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Pilocytic astrocytoma

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https://www.readbyqxmd.com/read/28928859/idh1-r132h-mutation-is-accompanied-with-malignant-progression-of-paired-primary-recurrent-astrocytic-tumours
#1
Luyan Mu, Wanzhen Xu, Qingla Li, Haitao Ge, Hongbo Bao, Songsong Xia, Jingjing Ji, Jie Jiang, Yuwen Song, Qiang Gao
IDH1 R132H mutation is an important marker of survival in patients with gliomas. Although there are many changes of genes in tumour malignant progression, IDH1 R132H mutation status in glioma progression remained unclear. Here, an in-depth characterization of IDH1 R132H mutations were assessed by immunohistochemistry in 55 paired primary-recurrent astrocytomas tissues, including 5 paired primary pilocytic astrocytoma (pPA, WHO grade I), 35 paired primary low grade astrocytoma (pLGA, WHO grade II and III) and 15 paired primary high grade astrocytoma (pHGA/ Glioblastoma, WHO grade IV)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28919136/pilocytic-astrocytoma-mimicking-cavernous-angioma-imaging-features-and-histological-characteristics
#2
M Gaha, F Bouzayen, Y Limam, M Mokni, H Jemni-Gharbi, K Tlili-Graiess
Pilocytic astrocytoma (PA) commonly occurs during the first two decades of life. Typical locations include cerebellum, optic nerve, optic chiasm/hypothalamus and brainstem. PA should be considered in the differential diagnosis of patients with brain tumors manifesting with hemorrhagic onset. We report a case of a hemorrhagic onset of cerebellar PA in a young adult with imaging findings mimicking cavernous angioma. We also discuss imaging features and histological characteristics with a focus on the etiology of the hemorrhagic onset...
September 15, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28880959/correction-a-new-gtf2i-braf-fusion-mediating-mapk-pathway-activation-in-pilocytic-astrocytoma
#3
Tajana Tešan Tomić, Josefin Olausson, Annica Wilzén, Magnus Sabel, Katarina Truvé, Helene Sjögren, Sándor Dósa, Magnus Tisell, Birgitta Lannering, Fredrik Enlund, Tommy Martinsson, Pierre Åman, Frida Abel
[This corrects the article DOI: 10.1371/journal.pone.0175638.].
2017: PloS One
https://www.readbyqxmd.com/read/28870453/spinal-cord-tumors-in-children-a-review-of-21-cases-treated-at-the-same-institution
#4
I Merlot, J Francois, J-C Marchal, A Joud, R Guerbouz, P Chastagner, O Klein
INTRODUCTION: Spinal cord tumors in children (SCTC) are rare with a frequent diagnostic delay. Its management is multidisciplinary and challenging due to functional implications. The position of surgery is now better established but the role and timing of chemotherapy (CT) and radiotherapy (RT) still remains under debate. Adverse effects of treatments are important to be taken into account, in the follow-up of these children. The aim of this paper was to present a series of 21 cases of SCTC treated at the same institution, to briefly present clinical features, treatments and outcome, with a special focus on spinal deformities in children with this condition...
September 1, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/28867398/visual-and-ocular-motor-outcomes-in-children-with-posterior-fossa-tumors
#5
Crandall E Peeler, Jane C Edmond, Jeffrey Hollander, Jamie K Alexander, David Zurakowski, Nicole J Ullrich, Peter E Manley, Gena Heidary
PURPOSE: To describe the clinical characteristics and visual and ocular motor outcomes of a large cohort of pediatric patients treated for tumors of the posterior cranial fossa. METHODS: The medical records of all patients with posterior fossa tumors evaluated by the ophthalmology services at two large tertiary care academic hospitals between 2005 and 2011 were reviewed retrospectively. Data abstracted for each study patient included demographic information, presenting signs and symptoms, pathologic diagnosis, and results of the most recent ophthalmology examination...
August 31, 2017: Journal of AAPOS: the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
https://www.readbyqxmd.com/read/28859336/molecular-analyses-reveal-inflammatory-mediators-in-the-solid-component-and-cyst-fluid-of-human-adamantinomatous-craniopharyngioma
#6
MULTICENTER STUDY
Andrew M Donson, John Apps, Andrea M Griesinger, Vladimir Amani, Davis A Witt, Richard C E Anderson, Toba N Niazi, Gerald Grant, Mark Souweidane, James M Johnston, Eric M Jackson, Bette K Kleinschmidt-DeMasters, Michael H Handler, Aik-Choon Tan, Lia Gore, Alex Virasami, Jose Mario Gonzalez-Meljem, Thomas S Jacques, Juan Pedro Martinez-Barbera, Nicholas K Foreman, Todd C Hankinson
Pediatric adamantinomatous craniopharyngioma (ACP) is a highly solid and cystic tumor, often causing substantial damage to critical neuroendocrine structures such as the hypothalamus, pituitary gland, and optic apparatus. Paracrine signaling mechanisms driving tumor behavior have been hypothesized, with IL-6R overexpression identified as a potential therapeutic target. To identify potential novel therapies, we characterized inflammatory and immunomodulatory factors in ACP cyst fluid and solid tumor components...
September 1, 2017: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/28853695/paradoxical-results-obtained-with-ki67-labeling-and-phh3-mitosis-index-in-glial-tumors-a-literature-analysis
#7
İlhan Elmaci, Meric A Altinoz, Fatih Han Bolukbasi, Ozlem Yapicier, Aydin Sav
Precise tiered tumor grading is essential for predicting prognosis, selecting different treatment options and for follow-up of brain tumor patients. Ki67 labeling index (LI) is widely employed in assessing aggressiveness of glial brain tumors. However, Ki67 is subject to interlaboratory variability, and its antigen is expressed on all cell cycle phases except G0, which hinders its usage as a precise criterion for assessing cell proliferation. Indeed, there exist peculiar observations pertinent to increases of Ki67 index in glial tumors following radiotherapy or treatment with tyrosine kinase inhibitors...
August 30, 2017: Clinical Neuropathology
https://www.readbyqxmd.com/read/28836232/diencephalic-pediatric-low-grade-glioma-harboring-the-braf-v600e-mutation-presenting-with-various-morphologies-in-sequential-biopsy-specimens
#8
Yukitomo Ishi, Kanako C Hatanaka, Shigeru Yamaguchi, Hiromi Fujita, Hiroaki Motegi, Hiroyuki Kobayashi, Shunsuke Terasaka, Kiyohiro Houkin
A 5-year-old boy underwent biopsy of an intra-axial calcified tumor in the hypothalamus, which was incidentally found. Based on the presence of ganglion-like cells combined with glial cell element, the pathological diagnosis was ganglioglioma. Because the tumor grew gradually in size over the next 2 years, he underwent chemotherapy with temozolomide. However, at 8 years of age, the boy developed hydrocephalus and the cystic lesion had re-grown. Endoscopic cyst fenestration and tumor biopsy was performed, and pathological diagnosis was tentatively oligodendroglioma based on the presence of tumor cells with a perinuclear halo...
August 23, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28807344/pituicytoma-review-of-commonalities-and-distinguishing-features-among-ttf-1-positive-tumors-of-the-central-nervous-system
#9
REVIEW
Siba El Hussein, Cristina Vincentelli
Pituicytoma is a rare low-grade glial neoplasm that originates in the distribution of the neurohypophysis, including the posterior pituitary lobe and infundibular stalk. The tumor cells resemble pituicytes, which are specialized glial cells of the neurohypophysis. Pituicytoma can be misdiagnosed pre-operatively as a pituitary adenoma due to overlapping clinical and neuroimaging features between these two entities. Pituicytoma can also mimic other neoplasms of the sellar and parasellar regions microscopically - meningioma, schwannoma and pilocytic astrocytoma - and shares immunohistochemical expression of TTF-1 with spindle cell oncocytoma and granular cell tumor of the sellar region, suggesting a common histogenesis...
August 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/28790217/-an-elderly-patient-with-pilocytic-astrocytoma-operated-on-14-years-after-initial-detection-a-case-study
#10
Naoyuki Isobe, Takeshi Nishimoto, Takeshi Ueda
Pilocytic astrocytomas are found predominantly in the pediatric population and are extremely rare in elderly patients. We describe a case of pilocytic astrocytoma in an elderly patient who presented with the symptoms of an enlarged tumoral cyst. A 70-year-old woman was found to have an asymptomatic small solid tumor with a cystic component in the right frontal lobe at "Ningen Dock(medical checkup)of the Brain". She was hospitalized and underwent further examinations including cerebral angiography. At that time, she was opposed to undergoing an operation for tumor removal owing to lack of symptoms...
August 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/28752498/pseudoprogression-in-pediatric-low-grade-glioma-after-irradiation
#11
Derek S Tsang, Erin S Murphy, John T Lucas, Pagona Lagiou, Sahaja Acharya, Thomas E Merchant
This study aimed to assess the incidence and management of pseudoprogression after radiation therapy (RT) in patients with pediatric low-grade glioma (LGG). This retrospective review included patients aged 21 years or younger with intracranial LGG treated with curative-intent RT. Pseudoprogression was defined as an increase in tumor size by ≥10% in at least two dimensions between two and three consecutive MR imaging studies. Overall survival (OS) and event-free survival (EFS) were measured from the first day of RT...
July 27, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28748803/serial-mri-scan-of-posterior-fossa-tumours-predict-patients-at-risk-of-developing-neurocognitive-impairment
#12
Ramadhan Othman, Kurdistan Gh Abdullah
Background: Brain tumours are the most common solid tumours in children. More than 50% of these tumours develop in the posterior cranial fossa. Long term survivors of posterior fossa tumours (PFT) suffer from neurocognitive and memory issues. We hypothesized that serial MRI scanning of brain would show differences in hippocampal and ACC volume change in PFT patients treated with and without chemo-radiotherapy. Material and Methods: Twelve patients (8 females and 4 males) underwent 76 serial MR imaging examinations before and during treatment for posterior fossa tumours...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28741227/posterior-fossa-pilomyxoid-astrocytoma-with-spontaneous-hemorrhage-in-pediatric-patients
#13
Jintao He, Xiang Li, Wanchun Zhu, Chunde Li, Jian Gong
OBJECT: The tumor described in this report was unique because of its involvement with a posterior fossa spontaneous hemorrhage in a pediatric patient; such a case has never been previously described in cases of pilomyxoid astrocytomas and also rarely found in those of pilocytic astrocytomas. METHODS: This report studied a rare case of posterior fossa pilomyxoid astrocytoma (PMA) with critical and dangerous spontaneous hemorrhage. A 7-year-old girl appeared at the outpatient clinic with sudden headache and vomiting...
July 24, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28708330/mortality-in-children-with-low-grade-glioma-or-glioneuronal-tumors-a-single-institution-study
#14
Santhosh A Upadhyaya, Yahya Ghazwani, Shengjie Wu, Alberto Broniscer, Fredrick A Boop, Amar Gajjar, Ibrahim Qaddoumi
BACKGROUND: While pediatric low-grade glioma/glioneuronal tumors (LGG/LGGNTs) are considered slow-growing, indolent tumors with excellent long-term prognosis, mortality due to the disease is not unknown. Few studies have addressed the cause of death in this population. METHODS: Retrospective review of clinicopathologic and radiologic data for children 21 years or younger with LGG/LGGNT who died at St. Jude Children's Research Hospital between April 1985 and June 2015...
July 14, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28690017/diagnosis-and-treatment-for-pure-aqueductal-tumor
#15
Ryota Tamura, Tomoru Miwa, Takayuki Ohira, Kazunari Yoshida
Pure aqueductal tumor (PAT) typically originates from pure aqueductal region and is extremely rare. It is radiographically similar to tectal glioma. We examined two patients with PATs who were diagnosed with pilocytic astrocytoma and rosette-forming glioneuronal tumor. Both cases showed a progressive clinical course. It is important to distinguish between PAT and tectal glioma by radiographic imaging because the treatment strategy is different. While observation is common for tectal gliomas, a biopsy is recommended at the same time of endoscopic third ventriculostomy for PAT with hydrocephalus...
October 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28687692/diencephalic-syndrome-a-rare-cause-of-failure-to-thrive
#16
Mustafa Tosur, Anca Tomsa, David L Paul
Timely diagnosis of diencephalic syndrome is not often the case for patients presenting with failure to thrive (FTT) because of its rarity and lack of specific symptoms. Herein, we report two cases of diencephalic syndrome (2-year-old girl and 10-month-old boy) presenting with severe emaciation. Both patients had histories of poor weight gain for months despite having good appetites prior to diagnosis. Initial work-up did not reveal the diagnosis. Horizontal nystagmus was noted in both patients: by a neurologist in the first patient and by a family member in the second patient...
July 6, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28686121/surgical-and-molecular-considerations-in-the-treatment-of-pediatric-thalamopeduncular-tumors
#17
Ryan P Lee, Kimberly A Foster, Jock C Lillard, Paul Klimo, David W Ellison, Brent Orr, Frederick A Boop
OBJECTIVE Thalamopeduncular tumors are a group of pediatric low-grade gliomas that arise at the interface of the thalamus and brainstem peduncle. They typically occur within the first 2 decades of life, presenting with progressive spastic hemiparesis. Treatment strategies, including surgical intervention, have varied significantly. The authors present their experience in the treatment of 13 children, ages 2-15 years, with non-neurofibromatosis-related pilocytic astrocytomas located in the thalamopeduncular region...
September 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28680735/pilocytic-astrocytoma-a-rare-presentation-as-intraventricular-tumor
#18
Sidra Sattar, Naveed Z Akhunzada, Gohar Javed, Zeeshan Uddin, Yasir A Khan
BACKGROUND: Pilocytic astrocytoma (PA) is the most prevalent central nervous system (CNS) tumor in pediatric population and accounts for an approximate of 5-6% of all gliomas. This neoplasm can occur at all levels of the neuraxis, with majority (67%) arising in the cerebellum and optic pathway. PAs are World Health Organization Grade I tumors and are the most benign of all astrocytomas characterized by an excellent prognosis. Other differentials include subependymal giant cell astrocytoma (SEGA), ependymoma, meningioma, and low-grade gliomas such as pilocytic or diffuse astrocytoma; calcification is more commonly regarded as a feature of benign or slow-growing tumors...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28674742/characterization-of-gliomas-from-morphology-to-molecules
#19
Sean P Ferris, Jeffrey W Hofmann, David A Solomon, Arie Perry
This article reviews the histologic and molecular characterization of gliomas, including the new "integrated diagnoses" of the World Health Organization Classification, 2016 edition. The entities reviewed within include diffuse gliomas (astrocytoma, oligodendroglioma, glioblastoma), as well as circumscribed and low-grade gliomas (angiocentric glioma, pilocytic astrocytoma, subependymal giant cell astrocytoma, pleomorphic xanthoastrocytoma, pilomyxoid astrocytoma, ependymoma, myxopapillary ependymoma, and subependymoma)...
July 4, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/28674731/tractography-guides-the-approach-for-resection-of-thalamopeduncular-tumors
#20
Ryan Foley, Frederick Boop
BACKGROUND: Thalamopeduncular tumors arise at the junction of the inferior thalamus and cerebral peduncle, and present with a common clinical syndrome of progressive spastic hemiparesis. METHOD: Formal preoperative magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI) were performed. Postoperative MRI was obtained to evaluate the extent of tumor resection. A prospective analysis of clinical outcomes was then conducted by the senior author. CONCLUSIONS: Preoperative tractography is a useful adjunct to surgical planning in tumors that displace motor pathways...
July 3, 2017: Acta Neurochirurgica
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