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https://www.readbyqxmd.com/read/29930157/use-of-geosocial-networking-applications-to-reach-men-who-have-sex-with-men-progress-and-opportunities-for-improvement
#1
EDITORIAL
Jeremy Y Chow, Jeffrey D Klausner
No abstract text is available yet for this article.
June 21, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29904643/prevalidation-of-an-acute-inhalation-toxicity-test-using-the-epiairway-in-vitro-human-airway-model
#2
George R Jackson, Anna G Maione, Mitchell Klausner, Patrick J Hayden
Introduction: Knowledge of acute inhalation toxicity potential is important for establishing safe use of chemicals and consumer products. Inhalation toxicity testing and classification procedures currently accepted within worldwide government regulatory systems rely primarily on tests conducted in animals. The goal of the current work was to develop and prevalidate a nonanimal ( in vitro ) test for determining acute inhalation toxicity using the EpiAirway™ in vitro human airway model as a potential alternative for currently accepted animal tests...
June 1, 2018: Applied in Vitro Toxicology
https://www.readbyqxmd.com/read/29869184/a-systematic-review-of-the-current-status-of-safer-conception-strategies-for-hiv-affected-heterosexual-couples-in-sub-saharan-africa
#3
REVIEW
D Joseph Davey, S West, V Umutoni, S Taleghani, H Klausner, E Farley, R Shah, S Madni, S Orewa, V Kottamasu, V Rice, Z Robbin, K M Wall
We conducted a systematic review of safer conception strategies (SCS) for HIV-affected couples in sub-Saharan Africa to inform evidence-based safer conception interventions. Following PRISMA guidelines, we searched fifteen electronic databases using the following inclusion criteria: SCS research in HIV-affected couples; published after 2007; in sub-Saharan Africa; primary research; peer-reviewed; and addressed a primary topic of interest (SCS availability, feasibility, and acceptability, and/or education and promotion)...
June 4, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29861622/acceptability-and-feasibility-of-integrating-point-of-care-diagnostic-testing-of-sexually-transmitted-infections-into-a-south-african-antenatal-care-program-for-hiv-infected-pregnant-women
#4
E Morikawa, M Mudau, D Olivier, L de Vos, D Joseph Davey, C Price, J A McIntyre, R P Peters, J D Klausner, A Medina-Marino
Background: Chlamydia trachomatis (CT) , Neisseria gonorrhoeae (NG) , and Trichomonas vaginalis (TV) infections may increase the risk of vertical transmission of the human immunodeficiency virus (HIV). In resource-limited settings, symptomatic screening, and syndromic management of sexually transmitted infections (STIs) during pregnancy continue to be the standard of care. In the absence of diagnostic testing, asymptomatic infections in pregnant women go untreated. Objective: To describe the acceptability and feasibility of integrating diagnostic STI screening into first antenatal care visits for HIV-infected pregnant women...
2018: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29777585/potential-vascular-mechanisms-in-an-ex-vivo-functional-pig-bladder-model
#5
Uzoma A Anele, Paul H Ratz, Andrew F Colhoun, Sydney Roberts, Ryan Musselman, Randy A Vince, John E Speich, Adam P Klausner
AIMS: Chronic ischemia is a recognized factor in the pathophysiology of underactive bladder (UAB). Although relative ischemia (ie, low blood flow) is known to occur during filling, little is known regarding the pathophysiology that leads to UAB. Therefore, we developed an ex vivo functional porcine model to investigate the role of transient ischemia and whether autoregulation, a mechanism that maintains tissue oxygenation in certain vital organs, also exists in the bladder. METHODS: Using bladders from slaughtered pigs, we prepared an isolated perfused model where we studied the effects of bladder perfusion flow rate on perfusion pressure and tissue oxygenation during the filling phase...
May 19, 2018: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29766303/comparison-between-laparoscopic-and-open-hartmann-s-reversal-results-of-a-decade-long-multicenter-retrospective-study
#6
Nir Horesh, Yonatan Lessing, Yaron Rudnicki, Ilan Kent, Haguy Kammar, Almog Ben-Yaacov, Yael Dreznik, Shmuel Avital, Eli Mavor, Nir Wasserberg, Hanoch Kashtan, Joseph Klausner, Mordechai Gutman, Oded Zmora, Hagit Tulchinsky
BACKGROUND: Hartmann's reversal is a challenging surgical procedure with significant postoperative morbidity rates. Various surgical methods have been suggested to lower the risk of postoperative complications. In this study, we aimed to compare the postoperative results between open and laparoscopic techniques for Hartmann's reversal. METHODS: A retrospective study of all patients who underwent Hartmann's reversal in five centers in central Israel between January 2004 and June 2015 was conducted...
May 15, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29731331/-advances-in-the-management-of-cervical-lymphadenopathies-of-unknown-primary-with-intensity-modulated-radiotherapy-doses-and-target-volumes
#7
I Troussier, G Klausner, E Blais, P Giraud, L Lahmi, C Pflumio, J-C Faivre, L Geoffrois, E Babin, S Morinière, P Maingon, J Thariat
The definition of nodal and/or mucosal target volumes for radiation therapy for lymphadenopathies of unknown primary is controversial. Target volumes may include all nodal areas bilaterraly and be pan-mucosal or unilateral, selective, including the sole oropharyngeal mucosa. This review presents current recommendations in light of changes in the TNM classification, Human papillomavirus status and therapeutic advances. We conducted a systematic review of the literature with the following keywords: lymphadenopathy; head and neck; unknown primary and radiation therapy...
May 3, 2018: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/29718304/reply-to-kojima-and-klausner
#8
Jean B Nachega, Nadia A Sam-Agudu, Lynne M Mofenson, Mauro Schechter, John W Mellors
No abstract text is available yet for this article.
April 27, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29718167/strategies-to-increase-human-immunodeficiency-virus-testing-among-men-to-reach-unaids-90-90-90-targets
#9
Noah Kojima, Jeffrey D Klausner
No abstract text is available yet for this article.
April 27, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29703706/accelerating-epidemic-control-the-role-of-hiv-self-testing
#10
Noah Kojima, Jeffrey D Klausner
No abstract text is available yet for this article.
June 2018: Lancet HIV
https://www.readbyqxmd.com/read/29665998/lower-urinary-tract-symptoms-including-bladder-outlet-obstruction-what-s-new-in-diagnostics
#11
REVIEW
Stavros Gravas, Iason Kyriazis, Adam P Klausner
It is well known that lower urinary tract symptoms (LUTS) have a multifactorial etiology. Therefore, there is an increased need for improved diagnostics for the optimal assessment of patients with LUTS in order to identify the various causes of symptoms and improve disease phenotyping. Research has focused on the development of improved urodynamic technologies and the development of noninvasive tests that could replace urodynamic studies. This mini-review will present the most recently published studies on the topic including new technologies in the diagnosis of bladder outlet obstruction, novel metrics for bladder sensation, analysis of filling phase rhythm, measurement of detrusor wall tension, and brain imaging during urodynamic studies...
April 14, 2018: European Urology Focus
https://www.readbyqxmd.com/read/29624560/sexual-behaviors-of-hiv-infected-pregnant-women-and-factors-associated-with-sexual-transmitted-infection-in-south-africa
#12
Dvora Joseph Davey, Remco P H Peters, Noah Kojima, Maanda Mudau, Lindsey De Vos, Dawie Olivier, James A McIntyre, Jeffrey D Klausner, Andrew Medina-Marino
BACKGROUND: Sexual behaviors in HIV-infected pregnant women in South Africa are not well understood. METHODS: HIV-infected pregnant women were recruited into a prospective cohort at first antenatal care visit. Sociodemographic information and self-collected vulvovaginal swab samples were collected from participants. Vulvovaginal swab samples were tested for Chlamydia trachomatis (CT), Neisseria gonorrhoea (NG) and Trichomonas vaginalis (TV) using GeneXpert®. We investigated sexual behaviors, alcohol use and factors associated with condomless sex during pregnancy and prevalent sexually transmitted infection (STI) among our cohort...
April 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29596225/use-of-oral-fluid-with-a-rapid-treponemal-test-for-syphilis-evaluation
#13
Claire C Bristow, Chelsea Shannon, Sasha Herbst de Cortina, Jeffrey D Klausner
We aimed to determine if rapid treponemal tests intended for whole blood specimens could be used to detect treponemal antibody in oral fluid. We found a high sensitivity of oral fluid rapid testing, which increased with increasing RPR titer, suggesting potential for the development of accurate rapid oral syphilis tests.
March 29, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29528996/short-report-acceptability-and-feasibility-of-rapid-chlamydial-gonococcal-and-trichomonal-screening-and-treatment-in-pregnant-women-in-six-low-to-middle-income-countries
#14
C L Shannon, C C Bristow, N A Hoff, A Wynn, M Nguyen, A Medina-Marino, J Cabeza, A W Rimoin, J D Klausner
BACKGROUND: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) infections during pregnancy are linked with adverse birth outcomes. However, few countries have prenatal CT, NG, or TV screening programs. In this study, we aimed to evaluate the acceptability and feasibility of CT, NG, and TV screening and treatment among pregnant women across six low-to-middle income countries. METHODS: A total 1,817 pregnant women were screened for CT, NG, and TV in Botswana, the Democratic Republic of Congo (DRC), Haiti, South Africa, and Vietnam...
March 9, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29509566/prevalence-of-mycoplasma-genitalium-and-azithromycin-resistant-infections-among-remnant-clinical-specimens-los-angeles
#15
Lao-Tzu Allan-Blitz, Elisa Mokany, Shelley Miller, Rachel Wee, Chelsea Shannon, Jeffrey D Klausner
BACKGROUND: Mycoplasma genitalium is an important cause of bacterial sexually transmitted diseases. Diagnosis and susceptibility testing of Mycoplasma genitalium are limited by the fastidious nature of the organism. Therefore, the prevalence of infection and azithromycin resistance are poorly studied. METHODS: We conducted an exploratory study on remnant clinical specimens. We collected remnant DNA from urine samples and clinical swabs (cervical/vaginal, rectal, and pharyngeal) previously tested for Neisseria gonorrhoeae and Chlamydia trachomatis using the Cobas 4800 CT/NG assay (Roche Molecular Systems, Pleasanton, CA) between March-April 2017 from across the University of California, Los Angeles Health System...
March 5, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29489420/syphilis-incidence-in-men-who-have-sex-with-men-with-human-immunodeficiency-virus-comorbidity-and-the-importance-of-integrating-sexually-transmitted-infection-prevention-into-hiv-care
#16
Oliver N Refugio, Jeffrey D Klausner
Syphilis continues to be a growing epidemic among men who have sex with men (MSM), particularly for those living with the human immunodeficiency virus (HIV). In 2016, MSM accounted for 80% of primary and secondary syphilis diagnoses in men in the United States; almost half of who were also HIV-infected. The synergistic relationship between HIV and syphilis has significant implications not only for HIV patient management, but also for sexually transmitted infection (STI) control among MSM. Areas covered: We review the literature on STI screening and treatment barriers at the patient-, provider-, and health system-levels, and present strategies to incorporate STI prevention into HIV care settings...
April 2018: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29476278/human-primary-cell-based-organotypic-microtissues-for-modeling-small-intestinal-drug-absorption
#17
Seyoum Ayehunie, Tim Landry, Zachary Stevens, Alex Armento, Patrick Hayden, Mitchell Klausner
PURPOSE: The study evaluates the use of new in vitro primary human cell-based organotypic small intestinal (SMI) microtissues for predicting intestinal drug absorption and drug-drug interaction. METHODS: The SMI microtissues were reconstructed using human intestinal fibroblasts and enterocytes cultured on a permeable support. To evaluate the suitability of the intestinal microtissues to model drug absorption, the permeability coefficients across the microtissues were determined for a panel of 11 benchmark drugs with known human absorption and Caco-2 permeability data...
February 23, 2018: Pharmaceutical Research
https://www.readbyqxmd.com/read/29465686/prevalence-and-detection-of-trichomonas-vaginalis-in-hiv-infected-pregnant-women
#18
Collin M Price, Remco P H Peters, Janré Steyn, Maanda Mudau, Dawie Olivier, Lindsey De Vos, Erika Morikawa, Marleen M Kock, Andrew Medina-Marino, Jeffrey D Klausner
BACKGROUND: Trichomonas vaginalis is a sexually transmitted infection associated with increased transmission of HIV and significant adverse birth outcomes; culture and polymerase chain reaction (PCR) are commonly used in diagnosis. METHODS: Consenting HIV-infected pregnant women were recruited from clinics in South Africa and screened for T. vaginalis using PCR. Polymerase chain reaction-positive women provided an additional sample for culture. We compared T. vaginalis detection between PCR and culture, and investigated how PCR cycle threshold (Ct) values differ among culture results...
May 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465685/ciprofloxacin-may-be-efficacious-in-treating-wild-type-gyrase-a-genotype-neisseria-gonorrhoeae-infections
#19
Lao-Tzu Allan-Blitz, Peera Hemarajata, Romney M Humphries, Mabel Kimble, Sam Elias, Jeffrey D Klausner
No abstract text is available yet for this article.
April 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29371068/treating-chlamydial-infections-in-pregnancy-and-preventing-adverse-birth-outcomes
#20
Paul C Adamson, Jeffrey D Klausner
No abstract text is available yet for this article.
April 2018: Lancet Infectious Diseases
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