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https://www.readbyqxmd.com/read/29021154/laboratory-validation-of-xpert%C3%A2-ct-ng-and-tv-testing-as-performed-by-nurses-at-three-primary-healthcare-facilities-in-south-africa
#1
Remco P H Peters, Lindsey de Vos, Maduna Liteboho, Maanda Mudau, Jeffrey D Klausner, Marleen M Kock, Andrew Medina-Marino
The introduction of molecular diagnostic tests provides an important step to address the burden of sexually transmitted infections (STIs), especially Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV).….
October 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28984579/follow-up-of-patients-undergoing-oncoplastic-surgery-more-palpable-masses-and-benign-biopsies
#2
Yoav Amitai, Orit Golan, Yoav Barnea, Joseph Klausner, Tehillah S Menes
BACKGROUND: Oncoplastic reconstruction is increasingly used in the management of women undergoing breast conserving surgery. We examined the findings on breast exam and imaging of patients who underwent breast conservation with or without oncoplastic reconstruction. OBJECTIVE: We hypothesized that patients undergoing immediate breast reconstruction would present with more palpable and imaging abnormalities compared to lumpectomy alone and undergo therefore more biopsies...
October 3, 2017: Breast Disease
https://www.readbyqxmd.com/read/28930022/diagnosis-of-fatal-human-case-of-st-louis-encephalitis-virus-infection-by-metagenomic-sequencing-california-2016
#3
Charles Y Chiu, Lark L Coffey, Jamie Murkey, Kelly Symmes, Hannah A Sample, Michael R Wilson, Samia N Naccache, Shaun Arevalo, Sneha Somasekar, Scot Federman, Doug Stryke, Paul Vespa, Gary Schiller, Sharon Messenger, Romney Humphries, Steve Miller, Jeffrey D Klausner
We used unbiased metagenomic next-generation sequencing to diagnose a fatal case of meningoencephalitis caused by St. Louis encephalitis virus in a patient from California in September 2016. This case is associated with the recent 2015-2016 reemergence of this virus in the southwestern United States.
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28891022/converting-a-sleeve-gastrectomy-to-a-gastric-bypass-for-weight-loss-failure-is-it-worth-it
#4
Nadav Nevo, Subhi Abu-Abeid, Guy Lahat, Joseph Klausner, Shai M Eldar
BACKGROUND: Sleeve gastrectomy (SG) is gaining popularity and has become the procedure of choice for many bariatric surgeons. Long-term weight loss failure is not uncommon. The preferred revisional procedure for these patients is still under debate. OBJECTIVE: The objective of this study was to assess the safety and efficacy of laparoscopic gastric bypass as a revisional surgery for sleeve gastrectomy patients with weight loss failure. SETTING: The study was done at a bariatric surgery center in a university hospital...
September 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28879552/considerations-for-hartmann-s-reversal-and-hartmann-s-reversal-outcomes-a-multicenter-study
#5
Nir Horesh, Yonatan Lessing, Yaron Rudnicki, Ilan Kent, Haguy Kammar, Almog Ben-Yaacov, Yael Dreznik, Hagit Tulchinsky, Shmuel Avital, Eli Mavor, Nir Wasserberg, Hanoch Kashtan, Joseph M Klausner, Mordechai Gutman, Oded Zmora
PURPOSE: Hartmann's procedure is commonly practiced in emergent cases with the restoration of bowel continuity planned at a second stage. This study assessed the rate of restorations following Hartmann's procedure and evaluated factors affecting decision-making. METHODS: Data on patient demographics, comorbidities, causes for Hartmann's procedure, reversal rate, and complications were collected in a multicenter retrospective cohort study of patients who underwent Hartmann's procedure in five medical centers...
September 6, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28876326/keep-screening-maternal-gonococcal-infection-and-adverse-birth-outcomes
#6
Chelsea Lee Shannon, Jeffrey D Klausner
No abstract text is available yet for this article.
April 28, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28866636/transient-aortitis-documented-by-positron-emission-tomography-in-a-case-series-of-men-and-transgender-women-infected-with-syphilis
#7
Dvora Joseph Davey, Noah Kojima, Kelika A Konda, Pawan Gupta, Segundo R Leon, Gino M Calvo, Carlos F Caceres, Jeffrey D Klausner
OBJECTIVES: Syphilis infection persists globally contributing to preventable and treatable morbidity and mortality. How extensive early syphilis disseminates is unknown. To better understand the relationship between early syphilis infection and inflammation over time, our study enrolled six individuals recently infected with syphilis for sequential positron emission tomography (PET) scans. METHODS: We evaluated a case series of six individuals with high syphilis titres (two secondary, two early latent and two latent, unknown duration, but with high titre) who received sequential PET scans to assess inflammation over time and its response to treatment...
September 2, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28846743/evaluation-of-two-4th-generation-point-of-care-assays-for-the-detection-of-human-immunodeficiency-virus-infection
#8
Chrysovalantis Stafylis, Jeffrey D Klausner
BACKGROUND: Fourth generation assays detect simultaneously antibodies for HIV and the p24 antigen, identifying HIV infection earlier than previous generation tests. Previous studies have shown that the Alere Determine HIV-1/2 Combo has lower than anticipated performance in detecting antibodies for HIV and the p24 antigen. Furthermore, there are currently very few studies evaluating the performance of Standard Diagnostics BIOLINE HIV Ag/Ab Combo. OBJECTIVE: To evaluate the performance of the Alere Determine HIV-1/2 Combo and the Standard Diagnostics BIOLINE HIV Ag/Ab Combo in a panel of frozen serum samples...
2017: PloS One
https://www.readbyqxmd.com/read/28843985/laparoscopic-sleeve-gastrectomy-for-diabetics-5-year-outcomes
#9
Yonatan Lessing, Niv Pencovich, Guy Lahat, Joseph M Klausner, Subhi Abu-Abeid, Shai Meron Eldar
OBJECTIVE: Although the laparoscopic sleeve gastrectomy (SG) is increasingly performed for morbid obesity, gastric bypass is still considered by many to be the gold standard procedure for obese diabetic patients. The aim of this study was to assess the long-term results of SG in morbidly obese patients with type 2 diabetes. METHODS: Diabetic patients who underwent SG at a single center between 2009 and 2011 were included. Outcomes assessed included postoperative complications, weight loss, and resolution or improvement in co-morbidities with an emphasis on diabetes, including glycated hemoglobin (HbA1C) and medication status...
July 18, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28842209/longitudinal-gender-disparity-in-female-urology-resident-primary-authorship-at-an-american-urological-association-sectional-meeting
#10
Tony R Lin, Neil J Kocher, Adam P Klausner, Jay D Raman
OBJECTIVE: To further evaluate the academic representation of female urology residents in the United States, we reviewed abstracts from the Mid-Atlantic American Urological Association (MA-AUA) sectional meetings to determine if the recent increase in the number of female urology residents mirrored an increase in this group's abstract authorship. METHODS: Full text abstracts from the MA-AUA meetings were analyzed from 2008-2014 excluding one joint section meeting...
August 22, 2017: Urology
https://www.readbyqxmd.com/read/28835340/quantification-of-bladder-wall-biomechanics-during-urodynamics-a-methodologic-investigation-using-ultrasound
#11
Anna S Nagle, Adam P Klausner, Jary Varghese, Rachel J Bernardo, Andrew F Colhoun, Robert W Barbee, Laura R Carucci, John E Speich
Overactive bladder is often characterized by biomechanical changes in the bladder wall, but there is no established method to measure these changes in vivo. The goal of this study was to develop a novel method to determine detrusor wall biomechanical parameters during urodynamics through the incorporation of transabdominal ultrasound imaging. Individuals with overactive bladder (OAB) underwent ultrasound imaging during filling. The fill rate was 10% of the cystometric capacity per minute as determined by an initial fill...
August 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28820375/epidemiology-of-neisseria-gonorrhoeae-gyrase-a-genotype-los-angeles-california-usa
#12
Ashima A Bhatti, Lao-Tzu Allan-Blitz, Mariana Castrejon, Romney M Humphries, Peera Hemarajata, Jeffrey D Klausner
We investigated the epidemiology of the mutant gyrase A gene, a reliable predictor of ciprofloxacin resistance, in Neisseria gonorrhoeae infections at UCLA Health in Los Angeles, California, USA, during November 1, 2015-August 31, 2016. Among 110 patients with N. gonorrhoeae infections, 48 (44%) had the mutant gyrase A gene.
September 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28799824/high-prevalence-of-asymptomatic-sexually-transmitted-infections-among-human-immunodeficiency-virus-infected-pregnant-women-in-a-low-income-south-african-community
#13
Maanda Mudau, Remco P Peters, Lindsey De Vos, Dawie H Olivier, Dvora J Davey, Edwin S Mkwanazi, James A McIntyre, Jeffrey D Klausner, Andrew Medina-Marino
There is a lack of evidence on the burden of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) among HIV-infected pregnant women in South Africa. We conducted a cross-sectional analysis of HIV-infected pregnant women in two healthcare facilities in a South African township to determine the prevalence of CT, NG and TV. HIV-infected pregnant women were recruited during the first antenatal care visit for their current pregnancy and requested to self-collect vulvovaginal swab specimens...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28752101/implementation-of-a-large-system-wide-hepatitis-c-virus-screening-and-linkage-to-care-program-for-baby-boomers
#14
Mariana Castrejón, Kara W Chew, Marjan Javanbakht, Romney Humphries, Sammy Saab, Jeffrey D Klausner
BACKGROUND: We implemented and evaluated a large health system-wide hepatitis C virus (HCV) screening and linkage to care program for persons born between 1945 and 1965 ("baby boomers"). METHODS: An electronic health record (EHR) clinical decision support (CDS) tool for HCV screening for baby boomers was introduced in August 2015 for patients seen in the outpatient University of California, Los Angeles healthcare system setting. An HCV care coordinator was introduced in January 2016 to facilitate linkage to HCV care...
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28745836/effects-of-vesical-and-perfusion-pressure-on-perfusate-flow-and-flow-on-vesical-pressure-in-the-isolated-perfused-working-pig-bladder-reveal-a-potential-mechanism-for-the-regulation-of-detrusor-compliance
#15
Randy Vince, Andrew Tracey, Nicholas A Deebel, Robert W Barbee, John E Speich, Adam P Klausner, Paul H Ratz
AIMS: Although there is evidence that deficits in bladder blood flow negatively impact bladder function, the effects of vesical, and perfusion pressures on bladder perfusion (perfusate flow), and of perfusate flow on vesical pressure, remain poorly understood. The present study used the isolated perfused working pig bladder model to examine the relationships between blood flow, and vesical and perfusion pressures. METHODS: Vesical arteries of pig bladders obtained from a local slaughterhouse were cannulated and perfused with Krebs-Henseleit solution at different pressures, and with carbachol to cause bladder contraction...
July 26, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28721353/hepatitis-e-virus-associated-meningoencephalitis-in-a-lung-transplant-recipient-diagnosed-by-clinical-metagenomic-sequencing
#16
Jamie A Murkey, Kara W Chew, Margrit Carlson, Chelsea L Shannon, Deepika Sirohi, Hannah A Sample, Michael R Wilson, Paul Vespa, Romney M Humphries, Steve Miller, Jeffrey D Klausner, Charles Y Chiu
Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.
2017: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28716771/an-intervention-using-gamification-to-increase-human-immunodeficiency-virus-and-sexually-transmitted-infection-screening-among-young-men-who-have-sex-with-men-in-california-rationale-and-design-of-stick-to-it
#17
Christopher M Mejia, Daniel Acland, Raluca Buzdugan, Reva Grimball, Lauren Natoli, Mark R McGrath, Jeffrey D Klausner, Sandra I McCoy
BACKGROUND: In the United States, young men who have sex with men (YMSM) remain disproportionately affected by human immunodeficiency virus (HIV) and other sexually transmitted infections (STIs). Although routine HIV/STI screening is pivotal to the timely diagnosis of HIV and STIs, initiation of appropriate treatment, and reduced onward disease transmission, repeat screening is underused. Novel interventions that incorporate elements of games, an approach known as gamification, have the potential to increase routinization of HIV/STI screening among YMSM...
July 17, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28716318/surveillance-strategies-for-neurogenic-lower-urinary-tract-dysfunction
#18
REVIEW
Randy A Vince, Adam P Klausner
Patients with neurogenic lower urinary tract dysfunction (NLUTD) experience significant morbidity and mortality due to urological complications including upper tract damage and bladder malignancy. This has led to increased surveillance in patients NLUTD. This article discusses the methods available for surveillance of patients with NLUTD and pulls information from the largest and most established organizations that have produced evidence-based surveillance guidelines for NLUTD. These organizations include the Paralyzed Veterans of America (PVA), US Department of Veterans Affairs, European Association of Urology (EAU), The NICE organization from the UK, and cites additional literature not been included in these documents...
August 2017: Urologic Clinics of North America
https://www.readbyqxmd.com/read/28701271/health-systems-and-the-new-strategy-against-sexually-transmitted-infections
#19
Jeffrey D Klausner, Nathalie Broutet
No abstract text is available yet for this article.
July 7, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28684611/rapid-and-point-of-care-tests-for-the-diagnosis-of-trichomonas-vaginalis-in-women-and-men
#20
Charlotte A Gaydos, Jeffrey D Klausner, Nitika Pant Pai, Helen Kelly, Cordelia Coltart, Rosanna W Peeling
BACKGROUND: Trichomonasvaginalis (TV) is a highly prevalent parasitic infection worldwide. It is associated with many adverse reproductive health outcomes. Many infections are asymptomatic and syndromic management leads to underdetection of TV. Traditional methods of TV detection such as wet preparation are insensitive. New rapid, point-of-care (POC) tests can enhance the diagnosis of trichomoniasis. METHODS: The authors reviewed the literature and discuss older POC tests for TV detection, as well as the OSOM lateral flow test, the AmpliVue test, the Solana test and the GeneXpert test as well as the limitations of wet preparation and culture for detection of TV...
July 6, 2017: Sexually Transmitted Infections
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