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https://www.readbyqxmd.com/read/29371068/treating-chlamydial-infections-in-pregnancy-and-preventing-adverse-birth-outcomes
#1
Paul C Adamson, Jeffrey D Klausner
No abstract text is available yet for this article.
January 19, 2018: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29367246/human-papillomavirus-16-e7-stabilizes-apobec3a-protein-by-inhibiting-cullin-2-dependent-protein-degradation
#2
Joseph A Westrich, Cody J Warren, Michael J Klausner, Kejun Guo, Changwei Liu, Mario L Santiago, Dohun Pyeon
APOBEC3 (A3) mutation signatures have been observed in a variety of human cancer genomes, including cervical and head and neck cancers caused by human papillomavirus (HPV) infection. However, the driving forces that promote off-target A3 activity remain mostly unclear. Here, we report a mechanism for the dramatic increase of A3A protein levels in HPV-positive keratinocytes. We show that expression of the viral protein E7 from high-risk HPVs, but not low-risk HPVs, significantly prolongs the cellular half-life of A3A protein in human keratinocytes and HPV-positive cancer cell lines...
January 24, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29354653/comparison-of-2d-and-3d-ultrasound-methods-to-measure-serial-bladder-volumes-during-filling-steps-toward-development-of-non-invasive-ultrasound-urodynamics
#3
Anna S Nagle, Rachel J Bernardo, Jary Varghese, Laura R Carucci, Adam P Klausner, John E Speich
OBJECTIVES: Non-invasive methods to objectively characterize overactive bladder (OAB) and other forms of voiding dysfunction using real-time ultrasound are currently under development but require accurate and precise serial measurements of bladder volumes during filling. This study's objective was to determine the most accurate and precise ultrasound-based method of quantifying serial bladder volumes during urodynamics (UD). METHODS: Twelve female participants with OAB completed an extended UD procedure with the addition of serial bladder ultrasound images captured once per minute...
2018: Bladder
https://www.readbyqxmd.com/read/29329176/a-cost-analysis-of-gyrase-a-testing-and-targeted-ciprofloxacin-therapy-versus-recommended-2-drug-therapy-for-neisseria-gonorrhoeae-infection
#4
Lao-Tzu Allan-Blitz, Peera Hemarajata, Romney M Humphries, Adriane Wynn, Eddy R Segura, Jeffrey D Klausner
BACKGROUND: Novel approaches to combating drug-resistant Neisseria gonorrhoeae infections are urgently needed. Targeted therapy with ciprofloxacin has been made possible by a rapid assay for genotyping the gyrase A (gyrA) gene; a nonmutated gene reliably predicts susceptibility to ciprofloxacin. METHODS: We determined the costs of running the gyrA assay, 500 mg of ciprofloxacin, 250 mg of ceftriaxone injection, and 1000 mg of azithromycin. Cost estimates for gyrA testing included assay reagents and labor...
February 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29315111/the-growing-epidemic-of-sexually-transmitted-infections-in-adolescents-a-neglected-population
#5
Chelsea L Shannon, Jeffrey D Klausner
PURPOSE OF REVIEW: Sexually transmitted infection (STI) incidence is on the rise in the United States. The increase is especially pronounced in adolescents (15-24 years of age). Despite making up only a quarter of the population, adolescents account for approximately half of new STIs in the United States every year. This review summarizes recent developments in the field of STIs, excluding HIV, in adolescents. RECENT FINDINGS: In this review, we examine the epidemiology, screening, management, and prevention of STIs in adolescents...
February 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29313193/the-relationship-between-risk-perception-and-frequency-of-hiv-testing-among-men-who-have-sex-with-men-and-transgender-women-lima-peru
#6
S K Vargas, K A Konda, S R Leon, B Brown, J D Klausner, C Lindan, C F Caceres
HIV infections in Peru are concentrated among men who have sex with men (MSM) and transgender women (TW). HIV testing rates among them remain low, delaying entrance into care. We assessed the prevalence of frequent HIV testing (at least every 6 months) and associated factors among 310 MSM and TW who attend sexual health clinics in Lima, Peru, and who reported that they were HIV seronegative or unaware of their status. Only 39% of participants tested frequently, and 22% had never tested; 29% reported that they were at low or no risk for acquiring HIV...
January 8, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29304083/combined-evaluation-of-sexually-transmitted-infections-in-hiv-infected-pregnant-women-and-infant-hiv-transmission
#7
Kristina Adachi, Jiahong Xu, Nava Yeganeh, Margaret Camarca, Mariza G Morgado, D Heather Watts, Lynne M Mofenson, Valdilea G Veloso, Jose Henrique Pilotto, Esau Joao, Glenda Gray, Gerhard Theron, Breno Santos, Rosana Fonseca, Regis Kreitchmann, Jorge Pinto, Marisa M Mussi-Pinhata, Mariana Ceriotto, Daisy Maria Machado, Yvonne J Bryson, Beatriz Grinsztejn, Jack Moye, Jeffrey D Klausner, Claire C Bristow, Ruth Dickover, Mark Mirochnick, Karin Nielsen-Saines
BACKGROUND: Sexually transmitted infections (STIs) including Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), Treponema pallidum (TP), and cytomegalovirus (CMV) may lead to adverse pregnancy and infant outcomes. The role of combined maternal STIs in HIV mother-to-child transmission (MTCT) was evaluated in mother-infant pairs from NICHD HPTN 040. METHODOLOGY: Urine samples from HIV-infected pregnant women during labor were tested by polymerase chain reaction (PCR) for CT, NG, and CMV...
2018: PloS One
https://www.readbyqxmd.com/read/29275831/-advances-in-the-management-of-cervical-lymphadenopathies-of-unknown-primary-advances-in-diagnostic-imaging-and-surgical-modalities-and-new-international-staging-system
#8
REVIEW
Idriss Troussier, Guillaume Klausner, Sylvain Morinière, Eivind Blais, Jean-Christophe Faivre, Ambroise Champion, Lionnel Geoffrois, Carole Pflumio, Emmanuel Babin, Philippe Maingon, Juliette Thariat
INTRODUCTION: Cervical lymphadenopathies of unknown primary represent 3 % of head and neck cancers. Their diagnostic work up has largely changed in recent years. This review provides an update on diagnostic developments and their potential therapeutic impact. MATERIALS AND METHODS: This is a systematic review of the literature. RESULTS: In recent years, changes in epidemiology-based prognostic factors such as human papilloma virus (HPV) cancers, advances in imaging and minimally invasive surgery have been integrated in the management of cervical lymphadenopathies of unknown primary...
December 21, 2017: Bulletin du Cancer
https://www.readbyqxmd.com/read/29240781/comparing-mail-in-self-collected-specimens-sent-via-united-states-postal-service-versus-clinic-collected-specimens-for-the-detection-of-chlamydia-trachomatis-and-neisseria-gonorrhoeae-in-extra-genital-sites
#9
Katheryn R Salow, Adam C Cohen, Claire C Bristow, Mark R McGrath, Jeffrey D Klausner
OBJECTIVES: To evaluate the concordance between clinic-collected extra-genital specimens and self-collected mailed-in extra-genital specimens among participants seeking sexually transmitted infection testing at a free clinic in Hollywood, CA. METHODS: A convenience sample of 210 men who have sex with men were enrolled between February 29, 2016 and December 21, 2016 and received mail-in testing kits for Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG). All testing was performed using the GeneXpert® CT/NG (Cepheid, Sunnyvale, CA)...
2017: PloS One
https://www.readbyqxmd.com/read/29239823/getting-hiv-self-test-kits-into-the-home-for-young-african-american-msm-in-los-angeles-a-qualitative-report
#10
Joseph Daniels, Robert Marlin, Alex Medline, Greg Wilson, Sean Young, Lina Rosengren, Emily Huang, Jeffrey D Klausner
No abstract text is available yet for this article.
October 10, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/29223960/systematic-reviews-of-point-of-care-tests-for-the-diagnosis-of-urogenital-chlamydia-trachomatis-infections
#11
REVIEW
Helen Kelly, Cordelia E M Coltart, Nitika Pant Pai, Jeffrey D Klausner, Magnus Unemo, Igor Toskin, Rosanna W Peeling
BACKGROUND: WHO estimates that 131 million new cases of urogenital Chlamydia trachomatis (CT) infections occur globally every year. Most infections are asymptomatic. Untreated infection in women can lead to severe complications. Screening and treatment of at-risk populations is a priority for prevention and control. OBJECTIVES: To summarise systematic reviews of the performance characteristics of commercially available point-of-care tests (POCT) for screening and diagnosis of urogenital CT infection...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29223959/performance-and-operational-characteristics-of-point-of-care-tests-for-the-diagnosis-of-urogenital-gonococcal-infections
#12
REVIEW
Rebecca J Guy, Louise M Causer, Jeffrey D Klausner, Magnus Unemo, Igor Toskin, Anna M Azzini, Rosanna W Peeling
BACKGROUND: In 2012, there was an estimated 78 million new cases of gonorrhoea globally. Untreated infection may lead to reproductive and neonatal morbidity and facilitate HIV transmission. Diagnosis and treatment are a priority for control and prevention, yet use of point-of-care tests (POCTs) for Neisseria gonorrhoeae (NG) is limited. OBJECTIVES: To review the performance and operational characteristics of NG POCTs for diagnosis of urogenital gonorrhoea. METHODS: We compiled and synthesised findings from two separate systematic reviews which included evaluations published until August 2015...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29198751/diabetes-resolution-after-one-anastomosis-gastric-bypass
#13
Adam Abu-Abeid, Yonatan Lessing, Niv Pencovich, Danit Dayan, Joseph M Klausner, Subhi Abu-Abeid
BACKGROUND: Diabetes and other obesity-related diseases are a worldwide pandemic that transcends geographic borders as well as socioeconomic levels. Currently, it is well known that medical treatment alone is insufficient to ensure adequate and sustainable weight loss and co-morbidity resolution. It has been well proven that bariatric surgery can produce almost immediate resolution of diabetes and other co-morbidities as well as long-term weight loss. OBJECTIVES: Here, we present our experience with the one anastomosis gastric bypass (OAGB) in terms of weight loss and diabetes resolution with 1 year of follow-up...
November 3, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29183269/high-incidence-of-extra-genital-gonorrheal-and-chlamydial-infections-among-high-risk-men-who-have-sex-with-men-and-transgender-women-in-peru
#14
Lao-Tzu Allan-Blitz, Kelika A Konda, Gino M Calvo, Silver K Vargas, Segundo R Leon, Eddy R Segura, Carlos F Caceres, Jeffrey D Klausner
Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are associated with antimicrobial resistance and HIV acquisition. We analyzed data from a cohort of men who have sex with men (MSM) and transgender women followed quarterly for two years in Peru. Incident cases were defined as positive N. gonorrhoeae or C. trachomatis nucleic acid tests during follow-up. Repeat positive tests were defined as reinfection among those with documented treatment. We used generalized estimating equations to calculate adjusted incidence rate ratios (aIRRs)...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29124488/t-helper-1-immune-response-in-metastatic-lymph-nodes-of-pancreatic-ductal-adenocarcinoma-a-marker-for-prolonged-survival
#15
Eran Nizri, Neta Sternbach, Shoshi Bar-David, Amir Ben-Yehuda, Fabian Gerstenhaber, Tali Ofir, Ido Wolf, Gilad Weiner, Guy Lahat, Joseph Klausner
BACKGROUND: Although lymph node (LN) metastases is considered a grave prognostic sign in pancreatic ductal adenocarcinoma (PDAC), patients with positive lymph nodes (PLN) constitute a heterogeneous group. Our purpose was to identify morphological and immune parameters in the primary tumor and in PLN of resected PDAC patients, which could further stratify these patients to different subgroups. METHODS: We retrospectively evaluated histological and immunohistochemical characteristics of 66 patients with PDAC who were operated at our institution...
November 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29097418/prevalence-and-treatment-outcomes-of-routine-chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-testing-during-antenatal-care-gaborone-botswana
#16
Adriane Wynn, Doreen Ramogola-Masire, Ponatshego Gaolebale, Neo Moshashane, Ontiretse Sickboy, Sofia Duque, Elizabeth Williams, Klara Doherty, Jeffrey D Klausner, Chelsea Morroni
OBJECTIVES: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) are curable, mostly asymptomatic, STIs that cause adverse maternal and perinatal outcomes. Most countries do not test for those infections during antenatal care. We implemented a CT, NG and TV testing and treatment programme in an antenatal clinic in Gaborone, Botswana. METHODS: We conducted a prospective study in the antenatal clinic at Princess Marina Hospital in Gaborone, Botswana...
November 2, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29093212/legionella-pneumophila-csra-regulates-a-metabolic-switch-from-amino-acid-to-glycerolipid-metabolism
#17
Ina Häuslein, Tobias Sahr, Pedro Escoll, Nadine Klausner, Wolfgang Eisenreich, Carmen Buchrieser
Legionella pneumophila CsrA plays a crucial role in the life-stage-specific expression of virulence phenotypes and metabolic activity. However, its exact role is only partly known. To elucidate how CsrA impacts L. pneumophila metabolism we analysed the CsrA depended regulation of metabolic functions by comparative (13)C-isotopologue profiling and oxygen consumption experiments of a L. pneumophila wild-type (wt) strain and its isogenic csrA(-) mutant. We show that a csrA(-) mutant has significantly lower respiration rates when serine, alanine, pyruvate, α-ketoglutarate or palmitate is the sole carbon source...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29046409/using-treponemal-assay-signal-strength-cut-off-ratios-to-predict-syphilis-infection
#18
Claire C Bristow, Jeffrey D Klausner
Syphilis screening using the reverse algorithm, a treponemal test for screening followed by a non-treponemal test if reactive, is increasingly being used. This algorithm has several advantages including use of an automated screening test, saving on laboratory time and costs as well as detection of very early syphilis infection. However, under this algorithm, in situations where the treponemal result is positive and the non-treponemal result is non-reactive a second treponemal test must be performed, which may actually lead to inefficiencies in the laboratory...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29043467/do-subjective-alcohol-screening-tools-correlate-with-biomarkers-among-high-risk-transgender-women-and-men-who-have-sex-with-men-in-lima-peru
#19
M C Herrera, K A Konda, S R Leon, B Brown, G M Calvo, H J Salvatierra, C F Caceres, J D Klausner, R Deiss
Alcohol abuse can influence sexual risk behavior; however, its measurement is not straightforward. This study compared self-reported alcohol use, via the AUDIT and CAGE, with levels of phosphatidylethanol (Peth), a phospholipid biomarker that forms with chronic, heavy drinking, among high-risk MSM and TW in Lima, Peru. Chi square, Fisher's exact, Wilcoxon ranksum tests compared the instruments. Receiver operating curves determined sensitivity and specificity of the self-reported measures. Among 69 MSM and 17 TW, PEth was positive for 86% (95% CI 77-93%) of participants, while 67% reported binge-drinking in the last 2 weeks...
November 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29021154/laboratory-validation-of-xpert%C3%A2-ct-ng-and-tv-testing-as-performed-by-nurses-at-three-primary-healthcare-facilities-in-south-africa
#20
Remco P H Peters, Lindsey de Vos, Maduna Liteboho, Maanda Mudau, Jeffrey D Klausner, Marleen M Kock, Andrew Medina-Marino
The introduction of molecular diagnostic tests provides an important step to address the burden of sexually transmitted infections (STIs), especially Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV).….
October 11, 2017: Journal of Clinical Microbiology
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