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https://www.readbyqxmd.com/read/29775789/e-coli-encoding-blandm-5-associated-with-community-acquired-uti-cases-with-unusual-mic-creep-like-phenomenon-against-imipenem
#1
Varsha Rani Gajamer, Amitabha Bhattacharjee, Deepjyoti Paul, Chandrayee Deshamukhya, Ashish Kr Singh, Nilu Pradhan, Hare Krishna Tiwari
OBJECTIVES: Carbapenemase-producing Escherichia coli are of major clinical concern. The present study aimed to identify NDM-5 producing E.coli associated with community-acquired urinary tract infection, co-harboring ESBL genes and a pattern of imipenem MIC creep. METHODS: A total of 973 urine samples were collected from females of age between 18-49 diagnosed with UTI. Isolates were identified by standard microbiological procedures. Presence of blaNDM and ESBL genes was determined by PCR assay and sequencing...
May 15, 2018: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29772393/unexpected-mechanisms-of-resistance-in-dutch-pseudomonas-aeruginosa-isolates-collected-during-fourteen-years-of-surveillance
#2
P D Croughs, C H W Klaassen, J van Rosmalen, D M Maghdid, S A Boers, J P Hays, W H F Goessens
Pseudomonas aeruginosa is one of the most important causes of infection in the intensive care unit. It is intrinsically resistant to many antibiotics and easily acquires additional resistance genes via horizontal gene transfer of mobile genetic elements. In the present study, 1,528 P. aeruginosa isolates, obtained from a Dutch national surveillance program between the years 1998 and 2011, were analyzed for the presence of Extended Spectrum β-Lactamase (ESBL) genes blaCTX-M , blaSHV , blaTEM , blaBEL , blaPER , blaVEB , blaOXA-10 and metallo-β-Lactamase (MBL) genes blaIMP , blaVIM and blaNDM ...
May 14, 2018: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/29769010/evaluation-of-fosfomycin-activity-against-esbl-producing-enterobacteriaceae-isolated-from-iran
#3
Hossein Kazemian
BACKGROUND: Rising rates of antimicrobial resistance among Enterobacteriaceae limit the use of reliably active forms of available drugs. The aim of this study was to investigate the prevalence of fosfomycin (US6794490B2) resistance gene among ESBL producing isolates in Iran. METHOD: We tested 355 isolates of Enterobacteriacea collected from various clinical samples including urine, wounds, blood and other sources during June 2016 to July 2017. Antibiotic sensitivity and extended spectrum beta lactamase (ESBL) production were tested using agar dilution method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines...
May 16, 2018: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29758886/carrier-flies-of-multidrug-resistant-escherichia-coli-as-potential-dissemination-agent-in-dairy-farm-environment
#4
Taila Dos Santos Alves, Gustavo Henrique Batista Lara, Renato Pariz Maluta, Márcio Garcia Ribeiro, Domingos da Silva Leite
The life cycle of synanthropic flies and their behavior, allows them to serve as mechanical vectors of several pathogens. Given that flies can carry multidrug-resistant (MDR) bacteria, this study aimed to investigate the spread of genes of antimicrobial resistance in Escherichia coli isolated from flies collected in two dairy farms in Brazil. Besides antimicrobial resistance determinants, the presence of virulence genes related to bovine colibacillosis was also assessed. Of 94 flies collected, Musca domestica was the most frequently found in the two farms...
August 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29757079/epidemiology-antimicrobial-resistance-and-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-clinical-bovine-mastitis-in-tunisia
#5
Mariem Saidani, Lilia Messadi, Alya Soudani, Monia Daaloul-Jedidi, Pierre Châtre, Faten Ben Chehida, Aymen Mamlouk, Wassim Mahjoub, Jean-Yves Madec, Marisa Haenni
Bovine mastitis is a major disease in dairy cattle that causes high economic losses annually. Staphylococci, streptococci, and coliforms are among the major pathogens responsible for such infections. While data on bovine mastitis are numerous in Europe where the efficacy of farm management was monitored, those are scarce in African countries. In this study, we reported the occurrence of Escherichia coli (118/372, 31.7%) and Klebsiella pneumoniae (77/372, 20.7%), two environmental pathogens known to cause bovine mastitis...
May 14, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29757009/molecular-and-phenotypic-analysis-of-hemolytic-aeromonas-strains-isolated-from-food-in-egypt-revealed-clinically-important-multidrug-resistance-and-virulence-profiles
#6
Ahmed M Hammad, Alaa-Eldin H Moustafa, Maha M Mansour, Bashier M Fahmy, Mohamed G Hamada, Toshi Shimamoto, Tadashi Shimamoto
The aim of this study was to determine the public health significance of hemolytic Aeromonas species isolated from 213 food samples in Egypt, based on their virulence and antimicrobial-resistance potential. We recovered 63 strains, isolated from fish, raw milk, karish cheeses, and ras cheese in 29 (31.18%) of 93, 10 (25.00%) of 40, 13 (32.50%) of 40, and 11 (27.50%) of 40 samples, respectively. The most prevalent virulence gene was alt (50.79%), followed by aerA (34.92%), asa1 (39.68%), ahh1 (20.63%), act (11...
May 14, 2018: Journal of Food Protection
https://www.readbyqxmd.com/read/29751417/occurrence-and-characteristics-of-extended-spectrum-%C3%AE-lactamase-and-carbapenemase-producing-bacteria-from-hospital-effluents-in-singapore
#7
Laurence Haller, Hongjie Chen, Charmaine Ng, Thai Hoang Le, Tse Hsien Koh, Timothy Barkham, Mark Sobsey, Karina Yew-Hoong Gin
One of the most important resistance mechanisms in Gram-negative bacteria today is the production of enzymes causing resistance to cephalosporin and carbapenem antibiotics. The spread of extended-spectrum β-lactamases (ESBL)- and carbapenemase- producing Gram-negative bacteria is an emerging global public health problem. The aim of the present study was to (i) assess the prevalence of carbapenem-resistant bacteria (CRB) and ESBL-producing strains in sewage effluents from two major hospitals in Singapore, (ii) characterize the isolated strains and (iii) identify some of the ESBL and carbapenemase genes responsible for the resistance...
February 15, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29750591/salmonella-species-persistence-and-their-high-level-of-antimicrobial-resistance-in-flooded-man-made-rivers-in-china
#8
Qifa Song, Danyang Zhang, Hong Gao, Junhua Wu
Man-made rivers, owing to proximity to human habitats, facilitate transmission of salmonellosis to humans. To determine the contamination situation by Salmonella in flooded man-made rivers and thereafter the exposure risk to public health, we investigated the prevalence of Salmonella species and their antimicrobial resistance in such rivers, as well as the relationship between the incidence of local infectious diarrhea cases and the number of Salmonella isolates from patients. After a heavy flood, 95 isolates of 13 Salmonella serotypes were isolated from 80 river water samples...
May 11, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29748922/defining-the-relationship-between-phenotypic-and-genotypic-resistance-profiles-of-multidrug-resistant-enterobacterial-clinical-isolates
#9
Lamis Galal, Neveen A Abdel Aziz, Walaa M Hassan
Fluoroquinolones and aminoglycosides offer effective therapy for extended-spectrum beta-lactamase (ESBL)-producing enterobacterial infections, but their usefulness is threatened by increasing resistant strains. OBJECTIVE: This study was conducted to demonstrate the phenotypic outcomes of the coexistence of genetic determinants mediating resistance to extended-spectrum cephalosporins and quinolones in enterobacterial isolates collected from patients with health-care-associated infections in Egypt...
May 11, 2018: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29743625/acquisition-and-dissemination-of-cephalosporin-resistant-e-coli-in-migratory-birds-sampled-at-an-alaska-landfill-as-inferred-through-genomic-analysis
#10
Christina A Ahlstrom, Jonas Bonnedahl, Hanna Woksepp, Jorge Hernandez, Björn Olsen, Andrew M Ramey
Antimicrobial resistance (AMR) in bacterial pathogens threatens global health, though the spread of AMR bacteria and AMR genes between humans, animals, and the environment is still largely unknown. Here, we investigated the role of wild birds in the epidemiology of AMR Escherichia coli. Using next-generation sequencing, we characterized cephalosporin-resistant E. coli cultured from sympatric gulls and bald eagles inhabiting a landfill habitat in Alaska to identify genetic determinants conferring AMR, explore potential transmission pathways of AMR bacteria and genes at this site, and investigate how their genetic diversity compares to isolates reported in other taxa...
May 9, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29735836/association-of-glycerol-kinase-gene-with-class-3-integrons-a-novel-cassette-array-within-escherichia-coli
#11
Rajkumari Elizabeth, Debadatta Dhar Chanda, Atanu Chakravarty, Deepjyoti Paul, Shiela Chetri, Deepshikha Bhowmik, Jayalaxmi Wangkheimayum, Amitabha Bhattacharjee
Background: Integrons are genetic elements which are known for their role in capturing and spreading of antibiotic resistance determinants among Gram-negative bacilli. So far, there is no study regarding Class 3 integron and their genetic organisation in India. Objective: This study investigates the occurrence of Class 3 integron and their gene cassette array among Escherichia coli. Materials and Methods: In this study, a total of 200 E. coli isolates were collected from indoor and outdoor patients from Silchar Medical College and Hospital during September 2015 to February 2016...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29735827/molecular-characterisation-for-clonality-and-transmission-dynamics-of-an-outbreak-of-klebsiella-pneumoniae-amongst-neonates-in-a-tertiary-care-centre-in-south-india
#12
Chaitra Shankar, Manish Kumar, Ashtawarthani Baskaran, Miracle Magdelene Paul, Nithya Ponmudi, Sridhar Santhanam, Joy Sarojini Michael, Balaji Veeraraghavan
Purpose: Sepsis is a significant cause of morbidity and mortality amongst neonates. Klebsiella pneumoniae is a common cause of nosocomial outbreaks causing bacteraemia and having potential of acquiring plasmids enhancing antimicrobial resistance. In the present study, we investigate K. pneumoniae outbreak causing bacteraemia amongst neonates over a span of 2 months. Isolates were characterised for antimicrobial resistance, virulence, molecular typing for clonality and plasmid typing for transmission dynamics, and patient outcome was investigated...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29733265/effects-of-cage-farming-on-antimicrobial-and-heavy-metal-resistance-of-escherichia-coli-enterococcus-faecium-and-lactococcus-garvieae
#13
Mustafa Ture, Ilhan Altinok, Huseyin Alp
OBJECTIVE: To characterize antibiotic resistance genes (ARGs) and heavy metal resistance genes (HMRGs) of Escherichia coli and Enterococcus faecium isolated from the sediment and Lactococcus garvieae isolated from fish. MATERIALS AND METHODS: The isolated bacteria were identified by sequencing 16S rRNA genes. After identification of the bacteria, tetracycline (tetA, tetB, tetD), erythromycin (ereA, ereB), sulfonamides (sulI, sulII), trimethoprim (dhfrA1), β-lactam (blaTEM , blaCTX , ampC), florfenicol (floR), and class 1 integron (Int1) resistance gene were then determined...
May 7, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29732983/an-outbreak-of-esbl-producing-klebsiella-pneumoniae-in-an-iranian-referral-hospital-epidemiology-and-molecular-typing
#14
Shima Mahmoudi, Babak Pourakbari, Aliakbar Rahbarimanesh, Mohammad Reza Abdolsalehi, Keyghobad Ghadiri, Setareh Mamishi
INTRODUCTION: Klebsiella pneumoniae is a common cause of nosocomial infections; however, there is limited information in Iran regarding nosocomial outbreaks due to extended-spectrum β-lactamase (ESBL) producing K pneumoniae strains, particularly using molecular methods. The present study focused on the molecular mechanism of ESBL resistance and genetic relatedness in K. pneumoniae isolates causing nosocomial infections in an Iranian referral hospital. MATERIAL AND METHODS: This study was evaluated the antimicrobial resistance and molecular epidemiology of K...
May 7, 2018: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29727265/prevalence-of-aminoglycoside-modifying-enzymes-in-escherichia-coli-and-klebsiella-pneumoniae-producing-extended-spectrum-%C3%AE-lactamases-collected-in-two-multicenter-studies-in-spain
#15
Marta Fernández-Martínez, Belén Ruiz Del Castillo, Maria Jesús Lecea-Cuello, Jesús Rodríguez-Baño, Álvaro Pascual, Luis Martínez-Martínez
The in vitro activity of amikacin, gentamicin, kanamycin, tobramycin, neomycin, and netilmicin against 420 Escherichia coli producing extended spectrum β-lactamases (Ec-ESBLs) and 139 Klebsiella pneumoniae producing extended spectrum β-lactamase (Kp-ESBL) collected in two multicenter studies performed in Spain in 2000 and 2006 was determined. The presence of genes encoding aminoglycoside-modifying enzymes (AMEs) and 16S ribosomal RNA (rRNA) methylases [aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-Ib, ant(2")-Ia, ant(4')-IIa, aph(3')-Ia, aph(3')-IIa, armA, rmtB, and rmtC] was also investigated...
May 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29710598/tracking-antibiotic-resistance-genes-in-soil-irrigated-with-dairy-wastewater
#16
Robert S Dungan, Chad W McKinney, April B Leytem
The application of dairy wastewater to agricultural soils is a widely used practice to irrigate crops and recycle nutrients. In this study, small-scale field plots were irrigated monthly (6 times) with dairy wastewater (100%), wastewater diluted to 50% with irrigation (canal) water, and diluted wastewater spiked with copper sulfate (50 mg Cu L-1 ), while control plots were irrigated with canal water. In addition, half of all plots were either planted with wheat or were left as bare soil. Biweekly soil samples were collected during this period and processed to determine the occurrence and abundance of antibiotic resistance genes [blaCTX-M-1 , erm(B), sul1, tet(B), tet(M), and tet(X)] and a class 1 integron-integrase gene (intI1) via quantitative real-time PCR (qPCR)...
April 24, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29708041/comparative-analysis-of-klebsiella-pneumoniae-strains-isolated-in-2012-2016-that-differ-by-antibiotic-resistance-genes-and-virulence-genes-profiles
#17
Anastasia I Lev, Eugeny I Astashkin, Angelina A Kislichkina, Ekaterina V Solovieva, Tatiana I Kombarova, Olga V Korobova, Olga N Ershova, Irina A Alexandrova, Vladimir E Malikov, Alexander G Bogun, Alexander I Borzilov, Nikolay V Volozhantsev, Edward A Svetoch, Nadezhda K Fursova
The antibacterial resistance and virulence genotypes and phenotypes of 148 non-duplicate Klebsiella pneumoniae strains collected from 112 patients in Moscow hospitals in 2012-2016 including isolates from the respiratory system (57%), urine (30%), wounds (5%), cerebrospinal fluid (4%), blood (3%), and rectal swab (1%) were determined. The majority (98%) were multidrug resistant (MDR) strains carrying blaSHV (91%), blaCTX-M (74%), blaTEM (51%), blaOXA (38%), and blaNDM (1%) beta-lactamase genes, class 1 integrons (38%), and the porin protein gene ompK36 (96%)...
April 30, 2018: Pathogens and Global Health
https://www.readbyqxmd.com/read/29701161/ferula-gummosa-boiss-inhibits-multi-drug-resistant-clinical-pseudomonas-aeruginosas
#18
Fereshteh Satarian, Hamideh Mahmoodzadeh Hosseini, Abdolamir Ghadaksaz, Mohsen Amin, Abbas Ali Imani Fooladi
BACKGROUND: Multi-drug resistance among Pseudomonas aeruginosa (P. aeruginosa) clinical isolates is increasing and becoming a serious problem for public health authorities worldwide. OBJECTIVE: The aim of current study is the introducing a potent antibacterial compound against the resistant P. aeruginosa. The recent patents on antimicrobial properties of extracts drived from Apiaceae family plants (WO2017216602A1, KR20050054247A and KR100285781B1) were used to to assess other member Ferula gummosa (F...
April 26, 2018: Recent Patents on Anti-infective Drug Discovery
https://www.readbyqxmd.com/read/29688801/genomic-characterization-of-nonclonal-mcr-1-positive-multidrug-resistant-klebsiella-pneumoniae-from-clinical-samples-in-thailand
#19
Apichai Srijan, Katie R Margulieux, Sirigade Ruekit, Erik Snesrud, Rosslyn Maybank, Oralak Serichantalergs, Rosarin Kormanee, Prawet Sukhchat, Jossin Sriyabhaya, Mary Hinkle, John M Crawford, Patrick McGann, Brett E Swierczewski
Multidrug-resistant Klebsiella pneumoniae strains are one of the most prevalent causes of nosocomial infections and pose an increasingly dangerous public health threat. The lack of remaining treatment options has resulted in the utilization of older drug classes, including colistin. As a drug of last resort, the discovery of plasmid-mediated colistin resistance by mcr-1 denotes the potential development of pandrug-resistant bacterial pathogens. To address the emergence of the mcr-1 gene, 118 gram-negative Enterobacteriaceae isolated from clinical samples collected at Queen Sirikit Naval Hospital in Chonburi, Thailand were screened for colistin resistance using automated antimicrobial susceptibility testing and conventional PCR screening...
April 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29685218/antimicrobial-usage-and-presence-of-extended-spectrum-%C3%AE-lactamase-producing-enterobacteriaceae-in-animal-rearing-households-of-selected-rural-and-peri-urban-communities
#20
Evelyn O Okpara, Olufemi E Ojo, Olajoju J Awoyomi, Morenike A Dipeolu, Mufutau A Oyekunle, Stefan Schwarz
This study examined socioeconomic and cultural factors relating to animal husbandry, antimicrobial usage and household hygiene in 320 animal-keeping households of 16 rural and peri-urban communities of Ogun State, Nigeria. The occurrence of extended-spectrum β-lactamase-producing Enterobacteriaceae in 457 samples from animal and environmental sources within the households was investigated. Chickens (41.6%), goats (35.3%), dogs (33.8%) and sheep (14.4%) were the most common household animals. Animals were reared mainly for income generation (73...
May 2018: Veterinary Microbiology
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