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https://www.readbyqxmd.com/read/28034887/implementation-of-a-rapid-genotypic-assay-to-promote-targeted-ciprofloxacin-therapy-of-neisseria-gonorrhoeae-in-a-large-health-system
#1
Lao-Tzu Allan-Blitz, Romney M Humphries, Peera Hemarajata, Ashima Bhatti, Mark W Pandori, Mark J Siedner, Jeffrey D Klausner
Multidrug-resistant Neisseria gonorrhoeae is a top threat to public health. In November 2015, UCLA Health introduced a rapid gyrase A (gyrA) genotypic assay for prediction of Neisseria gonorrhoeae susceptibility to ciprofloxacin. We found a significant reduction in ceftriaxone use with a concomitant increase in targeted therapy.
December 28, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28027817/management-of-endoscopic%C3%A2-retrograde-cholangiopancreatography-related-perforations-experience-of-a-tertiary-center
#2
Roi Weiser, Niv Pencovich, Liat Mlynarsky, Adi Berliner-Senderey, Guy Lahat, Erwin Santo, Joseph M Klausner, Ido Nachmany
BACKGROUND: Endoscopic retrograde cholangiopancreatography-induced perforation (EP) is a rare but severe complication. We describe the risk factors, management, and outcome of ERCP-induced perforations in a tertiary center. METHODS: This is a case-control study. All EP cases between March 2004 and February 2015 were compared to a control group without perforation. Data on patients, procedures, presentation, perforation type, radiologic findings, management, and outcome were assessed...
December 24, 2016: Surgery
https://www.readbyqxmd.com/read/28025660/low-amplitude-rhythmic-contraction-frequency-in-human-detrusor-strips-correlates-with-phasic-intravesical-pressure-waves
#3
Andrew F Colhoun, John E Speich, Lauren F Cooley, Eugene D Bell, R Wayne Barbee, Georgi Guruli, Paul H Ratz, Adam P Klausner
PURPOSE: Low amplitude rhythmic contractions (LARC) occur in detrusor smooth muscle and may play a role in storage disorders such as overactive bladder and detrusor overactivity. The purpose of this study was to determine whether LARC frequencies identified in vitro from strips of human urinary bladder tissue correlate with in vivo LARC frequencies, visualized as phasic intravesical pressure (p ves) waves during urodynamics (UD). METHODS: After IRB approval, fresh strips of human urinary bladder were obtained from patients...
December 26, 2016: World Journal of Urology
https://www.readbyqxmd.com/read/27927867/mastermind-bringing-microbial-diagnostics-to-the-clinic
#4
Robin Patel, Ephraim L Tsalik, Elizabeth Petzold, Vance G Fowler, Jeffrey D Klausner, Scott Evans
New diagnostics are urgently needed to address emerging antimicrobial resistance. The Antibacterial Resistance Leadership Group proposes a strategy called MASTERMIND (Master Protocol for Evaluating Multiple Infection Diagnostics) for advancement of infectious diseases diagnostics. The goal of this strategy is to generate the data necessary to support US Food and Drug Administration clearance of new diagnostic tests by promoting research that might not have otherwise been feasible with conventional trial designs...
December 7, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27905998/sexually-transmitted-infections-and-pre-exposure-prophylaxis-challenges-and-opportunities-among-men-who-have-sex-with-men-in-the-us
#5
REVIEW
Hyman M Scott, Jeffrey D Klausner
Pre-Exposure Prophylaxis (PrEP) has shown high efficacy in preventing human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) in several large clinical trials, and more recently in "real world" reports of clinical implementation and a PrEP demonstration project. Those studies also demonstrated high bacterial sexually transmitted infection (STI) incidence and raised the discussion of how PrEP may impact STI control efforts, especially in the setting of increasing Neisseria gonorrhoeae antimicrobial resistance and the increase in syphilis cases among MSM...
January 19, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27905934/estimation-of-country-specific-and-global-prevalence-of-male-circumcision
#6
Brian J Morris, Richard G Wamai, Esther B Henebeng, Aaron Ar Tobian, Jeffrey D Klausner, Joya Banerjee, Catherine A Hankins
BACKGROUND: Male circumcision (MC) status and genital infection risk are interlinked and MC is now part of HIV prevention programs worldwide. Current MC prevalence is not known for all countries globally. Our aim was to provide estimates for country-specific and global MC prevalence. METHODS: MC prevalence data were obtained by searches in PubMed, Demographic and Health Surveys, AIDS Indicator Surveys, and Behavioural Surveillance Surveys. Male age was ≥15 years in most surveys...
March 1, 2016: Population Health Metrics
https://www.readbyqxmd.com/read/27885536/safety-and-outcome-of-laparoscopic-sleeve-gastrectomy-following-removal-of-adjustable-gastric-banding-lessons-from-109-patients-in-a-single-center-and-review-of-the-literature
#7
Niv Pencovich, Guy Lahat, Orit Goldray, Subhi Abu-Abeid, Joseph M Klausner, Shai Meron Eldar
BACKGROUND: Although considered a common bariatric procedure, laparoscopic adjustable gastric banding (LAGB) is associated with high rates of weight loss failure and long-term complications. PURPOSE: The purpose of this study was to re-assess the safety and outcome of conversion of failed LAGB to laparoscopic sleeve gastrectomy (LSG). MATERIALS AND METHODS: One hundred and nine patients underwent conversion from LAGB to LSG (78 females, mean age 43 ± 11...
November 24, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27861243/differences-in-risk-behavior-and-demographic-factors-between-men-who-have-sex-with-men-with-acute-and-non-acute-human-immunodeficiency-virus-infection-in-a-community-based-testing-program-in-los-angeles
#8
Dvora Joseph Davey, Matthew Beymer, Chelsea P Roberts, Robert K Bolan, Jeffrey D Klausner
INTRODUCTION: High viremia combined with HIV-infection status unawareness and increased sexual risk behavior contributes to a disproportionate amount of new HIV infections. METHODS: From August 2011-July 2015, the Los Angeles LGBT Center conducted 66,546 HIV tests. We compared factors including the presence of concomitant sexually transmitted infections, number of recent sex partners and reported condomless anal intercourse between men who have sex with men (MSM) diagnosed with an acute HIV infection and a non-acute HIV infection using multivariable logistic regression...
November 15, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/27828856/analysis-of-histological-and-immunological-parameters-of-metastatic-lymph-nodes-from-colon-cancer-patients-reveals-that-t-helper-1-type-immune-response-is-associated-with-improved-overall-survival
#9
Eran Nizri, Nofar Greenman-Maaravi, Shoshi Bar-David, Amir Ben-Yehuda, Gilad Weiner, Guy Lahat, Joseph Klausner
Lymph node (LN) involvement in colonic carcinoma (CC) is a grave prognostic sign and mandates the addition of adjuvant treatment. However, in light of the histological variability and outcomes observed, we hypothesized that patients with LN metastases (LNM) comprise different subgroups.We retrospectively analyzed the histological sections of 82 patients with CC and LNM. We studied various histological parameters (such as tumor grade, desmoplasia, and preservation of LN architecture) as well as the prevalence of specific peritumoral immune cells (CD8, CD20, T-bet, and GATA-3)...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27782906/trabectedin-in-advanced-desmoplastic-round-cell-tumors-a-retrospective-single-center-series
#10
Benjamin Verret, Charles Honore, Sarah Dumont, Philippe Terrier, Julien Adam, Andrea Cavalcanti, Isabelle Sourrouille, Guillaume Klausner, Marion Ahlenc-Gelas, Nicolas Kiavue, Gabriella Domitrescu, Lamiae El Amarti, Olivier Mir, Axel Le Cesne
Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy that occurs with unpredictable chemosensitivity and limited treatment options in the advanced setting. Prognosis is poor, and exploring new treatment options for such diseases is difficult because of its rarity. Clinical activity of trabectedin for advanced DSRCT was scarcely reported in the literature. Here, we report a series of six patients treated with trabectedin for an unresectable DSRCT. After receiving trabectedin, two patients had stable disease with a time to progression of 3 and 3...
January 2017: Anti-cancer Drugs
https://www.readbyqxmd.com/read/27760685/implementation-of-pre-exposure-prophylaxis-for-human-immunodeficiency-virus-infection-progress-and-emerging-issues-in-research-and-policy
#11
Carlos F Cáceres, Annick Borquez, Jeffrey D Klausner, Rachel Baggaley, Chris Beyrer
BACKGROUND: In this article, we present recent evidence from studies focused on the implementation, effectiveness and cost-effectiveness of pre-exposure prophylaxis (PrEP) for HIV infection; discuss PrEP scale-up to date, including the observed levels of access and policy development; and elaborate on key emerging policy and research issues to consider for further scale-up, with a special focus on lower-middle income countries. DISCUSSION: The 2015 WHO Early Release Guidelines for HIV Treatment and Prevention reflect both scientific evidence and new policy perspectives...
2016: Journal of the International AIDS Society
https://www.readbyqxmd.com/read/27759645/factors-associated-with-previously-undiagnosed-human-immunodeficiency-virus-infection-in-a-population-of-men-who-have-sex-with-men-and-male-to-female-transgender-women-in-lima-peru
#12
Joshua D Billings, Dvora L Joseph Davey, Kelika A Konda, Claire C Bristow, Jeremy Chow, Jeffrey D Klausner, Carlos F Cáceres
The aim of the study was to identify factors associated with undiagnosed human immunodeficiency virus (HIV) infection among men who have sex with men (MSM) and male-to-female transgender women in Lima, Peru.We analyzed characteristics of 378 MSM and transgender women recruited from 2 sexually transmitted infection (STI) clinics in Lima, Peru. Descriptive analyses compared: (A) HIV-uninfected, (B) previously undiagnosed HIV-infected, and (C) previously diagnosed HIV-infected participants. Multivariable logistic regression models identified: (1) correlates of previously undiagnosed HIV-infection among participants thought to be HIV-uninfected (B vs A); and (2) correlates of previously undiagnosed HIV-infection among HIV-infected participants (B vs C)...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27705739/canadian-pediatrics-society-position-statement-on-newborn-circumcision-a-risk-benefit-analysis-revisited
#13
Brian J Morris, Jeffrey D Klausner, John N Krieger, Bradley J Willcox, Pierre D Crouse, Neil Pollock
INTRODUCTION: The Canadian Pediatrics Society (CPS) recently released a position statement on early infant (newborn) male circumcision (EIMC). It concluded that since benefits do not exceed risks, circumcision should only be performed on boys in high-risk populations or circumstances. This contradicts recommendations by the American Academy of Pediatrics and the Centers for Disease Control and Prevention (CDC) whose policies each support more widespread implementation of EIMC. Here we review the CPS statement, particularly its risk-benefit analysis, to determine the basis for this disparity...
October 2016: Canadian Journal of Urology
https://www.readbyqxmd.com/read/27694561/screening-pregnant-women-in-the-2015-european-guideline-on-the-management-of-chlamydia-trachomatis-infections
#14
D Joseph Davey, M Alexandra, J D Klausner
No abstract text is available yet for this article.
October 2016: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27687517/number-of-evaluated-lymph-nodes-and-positive-lymph-nodes-lymph-node-ratio-and-log-odds-evaluation-in-early-stage-pancreatic-ductal-adenocarcinoma-numerology-or-valid-indicators-of-patient-outcome
#15
G Lahat, N Lubezky, F Gerstenhaber, E Nizri, M Gysi, M Rozenek, Y Goichman, I Nachmany, R Nakache, I Wolf, J M Klausner
BACKGROUND: We evaluated the prognostic significance and universal validity of the total number of evaluated lymph nodes (ELN), number of positive lymph nodes (PLN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) in a relatively large and homogenous cohort of surgically treated pancreatic ductal adenocarcinoma (PDAC) patients. METHODS: Prospectively accrued data were retrospectively analyzed for 282 PDAC patients who had pancreaticoduodenectomy (PD) at our institution...
September 29, 2016: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/27627412/effects-of-tangential-type-boundary-condition-discontinuities-on-the-accuracy-of-the-lattice-boltzmann-method-for-heat-and-mass-transfer
#16
Like Li, Nick AuYeung, Renwei Mei, James F Klausner
We present a systematic study on the effects of tangential-type boundary condition discontinuities on the accuracy of the lattice Boltzmann equation (LBE) method for Dirichlet and Neumann problems in heat and mass transfer modeling. The second-order accurate boundary condition treatments for continuous Dirichlet and Neumann problems are directly implemented for the corresponding discontinuous boundary conditions. Results from three numerical tests, including both straight and curved boundaries, are presented to show the accuracy and order of convergence of the LBE computations...
August 2016: Physical Review. E
https://www.readbyqxmd.com/read/27626361/global-challenges-in-human-immunodeficiency-virus-and-syphilis-coinfection-among-men-who-have-sex-with-men
#17
Chelsea P Roberts, Jeffrey D Klausner
Syphilis and human immunodeficiency virus (HIV) coinfection disproportionately affects men who have sex with men (MSM), and the rate of coinfection has been increasing over the last decade. HIV and syphilis coinfection is particularly challenging because the infections interact synergistically thereby increasing the risk of acquisition and transmission as well as accelerating disease progression. Areas covered: This paper reviews and summarizes the epidemiology, pathogenesis, diagnosis, clinical management and prevention of HIV and syphilis coinfection among MSM...
November 2016: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/27621268/adipose-induced-retroperitoneal-soft-tissue-sarcoma-tumorigenesis-a-potential-crosstalk-between-sarcoma-and-fat-cells
#18
Shelly Loewenstein, Nir Lubezky, Eran Nizri, Meir Zemel, Yishai Levin, Alon Savidor, Osnat Sher, Joseph M Klausner, Guy Lahat
: Previous data demonstrated that high retroperitoneal visceral fat content increases retroperitoneal soft-tissue sarcoma (RSTS) local recurrence and patients' mortality. Most RSTS tumors initiate and recur within visceral fat. The objective of the current study was to evaluate potential paracrine effects of visceral fat on RSTS. A xenograft model was used to evaluate in vivo effects of human visceral fat on STS growth. Tissue explants were prepared from visceral fat, and their conditioned medium (CM) was utilized for various in vitro experiments designed to evaluate growth, survival, migration, and invasion of STS and endothelial cells...
December 2016: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/27610340/critical-evaluation-of-unscientific-arguments-disparaging-affirmative-infant-male-circumcision-policy
#19
EDITORIAL
Brian J Morris, John N Krieger, Jeffrey D Klausner
We evaluate recent claims opposing infant male circumcision, a procedure now supported by the evidence-based policy of the American Academy of Pediatrics. We find those criticisms depend on speculative claims about the foreskin and obfuscation of the strong scientific evidence supporting pediatric policy development. An argument that circumcision should be delayed to allow a boy to make up his own mind as an adult fails to appreciate the psychological, scheduling and financial burdens later circumcision entails, so reducing the likelihood that it will occur...
August 8, 2016: World Journal of Clinical Pediatrics
https://www.readbyqxmd.com/read/27602569/risk-factors-associated-with-incident-syphilis-in-a-cohort-of-high-risk-men-in-peru
#20
Hayoung Park, Kelika A Konda, Chelsea P Roberts, Jorge L Maguiña, Segundo R Leon, Jesse L Clark, Thomas J Coates, Carlos F Caceres, Jeffrey D Klausner
BACKGROUND: Syphilis is concentrated among high-risk groups, but the epidemiology of syphilis reinfection is poorly understood. We characterized factors associated with syphilis incidence, including reinfection, in a high-risk cohort in Peru. METHODS: Participants in the NIMH CPOL trial were assessed at baseline and 2 annual visits with HIV/STI testing and behavioral surveys. Participants diagnosed with syphilis also attended 4- and 9-month visits. All participants underwent syphilis testing with RPR screening and TPPA confirmation...
2016: PloS One
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