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Anaplastic astrocytoma

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https://www.readbyqxmd.com/read/29772361/comparative-histological-and-molecular-analysis-of-two-recurrent-lesions-showing-different-mr-imaging-responses-after-bevacizumab-treatment-report-of-a-case-of-anaplastic-astrocytoma
#1
Yoshihiro Otani, Tomotsugu Ichikawa, Atsuhito Uneda, Kazuhiko Kurozumi, Joji Ishida, Isao Date
BACKGROUND: We report the case of a patient with anaplastic astrocytoma whose two recurrent lesions showed different imaging responses from one another after bevacizumab treatment. Histological and genetic features of this patient are also described. CASE DESCRIPTION: A 31-year-old patient with left temporal anaplastic astrocytoma received surgery, local radiotherapy, and chemotherapy. Recurrent lesions appeared in the cerebellar vermis and left cerebellar hemisphere, and the patient was started on biweekly bevacizumab...
May 14, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29752851/idh-mutated-astrocytomas-with-19q-loss-constitute-a-subgroup-that-confers-better-prognosis
#2
Ryohei Otani, Takeo Uzuka, Fumi Higuchi, Hadzki Matsuda, Masashi Nomura, Shota Tanaka, Akitake Mukasa, Koichi Ichimura, Phyo Kim, Keisuke Ueki
IDH-mutant gliomas are classified into astrocytic or oligodendroglial tumors by 1p/19q status in WHO 2016 classification, with the latter presenting with characteristic morphology and better prognosis in general. However, the morphological and genetic features within each category are varied, and there may be distinguishable subtypes. We analyzed 170 WHO grade II to IV gliomas resected in our institution. 1p/19q status was analyzed by microsatellite analysis, and genetic mutations were analyzed by next-generation sequencing and Sanger sequencing...
May 12, 2018: Cancer Science
https://www.readbyqxmd.com/read/29739361/two-successful-pregnancies-following-fertility-preservation-in-a-patient-with-anaplastic-astrocytoma-a-case-report
#3
Alexandra Peyser, Sara L Bristow, Avner Hershlag
BACKGROUND: Astrocytomas are the most common malignant glial tumors. With improved prognosis, it is possible for patients to pursue pregnancy post-treatment. However, with potential gonadotoxicity of oncology treatments, fertility preservation prior to chemotherapy and/or radiation therapy should be considered. This requires close collaboration between the oncologist and reproductive endocrinologist. To our knowledge this is the first report of successful pregnancies following fertility preservation for AA...
May 9, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29732137/anaplasic-astrocytoma-with-exophytic-growth-in-sylvian-fissure-in-a-pediatric-patient-a-case-report
#4
José Raúl Guerra-Mora, Ulises Bravo-Ángel, Rodrigo Efraín Hernández-Reséndiz, Rosa María Vicuña-González, Jessica Frías-Guillén, Irina Jeanette Bercholc-Urinowsky, Carlos Cesar Bravo-Reyna, Ulises García-González
Gliomas are the most frequent supratentorial intracranial tumors in the pediatric population. Usually, they are intra-axial lesions with a characteristic image pattern, however, there are few reported cases of gliomas with exophytic growth. There are no previous reports in the literature of gliomas with exophytic growth in the Sylvian fissure. Fourteen year-old female patient who started with seizures. In imaging studies, a neoplasic mass with an exophytic portion in the left Sylvian fissure was found. Macroscopically, total resection was performed, definitive diagnosis was anaplastic astrocytoma...
April 2018: Journal of Surgical Case Reports
https://www.readbyqxmd.com/read/29718398/targetable-gene-fusions-associate-with-the-idh-wild-type-astrocytic-lineage-in-adult-gliomas
#5
Sherise D Ferguson, Shouhao Zhou, Jason T Huse, John F de Groot, Joanne Xiu, Deepa S Subramaniam, Shwetal Mehta, Zoran Gatalica, Jeffrey Swensen, Nader Sanai, David Spetzler, Amy B Heimberger
Gene fusions involving oncogenes have been reported in gliomas and may serve as novel therapeutic targets. Using RNA-sequencing, we interrogated a large cohort of gliomas to assess for the incidence of targetable genetic fusions. Gliomas (n = 390) were profiled using the ArcherDx FusionPlex Assay. Fifty-two gene targets were analyzed and fusions with preserved kinase domains were investigated. Overall, 36 gliomas (9%) harbored a total of 37 potentially targetable fusions, the majority of which were found in astrocytomas (n = 34)...
April 27, 2018: Journal of Neuropathology and Experimental Neurology
https://www.readbyqxmd.com/read/29704688/diffusely-infiltrating-cerebellar-anaplastic-astrocytoma-effectively-controlled-with-bevacizumab-case-report-and-literature-review
#6
Hidehiro Kohzuki, Masahide Matsuda, Shunichiro Miki, Makoto Shibuya, Eiichi Ishikawa, Akira Matsumura
No abstract text is available yet for this article.
April 25, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29687258/novel-improved-grading-system-s-for-idh-mutant-astrocytic-gliomas
#7
Mitsuaki Shirahata, Takahiro Ono, Damian Stichel, Daniel Schrimpf, David E Reuss, Felix Sahm, Christian Koelsche, Annika Wefers, Annekathrin Reinhardt, Kristin Huang, Philipp Sievers, Hiroaki Shimizu, Hiroshi Nanjo, Yusuke Kobayashi, Yohei Miyake, Tomonari Suzuki, Jun-Ichi Adachi, Kazuhiko Mishima, Atsushi Sasaki, Ryo Nishikawa, Melanie Bewerunge-Hudler, Marina Ryzhova, Oksana Absalyamova, Andrey Golanov, Peter Sinn, Michael Platten, Christine Jungk, Frank Winkler, Antje Wick, Daniel Hänggi, Andreas Unterberg, Stefan M Pfister, David T W Jones, Martin van den Bent, Monika Hegi, Pim French, Brigitta G Baumert, Roger Stupp, Thierry Gorlia, Michael Weller, David Capper, Andrey Korshunov, Christel Herold-Mende, Wolfgang Wick, David N Louis, Andreas von Deimling
According to the 2016 World Health Organization Classification of Tumors of the Central Nervous System (2016 CNS WHO), IDH-mutant astrocytic gliomas comprised WHO grade II diffuse astrocytoma, IDH-mutant (AIIIDHmut ), WHO grade III anaplastic astrocytoma, IDH-mutant (AAIIIIDHmut ), and WHO grade IV glioblastoma, IDH-mutant (GBMIDHmut ). Notably, IDH gene status has been made the major criterion for classification while the manner of grading has remained unchanged: it is based on histological criteria that arose from studies which antedated knowledge of the importance of IDH status in diffuse astrocytic tumor prognostic assessment...
April 23, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29684925/minimally-invasive-resection-of-deep-seated-high-grade-gliomas-using-tubular-retractors-and-exoscopic-visualization
#8
Rajiv Iyer, Kaisorn L Chaichana
BACKGROUND AND STUDY AIMS/OBJECTIVE:  Deep-seated high-grade gliomas (HGGs) represent a unique surgical challenge because they reside deep to critical cortical and subcortical structures and infiltrate functional areas of the brain. Therefore, accessing and resecting these tumors can often be challenging and associated with significant morbidity. We describe the use of minimally invasive approaches to access deep-seated HGGs to achieve extensive resections while minimizing surgical morbidity...
April 23, 2018: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/29621181/dabrafenib-treatment-in-a-patient-with-an-epithelioid-glioblastoma-and-braf-v600e-mutation
#9
Garry Ceccon, Jan-Michael Werner, Veronika Dunkl, Caroline Tscherpel, Gabriele Stoffels, Anna Brunn, Martina Deckert, Gereon R Fink, Norbert Galldiks
Novel therapeutic targets in malignant glioma patients are urgently needed. Point mutations of the v-Raf murine sarcoma viral oncogene homolog B ( BRAF ) gene occur predominantly in melanoma patients, but may also occur in gliomas. Thus, this is a target of great interest for this group of patients. In a nine-year-old male patient, an anaplastic astrocytoma in the left temporoparietal region was diagnosed histologically. After first- and second-line treatment, a malignant progression to a secondary glioblastoma was observed ten years after the initial diagnosis...
April 5, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29617945/intracranial-neoplasms-in-the-first-year-of-life-results-of-a-third-cohort-of-patients-from-a-single-institution
#10
Sebastian M Toescu, Gregory James, Kim Phipps, Owase Jeelani, Dominic Thompson, Richard Hayward, Kristian Aquilina
BACKGROUND: Brain tumors in the first year of life are rare and their management remains challenging. OBJECTIVE: To report on the contemporary management of brain tumors in infants with reference to previous series from our institution. METHODS: Retrospective cohort study design. Electronic/paper case note review of all brain tumors diagnosed at our institution in children aged <1 yr since the publication of our previous series. RESULTS: Ninety-eight patients were seen...
April 3, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29613896/neoplastic-myelopathies
#11
Jing Wu, Surabhi Ranjan
PURPOSE OF REVIEW: This article discusses the diagnosis and management of neoplasms that affect the spinal cord as well as spinal cord disorders that can occur due to cancer treatments. RECENT FINDINGS: Neoplastic myelopathies are uncommon neurologic disorders but cause significant morbidity when they occur. Primary spinal cord tumors can be classified into intramedullary, intradural extramedullary, or extradural tumors. Diffuse gliomas and ependymal tumors are the most common intramedullary tumors...
April 2018: Continuum: Lifelong Learning in Neurology
https://www.readbyqxmd.com/read/29610389/-fgfr1-tyrosine-kinase-domain-duplication-in-pilocytic-astrocytoma-with-anaplasia
#12
Leomar Y Ballester, Marta Penas-Prado, Norman E Leeds, Jason T Huse, Gregory N Fuller
We report the case of a 27-yr-old male with visual field loss who had a 4.9-cm complex cystic mass in the right occipital lobe. Histologic examination showed pilocytic astrocytoma (PA) with anaplasia, and molecular characterization revealed FGFR1 duplication with additional variants of unknown significance in several genes ( ARID1A, ARID1B, CHEK2, EPHA5, and MLL2 ). This is one of only a very few reported cases of anaplastic PA with characterization of molecular alterations.
April 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29602769/whole-exome-sequencing-identifies-germline-mutation-in-tp53-and-atrx-in-a-child-with-ge-nomically-aberrant-at-rt-and-her-mother-with-anaplastic-astrocytoma
#13
Kristiina Nordfors, Joonas Haapasalo, Ebrahim Afyounian, Joonas Tuominen, Matti Annala, Sergei Hayrynen, Ritva Karhu, Pauli Helen, Olli Lohi, Matti Nykter, Hannu Haapasalo, Kirsi Granberg
Brain tumors typically arise sporadically and do not affect several family members simultaneously. In the present study, we describe clinical and genetic data from two patients, a mother and her daughter, with familial brain tumors. Exome sequencing revealed a germline missense mutation in the TP53 and ATRX genes in both cases, and a somatic copy-neutral loss of heterozygosity (LOH) in TP53 in both atypical teratoid/rhabdoid tumor (AT/RT) and astrocytoma tumors. ATRX mutation was associated with the loss of ATRX protein expression...
March 30, 2018: Cold Spring Harbor Molecular Case Studies
https://www.readbyqxmd.com/read/29600221/prognostic-factors-and-outcomes-in-anaplastic-gliomas-an-institutional-experience
#14
Deepthi Valiyaveettil, Monica Malik, Deepa Joseph, Syed Fayaz Ahmed, Syed Akram Kothwal
Background: There is lack of clear evidence and treatment guidelines for anaplastic gliomas (AGs) with very few studies focusing exclusively on these patients. The aim of the study was to analyze the clinical profile and survival in these patients. Materials and Methods: Patients of AGs treated with radiation and concurrent ± adjuvant chemotherapy from January 2010 to December 2015 were analyzed. Statistical analysis was done using SPSS version 20 software. Results: A total of 100 patients were included in the study...
January 2018: South Asian Journal of Cancer
https://www.readbyqxmd.com/read/29594248/analysis-of-pseudoprogression-after-proton-or-photon-therapy-of-99-patients-with-low-grade-and-anaplastic-glioma
#15
Julianna K Bronk, Nandita Guha-Thakurta, Pamela K Allen, Anita Mahajan, David R Grosshans, Susan L McGovern
Background and purpose: Proton therapy is increasingly used to treat primary brain tumors. There is concern for higher rates of pseudoprogression (PsP) after protons compared to photons. The purposes of this study are to compare the rate of PsP after proton vs. photon therapy for grade II and III gliomas and to identify factors associated with the development of PsP. Materials and methods: Ninety-nine patients age >18 years with grade II or III glioma treated with photons or protons were retrospectively reviewed...
February 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29590424/the-t2-flair-mismatch-sign-as-an-imaging-marker-for-non-enhancing-idh-mutant-1p-19q-intact-lower-grade-glioma-a-validation-study
#16
Martinus P G Broen, Marion Smits, Maarten M J Wijnenga, Hendrikus J Dubbink, Monique H M E Anten, Olaf E M G Schijns, Jan Beckervordersandforth, Alida A Postma, Martin J van den Bent
Background: The purpose of this study was to assess the reproducibility of the previously described T2-FLAIR mismatch sign as a specific imaging marker in non-enhancing isocitrate dehydrogenase (IDH) mutant, 1p/19q non-codeleted lower grade glioma (LGG), encompassing both diffuse and anaplastic astrocytoma. Methods: MR scans (n=154) from three separate databases with genotyped LGG were evaluated by two independent reviewers to assess (i) presence/absence of "T2-FLAIR mismatch" sign and (ii) presence/absence of homogenous signal on T2WI...
March 26, 2018: Neuro-oncology
https://www.readbyqxmd.com/read/29581022/neuro-endoscopic-cylinder-surgery-and-5-aminolevulinic-acid-5-ala-photodynamic-diagnosis-of-deep-seated-intracranial-lesions
#17
Jungsu Choo, Kazuhito Takeuchi, Yuichi Nagata, Fumiharu Ohka, Yugo Kishida, Tadashi Watanabe, Yusuke Satoh, Tetsuya Nagatani, Kyozo Kato, Toshihiko Wakabayashi, Atsushi Natsume
BACKGROUND: Microscopic detection of intracranial brain tumors with 5-aminolevulinic acid (5-ALA) has proven extremely useful, and reports the use of 5-ALA have recently increased. However, few reports have described 5-ALA photodynamic diagnosis (PDD) using a neuro-endoscope. We performed neuro-endoscopic 5-ALA PDD for various brain lesions and present a procedure using only a neuro-endoscope. METHODS: We describe the diagnosis of 20 intracranial brain lesion cases with a 5-ALA-guided fluorescence endoscope...
March 23, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29564749/characteristics-of-time-activity-curves-obtained-from-dynamic-11-c-methionine-pet-in-common-primary-brain-tumors
#18
Yuichi Nomura, Yoshitaka Asano, Jun Shinoda, Hirohito Yano, Yuka Ikegame, Tomohiro Kawasaki, Noriyuki Nakayama, Takashi Maruyama, Yoshihiro Muragaki, Toru Iwama
PURPOSE: The aim of this study was to assess whether dynamic PET with11 C-methionine (MET) (MET-PET) is useful in the diagnosis of brain tumors. METHODS: One hundred sixty patients with brain tumors (139 gliomas, 9 meningiomas, 4 hemangioblastomas and 8 primary central nervous system lymphomas [PCNSL]) underwent dynamic MET-PET with a 3-dimensional acquisition mode, and the maximum tumor MET-standardized uptake value (MET-SUV) was measured consecutively to construct a time-activity curve (TAC)...
March 21, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29564591/anaplastic-astrocytoma-with-piloid-features-a-novel-molecular-class-of-idh-wildtype-glioma-with-recurrent-mapk-pathway-cdkn2a-b-and-atrx-alterations
#19
Annekathrin Reinhardt, Damian Stichel, Daniel Schrimpf, Felix Sahm, Andrey Korshunov, David E Reuss, Christian Koelsche, Kristin Huang, Annika K Wefers, Volker Hovestadt, Martin Sill, Dorothee Gramatzki, Joerg Felsberg, Guido Reifenberger, Arend Koch, Ulrich-W Thomale, Albert Becker, Volkmar H Hans, Marco Prinz, Ori Staszewski, Till Acker, Hildegard Dohmen, Christian Hartmann, Wolf Mueller, Muin S A Tuffaha, Werner Paulus, Katharina Heß, Benjamin Brokinkel, Jens Schittenhelm, Camelia-Maria Monoranu, Almuth Friederike Kessler, Mario Loehr, Rolf Buslei, Martina Deckert, Christian Mawrin, Patricia Kohlhof, Ekkehard Hewer, Adriana Olar, Fausto J Rodriguez, Caterina Giannini, Amulya A NageswaraRao, Uri Tabori, Nuno Miguel Nunes, Michael Weller, Ute Pohl, Zane Jaunmuktane, Sebastian Brandner, Andreas Unterberg, Daniel Hänggi, Michael Platten, Stefan M Pfister, Wolfgang Wick, Christel Herold-Mende, David T W Jones, Andreas von Deimling, David Capper
Tumors with histological features of pilocytic astrocytoma (PA), but with increased mitotic activity and additional high-grade features (particularly microvascular proliferation and palisading necrosis) have often been designated anaplastic pilocytic astrocytomas. The status of these tumors as a separate entity has not yet been conclusively demonstrated and molecular features have only been partially characterized. We performed DNA methylation profiling of 102 histologically defined anaplastic pilocytic astrocytomas...
March 21, 2018: Acta Neuropathologica
https://www.readbyqxmd.com/read/29550762/phosphorylated-hsp27-is-mutually-exclusive-with-atrx-loss-and-the-idh1-r132h-mutation-and-may-predict-better-prognosis-among-glioblastomas-without-the-idh1-mutation-and-atrx-loss
#20
Hong-Qing Cai, Peng-Fei Wang, Hai-Peng Zhang, Zhi-Jian Cheng, Shou-Wei Li, Jie He, Yu Zhang, Jia-Jie Hao, Ming-Rong Wang, Chang-Xiang Yan, Jing-Hai Wan
AIM: To identify biomarkers for accurate classification of glioma. PATIENTS AND METHODS: We evaluated the heat shock protein 27 (Hsp27), phosphorylated Hsp27 (p-Hsp27), ATRX and IDH1R132H proteins using immunohistochemistry in 421 glioma tissues. The χ2 test was used to assess the relationship between molecular alterations and clinico-pathological parameters. Kaplan-Meier survival curves were constructed, and differences were detected by the log-rank test. RESULTS: We found that Hsp27 and p-Hsp27 were mainly expressed in aggressive astrocytic gliomas...
March 17, 2018: Journal of Clinical Pathology
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