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Pd1 prostate

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https://www.readbyqxmd.com/read/27471580/immune-checkpoint-inhibitors-and-prostate-cancer-a-new-frontier
#1
REVIEW
Alessandra Modena, Chiara Ciccarese, Roberto Iacovelli, Matteo Brunelli, Rodolfo Montironi, Michelangelo Fiorentino, Giampaolo Tortora, Francesco Massari
Despite recent advances in the treatment of metastatic castration-resistant prostate cancer (mCRPC), agents that provide durable disease control and long-term survival are still needed. It is a fact that a tumor-induced immunosuppressive status (mediated by aberrant activation of inhibitory immune checkpoint pathways as a mechanism to evade host immune surveillance) plays a crucial role in the pathogenesis of cancer, including prostate cancer (PC), making CRPC patients suitable candidates for immunotherapy...
April 15, 2016: Oncology Reviews
https://www.readbyqxmd.com/read/25791754/biomarkers-for-immunotherapy-in-genitourinary-malignancies
#2
REVIEW
Susan F Slovin
Immunotherapy for genitourinary malignancies such as prostate, renal, and bladder cancers has experienced a resurgence since the development of 3 novel strategies: the autologous cellular product therapy, Sipuleucel-T for prostate cancer, the checkpoint inhibitors, anti-cytotoxic T-lymphocyte-associated protein 4 (anti-CTLA-4), anti-programmed cell death ligand 1 (anti-PD1), and anti-programmed cell death ligand 1), respectively. These agents have led to strikingly durable responses in several of these solid tumors, but their efficacy has been inconsistent...
April 2016: Urologic Oncology
https://www.readbyqxmd.com/read/10222154/cdna-cloning-and-characterization-of-pd1-a-novel-human-testicular-protein-with-different-expressions-in-various-testiculopathies
#3
R Graziotto, C Foresta, P Scannapieco, P Zeilante, A Russo, A Negro, R Salmaso, M Onisto
A novel human cDNA sequence has been isolated from human testis cDNA library. This sequence, named PD1, reveals an open reading frame encoding a protein of 520 amino acids. A partial sequence similarity has been found with the RBM gene involved in the regulation of human spermatogenesis. Northern blot analysis for PD1 mRNA from several human tissues demonstrated two distinct transcripts of 2.7 (more abundant) and 4.0 kb and revealed that PD1 is expressed in testis and to a lesser extent also in spleen, thymus, and prostate...
May 1, 1999: Experimental Cell Research
https://www.readbyqxmd.com/read/8826948/delayed-salvage-radiation-therapy-in-patients-with-elevated-prostate-specific-antigen-levels-after-radical-prostatectomy-a-long-term-follow-up
#4
E Medini, I Medini, P K Reddy, S H Levitt
BACKGROUND: In this article the authors report an analysis and long term results of delayed/salvage radiation therapy administered to asymptomatic patients who had an elevated prostate specific antigen (PSA) level, many months to many years after radical prostatectomy. METHODS: During 1987 to 1990, 40 asymptomatic patients were found to have an elevated PSA level 9 to 96 months after radical prostatectomy. The patients underwent transrectal needle aspiration biopsy of the urethrovesicle junction anastomosis (uvj); 28 patients had a positive biopsy and 12 patients had a negative biopsy...
September 15, 1996: Cancer
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