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https://www.readbyqxmd.com/read/28335550/preparation-of-biodegradable-and-elastic-poly-%C3%AE%C2%B5-caprolactone-co-lactide-copolymers-and-evaluation-as-a-localized-and-sustained-drug-delivery-carrier
#1
Ji Hoon Park, Bo Keun Lee, Seung Hun Park, Mal Geum Kim, Jin Woo Lee, Hye Yun Lee, Hai Bang Lee, Jae Ho Kim, Moon Suk Kim
To develop a biodegradable polymer possessing elasticity and flexibility, we synthesized MPEG-b-(PCL-co-PLA) copolymers (PCxLyA), which display specific rates of flexibility and elasticity. We synthesize the PCxLyA copolymers by ring-opening polymerization of ε-caprolactone and l-lactide. PCxLyA copolymers of various compositions were synthesized with 500,000 molecular weight. The PCxLyA copolymers mechanical properties were dependent on the mole ratio of the ε-caprolactone and l-lactide components. Cyclic tensile tests were carried out to investigate the resistance to creep of PCxLyA specimens after up to 20 deformation cycles to 50% elongation...
March 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335469/comparison-of-the-pharmacokinetic-properties-of-hemoglobin-based-oxygen-carriers
#2
REVIEW
Kazuaki Taguchi, Keishi Yamasaki, Toru Maruyama, Masaki Otagiri
Hemoglobin (Hb) is an ideal material for use in the development of an oxygen carrier in view of its innate biological properties. However, the vascular retention of free Hb is too short to permit a full therapeutic effect because Hb is rapidly cleared from the kidney via glomerular filtration or from the liver via the haptogloblin-CD 163 pathway when free Hb is administered in the blood circulation. Attempts have been made to develop alternate acellular and cellular types of Hb based oxygen carriers (HBOCs), in which Hb is processed via various routes in order to regulate its pharmacokinetic properties...
March 18, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28335376/genetic-polymorphisms-contribute-to-the-individual-variations-of-imatinib-mesylate-plasma-levels-and-adverse-reactions-in-chinese-gist-patients
#3
Jing Liu, Zhiyu Chen, Hanmei Chen, Yingyong Hou, Weiqi Lu, Junyi He, Hanxing Tong, Yuhong Zhou, Weimin Cai
Imatinib mesylate (IM) has dramatically improved the outcomes of gastrointestinal stromal tumor (GIST) patients. However, the clinical responses of IM may considerably vary among single individuals. This study aimed to investigate the influences of genetic polymorphisms of drug-metabolizing enzyme (CYP3A4), transporters (ABCB1, ABCG2), and nuclear receptor (Pregnane X Receptor (PXR, encoded by NR1I2)) on IM plasma levels and related adverse reactions in Chinese GIST patients. A total of 68 Chinese GIST patients who have received IM 300-600 mg/day were genotyped for six single nucleotide polymorphisms (SNPs) (CYP3A4 rs2242480; ABCB1 rs1045642; ABCG2 rs2231137; NRI12 rs3814055, rs6785049, rs2276706), and the steady-state IM trough plasma concentrations were measured by a validated HPLC method...
March 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28335362/the-change-of-electronic-transport-behaviors-by-p-and-b-doping-in-nano-crystalline-silicon-films-with-very-high-conductivities
#4
Dan Shan, Mingqing Qian, Yang Ji, Xiaofan Jiang, Jun Xu, Kunji Chen
Nano-crystalline Si films with high conductivities are highly desired in order to develop the new generation of nano-devices. Here, we first demonstrate that the grain boundaries played an important role in the carrier transport process in un-doped nano-crystalline Si films as revealed by the temperature-dependent Hall measurements. The potential barrier height can be well estimated from the experimental results, which is in good agreement with the proposed model. Then, by introducing P and B doping, it is found that the scattering of grain boundaries can be significantly suppressed and the Hall mobility is monotonously decreased with the temperature both in P- and B-doped nano-crystalline Si films, which can be attributed to the trapping of P and B dopants in the grain boundary regions to reduce the barriers...
December 3, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335355/influence-of-external-gaseous-environments-on-the-electrical-properties-of-zno-nanostructures-obtained-by-a-hydrothermal-method
#5
Marcin Procek, Tadeusz Pustelny, Agnieszka Stolarczyk
This paper deals with experimental investigations of ZnO nanostructures, consisting of a mixture of nanoparticles and nanowires, obtained by the chemical (hydrothermal) method. The influences of both oxidizing (NO₂) and reducing gases (H₂, NH₃), as well as relative humidity (RH) on the physical and chemical properties of ZnO nanostructures were tested. Carrier gas effect on the structure interaction with gases was also tested; experiments were conducted in air and nitrogen (N₂) atmospheres. The effect of investigated gases on the resistance of the ZnO nanostructures was tested over a wide range of concentrations at room temperature (RT) and at 200 °C...
November 29, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335343/photoelectrochemical-performance-observed-in-mn-doped-bifeo%C3%A2-heterostructured-thin-films
#6
Hao-Min Xu, Huanchun Wang, Ji Shi, Yuanhua Lin, Cewen Nan
Pure BiFeO₃ and heterostructured BiFeO₃/BiFe0.95Mn0.05O₃ (5% Mn-doped BiFeO₃) thin films have been prepared by a chemical deposition method. The band structures and photosensitive properties of these films have been investigated elaborately. Pure BiFeO₃ films showed stable and strong response to photo illumination (open circuit potential kept -0.18 V, short circuit photocurrent density was -0.023 mA·cm(-2)). By Mn doping, the energy band positions shifted, resulting in a smaller band gap of BiFe0...
November 16, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335335/contact-resistance-and-channel-conductance-of-graphene-field-effect-transistors-under-low-energy-electron-irradiation
#7
Filippo Giubileo, Antonio Di Bartolomeo, Nadia Martucciello, Francesco Romeo, Laura Iemmo, Paola Romano, Maurizio Passacantando
We studied the effects of low-energy electron beam irradiation up to 10 keV on graphene-based field effect transistors. We fabricated metallic bilayer electrodes to contact mono- and bi-layer graphene flakes on SiO₂, obtaining specific contact resistivity ρ c ≈ 19 k Ω · µ m 2 and carrier mobility as high as 4000 cm²·V(-1)·s(-1). By using a highly doped p-Si/SiO₂ substrate as the back gate, we analyzed the transport properties of the device and the dependence on the pressure and on the electron bombardment...
November 10, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335334/hybrid-nanostructures-containing-sulfadiazine-modified-chitosan-as-antimicrobial-drug-carriers
#8
Bogdanel Silvestru Munteanu, Raluca Petronela Dumitriu, Lenuta Profire, Liviu Sacarescu, Gabriela Elena Hitruc, Elena Stoleru, Marius Dobromir, Ana Lavinia Matricala, Cornelia Vasile
Chitosan (CH) nanofibrous structures containing sulfadiazine (SDZ) or sulfadiazine modified chitosan (SCH) in the form of functional nanoparticles attached to nanofibers (hybrid nanostructures) were obtained by mono-axial and coaxial electrospinning. The mono-axial design consisted of a SDZ/CH mixture solution fed through a single nozzle while the coaxial design consisted of SCH and CH solutions separately supplied to the inner and outer nozzle (or in reverse order). The CH ability to form nanofibers assured the formation of a nanofiber mesh, while SDZ and SCH, both in form of suspensions in the electrospun solution, assured the formation of active nanoparticles which remained attached to the CH nanofiber mesh after the electrospinning process...
November 10, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335319/influence-of-quantum-dot-concentration-on-carrier-transport-in-zno-tio%C3%A2-nano-hybrid-photoanodes-for-quantum-dot-sensitized-solar-cells
#9
Francis S Maloney, Uma Poudyal, Weimin Chen, Wenyong Wang
Zinc oxide nanowire and titanium dioxide nanoparticle (ZnO:TiO₂ NW/NP) hybrid films were utilized as the photoanode layer in quantum dot-sensitized solar cells (QDSSCs). CdSe quantum dots (QDs) with a ZnS passivation layer were deposited on the ZnO:TiO₂ NW/NP layer as a photosensitizer by successive ion layer adsorption and reaction (SILAR). Cells were fabricated using a solid-state polymer electrolyte and intensity-modulated photovoltage and photocurrent spectroscopy (IMVS/PS) was carried out to study the electron transport properties of the cell...
October 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335308/probe-microscopic-studies-of-dna-molecules-on-carbon-nanotubes
#10
REVIEW
Kazuo Umemura, Katsuki Izumi, Shusuke Oura
Hybrids of DNA and carbon nanotubes (CNTs) are promising nanobioconjugates for nanobiosensors, carriers for drug delivery, and other biological applications. In this review, nanoscopic characterization of DNA-CNT hybrids, in particular, characterization by scanning probe microscopy (SPM), is summarized. In many studies, topographical imaging by atomic force microscopy has been performed. However, some researchers have demonstrated advanced SPM operations in order to maximize its unique and valuable functions...
October 8, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335301/facile-synthesis-of-g-c%C3%A2-n%C3%A2-nanosheets-zno-nanocomposites-with-enhanced-photocatalytic-activity-in-reduction-of-aqueous-chromium-vi-under-visible-light
#11
Xiaoya Yuan, Chao Zhou, Qiuye Jing, Qi Tang, Yuanhua Mu, An-Ke Du
Graphitic-C₃N₄ nanosheets (CN)/ZnO photocatalysts (CN/ZnO) with different CN loadings were successfully prepared via a simple precipitation-calcination in the presence of exfoliated C₃N₄ nanosheets. Their morphology and structure were thoroughly characterized by powder X-ray diffraction (XRD), scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HRTEM), X-ray photoelectron spectroscopy (XPS), UV-Vis diffuse reflectance spectroscopy (DRS) and photoluminescence spectra (PL)...
September 14, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335293/cholesterol-modified-amino-pullulan-nanoparticles-as-a-drug-carrier-comparative-study-of-cholesterol-modified-carboxyethyl-pullulan-and-pullulan-nanoparticles
#12
Xiaojun Tao, Yongchao Xie, Qiufang Zhang, Ximin Qiu, Liming Yuan, Yi Wen, Min Li, Xiaoping Yang, Ting Tao, Minghui Xie, Yanwei Lv, Qinyi Wang, Xing Feng
To search for nano-drug preparations with high efficiency in tumor treatment, we evaluated the drug-loading capacity and cell-uptake toxicity of three kinds of nanoparticles (NPs). Pullulan was grafted with ethylenediamine and hydrophobic groups to form hydrophobic cholesterol-modified amino-pullulan (CHAP) conjugates. Fourier transform infrared spectroscopy and nuclear magnetic resonance were used to identify the CHAP structure and calculate the degree of substitution of the cholesterol group. We compared three types of NPs with close cholesterol hydrophobic properties: CHAP, cholesterol-modified pullulan (CHP), and cholesterol-modified carboxylethylpullulan (CHCP), with the degree of substitution of cholesterol of 2...
September 8, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335269/galactosylated-liposomes-for-targeted-co-delivery-of-doxorubicin-vimentin-sirna-to-hepatocellular-carcinoma
#13
Hea Ry Oh, Hyun-Young Jo, James S Park, Dong-Eun Kim, Je-Yoel Cho, Pyung-Hwan Kim, Keun-Sik Kim
The combination of therapeutic nucleic acids and chemotherapeutic drugs has shown great promise for cancer therapy. In this study, asialoglycoprotein receptors (ASGPR) targeting-ligand-based liposomes were tested to determine whether they can co-deliver vimentin siRNA and doxorubicin to hepatocellular carcinoma (HCC) selectively. To achieve this goal, we developed an ASGPR receptor targeted co-delivery system called gal-doxorubicin/vimentin siRNA liposome (Gal-DOX/siRNA-L). The Gal-DOX/siRNA-L was created via electrostatic interaction of galactose linked-cationic liposomal doxorubicin (Gal-DOX-L) on vimentin siRNA...
July 30, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335267/dna-based-enzyme-reactors-and-systems
#14
REVIEW
Veikko Linko, Sami Nummelin, Laura Aarnos, Kosti Tapio, J Jussi Toppari, Mauri A Kostiainen
During recent years, the possibility to create custom biocompatible nanoshapes using DNA as a building material has rapidly emerged. Further, these rationally designed DNA structures could be exploited in positioning pivotal molecules, such as enzymes, with nanometer-level precision. This feature could be used in the fabrication of artificial biochemical machinery that is able to mimic the complex reactions found in living cells. Currently, DNA-enzyme hybrids can be used to control (multi-enzyme) cascade reactions and to regulate the enzyme functions and the reaction pathways...
July 27, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335255/a-gallium-oxide-graphene-oxide-hybrid-composite-for-enhanced-photocatalytic-reaction
#15
Seungdu Kim, Kook In Han, In Gyu Lee, Won Kyu Park, Yeojoon Yoon, Chan Sei Yoo, Woo Seok Yang, Wan Sik Hwang
Hybrid composites (HCs) made up of gallium oxide (GaO) and graphene oxide (GO) were investigated with the intent of enhancing a photocatalytic reaction under ultraviolet (UV) radiation. The material properties of both GaO and GO were preserved, even after the formation of the HCs. The incorporation of the GO into the GaO significantly enhanced the photocatalytic reaction, as indicated by the amount of methylene blue (MB) degradation. The improvements in the reaction were discussed in terms of increased surface area and the retarded recombination of generated charged carriers...
July 1, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335247/hydrothermal-fabrication-of-silver-nanowires-silver-nanoparticles-graphene-nanosheets-composites-in-enhancing-electrical-conductive-performance-of-electrically-conductive-adhesives
#16
Hongru Ma, Jinfeng Zeng, Steven Harrington, Lei Ma, Mingze Ma, Xuhong Guo, Yanqing Ma
Silver nanowires-silver nanoparticles-graphene nanosheets (AgNWs-AgNPs-GN) hybrid nanomaterials were fabricated through a hydrothermal method by using glucose as a green reducing agent. The charge carriers of AgNWs-AgNPs-GN passed through defect regions in the GNs rapidly with the aid of the AgNW and AgNP building blocks, leading to high electrical conductivity of electrically conductive adhesives (ECA) filled with AgNWs-AgNPs-GN. The morphologies of synthesized AgNWs-AgNPs-GN hybrid nanomaterials were characterized by field emission scanning electron microscope (FESEM), and high resolution transmission electron microscopy (HRTEM)...
June 21, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335225/enhancing-the-photocurrent-of-top-cell-by-ellipsoidal-silver-nanoparticles-towards-current-matched-gainp-gainas-ge-triple-junction-solar-cells
#17
Yiming Bai, Lingling Yan, Jun Wang, Lin Su, Zhigang Yin, Nuofu Chen, Yuanyuan Liu
A way to increase the photocurrent of top-cell is crucial for current-matched and highly-efficient GaInP/GaInAs/Ge triple-junction solar cells. Herein, we demonstrate that ellipsoidal silver nanoparticles (Ag NPs) with better extinction performance and lower fabrication temperature can enhance the light harvest of GaInP/GaInAs/Ge solar cells compared with that of spherical Ag NPs. In this method, appropriate thermal treatment parameters for Ag NPs without inducing the dopant diffusion of the tunnel-junction plays a decisive role...
May 25, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28335197/cationic-nanoparticles-assembled-from-natural-based-steroid-lipid-for-improved-intracellular-transport-of-sirna-and-pdna
#18
Ruilong Sheng, Xiaoqing Zhuang, Zhao Wang, Amin Cao, Kaili Lin, Julian X X Zhu
Developing new functional biomaterials from biocompatible natural-based resources for gene/drug delivery has attracted increasing attention in recent years. In this work, we prepared a series of cationic nanoparticles (Diosarg-DOPE NPs) by assembly of a natural steroid diosgenin-based cationic lipid (Diosarg) with commercially-available helper lipid 1,2-dioleoyl-sn-glycero-3-phosphorethanolamine (DOPE). These cationic Diosarg-DOPE NPs were able to efficiently bind siRNA and plasmid DNA (pDNA) via electrostatic interactions to form stable, nano-sized cationic lipid nanoparticles instead of lamellar vesicles in aqueous solution...
April 13, 2016: Nanomaterials
https://www.readbyqxmd.com/read/28334919/antibiotics-trigger-initiation-of-sccmec-transfer-by-inducing-sos-responses
#19
Pilong Liu, Zhaowei Wu, Huping Xue, Xin Zhao
The rise of antimicrobial resistance limits therapeutic options for infections by methicillin-resistant staphylococci. The staphylococcal cassette chromosome mec (SCCmec) is a mobile genetic element as the only carrier of the methicillin-resistance determinants, the mecA or mecC gene. The use of antibiotics increases the spread of antibiotic resistance, but the mechanism by which antibiotics promote horizontal dissemination of SCCmec is largely unknown. In this study, we demonstrate that many antibiotics, including β-lactams, can induce the expression of ccrC1 and SCCmec excision from the bacterial chromosome...
March 3, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28334911/mertk-rs4374383-variant-predicts-incident-nonalcoholic-fatty-liver-disease-and-diabetes-role-of-mononuclear-cell-activation-and-adipokine-response-to-dietary-fat
#20
Giovanni Musso, Maurizio Cassader, Franco De Michieli, Elena Paschetta, Silvia Pinach, Francesca Saba, Daria Bongiovanni, Luciana Framarin, Mara Berrutti, Nicola Leone, Stefania Corvisieri, Renato Parente, Federica Molinaro, Antonio Sircana, Bo Simona, Roberto Gambino
The loss-of-function rs4374383 G>A variant in Myeloid-epithelial-reproductive Tyrosine Kinase (MERTK) gene has been linked to hepatic fibrosis in chronic liver diseases. MERTK is expressed by immune and non-immune cells involved in inflammation, metabolism and vascular homeostasis. We assessed the impact of MERTK rs4374383 G>A variant on nonalcoholic fatty liver disease (NAFLD) incidence and severity and on glucose and lipid metabolism.We followed-up 305 healthy nonobese nondiabetic, metabolic syndrome-free insulin sensitive participants in a population-based study, characterized for MERTK G>A polymorphism, adipokine profile and inflammatory markers...
March 8, 2017: Human Molecular Genetics
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