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https://www.readbyqxmd.com/read/27933141/emergence-of-serotype-k1-klebsiella-pneumoniae-st23-strains-co-producing-the-plasmid-mediated-ampc-beta-lactamase-dha-1-and-an-extended-spectrum-beta-lactamase-in-korea
#1
Hae Suk Cheong, Doo Ryeon Chung, Chaeyoeng Lee, So Hyun Kim, Cheol-In Kang, Kyong Ran Peck, Jae-Hoon Song
BACKGROUND: Serotype K1 Klebsiella pneumoniae has emerged as an important community pathogen causing various infections, including liver abscesses. Although serotype K1 K. pneumoniae community isolates have been reported as susceptible to most classes of antimicrobial agents, a few cases of infection caused by extended-spectrum beta-lactamase (ESBL)-producing serotype K1 K. pneumoniae have recently been reported in Asian countries. We identified three ESBL-producing strains of serotype K1 K...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27930267/frequency-of-antiseptic-resistance-genes-and-reduced-susceptibility-to-biocides-in-carbapenem-resistant-acinetobacter-baumannii
#2
Wen J Liu, Li Fu, Mei Huang, Jing P Zhang, Yang Wu, Ying S Zhou, Jing Zeng, Guang X Wang
The aim of this study is to determine the frequency of quaternary ammonium compound(QAC) resistant genes including qacA/B, qacC/D, qacE, qacΔE1, qacG, qacJ and β-lactamase genes including blaCTX-M, blaTEM, blaSHV, blaOXA-23, blaVIM, blaIMP, blaNDM, blaGIM in 51 isolates of carbapenem-resistant Acinetobacter baumannii collected over a period of 2 years, and to determine the minimum inhibitory concentration (MIC) of chlorhexidine(CLX) and QAC-based disinfectant benzalkonium chloride(BC). The qac and bla genes were detected by PCR method...
December 8, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27902398/clonal-spread-and-accumulation-of-beta-lactams-resistance-determinants-in-enterobacter-aerogenes-and-enterobacter-cloacae-complex-isolates-from-infection-and-colonization-in-patients-at-a-public-hospital-in-recife-pernambuco-brazil
#3
Adriane Borges Cabral, Maria Amélia Vieira Maciel, Josineide Ferreira Barros, Marcelo Maranhão Antunes, Célia Maria Machado Barbosa de Castro, Ana Catarina Souza Lopes
Enterobacter aerogenes and Enterobacter cloacae complex are the species of this genus most involved in healthcare-associated infections (HAIs), that are ESBL and carbapenemase producers. This study has characterized phenotypically and genotypically 51 isolates of E. aerogenes and E. cloacae complex as originated from infection or colonization in patients admitted to public hospital in Recife, Pernambuco, Brazil, by antimicrobial susceptibility profile, analysis of β-lactamase genes (blaTEM, blaSHV, blaCTX-M, blaKPC, blaVIM, blaIMP and blaSPM), PCR and DNA sequencing, plasmid profile and ERIC-PCR...
November 28, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27899921/high-prevalence-of-%C3%AE-lactamase-and-plasmid-mediated-quinolone-resistance-genes-in-extended-spectrum-cephalosporin-resistant-escherichia-coli-from-dogs-in-shaanxi-china
#4
Xiaoqiang Liu, Haixia Liu, Yinqian Li, Caiju Hao
Objective: The aim of this study was to investigate the occurrence and molecular characterization of extended-spectrum β-lactamases (ESBL), plasmid-mediated AmpC β-lactamase (pAmpC) and carbapenemases as well as plasmid-mediated quinolone-resistant (PMQR) among extended-spectrum cephalosporin-resistant (ESC-R) Escherichia coli from dogs in Shaanxi province in China. Methods: A total of 40 ESC-R Escherichia coli selected from 165 Extraintestinal pathogenic E. coli (ExPEC) isolated from dogs were screened and characterized for the genes encoding for the ESBLs, pAmpC, carbapenemases and PMQR genes by PCR and sequencing...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27895637/high-prevalence-of-esbl-producing-klebsiella-pneumoniae-causing-community-onset-infections-in-china
#5
Jing Zhang, Kai Zhou, Beiwen Zheng, Lina Zhao, Ping Shen, Jinru Ji, Zeqing Wei, Lanjuan Li, Jianying Zhou, Yonghong Xiao
The aim of this work was to investigate the epidemiological and genetic characteristics of ESBL-producing Klebsiella pneumoniae (ESBL-Kp) causing community-onset infections. K. pneumoniae isolates were collected from 31 Chinese secondary hospitals between August 2010 and 2011. Genes encoding ESBL and AmpC beta-lactamases were detected by PCR. The isolates were assigned to sequence types (STs) using multi-locus sequence typing (MLST). Eleven ESBL-Kp strains were selected for whole-genome sequencing (WGS) for investigating the genetic environment and plasmids encoding ESBL genes...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27894674/emergence-of-plasmid-mediated-colistin-resistance-and-new-delhi-metallo-%C3%AE-lactamase-genes-in-extensively-drug-resistant-escherichia-coli-isolated-from-a-patient-in-thailand
#6
Wantana Paveenkittiporn, Anusak Kerdsin, Sukanya Chokngam, Charatdao Bunthi, Somchai Sangkitporn, Christopher J Gregory
We reported a case of Escherichia coli with colistin resistance and an extensively drug-resistant phenotype. Molecular analysis revealed that the isolate carried mcr-1 and multiple β-lactamase genes includingblaNDM1, blaCTX-M-15, blaTEM1, and blaCMY-2. This is the first report of a clinical mcr-1 isolate in Thailand highlighting the urgent need for a comprehensive antimicrobial resistance containment strategy to prevent further spread.
November 14, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27889169/characterization-of-biocide-tolerant-bacteria-isolated-from-cheese-and-dairy-small-medium-enterprises
#7
Ma Luisa Fernández Márquez, Ma José Grande Burgos, Ma Carmen López Aguayo, Rubén Pérez Pulido, Antonio Gálvez, Rosario Lucas
A collection of 120 bacterial isolates from small medium enterprises involved in the production of cow milk and the manufacture of goat cheese were screened for sensitivity to biocides benzalkonium chloride (BC), cetrimide (CT), hexadecylpyridinium chloride (HDP), triclosan (TC), hexachlorophene (CF) and poly-(hexamethylen guanidinium) hydrochloride (PHMG). Nineteen isolates were selected according to biocide tolerance and identified by 16S rDNA sequencing as Lactococcus sp. (6) Enterococcus sp. (1), Lactobacillus sp...
April 2017: Food Microbiology
https://www.readbyqxmd.com/read/27872719/phylogenetic-typing-and-detection-of-extended-spectrum-%C3%AE-lactamases-in-escherichia-coli-isolates-from-broiler-chickens-in-ahvaz-iran
#8
Ramezan Ali Jafari, Hossein Motamedi, Elham Maleki, Reza Ghanbarpour, Mansoor Mayahi
This study was conducted to reveal the phylogenetic background, to detect the genes encoding TEM, SHV and CTX-M-15 extended-spectrum β-lactamases (ESBL), and to analyze their distribution in phylo-groups of 150 Escherichia coli isolates from broiler chickens in Ahvaz (Southwest of Iran). Seventy- five cloacal swabs from healthy birds (fecal isolates), and 75 heart blood samples from birds with colibacillosis (septicemic isolates) were obtained. All isolates were phylotyped and screened for ESBL genes by polymerase chain reaction (PCR)...
2016: Veterinary Research Forum
https://www.readbyqxmd.com/read/27870554/occurrence-of-extended-spectrum-%C3%AE-lactamases-plasmid-mediated-quinolone-resistance-and-disinfectant-resistance-genes-in-escherichia-coli-isolated-from-ready-to-eat-meat-products
#9
Lili Li, Lei Ye, Sofie Kromann, Hecheng Meng
There are growing concerns about the coselection of resistance against antibiotics and disinfectants in bacterial pathogens. The aim of this study was to characterize the antimicrobial susceptibility profiles, the prevalence of extended-spectrum β-lactamases (ESBLs), plasmid-mediated quinolone resistance genes (PMQRs), and quaternary ammonium compound resistance genes (QACs) in Escherichia coli isolated from ready-to-eat (RTE) meat products obtained in Guangzhou, China, and to determine whether these genes were colocalized in the isolates...
November 21, 2016: Foodborne Pathogens and Disease
https://www.readbyqxmd.com/read/27856044/community-fecal-carriage-of-broad-spectrum-cephalosporin-resistant-escherichia-coli-in-tunisian-children
#10
Sana Ferjani, Mabrouka Saidani, Zeineb Hamzaoui, Carla Andrea Alonso, Carmen Torres, Elaa Maamar, Amine Faouzi Slim, Ben Boubaker Ilhem Boutiba
The spread of extended spectrum β-lactamases (ESBL) and plasmid mediated AmpC β-lactamases (pAmpC) was evaluated in Escherichia coli strains collected from the intestinal microbiota of healthy children in Tunisia. The carriage rate of CTX(R)E. coli was 6.6% (7 of 105 samples) and one strain/sample was further characterized (7 isolates). These isolates harbored blaCTX-M-1 (n = 4), blaCTX-M-15 (n = 2), and blaCMY-2 gene (n = 1), which were usually located on FIB replicon type and carried class 1 integrons. The acc(6')-Ib-cr variant was identified in one isolate that harbored blaCTX-M-15...
March 8, 2016: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27834610/regional-spread-of-ctx-m-2-producing-proteus-mirabilis-with-the-identical-genetic-structure-in-japan
#11
Karin Kato, Yasufumi Matsumura, Masaki Yamamoto, Miki Nagao, Shunji Takakura, Satoshi Ichiyama
AIMS: In this study, we analyzed the molecular epidemiology of extended-spectrum β-lactamase (ESBL)-producing Proteus mirabilis isolates collected from the central region of Japan. MATERIALS AND METHODS: Between 2005 and 2012, 820 clinical P. mirabilis isolates were obtained from ten acute care hospitals in Japan. We characterized ESBL confirmatory test-positive isolates by sequencing the ESBL genes and their flanking regions, detecting plasmid replicons, and performing pulsed-field gel electrophoresis (PFGE)...
November 11, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27833607/complete-sequence-of-a-f33-a-b-conjugative-plasmid-carrying-the-oqxab-fosa3-and-blactx-m-55-elements-from-a-foodborne-escherichia-coli-strain
#12
Marcus H Wong, Miaomiao Xie, Liqi Xie, Dachuan Lin, Ruichao Li, Yuanjie Zhou, Edward W Chan, Sheng Chen
This study reports the complete sequence of pE80, a conjugative IncFII plasmid recovered from an Escherichia coli strain isolated from chicken meat. This plasmid harbors multiple resistance determinants including oqxAB, fosA3, blaCTX-M-55, and blaTEM-1, and is a close variant of the recently reported p42-2 element, which was recovered from E. coli of veterinary source. Recovery of pE80 constitutes evidence that evolution or genetic re-arrangement of IncFII type plasmids residing in animal-borne organisms is an active event, which involves acquisition and integration of foreign resistance elements into the plasmid backbone...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27828759/prevalence-of-extended-spectrum-%C3%AE-lactamases-ctx-m-8-and-ctx-m-2-producing-salmonella-serotypes-from-clinical-and-nonhuman-isolates-in-brazil
#13
Sueli Aparecida Fernandes, Carlos Henrique Camargo, Gabriela Rodrigues Francisco, Maria Fernanda Campagnari Bueno, Doroti Oliveira Garcia, Yohei Doi, Monique Ribeiro Tiba Casas
We characterized extended-spectrum β-lactamases (ESBL) enzymes among Salmonella strains isolated in Brazil from 2009 to 2014. Salmonella recovered from both clinical and nonhuman (food, poultry, and environment) sources were subjected to antimicrobial susceptibility testing. β-lactamases genes were detected by polymerase chain reaction/sequencing; plasmid profiles and transferability were assessed by S1-pulsed field gel electrophoresis (PFGE). Genetic diversity was evaluated by XbaI-PFGE. Out of 630 Salmonella strains screened, 46 displayed ESBL phenotype, distributed across 11 different serotypes...
November 9, 2016: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/27821452/ctx-m-190-a-novel-%C3%AE-lactamase-resistant-to-tazobactam-and-sulbactam-identified-in-an-escherichia-coli-clinical-isolate
#14
Zhen Shen, Baixing Ding, Yingmin Bi, Shi Wu, Su Xu, Xiaogang Xu, Qinglan Guo, Minggui Wang
A novel β-lactamase CTX-M-190, derived from CTX-M-55 by a single substitution Ser133Thr, was identified in a natural Escherichia coli clinical isolate. CTX-M-190 exhibited potent hydrolytic activity against cefotaxime with kcat/Km 14.5 μM(-1) s(-1) and was resistant to inhibition by β-lactamase inhibitors tazobactam and sulbactam with the 50% inhibitory concentrations 77- and 55-fold higher than those of CTX-M-55, respectively. blaCTX-M-190 was located within the genetic platform, ISEcp1-blaCTX-M-orf477, which was harbored by a 70kb IncI1 plasmid...
November 7, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27821357/evaluation-of-meat-fruit-and-vegetables-from-retail-stores-in-five-united-kingdom-regions-as-sources-of-extended-spectrum-beta-lactamase-esbl-producing-and-carbapenem-resistant-escherichia-coli
#15
L P Randall, M P Lodge, N C Elviss, F L Lemma, K L Hopkins, C J Teale, N Woodford
We determined the prevalence and types of extended-spectrum β-lactamase (ESBL)-producing and carbapenem-resistant Escherichia coli in raw retail beef, chicken, pork, fruit and vegetables in five UK regions in 2013-14. Raw meat (n=397), and fruit and vegetable samples (n=400) were purchased from retail stores in London, East Anglia, North West England, Scotland and Wales. Samples were tested for the presence of ESBL-producing E. coli by plating enriched samples on CHROMagar CTX and CHROMagar ESBL, for AmpC-type E...
October 29, 2016: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/27816836/characterization-of-ctx-m-enzymes-quinolone-resistance-determinants-and-antimicrobial-residues-from-hospital-sewage-wastewater-treatment-plant-and-river-water
#16
Danieli Conte, Jussara Kasuko Palmeiro, Keite da Silva Nogueira, Thiago Marenda Rosa de Lima, Marco André Cardoso, Roberto Pontarolo, Flávia Lada Degaut Pontes, Libera Maria Dalla-Costa
Multidrug-resistant (MDR) bacteria are widespread in hospitals and have been increasingly isolated from aquatic environments. The aim of the present study was to characterize extended-spectrum β-lactamase (ESBL) and quinolone-resistant Enterobacteriaceae from a hospital effluent, sanitary effluent, inflow sewage, aeration tank, and outflow sewage within a wastewater treatment plant (WWTP), as well as river water upstream and downstream (URW and DRW, respectively), of the point where the WWTP treated effluent was discharged...
February 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27814552/abundance-of-antibiotic-resistance-genes-in-five-municipal-wastewater-treatment-plants-in-the-monastir-governorate-tunisia
#17
Ikbel Denden Rafraf, Itziar Lekunberri, Alexandre Sànchez-Melsió, Mahjoub Aouni, Carles M Borrego, José Luis Balcázar
Antimicrobial resistance is a growing and significant threat to global public health, requiring better understanding of the sources and mechanisms involved in its emergence and spread. We investigated the abundance of antibiotic resistance genes (ARGs) before and after treatment in five wastewater treatment plants (WWTPs) located in different areas of the Monastir Governorate (Tunisia). Three of these WWTPs (Frina, Sahline and Zaouiet) use a conventional activated sludge process as secondary treatment, whereas the WWTP located in Beni Hassen applies an ultraviolet disinfection step after the activated sludge process and the WWTP located in Moknine treats wastewater using naturally aerated lagoons as a secondary treatment process...
October 28, 2016: Environmental Pollution
https://www.readbyqxmd.com/read/27795467/bloodstream-infection-due-to-ctx-m-15-and-tem-1-extended-spectrum-%C3%AE-lactamase-producing-salmonella-enterica-serovar-virchow-st16
#18
Jeong-Hwan Hwang, Gee-Wook Shin, Joo-Hee Hwang, Chang-Seop Lee
A 57-year-old man presented with a high fever and diarrhea. A blood culture showed the presence of a Group C nontyphoidal Salmonella isolate. On Salmonella serotyping, the isolate was Salmonella enterica serovar Virchow. Its sequence type was determined to be ST16 by sequence analysis of seven different housekeeping genes. The blaCTX-M group 1 and blaTEM genes were amplified by multiplex PCR assays for detecting ESBL genes. Sequences of both amplicons were respectively identical to CTX-M-15- and TEM-1-encoding genes...
October 31, 2016: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/27795372/escherichia-coli-probiotic-strain-ed1a-in-pigs-has-a-limited-impact-on-the-gut-carriage-of-extended-spectrum-beta-lactamase-producing-e-coli
#19
G Mourand, F Paboeuf, M A Fleury, E Jouy, S Bougeard, E Denamur, I Kempf
Four trials were conducted to evaluate the impact of Escherichia coli probiotic strain ED1a (EcED1a) administration to pigs on the gut carriage or survival in manure of extended-spectrum beta-lactamase-producing E. coli Groups of pigs were orally inoculated with strain E. coli M63 (EcM63) carrying the blaCTX-M-1 gene (n=84) or used as control (n=26). In the first two trials, eight days later, 24 of 40 EcM63 inoculated pigs were given EcED1a orally for six days. In the third trial, 10 EcM63 inoculated pigs were given either EcED1a or probiotic E...
October 17, 2016: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/27795239/draft-genome-sequence-of-an-escherichia-coli-strain-isolated-from-a-gallus-gallus-broiler-producing-the-novel-ctx-m-166-variant
#20
Vera Manageiro, Lurdes Clemente, Sílvia Duarte, Luís Vieira, Manuela Caniça
We report here the draft genome sequence of the CTX-M-166-harboring O6:H16 sequence type 48 (ST48)-fimH34 Escherichia coli strain recovered from a Gallus gallus broiler. Sequence analyses revealed the presence of an IncI1/ST103-ISEcp1-blaCTX-M-166-orf477 plasmid region and of diverse antibiotic resistance and virulence-acquired genes.
October 6, 2016: Genome Announcements
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