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https://www.readbyqxmd.com/read/28728378/phenotypic-diversity-major-genes-and-production-potential-of-local-chickens-and-guinea-fowl-in-tamale-northern-ghana
#1
Michael Mensah Brown, Benjamin Alenyorege, Gabriel Ayum Teye, Regina Roessler
Objective: Our study provides information on phenotypes of local chickens and guinea fowl and their body measures as well as on major genes in local chickens in northern Ghana. Methods: Qualitative and morphometric traits were recorded on 788 local chickens and 394 guinea fowl in urban households in Tamale, Ghana. Results: The results showed considerable variation of color traits and numerous major genes in local chickens, while color variations and related genotypes in guinea fowl were limited...
June 26, 2017: Asian-Australasian Journal of Animal Sciences
https://www.readbyqxmd.com/read/28728147/efficient-maximum-likelihood-estimation-for-pedigree-data-with-the-sum-product-algorithm
#2
Alexander Engelhardt, Anna Rieger, Achim Tresch, Ulrich Mansmann
OBJECTIVE: We analyze data sets consisting of pedigrees with age at onset of colorectal cancer (CRC) as phenotype. The occurrence of familial clusters of CRC suggests the existence of a latent, inheritable risk factor. We aimed to compute the probability of a family possessing this risk factor as well as the hazard rate increase for these risk factor carriers. Due to the inheritability of this risk factor, the estimation necessitates a costly marginalization of the likelihood. METHODS: We propose an improved EM algorithm by applying factor graphs and the sum-product algorithm in the E-step...
July 21, 2017: Human Heredity
https://www.readbyqxmd.com/read/28728086/nanostructured-lipid-systems-modified-with-waste-material-of-propolis-for-wound-healing-design-in-vitro-and-in-vivo-evaluation
#3
Hélen Cássia Rosseto, Lucas de Alcântara Sica de Toledo, Lizziane Maria Belloto de Francisco, Elisabetta Esposito, Yunsook Lim, Giuseppe Valacchi, Rita Cortesi, Marcos Luciano Bruschi
Propolis, a natural compound that can accelerate the wound healing process, is mainly used as ethanolic extract. The extractive solution may also be obtained from the propolis by-product (BP), transforming this waste material into a pharmaceutical active ingredient. Even if propolis does not show toxicity, when used as an extract over harmed skin or mucosa, the present ethanol content may be harmful to the tissue recovering, besides hindering the drug release. This study describes the development of solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) as topical propolis delivery systems and the investigation of their in vitro and in vivo activities...
July 10, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28728028/direct-evidence-of-the-photocatalytic-generation-of-reactive-oxygen-species-ros-in-a-bi2w2o9-layered-structure
#4
S Obregón, M A Ruíz-Gómez, D B Hernández-Uresti
In the present work, the Bi2W2O9 photocatalyst has been prepared by an easy and prompt co-precipitation route. From the structural characterization, we have stated that the formation of the Bi2W2O9 is accompanied by a small amount of the Bi2WO6 oxide, which gradually decreases by increasing the calcination temperature. The conduction and valence band edges of the Bi2W2O9 semiconductor were experimentally estimated for the first time using the X-ray photoelectron (XPS) and diffuse reflectance (DRS) spectroscopies...
July 8, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28727855/association-of-apoe-gene-polymorphism-with-lipid-profile-and-coronary-artery-disease-in-afro-caribbeans
#5
Laurent Larifla, Christophe Armand, Jacqueline Bangou, Anne Blanchet-Deverly, Patrick Numeric, Christiane Fonteau, Carl-Thony Michel, Séverine Ferdinand, Véronique Bourrhis, Fritz-Line Vélayoudom-Céphise
OBJECTIVES: Apolipoprotein E gene (APOE) polymorphism is associated with the lipid profile and cardio-vascular disease. However, these relationships vary between ethnic groups. We evaluated, for the first time in an Afro-Caribbean population, the distribution of APOE polymorphisms and their associations with coronary artery disease (CAD), the lipid profile and other cardio-metabolic risk factors. METHODS: We studied 712 Afro-Caribbean subjects including 220 with documented CAD and 492 healthy subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28727849/associations-between-pparg-polymorphisms-and-the-risk-of-essential-hypertension
#6
Gaojun Cai, Xinyong Zhang, Weijin Weng, Ganwei Shi, Sheliang Xue, Bifeng Zhang
BACKGROUND: Peroxisome proliferator-activated receptor gamma (PPARG) plays an important role in the pathogenesis and maintenance of essential hypertension (EH). It has been suggested that polymorphisms of PPARG are associated with the risk of EH. However, findings to date remain controversial. To elucidate the associations between the PPARG Pro12Ala and C161T polymorphisms and EH risk, a meta-analysis was carried out. METHODS: A comprehensive literature search of PubMed, Embase, CNKI (Chinese National Knowledge Infrastructure), VIP and Wanfang databases was conducted...
2017: PloS One
https://www.readbyqxmd.com/read/28727843/atomistic-modeling-of-alternating-access-of-a-mitochondrial-adp-atp-membrane-transporter-with-molecular-simulations
#7
Koichi Tamura, Shigehiko Hayashi
The mitochondrial ADP/ATP carrier (AAC) is a membrane transporter that exchanges a cytosolic ADP for a matrix ATP. Atomic structures in an outward-facing (OF) form which binds an ADP from the intermembrane space have been solved by X-ray crystallography, and revealed their unique pseudo three-fold symmetry fold which is qualitatively different from pseudo two-fold symmetry of most transporters of which atomic structures have been solved. However, any atomic-level information on an inward-facing (IF) form, which binds an ATP from the matrix side and is fixed by binding of an inhibitor, bongkrekic acid (BA), is not available, and thus its alternating access mechanism for the transport process is unknown...
2017: PloS One
https://www.readbyqxmd.com/read/28727815/polymorphisms-associated-with-everolimus-pharmacokinetics-toxicity-and-survival-in-metastatic-breast-cancer
#8
Tomas Pascual, María Apellániz-Ruiz, Cristina Pernaut, Cecilia Cueto-Felgueroso, Pablo Villalba, Carlos Álvarez, Luis Manso, Lucia Inglada-Pérez, Mercedes Robledo, Cristina Rodríguez-Antona, Eva Ciruelos
PURPOSE: Metastatic breast cancer (MBC) progressing after endocrine therapy frequently activates PI3K/AKT/mTOR pathway. The BOLERO-2 trial showed that everolimus-exemestane achieves increased progression free survival (PFS) compared with exemestane. However, there is great inter-patient variability in toxicity and response to exemestane-everolimus treatment. The objective of this study was to perform an exploratory study analyzing the implication of single nucleotide polymorphisms (SNPs) on outcomes from this treatment through a pharmacogenetic analysis...
2017: PloS One
https://www.readbyqxmd.com/read/28727732/incidence-of-thromboembolic-events-in-asymptomatic-carriers-of-iga-anti-%C3%A3-2-glycoprotein-i-antibodies
#9
Carlos Tortosa, Oscar Cabrera-Marante, Manuel Serrano, José A Martínez-Flores, Dolores Pérez, David Lora, Luis Morillas, Estela Paz-Artal, José M Morales, Daniel Pleguezuelo, Antonio Serrano
BACKGROUND: The antiphospholipid syndrome (APS) is defined by simultaneous presence of vascular clinical events and antiphospholipid antibodies (aPL). The aPL considered as diagnostics are lupus anticoagulant and antibodies anticardiolipin (aCL) and anti-ß2 glycoprotein-I (aB2GP1). During recent years, IgA aB2GP1 antibodies have been associated with thrombotic events both in patients positive, and mainly negative for other aPL, however its value as a pro-thrombotic risk-factor in asymptomatic patients has not been well defined...
2017: PloS One
https://www.readbyqxmd.com/read/28727460/2d-organic-superlattice-promoted-via-combined-action-of-%C3%AF-%C3%AF-stacking-and-dipole-dipole-interaction-in-discotic-liquid-crystals
#10
Wanying Zhang, Shuai-Feng Zhang, Zhenhu Zhang, Huanzhi Yang, Ao Zhang, Xingtian Hao, Jianchuang Wang, Chunxiu Zhang, Jialing Pu
A series of discotic liquid crystals based on hexapentyloxytriphenylene (HAT5) have been investigated where one out of the six ether side chains of a triphenylene core was replaced by an ester side chain and named for 5a-5h. During the process of studying these compounds, the characteristic straight line defect of ordered columnar structure was identified by polarizing optical microscopy (POM) and liquid crystal state over a wide temperature range was obtained by differential scanning calorimetry (DSC). Basic phase structure and molecular arrangement were assigned by one-dimensional wide-angle X-ray diffraction (1D WAXD), small angle X-ray scattering (SAXS), two-dimensional wide-angle X-ray diffraction (2D WAXD) and transmission electron microscope (TEM)...
July 20, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28727458/unraveling-the-high-voc-and-high-performance-of-integrated-perovskite-organic-bulk-heterojunction-solar-cells
#11
Shiqi Dong, Yongsheng Liu, Ziruo Hong, En-Ping Yao, Pengyu Sun, Lei Meng, Yuze Lin, Jinsong Huang, Gang Li, Yang Yang
We have demonstrated high performance integrated perovskite/bulk-heterojunction (BHJ) solar cells due to the low carrier recombination velocity, high open circuit voltage (Voc) and increased light absorption ability in near-infrared (NIR) region of integrated devices. In particular, we find that the Voc of the integrated devices is dominated by (or pinned to) the perovskite cells, not the OPV cells. A Quasi-Fermi Level Pinning Model was proposed to understand the working mechanism and the origin of the Voc of the integrated perovskite/BHJ solar cell, which following that of the perovskite solar cell and is much higher than that of the low bandgap polymer based organic BHJ solar cell...
July 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/28727321/micelle-directing-synthesis-of-the-ag-doped-wo3-and-moo3-composite-for-the-photocatalytic-water-oxidation-and-organic-dyes-adsorption
#12
Nasen Bate, Hongfei Shi, Li Chen, Jiabo Wang, Shasha Xu, Weilin Chen, Jianping Li, En-Bo Wang
In this paper, Ag-doped WO3 (MoO3) composite has been prepared by a simple micelle directed method and high temperature sintering route. The as-prepared samples were characterized by XRD, ICP, TEM, XPS, DRS, BET, PL and EIS techniques. The photocatalytic experiments reveal that their oxygen production rates are up to 95.43 μmol (75.45 μmol) for Ag-doped WO3 (MoO3), which is 9.5 (7.3) times higher than that of pure WO3: 9.012 μmol (MoO3: 9.00 μmol) under visible light illumination (λ ≥ 420 nm), respectively...
July 20, 2017: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/28727246/recognition-and-extraction-of-cesium-hydroxide-and-carbonate-using-a-neutral-multitopic-ion-pair-receptor
#13
Qing He, Gretchen Marie Peters, Vincent M Lynch, Jonathan L Sessler
Current approaches to lowering the pH of basic media rely on the addition of a proton source. An alternative approach is described here that involves the liquid-liquid extraction-based removal of cesium salts, specifically CsOH and Cs2CO3, from highly basic media. A multitopic ion-pair receptor (2) is used that can recognize and extract the hydroxide and carbonate anions as their cesium salts, as confirmed by 1H NMR spectroscopic titrations, ICP-MS, single-crystal structural analyses and theoretical calculations...
July 20, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28727178/tailored-band-gaps-in-sulphur-and-nitrogen-containing-porous-donor-acceptor-polymers-snps
#14
Dana Schwarz, Yaroslav S Kochergin, Amitava Acharja, Arun Ichangi, Maksym V Opanasenko, Jiří Čejka, Uwe Lappan, Pal Arki, Junjie He, Johannes Schmidt, Petr Nachtigall, Arne Thomas, Michael Janus Bojdys
Donor-acceptor dyads hold the key to tuning of electrochemical properties and enhanced mobility of charge carriers, yet their incorporation into a heterogeneous polymer network proves difficulty due to the fundamentally different chemistry of the donor- and acceptor-subunits. We present a family of sulphur and nitrogen containing porous polymers (SNPs) that are obtained via Sonogashira-Hagihara cross-coupling and that combine electron-withdrawing triazine (C3N3) and electron donating, sulphur-containing linkers...
July 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28727142/genomic-and-transcriptomic-heterogeneity-of-colorectal-tumors-arising-in-lynch-syndrome
#15
Hans Binder, Lydia Hopp, Michal R Schweiger, Steve Hoffmann, Frank Jühling, Martin Kerick, Bernd Timmermann, Susann Siebert, Christina Grimm, Lilit Nersisyan, Arsen Arakelyan, Maria Herberg, Peter Buske, Henry Loeffler-Wirth, Maciej Rosolowski, Christoph Engel, Jens Przybilla, Martin Peifer, Nicolaus Friedrichs, Gabriela Moeslein, Margarete Odenthal, Michelle Hussong, Sophia Peters, Stefanie Holzapfel, Jacob Nattermann, Robert Hueneburg, Wolff Schmiegel, Brigitte Royer-Pokora, Stefan Aretz, Michael Kloth, Matthias Kloor, Reinhard Buettner, Jörg Galle, Markus Loeffler
Colorectal cancer (CRC) arising in Lynch Syndrome (LS) comprises tumors with constitutional mutations in DNA mismatch-repair genes. Whole-genome and transcriptome studies of LS-CRC are still missing to address questions about similarities and differences of mutation and gene expression characteristics between LS-CRC and sporadic CRC, about the molecular heterogeneity of LS-CRC and about specific mechanisms of LS-CRC genesis linked to dysfunctional mismatch-repair in LS colonic mucosa and the possible role of immune editing...
July 20, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28727140/respiratory-sinus-arrhythmia-in-the-fourth-decade-of-life-depends-on-birth-weight-and-the-drd4-gene-implications-for-understanding-the-development-of-emotion-regulation
#16
Calan Savoy, Karen J Mathewson, Louis A Schmidt, Katherine M Morrison, John E Krzeczkowski, Ryan J Van Lieshout
INTRODUCTION: The long allele of the DRD4 gene can confer different behavioral and emotional phenotypes depending upon environmental exposure, although the physiological changes underlying these phenotypes are not fully known. We sought to extend this work by assessing the interaction of the DRD4 gene and exposure to perinatal adversity (indexed by extremely low birth weight [ELBW]) on resting respiratory sinus arrhythmia (RSA), a neurophysiological measure of emotion regulation, in adulthood...
July 20, 2017: Developmental Psychobiology
https://www.readbyqxmd.com/read/28727112/effect-of-in-ovo-feeding-of-l-arginine-on-the-hatchability-growth-performance-gastrointestinal-hormones-and-jejunal-digestive-and-absorptive-capacity-of-posthatch-broilers
#17
T Gao, M Zhao, L Zhang, J Li, L Yu, P Lv, F Gao, G Zhou
This study was conducted to investigate the effects of in ovo feeding (IOF) of Arg solution on the hatchability, growth performance, gastrointestinal hormones, serum AA, activities of digestive enzymes, and mRNA expressions of sensing receptors and nutrient transporters in the jejunum of posthatch broilers. One thousand two hundred embryonated eggs with similar weight were randomly allocated to 5 groups consisting of 8 replicates of 40 eggs each. The 5 treatments were arranged as a noninjected control, a diluent-injected (0...
July 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28726952/porphyra-polysaccharide-derived-carbon-dots-for-non-viral-co-delivery-of-different-gene-combinations-and-neuronal-differentiation-of-ectodermal-mesenchymal-stem-cells
#18
Jiaxin Chen, Qiang Wang, Jie Zhou, Wenwen Deng, Qingtong Yu, Xia Cao, Jianping Wang, Fengxia Shao, Yang Li, Ping Ma, Myron Spector, Jiangnan Yu, Ximing Xu
In this study, multifunctional fluorescent carbon dots (CDs) were synthesized using a one-pot hydrothermal carbonization reaction, with the naturally-occurring porphyra polysaccharide (PPS) serving as a single carbon source for the first time and ethylenediamine (Ed) acting as the surface passivation agent. The resulting CDs enjoyed a high quantum yield (56.3%), excitation-dependent fluorescence, small size (<10 nm), spherical shape, uniform distribution, positive surface charge, low cytotoxicity and excellent ability to condense macromolecular plasmid DNA...
July 20, 2017: Nanoscale
https://www.readbyqxmd.com/read/28726909/lysine-based-amino-functionalized-lipids-for-gene-transfection-the-protonation-state-in-monolayers-at-the-air-liquid-interface
#19
Stephanie Tassler, Christian Wölk, Christopher Janich, Bodo Dobner, Gerald Brezesinski
Cationic lipids are considered as non-viral carriers for genetic material used in gene therapy. They have no carcinogenic potential and cause low immune response compared to existing viral systems. The protonation degree of these cationic lipids is a crucial parameter for the binding behavior of polynucleotides (e.g., DNA). Newly synthesized peptide-mimic lysine-based amino-functionalized lipids have been investigated in 2D models as monolayers at the air-liquid interface. Standard surface pressure - area isotherms have been measured to prove the layer stability...
July 20, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28726855/cyclodextrin-based-biological-stimuli-responsive-carriers-for-smart-and-precision-medicine
#20
Rongqiang Liao, Pin Lv, Qian Wang, Jiaoni Zheng, Bing Feng, Bo Yang
Spurred on by recent progress in nanotechnology and precision medicine, smart drug carriers are entering an entirely new era. Smart drug carriers have been widely studied in recent years as a result of their ability to control drug release under different microenvironments (such as pH, redox, and enzyme) in vivo. Host-guest interactions based on cyclodextrins have proven to be an efficient tool for fabricating smart drug carriers. Because of the application of host-guest interactions, many kinds of biological molecules or supramolecular building blocks can combine into an organic whole at the molecular level...
July 20, 2017: Biomaterials Science
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