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Cholangiocellular carcinoma

Keita Yamashiro, Astushi Hori, Takeo Yuki, Ryosuke Ohira, Shinichi Hori
Here, we report a case of cholangiocellular carcinoma that was successfully treated with chemotherapy using a selective intra-arterial infusion technique. A 65-year-old man presented to our hospital to obtain a second opinion regarding his disease. The patient was diagnosed with cholangiocellular carcinoma. The giant tumor was located in the porta hepatis. Some small nodules that were considered to be metastatic lesions were also observed in the surroundingarea. The tumor was judged by the primary physician to be too large for surgical treatment...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
L Zender, N P Malek
Cholangiocellular carcinoma (CCA) is the second most frequent primary liver carcinoma and is an aggressive tumor, which is mostly diagnosed in advanced stages. The overall survival is poor. Histpathological analysis of tumor biopsies or cytological analysis of biliary brushings can be used to confirm the diagnosis. A differentiation is made between distal, perihilar and intrahepatic CCA. The anatomical position determines the diagnostic and therapeutic strategy. Before diagnostic or therapeutic measures are undertaken it is essential to resolve biliary obstruction via endoscopic stenting or percutaneous biliary drainage...
December 2016: Der Internist
Alessandro Cucchetti, Alberta Cappelli, Giorgio Ercolani, Cristina Mosconi, Matteo Cescon, Rita Golfieri, Antonio Daniele Pinna
BACKGROUND: Many patients with primary liver cancers are not candidates for surgery, and systemic therapies are seldom effective. Selective internal radiation therapy (SIRT) has been shown to obtain partial and even complete response in unresectable primary tumors. As a "side effect", SIRT can induce contra-lateral liver hypertrophy. Tumor response to SIRT can be sufficient to allow disengagement from normal vital structures whose involvement is the cause of the initial unresectability...
October 2016: Liver Cancer
Wataru Fujii, Ken Hayashi, Shigetoshi Yamada, Hiroshi Kusanagi
INTRODUCTION: For carcinoma of the ampulla of Vater, lymph node metastasis around the abdominal aorta is an inoperable factor equivalent to distant metastasis, such as hepatic metastasis or peritoneal carcinomatosis, making the cancer unresectable. PRESENTATION OF CASE: A 53-year-old man was referred to our hospital and was diagnosed as having carcinoma of the ampulla of Vater with lymph node metastases around the abdominal aorta. Although only chemotherapy was initially scheduled, the chemotherapy was effective, and the metastases were dramatically reduced after 4 cycles of chemotherapy...
October 8, 2016: International Journal of Surgery Case Reports
Satoshi Nagayama, Suguru Hasegawa, Koya Hida, Kenji Kawada, Etsuro Hatano, Kojiro Nakamura, Satoru Seo, Kojiro Taura, Kentaro Yasuchika, Takashi Matsuo, Masazumi Zaima, Akiyoshi Kanazawa, Hiroaki Terajima, Masaharu Tada, Yukihito Adachi, Ryuta Nishitai, Dai Manaka, Tsunehiro Yoshimura, Koji Doi, Takahiro Horimatsu, Akira Mitsuyoshi, Kenichi Yoshimura, Miyuki Niimi, Shigemi Matsumoto, Yoshiharu Sakai, Shinji Uemoto
BACKGROUND: Although liver resection combined with preoperative chemotherapy is expected to improve outcomes of patients with resectable colorectal liver metastasis (CRLM), there is as yet insufficient clinical evidence supporting the efficacy of preoperative systemic chemotherapy. The aim of this phase II study was to assess the feasibility and efficacy of preoperative FOLFOX systemic chemotherapy for patients with initially resectable CRLM. METHODS: A prospective multi-institutional phase II study was conducted to evaluate the feasibility and efficacy of preoperative chemotherapy for resectable CRLM (ClinicalTrials...
October 17, 2016: International Journal of Clinical Oncology
Kazuto Kozaka, Osamu Matsui, Satoshi Kobayashi, Wataru Koda, Tetsuya Minami, Azusa Kitao, Dai Inoue, Norihide Yoneda, Kotaro Yoshida, Fumihito Toshima, Yasuni Nakanuma, Toshifumi Gabata
OBJECTIVES: To elucidate the dynamic CT features of pure type of cholangiolocellular carcinoma (pure CoCC) in comparison with those of cholangiocellular carcinoma (CCC) and to analyze their bases by angiography-assisted CT with histopathologic correlation. METHODS: Surgically confirmed 10 pure CoCCs, 10 CCCs and 7 mixed CoCC and CCCs from August 2001 to May 2012 were included in this study. Among them, dynamic CT features were compared. In 8 pure CoCCs, the correlative study between angiography-assisted CT and histopathological study was performed to clarify the basic mechanism of dynamic CT features...
October 17, 2016: Abdominal Radiology
Thomas B Brunner, Thomas Seufferlein
Cholangiocarcinoma can arise in all parts of the biliary tract and this has implications for therapy. Surgery is the mainstay of therapy however local relapse is a major problem. Therefore, adjuvant treatment with chemoradiotherapy was tested in trials. The SWOG-S0809 trial regimen of chemoradiotherapy which was tested in extrahepatic cholangiocarcinoma and in gallbladder cancer can currently be regarded as highest level of evidence for this indication. In contrast to adjuvant therapy where only conventionally fractionated radiotherapy plays a role, stereotactic body radiotherapy (SBRT) today has become a powerful alternative to chemoradiotherapy for definitive treatment due to the ability to administer higher doses of radiotherapy to improve local control...
August 2016: Best Practice & Research. Clinical Gastroenterology
Goushi Murakami, Atsushi Nanashima, Takashi Nonaka, Tetsuro Tominaga, Kouki Wakata, Yorihisa Sumida, Haruo Akashi, Shigetoshi Okazaki, Hiromi Kataoka, Takeshi Nagayasu
BACKGROUND/AIM: Photodynamic therapy (PDT) is an effective laser treatment for locally treating advanced bile duct carcinoma (BDC). The study's objective was to evaluate the increased cytocidal effect by apoptotic PDT using a novel photosensitizer, glucose-conjugated chlorin, by irradiation of light-emitting diode laser (G-PDT) in comparison with conventional PDT using talaporfin sodium (T-PDT). MATERIALS AND METHODS: The cytocidal effect of G-PDT was compared to that of T-PDT as a control...
September 2016: Anticancer Research
Sung Il Park, Il Jung Kim, Shin Jae Lee, Min Woo Shin, Won Sun Shin, Yong Eun Chung, Gyoung Min Kim, Man Deuk Kim, Jong Yun Won, Do Yun Lee, Jin Sub Choi, Kwang-Hyub Han
OBJECTIVE: To evaluate the feasibility of angled cool-tip electrode for radiofrequency ablation of small superficial subcapsular liver tumors abutting abdominal wall, in order to traverse normal liver parenchyma, and thereby, obtain favorable configuration of ablation margin. MATERIALS AND METHODS: In this study, we retrospectively analyzed 15 small superficial subcapsular liver tumors abutting abdominal wall in 15 patients, treated with radiofrequency ablation from March 2013 to June 2015 using a cool-tip electrode manually modified to create 25-35° angle at the junction between exposed and insulated segments...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
Matthias Unseld, Werner Scheithauer, Roman Weigl, Gabriela Kornek, Nadja Stranzl, Daniela Bianconi, Georg Brunauer, Guenther Steger, Christoph C Zielinski, Gerald W Prager
BACKGROUND: Advanced cholangiocellular carcinoma has a poor prognosis with limited therapeutic options. Nab-paclitaxel has recently been described to be beneficial in metastatic pancreatic cancer improving overall and progression free survival (PFS). The potential antitumor activity of nab-paclitaxel in cholangiocellular carcinoma is hitherto unknown. METHODS: We retrospectively analyzed an institutional cholangiocellular carcinoma registry to determine the potential biological activity of nab-paclitaxel in advanced intrahepatic cholangiocellular carcinoma...
August 2016: Journal of Gastrointestinal Oncology
John R Bergquist, Ryan T Groeschl, Tommy Ivanics, Christopher R Shubert, Elizabeth B Habermann, Michael L Kendrick, Michael B Farnell, David M Nagorney, Mark J Truty, Rory L Smoot
BACKGROUND: Intrahepatic lesions of mixed hepatocellular (HCC) and intrahepatic cholangiocellular carcinoma (ICC) histology are rare. The aim was to describe the natural history of these tumors relative to monomorphic ICC or HCC utilizing the National Cancer Data Base (NCDB). METHODS: Patients with ICC, HCC, and mixed histology (cHCC-CCA) were identified in the NCDB (2004-2012). Inter-group comparisons were made. Kaplan-Meier and multivariable Cox Proportional Hazards analyzed overall survival...
August 18, 2016: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
Steffen Zender, Irina Nickeleit, Torsten Wuestefeld, Inga Sörensen, Daniel Dauch, Przemyslaw Bozko, Mona El-Khatib, Robert Geffers, Hueseyin Bektas, Michael P Manns, Achim Gossler, Ludwig Wilkens, Ruben Plentz, Lars Zender, Nisar P Malek
No abstract text is available yet for this article.
August 8, 2016: Cancer Cell
B Schellhaas, D Wildner, L Pfeifer, R S Goertz, A Hagel, M F Neurath, D Strobel
Purpose: To develop a contrast-enhanced ultrasound algorithm (LI-RADS-CEUS = liver imaging reporting and data system with contrast-enhanced ultrasound) for the diagnosis of hepatocellular carcinoma (HCC) in patients at risk. Materials and Methods: A CEUS algorithm (LI-RADS-CEUS) was designed analogously to CT- and MRI-based LI-RADS. LI-RADS-CEUS was evaluated retrospectively in 50 patients at risk with confirmed HCC or non-HCC lesions (test group) with subsequent validation in a prospective cohort of 50 patients (validation group)...
August 3, 2016: Ultraschall in der Medizin
Mehdi Madanchi, Jonas Zeitz, Christiane Barthel, Panagiotis Samaras, Sylvie Scharl, Michael C Sulz, Luc Biedermann, Pascal Frei, Stephan R Vavricka, Gerhard Rogler, Michael Scharl
BACKGROUND: Gastrointestinal and extraintestinal malignancies are long-term complications in patients with inflammatory bowel disease (IBD), likely as a result of chronic inflammation and the use of immunosuppressive medications used to control inflammation. Here, we assessed the frequency of malignancies in a large tertiary IBD centre at the University Hospital Zurich. METHODS: We performed a retrospective analysis of data from 1,026 patients from our IBD clinic treated between 2007 and 2014...
2016: Digestion
Alexander Semaan, Vittorio Branchi, Anna-Lena Marowsky, Martin VON Websky, Patrick Kupczyk, Simon Jonas Enkirch, Guido Kukuk, Edwin Bölke, Burkhard Stoffels, Jörg C Kalff, Nico Schäfer, Philipp Lingohr, Hanno Matthaei
BACKGROUND: Detection of asymptomatic focal liver lesions (FLL) is increasing because of a widespread use of modern radiologic imaging. Most of these lesions are benign, though malignancy often has to be ruled out, which is posing a diagnostic challenge. AIM: To critically evaluate our treatment strategy in the context of recently published American College of Gastroenterology (ACG) guidelines. PATIENTS AND METHODS: The medical records of patients who underwent surgery for asymptomatic, incidentally detected FLL from 2005-2012 were reviewed...
June 2016: Anticancer Research
Juliane Friemel, Markus Rechsteiner, Marion Bawohl, Lukas Frick, Beat Müllhaupt, Mickaël Lesurtel, Achim Weber
BACKGROUND: In the spectrum of molecular alterations found in hepatocellular carcinoma (HCC), somatic mutations in the WNT/β-catenin pathway and the p53/cell cycle control pathway are among the most frequent ones. It has been suggested that both mutations occur in a mutually exclusive manner and they are used as molecular classifiers in HCC classification proposals. CASE PRESENTATION: Here, we report the case of a treatment-naïve mixed hepatocellular/cholangiocellular carcinoma (HCC/CCC) with morphological and genetic intratumor heterogeneity...
2016: BMC Clinical Pathology
H Rudolph, F Neser, M Berger, J Boese-Landgraf
Background: Roux-Y hepaticojejunostomy is currently the standard surgical procedure for the reconstruction of the bile duct after iatrogenic transection in laparoscopic cholecystectomy. However, about 30 % of all hepaticojejunostomies develop a stenosis after some time and in 7 % a cholangiocellular carcinoma occurs. Therefore, alternative procedures have been investigated. Patients: Between September 2009 and October 2013 an iatrogenic bile duct lesion was treated in 6 consecutive patients by using the pedicled umbilical vein...
May 31, 2016: Zentralblatt Für Chirurgie
Sebastian Cammann, Kai Timrott, Ralf-Peter Vonberg, Florian W R Vondran, Harald Schrem, Sebastian Suerbaum, Jürgen Klempnauer, Hüseyin Bektas, Moritz Kleine
BACKGROUND: Hepatobiliary surgery with biliodigestive anastomosis (BDA) results in a loss of the sphincter of Oddi with consecutive ascension of bacteria into the bile system which may cause cholangitis in the postoperative course. METHODS: Patients who received reconstruction with a BDA after hepatobiliary surgery were analyzed retrospectively for their postoperative course of disease depending on intraoperatively obtained bile cultures and antibiotic prophylaxis...
August 2016: Langenbeck's Archives of Surgery
Nils Heits, Tillmann Heinze, Alexander Bernsmeier, Jannik Kerber, Charlotte Hauser, Thomas Becker, Holger Kalthoff, Jan-Hendrik Egberts, Felix Braun
BACKGROUND: The incidence of Cholangiocellular Carcinoma (CCA) is increasing in the western world. The tumour has a high proportion of desmoplastic stroma and is correlated with a worse prognosis when cancer associated myofibroblasts (CAFs) are present. Recent studies showed promising results after liver transplantation (LTx) in non-resectable early stage CCA. Mycophenolic acid (MPA) and the mTor inhibitor Everolimus are used to prevent organ rejection but recently were shown to exhibit an antiproliferative effect on CCA-cells...
2016: BMC Cancer
Hao Li, Xi-tao Wang, Ai-qun Zhang, Xiang-fei Meng, Qiang Yu, Wen-ping Lü, Wei-dong Duan, Jia-hong Dong
OBJECTIVE: To compare the predictive values of eight staging systems for primary liver cancer in the prognosis of combined hepatocellular-cholangiocellular carcinoma (cHCC-CC) patients after surgery. METHODS: The clinical data of 54 cHCC-CC patients who underwent hepatectomy or liver transplantation from May 2005 to Augest 2013 in Chinese PLA General Hospital were collected. We evaluated the prognostic value of the Okuda staging system, Cancer of the Liver Italian Program (CLIP) score, French staging system, Barcelona Clinic Liver Cancer (BCLC) staging system, 7th edition of tumour-node-metastasis (TNM) staging system for hepatocellular carcinoma and intrahepatic cholangiocarcinoma (ICC), Japan Integrated Staging (JIS) score, and Chinese University Prognostic Index...
April 2016: Zhongguo Yi Xue Ke Xue Yuan Xue Bao. Acta Academiae Medicinae Sinicae
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