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https://www.readbyqxmd.com/read/27568485/development-of-an-extended-release-formulation-for-apremilast-and-a-level-a-in-vitro-in-vivo-correlation-study-in-beagle-dogs
#1
Meiqiong Tang, Ping Hu, Shigui Huang, Qiang Zheng, Hao Yu, Yun He
The primary objective of the present study was to develop extended-release matrix formulations of apremilast for the oral delivery and to study their in vitro and in vivo correlation. Five extended-release formulations containing hydroxypropylmethylcellulose (HPMC) as the retarding excipient with different release rate of apremilast were prepared. Dissolution tests of all the formulated tablets were performed in water, pH 4.0 and pH 6.8 buffer solutions. The in vitro release kinetics was studied and supported by Korsmeyer-Peppas's equation as it presented highest values of correlation coefficients (r(2) up to 0...
August 26, 2016: Chemical & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27486641/apremilast-otezla-no-progress-in-plaque-psoriasis-or-psoriatic-arthritis
#2
REVIEW
(no author information available yet)
When PUVA therapy and immunosuppressants such as methotrexate are ineffective, TNF alpha antagonists are an option for patients with severe plaque psoriasis, in the absence of a better alternative. This is also the case for patients with psoriatic arthritis after failure of a "disease-modifying" antirheumatic drug. Apremilast, an oral immunosuppressant that inhibits phosphodiesterase type 4, has been authorised in the European Union for use in these settings. In patients with plaque psoriasis, oral apremilast was compared with subcutaneous etanercept, aTNF alpha antagonist, in a randomised, doubleblind, placebo-controlled trial lasting 16 weeks and involving 250 patients in whom other treatments had failed or were inappropriate...
June 2016: Prescrire International
https://www.readbyqxmd.com/read/26629274/otezla-apremilast-an-oral-pde-4-inhibitor-receives-fda-approval-for-the-treatment-of-patients-with-active-psoriatic-arthritis-and-plaque-psoriasis
#3
Loretta Fala
No abstract text is available yet for this article.
March 2015: American Health & Drug Benefits
https://www.readbyqxmd.com/read/26358317/%C3%A2-apremilast-for-psoriasis-and-psoriatic-arthritis
#4
REVIEW
(no author information available yet)
▼ Apremilast (Otezla - Celgene Europe Ltd.) is a novel orally administered immunomodulatory medicine licensed for the treatment of plaque psoriasis and psoriatic arthritis. The company suggests that it has demonstrated proven and durable efficacy in both conditions and has a favourable safety profile with no requirement for drug-specific pre-screening or ongoing laboratory monitoring. Here we review the evidence on the safety and efficacy of apremilast in the management of psoriasis and psoriatic arthritis...
September 2015: Drug and Therapeutics Bulletin
https://www.readbyqxmd.com/read/26243735/apremilast-for-the-treatment-of-psoriasis
#5
REVIEW
Maria Sole Chimenti, Talia Gramiccia, Rosita Saraceno, Luca Bianchi, Virginia Garofalo, Oreste Buonomo, Roberto Perricone, Sergio Chimenti, Andrea Chiricozzi
INTRODUCTION: Psoriasis is a chronic inflammatory skin disease characterized by dysregulation of the immune system and release of pro-inflammatory mediators. Drugs available for psoriasis show some limits as tolerability and route of administration. Apremilast , Otezla®, is an oral small molecule recently approved for the treatment of patients with moderate-to-severe plaque psoriasis. Compared to biologics that target a single cytokine, apremilast, degrading phosphodiesterase 4 (PDE4), interferes with cyclic anti-microbial peptides, which is involved in the transduction of intracellular signals, controlling the balance of pro-inflammatory and anti-inflammatory signals...
2015: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/26236137/apremilast-otezla-a-new-oral-treatment-for-adults-with-psoriasis-and-psoriatic-arthritis
#6
Tina Zerilli, Eric Ocheretyaner
Apremilast (Otezla): A new oral treatment for adults with psoriasis and psoriatic arthritis.
August 2015: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/26220911/apremilast-a-review-in-psoriasis-and-psoriatic-arthritis
#7
REVIEW
Emma D Deeks
Apremilast (Otezla(®)) is an oral phosphodiesterase 4 inhibitor indicated for the twice-daily treatment of adults with psoriasis and psoriatic arthritis (PsA). Its use in these patient populations has been assessed in two phase III clinical trial programmes (ESTEEM and PALACE). At 16 weeks in the two ESTEEM trials, apremilast reduced the severity and extent of moderate to severe plaque psoriasis, including nail, scalp and palmoplantar manifestations, versus placebo in adults, with these benefits generally being sustained over 52 weeks of treatment...
August 2015: Drugs
https://www.readbyqxmd.com/read/25050054/pharmaceutical-approval-update
#8
Marvin M Goldenberg
Apremilast (Otezla) for active psoriatic arthritis, omalizumab (Xolair) for chronic idiopathic urticaria, and grass pollen allergen extract (Oralair) for grass pollen-induced allergic rhinitis with or without conjunctivitis.
June 2014: P & T: a Peer-reviewed Journal for Formulary Management
https://www.readbyqxmd.com/read/24797159/apremilast-first-global-approval
#9
REVIEW
Raewyn M Poole, Anita D Ballantyne
Apremilast (Otezla(®)), an oral small molecule inhibitor of type-4 cyclic nucleotide phosphodiesterase (PDE-4), is under development with Celgene Corporation for the treatment of psoriatic arthritis, psoriasis, ankylosing spondylitis, Behçet's syndrome, atopic dermatitis, and rheumatoid arthritis. Apremilast is indicated for the treatment of active psoriatic arthritis in adults. Apremilast has received its first global approval for this indication in the USA. Regulatory submissions for approval in this indication are under review in Canada and Europe...
May 2014: Drugs
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