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https://www.readbyqxmd.com/read/29036854/functional-repertoire-of-interleukin-6-in-the-central-nervous-system-a-review
#1
Klaus Heese
In an aging society with dementia imposing an increasing threat to higher brain cognitive functions, understanding the molecular and cellular events of adult neurogenesis is imperative. Interleukin-6 (IL-6), along with its agonistic acting soluble receptor sIL-6R (the combined proteins are also known as Hyper-IL-6), is a promising cytokine that can support neurogenesis under conditions of neurodegeneration when neuron replacement is needed. In contrast to the previously reported gliogenic effects of activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis, this review summarizes recent studies showing that IL-6 activation can be neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease...
October 9, 2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/29032350/identifying-characteristics-of-the-most-severely-impaired-chronic-pain-patients-treated-at-a-specialized-inpatient-pain-clinic
#2
Eva-Britt Hysing, Lena Smith, Mans Thulin, Rolf Karlsten, Stephen Butler, Torsten Gordh
BACKGROUND AND AIMS: Patients suffering from chronic nonmalignant pain constitute a heterogeneous population in terms of clinical presentation and treatment results. Few data are available about what distinguishes different groups in this huge population of patients with chronic persistent pain (CPP). A subgroup that is poorly studied, consists of the most severely impaired chronic pain patients. At the Uppsala University Hospital Pain Clinic, there is a specialized department accepting the most complex patients for rehabilitation...
October 12, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/28991096/evaluation-of-intervention-fidelity-in-a-multisite-clinical-trial-in-persons-with-multiple-sclerosis
#3
Janet D Morrison, Heather Becker, Alexa K Stuifbergen
BACKGROUND: Careful consideration of intervention fidelity is critical to establishing the validity and reliability of research findings, yet such reports are often lacking in the research literature. It is imperative that intervention fidelity be methodically evaluated and reported to promote the translation of effective interventions into sound evidence-based practice. PURPOSE: The purpose of this article is to explore strategies used to promote intervention fidelity, incorporating examples from a multisite clinical trial, that illustrate the National Institutes of Health Behavior Change Consortium's 5 domains for recommended treatment practices: (1) study design, (2) facilitator training, (3) intervention delivery, (4) intervention receipt, and (5) intervention enactment...
October 5, 2017: Journal of Neuroscience Nursing: Journal of the American Association of Neuroscience Nurses
https://www.readbyqxmd.com/read/28958054/shifting-paradigms-advance-care-planning-for-pain-management-in-older-adults-with-dementia
#4
Staja Star Booker, Rashida D Booker
Ensuring effective pain management is an important quality of life (and death) issue for older adults with dementia, particularly since they are more vulnerable to under-assessment and under-treatment of pain. Yet, pain management decisions are often made by health care providers and caregivers with little to no input on the older adult's with dementia values for pain management. The Institute of Medicine (IOM) has recognized the revolutionary imperative to change the manner in which pain care is planned and coordinated...
April 1, 2017: Gerontologist
https://www.readbyqxmd.com/read/28942767/measuring-the-effect-of-soil-transmitted-helminth-infections-on-cognitive-function-in-children-systematic-review-and-critical-appraisal-of-evidence
#5
Kei Owada, Mark Nielsen, Colleen L Lau, Archie C A Clements, Laith Yakob, Ricardo J Soares Magalhães
Recently the role of soil-transmitted helminth (STH) infections in children's cognitive developmental impairment has been under scrutiny. We conducted a systematic review of the evidence for associations between STH infections and cognitive function of children using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol. We aimed to identify the domains of cognitive function in three age strata (<24months, 24-59months and ≥60months) and critically appraise the general design protocol of the studies, with a focus on the cognitive function measurement tools used...
2017: Advances in Parasitology
https://www.readbyqxmd.com/read/28876140/school-nurses-perceptions-and-experiences-with-an-interprofessional-concussion-management-team-in-the-secondary-school-setting
#6
Cailee E Welch Bacon, Casey D Erickson, Melissa C Kay, Michelle L Weber, Tamara C Valovich McLeod
Following a concussion, both cognitive and physical rest are imperative aspects of injury management. The inclusion of academic adjustments and the formation of an interprofessional concussion management team (ICMT) provide a mechanism to manage academic issues following a concussion. As one of the sole healthcare providers presents during school hours, the school nurse may offer unique insight regarding the infrastructure of an ICMT in the secondary school setting. The purpose of this study was to explore school nurses' perceptions of and experiences with an ICMT for adolescents following a concussion in the secondary school setting...
September 6, 2017: Journal of Interprofessional Care
https://www.readbyqxmd.com/read/28874111/the-fall-in-older-adults-physical-and-cognitive-problems
#7
Bernard Demanze Laurence, Lacour Michel
BACKGROUND: The aging of posture and balance function alters the quality of life in older people and causes serious problems in terms of public health and socio-economic costs for our modern societies. METHOD: This article reviews the various causes of imbalance and dizziness in the elderly, and considers how to prevent falls, and how to rehabilitate a faller subject in order to regain a good quality of life. Two effective ways of intervention are discussed, emphasizing the crucial role of physical activity and cognitive stimulation, classic or using the latest technical advances in virtual reality and video games...
2017: Current Aging Science
https://www.readbyqxmd.com/read/28869910/cognition-in-depression-can-we-thinc-it-better
#8
Bernhard T Baune, Gin S Malhi, Grace Morris, Tim Outhred, Amber Hamilton, Pritha Das, Darryl Bassett, Michael Berk, Philip Boyce, Bill Lyndon, Roger Mulder, Gordon Parker, Ajeet B Singh
BACKGROUND: Cognitive compromise is a common experience for patients with depression and other mood disorders. Depressed patients sustain deficits in working memory and attentional distortions in emotional processing and negative attention biases, which may contribute to maintaining their depressive state. METHODS: The Mood Assessment and Classification (MAC) Committee comprised academic psychiatrists with clinical expertise in the management of mood disorders. The independently convened committee met to discuss contentious aspects of mood disorders diagnosis and assessment with the express aim of informing clinical practice and future research...
January 1, 2018: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28852890/body-representation-in-patients-after-vascular-brain-injuries
#9
Magdalena Razmus
Neuropsychological literature suggests that body representation is a multidimensional concept consisting of various types of representations. Previous studies have demonstrated dissociations between three types of body representation specified by the kind of data and processes, i.e. body schema, body structural description, and body semantics. The aim of the study was to describe the state of body representation in patients after vascular brain injuries and to provide evidence for the different types of body representation...
August 29, 2017: Cognitive Processing
https://www.readbyqxmd.com/read/28822221/brain-plasticity-cognitive-functions-and-neural-stem-cells-a-pivotal-role-for-the-brain-specific-neural-master-gene-srgap2-fam72
#10
Nguyen Thi Thanh Ho, Arne Kutzner, Klaus Heese
Due to an aging society with an increased dementia-induced threat to higher cognitive functions, it has become imperative to understand the molecular and cellular events controlling the memory and learning processes in the brain. Here, we suggest that the novel master gene pair |-SRGAP2-FAM72-| (SLIT-ROBO Rho GTPase activating protein 2 - family with sequence similarity to 72) reveals a new dogma for the regulation of neural stem cell (NSC) gene expression and is a distinctive player in the control of human brain plasticity...
August 28, 2017: Biological Chemistry
https://www.readbyqxmd.com/read/28802929/caregiver-burden-and-the-nonmotor-symptoms-of-parkinson-s-disease
#11
Jon P Hiseman, Robin Fackrell
Parkinson's disease has traditionally been considered as primarily a motor disorder (Chaudhuri & Schapira, 2009). It is clear however that it is the burden of the nonmotor symptomatology which impacts significantly more highly on caregiver burden and quality of life (Benavides, Alberquerque, & Chana-Cuevas, 2013; Martinez-Martin, 2011). As Parkinson's disease advances there is an almost inevitable accrual of nonmotor symptoms alongside the motor aspects of the disease. Patients as their disease progresses require increasing support and this is not infrequently provided by an informal caregiver, most typically a spouse or family member (Martinez-Martin, Forjaz, Frades-Payo, et al...
2017: International Review of Neurobiology
https://www.readbyqxmd.com/read/28792471/comparative-studies-on-behavioral-cognitive-and-biomolecular-profiling-of-icr-c57bl-6-and-its-sub-strains-suitable-for-scopolamine-induced-amnesic-models
#12
Govindarajan Karthivashan, Shin-Young Park, Joon-Soo Kim, Duk-Yeon Cho, Palanivel Ganesan, Dong-Kug Choi
Cognitive impairment and behavioral disparities are the distinctive baseline features to investigate in most animal models of neurodegenerative disease. However, neuronal complications are multifactorial and demand a suitable animal model to investigate their underlying basal mechanisms. By contrast, the numerous existing neurodegenerative studies have utilized various animal strains, leading to factual disparity. Choosing an optimal mouse strain for preliminary assessment of neuronal complications is therefore imperative...
August 9, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28714724/gambling-related-cognition-scale-grcs-are-skills-based-games-at-a-disadvantage
#13
David Lévesque, Serge Sévigny, Isabelle Giroux, Christian Jacques
The Gambling-Related Cognition Scale (GRCS; Raylu & Oei, 2004) was developed to evaluate gambling-related cognitive distortions for all types of gamblers, regardless of their gambling activities (poker, slot machine, etc.). It is therefore imperative to ascertain the validity of its interpretation across different types of gamblers; however, some skills-related items endorsed by players could be interpreted as a cognitive distortion despite the fact that they play skills-related games. Using an intergroup (168 poker players and 73 video lottery terminal [VLT] players) differential item functioning (DIF) analysis, this study examined the possible manifestation of item biases associated with the GRCS...
July 17, 2017: Psychology of Addictive Behaviors: Journal of the Society of Psychologists in Addictive Behaviors
https://www.readbyqxmd.com/read/28701980/depression-and-anxiety-prevention-based-on-cognitive-behavioral-therapy-for-at-risk-adolescents-a-meta-analytic-review
#14
Sanne P A Rasing, Daan H M Creemers, Jan M A M Janssens, Ron H J Scholte
Depression and anxiety disorders are among the most common mental disorders during adolescence. During this life phase, the incidence of these clinical disorders rises dramatically, and even more adolescents suffer from symptoms of depression or anxiety that are just below the clinical threshold. Both clinical and subclinical levels of depression or anxiety symptoms are related to decreased functioning in various areas, such as social and academic functioning. Prevention of depression and anxiety in adolescents is therefore imperative...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28668726/prudence-pleasure-and-cognitive-ageing-configurations-of-the-uses-and-users-of-brain-training-games-within-uk-media-2005-2015
#15
Martyn Pickersgill, Tineke Broer, Sarah Cunningham-Burley, Ian Deary
The use of 'brain training' games is often regarded as relating to wider ideals of self-improvement and youthfulness. Hence, use is intertwined with discourses of 'active' ageing. This paper analyzes how the use and users of brain training games were configured in the UK media, from 2005 to 2015, and examines how notions of active ageing relate to these representations. Game users were rarely constructed solely as gamers, and were more often presented as prudent individuals focused on a serious goal. This configuration related to assumed and enjoined motivations for brain training; specifically, users were commonly framed as seeking to enhance cognition and limit/delay cognitive decline...
August 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28628018/autoimmune-limbic-encephalitis-case-reports
#16
K Kobaidze, A Harrison, Y Burklin, V Patidar, M Riccardi
Limbic encephalitis (LE) is an autoimmune or paraneoplastic disease that affects the medial temporal lobes. The patient will usually present with cognitive impairment, psychiatric changes, and seizures. Autoimmune limbic encephalitis (LE) is a challenging diagnosis as it is not always included in the typical paraneoplastic/autoimmune panels. Anti-GAD antibodies are associated with various disease including type I diabetes mellitus, various autoimmune processes, some neoplastic and infectious diseases. Thus, it is not as specific as some of the antibodies causing LE...
May 2017: Georgian Medical News
https://www.readbyqxmd.com/read/28545363/sleep-wake-patterns-and-cognition-of-older-adults-with-amnestic-mild-cognitive-impairment-amci-a-comparison-with-cognitively-healthy-adults-and-moderate-alzheimer-s-disease-patients
#17
Emma J Wams, Gordon K Wilcock, Russell G Foster, Katharina Wulff
Age-related cognitive impairment and the prevalence of neurodegenerative disease contribute to decreasing quality of life in affected individuals and their families as well as demand considerable societal responsibility. Sleep supports overall brain activity and contributes to both physical and mental health. As a result sleep is an attractive target for exploring ways to promote health in accelerated cognitive aging. The aims of this study were to characterise cognitive performance and sleep-wake behaviour in older adults with different degrees of cognitive impairment...
May 22, 2017: Current Alzheimer Research
https://www.readbyqxmd.com/read/28541234/psychiatric-specialty-training-in-greece
#18
EDITORIAL
M Margariti, V Kontaxakis, D Ploumpidis
The reform and development of psychiatric services require, in addition to financial resources, reserves in specialized human resources. The role of psychiatrists in this process, and at reducing the consequences of mental morbidity is evident. Psychiatrists are required to play a multifaceted role as clinicians, as experts in multidisciplinary team environments and as advisors in the recognition of public needs in mental health issues, as teachers and mentors for students and other health professionals, as researchers in order to enrich our knowledge in the scientific field of psychiatry, and as public health specialists in the development of the mental health services system...
January 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/28509081/interleukin-6-mediated-induced-pluripotent-stem-cell-ipsc-derived-neural-differentiation
#19
Yanuar Alan Sulistio, Han Kyu Lee, Sung Jun Jung, Klaus Heese
In an aging society with an increasing threat to higher brain cognitive functions due to dementia, it becomes imperative to identify new molecular remedies for supporting adult neurogenesis. Interleukin-6 (IL-6) is a promising cytokine that can support neurogenesis under conditions of neurodegeneration, and neuron replacement is eventually possible due to its agonistic acting soluble receptor sIL-6R. Here, we report that activation of the IL-6-signal transducer and activator of transcription 3 (STAT3) axis is neurogenic and has potential therapeutic applications for the treatment of neurodegenerative diseases such as Parkinson's disease (PD)...
May 16, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28499456/role-of-micrornas-in-premature-ovarian-insufficiency
#20
REVIEW
Ying Guo, Junyan Sun, Dongmei Lai
Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. POI could lead to infertility, osteoporosis, cardiovascular disorder, and cognitive dysfunction...
May 12, 2017: Reproductive Biology and Endocrinology: RB&E
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