keyword
MENU ▼
Read by QxMD icon Read
search

Anaplastic astrocytoma

keyword
https://www.readbyqxmd.com/read/28432586/cdc20-with-malignant-progression-and-poor-prognosis-of-astrocytoma-revealed-by-analysis-on-gene-expression
#1
Yiming Ding, Shuqing Yu, Zhaoshi Bao, Yanwei Liu, Tingyu Liang
The malignant transformation of astrocytoma may result from the accumulation of multiple genetic alterations. Current research shows that diffuse astrocytoma (AIIs, WHO grade II) is inherently predisposed to recur locally, and to spontaneously progress to anaplastic astrocytoma (AAIIIs, WHO grade III) and eventually secondary glioblastoma (sGBMIVs, WHO grade IV). The aim of the study was to identify and validate the important gene(s) associated with malignant progression and poor prognosis of astrocytoma. Average expression levels of 82 samples (35 AIIs, 13 AAIIIs and 34 sGBMIVs) were compared to each other through no-paired student test...
April 21, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28412241/cathepsin-l-silencing-increases-as2o3-toxicity-in-malignantly-transformed-pilocytic-astrocytoma-mpa58-cells-by-activating-caspases-3-7
#2
Monika Primon, Peter C Huszthy, Helena Motaln, Krishna M Talasila, Hrvoje Miletic, Nadia A Atai, Rolf Bjerkvig, Tamara Lah Turnšek
Low-grade, pilocytic astrocytomas are treated by resection, but additional therapy is necessary for those tumors with anaplastic features. Arsenic trioxide (As2O3) is emerging as an effective chemotherapeutic agent for treatment of malignant glioblastoma multiforme, where Cathepsin L silencing enables lower, less harmful As2O3 concentrations to achieve the desired cytotoxic effect. Here, we evaluated the effects of As2O3 combined with stable Cathepsin L shRNA silencing on cell viability/metabolic activity, and apoptosis in primary cultures of recurrent malignantly transformed pilocytic astrocytoma (MPA)...
April 12, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28408259/pediatric-basal-ganglia-region-tumors-clinical-and-radiological-features-correlated-with-histopathological-findings
#3
Wei Fu, Yan Ju, Si Zhang, Chao You
PURPOSE: To summarize the clinical and radiological features of pediatric basal ganglia region tumors (PBGRT) in correlation with their histopathological findings to reduce inappropriate surgery and identify tumors that can benefit from maximal safe resection. METHODS: The records of 35 children with PBGRT treated in our hospital from December 2011 to December 2015 were retrospectively analyzed. The clinical and radiological features of these tumors were summarized in correlated with their histopathological diagnosis...
April 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28394259/a-proangiogenic-signaling-axis-in-myeloid-cells-promotes-malignant-progression-of-glioma
#4
Yujie Huang, Prajwal Rajappa, Wenhuo Hu, Caitlin Hoffman, Babacar Cisse, Joon-Hyung Kim, Emilie Gorge, Rachel Yanowitch, William Cope, Emma Vartanian, Raymond Xu, Tuo Zhang, David Pisapia, Jenny Xiang, Jason Huse, Irina Matei, Hector Peinado, Jacqueline Bromberg, Eric Holland, Bi-Sen Ding, Shahin Rafii, David Lyden, Jeffrey Greenfield
Tumors are capable of coopting hematopoietic cells to create a suitable microenvironment to support malignant growth. Here, we have demonstrated that upregulation of kinase insert domain receptor (KDR), also known as VEGFR2, in a myeloid cell sublineage is necessary for malignant progression of gliomas in transgenic murine models and is associated with high-grade tumors in patients. KDR expression increased in myeloid cells as myeloid-derived suppressor cells (MDSCs) accumulated, which was associated with the transformation and progression of low-grade fibrillary astrocytoma to high-grade anaplastic gliomas...
April 10, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28387849/toca-511-gene-transfer-and-treatment-with-the-prodrug-5-fluorocytosine-promotes-durable-antitumor-immunity-in-a-mouse-glioma-model
#5
Leah A Mitchell, Fernando Lopez Espinoza, Daniel Mendoza, Yuki Kato, Akihito Inagaki, Kei Hiraoka, Noriyuki Kasahara, Harry E Gruber, Douglas J Jolly, Joan M Robbins
Background.: Toca 511 (vocimagene amiretrorepvec) is a retroviral replicating vector encoding an optimized yeast cytosine deaminase (CD). Tumor-selective expression of CD converts the prodrug, 5-fluorocytosine (5-FC), into the active chemotherapeutic, 5-fluorouracil (5-FU). This therapeutic approach is being tested in a randomized phase II/III trial in recurrent glioblastoma and anaplastic astrocytoma (NCT0241416). The aim of this study was to identify the immune cell subsets contributing to antitumor immune responses following treatment with 5-FC in Toca 511-expressing gliomas in a syngeneic mouse model...
April 6, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28384867/vascular-endothelial-growth-factor-as-an-angiogenic-marker-in-malignant-astrocytoma-and-oligodendroglioma-an-indian-scenario
#6
Ramya S Vokuda, Bheemanathi Hanuman Srinivas, Venkatesh S Madhugiri, Surendra Kumar Verma
INTRODUCTION: The role of Vascular Endothelial Growth Factor (VEGF) in angiogenesis has been extensively studied in gliomas, such as astrocytoma and oligodendrogliomas, worldwide. However, there is limited information available with regard to the Indian population. AIM: To study, whether VEGF is expressed in the Indian population in a pattern similar to that in other population. MATERIALS AND METHODS: In this prospective study approved by the Institute Ethics Committee for Human Studies at Jawaharlal Institute of Post Graduate Medical Education and Research (JIPMER) the patients operated for glioma in 2014 and 2015 (n = 60) were included...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28384595/clinical-outcomes-from-maximum-safe-resection-of-primary-and-metastatic-brain-tumors-using-awake-craniotomy
#7
Anastasia Groshev, Devang Padalia, Sephalie Patel, Rosemarie Garcia-Getting, Solmaz Sahebjam, Peter A Forsyth, Frank D Vrionis, Arnold B Etame
OBJECTIVE: To retrospectively analyze outcomes in patients undergoing awake craniotomies for tumor resection at our institution in terms of extent of resection, functional preservation and length of hospital stay. PATIENTS AND METHODS: All cases of adults undergoing awake-craniotomy from September 2012-February 2015 were retrospectively reviewed based on an IRB approved protocol. Information regarding patient age, sex, cancer type, procedure type, location, hospital stay, extent of resection, and postoperative complications was extracted...
March 20, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28378288/development-of-cystic-malacia-after-high-dose-cranial-irradiation-of-pediatric-cns-tumors-in-long-term-follow-up
#8
Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Ikuno Nishibuchi, Hiroshi Kawaguchi, Manish Kolakshyapati, Shumpei Onishi, Taiichi Saito, Kazuhiko Sugiyama, Masao Kobayashi, Kaoru Kurisu
PURPOSE: The purpose of this study is to investigate the incidence of cystic malacia in long-term survivors of pediatric brain tumors treated with high-dose cranial irradiation. MATERIALS AND METHODS: Between 1997 and 2015, we treated 41 pediatric patients (26 males, 15 females; age ranging from 3.3 to 15.7 years, median 9-year-old) of pediatric brain tumors [17 medulloblastomas, 7 primitive neuroectodermal tumors (PNET), 3 pineoblastomas, 6 non-germinomatous germ cell tumors (NGGCT), 8 gliomas (including 4 ependymomas, 1 anaplastic astrocytoma, 1 oligodendroglioma, 1 pilocytic astrocytoma, 1 astroblastoma)] with high-dose craniospinal irradiation...
April 4, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28357536/pediatric-high-grade-glioma-current-molecular-landscape-and-therapeutic-approaches
#9
REVIEW
Steve Braunstein, David Raleigh, Ranjit Bindra, Sabine Mueller, Daphne Haas-Kogan
High-grade pediatric central nervous system glial tumors are comprised primarily of anaplastic astrocytomas (AA, WHO grade III) and glioblastomas (GBM, WHO grade IV). High-grade gliomas are most commonly diagnosed in the primary setting in children, but as in adults, they can also arise as a result of transformation of a low-grade malignancy, though with limited frequency in the pediatric population. The molecular genetics of high-grade gliomas in the pediatric population are distinct from their adult counterparts...
March 29, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/28353668/bevacizumab-for-patients-with-recurrent-gliomas-presenting-with-a-gliomatosis-cerebri-growth-pattern
#10
Michael C Burger, Iris C Mildenberger, Marlies Wagner, Michel Mittelbronn, Joachim P Steinbach, Oliver Bähr
Bevacizumab has been shown to improve progression-free survival and neurologic function, but failed to improve overall survival in newly diagnosed glioblastoma and at first recurrence. Nonetheless, bevacizumab is widely used in patients with recurrent glioma. However, its use in patients with gliomas showing a gliomatosis cerebri growth pattern is contentious. Due to the marked diffuse and infiltrative growth with less angiogenic tumor growth, it may appear questionable whether bevacizumab can have a therapeutic effect in those patients...
March 29, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28353033/a-novel-all-in-one-intraoperative-genotyping-system-for-idh1-mutant-glioma
#11
Fumiharu Ohka, Akane Yamamichi, Michihiro Kurimoto, Kazuya Motomura, Kuniaki Tanahashi, Hiromichi Suzuki, Kosuke Aoki, Shoichi Deguchi, Lushun Chalise, Masaki Hirano, Akira Kato, Yusuke Nishimura, Masahito Hara, Yukinari Kato, Toshihiko Wakabayashi, Atsushi Natsume
IDH1 gene mutation has been demonstrated to be an oncogenic driver in a majority of lower-grade gliomas (LGGs). In contrast to other central nervous neoplasms and normal brain tissue without IDH1 mutation, almost 80% of LGGs exhibit IDH1 mutation. Therefore, expeditious detection of IDH1 mutation is useful, not only for intraoperative diagnosis of these gliomas but also for determination of the border between the tumor and normal brain tissue. In this study, we established a rapid genotyping assay with a simple DNA extraction method, involving only incubation of the tumor specimen with Tris-EDTA buffer, which can be easily performed in an operating room...
March 28, 2017: Brain Tumor Pathology
https://www.readbyqxmd.com/read/28340188/commentary-on-phase-iii-randomized-study-of-radiation-and-temozolomide-versus-radiation-and-nitrosourea-therapy-for-anaplastic-astrocytoma-results-of-nrg-oncology-rtog-9813
#12
https://www.readbyqxmd.com/read/28339043/high-atp2a2-expression-correlates-with-better-prognosis-of-diffuse-astrocytic-tumor-patients
#13
Wei-Qing Li, Nan-Zhe Zhong, Jin He, Yi-Ming Li, Li-Jun Hou, Hui-Min Liu, Chun-Yan Xia, Liang-Zhe Wang, Yi-Cheng Lu
Novel molecular markers are required for defining subsets of diffuse astrocytic tumor patients with differing prognoses. Here, we examined ATP2A2 expression in 109 human diffuse astrocytic tumor samples (39 grade II diffuse astrocytoma (DA), 19 grade III anaplastic astrocytoma (AA), 51 grade IV glioblastoma) and its correlation with patient clinicopathologic characteristics. ATP2A2 expression significantly correlated with tumor grade and survival (P<0.05). High ATP2A2 expression was detected in 35.3% (18/51) of glioblastoma patients, compared to 61...
March 24, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28327577/metabolic-profiling-of-idh-mutation-and-malignant-progression-in-infiltrating-glioma
#14
Llewellyn E Jalbert, Adam Elkhaled, Joanna J Phillips, Evan Neill, Aurelia Williams, Jason C Crane, Marram P Olson, Annette M Molinaro, Mitchel S Berger, John Kurhanewicz, Sabrina M Ronen, Susan M Chang, Sarah J Nelson
Infiltrating low grade gliomas (LGGs) are heterogeneous in their behavior and the strategies used for clinical management are highly variable. A key factor in clinical decision-making is that patients with mutations in the isocitrate dehydrogenase 1 and 2 (IDH1/2) oncogenes are more likely to have a favorable outcome and be sensitive to treatment. Because of their relatively long overall median survival, more aggressive treatments are typically reserved for patients that have undergone malignant progression (MP) to an anaplastic glioma or secondary glioblastoma (GBM)...
March 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28301347/outcomes-for-anaplastic-glioma-treated-with-radiation-therapy-with-or-without-concurrent-temozolomide
#15
Emory McTyre, John T Lucas, Corbin Helis, Michael Farris, Michael Soike, Ryan Mott, Adrian W Laxton, Stephen B Tatter, Glenn J Lesser, Roy E Strowd, Hui-Wen Lo, Waldemar Debinski, Michael D Chan
OBJECTIVES: Postoperative management of anaplastic glioma remains without a clear standard of care-in this study we report outcomes for patients treated with radiotherapy (RT) with and without temozolomide (TMZ). MATERIALS AND METHODS: We identified 71 consecutive patients with World Health Organization grade III glioma treated with either RT alone or with concurrent TMZ (RT+TMZ), between 2000 and 2013. Tumor histology was anaplastic astrocytoma in 42 patients, anaplastic oligodendroglioma in 25 patients, and anaplastic oligoastrocytoma in 4 patients...
March 15, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28288919/a-case-of-therapy-related-acute-myeloid-leukemia-associated-with-adjuvant-temozolomide-chemotherapy-for-anaplastic-astrocytoma
#16
Kenzo Kosugi, Katsuya Saito, Wataru Takahashi, Yukina Tokuda, Hideyuki Tomita
BACKGROUND: Temozolomide (TMZ) is now standard adjuvant therapy in combination with radiotherapy for patients with newly diagnosed malignant glioma. Treatment-related myelodysplastic syndrome (t-MDS) and acute myeloid leukemia (t-AML) associated with TMZ chemotherapy for patients with glioma is quite a rare complication. CASE DESCRIPTION: A 43-year-old man with an anaplastic astrocytoma received radiation therapy synchronized with ranimustine (MCNU) and adjuvant TMZ chemotherapy for 15 cycles...
March 10, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28260920/tbx2-confers-poor-prognosis-in-glioblastoma-and-promotes-temozolomide-resistance-with-change-of-mitochondrial-dynamics
#17
Fuxin Yi, Jianzhou Du, Weimin Ni, Weixian Liu
Tbx2 is a cancer-related protein that was found to be overexpressed in several human malignancies. The present study aims to investigate the clinical significance and biological role of Tbx2 in human astrocytoma. We examined its protein expression in 102 cases of astrocytoma tissues using immunohistochemical staining. Negative Tbx2 staining was observed in normal astrocytes, and positive nuclear staining was found in 41 out of 102 astrocytoma specimens. The rate of Tbx2 overexpression in pylocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, and glioblastoma multiform (GBM) were 0%, 26...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28214203/prognostic-value-of-survivin-and-dna-topoisomerase-ii%C3%AE-in-diffuse-and-anaplastic-astrocytomas
#18
R K Varughese, A J Skjulsvik, S H Torp
Distinguishing WHO grade II astrocytomas from grade III is a difficult task. This study looks into the potential prognostic use of mitotic activity and the proliferation markers Ki67/MiB-1 (Ki67), survivin and DNA topoisomerase IIα (TIIα) in 59 WHO grade II diffuse astrocytomas (DA) and 33 WHO grade III anaplastic astrocytomas (AA), IDH1 R132H-mutated and not otherwise specified (NOS) by means of immunohistochemistry. All proliferation markers showed higher expression in AA compared with DA. Only Ki67 had significantly greater expression in astrocytomas, NOS vs...
January 21, 2017: Pathology, Research and Practice
https://www.readbyqxmd.com/read/28156189/feline-glioma-a-retrospective-study-and-review-of-the-literature
#19
Daniel R Rissi, Andrew D Miller
Case series summary This study aimed to evaluate the pathologic and diagnostic features of 13 cases of feline glioma diagnosed at two veterinary diagnostic institutions over 16 years. A retrospective search was conducted using the laboratory information system. Selected cases were reviewed, tumors were classified according to the 2007 World Health Organization Classification of Tumours of the Central Nervous System, and tissue sections were submitted to an immunohistochemistry panel for further characterization...
February 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28123740/efficacy-of-bevacizumab-therapy-for-unresectable-malignant-glioma-a-retrospective-analysis
#20
Hajime Yonezawa, Hirofumi Hirano, Hiroyuki Uchida, Mika Habu, Ryosuke Hanaya, Tatsuki Oyoshi, Yuko Sadamura, Tomoko Hanada, Hiroshi Tokimura, Fm Moinuddin, Kazunori Arita
Bevacizumab (BEV), an inhibitor of vascular endothelial growth factor A, has been used for primary and recurrent malignant gliomas in Japan since June, 2013. Previous randomized controlled studies demonstrated that BEV prolonged the progression-free survival, but not the overall survival (OS) of patients with newly diagnosed glioblastoma. The aim of the present study was to elucidate the effect of BEV on the OS of patients with unresectable malignant gliomas. Of the 440 cases of malignant glioma initially treated in our institute between 2000 and 2015, 88 were not suitable for maximal resection due to patient age, physical condition, tumor location and extent, or the patient's wishes...
January 2017: Molecular and Clinical Oncology
keyword
keyword
57639
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"