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https://www.readbyqxmd.com/read/28338883/the-effects-of-oleanolic-acid-on-atherosclerosis-in-different-animal-models
#1
Hanqiong Luo, Jine Liu, Qiong Ouyang, Chunxiao Xuan, Lanlan Wang, Tingting Li, Jun Liu
In the present study, three animal models, including C57BL/6J mice, low-density lipoprotein receptor knockout (LDLR-/-) mice, and rabbit that mimicked atherosclerosis, were established to investigate the inhibitory effect of oleanolic acid (OA) on atherosclerosis. In rabbit model, serum total cholesterol (TC), triglyceride, low density lipoprotein cholesterol (LDL-C), and high density lipoprotein cholesterol (HDL-C) were measured. Carotid artery lesions were isolated for histological analysis. The red oil O and hematoxylin-eosin staining in liver were examined...
March 4, 2017: Acta Biochimica et Biophysica Sinica
https://www.readbyqxmd.com/read/28330882/adiponectin-and-resistin-a-role-in-the-hypothalamo-pituitary-gonadal-axis
#2
Agnieszka Rak, Namya Mellouk, Pascal Froment, Joëlle Dupont
Adipokines, including adiponectin and resistin, are cytokines produced mainly by adipose tissue. They play a significant role in the metabolic functions that regulate insulin sensitivity and inflammation. Alteration of adiponectin and resistin plasma levels, or their expression in metabolic and gonadal tissue, are observed in some metabolic pathologies, such as obesity. Several studies have shown that these two hormones and the receptors for adiponectin, AdipoR1 and AdipoR2, are present in various reproductive tissues in both sexes of different species...
March 22, 2017: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/28329765/structural-insights-into-adiponectin-receptors-suggest-ceramidase-activity
#3
Ieva Vasiliauskaité-Brooks, Remy Sounier, Pascal Rochaix, Gaëtan Bellot, Mathieu Fortier, François Hoh, Luigi De Colibus, Chérine Bechara, Essa M Saied, Christoph Arenz, Cédric Leyrat, Sébastien Granier
Adiponectin receptors (ADIPORs) are integral membrane proteins that control glucose and lipid metabolism by mediating, at least in part, a cellular ceramidase activity that catalyses the hydrolysis of ceramide to produce sphingosine and a free fatty acid (FFA). The crystal structures of the two receptor subtypes, ADIPOR1 and ADIPOR2, show a similar overall seven-transmembrane-domain architecture with large unoccupied cavities and a zinc binding site within the seven transmembrane domain. However, the molecular mechanisms by which ADIPORs function are not known...
March 22, 2017: Nature
https://www.readbyqxmd.com/read/28327197/lipid-raft-mediated-mir-3908-inhibition-of-migration-of-breast-cancer-cell-line-mcf-7-by-regulating-the-interactions-between-adipor1-and-flotillin-1
#4
Yuan Li, Fei Shan, Jinglong Chen
BACKGROUND: The mechanisms of lipid raft regulation by microRNAs in breast cancer are not fully understood. This work focused on the evaluation and identification of miR-3908, which may be a potential biomarker related to the migration of breast cancer cells, and elucidates lipid-raft-regulating cell migration in breast cancer. METHODS: To confirm the prediction that miR-3908 is matched with AdipoR1, we used 3'-UTR luciferase activity of AdipoR1 to assess this. Then, human breast cancer cell line MCF-7 was cultured in the absence or presence of the mimics or inhibitors of miR-3908, after which the biological functions of MCF-7 cells were analyzed...
March 21, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28293385/adiporon-may-be-benefit-for-atherosclerosis-prevention
#5
EDITORIAL
Maryam Esfahani, Nooshin Shabab, Massoud Saidijam
Atherosclerosis has serious role in coronary arteries disease, so it is important to establish effective strategies for prevention or even treatment of atherosclerosis. Adiponectin, as one of the most abundant adipokines, has insulin sensitivity, anti-inflammatory and anti-atherogenic properties. Disturbed adiponectin actions through its receptor, (AdipoR1 and AdipoR2) may be involved in atherosclerosis development. Some adiponectin effects are mediated by AMPK and PPAR-α signaling. AdipoRon is an orally active synthetic molecule which can bind to AdipoR1, Adipo R2 and activate them...
February 2017: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/28288470/circulating-concentrations-of-adipocytokines-and-their-receptors-in-the-isolated-corpus-cavernosum-and-femoral-artery-from-trained-rats-on-a-high-fat-diet
#6
Amanda C S Sponton, Fábio H Silva, Hygor N Araujo, Carmem P Valgas da Silva, Camila de Moraes, Edson Antunes, Angelina Zanesco, Maria A Delbin
BACKGROUND: The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. METHODS: Functional experiments were performed in control sedentary and trained rats, and sedentary (h-SD) and trained male Wistar rats on a high-fat diet (h-TR)...
March 14, 2017: Journal of Vascular Research
https://www.readbyqxmd.com/read/28285359/globular-adiponectin-inhibits-leptin-stimulated-esophageal-adenocarcinoma-cell-proliferation-via-adiponectin-receptor-2-mediated-suppression-of-uhrf1
#7
Jun Wang, Yan Cheng, Xiaoran Yin, Jie Wu, Yumei Luo, Jing Wu, Jia Di, Dong Liu, Yahui Huang, Rong Zhang, Jun Zhang
Esophageal adenocarcinoma (EAC) is one of the most common malignancies in the world which is associated the increased prevalence of obesity. In the context of obesity, leptin can directly contribute to progression of EAC. Adiponectin inhibits leptin-induced oncogenic signaling in EAC cells. However, the exact molecular mechanisms linking obesity, adipokines, and EAC remain far from completely understood. In the present study, we tested the role of ubiquitin-like with PHD and ring finger domains 1 (UHRF1) in adiponectin-induced protective effects against leptin-induced EAC cell proliferation...
March 11, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28271033/inducible-overexpression-of-adiponectin-receptors-highlight-the-roles-of-adiponectin-induced-ceramidase-signaling-in-lipid-and-glucose-homeostasis
#8
William L Holland, Jonathan Y Xia, Joshua A Johnson, Kai Sun, Mackenzie J Pearson, Ankit X Sharma, Ezekiel Quittner-Strom, Trevor S Tippetts, Ruth Gordillo, Philipp E Scherer
OBJECTIVE: Adiponectin and the signaling induced by its cognate receptors, AdipoR1 and AdipoR2, have garnered attention for their ability to promote insulin sensitivity and oppose steatosis. Activation of these receptors promotes the deacylation of ceramide, a lipid metabolite that appears to play a causal role in impairing insulin signaling. METHODS: Here, we have developed transgenic mice that overexpress AdipoR1 or AdipoR2 under the inducible control of a tetracycline response element...
March 2017: Molecular Metabolism
https://www.readbyqxmd.com/read/28262215/aerobic-exercise-suppresses-atherosclerosis-through-adiponectin-nuclear-transcription-factor-%C3%AE%C2%BAb-pathway-in-apolipoprotein-e-deficient-mice
#9
Weidong Wu, Haiying Wang, Guangfa Jiao, Jingjing Yue, Guowei Wang
BACKGROUND: We aimed to investigate the therapeutic effect of aerobic exercise on atherosclerosis (AS) in apolipoprotein E-deficient mice and the adiponectin (ApN)-nuclear transcription factor κB (NF-κB) pathway involved in the related anti-inflammation. MATERIALS AND METHODS: ApoE-deficient mice with AS (AS+C), and ApoE-deficient mice with AS and aerobic exercise (AS+E) were investigated for body weight and visceral fat. Pathomorphology of the aortic vascular wall was qualitatively and quantitatively evaluated with hematoxylin-eosin staining...
March 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28260395/a-potent-peptide-as-adiponectin-receptor-1-agonist-to-against-fibrosis
#10
Lingman Ma, Zhen Zhang, Xiaowen Xue, Yumeng Wan, Boping Ye, Kejiang Lin
Fibrotic diseases have become a major cause of death in the developed world. AdipoR1 agonists are potent inhibitors of fibrotic responses. Here, we focused on the in silico identification of novel AdipoR1 peptide agonists. A homology model was constructed to predict the 3D structure of AdipoR1. By docking to known active peptides, the putative active site of the model was further explored. A virtual screening study was then carried out with a set of manually designed peptides using molecular docking. Peptides with high docking scores were then evaluated for their anti-fibrotic properties...
December 2017: Journal of Enzyme Inhibition and Medicinal Chemistry
https://www.readbyqxmd.com/read/28258256/decreased-adiponectin-mediated-signaling-through-the-adipor2-pathway-is-associated-with-carotid-plaque-instability
#11
Karina Gasbarrino, Huaien Zheng, Anouar Hafiane, John P Veinot, Chi Lai, Stella S Daskalopoulou
BACKGROUND AND PURPOSE: Adiponectin, the most abundantly secreted anti-inflammatory adipokine, protects against all stages of atherosclerotic plaque formation by acting on its receptors, AdipoR1 (adiponectin receptor 1) and AdipoR2 (adiponectin receptor 2). Through binding of AdipoR1, adiponectin leads to the activation of the AMPK (adenosine monophosphate-activated protein kinase) pathway, whereas stimulation of PPAR-α (peroxisome proliferator-activated receptor-α) is attributed to the binding of AdipoR2...
March 3, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28258220/adiponectin-confers-protection-from-acute-colitis-and-restricts-a-b-cell-immune-response
#12
Stephanie Obeid, Miriam Wankell, Berenice Charrez, Jade Sternberg, Roxane Kreuter, Saeed Esmaili, Mehdi Ramezani-Moghadam, Carol Devine, Scott Read, Prithi Bhathal, Andreas Lopata, Golo Ahlenstiel, Liang Qiao, Jacob George, Lionel Hebbard
Adiponectin demonstrates beneficial effects in various metabolic diseases including diabetes, and in bowel cancer. Recent data also suggests a protective role in colitis. However, the precise molecular mechanisms by which adiponectin and its receptors modulate colitis and the nature of the adaptive immune response in murine models are yet to be elucidated. Adiponectin-knockout mice were orally administered dextran sulfate sodium for 7 days, and were compared to wild-type mice. The severity of disease was analysed histopathologically, and through cytokine profiling...
March 3, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28195643/a-prospective-evaluation-of-clinical-and-genetic-predictors-of-weight-changes-in-breast-cancer-survivors
#13
Maureen Sadim, Yanfei Xu, Katharina Selig, Julie Paulus, Regina Uthe, Surbhi Agarwl, Iram Dubin, Panagiota Oikonomopoulou, Lesya Zaichenko, Silvia Aki McCandlish, Linda Van Horn, Christos Mantzoros, Donna Pauler Ankerst, Virginia G Kaklamani
BACKGROUND: Postdiagnosis weight gain in patients with breast cancer has been associated with increased cancer recurrence and mortality. This study was designed to identify risk factors for weight gain and create a predictive model to identify a high-risk population for targeted interventions. METHODS: The weight of 393 patients with breast cancer from the Northwestern Robert H. Lurie Cancer Center was measured over a 2-year period from diagnosis, with body mass index (BMI) change over 18 months as the primary endpoint...
February 14, 2017: Cancer
https://www.readbyqxmd.com/read/28188344/skeletal-muscle-secretome-in-duchenne-muscular-dystrophy-a-pivotal-anti-inflammatory-role-of-adiponectin
#14
S Lecompte, M Abou-Samra, R Boursereau, L Noel, S M Brichard
BACKGROUND: Persistent inflammation exacerbates the progression of Duchenne muscular dystrophy (DMD). The hormone, adiponectin (ApN), which is decreased in the metabolic syndrome, exhibits anti-inflammatory properties on skeletal muscle and alleviates the dystrophic phenotype of mdx mice. Here, we investigate whether ApN retains its anti-inflammatory action in myotubes obtained from DMD patients. We unravel the underlying mechanisms by studying the secretome and the early events of ApN...
February 10, 2017: Cellular and Molecular Life Sciences: CMLS
https://www.readbyqxmd.com/read/28183249/adiponectin-as-a-potential-therapeutic-target-for-prostate-cancer
#15
Hanuma Kumar Karnati, Manas Kumar Panigrahi, Yazhou Li, David Tweedie, Nigel H Greig
Adipokines are bioactive proteins that mediate proliferation, metabolism, inflammation, and angiogenesis. Adiponectin is an important adipokine that exerts multiple key functions via its anti-metabolic syndrome and anti-inflammatory properties. A number of adiponectin receptors, AdipoR1, AdipoR2 and T-cadherin, have been identified. Recent studies have suggested the involvement of adiponectin and receptors in several cancers, including prostate, breast, endometrial, brain, and colon cancer. Altered levels of adiponectin expression, or its interacting receptors, in cancers can lead to dysregulation of signaling pathways...
February 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28178338/the-impact-of-obesity-and-adiponectin-signaling-in-patients-with-renal-cell-carcinoma-a-potential-mechanism-for-the-obesity-paradox
#16
Ryuichi Ito, Shintaro Narita, Mingguo Huang, Taketoshi Nara, Kazuyuki Numakura, Koichiro Takayama, Hiroshi Tsuruta, Atsushi Maeno, Mitsuru Saito, Takamitsu Inoue, Norihiko Tsuchiya, Shigeru Satoh, Tomonori Habuchi
Although obesity increases the risk of renal cell carcinoma (RCC), obese patients with RCC experience longer survival than non-obese patients. However, the mechanism of this "obesity paradox" is unknown. We examined the impact of preoperative BMI, serum total adiponectin (sAd) level, total adiponectin secretion from perinephric adipose tissue, and intratumoral expression of adiponectin receptors on RCC aggressiveness and survival. We also investigated the mechanism underlying enhanced cancer aggressiveness in RCC cells stimulated with exogenous adiponectin...
2017: PloS One
https://www.readbyqxmd.com/read/28177362/effect-of-progesterone-on-adiponectin-system-in-the-porcine-uterus-during-early-pregnancy
#17
K Dobrzyn, N Smolinska, K Szeszko, M Kiezun, A Maleszka, E Rytelewska, T Kaminski
The aim of this study was to investigate the influence of progesterone (P4) on adiponectin system genes and protein expression in the endometrium and myometrium during early gestation. Twenty-five gilts were assigned to 1 of 5 groups ( = 5): d 10 to 11 (embryo migration), 12 to 13 (maternal recognition of pregnancy), 15 to 16 (implantation), and 27 to 28 (end of implantation) of pregnancy and d 10 to 11 of the cycle (fully active corpora lutea, corresponding to the corpora lutea activity during gestation). The endometrial and myometrial tissues were cut into 100 mg slices, treated with P4 (10, 100, 1000 nM) and incubated for 24 h...
January 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28145500/muscle-specific-overexpression-of-adipor1-or-adipor2-gives-rise-to-common-and-discrete-local-effects-whilst-adipor2-promotes-additional-systemic-effects
#18
Sahar Keshvari, Darren C Henstridge, Choaping Ng, Mark A Febbraio, Jonathan P Whitehead
Hypoadiponectinemia and adiponectin resistance are implicated in the aetiology of obesity-related cardiometabolic disorders, hence represent a potential therapeutic axis. Here we characterised the effects of in vivo electrotransfer-mediated overexpression of the adiponectin receptors, AdipoR1 or AdipoR2, into tibialis anterior muscle (TAM) of lean or obese mice. In lean mice, TAM-specific overexpression of AdipoR1 ((TAM)R1) or AdipoR2 ((TAM)R2) increased phosphorylation of AMPK, AKT and ERK and expression of the insulin responsive glucose transporter glut4...
February 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28115224/the-burden-of-obesity-in-asthma-and-copd-role-of-adiponectin
#19
REVIEW
Andrea Bianco, Ersilia Nigro, Maria Ludovica Monaco, Maria Gabriella Matera, Olga Scudiero, Gennaro Mazzarella, Aurora Daniele
The influence of obesity on development, severity and prognosis of both asthma and COPD is attracting growing interest. The impact of obesity on the respiratory system ranges from structural modifications (decline of total lung capacity) to humoral alterations. Adipose tissue strongly contributes to the establishment of an inflammatory state being an important source of adipokines. Amongst adipokines, adiponectin is an important component of organ cross talk with adipose tissue exerting protective effects on a variety of pathophysiological processes...
January 20, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28063235/a-critical-role-for-adiponectin-mediated-development-of-endometrial-luminal-epithelial-cells-during-the-peri-implantation-period-of-pregnancy
#20
Whasun Lim, Myung Jin Choi, Hyocheol Bae, Fuller W Bazer, Gwonhwa Song
Adiponectin is one of the adipokines in the collagen superfamily. It is secreted primarily by white adipocytes and influences reproductive processes including ovarian and uterine functions. Adiponectin regulates energy homeostasis, insulin sensitivity and is anti-inflammatory in various tissues. Its receptors (ADIPOR1 and ADIPOR2) are widely expressed in mammalian tissues, including porcine conceptuses and endometrial during the estrous cycle and peri-implantation period of pregnancy. However, regulatory effects of adiponectin on endometrial epithelial cells are unknown...
January 7, 2017: Journal of Cellular Physiology
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