Read by QxMD icon Read


Takuya Ohba, Mitsue Ishisaka, Saori Tsujii, Kazuhiro Tsuruma, Masamitsu Shimazawa, Koya Kubo, Naofumi Umigai, Takao Iwawaki, Hideaki Hara
Crocetin, the aglycone of crocin, is a carotenoid found in fruits of gardenia (Gardeina jasminoides Ellis) and saffron (Crocus sativus L.). We investigated the protective effects of crocetin against ultraviolet-A (UV-A)-induced skin damage and explored the underlying mechanism. Human skin-derived fibroblasts cells (NB1-RGB) were damaged by exposure to UV-A irradiation (10J/cm(2)). Crocetin protected these cells against cell death and reduced the production of reactive oxygen species induced by UV-A irradiation...
October 15, 2016: European Journal of Pharmacology
Yoshiyuki Hiki, Hideo Hori, Kouichiro Yamamoto, Yoshihiro Yamamoto, Yukio Yuzawa, Nobuya Kitaguchi, Kazuo Takahashi
Increased levels of hypo-galactosylated immunoglobulin (Ig)A1 (HG-IgA1) in IgA nephropathy (IgAN) have been detected using a Helix aspersa agglutinin lectin enzyme-linked immunosorbent assay (ELISA). In this study, we developed monoclonal antibodies to evaluate the HG-IgA1 in IgA nephropathy, aiming to gain a more consistent and reproducible assay. As an analogue to the HG-IgA1 hinge region, a 19 mer synthetic peptide with five GalNAc (sHGP) residues at positions 4, 7, 9, 11 and 15 [VPST(GalNAc)PPT(GalNAc)PS(GalNAc)PS(GalNAc)TPPT (GalNAc)PSPS-NH2] was synthesized...
April 2015: Journal of Nephrology
Toshinori Takagi, Akira Kitashoji, Takao Iwawaki, Kazuhiro Tsuruma, Masamitsu Shimazawa, Shinichi Yoshimura, Toru Iwama, Hideaki Hara
Oxidative stress plays a critical role in mediating tissue injury and neuron death during ischemia-reperfusion injury (IRI). The Keap1-Nrf2 defense pathway serves as a master regulator of endogenous antioxidant defense, and Nrf2 has been attracting attention as a target for the treatment of IRI. In this study, we evaluated Nrf2 expression in IRI using OKD (Keap1-dependent oxidative stress detector) mice and investigated the neuroprotective ability of an Nrf2 activator. We demonstrated temporal changes in Nrf2 expression in the same mice with luciferase assays and an Nrf2 activity time course using Western blotting...
July 2014: Free Radical Biology & Medicine
Aiko Nobusawa, Takaaki Sano, Akihide Negishi, Satoshi Yokoo, Tetsunari Oyama
Diagnosis of the exact grade of oral epithelial dysplasia is difficult, and interobserver variations in grading are common. The aim of this study was to investigate the expression patterns of cytokeratins (CKs) in dysplastic oral epithelia, to identify useful double immunostaining diagnostic markers. Immunoexpression of CK13, CK14, CK17, and Ki-67 were investigated in 21 normal epithelial specimens and 146 epithelial dysplasia specimens. In epithelial dysplasia specimens, orthokeratotic dysplasia (OKD) was identified using CK10 immunostaining...
January 2014: Pathology International
Hesham Mohey, Lise Thibaudin, Blandine Laurent, Francois Berthoux
BACKGROUND: Podocin is a key protein involved in the pathogenesis of steroid-resistant nephrotic syndrome and/or focal segmental glomerulosclerosis (FSGS) and is characterized by a high rate of early recurrence after renal transplantation (RTx) in children and adults. MATERIAL AND METHODS: We studied 206 RTx adult recipients: 187 with a diagnosis of glomerular nephropathy, GN (biopsy-proven in 149, clinical in 38), plus 19 with unknown diagnosis as original kidney disease (OKD), the NPHS2 gene polymorphism, G755A, and correlated with the presence of early recurrence of OKD within the first year (proteinuria over 1 g/day and graft-biopsy proven)...
2013: Annals of Transplantation: Quarterly of the Polish Transplantation Society
Matej Kristan, Ales Leonardis
We propose a new method for a supervised online estimation of probabilistic discriminative models for classification tasks. The method estimates the class distributions from a stream of data in the form of Gaussian mixture models (GMMs). The reconstructive updates of the distributions are based on the recently proposed online kernel density estimator (oKDE). We maintain the number of components in the model low by compressing the GMMs from time to time. We propose a new cost function that measures loss of interclass discrimination during compression, thus guiding the compression toward simpler models that still retain discriminative properties...
March 2014: IEEE Transactions on Cybernetics
Takanori Kobayashi, Satoshi Maruyama, Tatsuya Abé, Jun Cheng, Ritsuo Takagi, Chikara Saito, Takashi Saku
AIMS: We investigated a group of oral mucosal lesions with characteristic hyperorthokeratotic foci, which we termed orthokeratotic dysplasia (OKD), to determine if it could be identified as a distinct histopathological entity. METHODS AND RESULTS: We screened 282 surgical specimens from 200 patients with oral leucoplakia-type squamous cell carcinoma (SCC) or carcinoma in situ (CIS). OKD was defined as an oral mucosal lesional focus in which hyperorthokeratosis was predominant in the presence of the granular cell layer...
November 2012: Histopathology
Junko Aida, Takanori Kobayashi, Takashi Saku, Masatsune Yamaguchi, Naotaka Shimomura, Ken-Ichi Nakamura, Naoshi Ishikawa, Satoshi Maruyama, Jun Cheng, Steven S S Poon, Motoji Sawabe, Tomio Arai, Kaiyo Takubo
OBJECTIVES: A precancerous condition is a lesion that, if left untreated, leads to cancer or can be induced to become malignant. In the oral region, leukoplakia is a lesion that has been regarded as precancerous. In cases of oral carcinoma, we have frequently noticed that a type of leukoplakia histologically demonstrating hyper-orthokeratosis and mild atypia (ortho-keratotic dysplasia; OKD) is often associated with carcinoma, either synchronously or metachronously. Therefore, we consider OKD-type leukoplakia to be a true precancerous lesion...
May 2012: Journal of Oral Pathology & Medicine
José María Peña Porta, Meliton Blasco Oliete, Carmen Vicente de Vera Floristan
OBJECTIVE: To study the prevalence of chronic kidney disease (CKD) [glomerular filtration rate (GFR) <60ml/min/1.73m(2)] and occult kidney disease (OKD) (normal serum creatinine values with GFR <60) in elderly patients. DESIGN: Retrospective, observational study. SETTING: Four primary care centres in the province of Huesca, Spain. PARTICIPANTS: About 4014 patients older than 65 years were randomly selected. MAIN MEASUREMENTS: GFR was calculated for all subjects using the four-variable modified MDRD equation...
November 2009: Atencion Primaria
Manuel M Mota, Shuhei Takemoto, Yuko Takeuchi, Naoki Hara, Kazuyoshi Futai
Comparative studies between Portuguese (T and HF) and Japanese (S10, T4, C14-5 and OKD-1) isolates of the pinewood nematode Bursaphelenchus xylophilus have been made in order to provide information to better understand the possible origin of the Portuguese isolates, recently introduced in the European Union. The main comparative aspects investigated were pathogenicity (seedling mortality ratio), sexual compatibility, and DNA sequences of the rDNA region. Four-year-old Japanese black pine (Pinus thunbergii) seedlings were used as host plants for pathogenicity tests...
December 2006: Journal of Nematology
Sachiko Shimozato, Yoshiyuki Hiki, Hiroko Odani, Kazuo Takahashi, Kouichiro Yamamoto, Satoshi Sugiyama
BACKGROUND: Immunoglobulin A nephropathy (IgAN) is characterized by an aberrant structure of O-glycans in the IgA1 hinge region. Recently, under-galactosylated IgA1 has been found to be increased in Caucasian IgAN patients. Thus, we examined this in Japanese IgAN patients. METHODS: An enzyme-linked immunosorbent assay of binding between Helix aspersa (HAA) and serum IgA was performed in Japanese IgAN patients and the HAA-IgA binding levels were compared among IgAN patients (n = 41), patients with other forms of kidney disease (OKD, n = 43) and healthy controls (n = 38)...
June 2008: Nephrology, Dialysis, Transplantation
Elizabeth T Kiniorski, Sarah K Weider, John R Finley, Erin M Fitzgerald, Jessica C Howard, Peter A Di Nardo, Lawrence T Guzy
UNLABELLED: Sopite syndrome is a disturbance caused by motion characterized by drowsiness and mood changes that may occur without the classic symptoms of motion sickness. Because sopite symptoms are often subtle, it is important to assess for their presence, and to distinguish true sopite symptoms from changes in mood and drowsiness that are due to non-motion related factors such as fatigue and boredom. We compared sopite symptoms in the optokinetic drum (OKD) with symptoms in a control condition in which the drum's motion cues were removed...
October 2004: Aviation, Space, and Environmental Medicine
M J Fisher
No abstract text is available yet for this article.
July 8, 1978: National Underwriter. Life & Health Insurance Edition
C Wallace
No abstract text is available yet for this article.
April 1983: Modern Healthcare
H Zhang, H Kanzaki, K Kawazu
Phenylacetic acid (PA), a phytotoxic product of the bacteria accompanying the virulent nematode isolate OKD-3 was detected in the callus of Pinus thunbergii after inoculation with the nematode. The amount of PA detected was large enough to induced the formation and accumulation of benzoic acid (BA) and its conjugates in the callus. These results further support the hypotheses that PA is the pathogenic toxin and that the PA-producing bacterial strains accompanying the pathogenic nematode are the genuine pathogens of the pine wilt disease...
May 1997: Zeitschrift Für Naturforschung. C, A Journal of Biosciences
K Kawazu, H Zhang, H Yamashita, H Kanzaki
Phenylacetic acid (PA), a toxin produced by three strains of bacteria accompanying the pine wood nematode, Bursaphelenchus xylophilus, was found to be formed in a culture of the nematode. An animal nutrient, nutrient broth (NB) medium, was more suitable for PA production of the accompanying bacteria than a vegetable nutrient, potato sucrose malt extract (PSM) medium. It is presumed that dead nematodes in the PSM medium provided the bacteria with nutrient for PA production. In the culture of virulent isolate OKD-3, more PA was detected than in that of less-virulent isolate OKD-1...
September 1996: Bioscience, Biotechnology, and Biochemistry
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"