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https://www.readbyqxmd.com/read/29570182/-surgical-treatment-of-primary-liver-malignancies
#1
Attila Szijártó, András Fülöp
The incidence of primary malignant liver tumours is globally rising. Hepatocellular carcinoma constitutes 75-85% of primary liver malignancies. Owing to advancements of oncological therapies, several methods are available to combat the tumour. Upon the complexity of the disease and the wide spectrum of therapeutical regimens, therapy of HCC is debated, with several undecided issues. Noteworthy, however, is that in early tumour stages, as a de facto curative approach, surgical therapy remains the most effective, allowing long-term survival...
March 23, 2018: Magyar Onkologia
https://www.readbyqxmd.com/read/29509246/downregulation-of-copb2-by-rnai-inhibits-growth-of-human-cholangiocellular-carcinoma-cells
#2
Z-S Li, C-H Liu, Z Liu, C-L Zhu, Q Huang
OBJECTIVE: The present study aimed to explore the contribution of COPB2 (coatomer subunit beta) towards the tumorigenesis of cholangiocellular carcinomas and to elucidate the underlying mechanism(s). MATERIALS AND METHODS: Expression of COPB2 mRNA by RBE and QBC939 cholangiocellular carcinoma cell lines was determined by qRT-PCR. We, then, silenced COPB2 expression in RBE cells by infection with a COPB2-siRNA lentivirus and measured the proliferation, cell-cycle distribution, and apoptosis of transduced cells...
February 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29483499/multiple-field-interstitial-photodynamic-therapy-of-subcutaneously-transplanted-cholangiocellular-carcinoma-rs-1-in-rats
#3
D A Tzerkovsky
The aim of present study was to investigate an antitumor efficacy of multiple-field interstitial photodynamic therapy (iPDT) in vivo. MATERIALS AND METHODS: The study was performed on 15 white random-bred rats with subcutaneously transplanted cholangiocellular carcinoma RS-1. Chlorine-based photosensitizer (PS) Ce6CPPPS was administered via single injection at a dose of 2.5 mg/kg into the animal's caudal vein. Photoirradiation (PI) of tumors was carried out 3 h after PS administration using 7 optical fibers SMA-905 with diode laser with 660 ± 5 nm wavelength at exposure doses of 150 and 300 J/cm² with 0...
July 2017: Experimental Oncology
https://www.readbyqxmd.com/read/29482629/primary-carcinosarcoma-of-the-liver-imaging-features-and-clinical-findings-in-six-cases-and-a-review-of-the-literature
#4
Jing Li, Pan Liang, Dandan Zhang, Jie Liu, Hongkai Zhang, Jinrong Qu, Jianbo Gao
BACKGROUND: Carcinosarcoma of the liver is a very rare tumor composed of a mixture of carcinomatous and sarcomatous elements. Less than 25 adequately documented cases have been reported, with inadequate description of imaging features. In order to improve the awareness of this rare tumor, this study aimed to analyze the clinicopathologic and imaging features of six cases of hepatic carcinosarcoma (HCS) confirmed by surgical pathologic evaluation. METHODS: We retrospectively studied the clinicopathologic and imaging features of six cases of HCS (matching the World Health Organization definition) and discussed the differential diagnosis on the basis of imaging findings...
February 27, 2018: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
https://www.readbyqxmd.com/read/29476594/compartment-model-analysis-of-intravenous-contrast-enhanced-dynamic-computed-tomography-in-hepatic-hemodynamics-a-validation-study-using-intra-arterial-contrast-enhanced-computed-tomography
#5
Daisuke Komatsu, Akira Yamada, Takeshi Suzuki, Masahiro Kurozumi, Yasunari Fujinaga, Kazuhiko Ueda, Masumi Kadoya
AIM: To verify the utility of the 2-in-1-out-compartment model analysis (CMA) of intravenous contrast-enhanced dynamic computed tomography (IV-CT) for evaluating hepatic arterial and portal venous flow using intra-arterial contrast-enhanced CT (IA-CT). METHODS: We retrospectively evaluated 49 consecutive patients who underwent IV-CT and were radiologically or histologically diagnosed as having hepatic malignant lesion (51 classical hepatocellular carcinomas [HCC], 4 early HCC, 3 cholangiolocellular carcinomas, 1 mixed HCC, 3 cholangiocellular carcinomas)...
February 23, 2018: Hepatology Research: the Official Journal of the Japan Society of Hepatology
https://www.readbyqxmd.com/read/29470630/modified-ante-situm-liver-resection-without-use-of-cold-perfusion-nor-veno-venous-bypass-for-treatment-of-hepatic-lesions-infiltrating-the-hepatocaval-confluence
#6
F Oldhafer, K I Ringe, K Timrott, M Kleine, O Beetz, W Ramackers, S Cammann, J Klempnauer, F W R Vondran, H Bektas
PURPOSE: Treatment of malignancies invading the hepatic veins/inferior vena cava is a surgical challenge. An ante situm technique allows luxation of the liver in front of the situs to perform tumor resection. Usually, cold perfusion and veno-venous bypass are applied. Our experience with modified ante situm resection relying only on total vascular occlusion is reported. METHODS: Retrospective analysis on an almost 15-year experience with ante situm resection without application of cold perfusion or veno-venous bypass RESULTS: The ante situm technique was applied on eight patients...
February 22, 2018: Langenbeck's Archives of Surgery
https://www.readbyqxmd.com/read/29460044/mri-features-of-primary-hepatic-lymphoma
#7
Stefano Colagrande, Linda Calistri, Giulia Grazzini, Cosimo Nardi, Simone Busoni, Giovanni Morana, Luigi Grazioli
PURPOSE: Our retrospective study sought to describe the spectrum of magnetic resonance imaging (MRI) features of primary hepatic lymphoma (PHL) by analyzing its morphological aspects, signal intensity before and after contrast agent (CA) administration, and diffusion-weighted imaging (DwI) with the apparent diffusion coefficient (ADC) values. METHODS: A retrospective analysis was conducted on 25 patients with pathologically proven PHL who underwent MRI between January 2011 and December 2016...
February 19, 2018: Abdominal Radiology
https://www.readbyqxmd.com/read/29454647/dynamic-plasticity-of-macrophage-functions-in-diseased-liver
#8
Thomas Ritz, Oliver Krenkel, Frank Tacke
Liver macrophages attract increasing interest due to their crucial roles in homeostasis and hepatic diseases. Recent findings in mice and man suggest a remarkable phenotypic and functional diversity of liver macrophages. Kupffer cells, the subset of tissue resident macrophages with sentinel functions in liver, mainly arise from embryogenic precursors, whereas in injury, liver tissue is engrafted by monocyte-derived macrophages. Both principal macrophage populations respond to local or systemic signals and have substantial effects on reduction as well as aggravation of hepatic diseases...
December 20, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/29394788/-a-case-report-of-an-elderly-patient-s-intrahepatic-cholangiocellular-carcinoma-with-cholangitis
#9
Hiroshi Ito, Toshiya Ochiai, Hiroki Nakatsuji, Hiroyuki Inoue, Nobuyuki Watanabe, Atsushi Yoshiyama, Atsushi Toma, Kenji Nakamura, Eigo Otsuji
We report a case of an elderly patient diagnosed with intrahepatic cholangiocellular carcinoma with cholangitis.An 88- year-old woman presented with fever.Computed tomography examination showed a hepatic tumor and dilation of the peripheral bile duct.Cholangiocarcinoma was diagnosed.Biliary tract drainage and palliative care were suggested because of her age.However, her family asked for a second opinion about operative management and consulted our hospital.Radical operations for intrahepatic cholangiocellular carcinoma that has spread to the left lobe are usually accompanied by widespread lymph node dissection and extensive hepatectomy with biliary tract reconstruction...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29359023/primary-biliary-cholangitis-metachronously-complicated-with-combined-hepatocellular-carcinoma-cholangiocellular-carcinoma-and-hepatocellular-carcinoma
#10
Ryuta Ide, Akihiko Oshita, Takashi Nishisaka, Hideki Nakahara, Shiomi Aimitsu, Toshiyuki Itamoto
Primary biliary cholangitis (PBC) is a progressive cholestatic liver disease characterized by the presence of highly specific antimitochondrial antibodies, portal inflammation and lymphocyte-dominated destruction of the intrahepatic bile ducts, which leads to cirrhosis. While its pathogenesis remains unclear, PBC that shows histological progression to fibrosis carries a high risk of carcinogenesis; the same is true of viral liver diseases. In patients with PBC, the development of hepatocellular carcinoma (HCC) is rare; the development of combined hepatocellular carcinoma and cholangiocellular carcinoma (cHCC-CCC) is extraordinary...
December 28, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/29282035/somatostatin-and-cxcr4-chemokine-receptor-expression-in-hepatocellular-and-cholangiocellular-carcinomas-tumor-capillaries-as-promising-targets
#11
Daniel Kaemmerer, Robin Schindler, Franziska Mußbach, Uta Dahmen, Annelore Altendorf-Hofmann, Olaf Dirsch, Jörg Sänger, Stefan Schulz, Amelie Lupp
BACKGROUND: Hepatocellular (HCC) and cholangiocellular carcinomas (CCC) display an exceptionally poor prognosis. Especially for advanced disease no efficient standard therapy is currently available. Recently, somatostatin analogs have been evaluated for the treatment of HCC, however, with contradictory results. Besides, for both malignancies the chemokine receptor CXCR4 has been discussed as a possible new target structure. METHODS: Expression of somatostatin receptor (SSTR) subtypes 1, 2A, 3, 4, and 5, and of CXCR4 was evaluated in a total of 71 HCCs and 27 CCCs by immunohistochemistry using well-characterized novel monoclonal antibodies...
December 28, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29233685/contrast-enhanced-ultrasound-in-mixed-hepatocellular-cholangiocarcinoma-case-series-and-review-of-the-literature
#12
Yi Dong, Andreas Teufel, Jörg Trojan, Annalisa Berzigotti, Xin Wu Cui, Christoph F Dietrich
BACKGROUND: Mixed hepatocellular cholangiocarcinoma is a rare form of primary liver cancer. AIMS: The aim of this study is to report the results of the use of contrast enhanced ultrasound in a series of patients with confirmed mixed hepatocellular cholangiocarcinoma and to provide an updated literature review. METHODS: Between January 2012 and October 2016, 25 Asian patients with confirmed mixed hepatocellular cholangiocarcinoma were included in this bicentric retrospective analysis...
November 24, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/29199665/metastasectomy-for-recurrent-or-metastatic-biliary-tract-cancers-a-single-center-experience
#13
I Park, Y S Kim, S J Sym, H K Ahn, K K Kim, Y H Park, J N Lee, D B Shin
PURPOSE: To assess efficacy or long-term result of metastasectomy for recurrent or metastatic biliary tract carcinoma (BTC), we conducted a retrospective review of the outcomes of metastasectomy for recurrent or metastatic BTCs, comprising intrahepatic cholangiocellular carcinoma (IHCCC), proximal and distal common bile duct cancer (pCBDC and dCBDC), gallbladder cancer (GBC), and ampulla of Vater cancer (AoVC). PATIENTS AND METHODS: The clinicopathological features and outcomes of BTC patients who underwent surgical resection for the primary and metastatic disease at the Gachon University Gil Medical Centre from 2003 to 2013 were reviewed retrospectively...
January 2017: Indian Journal of Cancer
https://www.readbyqxmd.com/read/29133247/contrast-ultrasound-li-rads-lr-5-identifies-hepatocellular-carcinoma-in-cirrhosis-in-a-multicenter-restropective-study-of-1-006-nodules
#14
Eleonora Terzi, Massimo Iavarone, Maurizio Pompili, Letizia Veronese, Giuseppe Cabibbo, Mirella Fraquelli, Laura Riccardi, Ludovico De Bonis, Angelo Sangiovanni, Simona Leoni, Maria Assunta Zocco, Sandro Rossi, Nicola Alessi, Stephanie R Wilson, Fabio Piscaglia
BACKGROUND & AIMS: The use of contrast enhanced ultrasound (CEUS) for the diagnosis of hepatocellular carcinoma (HCC) in cirrhosis was questioned because of the risk of a false positive diagnosis in cases of cholangiocarcinoma. The American College of Radiology has recently released a scheme (CEUS Liver Imaging Reporting and Data System [LI-RADS®]) to classify lesions at risk of HCC investigated by CEUS. The aim of the present study was to validate this LI-RADS scheme for the diagnosis of HCC...
March 2018: Journal of Hepatology
https://www.readbyqxmd.com/read/29080443/hepatic-sarcoidosis-mimicking-cholangiocellular-carcinoma-a-case-report-and-literature-review
#15
Ryoichi Miyamoto, Naoki Sano, Sosuke Tadano, Satoshi Inagawa, Shinya Adachi, Masayoshi Yamamoto
INTRODUCTION: Sarcoidosis is a multisystem disease characterized by the presence of non-caseating granulomas in affected organs. Almost 70% of patients with a sarcoidosis reaction have hepatic involvement. However, evidence-based clinical management or treatment strategies for hepatic sarcoidosis are poorly defined. Here, we present a case of a resected hepatic sarcoidosis patient. Additionally, we review the relevant hepatic sarcoidosis literature and discuss the clinical management of hepatic sarcoidosis...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29042975/comparison-of-dwibs-t2-image-fusion-and-pet-ct-for-the-diagnosis-of-cancer-in-the-abdominal-cavity
#16
Minoru Tomizawa, Fuminobu Shinozaki, Yoshitaka Uchida, Katsuhiro Uchiyama, Satomi Tanaka, Takafumi Sunaoshi, Daisuke Kano, Eriko Sugiyama, Misaki Shite, Ryouta Haga, Yoshiya Fukamizu, Toshiyuki Fujita, Satoshi Kagayama, Rumiko Hasegawa, Yoshinori Shirai, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige
Fusion images of diffusion-weighted whole-body imaging with background body signal suppression and T2-weighted image (DWIBS/T2) demonstrate a strong signal for malignancies, with a high contrast against the surrounding tissues, and enable anatomical analysis. In the present study, DWIBS/T2 was compared with18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) for diagnosing cancer in the abdomen. Patient records, including imaging results of examination conducted between November 2012 and May 2014, were analyzed retrospectively...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28955001/aggressive-resection-of-metachronous-triple-biliary-cancer
#17
Masato Yoshikawa, Tetsuya Ikemoto, Yuji Morine, Satoru Imura, Yu Saito, Shinichiro Yamada, Hiroki Teraoku, Atsushi Takata, Toshiaki Yoshimoto, Mitsuo Shimada
Radical resection of recurrent cholangiocellular carcinoma (CCC) is rare. To date, only two patients have been reported to undergo major hepatectomy twice after pancreatoduodenectomy (PD) for metachronous CCC. This report describes a patient who underwent three metachronous radical resections of CCC with curative intent, consisting of PD followed by two hepatectomies, for cancer of the middle bile duct. A 60 year old male, who had undergone a distal gastrectomy for duodenal ulcer perforation in 23 years ago, underwent PD (Honjo method) for middle bile duct cancer (papillary adenocarcinoma) in 20 years ago at another hospital...
2017: Journal of Medical Investigation: JMI
https://www.readbyqxmd.com/read/28943569/intrahepatic-cholangiolocellular-and-cholangiocellular-carcinoma-differences-in-the-18-f-fdg-pet-ct-findings
#18
Yoshiko Takahashi, Shuichi Sato, Hitomi Ishitobi, Makoto Nagaoka, Yoshiya Kobayashi, Hiroyuki Fukuhara, Mika Yuki, Yoshinori Komazawa, Hiroyuki Kuroda, Toshihiro Shizuku
Cholangiolocellular carcinoma is a minor primary cancerous tumor of the liver and its coexistence with intrahepatic cholangiocarcinoma in the liver is rare. We herein report a case of concurrent cholangiolocellular carcinoma and intrahepatic cholangiocarcinoma in the liver, in addition to a rectal G1 neuroendocrine tumor, a so-called carcinoid. The intrahepatic tumors showed a different uptake in the18 F-fluoro-2-deoxyglucose (FDG) positron-emission tomography (PET)/computed tomography (CT) findings. In addition to conventional dynamic contrast-enhanced CT, we concluded that FDG PET/CT could therefore be a helpful modality to identify the properties of both cholangiolocellular carcinoma and intrahepatic cholangiocarcinoma...
November 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28916905/small-cholangiolocellular-carcinoma-that-was-difficult-to-distinguish-from-cholangiocellular-carcinoma-a-case-report
#19
Norihiro Ishii, Kenichiro Araki, Takahiro Yamanaka, Tadashi Handa, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Shinichi Aishima, Hiroyuki Kuwano, Ken Shirabe
BACKGROUND: Cholangiolocellular carcinoma (CoCC) is thought to be derived from hepatic progenitor cells. Because of its origin, CoCC has diverse clinicopathological and imaging findings. Here, we report a case of small CoCC that was difficult to diagnose preoperatively. CASE PRESENTATION: A 62-year-old woman was confirmed with a small liver nodule in the left lobe 2 years after a sustained virological response of hepatitis C virus. The size of the nodule was 11...
September 15, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28913125/bilateral-ovarian-metastasis-of-a-klatskin-tumor-a-rare-case
#20
Sefa Kurt, Çağnur Ulukuş, Seher Nazlı Kazaz, İbrahim Astarcıoğlu
Metastatic carcinomas of the ovary have an important place in all ovarian cancers and tumors. They can originate from many organs and systems and may metastasize to the ovary. The most common primary origin of metastasis is the gastrointestinal tract and then breast tissue. Cholangiocellular carcinomas involving the junction of the right and left bile ducts are called Klatskin tumors, and their metastases to the ovaries are very rare. A woman aged 54 years who had been treated previously for Klatskin tumor was admitted to our clinic due to bilateral ovarian masses and high serum calcium 19-9 levels...
December 2016: Turkish Journal of Obstetrics and Gynecology
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