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https://www.readbyqxmd.com/read/29145541/variations-in-adipor1-but-not-adipor2-are-associated-with-hypertriglyceridemia-and-diabetes-in-an-admixed-latin-american-population
#1
Gustavo Gustavo Mora-García, María S Ruiz-Díaz, Fabian Espitia-Almeida, Doris Gómez-Camargo
BACKGROUND: Adiponectin is a hormone secreted by adipose tissue. It regulates glycolysis and lipolysis and is involved in the pathophysiology of diabetes and related disorders. Its activity is mainly mediated by the transmembrane receptors AdipoR1 and AdipoR2, which are encoded by ADIPOR1 (1q32.1) and ADIPOR2 (12p13.33) genes, respectively. In genetic association studies, single nucleotide polymorphisms (SNPs) in or near these genes have been associated with metabolic alterations. However, these relationships are still controversial...
July 2017: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29138278/a-cytoplasmic-compass-is-necessary-for-cell-survival-and-triple-negative-breast-cancer-pathogenesis-by-regulating-metabolism
#2
Lu Wang, Clayton K Collings, Zibo Zhao, Kira Alia Cozzolino, Quanhong Ma, Kaiwei Liang, Stacy A Marshall, Christie C Sze, Rintaro Hashizume, Jeffrey Nicholas Savas, Ali Shilatifard
Mutations and translocations within the COMPASS (complex of proteins associated with Set1) family of histone lysine methyltransferases are associated with a large number of human diseases, including cancer. Here we report that SET1B/COMPASS, which is essential for cell survival, surprisingly has a cytoplasmic variant. SET1B, but not its SET domain, is critical for maintaining cell viability, indicating a novel catalytic-independent role of SET1B/COMPASS. Loss of SET1B or its unique cytoplasmic-interacting protein, BOD1, leads to up-regulation of expression of numerous genes modulating fatty acid metabolism, including ADIPOR1 (adiponectin receptor 1), COX7C, SDC4, and COQ7 Our detailed molecular studies identify ADIPOR1 signaling, which is inactivated in both obesity and human cancers, as a key target of SET1B/COMPASS...
November 14, 2017: Genes & Development
https://www.readbyqxmd.com/read/29115432/adiponectin-and-its-receptors-are-involved-in-hypertensive-vascular-injury
#3
Ruimin Guo, Min Han, Juan Song, Jun Liu, Yanni Sun
Adipocyte-derived adiponectin (APN) is involved in the protection against cardiovascular disease, but the endogenous APN and its receptor expression in the perivascular adipocytes and their role in hypertensive vascular injury remain unclear. The present study aimed to detect endogenous APN and its receptor expression and their protective effects against hypertensive vascular injury. APN was mainly expressed in the perivascular adipocytes, while its receptors AdipoR1 and AdipoR2 were ubiquitously expressed in the blood vessels...
October 25, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29105398/oral-quercetin-supplementation-enhances-adiponectin-receptor-transcript-expression-in-polycystic-ovary-syndrome-patients-a-randomized-placebo-controlled-double-blind-clinical-trial
#4
Neda Rezvan, Ashraf Moini, Sattar Gorgani-Firuzjaee, Mohammad Javad Hosseinzadeh-Attar
OBJECTIVES: Polycystic ovary syndrome (PCOS), an ovarian-pituitary axis androgen disorder, is a common endocrine disease in women. Obesity-induced androgenesis and imbalance of adipokine secretion may lead to some metabolic features of PCOS. The beneficial effects of polyphenolic compounds such as quercetin have been reported, however, the underlying molecular mechanism is not entirely understood. In the present study, we investigated the effect of quercetin supplementation on the expression of adiponectin receptors at the transcript level in peripheral blood mononuclear cells (PBMC) samples of PCOS patients...
January 2018: Cell Journal
https://www.readbyqxmd.com/read/29073286/differential-adipokine-receptor-expression-on-circulating-leukocyte-subsets-in-lean-and-obese-children
#5
Genoveva Keustermans, Laila B van der Heijden, Berlinda Boer, Rianne Scholman, Roos Nuboer, Gerard Pasterkamp, Berent Prakken, Wilco de Jager, Eric Kalkhoven, Arieke J Janse, Henk S Schipper
BACKGROUND: Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far...
2017: PloS One
https://www.readbyqxmd.com/read/29022894/adiponectin-controls-the-apoptosis-and-the-expression-of-tight-junction-proteins-in-brain-endothelial-cells-through-adipor1-under-beta-amyloid-toxicity
#6
Juhyun Song, Seong-Min Choi, Daniel J Whitcomb, Byeong C Kim
Alzheimer's disease (AD) is the most common neurodegenerative disease, characterized by excessive beta amyloid (Aβ) deposition in brain, leading to blood-brain barrier (BBB) disruption. The mechanisms of BBB disruption in AD are still unclear, despite considerable research. The adipokine adiponectin is known to regulate various metabolic functions and reduce inflammation. Though adiponectin receptors have been reported in the brain, its role in the central nervous system has not been fully characterized. In the present study, we investigate whether adiponectin contributes to the tight junction integrity and cell death of brain endothelial cells under Aβ-induced toxicity conditions...
October 12, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28993734/osmotin-protects-h9c2-cells-from-simulated-ischemia-reperfusion-injury-through-adipor1-pi3k-akt-signaling-pathway
#7
Jianhua Liu, Hua Sui, Jianlin Zhao, Yan Wang
Objective: This study aimed to investigate the effect of osmotin on myocardial ischemia/reperfusion (I/R), as well as the underlying mechanisms. Methods:In vitro I/R injury model was established on rat cardiac myoblast H9c2 cells by oxygen and glucose deprivation followed by reperfusion (OGD/R). Cells were administrated with osmotin, and transfected with small interfering RNAs (siRNAs) which specifically target adiponectin receptor 1 or 2 (AdipoR1/2). Besides, the cells were incubated with or without LY294002 as inhibitor of phosphatidylinositol 3-kinase (PI3K) under OGD/R condition...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28982654/erratum-pathophysiological-mechanism-of-bone-loss-in-type-2-diabetes-involves-inverse-regulation-of-osteoblast-function-by-pgc-1%C3%AE-and-skeletal-muscle-atrogenes-adipor1-as-a-potential-target-for-reversing-diabetes-induced-osteopenia-diabetes-2015-64-2609-2623
#8
Mohd Parvez Khan, Abhishek Kumar Singh, Amit Arvind Joharapurkar, Manisha Yadav, Sonal Shree, Harish Kumar, Anagha Gurjar, Jay Sharan Mishra, Mahesh Chandra Tiwari, Geet Kumar Nagar, Sudhir Kumar, Ravishankar Ramachandran, Anupam Sharan, Mukul Rameshchandra Jain, Arun Kumar Trivedi, Rakesh Maurya, Madan Madhav Godbole, Jiaur Rahaman Gayen, Sabyasachi Sanyal, Naibedya Chattopadhyay
No abstract text is available yet for this article.
October 5, 2017: Diabetes
https://www.readbyqxmd.com/read/28974704/maternal-intake-of-grape-seed-procyanidins-during-lactation-induces-insulin-resistance-and-an-adiponectin-resistance-like-phenotype-in-rat-offspring
#9
Antoni Caimari, Roger Mariné-Casadó, Noemí Boqué, Anna Crescenti, Lluís Arola, Josep Maria Del Bas
Previously, we demonstrated that a grape seed procyanidin extract (GSPE) supplementation in pregnant and lactating rats exerted both healthy and deleterious programming effects on their offspring. Here, we evaluated whether the administration of GSPE during lactation (100 mg.kg(-1).day(-1)) in rats elicited beneficial effects in their normoweight (STD-GSPE group) and cafeteria-fed obese (CAF-GSPE group) adult male offspring. STD-GSPE and CAF-GSPE offspring showed increased energy expenditure and circulating total and high-molecular-weight adiponectin...
October 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28963462/suppression-of-adiponectin-receptor-1-promotes-memory-dysfunction-and-alzheimer-s-disease-like-pathologies
#10
Min Woo Kim, Noman Bin Abid, Myeong Hoon Jo, Min Gi Jo, Gwang Ho Yoon, Myeong Ok Kim
Recent studies on neurodegeneration have focused on dysfunction of CNS energy metabolism as well as proteinopathies. Adiponectin (ADPN), an adipocyte-derived hormone, plays a major role in the regulation of insulin sensitivity and glucose homeostasis in peripheral organs via adiponectin receptors. In spite of accumulating evidence that adiponectin has neuroprotective properties, the underlying role of adiponectin receptors has not been illuminated. Here, using gene therapy-mediated suppression with shRNA, we found that adiponectin receptor 1 (AdipoR1) suppression induces neurodegeneration as well as metabolic dysfunction...
September 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28952262/-piperine-regulates-glucose-metabolism-disorder-in-hepg2-cells-of-insulin-resistance-models-via-targeting-upstream-target-of-ampk-signaling-pathway
#11
Chun-Ping Wan, Ya-Gai Wei, Xiao-Xue Li, Li-Jun Zhang, Rui Yang, Zhao-Ri-Ge-Tu Bao
To investigate the effect of piperine on the disorder of glucose metabolism in the cell model with insulin resistance (IR) and explore the molecules mechanism on intervening the upstream target of AMPK signaling pathway. The insulin resistance models in HepG2 cells were established by fat emulsion stimulation. Then glucose consumption in culture supernatant was detected by GOD-POD method. Enzyme-linked immunosorbent assay(ELISA) was used to measure the levels of leptin(LEP) and adiponectin(APN) in culture supernatant; Real-time quantitative PCR was used to assess the mRNA expression of APN and LEP; and the protein expression levels of LepR, AdipoR1, AdipoR2 and the activation of AMPK signaling pathway were detected by Western blot analysis...
February 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/28946816/effect-of-tnf-%C3%AE-on-molecules-related-to-the-insulin-action-in-endometrial-cells-exposed-to-hyperandrogenic-and-hyperinsulinic-conditions-characteristics-of-polycystic-ovary-syndrome
#12
Lorena Oróstica, Paula García, Carolina Vera, Víctor García, Carmen Romero, Margarita Vega
Polycystic ovary syndrome (PCOS) affects not only ovarian functions but is also able to affect endometrium metabolism. Around 80% of women with PCOS are obese. High tumor necrosis factor (TNF)-α production and low adiponectin levels are characteristics of obesity. Interestingly, endometrium from obese women with PCOS presents an insulin-resistance condition, high TNF-α levels, and low adiponectin levels. However, TNF-α effect on molecules associated with insulin action in endometrial cells remains unclear...
January 1, 2017: Reproductive Sciences
https://www.readbyqxmd.com/read/28940978/effects-of-short-term-add-on-ezetimibe-to-statin-treatment-on-expression-of-adipokines-and-inflammatory-markers-in-diabetic-and-dyslipidemic-patients
#13
Elizandra Silva Guimarães, Alvaro Cerda, Egidio Lima Dorea, Marcia Martins Silveira Bernik, Maria Cecilia Gusukuma, Gelba Almeida Pinto, Cristina Moreno Fajardo, Mario Hiroyuki Hirata, Rosario Dominguez Crespo Hirata
AIM: The influence of short-term add-on ezetimibe to simvastatin treatment on expression of adipokines and inflammatory markers was investigated in diabetic and nondiabetic patients with hypercholesterolemia. METHOD: Hypercholesterolemic nondiabetic (HC, n = 37) and diabetic (DM, n = 47) patients were treated with simvastatin (SV, 10 or 20 mg/d/8-wk) and then SV plus ezetimibe (SV + EZ, 10 mg each/d/4 wk). Serum lipids, glycemic profile, and inflammatory markers (hsCRP, adiponectin, resistin, VCAM-1, and ICAM-1) were evaluated before and after the add-on ezetimibe therapy...
September 21, 2017: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/28873415/proliferative-endocrine-effects-of-adipose-tissue-from-obese-animals-on-mcf7-cells-are-ameliorated-by-resveratrol-supplementation
#14
Christopher F Theriau, O'Llenecia S Sauvé, Marie-Soleil Beaudoin, David C Wright, Michael K Connor
Obesity is clearly associated with an increased risk of breast cancer in postmenopausal women. The purpose was to determine if obesity alters the adipocyte adipokine secretion profile, thereby altering the adipose-dependent paracrine/endocrine growth microenvironment surrounding breast cancer cells (MCF7). Additionally, we determined whether resveratrol (RSV) supplementation can counteract any obesity-dependent effects on breast cancer tumor growth microenvironment. Obese ZDF rats received standard chow diet or diet supplemented with 200 mg/kg body weight RSV...
2017: PloS One
https://www.readbyqxmd.com/read/28870804/high-glucose-instigates-tubulointerstitial-injury-by-stimulating-hetero-dimerization-of-adiponectin-and-angiotensin-ii-receptors
#15
Dongqing Zha, Huaiyan Cheng, Weiwei Li, Yizhe Wu, Xiaoning Li, Lian Zhang, Ying-Hong Feng, Xiaoyan Wu
Abnormal expression and dysfunction of adiponectin and the cognate receptors are involved in diabetes and diabetic kidney disease (DKD), whereas angiotensin receptor blockers (ARBs) and angiotensin-converting enzyme inhibitors (ACEIs) alleviate diabetic albuminuria and prevent development of DKD through upregulation of adiponectin expression. Here we report that high glucose stimulates expression of angiotensin II (AngII) receptors (AT1 and AT2) in renal proximal tubular epithelial cells (NRK-52E). These receptors underwent hetero-dimerization with adiponectin receptor AdipoR1 and AdipoR2, respectively...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28843075/expression-of-adiponectin-and-its-receptors-adipor1-and-adipor2-in-goat-ovary-and-its-effect-on-oocyte-nuclear-maturation-in%C3%A2-vitro
#16
Bruna S P Oliveira, Joana A S Costa, Elizabete T Gomes, Diogo M F Silva, Sandra M Torres, Pedro L J Monteiro, Antônio S Santos Filho, Maria Madalena P Guerra, Gustavo F Carneiro, Aurea Wischral, André M Batista
Adiponectin is an adipokine secreted primarily by adipocytes and is involved in the control of male and female reproductive functions. Circulating levels of adiponectin are inversely correlated with body fat mass, and its biological effects are predominantly mediated through two receptors, AdipoR1 and AdipoR2. The aim of the present study was to verify the expression of the adiponectin system (adiponectin and its receptors, AdipoR1 and AdipoR2) in goat ovary using qPCR and immunohistochemistry analyses and further investigate the in vitro effects of recombinant adiponectin (5 μg/mL and 10 μg/mL) on goat oocyte nuclear maturation...
August 18, 2017: Theriogenology
https://www.readbyqxmd.com/read/28837879/telmisartan-ameliorates-adipor1-and-adipor2-expression-via-ppar-%C3%AE-activation-in-the-coronary-artery-and-vsmcs
#17
Xuhua Shen, Hongwei Li, Weiping Li, Xing Wu, Zhijun Sun, Xiaosong Ding
The effects of telmisartan on insulin-resistant properties and expression of adiponectin receptors (AdipoRs) were investigated. A diabetic rat model was established using a high-fat diet and streptozotocin (25mg/kg) and primary rat coronary vascular smooth muscle cells (VSMCs) were used to elucidate the underlying mechanisms. The diabetic rats were insulin-resistant and exhibited weight gain, elevated blood pressures, and increased plasma triglyceride levels. These manifestations were ameliorated by elmisartan treatment...
November 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28811200/globular-adiponectin-reverses-osteo-sarcopenia-and-altered-body-composition-in-ovariectomized-rats
#18
Shyamsundar Pal China, Subhashis Pal, Sourav Chattopadhyay, Konica Porwal, Sapana Kushwaha, Sharmishtha Bhattacharyya, Monika Mittal, Anagha A Gurjar, Tarun Barbhuyan, Abhishek K Singh, Arun K Trivedi, Jiaur R Gayen, Sabyasachi Sanyal, Naibedya Chattopadhyay
Adiponectin regulates various metabolic processes including glucose flux, lipid breakdown and insulin response. We recently reported that adiponectin receptor1 (adipoR1) activation by a small molecule reverses osteopenia in leptin receptor deficient db/db (diabetic) mice. However, the role of adiponectin in bone metabolism under the setting of post-menopausal (estrogen-deficiency) osteopenia and associated metabolic derangements has not been studied. Here, we studied the therapeutic effect of the globular form of adiponectin (gAd), which is predominantly an adipoR1 agonist, in aged ovariectomized (OVX) rats and compared it with standard-of-care anti-osteoporosis drugs...
August 12, 2017: Bone
https://www.readbyqxmd.com/read/28804986/effects-of-hydroxycitric-acid-on-lipid-droplet-accumulation-in-chicken-embryos
#19
Mengling Peng, Longlong Li, Lei Yu, Chongyang Ge, Haitian Ma
This study was conducted to determine the impact of (-)-hydroxycitric acid ((-)-HCA) on biochemical indices and lipid metabolism parameters in chicken embryos. Two hundred and forty fertilized eggs were divided into six groups and injected with (-)-HCA at concentrations of 0, 0.1, 0.5, 1.0, 10.0 and 50 mg/kg (n = 40). After 19 days of incubation, serum and liver were collected for analysis of biochemical indices and lipid metabolism parameters. Results showed no significant differences on serum biochemical indices: 1-50 mg/kg (-)-HCA significantly increased serum glucose and hepatic glycogen contents (P < 0...
August 14, 2017: Animal Science Journal, Nihon Chikusan Gakkaihō
https://www.readbyqxmd.com/read/28780351/down-regulation-of-lncrna-kcnq1ot1-protects-against-myocardial-ischemia-reperfusion-injury-following-acute-myocardial-infarction
#20
Xin Li, Yingnan Dai, Shujun Yan, Yanli Shi, Baihe Han, Jingxiu Li, Li Cha, Jianjun Mu
This study aimed to investigate the protective effects of long non-coding RNA KCNQ1OT1 against myocardial ischemia/reperfusion (I/R) injury following acute myocardial infarction, as well as its regulatory mechanism. We used the cardiac muscle H9c2 cells under condition of oxygen glucose deprivation followed by reperfusion (OGD/R) to induce myocardial I/R injury. Then H9C2 cells were transfected with si-NC, si-KCNQ1OT1, pc-NC, pc-KCNQ1OT1, si-AdipoR1 and si-AdipoR2, respectively. The myocardial cell viability and apoptosis were respectively detected...
September 30, 2017: Biochemical and Biophysical Research Communications
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