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https://www.readbyqxmd.com/read/29198751/diabetes-resolution-after-one-anastomosis-gastric-bypass
#1
Adam Abu-Abeid, Yonatan Lessing, Niv Pencovich, Danit Dayan, Joseph M Klausner, Subhi Abu-Abeid
BACKGROUND: Diabetes and other obesity-related diseases are a worldwide pandemic that transcends geographic borders as well as socioeconomic levels. Currently, it is well known that medical treatment alone is insufficient to ensure adequate and sustainable weight loss and co-morbidity resolution. It has been well proven that bariatric surgery can produce almost immediate resolution of diabetes and other co-morbidities as well as long-term weight loss. OBJECTIVES: Here, we present our experience with the one anastomosis gastric bypass (OAGB) in terms of weight loss and diabetes resolution with 1 year of follow-up...
November 3, 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/29183269/high-incidence-of-extra-genital-gonorrheal-and-chlamydial-infections-among-high-risk-men-who-have-sex-with-men-and-transgender-women-in-peru
#2
Lao-Tzu Allan-Blitz, Kelika A Konda, Gino M Calvo, Silver K Vargas, Segundo R Leon, Eddy R Segura, Carlos F Caceres, Jeffrey D Klausner
Extra-genital Neisseria gonorrhoeae and Chlamydia trachomatis infections are associated with antimicrobial resistance and HIV acquisition. We analyzed data from a cohort of men who have sex with men (MSM) and transgender women followed quarterly for two years in Peru. Incident cases were defined as positive N. gonorrhoeae or C. trachomatis nucleic acid tests during follow-up. Repeat positive tests were defined as reinfection among those with documented treatment. We used generalized estimating equations to calculate adjusted incidence rate ratios (aIRRs)...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29124488/t-helper-1-immune-response-in-metastatic-lymph-nodes-of-pancreatic-ductal-adenocarcinoma-a-marker-for-prolonged-survival
#3
Eran Nizri, Neta Sternbach, Shoshi Bar-David, Amir Ben-Yehuda, Fabian Gerstenhaber, Tali Ofir, Ido Wolf, Gilad Weiner, Guy Lahat, Joseph Klausner
BACKGROUND: Although lymph node (LN) metastases is considered a grave prognostic sign in pancreatic ductal adenocarcinoma (PDAC), patients with positive lymph nodes (PLN) constitute a heterogeneous group. Our purpose was to identify morphological and immune parameters in the primary tumor and in PLN of resected PDAC patients, which could further stratify these patients to different subgroups. METHODS: We retrospectively evaluated histological and immunohistochemical characteristics of 66 patients with PDAC who were operated at our institution...
November 9, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29097418/prevalence-and-treatment-outcomes-of-routine-chlamydia-trachomatis-neisseria-gonorrhoeae-and-trichomonas-vaginalis-testing-during-antenatal-care-gaborone-botswana
#4
Adriane Wynn, Doreen Ramogola-Masire, Ponatshego Gaolebale, Neo Moshashane, Ontiretse Sickboy, Sofia Duque, Elizabeth Williams, Klara Doherty, Jeffrey D Klausner, Chelsea Morroni
OBJECTIVES: Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) are curable, mostly asymptomatic, STIs that cause adverse maternal and perinatal outcomes. Most countries do not test for those infections during antenatal care. We implemented a CT, NG and TV testing and treatment programme in an antenatal clinic in Gaborone, Botswana. METHODS: We conducted a prospective study in the antenatal clinic at Princess Marina Hospital in Gaborone, Botswana...
November 2, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29093212/legionella-pneumophila-csra-regulates-a-metabolic-switch-from-amino-acid-to-glycerolipid-metabolism
#5
Ina Häuslein, Tobias Sahr, Pedro Escoll, Nadine Klausner, Wolfgang Eisenreich, Carmen Buchrieser
Legionella pneumophila CsrA plays a crucial role in the life-stage-specific expression of virulence phenotypes and metabolic activity. However, its exact role is only partly known. To elucidate how CsrA impacts L. pneumophila metabolism we analysed the CsrA depended regulation of metabolic functions by comparative (13)C-isotopologue profiling and oxygen consumption experiments of a L. pneumophila wild-type (wt) strain and its isogenic csrA(-) mutant. We show that a csrA(-) mutant has significantly lower respiration rates when serine, alanine, pyruvate, α-ketoglutarate or palmitate is the sole carbon source...
November 2017: Open Biology
https://www.readbyqxmd.com/read/29046409/using-treponemal-assay-signal-strength-cut-off-ratios-to-predict-syphilis-infection
#6
Claire C Bristow, Jeffrey D Klausner
Syphilis screening using the reverse algorithm, a treponemal test for screening followed by a non-treponemal test if reactive, is increasingly being used. This algorithm has several advantages including use of an automated screening test, saving on laboratory time and costs as well as detection of very early syphilis infection. However, under this algorithm, in situations where the treponemal result is positive and the non-treponemal result is non-reactive a second treponemal test must be performed, which may actually lead to inefficiencies in the laboratory...
October 18, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29043467/do-subjective-alcohol-screening-tools-correlate-with-biomarkers-among-high-risk-transgender-women-and-men-who-have-sex-with-men-in-lima-peru
#7
M C Herrera, K A Konda, S R Leon, B Brown, G M Calvo, H J Salvatierra, C F Caceres, J D Klausner, R Deiss
Alcohol abuse can influence sexual risk behavior; however, its measurement is not straightforward. This study compared self-reported alcohol use, via the AUDIT and CAGE, with levels of phosphatidylethanol (Peth), a phospholipid biomarker that forms with chronic, heavy drinking, among high-risk MSM and TW in Lima, Peru. Chi square, Fisher's exact, Wilcoxon ranksum tests compared the instruments. Receiver operating curves determined sensitivity and specificity of the self-reported measures. Among 69 MSM and 17 TW, PEth was positive for 86% (95% CI 77-93%) of participants, while 67% reported binge-drinking in the last 2 weeks...
November 2017: AIDS and Behavior
https://www.readbyqxmd.com/read/29021154/laboratory-validation-of-xpert%C3%A2-ct-ng-and-tv-testing-as-performed-by-nurses-at-three-primary-healthcare-facilities-in-south-africa
#8
Remco P H Peters, Lindsey de Vos, Maduna Liteboho, Maanda Mudau, Jeffrey D Klausner, Marleen M Kock, Andrew Medina-Marino
The introduction of molecular diagnostic tests provides an important step to address the burden of sexually transmitted infections (STIs), especially Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV).….
October 11, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/28984579/follow-up-of-patients-undergoing-oncoplastic-surgery-more-palpable-masses-and-benign-biopsies
#9
Yoav Amitai, Orit Golan, Yoav Barnea, Joseph Klausner, Tehillah S Menes
BACKGROUND: Oncoplastic reconstruction is increasingly used in the management of women undergoing breast conserving surgery. We examined the findings on breast exam and imaging of patients who underwent breast conservation with or without oncoplastic reconstruction. OBJECTIVE: We hypothesized that patients undergoing immediate breast reconstruction would present with more palpable and imaging abnormalities compared to lumpectomy alone and undergo therefore more biopsies...
October 3, 2017: Breast Disease
https://www.readbyqxmd.com/read/28930022/diagnosis-of-fatal-human-case-of-st-louis-encephalitis-virus-infection-by-metagenomic-sequencing-california-2016
#10
Charles Y Chiu, Lark L Coffey, Jamie Murkey, Kelly Symmes, Hannah A Sample, Michael R Wilson, Samia N Naccache, Shaun Arevalo, Sneha Somasekar, Scot Federman, Doug Stryke, Paul Vespa, Gary Schiller, Sharon Messenger, Romney Humphries, Steve Miller, Jeffrey D Klausner
We used unbiased metagenomic next-generation sequencing to diagnose a fatal case of meningoencephalitis caused by St. Louis encephalitis virus in a patient from California in September 2016. This case is associated with the recent 2015-2016 reemergence of this virus in the southwestern United States.
October 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28891022/converting-a-sleeve-gastrectomy-to-a-gastric-bypass-for-weight-loss-failure-is-it-worth-it
#11
Nadav Nevo, Subhi Abu-Abeid, Guy Lahat, Joseph Klausner, Shai M Eldar
BACKGROUND: Sleeve gastrectomy (SG) is gaining popularity and has become the procedure of choice for many bariatric surgeons. Long-term weight loss failure is not uncommon. The preferred revisional procedure for these patients is still under debate. OBJECTIVE: The objective of this study was to assess the safety and efficacy of laparoscopic gastric bypass as a revisional surgery for sleeve gastrectomy patients with weight loss failure. SETTING: The study was done at a bariatric surgery center in a university hospital...
September 10, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28879552/considerations-for-hartmann-s-reversal-and-hartmann-s-reversal-outcomes-a-multicenter-study
#12
Nir Horesh, Yonatan Lessing, Yaron Rudnicki, Ilan Kent, Haguy Kammar, Almog Ben-Yaacov, Yael Dreznik, Hagit Tulchinsky, Shmuel Avital, Eli Mavor, Nir Wasserberg, Hanoch Kashtan, Joseph M Klausner, Mordechai Gutman, Oded Zmora
PURPOSE: Hartmann's procedure is commonly practiced in emergent cases with the restoration of bowel continuity planned at a second stage. This study assessed the rate of restorations following Hartmann's procedure and evaluated factors affecting decision-making. METHODS: Data on patient demographics, comorbidities, causes for Hartmann's procedure, reversal rate, and complications were collected in a multicenter retrospective cohort study of patients who underwent Hartmann's procedure in five medical centers...
November 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28876326/keep-screening-maternal-gonococcal-infection-and-adverse-birth-outcomes
#13
Chelsea Lee Shannon, Jeffrey D Klausner
No abstract text is available yet for this article.
April 28, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/28866636/transient-aortitis-documented-by-positron-emission-tomography-in-a-case-series-of-men-and-transgender-women-infected-with-syphilis
#14
Dvora Joseph Davey, Noah Kojima, Kelika A Konda, Pawan Gupta, Segundo R Leon, Gino M Calvo, Carlos F Caceres, Jeffrey D Klausner
OBJECTIVES: Syphilis infection persists globally contributing to preventable and treatable morbidity and mortality. How extensive early syphilis disseminates is unknown. To better understand the relationship between early syphilis infection and inflammation over time, our study enrolled six individuals recently infected with syphilis for sequential positron emission tomography (PET) scans. METHODS: We evaluated a case series of six individuals with high syphilis titres (two secondary, two early latent and two latent, unknown duration, but with high titre) who received sequential PET scans to assess inflammation over time and its response to treatment...
September 2, 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/28846743/evaluation-of-two-4th-generation-point-of-care-assays-for-the-detection-of-human-immunodeficiency-virus-infection
#15
Chrysovalantis Stafylis, Jeffrey D Klausner
BACKGROUND: Fourth generation assays detect simultaneously antibodies for HIV and the p24 antigen, identifying HIV infection earlier than previous generation tests. Previous studies have shown that the Alere Determine HIV-1/2 Combo has lower than anticipated performance in detecting antibodies for HIV and the p24 antigen. Furthermore, there are currently very few studies evaluating the performance of Standard Diagnostics BIOLINE HIV Ag/Ab Combo. OBJECTIVE: To evaluate the performance of the Alere Determine HIV-1/2 Combo and the Standard Diagnostics BIOLINE HIV Ag/Ab Combo in a panel of frozen serum samples...
2017: PloS One
https://www.readbyqxmd.com/read/28843985/laparoscopic-sleeve-gastrectomy-for-diabetics-5-year-outcomes
#16
Yonatan Lessing, Niv Pencovich, Guy Lahat, Joseph M Klausner, Subhi Abu-Abeid, Shai Meron Eldar
OBJECTIVE: Although the laparoscopic sleeve gastrectomy (SG) is increasingly performed for morbid obesity, gastric bypass is still considered by many to be the gold standard procedure for obese diabetic patients. The aim of this study was to assess the long-term results of SG in morbidly obese patients with type 2 diabetes. METHODS: Diabetic patients who underwent SG at a single center between 2009 and 2011 were included. Outcomes assessed included postoperative complications, weight loss, and resolution or improvement in co-morbidities with an emphasis on diabetes, including glycated hemoglobin (HbA1C) and medication status...
October 2017: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
https://www.readbyqxmd.com/read/28842209/longitudinal-gender-disparity-in-female-urology-resident-primary-authorship-at-an-american-urological-association-sectional-meeting
#17
Tony R Lin, Neil J Kocher, Adam P Klausner, Jay D Raman
OBJECTIVE: To further evaluate the academic representation of female urology residents in the United States, we reviewed abstracts from the Mid-Atlantic American Urological Association (MA-AUA) sectional meetings to determine if the recent increase in the number of female urology residents mirrored an increase in this group's abstract authorship. MATERIALS AND METHODS: Full text abstracts from the MA-AUA meetings were analyzed from 2008 to 2014 excluding 1 joint section meeting...
August 24, 2017: Urology
https://www.readbyqxmd.com/read/28835340/quantification-of-bladder-wall-biomechanics-during-urodynamics-a-methodologic-investigation-using-ultrasound
#18
Anna S Nagle, Adam P Klausner, Jary Varghese, Rachel J Bernardo, Andrew F Colhoun, Robert W Barbee, Laura R Carucci, John E Speich
Overactive bladder is often characterized by biomechanical changes in the bladder wall, but there is no established method to measure these changes in vivo. The goal of this study was to develop a novel method to determine detrusor wall biomechanical parameters during urodynamics through the incorporation of transabdominal ultrasound imaging. Individuals with overactive bladder (OAB) underwent ultrasound imaging during filling. The fill rate was 10% of the cystometric capacity per minute as determined by an initial fill...
August 16, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28820375/epidemiology-of-neisseria-gonorrhoeae-gyrase-a-genotype-los-angeles-california-usa
#19
Ashima A Bhatti, Lao-Tzu Allan-Blitz, Mariana Castrejon, Romney M Humphries, Peera Hemarajata, Jeffrey D Klausner
We investigated the epidemiology of the mutant gyrase A gene, a reliable predictor of ciprofloxacin resistance, in Neisseria gonorrhoeae infections at UCLA Health in Los Angeles, California, USA, during November 1, 2015-August 31, 2016. Among 110 patients with N. gonorrhoeae infections, 48 (44%) had the mutant gyrase A gene.
September 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/28799824/high-prevalence-of-asymptomatic-sexually-transmitted-infections-among-human-immunodeficiency-virus-infected-pregnant-women-in-a-low-income-south-african-community
#20
Maanda Mudau, Remco P Peters, Lindsey De Vos, Dawie H Olivier, Dvora J Davey, Edwin S Mkwanazi, James A McIntyre, Jeffrey D Klausner, Andrew Medina-Marino
There is a lack of evidence on the burden of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG) and Trichomonas vaginalis (TV) among HIV-infected pregnant women in South Africa. We conducted a cross-sectional analysis of HIV-infected pregnant women in two healthcare facilities in a South African township to determine the prevalence of CT, NG and TV. HIV-infected pregnant women were recruited during the first antenatal care visit for their current pregnancy and requested to self-collect vulvovaginal swab specimens...
January 1, 2017: International Journal of STD & AIDS
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