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Rhodiola rosea

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https://www.readbyqxmd.com/read/27854435/-rhodiola-rosea-and-its-neuropsychotropic-effects
#1
Jan Juřica, Tereza Koupá
The paper reviews the neuropsychotropic effects of Rhodiola rosea, a succulent perennial plant which is native to dry, high-altitude regions of the northern hemisphere. The most valued part of the plant is its rhizome, which has a rose-like fragrance. In the available literature, there is a large number of mentions of its healing properties; nonetheless, only few of them are based on reliable scientific evidence. Of the neuropsychotropic effects, there are mentions of anxiolytic, antidepressant, neuroprotective and pro- cognitive properties and nonspecific "adaptogenic" effects...
2016: Ceská a Slovenská Farmacie
https://www.readbyqxmd.com/read/27809414/salidroside-protects-against-homocysteine-induced-injury-in-huvecs-via-the-regulation-of-endoplasmic-reticulum-stress
#2
Lin Zhu, Fang Jia, Jiang Wei, Yang Yu, Tianhong Yu, Yanjun Wang, Jianhui Sun, Guanghua Luo
INTRODUCTION: Previous studies showed that homocysteine(Hcy) could injure vascular endothelial cells via several mechanisms, including its promotion of oxidative stress pathway and endoplasmic reticulum stress (ER-stress) pathway. Salidroside(SAL) is an active component of Rhodiola rosea with documented antioxidative properties. Emerging evidence conformed that SAL attenuated Hcy induced endothelial dysfunction by reducing oxidative stress. However, its role in ER-stress pathway remains un-clarified...
November 3, 2016: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/27794583/comparative-study-on-the-protective-effects-of-salidroside-and-hypoxic-preconditioning-for-attenuating-anoxia-induced-apoptosis-in-pheochromocytoma-pc12-cells
#3
Yao Hu, Xiumei Lv, Jing Zhang, Xianli Meng
BACKGROUND Hypoxia is an important sign that can result from body injuries or a special condition such as being at a high altitude or deep water diving. In the current studies, hypoxic preconditioning (HPC) plays a key role in reducing hypoxia-induced apoptosis. We aimed to study the pharmacologic preconditioning effects of salidroside versus those of HPC in hypoxia-/anoxia-induced apoptosis in PC12 cells (pheochromocytoma). MATERIAL AND METHODS PC12 cells were treated by different experimental conditions: control condition, hypoxia condition, HPC condition, low-/middle-/high-dose condition of salidroside, cyclosporine A (CsA), and oratractyloside (ATR)...
October 30, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27779653/anti-inflammatory-effect-of-salidroside-on-phorbol-12-myristate-13-acetate-plus-a23187-mediated-inflammation-in-hmc-1-cells
#4
Da-Wun Yang, Ok-Hwa Kang, Young-Seob Lee, Sin-Hee Han, Sang-Won Lee, Seon-Woo Cha, Yun-Soo Seo, Su-Hyun Mun, Ryong Gong, Dong-Won Shin, Dong-Yeul Kwon
Salidroside [2-(4-hydroxyphenyl)ethyl β-D-gluco-pyranoside (SAS)] has been identified as the most potent ingredient of the plant Rhodiola rosea L. Previous studies have demonstrated that it possesses a number of pharmacological properties, including anti-aging, anti-fatigue, antioxidant, anticancer and anti-inflammatory properties. In this study, to ascertain the molecular mechanisms responsible for the anti-inflammatory activity of SAS, we used phorbol-12-myristate-13-acetate (PMA) plus A23187 to induce inflammation in human mast cell line-1 (HMC-1)...
October 18, 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27748934/salidroside-induces-apoptosis-and-autophagy-in-human-colorectal-cancer-cells-through-inhibition-of-pi3k-akt-mtor-pathway
#5
Xiang-Jun Fan, Yao Wang, Lei Wang, Mingyan Zhu
The role of salidroside in colon cancer remains unknown. Here we show that salidroside, a phenylpropanoid glycoside extracted from Rhodiola rosea, exhibited potent anti-proliferative properties in human colorectal cancer cells via inducing apoptosis and autophagy. We ascertained that salidroside exerts an inhibitory effect on the proliferation of human colorectal cancer cells in a dose-dependent manner. In addition, salidroside induced cell apoptosis, accompanied by an increase of chromatin condensation and nuclear fragmentation, and a decrease of Bcl-2/Bax protein expression ratio...
September 30, 2016: Oncology Reports
https://www.readbyqxmd.com/read/27720849/beneficial-effect-of-commercial-rhodiolaextract-in-rats-with-scopolamine-induced-memory-impairment-on-active-avoidance
#6
Liliya V Vasileva, Damianka P Getova, Nina D Doncheva, Andrey S Marchev, Milen I Georgiev
: Rhodiola rosea L., family Crassulaceae also known as Golden Root or Arctic root is one of the most widely used medicinal plants with effect on cognitive dysfunction, psychological stress and depression. The aim of the study was to examine the effect of a standardized commercial Rhodiola extract on learning and memory processes in naive rats as well as its effects in rats with scopolamine-induced memory impairment. MATERIALS AND METHODS: Sixty male Wistar rats were used in the study...
October 5, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27698696/rhodiola-rosea-folic-acid-zinc-and-biotin-endep-%C3%A2-is-able-to-improve-ejaculatory-control-in-patients-affected-by-lifelong-premature-ejaculation-results-from-a-phase-i-ii-study
#7
Tommaso Cai, Paolo Verze, Paolo Massenio, Daniele Tiscione, Gianni Malossini, Luigi Cormio, Giuseppe Carrieri, Vincenzo Mirone
The therapeutic armamentarium currently available for the treatment of premature ejaculation (PE) is not highly satisfactory. However, phytotherapeutics appear to be an interesting option for PE management. The present study aimed to evaluate the tolerability and efficacy of a phytotherapeutic combination of Rhodiola rosea, folic acid, biotin and zinc (EndEP(®)) in the treatment of patients affected by lifelong PE. All patients affected by lifelong PE who were attending three Urological Institutions from July to December 2014 were enrolled in this prospective, multicentre, phase I-II study...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27627465/salidroside-s-protection-against-uvb-mediated-oxidative-damage-and-apoptosis-is-associated-with-the-upregulation-of-nrf2-expression
#8
Yuan Xiao-Ying, Pang Xiao-Wen, Zhang Guo-Qiang, Guo Jian-You
BACKGROUND: Salidroside is the major active component of Rhodiola rosea, a traditional Chinese herbal medicine used for protection against ultraviolet (UV) radiation. OBJECTIVES: This study investigated whether salidroside can protect skin from ultraviolet B (UVB)-induced oxidative damage in human immortalized HaCaT keratinocytes and the skin of guinea pigs. METHODS: Using HaCaT cell models, the effects of salidroside on oxidative damage and possible regulatory factors [including NF-E2-related factor 2 (Nrf2), NAD(P)H-quinone oxidoreductase (NQO1), and heme oxygenase 1 (HO-1)] were examined...
September 14, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/27621703/from-traditional-resource-to-global-commodities-a-comparison-of-rhodiola-species-using-nmr-spectroscopy-metabolomics-and-hptlc
#9
Anthony Booker, Lixiang Zhai, Christina Gkouva, Shuyuan Li, Michael Heinrich
The fast developing international trade of products based on traditional knowledge and their value chains has become an important aspect of the ethnopharmacological debate. The structure and diversity of value chains and their impact on the phytochemical composition of herbal medicinal products, as well as the underlying government policies and regulations, have been overlooked in the debate about quality problems in transnational trade. Rhodiola species, including Rhodiola rosea L. and Rhodiola crenulata (Hook...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27581807/salidroside-exhibits-anti-dengue-virus-activity-by-upregulating-host-innate-immune-factors
#10
Navita Sharma, K P Mishra, Lilly Ganju
Dengue is an arboviral disease with no effective therapy available. Therefore, there is an urgent need to find a potent antiviral agent against dengue virus (DENV). In the present study, salidroside, a main bioactive compound of Rhodiola rosea, was evaluated for its antiviral potential against DENV serotype-2 infection and its effect on host innate immune factors. Antiviral effects of salidroside were examined in DENV-infected cells by western blotting, flow cytometry and real-time PCR. Its underlying mechanism involved in antiviral action was determined by evaluating expression of host innate immune factors including RIG-I, IRF-3, IRF-7, PKR, P-eIF2α and NF-κB...
December 2016: Archives of Virology
https://www.readbyqxmd.com/read/27572116/in-vitro-inhibition-of-cytochrome-p-450-activities-and-quantification-of-constituents-in-a-selection-of-commercial-rhodiola-rosea-products
#11
Ole Kristian Thu, Odd Georg Nilsen, Bent Hellum
CONTEXT: Rhodiola rosea L. (Crassulaceae) products are popular natural remedies with a worldwide distribution. Recent studies have revealed potent CYP inhibition by R. rosea extracts both in vitro and in vivo, but information on in vitro CYP inhibition by commercial products are lacking. Variations in commercial R. rosea product quality have also been published. OBJECTIVE: This study evaluates the variation of in vitro CYP inhibition potential and product quality of six commercially available R...
August 29, 2016: Pharmaceutical Biology
https://www.readbyqxmd.com/read/27517893/salidroside-suppresses-huvecs-cell-injury-induced-by-oxidative-stress-through-activating-the-nrf2-signaling-pathway
#12
Yao Zhu, Ya-Jie Zhang, Wei-Wei Liu, Ai-Wu Shi, Ning Gu
Oxidative stress plays an important role in the pathogenesis of cardiovascular diseases. Salidroside (SAL), one of the main effective constituents of Rhodiola rosea, has been reported to suppress oxidative stress-induced cardiomyocyte injury and necrosis by promoting transcription of nuclear factor E2-related factor 2 (Nrf2)-regulated genes such as heme oxygenase-1 (HO-1) and NAD(P)H dehydrogenase (quinone1) (NQO1). However, it has not been indicated whether SAL might ameliorate endothelial injury induced by oxidative stress...
2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27493875/salidroside-alleviates-cachexia-symptoms-in-mouse-models-of-cancer-cachexia-via-activating-mtor-signalling
#13
Xiangzheng Chen, Yangping Wu, Tinghan Yang, Mingtian Wei, Yuxi Wang, Xiangbing Deng, Congcong Shen, Wenting Li, Hang Zhang, Weiyong Xu, Lantu Gou, Yong Zeng, Yonghui Zhang, Ziqiang Wang, Jinliang Yang
BACKGROUND: Cachexia has a devastating impact on survival and quality of life for many cancer patients and contributes to nearly one-third of all cancer deaths; also, it is associated with poor responses to chemotherapy and survival. A better understanding of the underlying mechanisms of cancer-associated cachexia (CAC), coupled with effective therapeutic approaches, will improve management of progressive functional impairment in cancer patients. Salidroside, a phenylpropanoid glycoside in Rhodiola rosea L, has been reported to possess potential anti-fatigue, anti-ageing, and anti-Alzheimer's disease properties...
May 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27426260/effect-of-a-complex-lutein-formula-in-an-animal-model-for-light-induced-retinal-degeneration
#14
Yin-Pin Cheng, Chia-Ying Ke, Chih-Chieh Kuo, Yih-Jing Lee
Several retinal degenerative diseases cause vision loss and retinal cell death. Currently, people face prolonged exposure to digital screens, rendering vision protection from light exposure a critical topic. In this study, we designed a complex lutein formula (CLF) by combining several natural compounds: Calendula officinalis, Lycium barbarum, Vaccinium myrtillus, Cassia obtusifolia, and Rhodiola rosea. In addition, we evaluated the protective effects of the formula on retinal functions in an animal model for light-induced retinal degeneration...
August 31, 2016: Chinese Journal of Physiology
https://www.readbyqxmd.com/read/27329331/network-pharmacology-of-cancer-from-understanding-of-complex-interactomes-to-the-design-of-multi-target-specific-therapeutics-from-nature
#15
REVIEW
Paramasivan Poornima, Jothi Dinesh Kumar, Qiaoli Zhao, Martina Blunder, Thomas Efferth
Despite massive investments in drug research and development, the significant decline in the number of new drugs approved or translated to clinical use raises the question, whether single targeted drug discovery is the right approach. To combat complex systemic diseases that harbour robust biological networks such as cancer, single target intervention is proved to be ineffective. In such cases, network pharmacology approaches are highly useful, because they differ from conventional drug discovery by addressing the ability of drugs to target numerous proteins or networks involved in a disease...
September 2016: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/27271612/preventive-effects-of-rhodiola-rosea-l-on-bleomycin-induced-pulmonary-fibrosis-in-rats
#16
Ke Zhang, Xiao-Ping Si, Jian Huang, Jian Han, Xu Liang, Xiao-Bo Xu, Yi-Ting Wang, Guo-Yu Li, Hang-Yu Wang, Jin-Hui Wang
Rhodiola rosea L. (RRL) possesses a wide range of pharmacological properties, including lung-protective activity, and has been utilized in folk medicine for several 100 years. However, the lung-protective mechanism remains unclear. This study investigated the possible lung-protective activity mechanism of RRL in a pulmonary fibrosis (PF) rat model. Lung fibrotic injury was induced in Sprague-Dawley rats by single intratracheal instillation of saline containing bleomycin (BLM; 5 mg/kg). The rats were administered 125, 250, or 500 mg/kg of a 95% ethanol extract of RRL for 28 days...
2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27224273/immunmodulatory-and-antiproliferative-properties-of-rhodiola-species
#17
Mari-Carmen Recio, Rosa-María Giner, Salvador Máñez
The traditional medicines of Asia and Europe have long used various Rhodiola species, which are endemic to the subarctic areas of the northern hemisphere, as tonic, adaptogen, antidepressant, and anti-inflammatory drugs. In order to establish the therapeutic uses of these plants in modern medicine, the pharmacological effects of Rhodiola sp. have been widely studied. Indeed, the most amply researched species, Rhodiola rosea, has been shown to possess antioxidant, adaptogenic, antistress, antimicrobial, immunomodulatory, angiomodulatory, and antitumoral effects...
July 2016: Planta Medica
https://www.readbyqxmd.com/read/27214337/rhodioloside-ameliorates-depressive-behavior-via-up-regulation-of-monoaminergic-system-activity-and-anti-inflammatory-effect-in-olfactory-bulbectomized-rats
#18
Xu Zhang, Qianming Du, Chao Liu, Yan Yang, Jianing Wang, Suqian Duan, Junguo Duan
Rhodioloside, a major constituent from roots of Rhodiola rosea, has been previously confirmed to alleviate the hyperactivity in olfactory bulbectomized (OBX) rats exposed to the open field and to decrease the immobility time in the forced swimming test (FST) and tail suspension test (TST). However, its antidepressant effects and mechanisms remain unclear. This study aimed to evaluate the antidepressant effect and the potential mechanisms of rhodioloside in OBX rats. ELISA kits, HPLC-MS and western blot analysis were applied to explore the underlying antidepressant mechanisms of rhodioloside...
May 20, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27180226/neuroprotective-effects-of-p-tyrosol-after-the-global-cerebral-ischemia-in-rats
#19
Dmitriy N Atochin, Galina A Chernysheva, Vera I Smolyakova, Anton N Osipenko, Sergey V Logvinov, Anna A Zhdankina, Sergey V Sysolyatin, Yuri A Kryukov, Yana Anfinogenova, Tatiana M Plotnikova, Mark B Plotnikov
BACKGROUND: Salidroside is a biologically active compound derived from Rhodiola rosea L. Studies showed that salidroside after i.v. injection is extensively metabolized to p-tyrosol and only trace amounts of salidroside are found in the brain tissue. OBJECTIVE: The aim of the study was to investigate the neuroprotective effects of p-tyrosol in the global cerebral ischemia-reperfusion (GCI) model. STUDY DESIGN: A total of 103 Wistar rats were assigned to groups of sham-operated (n=10), control (n=42), p-tyrosol-treated (n=36), and pentoxifylline-treated (n=15) animals...
June 15, 2016: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/27176566/differential-effects-of-rhodiola-rosea-on-regulatory-t%C3%A2-cell-differentiation-and-interferon%C3%A2-%C3%AE-production-in%C3%A2-vitro-and-in%C3%A2-vivo
#20
Xi Xu, Pingping Li, Peng Zhang, Ming Chu, Hongju Liu, Xiaoping Chen, Qing Ge
Rhodiola rosea (R. rosea), a type of adaptogen, has been previously reported to exhibit immunostimulating activity in rodents and in human peripheral blood mononuclear cells (PBMCs) in vitro. To examine the effect of R. rosea on T cells under simulated microgravity, spaceflight analogs of human head‑down bed rest (HDBR) at ‑6˚ and murine hind limb unloading (HU) were used. A decrease in the levels of interferon‑γ (IFN‑γ) and interleukin‑17 (IL‑17) and an increase in regulatory T (Treg) cells were observed in the placebo group following HDBR...
July 2016: Molecular Medicine Reports
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