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https://www.readbyqxmd.com/read/27905499/the-correlation-between-plasma-brain-derived-neurotrophic-factor-and-cognitive-function-in-bipolar-disorder-is-modulated-by-the-bdnf-val66met-polymorphism
#1
Sheng-Yu Lee, Tzu-Yun Wang, Shiou-Lan Chen, Yun-Hsuan Chang, Po-See Chen, San-Yuan Huang, Nian-Sheng Tzeng, Liang-Jen Wang, I Hui Lee, Kao Chin Chen, Yen Kuang Yang, Yi-Hsin Yang, Ru-Band Lu, Cheng-Sheng Chen
We explored the effect of the Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism (rs6265) on correlation between changes in plasma BDNF levels with cognitive function and quality of life (QoL) after 12 weeks of treatment in bipolar disorder (BD). Symptom severity and plasma BDNF levels were assessed upon recruitment and during weeks 1, 2, 4, 8 and 12. QoL, the Wisconsin Card Sorting Test (WCST), and the Conners' Continuous Performance Test (CPT) were assessed at baseline and endpoint. The BDNF Val66Met polymorphism was genotyped...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27904636/effect-of-cognitive-behavioral-stress-management-program-on-psychosomatic-patients-quality-of-life
#2
Zahra Ghazavi, Esmat Rahimi, Mohsen Yazdani, Hamid Afshar
BACKGROUND: Level of stress and its management affects the dimensions of psychosomatic patients' quality of life (QoL), which is an important psychological issue. The present study aimed to investigate the effect of cognitive behavioral stress management program on psychosomatic patients' QoL. In cognitive behavioral method, patients discover thought and behavioral mistakes and recover them. The criterion to evaluate the success of the present study was measurement of the patients' QoL and its notable improvement after intervention...
September 2016: Iranian Journal of Nursing and Midwifery Research
https://www.readbyqxmd.com/read/27902979/altered-systemic-adipokines-in-patients-with-chronic-urticaria
#3
Hoang Kim Tu Trinh, Duy Le Pham, Ga-Young Ban, Hyun-Young Lee, Hae-Sim Park, Young-Min Ye
BACKGROUND: Increasing evidence suggests that adipokines affect immune responses and chronic urticaria (CU) is associated with an altered immune response related to chronic systemic inflammation. Our objectives were to investigate whether adipokines are involved in CU pathogenesis and to outline relationships between adipokines and urticaria severity and quality of life. METHODS: Serum adiponectin, leptin, lipocalin-2 (LCN2), interleukin (IL)-10, IL-6, and tumor necrosis factor (TNF)-α concentrations were measured by enzyme-linked immunosorbent assays in 191 CU patients and 89 healthy controls...
December 1, 2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27902557/stiffness-after-pan-lumbar-arthrodesis-for-adult-spinal-deformity-does-not-significantly-impact-patient-functional-status-or-satisfaction-irrespective-of-proximal-endpoint
#4
Robert A Hart, Jayme Hiratzka, Marie S Kane, Virginie Lafage, Eric Klineberg, Christopher P Ames, Breton G Line, Frank Schwab, Justin K Scheer, Shay Bess, D Kojo Hamilton, Christopher I Shaffrey, Greg Mundis, Justin S Smith, Douglas C Burton, Daniel M Sciubba, Vedat Deviren, Oheneba Boachie-Adjei
STUDY DESIGN: Prospective, multi-center OBJECTIVE.: To determine if stiffness significantly affects function or satisfaction after pan-lumbar arthrodesis. SUMMARY OF BACKGROUND DATA: The Lumbar Stiffness Disability Index (LSDI) is a validated measure of the effect of lumbar stiffness on functional activities. Data suggests that patients undergoing fusion of the entire lumbar spine are at greatest risk of functional limitations from stiffness. METHODS: The LSDI, Short Form 36 (SF-36), Scoliosis Research Society-22 (SRS-22), and Oswestry Disability Index (ODI) were administered pre-operatively and at 2-year minimum follow-up to 103 spinal deformity patients from 11 centers...
November 29, 2016: Spine
https://www.readbyqxmd.com/read/27901518/life-events-substance-use-psychological-distress-and-quality-of-life-in-male-and-female-french-gamblers
#5
Ce Line Bonnaire, Vivianne Kovess, Romain Guignard, Jean-Baptiste Richard, Enguerrand Du-Roscoat, Franc Ois Beck
BACKGROUND: Most studies on substance use, psychological distress, quality of life (QoL), and life events among gamblers are carried out on pathological gamblers seeking treatment, and sex differences are rarely investigated. The aim of this study was to explore the potential male-female differences in the relationship between these variables in a nationally representative French sample. METHODS: Three hundred thirty-two problem gamblers (PGs) and 25,314 non-problem gamblers or non-gamblers (NPGs) were evaluated for sociodemographic variables, gambling behavior, substance use, QoL, and life events...
November 2016: Annals of Clinical Psychiatry: Official Journal of the American Academy of Clinical Psychiatrists
https://www.readbyqxmd.com/read/27901493/has-aidi-injection-the-attenuation-and-synergistic-efficacy-to-gemcitabine-and-cisplatin-in-non-small-cell-lung-cancer-a-meta-analysis-of-36-randomized-controlled-trials
#6
Zheng Xiao, Chengqiong Wang, Ling Chen, Xuemei Tang, Lianhong Li, Nana Li, Jing Li, Qihai Gong, Fushan Tang, Jihong Feng, Xiaofei Li
Gemcitabine and cisplatin is the first line chemotherapy for non-small cell lung cancer with high toxicity. Aidi injection is a cantharidin and astragalu-based Chinese herbs injection in China. Has Aidi injection attenuation and synergistic efficacy to GP in NSCLC? There is lack of strong evidence to prove it. To further reveal it, we systematically evaluated all related studies. We collected all studies about Aidi injection plus GP for NSCLC in Medline, Embase, Web of Science, CNKI, VIP, Wanfang Database, CBM, CCRCT, Chi-CTR, and US-clinical trials (established to June 2015)...
November 25, 2016: Oncotarget
https://www.readbyqxmd.com/read/27901330/critically-ill-octogenarians-and-nonagenarians-evaluation-of-long-term-outcomes-post-hospital-trajectories-and-quality-of-life-one-year-and-seven-years-after-icu-discharge
#7
Sandra Oeyen, Joris Vermassen, Ruth Piers, Dominique Benoit, Lieven Annemans, Johan Decruyenaere
BACKGROUND: To investigate long-term outcomes, post-hospital trajectories, and quality of life (QOL) in patients ≥ 80 years admitted to the intensive care unit (ICU) of a tertiary care hospital. METHODS: A 1-year prospective observational cohort analysis was performed. All consecutive patients ≥ 80 years admitted to the ICU were screened for inclusion. Demographics, comorbidity, organ failures, and outcomes were analyzed. QOL before admission, 3 months, 1 year, and 7 years after ICU discharge was assessed using EuroQoL-5D (EQ-5D) and Medical Outcomes Study 36-item Short Form Health Survey (SF-36) questionnaires...
November 30, 2016: Minerva Anestesiologica
https://www.readbyqxmd.com/read/27901287/randomized-trial-of-roux-en-y-gastric-bypass-versus-sleeve-gastrectomy-in-achieving-excess-weight-loss
#8
M Ignat, M Vix, I Imad, A D'Urso, S Perretta, J Marescaux, D Mutter
BACKGROUND: Robust data on quality of life (QoL) after different techniques of bariatric surgery are sparse. This RCT compared excess weight loss (EWL) and QoL after sleeve gastrectomy versus Roux-en-Y gastric bypass (RYGB). METHODS: Obese patients were assigned randomly to RYGB or sleeve gastrectomy. The primary outcome measure was EWL. Secondary outcomes included QoL, co-morbidity, adverse events, vitamin and glycolipid status. QoL was assessed before and annually after surgery, using the Moorehead-Ardelt Quality of Life Questionnaire II (M-A-QoLQII) and Gastrointestinal Quality of Life Index (GIQLI)...
November 30, 2016: British Journal of Surgery
https://www.readbyqxmd.com/read/27901257/brazilian-portuguese-translation-cross-cultural-adaptation-and-validation-of-the-myasthenia-gravis-composite-scale-a-multicentric-study
#9
Ezequiel Fernandes Oliveira, Valéria Cavalcante Lima, Eduardo Araujo Perez, Melissa Nunes Polaro, Berenice Cataldo Oliveira Valério, João R Pereiro, Sergio Roberto Nacif, Claudia Santos Oliveira, Acary Souza Bulle Oliveira, Luis Vicente Franco Oliveira
Objective: To perform the translation, cultural adaptation and validation of the Myasthenia Gravis Composite (MGC) scale in Brazil. Methods: The study was conducted at three neuromuscular disease research centers in accordance with the international ethical standards, following a multi-modal approach and was conducted in three steps consisting of translation, cultural adaptation, and validation according to international guidelines. The final version of the MGC was applied in a sample of 27 MG patients and the total score was compared to a Portuguese version of the MG-QOL-15...
November 2016: Arquivos de Neuro-psiquiatria
https://www.readbyqxmd.com/read/27901246/chemotherapy-for-advanced-non-small-cell-lung-cancer-in-the-elderly-population
#10
Fábio Nasser Santos, Tiago Biachi de Castria, Marcelo Rocha Souza Cruz, Rachel Riera
BACKGROUND: Approximately 50% of patients with newly diagnosed non-small cell lung cancer (NSCLC) are over 70 years of age at diagnosis. Despite this fact, these patients are underrepresented in randomized controlled trials (RCTs). As a consequence, the most appropriate regimens for these patients are controversial, and the role of single-agent or combination therapy is unclear. In this setting, a critical systematic review of RCTs in this group of patients is warranted. OBJECTIVES: To assess the effectiveness and safety of different cytotoxic chemotherapy regimens for previously untreated elderly patients with advanced (stage IIIB and IV) NSCLC...
September 2016: São Paulo Medical Journal, Revista Paulista de Medicina
https://www.readbyqxmd.com/read/27900546/validation-of-the-chinese-version-of-functional-assessment-of-anorexia-cachexia-therapy-faact-scale-for-measuring-quality-of-life-in-cancer-patients-with-cachexia
#11
Ting Zhou, Kaixiang Yang, Sudip Thapa, Qiang Fu, Yongsheng Jiang, Shiying Yu
PURPOSE: The assessment of quality of life (QOL) is an important part of cachexia management for cancer patients. Functional assessment of anorexia-cachexia therapy (FAACT), a specific QOL instrument for cachexia patients, has not been validated in Chinese population. The aim of this study was to validate the FAACT scale in Chinese cancer patients for its future use. METHODS: Eligible cancer patients were included in our study. Patients' demographic and clinical characteristics were collected from the electronic medical records...
November 29, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/27900196/muscle-function-is-associated-with-future-patient-reported-outcomes-in-young-adults-with-acl-injury
#12
Vala Flosadottir, Ewa M Roos, Eva Ageberg
BACKGROUND/AIM: Consequences of an anterior cruciate ligament (ACL) injury include worse patient-reported outcomes (PROs) and a decrease in activity level. Muscle function can be improved by targeted exercise. Our aims were to investigate cross-sectional and longitudinal associations among lower extremity muscle function and PROs after ACL injury. METHODS: Fifty-four participants (15 women, mean 30 years) with ACL injury or reconstruction, from the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) trial (ISRCTN84752559), were assessed with hop performance, muscle power and postural orientation 3 years (SD 0...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27899781/-two-cases-of-unresectable-advanced-gallbladder-cancer-in-which-gemcitabine-and-cisplatin-therapy-improved-the-qol
#13
Hideki Nagano, Shingo Yoshioka, Masayuki Sato, Hiroki Kaida, Keisuke Handa, Ryoji Watanabe, Akira Tomita
We encountered 2 patients with unresectable advanced gallbladder cancer whose performance status improved within a short time following the administration of gemcitabine and cisplatin. Both patients were able to maintain a good QOL while continuing treatment.
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27899433/can-we-help-care-providers-communicate-more-effectively-with-persons-having-dementia-living-in-long-term-care-homes
#14
Katherine S McGilton, Elizabeth Rochon, Souraya Sidani, Alexander Shaw, Boaz M Ben-David, Marianne Saragosa, Veronique M Boscart, Rozanne Wilson, Karmit K Galimidi-Epstein, M Kathleen Pichora-Fuller
BACKGROUND: Effective communication between residents with dementia and care providers in long-term care homes (LTCHs) is essential to resident-centered care. PURPOSE: To determine the effects of a communication intervention on residents' quality of life (QOL) and care, as well as care providers' perceived knowledge, mood, and burden. METHOD: The intervention included (1) individualized communication plans, (2) a dementia care workshop, and (3) a care provider support system...
November 28, 2016: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/27899312/exploratory-factor-analysis-of-nrg-oncology-s-university-of-washington-quality-of-life-questionnaire-rtog-modification
#15
Stephanie L Pugh, Gwen Wyatt, Raimond K W Wong, Stephen M Sagar, Bevan Yueh, Anurag K Singh, Min Yao, Phuc Felix Nguyen-Tan, Sue S Yom, Francis S Cardinale, Khalil Sultanem, D Ian Hodson, Greg A Krempl, Ariel Chavez, Alexander M Yeh, Deborah W Bruner
CONTEXT: The 15-item University of Washington Quality of Life questionnaire - Radiation Therapy Oncology Group (RTOG) modification (UW-QOL-RTOG modification) has been used in several trials of head and neck cancer conducted by NRG Oncology such as RTOG 9709, RTOG 9901, RTOG 0244, and RTOG 0537. OBJECTIVES: This study is an exploratory factor analysis (EFA) to establish validity and reliability of the instrument subscales. METHODS: EFA on the UW-QOL - RTOG modification was conducted using baseline data from NRG Oncology's RTOG 0537, a trial of acupuncture-like transcutaneous electrical nerve stimulation in treating radiation-induced xerostomia...
November 26, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/27899002/in-axial-spondyloarthritis-never-smokers-ex-smokers-and-current-smokers-show-a-gradient-of-increasing-disease-severity-results-from-the-scotland-registry-for-ankylosing-spondylitis-siras
#16
Gareth T Jones, Tiara Ratz, Linda E Dean, Gary J Macfarlane, Fabiola Atzeni
Objectives To examine the relationship between smoking, smoking cessation, and disease characteristics/quality of life (QoL) in spondyloarthritis. Methods The Scotland Registry for Ankylosing Spondylitis collects data from clinically diagnosed patients with spondyloarthritis. Clinical data, including Bath Ankylosing Spondylitis indices of disease activity (BASDAI) and function (BASFI), was obtained from medical records. Postal questionnaires provided information on smoking status and QoL (Ankylosing Spondylitis QoL questionnaire; ASQoL)...
November 29, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27898680/a-core-outcome-set-for-the-benefits-and-adverse-events-of-bariatric-and-metabolic-surgery-the-bariact-project
#17
Karen D Coulman, James Hopkins, Sara T Brookes, Katy Chalmers, Barry Main, Amanda Owen-Smith, Robert C Andrews, James Byrne, Jenny L Donovan, Graziella Mazza, Barnaby C Reeves, Chris A Rogers, Janice L Thompson, Richard Welbourn, Sarah Wordsworth, Jane M Blazeby
BACKGROUND: Bariatric and metabolic surgery is used as a treatment for patients with severe and complex obesity. However, there is a need to improve outcome selection and reporting in bariatric surgery trials. A Core Outcome Set (COS), an agreed minimum set of outcomes reported in all studies of a specific condition, may achieve this. Here, we present the development of a COS for BARIAtric and metabolic surgery Clinical Trials-the BARIACT Study. METHODS AND FINDINGS: Outcomes identified from systematic reviews and patient interviews informed a questionnaire survey...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27898181/endovenous-ablation-therapy-laser-or-radiofrequency-or-foam-sclerotherapy-versus-conventional-surgical-repair-for-short-saphenous-varicose-veins
#18
REVIEW
Sharath Chandra Vikram Paravastu, Margaret Horne, P Dominic F Dodd
BACKGROUND: Short (or small) saphenous vein (SSV) varices occur as a result of an incompetent sapheno-popliteal junction, where the SSV joins the popliteal vein, resulting in reflux in the SSV; they account for about 15% of varicose veins. Untreated varicose veins may sometimes lead to ulceration of the leg, which is difficult to manage. Traditionally, treatment was restricted to surgery or conservative management. Since the 1990s, however, a number of minimally invasive techniques have been developed; these do not normally require a general anaesthetic, are day-case procedures with a quicker return to normal activities and avoid the risk of wound infection which may occur following surgery...
November 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27897994/disability-physical-inactivity-and-impaired-health-related-quality-of-life-are-not-different-in-metabolically-healthy-vs-unhealthy-obese-subjects
#19
Lorenzo M Donini, Gianluca Merola, Eleonora Poggiogalle, Carla Lubrano, Lucio Gnessi, Stefania Mariani, Silvia Migliaccio, Andrea Lenzi
BACKGROUND: Obesity represents a major health hazard, affecting morbidity, psychological status, physical functionality, quality of life, and mortality. The aim of the present study was to explore the differences between metabolically healthy (MHO) and metabolically unhealthy (MUO) obese subjects with regard to physical activity, disability, and health-related quality of life (HR-QoL). METHODS: All subjects underwent a multidimensional evaluation, encompassing the assessment of body composition, metabolic biomarkers and inflammation, physical activity level (IPAQ questionnaire), disability (TSD-OC test), and HR-QoL (SF-36 questionnaire)...
November 25, 2016: Nutrients
https://www.readbyqxmd.com/read/27897372/azelaic-acid-20%C3%A2-cream-effects-on-quality-of-life-and-disease-severity-in-adult-female-acne-patients
#20
Julius Thomas Kainz, Gabriele Berghammer, Piet Auer-Grumbach, Verena Lackner, Sylvia Perl-Convalexius, Rodica Popa, Barbara Wolfesberger
BACKGROUND: Data on the efficacy of acne treatments and their impact on quality of life (QoL) in adult patients is sketchy. OBJECTIVE: Assessment of the efficacy of azelaic acid 20 % cream (Skinoren(®) ) on acne severity and disease-related QoL. PATIENTS AND METHODS: Noninterventional study in adult female patients with mild to moderate acne. Efficacy variables included DLQI and acne severity on the face, chest, and back using the Investigator's Global Assessment (IGA) scale (grade 1 = nearly clear skin; 2 = mild acne; 3 = moderate acne)...
November 29, 2016: Journal der Deutschen Dermatologischen Gesellschaft, Journal of the German Society of Dermatology: JDDG
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