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https://www.readbyqxmd.com/read/29161657/effects-of-local-lipopolysaccharide-administration-on-the-expression-of-toll-like-receptor-4-and-pro-inflammatory-cytokines-in-uterus-and-oviduct-of-rabbit-does
#1
Laura Menchetti, Olimpia Barbato, Iulia Elena Filipescu, Giovanna Traina, Leonardo Leonardi, Angela Polisca, Alessandro Troisi, Gabriella Guelfi, Federica Piro, Gabriele Brecchia
Inflammation of the uterus and oviduct is associated with reduced reproductive performance in humans and domestic animals. Toll-like receptors are expressed in various immune and non-immune cells and play a crucial role in innate immunity. Toll-like receptor - 4 (TLR4) can detect lipopolysaccharide (LPS) from Gram-negative bacteria leading to the secretion of pro-inflammatory cytokines, chemokines, antimicrobial peptides and other inflammatory mediators. To investigate the effects of a local inflammation on the expression levels of TLR4 and pro-inflammatory cytokines, 12 female rabbits received an intracervical infusion with either saline solution endotoxin-free (carrier, 2 mL; n = 6) or LPS (500 μg diluted in 2 mL of saline solution; n = 6)...
November 5, 2017: Theriogenology
https://www.readbyqxmd.com/read/29161482/-abundance-composition-and-natural-infection-of-anopheles-mosquitoes-from-two-malaria-endemic-regions-of-colombia
#2
Carolina Montoya, Priscila Bascuñán, Julián Rodríguez-Zabala, Margarita M Correa
INTRODUCTION: In Colombia there are three Anopheles species implicated in malaria transmission as primary vectors; however, the local role of some Anopheles species must still be defined. OBJECTIVE: To determine the abundance, composition and natural infection rates for Anopheles mosquitoes with Plasmodium spp. in two malaria-endemic regions of Colombia. MATERIALS AND METHODS: Anopheles mosquitoes were collected using the human-landing catches and while resting in livestock corrals in nine localities of two malaria-endemic regions of Colombia...
March 29, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29161300/brca1-and-brca2-mutational-profile-and-prevalence-in-hereditary-breast-and-ovarian-cancer-hboc-probands-from-southern-brazil-are-international-testing-criteria-appropriate-for-this-specific-population
#3
Bárbara Alemar, Cleandra Gregório, Josef Herzog, Camila Matzenbacher Bittar, Cristina Brinckmann Oliveira Netto, Osvaldo Artigalas, Ida Vanessa D Schwartz, Jordy Coffa, Suzi Alves Camey, Jeffrey Weitzel, Patricia Ashton-Prolla
BACKGROUND: Germline pathogenic variants in BRCA1 and BRCA2 (BRCA) are the main cause of Hereditary Breast and Ovarian Cancer syndrome (HBOC). METHODS: In this study we evaluated the mutational profile and prevalence of BRCA pathogenic/likely pathogenic variants among probands fulfilling the NCCN HBOC testing criteria. We characterized the clinical profile of these individuals and explored the performance of international testing criteria. RESULTS: A pathogenic/likely pathogenic variant was detected in 19...
2017: PloS One
https://www.readbyqxmd.com/read/29161024/performance-and-stability-enhancement-of-in-sn-zn-o-tfts-using-sio2-gate-dielectrics-grown-by-low-temperature-atomic-layer-deposition
#4
Jiazhen Sheng, Ju-Hwan Han, Wan-Ho Choi, Jozeph Park, Jin-Seong Park
Silicon dioxide (SiO2) films were synthesized by plasma enhanced atomic layer deposition (PEALD) using BTBAS (bis(tertiarybutylamino) silane) as the precursor and O2 plasma as the reactant, at a temperature range of 50 to 200 °C. While dielectric constant values larger than 3.7 are obtained at all deposition temperatures, the leakage current levels are drastically reduced to below 10-12 A at temperatures above 150 °C, which are similar to those obtained in thermally oxidized and PECVD grown SiO2. Thin film transistors (TFTs) based on In-Sn-Zn-O (ITZO) semiconductors were fabricated using thermal SiO2, PECVD SiO2 and PEALD SiO2 grown at 150 °C as the gate dielectrics, and superior device performance and stability are observed in the last case...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29161022/structural-and-functional-studies-of-the-daunorubicin-priming-ketosynthase-dpsc
#5
David R Jackson, Gaurav Shakya, Avinash B Patel, Lina Y Mohammed, Kostas Vasilakis, Pakorn Wattana-Amorn, Timothy R Valentic, Jacob Milligan, Matthew P Crump, John Crosby, Shiou-Chuan Tsai
Daunorubicin is a type II polyketide, one of a large class of polyaromatic natural products with anticancer, antibiotic and antiviral activity. Type II polyketides are formed by the assembly of malonyl-CoA building blocks, though in rare cases, biosynthesis is initiated by the incorporation of a non-malonyl derived starter unit, which adds molecular diversity to the poly-β-ketone backbone. Priming mechanisms for the transfer of novel starter units onto polyketide synthases (PKS) are still poorly understood...
November 21, 2017: ACS Chemical Biology
https://www.readbyqxmd.com/read/29160906/100-fold-enhancement-of-carrier-transport-in-uniaxial-oriented-mesoporous-anatase-tio2-films
#6
Xinjian Feng, Ke Li, Xia Sheng, Liping Chen, Tao Xu, Kai Zhu, Jie Liu
Mesoporous semiconductor films are of considerable interest for applications in photoelectrochemical devices, however, despite intensive research till now, their charge transport properties remain significantly lower than their single-crystal counterparts. Herein, we report a novel low-temperature template-free technique for growing high surface area mesoporous anatase TiO2 films with a preferred [001] crystalline-orientation on FTO-coated glass substrate. Compared to mesoporous films that comprised of randomly oriented crystallites, the uniaxial orientation enables a 100-fold increase in the rate of electron transport...
November 21, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29160846/a-triphenylphosphonium-functionalized-mitochondriotropic-nanocarrier-for-efficient-co-delivery-of-doxorubicin-and-chloroquine-and-enhanced-antineoplastic-activity
#7
Katerina N Panagiotaki, Zili Sideratou, Spiros A Vlahopoulos, Maria Paravatou-Petsotas, Michael Zachariadis, Nikolas Khoury, Vassilis Zoumpourlis, Dimitris Tsiourvas
Drug delivery systems that target subcellular organelles and, in particular, mitochondria are considered to have great potential in treating disorders that are associated with mitochondrial dysfunction, including cancer or neurodegenerative diseases. To this end, a novel hyperbranched mitochondriotropic nanocarrier was developed for the efficient co-delivery of two different (both in chemical and pharmacological terms) bioactive compounds. The carrier is based on hyperbranched poly(ethyleneimine) functionalized with triphenylphosphonium groups that forms ~100 nm diameter nanoparticles in aqueous media and can encapsulate doxorubicin (DOX), a well-known anti-cancer drug, and chloroquine (CQ), a known chemosensitizer with arising potential in anticancer medication...
November 21, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29160844/altered-aconitase-2-activity-in-huntington-s-disease-peripheral-blood-cells-and-mouse-model-striatum
#8
Chiung-Mei Chen, Yih-Ru Wu, Kuo-Hsuan Chang
Huntington's disease (HD) is caused by an unstable cytosine adenine guanine (CAG) trinucleotide repeat expansion encoding a polyglutamine tract in the huntingtin protein. Previously, we identified several up- and down-regulated protein molecules in the striatum of the Hdh((CAG)150) knock-in mice at 16 months of age, a mouse model which is modeling the early human HD stage. Among those molecules, aconitase 2 (Aco2) located in the mitochondrial matrix is involved in the energy generation and susceptible to increased oxidative stress that would lead to inactivation of Aco2 activity...
November 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29160835/vitamin-d-and-neurological-diseases-an-endocrine-view
#9
REVIEW
Carolina Di Somma, Elisabetta Scarano, Luigi Barrea, Volha V Zhukouskaya, Silvia Savastano, Chiara Mele, Massimo Scacchi, Gianluca Aimaretti, Annamaria Colao, Paolo Marzullo
Vitamin D system comprises hormone precursors, active metabolites, carriers, enzymes, and receptors involved in genomic and non-genomic effects. In addition to classical bone-related effects, this system has also been shown to activate multiple molecular mediators and elicit many physiological functions. In vitro and in vivo studies have, in fact, increasingly focused on the "non-calcemic" actions of vitamin D, which are associated with the maintenance of glucose homeostasis, cardiovascular morbidity, autoimmunity, inflammation, and cancer...
November 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29160732/optimization-and-characterization-of-sertaconazole-nitrate-flexisomes-embedded-in-hydrogel-for-improved-antifungal-activity
#10
Satish K Mandlik, Shridhar S Siras, Kiran R Birajdar
The aim of the present research work was to develop, characterize and optimize sertaconazole nitrate (STZN) embedded flexisomes (STZN-FS) to improve the cutaneous anti-fungal activity of STZN. Flexisomes are self-aggregating, flexible, deformable lipidic vesicles possessing an aqueous core. A 3(2) factorial design was implemented to optimize the effects of the critical material attributes of concentration of phospholipid (X1) and edge activator (X2) on the critical quality attributes of particle size (Y1), entrapment efficiency (Y2) and deformability index (Y3)...
November 21, 2017: Journal of Liposome Research
https://www.readbyqxmd.com/read/29160715/deciphering-charging-status-absolute-quantum-efficiency-and-absorption-cross-section-of-multi-carrier-states-in-single-colloidal-quantum-dot
#11
Weiwang Xu, Xiaoqi Hou, Yongjun Meng, Renyang Meng, Zhiyuan Wang, Haiyan Qin, Xiaogang Peng, Xue-Wen Chen
Upon photo- or electrical-excitation, colloidal quantum dots (QDs) are often found in multi-carrier states due to multi-photon absorption and photo-charging of the QDs. While many of these multi-carrier states are observed in single-dot spectroscopy, their properties are not well studied due to random charging/discharging, emission intensity intermittency, and uncontrolled surface defects of single QD. Here we report in-situ deciphering the charging status, and precisely assessing the absorption cross section, and determining the absolute emission quantum yield of mono-exciton and biexciton states for neutral, positively-charged, and negatively-charged single core/shell CdSe/CdS QD...
November 21, 2017: Nano Letters
https://www.readbyqxmd.com/read/29160706/synthesis-and-characterization-of-ultralow-fouling-poly-n-acryloyl-glycinamide-brushes
#12
Fengyu Yang, Yonglan Liu, Yanxian Zhang, Baiping Ren, Jianxiong Xu, Jie Zheng
Rational design of biomaterials with antifouling properties still remains a challenge, but is important for many bench-to-bedside applications for biomedical implants, drug delivery carriers, and marine coatings. Herein we synthesized and characterized poly(N-acryloylglycinamide) (polyNAGA) and then grafted poly(NAGA) onto Au substrate to form polymer brushes with well controlled film stability, wettability and thickness using the surface-initiated atom transfer radical polymerization (SI-ATRP). The NAGA monomer integrates two hydrophilic amides on the side chain to enhance surface hydration, which is thought as a critical contributor to antifouling property...
November 21, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/29160703/ruthenium-carbon-rich-group-as-a-redox-switchable-metal-coupling-unit-in-linear-trinuclear-complexes
#13
Emmanuel Di Piazza, Corentin Boilleau, Antoine Vacher, Khalissa Merahi, Lucie Norel, Karine Costuas, Thierry Roisnel, Sylvie Choua, Philippe Turek, Stéphane Rigaut
The preparation and properties of novel ruthenium carbon-rich complexes [(Ph-C≡C-)2-nRu(dppe)2(-C≡C-bipyM(hfac)2)n] (n = 1, 2; M = Cu(II), Mn(II); bipy = 2,2'-bipyridin-5-yl) characterized by single-crystal X-ray diffraction and designed for molecular magnetism are reported. With the help of EPR spectroscopy, we show that the neutral ruthenium system sets up a magnetic coupling between two remote paramagnetic Cu(II) units. More specifically, these copper compounds are unique examples of bimetallic and linear heterotrimetallic compounds for which a complete rationalization of the magnetic interactions could be made for exceptionally long distances between the spin carriers (8...
November 21, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29160685/graphene-oxide-a-new-carrier-for-slow-release-of-plant-micronutrients
#14
Shervin Kabiri, Fien Degryse, Diana N H Tran, Rodrigo da Silva, Michael J McLaughlin, Dusan Losic
The environmental problems and low efficiency associated with conventional fertilizers provides an impetus to develop advanced fertilizers with slower release and better performances. Here we report of development of a new carrier platform based on graphene oxide (GO) sheets that can provide a high loading of plant micronutrients with controllable slow release. To prove this concept two micronutrients zinc (Zn) and copper (Cu) were used to load on GO sheets and hence formulate GO-based micronutrients fertilizer...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160684/improving-the-stability-of-high-performance-multilayer-mos2-field-effect-transistors
#15
Na Liu, Jongyeol Baek, Seung Min Kim, Seongin Hong, Young Ki Hong, Yang Soo Kim, Hyun-Suk Kim, Sunkook Kim, Jozeph Park
In this study, we propose a method for improving the stability of multilayer MoS2 field-effect transistors (FETs) by O2 plasma treatment and Al2O3 passivation sustaining high-performance characteristics of bulk MoS2 FET. The MoS2 FETs were exposed to O2 plasma for 30 s prior to Al2O3 encapsulation, showing a relatively small hysteresis and a high electrical performance. The MoOx layer formed during the plasma treatment was found between MoS2 and the top passivation layer. This MoOx interlayer prevents the generation of excess electron carriers in the channel due to Al2O3 passivation, minimizing the shift of threshold voltage (Vth) and increase of off-current leakage...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29160506/treatment-adherence-in-patients-living-with-hiv-aids-assisted-at-a-specialized-facility-in-brazil
#16
Simone Miyada, Artênio José Ísper Garbin, Renata Colturato Joaquim Gatto, Cléa Adas Saliba Garbin
INTRODUCTION: In the 1990s, Brazil adopted a public policy that allowed for universal, free access to antiretroviral therapy (ART). Since then, treatment adherence has become a new challenge for administrators of sexually transmitted disease/acquired immunodeficiency syndrome (STD/AIDS) policies. This study quantified adherence to ART and verified whether there is an association between sociodemographic variables and clinical/laboratory data in human immunodeficiency virus (HIV)-infected patients...
September 2017: Revista da Sociedade Brasileira de Medicina Tropical
https://www.readbyqxmd.com/read/29160244/pulmonary-aspiration-in-adjustable-gastric-banding-carriers-undergoing-a-second-surgical-procedure-considerations-on-personal-experience-and-review-of-the-literature
#17
Contardo Vergani, Marco Venturi, Sara Badiali, Barbara Chella, Enrico Mozzi
BACKGROUND: The observation of a relatively high number of pulmonary aspirations (PA) among gastric band (GB) carriers undergoing a second surgery, prompted us to modify our strategy for GB patients candidate to further operation under general anesthesia. MATERIAL OF STUDY AND RESULTS: In January 2013, following the occurrence of PA at the induction of general anesthesia in 1 GB carrier undergoing a further operation, we reviewed our Data Base between January 2005 and 2013, to explore the rate of pulmonary aspiration in patients GB carriers undergoing a second surgery...
November 7, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29160235/possibile-half-metallicity-and-variable-range-hopping-transport-in-sb-substituted-fe-sub-2-sub-tisn-heusler-alloys
#18
Sayan Chaudhuri, P A Bhobe, Arun Kumar Nigam
Investigation of magnetotransport properties on Fe<sub>2</sub>TiSn<sub>1-x</sub>Sb<sub>x</sub> with 0 ≤ x ≤ 0.6 are presented in this paper. The substitution of Sb in place of Sn decreases the antisite disorder as evident from X ray diffraction patterns as well as from transport properties measurement. The much-disputed upturn in low temperature electrical resistivity of Fe<sub>2</sub>TiSn has been demonstrated to be a result of weak localization induced by antisite disorder...
November 21, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29160121/near-infrared-light-responsive-nanoparticles-for-improved-anticancer-efficacy-through-synergistic-chemo-photothermal-therapy
#19
Yanli Li, Bing Xin Xiao, Jie Dong, Yun Liu, Shan Gao, Jie Pang, Zengxian Sun
Combined treatment is more effective than single treatment against most forms of cancer. The synergistic chemo-thermotherapy mediated by nanoparticles has superior advantages of lesser adverse effects as a promising cancer therapy modality. In this study, we report a theranostic carrier system co-encapsulating Doxorubicin (DOX) and Indocyanine green (ICG) into the D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS). Full physicochemical characterization studies of the DOX/ICG-loaded TPGS nanoparticles (TNPs) are performed...
November 21, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/29160075/electron-and-hole-g-factors-and-spin-dynamics-of-negatively-charged-excitons-in-cdse-cds-colloidal-nanoplatelets-with-thick-shells
#20
Elena V Shornikova, Louis Biadala, Dmitri R Yakovlev, Donghai Feng, Victor F Sapega, Nathan Flipo, Aleksandr A Golovatenko, Marina A Semina, Anna V Rodina, Anatolie Mitioglu, Mariana V Ballottin, Peter C M Christianen, Yuri G Kusrayev, Michel Nasilowski, Benoit Dubertret, Manfred Bayer
We address spin properties and spin dynamics of carriers and charged excitons in CdSe/CdS colloidal nanoplatelets with thick shells. Magneto-optical studies are performed by time-resolved and polarization-resolved photoluminescence, spin-flip Raman scattering and picosecond pump-probe Faraday rotation in magnetic fields up to 30 T. We show that at low temperatures the nanoplatelets are negatively charged so that their photoluminescence is dominated by radiative recombination of negatively charged excitons (trions)...
November 21, 2017: Nano Letters
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