Plaid

This research paper explores the impact of social media-based interventions on adolescent reproductive health education, acknowledging the digital residency of today's youth. Utilizing a Solomon Four Group Design, the study assesses the efficacy of tailored interventions on various digital platforms, emphasizing the value, impact, and relevance of innovative educational approaches, particularly those employed by social media. The paper highlights adolescents' pervasive presence on social media, including platforms such as Instagram, Twitter, and Facebook as integral components of their online experiences...

The superior colliculus (SC) is a prominent and conserved visual center in all vertebrates. In mice, the most superficial lamina of the SC is enriched with neurons that are selective for the moving direction of visual stimuli. Here we study how these direction selective neurons respond to complex motion patterns known as plaids, using two-photon calcium imaging in awake male and female mice. The plaid pattern consists of two superimposed sinusoidal gratings moving in different directions, giving an apparent pattern direction that lies between the directions of the two component gratings...

BACKGROUND: Phospholipase Cγ2 (PLCγ2) is an important signaling molecule that receives and transmits signals from various cell surface receptors in most hematopoietic lineages. Variants of PLCG2 cause PLCγ2-associated immune dysregulation (PLAID), a family of conditions that are classified by mutational effect. PLAID with cold urticaria (CU-PLAID) is caused by in-frame deletions of PLCG2 that are dominant negative at physiologic temperatures but become spontaneously active at sub-physiologic temperatures...

No abstract text is available yet for this article.

Spatial, momentum and energy separation of electronic spins in condensed-matter systems guides the development of new devices in which spin-polarized current is generated and manipulated1-3 . Recent attention on a set of previously overlooked symmetry operations in magnetic materials4 leads to the emergence of a new type of spin splitting, enabling giant and momentum-dependent spin polarization of energy bands on selected antiferromagnets5-10 . Despite the ever-growing theoretical predictions, the direct spectroscopic proof of such spin splitting is still lacking...

With the rapid development of smart grids, society has become increasingly urgent to solve the problems of low energy utilization efficiency and high energy consumption. In this context, load identification has become a key element in formulating scientific and effective energy consumption plans and reducing unnecessary energy waste. However, traditional load identification methods mainly focus on known electrical equipment, and accurate identification of unknown electrical equipment still faces significant challenges...

Extracting common patterns of neural circuit computations in the autism spectrum and confirming them as a cause of specific core traits of autism is the first step towards identifying cell- and circuit-level targets for effective clinical intervention. Studies in humans with autism have identified functional links and common anatomical substrates between core restricted behavioral repertoire, cognitive rigidity, and over-stability of visual percepts during visual rivalry. To study these processes with single-cell precision and comprehensive neuronal population coverage, we developed the visual bi-stable perception paradigm for mice based on ambiguous moving plaid patterns consisting of two transparent gratings drifting at an angle of 120°...

How features of complex visual patterns combine to drive perception and eye movements is not well understood. We simultaneously assessed human observers' perceptual direction estimates and ocular following responses (OFR) evoked by moving plaids made from two summed gratings with varying contrast ratios. When the gratings were of equal contrast, observers' eye movements and perceptual reports followed the motion of the plaid pattern. However, when the contrasts were unequal, eye movements and reports during early phases of the OFR were biased toward the direction of the high-contrast grating component; during later phases, both responses more closely followed the plaid pattern direction...

BACKGROUND: Monogenic autoinflammatory diseases (AIDs) are rare inflammatory diseases caused by genetic variants. The pathogenesis is complex and treatment options are limited. This study aimed to describe the safety and efficacy of thalidomide in the treatment of monogenic AIDs. METHODS: This was a single-center, single-arm, real-world study. From September 2016 to August 2021, patients with monogenic AIDs who met the inclusion and exclusion criteria were given thalidomide for 12 months...

BACKGROUND: Pathogenic variants of phospholipase C gamma 2 (PLCG2) cause 2 related forms of autosomal-dominant immune dysregulation (ID), PLCγ2-associated antibody deficiency and immune dysregulation (PLAID) and autoinflammatory PLAID (APLAID). Since describing these conditions, many PLCG2 variants of uncertain significance have been identified by clinical sequencing of patients with diverse features of ID. OBJECTIVE: We sought to functionally classify PLCG2 variants and explore known and novel genotype-function-phenotype relationships...

Eye movements transform a spatial scene into luminance modulations on the retina. Recent work has shown that this transformation is highly structured: within human temporal sensitivity, saccades deliver power that increases in proportion to spatial frequency (SF) up to a critical frequency and remains constant beyond that. Importantly, the critical SF increases with decreasing amplitude. Therefore, at sufficiently low SFs, larger saccades effectively deliver stronger input signals to the retina. Here we tested whether this input reformatting has the predicted perceptual consequences, by examining how large and small saccades (6o & 1o) affect contrast sensitivity...

Ocular following eye movements help stabilize images on the retina and offer a window to study motion interpretation by visual circuits. We use these ocular following eye movements to study motion integration behavior in the marmosets. We characterize ocular following responses in the marmosets using different moving stimuli such as dot patterns, gratings, and plaids. The marmosets can accurately track motion along different directions and exhibit spatial frequency and speed sensitivity that closely matches the sensitivity reported in neurons from their motion selective area MT...

The use of coercion is a common practice in psychiatry despite its deleterious effects and insufficient evidence of benefits. It is so deeply rooted that the mention of establishments that make little use of it arouses a form of incredulity. However, the history of psychiatry and the international literature provide numerous examples of a psychiatry that is hardly coercive and numerous experiences of a reduction in the use of seclusion and/or restraint in psychiatric facilities. Today, in France, there are also less coercive establishments, which, for example, do not use mechanical restraint, have all their units open, or have reduced their use of seclusion and restraint...

In power fingerprint identification, feature information is insufficient when using a single feature to identify equipment, and small load data of specific customers, difficult to meet the refined equipment classification needs. A power fingerprint identification based on the improved voltage-current(V-I) trajectory with color encoding and transferred CBAM-ResNet34 is proposed. First, the current, instantaneous power, and trajectory momentum information are added to the original V-I trajectory image using color coding to obtain a color V-I trajectory image...

Although several biclustering algorithms have been studied, few are used for cross-pattern identification across species using multi-omics data mining. A fast empirical Bayesian biclustering (Bi-EB) algorithm is developed to detect the patterns shared from both integrated omics data and between species. The Bi-EB algorithm addresses the clinical critical translational question using the bioinformatics strategy, which addresses how modules of genotype variation associated with phenotype from cancer cell screening data can be identified and how these findings can be directly translated to a cancer patient subpopulation...

Direction selective neurons in macaque primary visual cortex are narrowly tuned for orientation, and are thus afflicted by the aperture problem. At the next stage of motion processing, in the middle temporal (MT) area, some cells appear to solve this problem, responding to the pattern motion direction of plaids. Models have been proposed to account for this computation, but they do not replicate the diversity of responses observed in MT. We recorded from 386 cells in area MT of two male macaques, while presenting a wide range of random-line stimuli and their compositions into noise plaids...

With the rapid development of artificial intelligence, much more attention has been paid to deep learning. However, as the complexity of learning algorithms increases, the needs of computation power of hardware facilities become more crucial. Instead of the focus being on computing devices like GPU computers, a lightweight learning algorithm could be the answer for this problem. Cross-domain applications of deep learning have attracted great interest amongst researchers in academia and industries. For beginners who do not have enough support with software and hardware, an open-source development environment is very helpful...

No abstract text is available yet for this article.

Nanoconstructs developed for biomedical purposes must overcome diverse biological barriers before reaching the target where playing their therapeutic or diagnostic function. In vivo models are very complex and unsuitable to distinguish the roles plaid by the multiple biological barriers on nanoparticle biodistribution and effect; in addition, they are costly, time-consuming and subject to strict ethical regulation. For these reasons, simplified in vitro models are preferred, at least for the earlier phases of the nanoconstruct development...

High-resolution vision requires fine retinal sampling followed by integration to recover object properties. Importantly, accuracy is lost if local samples from different objects are intermixed. Thus, segmentation, grouping of image regions for separate processing, is crucial for perception. Previous work has used bi-stable plaid patterns, which can be perceived as either a single or multiple moving surfaces, to study this process. Here, we report a relationship between activity in a mid-level site in the primate visual pathways and segmentation judgments...