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Rhodiola rosea

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https://www.readbyqxmd.com/read/29749547/salidroside-inhibits-the-proliferation-and-migration-of-gastric-cancer-cells-via-suppression-of-src%C3%A2-associated-signaling-pathway-activation-and-heat-shock-protein-70-expression
#1
Zhilin Qi, Tuo Tang, Lili Sheng, Yunfei Ma, Yinhua Liu, Liang Yan, Shimei Qi, Liefeng Ling, Yao Zhang
Salidroside, an active ingredient extracted from the Rhodiola rosea plant, has potential anti‑tumor effects. However, the effects of salidroside on gastric cancer cell proliferation and migration remain unclear. In the present study, the inhibitory effects of salidroside on gastric cancer cell proliferation, migration and invasion and the molecular mechanisms underlying these effects were investigated. The human gastric cancer cell line, BGC‑823, was treated with different concentrations of salidroside (200, 400 and 600 µg/ml)...
May 3, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29725300/salidroside-promotes-the-pathological-%C3%AE-synuclein-clearance-through-ubiquitin-proteasome-system-in-sh-sy5y-cells
#2
Tao Li, Yang Feng, Ruixin Yang, Leitao Wu, Ruru Li, Lu Huang, Qian Yang, Jianzong Chen
Parkinson's disease (PD) is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the presence of Lewy bodies (LBs) in the surviving SNc neurons. LBs formation is caused by the accumulation of α-synuclein (α-syn) or phosphorylated α-syn at serine-129 (pSer129-α-syn), which is implicated in the pathological progression of PD. Salidroside (Sal), the main active ingredient of the root of Rhodiola rosea L ., has been reported to have potent neuroprotective properties in our previous investigations...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29693192/salidroside-prevents-skin-carcinogenesis-induced-by-dmba-tpa-in-a-mouse-model-through-suppression-of-inflammation-and-promotion-of-apoptosis
#3
Ying-Hui Kong, Su-Ping Xu
Salidroside (SR) is a main component of Rhodiola rosea L. and exhibits a variety of pharmacologic properties. The present study was carried out to explore the potential effect of SR against skin cancer induced by 7,12-dimethylbenz(a)anthracene (DMBA) and 12-O-tetradecanoylphorbol-13‑acetate (TPA) in female Institute for Cancer Research (ICR) mice and to reveal the underlying molecular targets regulated by SR. The mice were randomly divided into 4 groups: control, DMBA/TPA, DMBA/TPA+SR (20 mg/kg) and DMBA/TPA+SR (40 mg/kg)...
April 18, 2018: Oncology Reports
https://www.readbyqxmd.com/read/29616120/salidroside-induces-apoptosis-in-human-ovarian-cancer-skov3-and-a2780-cells-through-the-p53-signaling-pathway
#4
Ge Yu, Na Li, Yan Zhao, Wei Wang, Xiao-Ling Feng
Salidroside is one of the most potent compounds extracted from the plant Rhodiola rosea , and its cardiovascular protective effects have been studied extensively. However, the role of salidroside in human ovarian carcinoma remains unknown. The aim of the current study was to investigate the effects of salidroside on the proliferation and apoptosis of SKOV3 and A2780 cells using MTT assay and acridine orange/ethidium bromide staining. Salidroside activated caspase-3 and upregulated the levels of apoptosis-inducing factor, Bcl-2-associated X and Bcl-2-associated death promoter (Bad) proteins...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29599913/time-dependent-effects-of-late-onset-dietary-intake-of-salidroside-on-lifespan-and-age-related-biomarkers-of-the-annual-fish-nothobranchius-guentheri
#5
Xia Wang, Xiaoyuan Du, Yang Zhou, Su Wang, Feng Su, Shicui Zhang
One of the most studied and widely accepted conjectures of aging process is the oxidative stress theory. Previous studies have shown that salidroside can protect D-galactose-induced mouse model against aging and a formulation of Rhodiola rosea extracts (SHR-5) containing salidroside increases lifespan of fruit fly. However, direct evidence linking salidroside itself with the observed anti-aging effect in vivo and relevant molecular mechanisms are poorly defined. In this study, we first demonstrated that salidroside exhibited a time-dependent effect, and late-onset long-term salidroside dietary intake extended the lifespan in the annual fish Nothobranchius guentheri ...
March 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29593538/salidroside-inhibits-myogenesis-by-modulating-p-smad3-induced-myf5-transcription
#6
Peng Zhang, Wenjiong Li, Lu Wang, Hongju Liu, Jing Gong, Fei Wang, Xiaoping Chen
Aim: Salidroside is an active compound extracted from Rhodiola rosea which is used to alleviate fatigue and enhance endurance in high altitude regions. Some studies have demonstrated that salidroside can affect precursor cell differentiation in hematopoietic stem cells, erythrocytes, and osteoblasts. The aim of this study was to investigate the effect of salidroside on myoblast differentiation and to explore the underlying molecular mechanisms of this effect. Methods: C2C12 myoblast cells were treated with different concentrations of salidroside in differentiation media...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29584652/identification-of-ellagic-acid-from-plant-rhodiola-rosea-l-as-an-anti-ebola-virus-entry-inhibitor
#7
Qinghua Cui, Ruikun Du, Manu Anantpadma, Adam Schafer, Lin Hou, Jingzhen Tian, Robert A Davey, Han Cheng, Lijun Rong
The recent 2014-2016 West African Ebola virus epidemic underscores the need for the development of novel anti-Ebola therapeutics, due to the high mortality rates of Ebola virus infections and the lack of FDA-approved vaccine or therapy that is available for the prevention and treatment. Traditional Chinese medicines (TCMs) represent a huge reservoir of bioactive chemicals and many TCMs have been shown to have antiviral activities. 373 extracts from 128 TCMs were evaluated using a high throughput assay to screen for inhibitors of Ebola virus cell entry...
March 27, 2018: Viruses
https://www.readbyqxmd.com/read/29581730/the-impact-of-rhodiola-rosea-on-the-gut-microbial-community-of-drosophila-melanogaster
#8
Khachik E Labachyan, Dara Kiani, Evgueni A Sevrioukov, Samuel E Schriner, Mahtab Jafari
Background: The root extract of Rhodiola rosea has historically been used in Europe and Asia as an adaptogen, and similar to ginseng and Shisandra , shown to display numerous health benefits in humans, such as decreasing fatigue and anxiety while improving mood, memory, and stamina. A similar extract in the Rhodiola family, Rhodiola crenulata , has previously been shown to confer positive effects on the gut homeostasis of the fruit fly, Drosophila melanogaster. Although, R. rosea has been shown to extend lifespan of many organisms such as fruit flies, worms and yeast, its anti-aging mechanism remains uncertain...
2018: Gut Pathogens
https://www.readbyqxmd.com/read/29341943/beneficial-effect-of-chronic-treatment-with-extracts-from-rhodiola-rosea-l-and-curcuma-longa-l-on-the-immunoreactivity-of-animals-subjected-to-a-chronic-mild-stress-model
#9
Liliya V Vasileva, Kremena Е Saracheva, Mariya V Ivanovska, Atanaska P Petrova, Emir Sucouglu, Mariana A Murdjeva, Damyanka P Getova-Spasova
BACKGROUND: Recent studies have suggested increased levels of pro-inflammatory cytokines in depression. AIM: The present study aimed to evaluate the effect of extracts from Rhodiola and Curcuma on immunoreactivity of animals subjected to a chronic mild stress (CMS) model followed by lipopolysaccharide-induced inflammation. MATERIALS AND METHODS: Male Wistar rats (n=56) divided in 7 groups were treated orally with: distilled water 10 ml/kg (control and CMS model groups); Rhodiola 250 mg/kg; Rhodiola 500 mg/kg; Curcuma 250 mg/kg; Curcuma 500 mg/kg, Rhodiola 250 mg/kg and Curcuma 250 mg/kg...
December 20, 2017: Folia Medica
https://www.readbyqxmd.com/read/29325481/stress-management-and-the-role-of-rhodiola-rosea-a-review
#10
Ion-George Anghelescu, David Edwards, Erich Seifritz, Siegfried Kasper
OBJECTIVE: Stress describes the physiological reaction to threat or pressure, which manifests as physical symptoms of exhaustion or energy loss and psychological symptoms, including irritability or tension. If untreated, chronic stress or burnout may develop, both are areas of unmet medical need. Evidence-based treatment and prevention measures are needed. METHODS: Prevention strategies and existing treatment options for stress-related symptoms were evaluated to establish criteria for an adequate pharmacological approach to stress...
January 11, 2018: International Journal of Psychiatry in Clinical Practice
https://www.readbyqxmd.com/read/29277428/complete-pathway-elucidation-and-heterologous-reconstitution-of-rhodiola-salidroside-biosynthesis
#11
Michael P Torrens-Spence, Tomáš Pluskal, Fu-Shuang Li, Valentina Carballo, Jing-Ke Weng
Salidroside is a bioactive tyrosine-derived phenolic natural product found in medicinal plants under the Rhodiola genus. In addition to their anti-fatigue and anti-anoxia roles in traditional medicine, Rhodiola total extract and salidroside have also displayed medicinal properties as anti-cardiovascular diseases and anti-cancer agents. The resulting surge in global demand of Rhodiola plants and salidroside has driven some species close to extinction. Here, we report the full elucidation of the Rhodiola salidroside biosynthetic pathway utilizing the first comprehensive transcriptomics and metabolomics datasets for Rhodiola rosea...
January 8, 2018: Molecular Plant
https://www.readbyqxmd.com/read/29246220/inhibition-of-autophagy-enhances-synergistic-effects-of-salidroside-and-anti-tumor-agents-against-colorectal-cancer
#12
Hai Li, Chen Chen
BACKGROUND: Various plant extracts have been suggested to be used as auxiliary agents in chemotherapy considering their anti-proliferative effect on cancer cells. However, recent reports reveal that plant extracts may function as inducers of autophagy of cancer cells. In general, autophagy confers survival advantage for cells responding to stress conditions, thus representing an important mechanism for chemo-resistance. This study was aimed to investigate the effectiveness of combined use of Salidroside (Sal, a phenylpropanoid glycosides from Rhodiola rosea L) with anti-tumor agents against colorectal cancer (CRC) cells, and moreover to evaluate the potential role of autophagy in the combined therapy...
December 16, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/29242120/osteoprotective-effects-of-salidroside-in-ovariectomized-mice-and-diabetic-mice
#13
Xiang-Fan Chen, Xiao-Li Li, Min Yang, Yan Song, Yan Zhang
Salidroside, an active constituent from the root of Rhodiola rosea L., has multiple pharmacological effects, such as anti-cancer, anti-inflammatory and anti-oxidative properties, etc. However, its protective effect on bone tissue via regulating calcium homeostasis is yet to be determined. This study was performed to investigate if salidroside could protect against bone injuries induced by estrogen deficiency or hyperglycemia through modulating calcium homeostasis. Ovariectomized (OVX) mice and diabetic mice were treated with salidroside (20mg/kg) for 6 weeks...
January 15, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29154110/authentication-of-eleutherococcus-and-rhodiola-herbal-supplement-products-in-the-united-kingdom
#14
Markus Ruhsam, Peter M Hollingsworth
Siberian ginseng (Eleutherococcus senticosus, Araliaceae) and roseroot (Rhodiola rosea, Rosaceae) are popular herbal supplements which have been shown to improve resilience to conditions such as stress and exhaustion. Using DNA barcoding methods we tested 25 Siberian ginseng and 14 roseroot products which are widely available to UK customers to test whether the herbal ingredient stated on the label is also in the product. All Siberian ginseng supplements contained E. senticosus, however, 36% also contained an Eleutherococcus species other than E...
February 5, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29093682/salidroside-a-natural-antioxidant-improves-%C3%AE-cell-survival-and-function-via-activating-ampk-pathway
#15
Linjie Ju, Xiaohua Wen, Chunjun Wang, Yingjie Wei, Yunru Peng, Yongfang Ding, Liang Feng, Luan Shu
Aim: The enhanced oxidative stress contributes to progression of type 2 diabetes mellitus (T2DM) and induces β-cell failure. Salidroside is a natural antioxidant extracted from medicinal food plant Rhodiola rosea . This study was aimed to evaluate protective effects of salidroside on β-cells against diabetes associated oxidative stress. Methods and Results: In diabetic db/db and high-fat diet-induced mice, we found salidroside ameliorated hyperglycemia and relieved oxidative stress. More importantly, salidroside increased β-cell mass and β-cell replication of diabetic mice...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29031534/salidroside-alleviates-high-glucose-induced-oxidative-stress-and-extracellular-matrix-accumulation-in-rat-glomerular-mesangial-cells-by-the-txnip-nlrp3-inflammasome-pathway
#16
Shiying Wang, Xinxin Zhao, Suxia Yang, Baoping Chen, Jun Shi
Diabetic nephropathy (DN) is a metabolic disease characterized by mesangial cell proliferation and extracellular matrix (ECM) accumulation. Salidroside (SAL) is the major ingredient in Rhodiola rosea and possesses beneficial effects on DN. This study aimed to evaluate the effect of SAL on high glucose (HG)-induced oxidative stress and ECM accumulation and the underlying mechanism. Rat glomerular mesangial cells HBZY-1 were induced by high glucose (HG) in the presence or absence of SAL. Cell proliferation was measured by CCK-8 assay...
December 25, 2017: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28968926/immunopotentiating-significance-of-conventionally-used-plant-adaptogens-as-modulators-in-biochemical-and-molecular-signalling-pathways-in-cell-mediated-processes
#17
REVIEW
Pardeep Kaur, Robin, Victor O Makanjuola, Rohit Arora, Balbir Singh, Saroj Arora
Natural products are of great surge in the identification of chemopreventive agents and biologically active molecules for the development of new promising therapeutic agents. These agents influence the cascade of biochemical and molecular signalling pathways involved in numerous physiological and pathological processes. The natural agents combat the dogma associated with the most dreaded, unconquered health concern and a multigenic disease- cancer. A category of plants known as adaptogens maintain perturbed homoeostasis, augment adaptations to noxious stimuli (exposure to cold, heat, pain, general stress, infectious organisms) and offer endurance to attenuate several disorders in human beings...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28931916/salidroside-ameliorates-sepsis-induced-acute-lung-injury-and-mortality-via-downregulating-nf-%C3%AE%C2%BAb-and-hmgb1-pathways-through-the-upregulation-of-sirt1
#18
Kuo-Cheng Lan, Sung-Chuan Chao, Hsiao-Yi Wu, Chia-Lien Chiang, Ching-Chia Wang, Shing-Hwa Liu, Te-I Weng
Sepsis is a life-threatening medical condition. Salidroside, a substance isolated from Rhodiola rosea, possesses antioxidant and anti-inflammatory properties. The effect and mechanism of salidroside on sepsis-induced acute lung injury still remains to be well clarified. Here, we investigated the effect and mechanism of salidroside on septic mouse models and explored the role of salidroside-upregulated SIRT1. Salidroside inhibited the inflammatory responses and HMGB1 productions in bacterial lipopolysaccharide (LPS)-treated macrophages and mice...
September 20, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28901519/salidroside-a-scavenger-of-ros-enhances-the-radioprotective-effect-of-ex-rad%C3%A2-via-a-p53-dependent-apoptotic-pathway
#19
Tian Feng, Libin Wang, Nan Zhou, Chang Liu, Jiahui Cui, Rangxin Wu, Juan Jing, Shengyong Zhang, Hui Chen, Siwang Wang
Salidroside (Sal), the predominant component of a Chinese medicinal herb, Rhodiola rosea L., has become an attractive bioagent due to its significant anti-radiation, antioxidant and immune adjustment effects. We explored the radioprotective effect of Sal to ascertain whether it could enhance the anti-radiation effect of ON 01210.Na (Ex-RAD®) in vivo and in vitro, and elucidate its underlying mechanism. Our data demonstrated that Sal inhibited radiation-induced apoptosis, scavenged reactive oxygen species (ROS), and decreased the DNA damage of human umbilical vein endothelial cells (HUVECs)...
November 2017: Oncology Reports
https://www.readbyqxmd.com/read/28873320/influence-of-rhodiola-rosea-on-the-heat-acclimation-process-in-young-healthy-men
#20
Saima Timpmann, Anthony C Hackney, Maria Tamm, Kairi Kreegipuu, Eve Unt, Vahur Ööpik
The adaptogen Rhodiola rosea (RR) may mitigate stress responses and have beneficial effects on endurance capacity (EC) and mental performance. Heat acclimation (HA) improves EC in the heat, but the potential impact of RR on the HA process is unknown. Therefore, our intent was to determine if RR has a positive impact on HA. Twenty male subjects (age, 22.5 ± 3.0 years) completed 2 EC tests involving walking (6 km·h-1 ) until volitional exhaustion in a climate chamber (air temperature, 42 °C; relative humidity, 18%) before (H1) and after (H2) an 8-day HA period...
January 2018: Applied Physiology, Nutrition, and Metabolism, Physiologie Appliquée, Nutrition et Métabolisme
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