length and an infection-burden index based on past exposure to Toxocara species, Toxoplasmosis gondii, cytomegalovirus, hepatitis A, hepatitis B, hepatitis C, herpes simplex virus 1, and herpes simplex virus 2...
September 2, 2017: Economics and Human Biology
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