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https://www.readbyqxmd.com/read/28326356/effect-of-four-monthly-doses-of-a-human-monoclonal-anti-fgf23-antibody-krn23-on-quality-of-life-in-x-linked-hypophosphatemia
#1
Mary D Ruppe, Xiaoping Zhang, Erik A Imel, Thomas J Weber, Mark A Klausner, Takahiro Ito, Maria Vergeire, Jeffrey S Humphrey, Francis H Glorieux, Anthony A Portale, Karl Insogna, Munro Peacock, Thomas O Carpenter
X-linked hypophosphatemia (XLH) is characterized by lower extremity deformities that lead to bone and/or joint pain that result from decreased renal tubular reabsorption leading to hypophosphatemia caused by elevated levels of fibroblast growth factor 23 (FGF23). OBJECTIVE: Validate the use of SF-36v2 Health Survey (SF-36v2) and the Western Ontario and McMaster Osteoarthritis Index (WOMAC) to measure previously unstudied health-related quality of life (HRQoL) in XLH patients and determine the change in HRQoL before and after treatment with KRN23, a human monoclonal anti-FGF23 antibody...
December 2016: Bone Reports
https://www.readbyqxmd.com/read/28282646/point-of-care-sexually-transmitted-infection-diagnostics-proceedings-of-the-star-sexually-transmitted-infection-clinical-trial-group-programmatic-meeting
#2
Anthony D Cristillo, Claire C Bristow, Rosanna Peeling, Barbara Van Der Pol, Sasha Herbst de Cortina, Ivan K Dimov, Nitika Pant Pai, Dong Jin Shin, Ricky Y T Chiu, Catherine Klapperich, Purnima Madhivanan, Sheldon R Morris, Jeffrey D Klausner
The goal of the point-of-care (POC) sexually transmitted infection (STI) Diagnostics meeting was to review the state-of-the-art research and develop recommendations for the use of POC STI diagnostics. Experts from academia, government, nonprofit, and industry discussed POC diagnostics for STIs such as Chlamydia trachomatis, human papillomavirus, Neisseria gonorrhoeae, Trichomonas vaginalis, and Treponema pallidum. Key objectives included a review of current and emerging technologies, clinical and public health benefits, POC STI diagnostics in developing countries, regulatory considerations, and future areas of development...
April 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28264668/implementing-and-sustaining-a-mobile-medical-clinic-for-prenatal-care-and-sexually-transmitted-infection-prevention-in-rural-mysore-india
#3
Noah Kojima, Karl Krupp, Kavitha Ravi, Savitha Gowda, Poornima Jaykrishna, Caitlyn Leonardson-Placek, Anand Siddhaiah, Claire C Bristow, Anjali Arun, Jeffrey D Klausner, Purnima Madhivanan
BACKGROUND: In rural India, mobile medical clinics are useful models for delivering health promotion, education, and care. Mobile medical clinics use fewer providers for larger catchment areas compared to traditional clinic models in resource limited settings, which is especially useful in areas with shortages of healthcare providers and a wide geographical distribution of patients. METHODS: From 2008 to 2011, we built infrastructure to implement a mobile clinic system to educate rural communities about maternal child health, train community health workers in common safe birthing procedures, and provide comprehensive antenatal care, prevention of mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV), and testing for specific infections in a large rural catchment area of pregnant women in rural Mysore...
March 6, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28263140/reply-by-authors-re-canadian-pediatrics-society-position-statement-on-newborn-circumcision-a-risk-benefit-analysis-revisited
#4
Brian J Morris, Jeffrey D Klausner, John N Krieger, Bradley J Willcox, Pierre D Crouse, Neil Pollock
EDITORIAL.
February 2017: Canadian Journal of Urology
https://www.readbyqxmd.com/read/28250095/evaluation-of-a-screening-program-to-detect-critical-congenital-heart-defects-in-newborns
#5
Rachel Klausner, Eugene D Shapiro, Robert W Elder, Eve Colson, Jaspreet Loyal
OBJECTIVES: To report the results of and to identify problems with implementing a screening program to detect critical congenital heart defects (CCHDs) in newborns by using differential pulse oximetry (POx). METHODS: Charts of all live-born infants from 4 Yale-New Haven health system hospitals in Connecticut between January 1 and December 31, 2014, were reviewed. RESULTS: Of 10 589 newborns, 171 (1.6%) underwent an echocardiogram before screening, 10 320 (97...
March 1, 2017: Hospital Pediatrics
https://www.readbyqxmd.com/read/28238521/solid-pseudopapillary-neoplasm-of-the-pancreas-management-and-long-term-outcome
#6
N Lubezky, M Papoulas, Y Lessing, G Gitstein, E Brazowski, I Nachmany, G Lahat, Y Goykhman, A Ben-Yehuda, R Nakache, J M Klausner
BACKGROUND: Solid pseudopapillary neoplasm (SPN) of pancreas is a rare pancreatic neoplasm with a low metastatic potential. Our aim was to study the clinical-pathological characteristics, and long-term outcome of this tumor. MATERIALS: Rretrospective single center study of patients operated for SPN of pancreas. Clinical and pathological data were collected. RESULTS: From 1995 to 2016, 1320 patients underwent pancreatic resection. SPN was confirmed in 32 cases (2...
February 10, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28225453/addressing-concerns-regarding-preexposure-prophylaxis-meta-analysis
#7
Noah Kojima, Dvora Joseph Davey, Jeffrey D Klausner
No abstract text is available yet for this article.
March 13, 2017: AIDS
https://www.readbyqxmd.com/read/28187279/next-generation-sequencing-of-circulating-tumor-dna-for-early-cancer-detection
#8
Alexander M Aravanis, Mark Lee, Richard D Klausner
Curative therapies are most successful when cancer is diagnosed and treated at an early stage. We advocate that technological advances in next-generation sequencing of circulating, tumor-derived nucleic acids hold promise for addressing the challenge of developing safe and effective cancer screening tests.
February 9, 2017: Cell
https://www.readbyqxmd.com/read/28185723/hiv-testing-preferences-among-msm-members-of-an-lgbt-community-organization-in-los-angeles
#9
Alexandra Medline, Joseph Daniels, Robert Marlin, Sean Young, Greg Wilson, Emily Huang, Jeffrey D Klausner
Lack of regular HIV testing puts African American, Asian, and Latino men who have sex with men (MSM) at high risk for HIV infection. Rapid self-testing may be an effective option for these men. We explored acceptability, preferences, and usability of HIV self-test kits with MSM of color using semi-structured focus groups to discuss HIV testing history, reasons for testing, and self-testing preferences. Participants (n = 21) lived in Los Angeles, identified as MSM of color, and were 18-35 years of age. Discussions were audio-recorded, transcribed, and analyzed using grounded theory...
January 12, 2017: Journal of the Association of Nurses in AIDS Care: JANAC
https://www.readbyqxmd.com/read/28185313/improvement-in-lower-urinary-tract-symptoms-across-multiple-domains-following-ventriculoperitoneal-shunting-for-idiopathic-normal-pressure-hydrocephalus
#10
Sarah C Krzastek, Samuel P Robinson, Harold F Young, Adam P Klausner
AIMS: The purpose of this study was to evaluate the change in lower urinary tract symptoms following ventriculoperitoneal shunting in patients with idiopathic normal pressure hydrocephalus (iNPH). METHODS: Lower urinary tract symptoms in patients with new-onset iNPH were prospectively evaluated using validated questionnaires from the International Consultation on Incontinence to assess overactive bladder (ICIq-OAB), incontinence (ICIq-UI), and quality of life (ICIq-LUTqol), as well as the American Urological Association Symptom Score bother scale, prior to and following ventriculoperitoneal shunting for iNPH...
February 10, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28178111/demographics-behaviors-and-sexual-health-characteristics-of-high-risk-men-who-have-sex-with-men-and-transgender-women-who-use-social-media-to-meet-sex-partners-in-lima-peru
#11
Jeremy Y Chow, Kelika A Konda, Gino M Calvo, Jeffrey D Klausner, Carlos F Cáceres
BACKGROUND: Men who have sex with men (MSM) and transgender women (TW) in Peru bear a disproportionate burden of human immunodeficiency virus (HIV) and sexually transmitted infections (STIs). In a context of quickly expanding communication technology, increasing numbers of MSM and TW are using social media applications to seek sex partners. Understanding social media users and their sex partnering practices is needed to update HIV and STI prevention programming. METHODS: In Lima, Peru, 312 MSM and 89 TW from 2 STI clinics underwent HIV and STI testing and participated in a survey of demographics, behaviors, sexual health, and social media practices...
March 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28166698/partner-notification-and-treatment-for-sexually-transmitted-infections-among-pregnant-women-in-gaborone-botswana
#12
Ogechukwu A Offorjebe, Adriane Wynn, Neo Moshashane, Dvora Joseph Davey, Kaitlin Arena, Doreen Ramogola-Masire, Ponatshego Gaolebale, Chelsea Morroni, Jeffrey D Klausner
Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) are sexually transmitted infections (STIs) associated with adverse birth outcomes. Untreated partners contribute to high rates of STI reinfection; thus, partner notification and treatment remain important components of STI care and control. A prospective cohort study was conducted among 300 pregnant women presenting to the antenatal clinic at Princess Marina Hospital in Gaborone, Botswana who enrolled in an STI screening study...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28152672/intraoperative-localization-of-rectal-tumors-using-liposomal-indocyanine-green
#13
Shlomo Magdassi, Shoshi Bar-David, Yael Friedman-Levi, Ehud Zigmond, Chen Varol, Guy Lahat, Joseph Klausner, Sara Eyal, Eran Nizri
BACKGROUND: Tumor localization may pose a significant challenge during minimally invasive rectal resection. Near-infrared (NIR) imaging can penetrate biological tissue and afford tumor localization from the external surface of the rectum. Our aim was to develop an NIR-based tool for rectal tumor imaging that can be administered intravenously. METHODS: We prepared indocyanine-green (ICG)-loaded liposomes by sonication. Liposomes were evaluated for their size and morphology...
February 1, 2017: Surgical Innovation
https://www.readbyqxmd.com/read/28134005/chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-screening-and-treatment-of-pregnant-women-in-port-au-prince-haiti
#14
Claire C Bristow, Patricia Mathelier, Oksana Ocheretina, Daphne Benoit, Jean W Pape, Adriane Wynn, Jeffrey D Klausner
In Haiti, routine screening for Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) among pregnant women is not conducted; yet these sexually transmitted infections (STIs) are associated with adverse birth and newborn health outcomes. We aimed to assess the acceptability and feasibility of screening and the prevalence of STIs among pregnant women in Port-au-Prince, Haiti. Pregnant women of at least 18 years of age who attend Haitian Study Group for Kaposi's sarcoma and Opportunistic Infections (GHESKIO) clinics in Port-au-Prince, Haiti provided self-collected vaginal swab specimens...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/28034887/implementation-of-a-rapid-genotypic-assay-to-promote-targeted-ciprofloxacin-therapy-of-neisseria-gonorrhoeae-in-a-large-health-system
#15
Lao-Tzu Allan-Blitz, Romney M Humphries, Peera Hemarajata, Ashima Bhatti, Mark W Pandori, Mark J Siedner, Jeffrey D Klausner
Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.
December 28, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28027817/management-of-endoscopic%C3%A2-retrograde-cholangiopancreatography-related-perforations-experience-of-a-tertiary-center
#16
Roi Weiser, Niv Pencovich, Liat Mlynarsky, Adi Berliner-Senderey, Guy Lahat, Erwin Santo, Joseph M Klausner, Ido Nachmany
BACKGROUND: Endoscopic retrograde cholangiopancreatography-induced perforation (EP) is a rare but severe complication. We describe the risk factors, management, and outcome of ERCP-induced perforations in a tertiary center. METHODS: This is a case-control study. All EP cases between March 2004 and February 2015 were compared to a control group without perforation. Data on patients, procedures, presentation, perforation type, radiologic findings, management, and outcome were assessed...
December 24, 2016: Surgery
https://www.readbyqxmd.com/read/28025660/low-amplitude-rhythmic-contraction-frequency-in-human-detrusor-strips-correlates-with-phasic-intravesical-pressure-waves
#17
Andrew F Colhoun, John E Speich, Lauren F Cooley, Eugene D Bell, R Wayne Barbee, Georgi Guruli, Paul H Ratz, Adam P Klausner
PURPOSE: Low amplitude rhythmic contractions (LARC) occur in detrusor smooth muscle and may play a role in storage disorders such as overactive bladder and detrusor overactivity. The purpose of this study was to determine whether LARC frequencies identified in vitro from strips of human urinary bladder tissue correlate with in vivo LARC frequencies, visualized as phasic intravesical pressure (p ves) waves during urodynamics (UD). METHODS: After IRB approval, fresh strips of human urinary bladder were obtained from patients...
December 26, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27927867/mastermind-bringing-microbial-diagnostics-to-the-clinic
#18
Robin Patel, Ephraim L Tsalik, Elizabeth Petzold, Vance G Fowler, Jeffrey D Klausner, Scott Evans
New diagnostics are urgently needed to address emerging antimicrobial resistance. The Antibacterial Resistance Leadership Group proposes a strategy called MASTERMIND (Master Protocol for Evaluating Multiple Infection Diagnostics) for advancement of infectious diseases diagnostics. The goal of this strategy is to generate the data necessary to support US Food and Drug Administration clearance of new diagnostic tests by promoting research that might not have otherwise been feasible with conventional trial designs...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27905998/sexually-transmitted-infections-and-pre-exposure-prophylaxis-challenges-and-opportunities-among-men-who-have-sex-with-men-in-the-us
#19
REVIEW
Hyman M Scott, Jeffrey D Klausner
Pre-Exposure Prophylaxis (PrEP) has shown high efficacy in preventing human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) in several large clinical trials, and more recently in "real world" reports of clinical implementation and a PrEP demonstration project. Those studies also demonstrated high bacterial sexually transmitted infection (STI) incidence and raised the discussion of how PrEP may impact STI control efforts, especially in the setting of increasing Neisseria gonorrhoeae antimicrobial resistance and the increase in syphilis cases among MSM...
January 19, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905934/estimation-of-country-specific-and-global-prevalence-of-male-circumcision
#20
Brian J Morris, Richard G Wamai, Esther B Henebeng, Aaron Ar Tobian, Jeffrey D Klausner, Joya Banerjee, Catherine A Hankins
BACKGROUND: Male circumcision (MC) status and genital infection risk are interlinked and MC is now part of HIV prevention programs worldwide. Current MC prevalence is not known for all countries globally. Our aim was to provide estimates for country-specific and global MC prevalence. METHODS: MC prevalence data were obtained by searches in PubMed, Demographic and Health Surveys, AIDS Indicator Surveys, and Behavioural Surveillance Surveys. Male age was ≥15 years in most surveys...
March 1, 2016: Population Health Metrics
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