keyword
MENU ▼
Read by QxMD icon Read
search

BlaCtx

keyword
https://www.readbyqxmd.com/read/28735317/genetic-characterization-of-a-novel-composite-transposon-carrying-arma-and-aac-6-ib-genes-in-an-escherichia-coli-isolate-from-egypt
#1
Mona T Kashef, Omneya M Helmy
Aminoglycosides are used in treating a wide range of infections caused by Gram-positive and Gram-negative bacteria; however, aminoglycoside resistance is common and occurs by several mechanisms. Among these mechanisms is bacterial rRNA methylation by the 16S rRNA methyl transferase (16S-RMTase) enzymes; but data about the spread of this mechanism in Egypt are scarce. Cephalosporins are the most commonly used antimicrobial agents in Egypt; therefore, this study was conducted to determine the frequency of 16S-RMTase among third generation cephalosporin-resistant clinical isolates in Egypt...
July 6, 2017: Polish Journal of Microbiology
https://www.readbyqxmd.com/read/28728058/high-prevalence-of-esbls-in-retail-chicken-meat-despite-reduced-use-of-antimicrobials-in-chicken-production-france
#2
Tiago Casella, Mara Correa Lelles Nogueira, Estelle Saras, Marisa Haenni, Jean-Yves Madec
Extended-spectrum cephalosporins (ESCs) are critically important antibiotics for humans and their use in animals poses a potential threat for public health. Chicken represents an increasing part of the human diet and has also been regarded as a source of ESC-resistant Enterobacteriaceae because of the worldwide off-label use of ceftiofur, a broad-spectrum cephalosporin. Thus, numerous studies pointed out chicken as a reservoir of ESBL/pAmpC genes, plasmids and/or clones at risk for humans. In France, late 2011, strong political pressure led to a drastic reduction of ceftiofur use and all other antibiotics in chicken production...
July 10, 2017: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/28725196/synergistic-effect-of-doripenem-and-cefotaxime-to-inhibit-ctx-m-15-type-%C3%AE-lactamases-biophysical-and-microbiological-views
#3
Lubna Maryam, Asad U Khan
CTX-M-15 type β-lactamase has the ability to hydrolyse cefotaxime, a third generation cephalosporin. The infections caused by multidrug resistant strains, especially CTX-M-15 producing strains are being treated with carbapenem group of β-lactam antibiotics. The objective of the study was to know if cefotaxime in combination with doripenem (carbapemen antibiotic) at very low concentration, inhibits the CTX-M-15 producing bacterial strains. blaCTX-M-15 gene was cloned to express CTX-M-15 enzyme and construct CTX-M-15 producing strain...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28720731/an-in-vitro-chicken-gut-model-demonstrates-transfer-of-a-multidrug-resistance-plasmid-from-salmonella-to-commensal-escherichia-coli
#4
Roderick M Card, Shaun A Cawthraw, Javier Nunez-Garcia, Richard J Ellis, Gemma Kay, Mark J Pallen, Martin J Woodward, Muna F Anjum
The chicken gastrointestinal tract is richly populated by commensal bacteria that fulfill various beneficial roles for the host, including helping to resist colonization by pathogens. It can also facilitate the conjugative transfer of multidrug resistance (MDR) plasmids between commensal and pathogenic bacteria which is a significant public and animal health concern as it may affect our ability to treat bacterial infections. We used an in vitro chemostat system to approximate the chicken cecal microbiota, simulate colonization by an MDR Salmonella pathogen, and examine the dynamics of transfer of its MDR plasmid harboring several genes, including the extended-spectrum beta-lactamase blaCTX-M1 We also evaluated the impact of cefotaxime administration on plasmid transfer and microbial diversity...
July 18, 2017: MBio
https://www.readbyqxmd.com/read/28713357/extensively-drug-resistant-klebsiella-pneumoniae-causing-nosocomial-bloodstream-infections-in-china-molecular-investigation-of-antibiotic-resistance-determinants-informing-therapy-and-clinical-outcomes
#5
Wenzi Bi, Haiyang Liu, Rhys A Dunstan, Bin Li, Von Vergel L Torres, Jianming Cao, Lijiang Chen, Jonathan J Wilksch, Richard A Strugnell, Trevor Lithgow, Tieli Zhou
The rise in diversity of antimicrobial resistance phenotypes seen in Klebsiella pneumoniae is becoming a serious antibiotic management problem. We sought to investigate the molecular characteristics and clinical implications of extensively drug-resistant (XDR) K. pneumoniae isolated from different nosocomial bloodstream infections (BSIs) patients from July 2013 to November 2015. Even in combination treatment, meropenem did not protect against mortality of BSIs patients (P = 0.015). In contrast, tigecycline in combination with other antimicrobial agents significantly protected against mortality (P = 0...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28711559/outbreak-of-colistin-resistant-carbapenemase-producing-klebsiella-pneumoniae-in-tunisia
#6
Wejdène Mansour, Marisa Haenni, Estelle Saras, Raoudha Grami, Yosra Mani, Anis Ben Haj Khalifa, Souhail El Atrouss, Mohamed Kheder, Mohamed Fekih Hassen, Noureddine Boujâafar, Olfa Bouallegue, Jean-Yves Madec
OBJECTIVES: Mechanisms of colistin and carbapenem resistance among a collection of Klebsiella pneumoniae isolates recovered in a university hospital in Tunisia were studied. METHODS: In vitro antimicrobial susceptibility testing, S1 nuclease pulsed-field gel electrophoresis (S1-PFGE), Southern blotting and PCR-based replicon typing (PBRT) were performed. Extended-spectrum β-lactamases (ESBLs), carbapenemases, AmpC-type enzymes and mgrB genes were detected by PCR and sequencing...
July 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28711438/citrobacter-freundii-bacteremia-risk-factors-of-mortality-and-prevalence-of-resistance-genes
#7
Li-Hsiang Liu, Nai-Yu Wang, Alice Ying-Jung Wu, Chih-Chen Lin, Chun-Ming Lee, Chang-Pan Liu
BACKGROUND/PURPOSE: Multidrug-resistant strains of Citrobacter have emerged, which carry Amp-C β-lactamase (Amp-C), broad-spectrum β-lactamase, extended-spectrum β-lactamase (ESBL), and other resistance mechanisms. These strains are associated with a higher rate of in-hospital mortality. The object of this study is to determine the mortality risk factors, susceptibility pattern to antibiotics, and prevalence of resistance genes in patients with Citrobacter freundii bacteremia. METHODS: From January 2009 to December 2014, blood isolates of C...
June 22, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28709901/multicenter-collaboration-study-on-the-%C3%AE-lactam-resistant-enterobacteriaceae-in-japan-the-65th-anniversary-public-interest-purpose-project-of-the-japanese-society-of-chemotherapy
#8
Yoshikazu Ishii, Kotaro Aoki, Kazuhiro Tateda, Hiroshi Kiyota
This study was conducted using the same method of the "1-day multicenter collaborative research for Clostridium difficile infectious". This surveillance study was performed by 38 participating medical facilities across Japan. Of the 268 fecal specimens collected in this study, 5 (1.9%) carbapenem-resistant Enterobacteriaceae (CRE) were judged carbapenem resistant by the criteria of the Infectious Disease Act, Japan (2 mg/L or more and 64 mg/L or more MICs for imipenem and cefmetazole, respectively). However, no isolate was shown to have a meropenem MIC of 2 mg/L or more...
July 11, 2017: Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy
https://www.readbyqxmd.com/read/28707597/detection-of-extended-spectrum-beta-lactamases-esbls-and-antibiotic-susceptibility-patterns-in-klebsiella-pneumoniae-in-western-iran
#9
Pegah Shakib, Rashid Ramazan Zadeh, Morovat Taherikalani, Bijan Nouri
BACKGROUND: Production of Beta-Lactamase enzymes, especially extended-spectrum Beta -Lactamases (ESBL), is a primary mechanism of resistance in these bacteria. The purpose of this study was detection of blaTEM, blaSHV, blaCTX-M, blaCTX-M-15, blaPER and blaVEB in K. pneumoniae, isolated from clinical specimens by the PCR method and antibiotic susceptibility patterns in these strains isolated, in Sanandaj city, Iran. MATERIALS AND METHODS: During a period from October 2015 to July 2016, 52 K...
July 13, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/28698668/salmonella-enterica-serovar-typhimurium-st34-co-expressing-blandm-5-and-blactx-m-55-isolated-in-china
#10
Lang Yang, Xiaofeng Hu, Xuebin Xu, Chaojie Yang, Jing Xie, Rongzhang Hao, Xinying Du, Ligui Wang, Leili Jia, Peng Li, Shaofu Qiu, Hongbin Song
No abstract text is available yet for this article.
July 12, 2017: Emerging Microbes & Infections
https://www.readbyqxmd.com/read/28690880/the-prevalence-of-ctx-m-15-extended-spectrum-%C3%AE-lactamases-among-salmonella-spp-and-shigella-spp-isolated-from-three-iranian-hospitals
#11
Abed Zahedi Bialvaei, Tala Pourlak, Mina Aghamali, Mohammad Asgharzadeh, Pourya Gholizadeh, Hossein Samadi Kafil
Bacterial antimicrobial resistance mediated by the production of extended-spectrum β-lactamases (ESBLs) is considered a major threat for treatment of Salmonella and Shigella infections. This study aimed to investigate antibiotic resistance patterns of Salmonella and Shigella spp. and presence of CTX-M from three teaching hospitals in Iran. In the present study, 58 clinical Shigella and 91 Salmonella isolates were recovered between 2009 and 2013 from 3 teaching hospitals in Iran. After culture and antimicrobial susceptibility testing, ESBL-positive isolates were subjected to further investigations...
June 2017: European Journal of Microbiology & Immunology
https://www.readbyqxmd.com/read/28689895/plasmid-mediated-transfer-of-ctx-m-55-extended-spectrum-beta-lactamase-among-different-strains-of-salmonella-and-shigella-spp-in-the-republic-of-korea
#12
Jin Seok Kim, Soojin Kim, Jungsun Park, Eunkyung Shin, Young-Sun Yun, Deog-Yong Lee, Hyo-Sun Kwak, Won Keun Seong, Gyung Tae Chung, Junyoung Kim
We screened 10 CTX-M-55-producing Shigella and Salmonella isolates from a national surveillance in Korea. The blaCTX-M-55 was located on the IncI1 (n=5), IncA/C (n=4) and IncZ (n=1) plasmids, downstream of ISEcp1, IS26-ISEcp1 and ISEcp1-IS5 sequences, respectively. These results indicate that CTX-M-55 has disseminated to other bacteria by lateral plasmid transfer.
March 30, 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/28688673/characterization-of-phebe7-an-incfii-type-virulence-resistance-plasmid-carrying-blactx-m-98b-blatem-1-and-rmtb-genes-detected-in-escherichia-coli-from-a-chicken-isolate-in-china
#13
Yan-Xian Yang, Yong-Qiang Yang, Chang-Wei Lei, Bi-Hui Liu, Wei Jiang, Hong-Ning Wang, Maria Consuelo Gazitúa, An-Yun Zhang
Recently, a novel variant of the CTX-M enzyme, CTX-M-98, was detected in Escherichia coli isolates from food animals. However, few plasmids carrying blaCTX-M-98 have been fully characterized. In this study, we sequenced the complete pHeBE7 plasmid, an 86,015-bp plasmid that contains the blaCTX-M-98b, blaTEM-1, rmtB, and traT genes, using whole-genome sequencing. The backbone of pHeBE7 shows a high similarity (>99%) to pMC-NDM, which carries the blaNDM-1 gene, however its mosaic regions remain relatively unique among sequenced plasmids...
July 6, 2017: Plasmid
https://www.readbyqxmd.com/read/28683526/characteristics-of-transmissible-ctx-m-and-cmy-type-%C3%AE-lactamase-producing-escherichia-coli-isolates-collected-from-pig-and-chicken-farms-in-south-korea
#14
Seung Won Shin, Myunghwan Jung, Ho Geun Won, Kuastros Mekonnen Belaynehe, In Joong Yoon, Han Sang Yoo
The rapid dissemination Extended-spectrum β-lactamase (ESBL)-producing Escherichia coli has significantly contributed to hazard of public health globally. A total of 281 E. coli strains recovered from pigs and chickens between 2009 and 2015 in South Korea were analyzed for ESBL-production. ESBL phenotypes were recognized in 14 E. coli isolates; ten and three ESBL-producing isolates carried only blaCTX-M and blaCMY genes, respectively, and one isolate harbored both genes. The predominant CTX-M- and CMY-types were CTX-M-15 (n=8) and CMY-2 (n=3)...
July 7, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28680418/serotype-distribution-antimicrobial-resistance-and-class-1-integrons-profiles-of-salmonella-from-animals-in-slaughterhouses-in-shandong-province-china
#15
Xiaonan Zhao, Chaoqun Ye, Weishan Chang, Shuhong Sun
The current study aimed to analyze the prevalence and characterization of Salmonella enterica isolated from animals in slaughterhouses before slaughter. A total of 143 non-duplicate Salmonella were recovered from 1,000 fresh fecal swabs collected from four major pig slaughterhouses (49/600, 8.2%) and four major chicken slaughterhouses (94/400, 23.5%) between March and July 2016. Among Salmonella isolates from pigs, the predominant serovars were Salmonella Rissen (28/49, 57.1%) and Typhimurium (14/49, 28.6%), and high antimicrobial resistance rates were observed for tetracycline (44/49, 89...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28674313/first-detection-of-escherichia-coli-harboring-mcr-1-gene-from-retail-domestic-chicken-meat-in-japan
#16
Yusuke Ohsaki, Wataru Hayashi, Satomi Saito, Shunsuke Osaka, Yui Taniguchi, Shota Koide, Kumiko Kawamura, Yukiko Nagano, Yoshichika Arakawa, Noriyuki Nagano
Global spread of plasmid-mediated colistin resistance gene, mcr-1 poses a public health concern because colistin is the last-line-of-defense against severe infections due to multidrug-resistant Gram- negative bacteria. In Japan, a few studies have reported the prevalence of mcr-1 among food animal-derived Escherichia coli isolates, but the epidemiology of mcr-1 from retail meats is not well known. We report here the first detection of mcr-1 from retail chicken meats. A total of 70 ESBL-producing E. coli isolates recovered from retail chicken meats collected between August 2015 and June 2016 were screened for mcr-1, which resulted in positive for one isolate of CTX-M-1 producing E...
July 1, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28674050/plasmids-of-diverse-inc-groups-disseminate-the-fosfomycin-resistance-gene-fosa3-among-escherichia-coli-from-pigs-chickens-and-dairy-cows-in-northeast-china
#17
Xiu-Mei Wang, Zhimin Dong, Stefan Schwarz, Yao Zhu, Xin Hua, Yanhe Zhang, Siguo Liu, Wan-Jiang Zhang
Thirty-nine fosfomycin-resistant E. coli isolates carrying fosA3 were obtained from pigs, chickens, dairy cows and staff in four Northeastern provinces of China during 06/2015-04/2016. The fosA3 was co-located with blaCTX-M genes on conjugative plasmids of the incompatibility groups IncN (n=12), IncN-F33:A-:B- (n=2), IncF33:A-:B- (n=14), IncF14:A-:B- (n=2), and IncI1/ST136 (n=9). Four different genetic contexts of fosA3 were detected among the 39 E. coli isolates. Three potential epidemic plasmids circulated among E...
July 3, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28670975/carbapenem-resistant-klebsiella-pneumoniae-isolated-from-bloodstream-infection-indian-experience
#18
Balaji Veeraraghavan, Chaitra Shankar, Susmitha Karunasree, Shantha Kumari, Raji Ravi, Ravikar Ralph
Increased incidence of multidrug resistant (MDR) Gram negative infection has resulted in high rates of morbidity and mortality. Klebsiella pneumoniae is one of the commonest MDR pathogens causing bacteraemia with limited therapeutic options such as colistin and tigecycline. Present study focused on molecular characterisation of MDR K. pneumoniae from bloodstream infection and their clinical outcome. A total of 115 K. pneumoniae from January 2015 to September 2016 were included in the study which comprised of phenotypically identified ESBL and carbapenem resistant (CR) isolates...
July 2, 2017: Pathogens and Global Health
https://www.readbyqxmd.com/read/28661465/antibiotic-resistance-and-antibiotic-resistance-genes-in-escherichia-coli-isolates-from-hospital-wastewater-in-vietnam
#19
La Thi Quynh Lien, Pham Thi Lan, Nguyen Thi Kim Chuc, Nguyen Quynh Hoa, Pham Hong Nhung, Nguyen Thi Minh Thoa, Vishal Diwan, Ashok J Tamhankar, Cecilia Stålsby Lundborg
The environmental spread of antibiotic-resistant bacteria has been recognised as a growing public health threat for which hospitals play a significant role. The aims of this study were to investigate the prevalence of antibiotic resistance and antibiotic resistance genes (ARGs) in Escherichia coli isolates from hospital wastewater in Vietnam. Wastewater samples before and after treatment were collected using continuous sampling every month over a year. Standard disk diffusion and E-test were used for antibiotic susceptibility testing...
June 29, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28652231/complete-dna-sequence-of-incm1-plasmid-bearing-the-novel-qnre1-pmqr-variant-and-blactx-m-8-from-klebsiella-pneumoniae-st147
#20
Marcos P V Cunha, Yame M Davies, Louise Cerdeira, Milena Dropa, Nilton Lincopan, Terezinha Knöbl
The recent article by Albornoz et al. (1), reported a member of a new family of plasmid-mediated quinolone resistance genes, named qnrE1, originating from the chromosome of Enterobacter spp.….
June 26, 2017: Antimicrobial Agents and Chemotherapy
keyword
keyword
57661
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"