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Andrew D J Pearson, Sara M Federico, Isabelle Aerts, Darren R Hargrave, Steven G DuBois, Robert Iannone, Ryan D Geschwindt, Ruixue Wang, Frank G Haluska, Tanya M Trippett, Birgit Geoerger
PURPOSE: Ridaforolimus is an investigational, potent, selective mTOR inhibitor. This study was conducted to determine the recommended phase 2 dose (RP2D), maximum tolerated dose, safety, pharmacokinetics, and antitumor activity of oral ridaforolimus in children with advanced solid tumors. EXPERIMENTAL DESIGN: In this phase 1, multicenter, open-label study in children aged 6 to <18 years with advanced solid tumors, ridaforolimus was administered orally for 5 consecutive days/week in 28-day cycles until progression, unacceptable toxicity, or consent withdrawal...
October 4, 2016: Oncotarget
Aditya Kumar Gupta, Michael Jones, Kristina Prelog, John Bui, Jacqui Zhu, Anthea Ng, Luciano Dalla-Pozza
Patients with familial/heritable retinoblastoma (RB) are at increased risk of developing second malignancies throughout life, including a pineoblastoma (trilateral RB [TRB]) in early childhood. Current guidelines recommend regular surveillance brain imaging for those with heritable RB until 5 years of age. The presence of pineal cysts has been reported in patients with RB. Pineal cysts are thought to arise due to focal degeneration of the pineal gland and can be found incidentally. The finding of pineal abnormalities including cysts in children with RB on imaging is disconcerting, as it raises the possibility of an underlying malignancy, specifically a pinealoblastoma...
September 30, 2016: Pediatric Hematology and Oncology
David R Raleigh, David A Solomon, Shane A Lloyd, Ann Lazar, Michael A Garcia, Penny K Sneed, Jennifer L Clarke, Michael W McDermott, Mitchel S Berger, Tarik Tihan, Daphne A Haas-Kogan
BACKGROUND: Pineal parenchymal tumors (PPTs) are rare neoplasms of the central nervous system, and data concerning clinical outcomes are limited. The purpose of this study was to define the clinical behavior of PPT according to current histopathologic criteria and identify prognostic factors to guide therapeutic decisions. METHODS: Seventy-five patients treated for PPT at a single institution between 1992 and 2015 were retrospectively identified. Forty-five resection specimens were available and re-reviewed...
June 9, 2016: Neuro-oncology
Jiyong Kwak, Jin-Kyoung Shim, Dong Seok Kim, Ji-Hyun Lee, Junjeong Choi, Junseong Park, Kyoung-Jin Shin, Se-Hoon Kim, Pilnam Kim, Yong-Min Huh, Eui Hyun Kim, Jong Hee Chang, Sun Ho Kim, Seok-Gu Kang
The existence of tumorspheres (TSs) might confer treatment resistance to pineoblastoma (PB). The existence of PB TSs with cellular immortalization potential has not yet been reported. We developed a procedure for isolating TSs from recurrent PB (rPB) and tested whether their properties made them suitable for use as a patient-derived xenograft (PDX). Immunocytochemical staining, RT-PCR and quantitative real-time PCR showed that, among stemness proteins, CD133, musashi and podoplanin were expressed at elevated levels in rPB TSs, but nestin was not...
August 2016: International Journal of Oncology
Tamio Ito, Kenichi Sato, Yoshimaru Ozaki, Taku Asanome, Hirohiko Nakamura, Shinya Tanaka, Taichi Kimura, Hiromi Kanno
INTRODUCTION: In benign pineal parenchymal tumors (PPTs), namely, pineocytoma(PC)and PPT of intermediate differentiation (PPTID), cytologic pleomorphism has occasionally been found;however, it is controversial as to whether the presence of pleomorphic cells leads to upgrading of tumors. We experienced a rare case of pleomorphic PPT in an elderly woman and compared it with a retrospective series of 12 PPTs (PC:3, PPTID:6, pineoblastoma[PB]:3)to evaluate the correlation between pleomorphism and the malignancy grade...
June 2016: No Shinkei Geka. Neurological Surgery
David H Abramson, Brian P Marr, Jasmine H Francis, Ira J Dunkel, Armida W M Fabius, Scott E Brodie, Ijah Mondesire-Crump, Y Pierre Gobin
OBJECTIVE: Report on the 7-year experience with bilateral ophthalmic artery chemosurgery (OAC-Tandem therapy) for bilateral retinoblastoma. DESIGN: Retrospective, single institution study. SUBJECTS: 120 eyes of 60 children with bilateral retinoblastoma treated since March 2008. METHODS: Retrospective review of all children treated at Memorial Sloan Kettering with bilateral ophthalmic artery chemosurgery (Melphalan, Carboplatin, Topotecan, Methotrexate) delivered in the same initial session to both naïve and previously treated eyes...
2016: PloS One
Sara Vila-Bedmar, Bardia Nourbakhsh, Susan Anzalone, Emmanuelle Waubant
No abstract text is available yet for this article.
April 12, 2016: Neurology
Rouzbeh Motiei-Langroudi, Homa Sadeghian, Mohammad Mehdi Soleimani, Amir Saied Seddighi, Sohrab Shahzadi
AIM: Pineal tumors represent uncommon intracranial tumors with highly diverse histologic subtypes. There still exists a controversy in literature about what influences overall survival and outcome. MATERIAL AND METHODS: We present the results of 48 patients with pineal tumor treated either by stereotactic biopsy followed by adjuvant therapy (23 patients) or open surgical resection without (18 patients) or with (7 patients) adjuvant therapy in Shohada Tajrish Hospital, Iran (1993-2008)...
2016: Turkish Neurosurgery
Selma Sirin, Marcus C de Jong, Paolo Galluzzi, Philippe Maeder, Hervé J Brisse, Jonas A Castelijns, Pim de Graaf, Sophia L Goericke
INTRODUCTION: Pineal cysts are a common incidental finding on brain MRI with resulting difficulties in differentiation between normal glands and pineal pathologies. The aim of this study was to assess the size and morphology of the cystic pineal gland in children (0-5 years) and compare the findings with published pineoblastoma cases. METHODS: In this retrospective multicenter study, 257 MR examinations (232 children, 0-5 years) were evaluated regarding pineal gland size (width, height, planimetric area, maximal cyst(s) size) and morphology...
July 2016: Neuroradiology
Paolo Galluzzi, Marcus C de Jong, Selma Sirin, Philippe Maeder, Pietro Piu, Alfonso Cerase, Lucia Monti, Hervé J Brisse, Jonas A Castelijns, Pim de Graaf, Sophia L Goericke
INTRODUCTION: Differentiation between normal solid (non-cystic) pineal glands and pineal pathologies on brain MRI is difficult. The aim of this study was to assess the size of the solid pineal gland in children (0-5 years) and compare the findings with published pineoblastoma cases. METHODS: We retrospectively analyzed the size (width, height, planimetric area) of solid pineal glands in 184 non-retinoblastoma patients (73 female, 111 male) aged 0-5 years on MRI...
July 2016: Neuroradiology
Hirotake Ichise, Akiko Hori, Seiji Shiozawa, Saki Kondo, Yumi Kanegae, Izumu Saito, Taeko Ichise, Nobuaki Yoshida
Temporal genetic modification of mice using the ligand-inducible Cre/loxP system is an important technique that allows the bypass of embryonic lethal phenotypes and access to adult phenotypes. In this study, we generated a tamoxifen-inducible Cre-driver mouse strain for the purpose of widespread and temporal Cre recombination. The new line, named CM32, expresses the GFPneo-fusion gene in a wide variety of tissues before FLP recombination and tamoxifen-inducible Cre after FLP recombination. Using FLP-recombined CM32 mice (CM32Δ mice) and Cre reporter mouse lines, we evaluated the efficiency of Cre recombination with and without tamoxifen administration to adult mice, and found tamoxifen-dependent induction of Cre recombination in a variety of adult tissues...
July 29, 2016: Experimental Animals
Ping Ai, Xingchen Peng, Yong Jiang, Hong Zhang, Shichao Wang, Yuquan Wei
Adult pineoblastomas (PBs) are rare central nervous system tumors. Little is known with regard to the clinical features and outcomes of adult PB, and optimal treatment strategies for adult PB remain to be determined. The current report describes a case of PB in a 46-year-old male, who presented with obstructive hydrocephalus due to a large pineal region mass. Considering the potential effect on quality of life, the patient underwent a partial resection. Postoperative radiotherapy, comprising prophylactic craniospinal irradiation at a dose of 34...
October 2015: Oncology Letters
Noah Hong, Heon Yoo, Sang Hoon Shin, Ho Shin Gwak, Seung Hoon Lee
Radiation therapy has an important role in postoperative treatment of neoplasms originated from central nervous system, but may induce secondary malignancies like as sarcomas, gliomas, and meningiomas. The prognosis of radiation-induced osteosarcomas is known as poor, because they has aggressive nature invasive locally and intractable to multiple treatment strategies like as surgical resection, chemotherapy, and so on. We report a case of radiation-induced osteosarcoma developed from skull after 7 years of craniospinal radiotherapy for pineoblastoma...
October 2015: Brain Tumor Research and Treatment
Jong Hoon Park, Jeong Hoon Kim, Do Hoon Kwon, Chang Jin Kim, Shin Kwang Khang, Young Hyun Cho
OBJECTIVE: Pineal parenchymal tumors (PPTs) in adults are rare, and knowledge regarding their optimal management and treatment outcome is limited. Herein, we present the clinical results of our series of PPTs other than pineoblastomas managed by stereotactic radiosurgery (SRS) at upfront setting. METHODS: Between 1997 and 2014, nine consecutive adult patients with the diagnosis of PPTs, either pineocytoma or pineal parenchymal tumor of intermediate differentiation, were treated with SRS...
October 2015: Journal of Korean Neurosurgical Society
Anthony C Amato-Watkins, Alistair Lammie, Caroline Hayhurst, Paul Leach
Pineal region lesions are uncommon, and pineal parenchymal tumours (PPT) account for 20-30% of tumours in this area of which pineocytomas (PCs) and pineoblastomas (PBs) are more prevalent. In 2007, the World Health Organisation (WHO) reclassified PPT from two subgroups (PC and PB) into four, including pineal parenchymal tumours of intermediate differentiation (PPTID). PPTID have been further divided into low- and high-grade lesions (WHO II and III), but due to their rarity have proven difficult lesions to diagnose and a paucity of literature means their optimal treatment options are a challenge to define...
2016: British Journal of Neurosurgery
Melissa A Gener, Andrew R Conger, Jamie Van Gompel, Mohammad S Ariai, Mark Jentoft, Fredric B Meyer, Jeremy S Cardinal, José M Bonnin, Aaron A Cohen-Gadol
INTRODUCTION: Pineoblastomas are uncommon primitive neuroectodermal tumors that occur mostly in children; they are exceedingly rare in adults. Few published reports have compared the various aspects of these tumors between adults and children. METHODS: The authors report a series of 12 pineoblastomas in adults from 2 institutions over 24 years. The clinical, radiologic, and pathologic features and clinical outcomes were compared with previously reported cases in children and adults...
December 2015: World Neurosurgery
Charles Kulwin, Ken Matsushima, Mahdi Malekpour, Aaron A Cohen-Gadol
Pineal region tumors pose certain challenges in regard to their resection: a deep surgical field, associated critical surrounding neurovascular structures, and narrow operative working corridor due to obstruction by the apex of the culmen. The authors describe a lateral supracerebellar infratentorial approach that was successfully used in the treatment of 10 large (> 3 cm) midline pineal region tumors. The patients were placed in a modified lateral decubitus position. A small lateral suboccipital craniotomy exposed the transverse sinus...
January 2016: Journal of Neurosurgery
Sonia Sandip, Chandan J Das, Rohit Kumar Khandelwal
No abstract text is available yet for this article.
2015: BMJ Case Reports
Zhijun Song, Xiaolei Chen, Yunlin Tang, Lianyin Zhou, Xinguang Yu, Dingbiao Zhou
OBJECTIVE: To explore the efficacies of endoscopic third ventriculostomy (ETV) and tumor biopsy in surgical treatment of obstructive hydrocephalus induced by pineal region tumors. METHODS: For 65 patients of obstructive hydrocephalus induced by pineal region tumors, endoscopic third ventriculostomy (ETV) and tumor biopsy were performed from 2012 to 2014. Tumor specimens were harvested and analyzed histopathologically. According to pathological diagnosis, appropriate treatment strategies were followed...
March 24, 2015: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Asim F Choudhri, Matthew T Whitehead, Adeel Siddiqui, Paul Klimo, Frederick A Boop
BACKGROUND: Diffusion weighted imaging (DWI) has been shown to be helpful in characterizing tumor cellularity, and predicting histology. Several works have evaluated this technique for pineal tumors; however studies to date have not focused on pediatric pineal tumors. OBJECTIVE: We evaluated the diffusion characteristics of pediatric pineal tumors to confirm if patterns seen in studies using mixed pediatric and adult populations remain valid. MATERIALS AND METHODS: This retrospective study was performed after Institutional Review Board approval...
April 2015: Neuroradiology Journal
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