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https://www.readbyqxmd.com/read/27895528/nurses-perceptions-of-a-pressure-ulcer-prevention-care-bundle-a-qualitative-descriptive-study
#1
Shelley Roberts, Elizabeth McInnes, Marianne Wallis, Tracey Bucknall, Merrilyn Banks, Wendy Chaboyer
BACKGROUND: Pressure ulcer prevention is a critical patient safety indicator for acute care hospitals. An innovative pressure ulcer prevention care bundle targeting patient participation in their care was recently tested in a cluster randomised trial in eight Australian hospitals. Understanding nurses' perspectives of such an intervention is imperative when interpreting results and translating evidence into practice. As part of a process evaluation for the main trial, this study assessed nurses' perceptions of the usefulness and impact of a pressure ulcer prevention care bundle intervention on clinical practice...
2016: BMC Nursing
https://www.readbyqxmd.com/read/27878426/the-differential-effects-of-alzheimer-s-disease-and-lewy-body-pathology-on-cognitive-performance-a-meta-analysis
#2
REVIEW
Ashita S Gurnani, Brandon E Gavett
Differential diagnosis of Alzheimer's disease (AD) from normal aging and other dementia etiologies is imperative for disease specific treatment options and long-term care planning. Neuropathological confirmation is the gold standard for neurodegenerative disease diagnosis, yet most published studies examining the use of neuropsychological tests in the differential diagnosis of dementia rely upon clinical diagnostic outcomes. The present study undertook a meta-analytic review of the literature to identify cognitive tests and domains that allow for the differentiation of individuals with AD pathology from individuals with dementia with Lewy Bodies (DLB) pathology and pathology-free individuals...
November 22, 2016: Neuropsychology Review
https://www.readbyqxmd.com/read/27876294/reprint-of-the-new-approach-to-epilepsy-classification-cognition-and-behavior-in-adult-epilepsy-syndromes
#3
REVIEW
Sallie Baxendale, Pamela Thompson
The revised terminology and concepts for the organization of seizures and epilepsy proposed by the ILAE Commission on Classification and Terminology in 2010 allows for a number of new opportunities in the study of cognition and behavior in adults. This review examines the literature that has looked for behavioral and cognitive correlates of the newly recognized genetic epilepsies in adults. While some studies report clear cognitive phenotypes associated with specific genetic mutations in adults with epilepsy, others report remarkable clinical heterogeneity...
November 18, 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27856411/personalising-exercise-recommendations-for-brain-health-considerations-and-future-directions
#4
Cindy K Barha, Liisa A Galea, Lindsay S Nagamatsu, Kirk I Erickson, Teresa Liu-Ambrose
The societal value of strategies that delay the onset and progression of dementia cannot be overstated. Physical activity-unstructured and structured-is a promising, cost-effective strategy for the promotion of brain health. However, a large degree of variation exists in its efficacy. Therefore, to increase its utility as 'medication' for healthy cognitive ageing, it is imperative to identify key moderators and mediators of the positive effects of targeted exercise training on brain health. In this commentary, we focus on the type of targeted exercise training, the determinants of individual variation, including biological sex and genotypic factors, and the mechanisms by which exercise exerts its influence on the brain...
November 17, 2016: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/27854227/do-psychosocial-interventions-improve-quality-of-life-and-wellbeing-in-adults-with-neuromuscular-disorders-a-systematic-review-and-narrative-synthesis
#5
Elaine Walklet, Kate Muse, Jane Meyrick, Tim Moss
Quality of life and well-being are frequently restricted in adults with neuromuscular disorders. As such, identification of appropriate interventions is imperative. The objective of this paper was to systematically review and critically appraise quantitative studies (RCTs, controlled trials and cohort studies) of psychosocial interventions designed to improve quality of life and well-being in adults with neuromuscular disorders. A systematic review of the published and unpublished literature was conducted. Studies meeting inclusion criteria were appraised using a validated quality assessment tool and results presented in a narrative synthesis...
August 30, 2016: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/27832767/chitinase-3-like-1-protein-chi3l1-locus-influences-cerebrospinal-fluid-levels-of-ykl-40
#6
Yuetiva Deming, Kathleen Black, David Carrell, Yefei Cai, Jorge L Del-Aguila, Maria Victoria Fernandez, John Budde, ShengMei Ma, Benjamin Saef, Bill Howells, Sarah Bertelsen, Kuan-Lin Huang, Courtney L Sutphen, Rawan Tarawneh, Anne M Fagan, David M Holtzman, John C Morris, Alison M Goate, Joseph D Dougherty, Carlos Cruchaga
BACKGROUND: Alzheimer's disease (AD) pathology appears several years before clinical symptoms, so identifying ways to detect individuals in the preclinical stage is imperative. The cerebrospinal fluid (CSF) Tau/Aβ42 ratio is currently the best known predictor of AD status and cognitive decline, and the ratio of CSF levels of chitinase-3-like 1 protein (CHI3L1, YKL-40) and amyloid beta (Aβ42) were reported as predictive, but individual variability and group overlap inhibits their utility for individual diagnosis making it necessary to find ways to improve sensitivity of these biomarkers...
November 10, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27810221/promoting-health-workers-ownership-of-infection-prevention-and-control-using-normalization-process-theory-as-an-interpretive-framework
#7
D J Gould, R Hale, E Waters, D Allen
BACKGROUND: All health workers should take responsibility for infection prevention and control (IPC). Recent reduction in key reported healthcare-associated infections in the UK is impressive, but the determinants of success are unknown. It is imperative to understand how IPC strategies operate as new challenges arise and threats of antimicrobial resistance increase. METHODS: The authors undertook a retrospective, independent evaluation of an action plan to enhance IPC and 'ownership' (individual accountability) for IPC introduced throughout a healthcare organization...
December 2016: Journal of Hospital Infection
https://www.readbyqxmd.com/read/27793659/do-anesthetics-harm-the-developing-human-brain-an-integrative-analysis-of-animal-and-human-studies
#8
Erica P Lin, Jeong-Rim Lee, Christopher S Lee, Meng Deng, Andreas W Loepke
Anesthetics permit surgical procedures and stressful interventions have been found to cause structural brain abnormalities and functional impairment in immature animals, generating extensive concerns among clinicians, parents, and government regulators regarding the safe use of these drugs in young children. Critically important questions remain, such as the exact age at which the developing brain is most vulnerable to the effects of anesthetic exposure, whether a particular age exists beyond which anesthetics are devoid of long-term effects on the brain, and whether any specific exposure duration exists that does not lead to deleterious effects...
October 26, 2016: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/27790138/splendor-in-the-grass-a-pilot-study-assessing-the-impact-of-medical-marijuana-on-executive-function
#9
Staci A Gruber, Kelly A Sagar, Mary K Dahlgren, Megan T Racine, Rosemary T Smith, Scott E Lukas
Currently, 25 states and Washington DC have enacted full medical marijuana (MMJ) programs while 18 states allow limited access to MMJ products. Limited access states permit low (or zero) tetrahydrocannabinol (THC) and high cannabidiol (CBD) products to treat specified conditions such as uncontrolled epilepsy. Although MMJ products are derived from the same plant species as recreational MJ, they are often selected for their unique cannabinoid constituents and ratios, not typically sought by recreational users, which may impact neurocognitive outcomes...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27776297/the-new-approach-to-epilepsy-classification-cognition-and-behavior-in-adult-epilepsy-syndromes
#10
REVIEW
Sallie Baxendale, Pamela Thompson
The revised terminology and concepts for the organization of seizures and epilepsy proposed by the ILAE Commission on Classification and Terminology in 2010 allows for a number of new opportunities in the study of cognition and behavior in adults. This review examines the literature that has looked for behavioral and cognitive correlates of the newly recognized genetic epilepsies in adults. While some studies report clear cognitive phenotypes associated with specific genetic mutations in adults with epilepsy, others report remarkable clinical heterogeneity...
November 2016: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/27752994/rodent-gymnastics-neurobehavioral-assays-in-ischemic-stroke
#11
Sreekala S Nampoothiri, Tanvi Potluri, Harshith Subramanian, Rajanikant G Krishnamurthy
Despite years of research, most preclinical trials on ischemic stroke have remained unsuccessful owing to poor methodological and statistical standards leading to "translational roadblocks." Various behavioral tests have been established to evaluate traits such as sensorimotor function, cognitive and social interactions, and anxiety-like and depression-like behavior. A test's validity is of cardinal importance as it influences the chance of a successful translation of preclinical results to clinical settings...
October 17, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27752305/dietary-patterns-are-associated-with-cognitive-function-in-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-cohort
#12
Keith E Pearson, Virginia G Wadley, Leslie A McClure, James M Shikany, Fred W Unverzagt, Suzanne E Judd
Identifying factors that contribute to the preservation of cognitive function is imperative to maintaining quality of life in advanced years. Of modifiable risk factors, diet quality has emerged as a promising candidate to make an impact on cognition. The objective of this study was to evaluate associations between empirically derived dietary patterns and cognitive function. This study included 18 080 black and white participants aged 45 years and older from the REasons for Geographic And Racial Differences in Stroke (REGARDS) cohort...
2016: Journal of Nutritional Science
https://www.readbyqxmd.com/read/27720820/the-norepinephrine-system-and-its-relevance-for-multi-component-behavior
#13
Moritz Mückschel, Krutika Gohil, Tjalf Ziemssen, Christian Beste
The ability to execute several actions in a specific temporal order to achieve an overarching goal, a process often termed action cascading or multi-component behavior, is essential for everyday life requirements. We are only at the beginning to understand the neurobiological mechanisms important for these cognitive processes. However, it is likely that the locus coeruleus-norepinephrine (LC-NE) system may be of importance. In the current study we examine the relevance of the LC-NE system for action cascading processes using a system neurophysiological approach combining high-density EEG recordings and source localization to analyze event-related potentials (ERPs) with recordings of pupil diameter as a proximate of LC-NE system activity...
October 5, 2016: NeuroImage
https://www.readbyqxmd.com/read/27719873/hypnosis-as-therapy-for-functional-neurologic-disorders
#14
Q Deeley
Suggestion in hypnosis has been applied to the treatment of functional neurologic symptoms since the earliest descriptions of hypnosis in the 19th century. Suggestion in this sense refers to an intentional communication of beliefs or ideas, whether verbally or nonverbally, to produce subjectively convincing changes in experience and behavior. The recognition of suggestion as a psychologic process with therapeutic applications was closely linked to the derivation of hypnosis from earlier healing practices. Animal magnetism, the immediate precursor of hypnosis, arrived at a psychologic concept of suggestion along with other ideas and practices which were then incorporated into hypnosis...
2017: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27687552/a-computer-human-interaction-model-to-improve-the-diagnostic-accuracy-and-clinical-decision-making-during-12-lead-electrocardiogram-interpretation
#15
Andrew W Cairns, Raymond R Bond, Dewar D Finlay, Cathal Breen, Daniel Guldenring, Robert Gaffney, Anthony G Gallagher, Aaron J Peace, Pat Henn
INTRODUCTION: The 12-lead Electrocardiogram (ECG) presents a plethora of information and demands extensive knowledge and a high cognitive workload to interpret. Whilst the ECG is an important clinical tool, it is frequently incorrectly interpreted. Even expert clinicians are known to impulsively provide a diagnosis based on their first impression and often miss co-abnormalities. Given it is widely reported that there is a lack of competency in ECG interpretation, it is imperative to optimise the interpretation process...
September 26, 2016: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/27663114/examining-internet-delivered-cognitive-behaviour-therapy-for-patients-with-chronic-kidney-disease-on-haemodialysis-a-feasibility-open-trial
#16
Ramony Chan, Blake F Dear, Nick Titov, Josephine Chow, Michael Suranyi
OBJECTIVE: Treating depression among patients with chronic kidney disease (CKD) is imperative because of its high prevalence and health-related costs. However, many patients with CKD experience significant barriers to effective face-to-face psychological treatments. Internet-delivered cognitive behaviour therapy (iCBT) may help overcome the treatment barriers. The aim of the present study was to explore the acceptability and preliminary efficacy of iCBT for depression and anxiety among patients with CKD on haemodialysis...
October 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27636743/improving-health-outcomes-for-patients-with-depression-a-population-health-imperative-report-on-an-expert-panel-meeting
#17
Janice L Clarke, Alexis Skoufalos, Alice Medalia, A Mark Fendrick
Improving Health Outcomes for Patients with Depression: A Population Health Imperative. Report on an Expert Panel Meeting Janice L. Clarke, RN, Alexis Skoufalos, EdD, Alice Medalia, PhD, and A. Mark Fendrick, MD Editorial: A Call to Action : David B. Nash, MD, MBA   S-2 OVERVIEW: Depression and the Population Health Imperative    S-3 Promoting Awareness of the Issues and Opportunities for Improvement    S-5 Cognitive Dysfunction in Affective Disorders    S-5 Critical Role of Employers in Improving Health Outcomes for Employees with Depression    S-6 Closing the Behavioral Health Professional and Process Gaps    S-6 Achieving the Triple Aim for Patients with Depressive Disorders    S-6 Improving the Experience of Care for Patients with Depression    S-6 Improving Quality of Care and Health Outcomes for Patients with Depression    S-7 Changing the Cost of Care Discussion from How Much to How Well    S-8 Panel Insights and Recommendations    S-9 Conclusion    S-10...
September 2016: Population Health Management
https://www.readbyqxmd.com/read/27598124/toxin-induced-experimental-models-of-learning-and-memory-impairment
#18
REVIEW
Sandeep Vasant More, Hemant Kumar, Duk-Yeon Cho, Yo-Sep Yun, Dong-Kug Choi
Animal models for learning and memory have significantly contributed to novel strategies for drug development and hence are an imperative part in the assessment of therapeutics. Learning and memory involve different stages including acquisition, consolidation, and retrieval and each stage can be characterized using specific toxin. Recent studies have postulated the molecular basis of these processes and have also demonstrated many signaling molecules that are involved in several stages of memory. Most insights into learning and memory impairment and to develop a novel compound stems from the investigations performed in experimental models, especially those produced by neurotoxins models...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27574308/repetition-suppression-a-means-to-index-neural-representations-using-bold
#19
REVIEW
Helen C Barron, Mona M Garvert, Timothy E J Behrens
Understanding how the human brain gives rise to complex cognitive processes remains one of the biggest challenges of contemporary neuroscience. While invasive recording in animal models can provide insight into neural processes that are conserved across species, our understanding of cognition more broadly relies upon investigation of the human brain itself. There is therefore an imperative to establish non-invasive tools that allow human brain activity to be measured at high spatial and temporal resolution...
October 5, 2016: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/27572865/pediatric-multiple-sclerosis-clinical-features-and-outcome
#20
Amy Waldman, Jayne Ness, Daniela Pohl, Isabella Laura Simone, Banu Anlar, Maria Pia Amato, Angelo Ghezzi
Multiple sclerosis (MS) in children manifests with a relapsing-remitting MS (RRMS) disease course. Acute relapses consist of new neurologic deficits persisting greater than 24 hours, in the absence of intercurrent illness, and occur with a higher frequency early in the disease as compared to adult-onset RRMS. Most pediatric patients with MS recover well from these early relapses, and cumulative physical disability is rare in the first 10 years of disease. Brainstem attacks, poor recovery from a single attack, and a higher frequency of attacks portend a greater likelihood of future disability...
August 30, 2016: Neurology
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