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https://www.readbyqxmd.com/read/29343310/effect-of-dietary-fish-oil-on-selected-inflammatory-markers-in-pigs
#1
T Komprda, P Ondráčková, M Vícenová, V Rozíková, N Procházková, L Levá, M Faldyna
The present study tested a hypothesis that dietary fish oil (eicosapentaenoic acid+docosahexaenoic acid) in a commonly achievable dose ameliorates a systemic inflammation in pigs. Two groups of pigs of 16 animals each were fed a diet with either 2.5% of fish oil (F) or a control diet with 2.5% of palm oil (P). After 70 days of fattening, eight F and eight P pigs were challenged (F+; P+) i.v. by lipopolysaccharide. After 3 h, all pigs were sacrificed and blood, liver and visceral adipose tissue (VAT) samples were taken...
January 18, 2018: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29335844/the-adiponectin-homolog-osmotin-enhances-neurite-outgrowth-and-synaptic-complexity-via-adipor1-ngr1-signaling-in-alzheimer-s-disease
#2
Gwangho Yoon, Shahid Ali Shah, Tahir Ali, Myeong Ok Kim
Alzheimer's disease is a major neurodegenerative disease characterized by memory loss and cognitive deficits. Recently, we reported that osmotin, which is a homolog of adiponectin, improved long-term potentiation and cognitive functions in Alzheimer's disease mice. Several lines of evidence have suggested that Nogo-A and the Nogo-66 receptor 1 (NgR1), which form a complex that inhibits long-term potentiation and cognitive function, might be associated with the adiponectin receptor 1 (AdipoR1), which is a receptor for osmotin...
January 15, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29330340/the-adiponectin-receptor-agonist-adiporon-ameliorates-diabetic-nephropathy-in-a-model-of-type-2-diabetes
#3
Yaeni Kim, Ji Hee Lim, Min Young Kim, Eun Nim Kim, Hye Eun Yoon, Seok Joon Shin, Bum Soon Choi, Yong-Soo Kim, Yoon Sik Chang, Cheol Whee Park
Adiponectin exerts renoprotective effects against diabetic nephropathy (DN) by activating the AMP-activated protein kinase (AMPK)/peroxisome proliferative-activated receptor-α (PPARα) pathway through adiponectin receptors (AdipoRs). AdipoRon is an orally active synthetic adiponectin receptor agonist. We investigated the expression of AdipoRs and the associated intracellular pathways in 27 patients with type 2 diabetes and examined the effects of AdipoRon on DN development in male C57BLKS/J db/db mice, glomerular endothelial cells (GECs), and podocytes...
January 12, 2018: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/29304075/%C3%AE-cell-specific-overexpression-of-adiponectin-receptor-1-does-not-improve-diabetes-mellitus-in-akita-mice
#4
Jungmi Choi, Hatasu Kobayashi, Hiroko Okuda, Kouji H Harada, Midori Takeda, Hiroyuki Fujimoto, Shunsuke Yamane, Daisuke Tanaka, Shohab Youssefian, Nobuya Inagaki, Akio Koizumi
Adiponectin, a metabolically-active cytokine secreted from adipose tissue, is reported to have anti-apoptotic effects on β-cells as well as anti-hyperglycemic effects through adiponectin receptor signaling. However, the anti-apoptotic effects of adiponectin on β-cells have not been confirmed in established diabetic models, and the anti-hyperglycemic effects and their associated signal cascades remain controversial. To investigate the effects of adiponectin on β-cell protection and its down-stream signaling events, we have generated β-cell-specific rat insulin promoter (RIP)-AdipoR1 transgenic mice (AdipoR1 mice), in which the adiponectin receptor, AdipoR1, is overexpressed in β-cells in a manner synchronous with insulin demand...
2018: PloS One
https://www.readbyqxmd.com/read/29237572/the-role-of-adipor1-and-adipor2-in-liver-fibrosis
#5
Badr Alzahrani, Tristan Iseli, Mehdi Ramezani-Moghadam, Vikki Ho, Miriam Wankell, Eun Jin Sun, Liang Qiao, Jacob George, Lionel W Hebbard
Activation of the adiponectin (APN) signaling axis retards liver fibrosis. However, understanding of the role of AdipoR1 and AdipoR2 in mediating this response is still rudimentary. Here, we sought to elucidate the APN receptor responsible for limiting liver fibrosis by employing AdipoR1 and AdipoR2 knock-out mice in the carbon tetrachloride (CCl4) model of liver fibrosis. In addition, we knocked down receptor function in primary hepatic stellate cells (HSCs) in vitro. Following the development of fibrosis, AdipoR1 and AdipoR2 KO mice had no quantitative difference in fibrosis by Sirius red staining...
December 10, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29212223/human-renal-adipose-tissue-induces-the-invasion-and-progression-of-renal-cell-carcinoma
#6
Fiorella Campo-Verde-Arbocco, José D López-Laur, Leonardo R Romeo, Noelia Giorlando, Flavia A Bruna, David E Contador, Gastón López-Fontana, Flavia E Santiano, Corina V Sasso, Leila E Zyla, Constanza M López-Fontana, Juan C Calvo, Rubén W Carón, Virginia Pistone Creydt
We evaluated the effects of conditioned media (CMs) of human adipose tissue from renal cell carcinoma located near the tumor (hRATnT) or farther away from the tumor (hRATfT), on proliferation, adhesion and migration of tumor (786-O and ACHN) and non-tumor (HK-2) human renal epithelial cell lines. Human adipose tissues were obtained from patients with renal cell carcinoma (RCC) and CMs from hRATnT and hRATfT incubation. Proliferation, adhesion and migration were quantified in 786-O, ACHN and HK-2 cell lines incubated with hRATnT-, hRATfT- or control-CMs...
November 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/29198236/acetate-alters-the-process-of-lipid-metabolism-in-rabbits
#7
C Fu, L Liu, F Li
An experiment was conducted to investigate the effect of acetate treatment on lipid metabolism in rabbits. New Zealand Rabbits (30 days, n=80) randomly received a subcutaneous injection (2 ml/injection) of 0, 0.5, 1.0 or 2.0 g/kg per day body mass acetate (dissolved in saline) for 4 days. Our results showed that acetate induced a dose-dependent decrease in shoulder adipose (P0.05), acetate treatment significantly decreased the plasma adiponectin, insulin and triglyceride concentrations (P<0.05). In adipose, acetate injection significantly up-regulated the gene expression of peroxisome proliferator-activated receptor gamma (PPARγ), CCAAT/enhancer-binding protein α (C/EBPα), differentiation-dependent factor 1 (ADD1), adipocyte protein 2 (aP2), carnitine palmitoyltransferase 1 (CPT1), CPT2, hormone-sensitive lipase (HSL), G protein-coupled receptor (GPR41), GPR43, adenosine monophosphate-activated protein kinase α1 (AMPKα1), adiponectin receptor (AdipoR1), AdipoR2 and leptin receptor...
December 4, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/29190778/mir-6835-promoted-lps-induced-inflammation-of-huvecs-associated-with-the-interaction-between-tlr-4-and-adipor1-in-lipid-rafts
#8
Jiao Liu, Guang Li, Chuang Chen, Dechang Chen, Qingshan Zhou
BACKGROUND: High mortality rate of critically-ill patients could be induced by sepsis and septic shock, which is the extremely life threatening. The purpose of this work is to identify and evaluate the potential regulatory mechanism of LPS-induced inflammation associated with miR-6835 and lipid rafts in HUVECs. METHODS: The 3' UTR luciferase activity of AdipoR1 was detected, which was predicted the potential target gene of miR-6835. Moreover, the treated HUVECs with or without inhibitors or mimics of miR-6835 were used...
2017: PloS One
https://www.readbyqxmd.com/read/29184485/globular-adiponectin-limits-microglia-pro-inflammatory-phenotype-through-an-adipor1-nf-%C3%AE%C2%BAb-signaling-pathway
#9
Sarah Nicolas, Julie Cazareth, Hadi Zarif, Alice Guyon, Catherine Heurteaux, Joëlle Chabry, Agnès Petit-Paitel
We recently reported that increased levels of Adiponectin (ApN) in the brain led to microglia phenotype and activation state regulation, thus reducing both global brain inflammation and depressive-like behaviors in mice. Apart from this, little is known on ApN molecular effects on microglia, although these cells are crucial in both physiological and pathological processes. Here we fill this gap by studying the effects and targets of ApN toward neuroinflammation. Our findings suggest that ApN deficiency in mice leads to a higher sensitivity of mice to neuroinflammation that is due to enhanced microglia responsiveness to a pro-inflammatory challenge...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29179455/lack-of-adiponectin-and-adiponectin-receptor-1-contributes-to-benign-prostatic-hyperplasia
#10
Shi Fu, Huan Xu, Meng Gu, Chong Liu, Xiang Wan, Yanbo Chen, Qi Chen, Juan Zhou, Zhong Wang
PURPOSE: The incidence of benign prostatic hyperplasia increases among obese individuals, but few studies have fully explained the underlying mechanisms. Adiponectin has drawn much attention in recent years due to its protective role in obesity-related diseases. Here we aimed to investigate the possible molecular mechanisms and clinical significance of adiponectin in relation to benign prostatic hyperplasia. METHODS: We analyzed data from 98 Chinese men, including 48 BPH cases and 50 controls in a case-control study...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29156726/adiponectin-receptor-agonists-inhibit-leptin-induced-pstat3-and-in-vivo-pancreatic-tumor-growth
#11
Fanuel Messaggio, Alisha M Mendonsa, Jason Castellanos, Nagaraj S Nagathihalli, Lee Gorden, Nipun B Merchant, Michael N VanSaun
Obesity is a significant risk factor for pancreatic cancer, harboring a chronic inflammatory condition characterized by dysregulation of the adipokines, leptin and adiponectin, that in turn alter oncogenic signaling pathways. We and others have shown that leptin promotes the proliferation and an invasive potential of pancreatic cancer cells through STAT3 mediated signaling. However, the role of adiponectin on the tumorigenicity of pancreatic cancer has not been elucidated. Adiponectin represents an important negative regulator of cytokines, which acts through two receptors, ADIPOR1 and ADIPOR2, to elicit pro-apoptotic, anti-inflammatory, and anti-angiogenic responses...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29145541/variations-in-adipor1-but-not-adipor2-are-associated-with-hypertriglyceridemia-and-diabetes-in-an-admixed-latin-american-population
#12
Gustavo Gustavo Mora-García, María S Ruiz-Díaz, Fabian Espitia-Almeida, Doris Gómez-Camargo
BACKGROUND: Adiponectin is a hormone secreted by adipose tissue. It regulates glycolysis and lipolysis and is involved in the pathophysiology of diabetes and related disorders. Its activity is mainly mediated by the transmembrane receptors AdipoR1 and AdipoR2, which are encoded by ADIPOR1 (1q32.1) and ADIPOR2 (12p13.33) genes, respectively. In genetic association studies, single nucleotide polymorphisms (SNPs) in or near these genes have been associated with metabolic alterations. However, these relationships are still controversial...
July 2017: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29138278/a-cytoplasmic-compass-is-necessary-for-cell-survival-and-triple-negative-breast-cancer-pathogenesis-by-regulating-metabolism
#13
Lu Wang, Clayton K Collings, Zibo Zhao, Kira Alia Cozzolino, Quanhong Ma, Kaiwei Liang, Stacy A Marshall, Christie C Sze, Rintaro Hashizume, Jeffrey Nicholas Savas, Ali Shilatifard
Mutations and translocations within the COMPASS (complex of proteins associated with Set1) family of histone lysine methyltransferases are associated with a large number of human diseases, including cancer. Here we report that SET1B/COMPASS, which is essential for cell survival, surprisingly has a cytoplasmic variant. SET1B, but not its SET domain, is critical for maintaining cell viability, indicating a novel catalytic-independent role of SET1B/COMPASS. Loss of SET1B or its unique cytoplasmic-interacting protein, BOD1, leads to up-regulation of expression of numerous genes modulating fatty acid metabolism, including ADIPOR1 (adiponectin receptor 1), COX7C, SDC4, and COQ7 Our detailed molecular studies identify ADIPOR1 signaling, which is inactivated in both obesity and human cancers, as a key target of SET1B/COMPASS...
November 14, 2017: Genes & Development
https://www.readbyqxmd.com/read/29115432/adiponectin-and-its-receptors-are-involved-in-hypertensive-vascular-injury
#14
Ruimin Guo, Min Han, Juan Song, Jun Liu, Yanni Sun
Adipocyte-derived adiponectin (APN) is involved in the protection against cardiovascular disease, but the endogenous APN and its receptor expression in the perivascular adipocytes and their role in hypertensive vascular injury remain unclear. The present study aimed to detect endogenous APN and its receptor expression and their protective effects against hypertensive vascular injury. APN was mainly expressed in the perivascular adipocytes, while its receptors AdipoR1 and AdipoR2 were ubiquitously expressed in the blood vessels...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29105398/oral-quercetin-supplementation-enhances-adiponectin-receptor-transcript-expression-in-polycystic-ovary-syndrome-patients-a-randomized-placebo-controlled-double-blind-clinical-trial
#15
Neda Rezvan, Ashraf Moini, Sattar Gorgani-Firuzjaee, Mohammad Javad Hosseinzadeh-Attar
OBJECTIVES: Polycystic ovary syndrome (PCOS), an ovarian-pituitary axis androgen disorder, is a common endocrine disease in women. Obesity-induced androgenesis and imbalance of adipokine secretion may lead to some metabolic features of PCOS. The beneficial effects of polyphenolic compounds such as quercetin have been reported, however, the underlying molecular mechanism is not entirely understood. In the present study, we investigated the effect of quercetin supplementation on the expression of adiponectin receptors at the transcript level in peripheral blood mononuclear cells (PBMC) samples of PCOS patients...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29073286/differential-adipokine-receptor-expression-on-circulating-leukocyte-subsets-in-lean-and-obese-children
#16
Genoveva Keustermans, Laila B van der Heijden, Berlinda Boer, Rianne Scholman, Roos Nuboer, Gerard Pasterkamp, Berent Prakken, Wilco de Jager, Eric Kalkhoven, Arieke J Janse, Henk S Schipper
BACKGROUND: Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far...
2017: PloS One
https://www.readbyqxmd.com/read/29022894/adiponectin-controls-the-apoptosis-and-the-expression-of-tight-junction-proteins-in-brain-endothelial-cells-through-adipor1-under-beta-amyloid-toxicity
#17
Juhyun Song, Seong-Min Choi, Daniel J Whitcomb, Byeong C Kim
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by excessive beta amyloid (Aβ) deposition in brain, leading to blood-brain barrier (BBB) disruption. The mechanisms of BBB disruption in AD are still unclear, despite considerable research. The adipokine adiponectin is known to regulate various metabolic functions and reduce inflammation. Though adiponectin receptors have been reported in the brain, its role in the central nervous system has not been fully characterized. In the present study, we investigate whether adiponectin contributes to the tight junction integrity and cell death of brain endothelial cells under Aβ-induced toxicity conditions...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28993734/osmotin-protects-h9c2-cells-from-simulated-ischemia-reperfusion-injury-through-adipor1-pi3k-akt-signaling-pathway
#18
Jianhua Liu, Hua Sui, Jianlin Zhao, Yan Wang
Objective: This study aimed to investigate the effect of osmotin on myocardial ischemia/reperfusion (I/R), as well as the underlying mechanisms. Methods:In vitro I/R injury model was established on rat cardiac myoblast H9c2 cells by oxygen and glucose deprivation followed by reperfusion (OGD/R). Cells were administrated with osmotin, and transfected with small interfering RNAs (siRNAs) which specifically target adiponectin receptor 1 or 2 (AdipoR1/2). Besides, the cells were incubated with or without LY294002 as inhibitor of phosphatidylinositol 3-kinase (PI3K) under OGD/R condition...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28982654/erratum-pathophysiological-mechanism-of-bone-loss-in-type-2-diabetes-involves-inverse-regulation-of-osteoblast-function-by-pgc-1%C3%AE-and-skeletal-muscle-atrogenes-adipor1-as-a-potential-target-for-reversing-diabetes-induced-osteopenia-diabetes-2015-64-2609-2623
#19
Mohd Parvez Khan, Abhishek Kumar Singh, Amit Arvind Joharapurkar, Manisha Yadav, Sonal Shree, Harish Kumar, Anagha Gurjar, Jay Sharan Mishra, Mahesh Chandra Tiwari, Geet Kumar Nagar, Sudhir Kumar, Ravishankar Ramachandran, Anupam Sharan, Mukul Rameshchandra Jain, Arun Kumar Trivedi, Rakesh Maurya, Madan Madhav Godbole, Jiaur Rahaman Gayen, Sabyasachi Sanyal, Naibedya Chattopadhyay
No abstract text is available yet for this article.
October 5, 2017: Diabetes
https://www.readbyqxmd.com/read/28974704/maternal-intake-of-grape-seed-procyanidins-during-lactation-induces-insulin-resistance-and-an-adiponectin-resistance-like-phenotype-in-rat-offspring
#20
Antoni Caimari, Roger Mariné-Casadó, Noemí Boqué, Anna Crescenti, Lluís Arola, Josep Maria Del Bas
Previously, we demonstrated that a grape seed procyanidin extract (GSPE) supplementation in pregnant and lactating rats exerted both healthy and deleterious programming effects on their offspring. Here, we evaluated whether the administration of GSPE during lactation (100 mg.kg(-1).day(-1)) in rats elicited beneficial effects in their normoweight (STD-GSPE group) and cafeteria-fed obese (CAF-GSPE group) adult male offspring. STD-GSPE and CAF-GSPE offspring showed increased energy expenditure and circulating total and high-molecular-weight adiponectin...
October 3, 2017: Scientific Reports
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