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https://www.readbyqxmd.com/read/29160073/synthesis-of-%C3%AE-amino-ketones-by-addition-of-aryl-methyl-ketones-to-sulfinimines-application-to-the-total-synthesis-of-hpa-12-norsedamine-and-sedamine
#1
Arava Amaranadha Reddy, Kavirayani R Prasad
Synthesis of β-sulfinamido ketones is accomplished by the addition of silyl enol ethers derived from arylmethyl ketones to chiral sulfinimines in excellent yield and selectivity. Application of the formed β-amino substituted ketones is exemplified in the total synthesis of sphingolipid HPA-12 and the sedamine alkaloids.
November 21, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/29146060/clinicopathologic-correlation-of-programmed-death-ligand-1-expression-in-non-small-cell-lung-carcinomas-a-report-from-india
#2
Archana George Vallonthaiel, Prabhat Singh Malik, Varsha Singh, Vinay Kumar, Sunil Kumar, Mehar Chand Sharma, Sandeep Mathur, Sudheer Arava, Randeep Guleria, Deepali Jain
INTRODUCTION: Increased expression of Programmed death ligand-1 (PD-L1) on cancer cells and immune cells predict response to PD-1/PDL1 inhibitors. Data regarding frequency and pattern of PD-L1 expression in NSCLC from India is not available. OBJECTIVES: To analyse PD-L1 expression on tumour cells (TC) and immune cells (IC) and to correlate PD-L1 expression with baseline clinico-pathological characteristics, oncogenic drivers and outcome data. MATERIALS AND METHODS: PD-L1 expression on tumour cells and immune cells was analysed...
December 2017: Annals of Diagnostic Pathology
https://www.readbyqxmd.com/read/29132368/frequency-of-canine-nt230-del4-mdr1-mutation-in-prone-pure-breeds-their-crosses-and-mongrels-in-israel-insights-from-a-worldwide-comparative-perspective
#3
Yaron Dekel, Yossy Machluf, Aviad Stoler, Arava Aderet, Daniel Baumel, Efrat Kellerman, Yoram Plotsky, Oshrat Noked Partouche, Gal Elhalal, Izhar Ben-Shlomo, Dani Bercovich
BACKGROUND: Sensitivity to macrocyclic lactones, which are commonly used in veterinary clinics, was first found in Rough Collies, and was attributed in 2001 to a 4 bp deletion in the MDR1 gene. The list of affected breeds currently includes 13 breeds. Researchers from different countries and continents examined the allelic frequencies of the nt230(del4) MDR1 mutation, emphasizing the clinical importance of this test not only to mutation-prone dogs, but also to their crosses and mongrels, since treatment of a deletion carrier with these compounds may lead to its death...
November 13, 2017: BMC Veterinary Research
https://www.readbyqxmd.com/read/29113867/clinical-significance-of-intracoronary-thrombus-aspirated-during-primary-percutaneous-intervention-an-immunohistopathological-study
#4
Neeraj Parakh, Basavaraj Utagi, Sudhir Arava, Sunil Verma, Ganesan Karthikeyan, Sandeep Singh, Balram Bhargava, Ruma Ray, Chetan D Patel, Vinay K Bahl
BACKGROUND: Manual thrombus aspiration during primary percutaneous intervention provides us with aspirated thrombus sample, that may contain material from the disrupted plaque. Immunohistopathological analysis of thrombus can yield valuable information about the clinical and cardiovascular outcomes and possible mechanisms of myocardial infarction. MATERIAL AND METHODS: We studied and analysed the immunohistopathological features of coronary thrombus aspirated from patients undergoing primary percutaneous coronary angioplasty...
September 22, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/29099006/a-26-year-old-man-with-dyspnea-and-chest-pain
#5
Saurabh Mittal, Akanksha Jain, Sudheer Arava, Vijay Hadda, Anant Mohan, Randeep Guleria, Karan Madan
A 26-year-old smoker male presented with a history of sudden onset dyspnea and right-sided chest pain. Chest radiograph revealed large right-sided pneumothorax which was managed with tube thoracostomy. High-resolution computed tomography thorax revealed multiple lung cysts, and for a definite diagnosis, a video-assisted thoracoscopic surgery-guided lung biopsy was performed followed by pleurodesis. This clinicopathologic conference discusses the clinical and radiological differential diagnoses, utility of lung biopsy, and management options for patients with such a clinical presentation...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29098999/tracheobronchial-puncture-site-nodular-reaction-tpnr-following-endobronchial-ultrasound-guided-transbronchial-needle-aspiration-ebus-tbna-systematic-review-of-case-reports
#6
REVIEW
Karan Madan, Pavan Tiwari, Sudheer Arava, Vijay Hadda, Anant Mohan, Randeep Guleria
Endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) is a minimally invasive and efficacious diagnostic modality for lung cancer staging and evaluation of undiagnosed mediastinal lymphadenopathy. Procedure-related complications are uncommon. We herein report an infrequently described phenomenon following EBUS-TBNA in which two patients developed nodular granulation tissue at the tracheobronchial puncture site. On systematic review, we found description of such phenomena by terminologies such as endobronchial inflammatory polyp, granuloma, and endobronchial mass...
November 2017: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29035285/dermoscopy-and-patch-testing-in-patients-with-lichen-planus-pigmentosus-on-face-a-cross-sectional-observational-study-in-fifty-indian-patients
#7
Vinod Kumar Sharma, Vishal Gupta, Piyush Pahadiya, Kamal Kumar Vedi, Sudheer Arava, M Ramam
BACKGROUND: Lichen planus pigmentosus (LPP) is a common cause of facial melanosis in the dark-skinned population. At present, information on dermoscopy and patch testing in LPP is limited. OBJECTIVES: To describe dermoscopic findings and study the role of patch testing in patients with LPP on the face. METHODS: Facial lesions of 50 patients with LPP were studied dermoscopically, followed by histological evaluation. Patch and photopatch tests with the Indian Standard Series and Scandinavian series, respectively, and patient's own cosmetics were performed on all patients...
November 2017: Indian Journal of Dermatology, Venereology and Leprology
https://www.readbyqxmd.com/read/29017841/alternating-histopathological-pattern-in-blaschkoid-dermatoses-with-epidermal-changes-a-retrospective-series-of-61-cases
#8
Vishal Gupta, Sujay Khandpur, Sudheer Arava, M Ramam
No abstract text is available yet for this article.
October 7, 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28971483/study-of-efficacy-and-safety-of-noncultured-extracted-follicular-outer-root-sheath-cell-suspension-transplantation-in-the-management-of-stable-vitiligo
#9
Pawan Kumar, Neetu Bhari, Manoj K Tembhre, Sujata Mohanty, Sudheer Arava, Vinod K Sharma, Somesh Gupta
BACKGROUND: Noncultured, extracted follicular outer root sheath suspension (NC-EHF-ORS-CS) is a recently introduced technique for the treatment of stable vitiligo. OBJECTIVE: To study the clinical efficacy of this technique and to determine the viability and cell composition of the suspension. METHODS: Twenty-five patients with stable vitiligo were included in this prospective study. Fifty follicles were extracted from occipital scalp and were incubated with trypsin-ethylenediaminetetraacetic acid to separate outer root sheath cells...
October 3, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28937365/immunohistochemical-characterization-of-glandular-elements-in-glandular-cardiac-myxoma-study-of-six-cases
#10
Devajit Nath, Sudheer Arava, Ruma Ray, Amol Kumar Bhoje, Rachit Saxena, Shiv Kumar Chaudhary
Back ground: Glandular cardiac myxoma has varying clinical presentation with uncertain histogenesis and debatable immunohistochemical profile. Glandular epithelial differentiations are rare phenomenon known to be present as an intrinsic component of the tumor. The origin of the glands has been attributed to epithelial differentiation of a totipotent cardiomyogenic precursor cells or the entrapped foregut rests in the tumor. MATERIALS AND METHODS: Retrospective study includes six cases of glandular cardiac myxoma collected over a perior of 4 years...
July 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28914958/assessment-of-histopathological-features-of-maculopapular-viral-exanthem-and-drug-induced-exanthem
#11
Sanjay Singh, Sujay Khandpur, Sudheer Arava, Ramashankar Rath, M Ramam, Manoj Singh, Vinod K Sharma, Sushil Kumar Kabra
BACKGROUND: Viral infections and drug reactions are commonest causes of exanthem in clinical practice. Clinically, it may pose a diagnostic challenge due to overlapping features. Hematological, in vitro and drug provocation tests are either not reliable or practical. METHODS: This was a descriptive, prospective study to assess and compare histopathological features of maculopapular viral and drug exanthem. Subjects fulfilling case definition of exanthems were included...
September 15, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28882664/spatial-distribution-of-west-nile-virus-in-humans-and-mosquitoes-in-israel-2000-2014
#12
Yaniv Lustig, Zalman Kaufman, Ella Mendelson, Laor Orshan, Emilia Anis, Yael Glazer, Daniel Cohen, Tamy Shohat, Ravit Bassal
OBJECTIVES: Israel has a long history of West Nile virus (WNV) morbidity, and the rate of detection of WNV in mosquitoes has been high since 2000. The aim of this study was to integrate several WNV datasets in order to gain an insight into the geographical distribution of WNV in Israel. METHODS: Three choropleth maps were generated showing WNV human morbidity, WNV prevalence in mosquitoes, and the results of a nationwide serological survey, based on the division of Israel into 15 sub-districts...
September 4, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/28792176/chikungunya-fever-presenting-as-life-threatening-thrombotic-thrombocytopenic-purpura
#13
Vimal Kumar, Rujul Jain, Arvind Kumar, Neeraj Nischal, Pankaj Jorwal, Manish Soneja, Sudheer Arava, Naveet Wig
It is well known for Chikungunya fever to present as myriad of skin rash along with usual joint pain and fever, but probably this is the first case report of Chikungunya fever presenting as severe life threatening thrombotic microangiopathy, thrombotic thrombocytopenic purpura leading to multiple areas of skin necrosis, peripheral digital gangrene, haemolytic anemia, renal failure and severe thrombocytopenia with bleeding. This complication was most likely due to inhibitor autoantibody formation against ADAMTS13 triggered by chikungunya virus leading to thrombotic thrombocytopenic purpura...
July 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28741750/atypical-morphology-of-anogenital-warts-is-not-a-marker-of-atypical-histology-or-of-infection-to-the-high-risk-human-papillomavirus-genotypes
#14
Pankaj Kumar, Neetu Bhari, Vishal Gupta, V G Ramachandran, Sudheer Arava, Lalit Dar, Vinod K Sharma, Kaushal K Verma, Sada N Dwivedi, Somesh Gupta
BACKGROUND: The clinical morphology of anogenital warts may vary from flat, filiform, papular, or verrucous to giant condyloma acuminatum. Clinically atypical-looking genital warts may alarm the clinician because of their suspected malignant potential, which may cause anxiety, often leading to aggressive interventions. OBJECTIVE: To study if clinically atypical-looking anogenital warts are more likely to be premalignant or malignant as compared to typical warts...
July 25, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28681520/a-hairy-port-wine-stain-with-overlying-hyperhidrosis-on-the-thigh-of-a-child
#15
Vishal Gupta, Saurabh Bhatia, Sudheer Arava, Vinod K Sharma
No abstract text is available yet for this article.
July 6, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/28676799/impact-of-aeolian-dry-deposition-of-reactive-iron-minerals-on-sulfur-cycling-in-sediments-of-the-gulf-of-aqaba
#16
Barak Blonder, Valeria Boyko, Alexandra V Turchyn, Gilad Antler, Uriel Sinichkin, Nadav Knossow, Rotem Klein, Alexey Kamyshny
The Gulf of Aqaba is an oligotrophic marine system with oxygen-rich water column and organic carbon-poor sediments (≤0.6% at sites that are not influenced by anthropogenic impact). Aeolian dust deposition from the Arabian, Sinai, and Sahara Deserts is an important source of sediment, especially at the deep-water sites of the Gulf, which are less affected by sediment transport from the Arava Desert during seasonal flash floods. Microbial sulfate reduction in sediments is inferred from the presence of pyrite (although at relatively low concentrations), the presence of sulfide oxidation intermediates, and by the sulfur isotopic composition of sulfate and solid-phase sulfides...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28612389/biochar-potential-in-intensive-cultivation-of-capsicum-anuum-l-sweet-pepper-crop-yield-and-plant-protection
#17
Abhay Kumar, Yigal Elad, Ludmila Tsechansky, Vikas Abrol, Beni Lew, Rivka Offenbach, Ellen R Graber
BACKGROUND: The influence of various biochars on crop yield and disease resistance of Capsicum anuum L. (sweet pepper) under modern, high-input, intensive net house cultivation was tested over the course of 2011 to 2014 in the Arava desert region of Israel. A pot experiment with Lactuca sativa L. (lettuce) grown in the absence of fertilizer employed the 3-year old field trial soils to determine if biochar treatments contributed to soil intrinsic fertility. RESULTS: Biochar amendments resulted in a significant increase in number and weight of pepper fruits over three years...
June 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28596535/identification-and-characterization-of-roles-for-puf1-and-puf2-proteins-in-the-yeast-response-to-high-calcium
#18
Ofir Haramati, Anastasia Brodov, Idan Yelin, Avigail Atir-Lande, Nitzan Samra, Yoav Arava
Members of the yeast family of PUF proteins bind unique subsets of mRNA targets that encode proteins with common functions. They therefore became a paradigm for post-transcriptional gene control. To provide new insights into the roles of the seemingly redundant Puf1 and Puf2 members, we monitored the growth rates of their deletions under many different stress conditions. A differential effect was observed at high CaCl2 concentrations, whereby puf1Δ growth was affected much more than puf2Δ, and inhibition was exacerbated in puf1Δpuf2Δ double knockout...
June 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28590014/annular-itchy-rash-in-a-woman-with-chronic-pancreatitis
#19
P Sondhi, R Mahajan, S Arava
No abstract text is available yet for this article.
June 7, 2017: Clinical and Experimental Dermatology
https://www.readbyqxmd.com/read/28530056/-cutaneous-leishmaniasis-in-israel-2016-an-update
#20
REVIEW
Michal Solomon, Eli Schwartz
Leishmaniasis is endemic in Israel and is increasing in its frequency. The pathogens that cause cutaneous leishmaniasis (CL) in Israel are Leishmania major (L. major) and Leishmania tropica (L. tropica). In recent years, there have been significant changes in the distribution of these species. L. major is endemic mainly in the Negev, Arava and the Beit She'an Valley. L. tropica is endemic in Tiberias, northern Sea of Galilee, Samaria and in the vicinity of Jerusalem such as at Kfar Adumim, Ma'ale Adumim and Anathoth (north-east of Jerusalem)...
October 2016: Harefuah
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