keyword
MENU ▼
Read by QxMD icon Read
search

Anaplastic astrocytoma

keyword
https://www.readbyqxmd.com/read/28640702/diffuse-infiltrating-oligodendroglioma-and-astrocytoma
#1
Martin J van den Bent, Marion Smits, Johan M Kros, Susan M Chang
The new 2016 WHO brain tumor classification defines different diffuse gliomas primarily according to the presence or absence of IDH mutations ( IDH-mt) and combined 1p/19q loss. Today, the diagnosis of anaplastic oligodendroglioma requires the presence of both IDH-mt and 1p/19q co-deletion, whereas anaplastic astrocytoma is divided into IDH wild-type ( IDH-wt) and IDH-mt tumors. IDH-mt tumors have a more favorable prognosis, and tumors with low-grade histology especially tend evolve slowly. IDH-wt tumors are not a homogeneous entity and warrant further molecular testing because some have glioblastoma-like molecular features with poor clinical outcome...
June 22, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28629398/anaplastic-astrocytoma-mimicking-progressive-multifocal-leucoencephalopathy-a-case-report-and-review-of-the-overlapping-syndromes
#2
Ema Kantorová, Michal Bittšanský, Štefan Sivák, Eva Baranovičová, Petra Hnilicová, Vladimír Nosáľ, Daniel Čierny, Kamil Zeleňák, Wolfgang Brück, Egon Kurča
BACKGROUND: Co-occurrence of multiple sclerosis (MS) and glial tumours (GT) is uncommon although occasionally reported in medical literature. Interpreting the overlapping radiologic and clinical characteristics of glial tumours, MS lesions, and progressive multifocal leukoencephalopathy (PML) can be a significant diagnostic challenge. CASE PRESENTATION: We report a case of anaplastic astrocytoma mimicking PML in a 27-year-old patient with a 15-year history of MS...
June 19, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28592077/-clinical-effects-of-microsurgery-in-spinal-cord-anaplastic-astrocytoma
#3
L Zhang, W Q Jia, D S Kong, Z F Zhang, J Yang
Objective: To investigate the surgical outcomes and prognosis of spinal cord anaplastic astrocytoma (AA). Methods: A total of 27 consecutive patients diagnosed as spinal cord AA between January 2008 and May 2015 in Department of Neurosurgery of Beijing Tiantan Hospital were retrospectively reviewed. There were 18 males and 9 females, the mean age was (30.7±13.0) years (ranging from 5 to 52 years). The lesions were located at cervical level in 8 patients, at thoracic level in 9 patients, at cervicothoracic level in 3 patients, and at thoracolumbar level in 7 patients, the average number of vertebral was 3...
June 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28591062/extracranial-bone-metastases-from-recurrent-anaplastic-astrocytoma-on-fdg-pet-ct-a-case-report-a-care-compliant-article
#4
Zu-Gui Li, Hai-Yu Mu
OBJECTIVE: Extracranial bone metastases from astrocytoma are rare and frequently detected as part of multiorgan metastases. It is extremely rare for astrocytoma to have extracranial bone metastases alone. The importance of whole-body fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging in evaluating extracranial metastasis (ECMs) has not been described effectively due to the rarity of this event. The purpose of our case report is to emphasize the role of FDG PET/CT in the assessment of tumor recurrence and extracranial bone metastases from anaplastic astrocytoma...
June 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28587939/temozolomide-and-sorafenib-as-programmed-cell-death-inducers-of-human-glioma-cells
#5
Joanna Jakubowicz-Gil, Dorota Bądziul, Ewa Langner, Iwona Wertel, Adrian Zając, Wojciech Rzeski
BACKGROUND: Gliomas are aggressive brain tumors with very high resistance to chemotherapy. Therefore, the aim of the present study was to investigate the effectiveness of sorafenib and Temozolomide in elimination of human glioma cells through apoptosis and autophagy. METHODS: MOGGCCM (anaplastic astrocytoma) and T98G (glioblastoma multiforme) cell lines incubated with sorafenib and/or Temozolomide were used in the experiments. Cell morphology (ER stress, apoptosis, autophagy, and necrosis) was analyzed microscopically while apoptosis and mitochondrial membrane potential were assessed with flow cytometry...
March 14, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28571159/anaplastic-pleomorphic-xanthoastrocytoma-in-a-case-of-neurofibromatosis-type-1-a-case-report
#6
K Thara, Reetika Sharma, G Thiagarajan, Anita Ramdas, Renu Gboy Varghese
Pleomorphic Xanthoastrocytoma (PXA) is a rare brain tumour comprising only <1% of primary brain tumours which is seen in children and young adults. Only 9-20% of the PXA shows anaplastic features and this has a bad prognosis. PXA is a WHO grade II tumour while anaplastic PXA is a WHO grade III tumour. Neurofibromatosis type 1(NF1), which is an autosomal dominant condition, predisposes to tumours of the central nervous system; most of which are pilocytic astrocytomas. Association of PXA with NF1 is very rare and only a very few cases have been reported...
April 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28512257/comparison%C3%A2-of-chemoradiotherapy%C3%A2-with-radiotherapy-alone-for-biopsy-only-anaplastic-astrocytoma
#7
Jing Wu, Ting Zou, Harrison Xiao Bai, Xuejun Li, Zishu Zhang, Bo Xiao, MacLean Nasrallah, Giorgos Karakousis, Ya Cao, Paul J Zhang, Li Yang
BACKGROUND: It has become increasingly common to incorporate adjuvant chemotherapy with radiotherapy in the treatment of resected anaplastic astrocytoma based on results from recent phase II/III randomized trials. However, whether or not combined chemoradiotherapy is associated with improved survival outcome in patients who undergo "biopsy only" is less clear. METHODS: The US National Cancer Data Base was used to identify patients with histologically confirmed, biopsy-only anaplastic astrocytoma who received either radiotherapy alone or combined chemoradiotherapy from 2006 through 2014...
April 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28508327/assessment-of-molecular-markers-demonstrates-concordance-between-samples-acquired-via-stereotactic-biopsy-and-open-craniotomy-in-both-anaplastic-astrocytomas-and-glioblastomas
#8
Florian Gessler, Peter Baumgarten, Joshua D Bernstock, Patrick Harter, Stephanie Lescher, Christian Senft, Volker Seifert, Gerhard Marquardt, Lutz Weise
The classification, treatment and prognosis of high-grade gliomas has been shown to correlate with the expression of molecular markers (e.g. MGMT promotor methylation and IDH1 mutations). Acquisition of tumor samples may be obtained via stereotactic biopsy or open craniotomy. Between the years 2009 and 2013, 22 patients initially diagnosed with HGGs via stereotactic biopsy, that ultimately underwent open craniotomy for resection of their tumor were prospectively included in an institutional glioma database...
May 15, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28498059/oligodendroglioma-resection-a-surveillance-epidemiology-and-end-results-seer-analysis
#9
Ali A Alattar, Michael G Brandel, Brian R Hirshman, Xuezhi Dong, Kate T Carroll, Mir Amaan Ali, Bob S Carter, Clark C Chen
OBJECTIVE The available evidence suggests that the clinical benefits of extended resection are limited for chemosensitive tumors, such as primary CNS lymphoma. Oligodendroglioma is generally believed to be more sensitive to chemotherapy than astrocytoma of comparable grades. In this study the authors compare the survival benefit of gross-total resection (GTR) in patients with oligodendroglioma relative to patients with astrocytoma. METHODS Using the Surveillance, Epidemiology, and End Results (SEER) Program (1999-2010) database, the authors identified 2378 patients with WHO Grade II oligodendroglioma (O2 group) and 1028 patients with WHO Grade III oligodendroglioma (O3 group)...
May 12, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28492209/some-characteristics-of-gliomas-managed-at-a-neurosurgery-centre-in-nigeria
#10
Chika A Ndubuisi, Samuel C Ohaegbulam, Mark O Chikani, Wilfred C Mezue, Tobechi Mbadugha, Mark Okhueleigbe
BACKGROUND: Gliomas are important primary brain tumours with varying prognosis. AIM: To study the histology characteristics of brain gliomas managed in a Neurosurgical centre in Nigeria. MATERIALS AND METHODS: A retrospective analysis of prospectively recorded data of patients managed for intracranial gliomas at our Hospital for Neurosurgery, between year 2006 and 2015. Only the patients with conclusive histology diagnosis following surgery were analysed...
January 2017: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28488122/the-potential-of-cellular-and-viral-based-immunotherapies-for-malignant-glioma-dendritic-cell-vaccines-adoptive-cell-transfer-and-oncolytic-viruses
#11
REVIEW
Russell Maxwell, Andrew S Luksik, Tomas Garzon-Muvdi, Michael Lim
PURPOSE OF REVIEW: Malignant gliomas, including glioblastoma and anaplastic astrocytoma, are the most frequent primary brain tumors and present with many treatment challenges. In this review, we discuss the potential of cellular- and viral-based immunotherapies in the treatment of malignant glioma, specifically focusing on dendritic cell vaccines, adoptive cell therapy, and oncolytic viruses. RECENT FINDINGS: Diverse cellular- and viral-based strategies have been engineered and optimized to generate either a specific or broad antitumor immune response in malignant glioma...
June 2017: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/28485350/a-case-series-of-salvage-ccnu-in-high-grade-glioma-who-have-previously-received-temozolomide-from-a-tertiary-care-institute-in-mumbai
#12
V M Patil, R Abhinav, R Tonse, S Epari, T Gupta, R Jalali
INTRODUCTION: In our center, we routinely use CCNU (Lomustine) as salvage treatment in high-grade glioma patients who cannot afford bevacizumab. This exploratory analysis was done to report the efficacy and toxicity associated with this regimen. METHODS: Patients who were treated with salvage CCNU (postexposure to temozolomide) between January 2015 and August 2016 were included for this retrospective analysis. SPSS version 16 was used for this analysis. Time-to-event analysis was performed using the Kaplan-Meier method...
October 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28452381/transcriptome-analysis-reveals-distinct-gene-expression-profiles-in-astrocytoma-grades-ii-iv
#13
Nato Narsia, Pradeep Ramagiri, Jiri Ehrmann, Zdenek Kolar
BACKGROUND: Astrocytoma is the most prevalent form of primary brain cancer categorized into four histological grades by the World Health Organization. Investigation into individual grades of astrocytoma by previous studies has provided some insight into dysregulation of regulatory networks associated with increasing astrocytoma grades. However, further understanding of key mechanisms that distinguish different astrocytoma grades is required to facilitate targeted therapies. METHODS: In this study, we utilized a large cohort of publicly available RNA sequencing data from patients with diffuse astrocytoma (grade II), anaplastic astrocytoma (grade III), primary glioblastoma (grade IV), secondary glioblastoma (grade IV), recurrent glioblastoma (grade IV), and normal brain samples to identify genetic similarities and differences between these grades using bioinformatics applications...
April 26, 2017: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
https://www.readbyqxmd.com/read/28451406/anaplastic-astrocytoma-cells-not-detectable-on-autopsy-following-long-term-temozolomide-treatment-a-case-report
#14
Hirofumi Hirano, Takashi Kawahara, Masaki Niiro, Hajime Yonezawa, Tomoko Takajyou, Yasuyo Ohi, Ikumi Kitazono, Kiyohiro Sakae, Kazunori Arita
We herein present an autopsy case of a glioma patient who received long-term treatment with temozolomide (TMZ). The patient, a 35-year-old man with a hypointense tumor of the left frontal lobe, without contrast enhancement following gadolinium (Gd) administration on T1-weighted images, underwent tumor removal surgery, after which the tumor was diagnosed as anaplastic astrocytoma. By the third round of surgery, the tumor had progressed to anaplastic astrocytoma with contrast enhancement following Gd administration, and the patient received 60 Gy of external beam radiotherapy and nimustine hydrochloride (ACNU)-based chemotherapy...
March 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/28432586/cdc20-with-malignant-progression-and-poor-prognosis-of-astrocytoma-revealed-by-analysis-on-gene-expression
#15
Yiming Ding, Shuqing Yu, Zhaoshi Bao, Yanwei Liu, Tingyu Liang
The malignant transformation of astrocytoma may result from the accumulation of multiple genetic alterations. Current research shows that diffuse astrocytoma (AIIs, WHO grade II) is inherently predisposed to recur locally, and to spontaneously progress to anaplastic astrocytoma (AAIIIs, WHO grade III) and eventually secondary glioblastoma (sGBMIVs, WHO grade IV). The aim of the study was to identify and validate the important gene(s) associated with malignant progression and poor prognosis of astrocytoma. Average expression levels of 82 samples (35 AIIs, 13 AAIIIs and 34 sGBMIVs) were compared to each other through no-paired student test...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28412241/cathepsin-l-silencing-increases-as2o3-toxicity-in-malignantly-transformed-pilocytic-astrocytoma-mpa58-cells-by-activating-caspases-3-7
#16
Monika Primon, Peter C Huszthy, Helena Motaln, Krishna M Talasila, Hrvoje Miletic, Nadia A Atai, Rolf Bjerkvig, Tamara Lah Turnšek
Low-grade, pilocytic astrocytomas are treated by resection, but additional therapy is necessary for those tumors with anaplastic features. Arsenic trioxide (As2O3) is emerging as an effective chemotherapeutic agent for treatment of malignant glioblastoma multiforme, where Cathepsin L silencing enables lower, less harmful As2O3 concentrations to achieve the desired cytotoxic effect. Here, we evaluated the effects of As2O3 combined with stable Cathepsin L shRNA silencing on cell viability/metabolic activity, and apoptosis in primary cultures of recurrent malignantly transformed pilocytic astrocytoma (MPA)...
April 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28408259/pediatric-basal-ganglia-region-tumors-clinical-and-radiological-features-correlated-with-histopathological-findings
#17
Wei Fu, Yan Ju, Si Zhang, Chao You
PURPOSE: To summarize the clinical and radiological features of pediatric basal ganglia region tumors (PBGRT) in correlation with their histopathological findings to reduce inappropriate surgery and identify tumors that can benefit from maximal safe resection. METHODS: The records of 35 children with PBGRT treated in our hospital from December 2011 to December 2015 were retrospectively analyzed. The clinical and radiological features of these tumors were summarized in correlated with their histopathological diagnosis...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28394259/a-proangiogenic-signaling-axis-in-myeloid-cells-promotes-malignant-progression-of-glioma
#18
Yujie Huang, Prajwal Rajappa, Wenhuo Hu, Caitlin Hoffman, Babacar Cisse, Joon-Hyung Kim, Emilie Gorge, Rachel Yanowitch, William Cope, Emma Vartanian, Raymond Xu, Tuo Zhang, David Pisapia, Jenny Xiang, Jason Huse, Irina Matei, Hector Peinado, Jacqueline Bromberg, Eric Holland, Bi-Sen Ding, Shahin Rafii, David Lyden, Jeffrey Greenfield
Tumors are capable of coopting hematopoietic cells to create a suitable microenvironment to support malignant growth. Here, we have demonstrated that upregulation of kinase insert domain receptor (KDR), also known as VEGFR2, in a myeloid cell sublineage is necessary for malignant progression of gliomas in transgenic murine models and is associated with high-grade tumors in patients. KDR expression increased in myeloid cells as myeloid-derived suppressor cells (MDSCs) accumulated, which was associated with the transformation and progression of low-grade fibrillary astrocytoma to high-grade anaplastic gliomas...
May 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28387849/toca-511-gene-transfer-and-treatment-with-the-prodrug-5-fluorocytosine-promotes-durable-antitumor-immunity-in-a-mouse-glioma-model
#19
Leah A Mitchell, Fernando Lopez Espinoza, Daniel Mendoza, Yuki Kato, Akihito Inagaki, Kei Hiraoka, Noriyuki Kasahara, Harry E Gruber, Douglas J Jolly, Joan M Robbins
Background.: Toca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding an optimized yeast cytosine deaminase (CD). Tumor-selective expression of CD converts the prodrug, 5-fluorocytosine (5-FC), into the active chemotherapeutic, 5-fluorouracil (5-FU). This therapeutic approach is being tested in a randomized phase II/III trial in recurrent glioblastoma and anaplastic astrocytoma (NCT0241416). The aim of this study was to identify the immune cell subsets contributing to antitumor immune responses following treatment with 5-FC in Toca 511-expressing gliomas in a syngeneic mouse model...
April 6, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28384867/vascular-endothelial-growth-factor-as-an-angiogenic-marker-in-malignant-astrocytoma-and-oligodendroglioma-an-indian-scenario
#20
Ramya S Vokuda, Bheemanathi Hanuman Srinivas, Venkatesh S Madhugiri, Surendra Kumar Verma
INTRODUCTION: The role of Vascular Endothelial Growth Factor (VEGF) in angiogenesis has been extensively studied in gliomas, such as astrocytoma and oligodendrogliomas, worldwide. However, there is limited information available with regard to the Indian population. AIM: To study, whether VEGF is expressed in the Indian population in a pattern similar to that in other population. MATERIALS AND METHODS: In this prospective study approved by the Institute Ethics Committee for Human Studies at Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER) the patients operated for glioma in 2014 and 2015 (n = 60) were included...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
keyword
keyword
57639
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"