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Cholangiocellular carcinoma

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https://www.readbyqxmd.com/read/28288474/cholangiocellular-carcinoma
#1
Arndt Vogel, Anna Saborowski
BACKGROUND: Cholangiocarcinomas (CCAs) are aggressive malignancies that display features of biliary differentiation. According to their anatomical location, CCAs are commonly classified as intrahepatic and extrahepatic tumors, the latter entity being further subdivided into perihilar CCAs, also termed as Klatskin tumors, and distal tumors. While a majority of CCAs occur sporadically, established risk factors such as liver fluke infestation or primary sclerosing cholangitis exist. SUMMARY: Due to lack of efficient early screening markers, CCAs are frequently diagnosed at an advanced stage when curative surgical resection is not an option...
March 14, 2017: Digestion
https://www.readbyqxmd.com/read/28211805/diagnostic-accuracy-and-interobserver-variability-of-dynamic-vascular-pattern-dvp-in-primary-liver-malignancies-a-simple-semiquantitative-tool-for-the-analysis-of-contrast-enhancement-patterns
#2
B Schellhaas, M J Waldner, R S GÖrtz, F Vitali, Ch Kielisch, L Pfeifer, D Strobel, R Janka, M F Neurath, D Wildner
BACKGROUND: Contrast-enhanced ultrasound (CEUS) is a valuable tool in the diagnostic approach of focal liver lesions, but occasionally subjective and observer-dependent. Semiquantitative evaluation of dynamic CEUS (DCEUS) with standardised software programmes such as Dynamic Vascular Pattern (DVP) could help to improve diagnostic accuracy and objectivity in liver tumour assessment. OBJECTIVES: The present study aimed at evaluation of diagnostic accuracy of DVP in a clinical setting...
February 17, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28192388/degradable-starch-microspheres-transcatheter-arterial-chemoembolization-dsm-tace-in-intrahepatic-cholangiocellular-carcinoma-icc-results-from-a-national-multi-center-study-on-safety-and-efficacy
#3
Andreas Schicho, Philippe L Pereira, Manfred Pützler, Katharina Michalik, Thomas Albrecht, Claus Nolte-Ernsting, Christian Stroszczynski, Philipp Wiggermann
BACKGROUND The aim of this study was to evaluate the safety and efficacy of DSM (degradable starch microspheres) as an embolic agent in transarterial chemoembolization in the treatment of intrahepatic cholangiocellular carcinoma (ICC). MATERIAL AND METHODS This was a national, multi-center observational cohort study on the safety and efficacy of DSM-TACE using mitomycin, gemcitabine, cisplatin, doxorubicin, and carboplatin in palliative treatment of ICC. Recruitment period for the study was from January 2010 to June 2014...
February 13, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28133246/-a-family-with-peutz-jeghers-syndrome-having-various-malignant-diseases
#4
Toshiro Ogura, Toru Ishiguro, Yu Muta, Minoru Fukuchi, Tomonori Nagai, Youichi Kumagai, Keiichiro Ishibashi, Erito Mochiki, Hideyuki Ishida
We report a 27-year-old female who was diagnosed with adenocarcinoma of the uterine cervix associated with Peutz- Jeghers syndrome(PJS). She had undergone 5 surgeries for intestinal intussusception and had been diagnosed with PJS. She was referred to our hospital, complaining of watery vaginal discharge, and was diagnosed with adenocarcinoma of the uterine cervix. Following neoadjuvant chemotherapy, radical hysterectomy and small intestinal polypectomy by intraoperative endoscopy were performed. Among the third-degree relatives of her family, 10 had been diagnosed with PJS; of these 10, uterine cervical adenocarcinoma occurred in 3 relatives, pancreatic cancer in 2, cholangiocellular carcinoma in 1, and colon cancer in 1...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133200/-a-case-of-synchronous-double-cancers-of-the-liver-and-pancreas-treated-using-pancreaticoduodenectomy-and-liver-resection
#5
Yasuji Hashimoto, Yo Sasaki, Shigekazu Yokoyama, Yoko Yamamoto, Shintaro Michishita, Hajime Hirose, Kenichi Nagai, Tomohiro Maniwa, Yoshihito Ide, Jin Matsuyama, Masashi Takeda, Takashi Morimoto, Yukio Fukushima, Ken Kodama
A 50-year-old woman had a 12mm liver tumor at segment 4 and was diagnosed with hemangioma. Two years later, the liver tumor had grown to 27mm in diameter, and a new pancreatic tumor was detected using CT examination. The pancreatic tumor was suspected of being pancreatic carcinoma, based on the results of endoscopic-ultrasound-guided fine-needlebiopsy( EUS-FNA)of the pancreas. The liver tumor was diagnosed as adenocarcinoma using liver biopsy. Because of its slow growth and the solitary liver tumor, synchronous pancreatic cancer and intrahepatic cancer were suspected...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133130/-a-resected-case-of-intraductal-pupillary-mucinous-neoplasm-of-the-pancreas-characterized-by-recurrence-in-the-remnant-pancreas-and-multiple-malignant-neoplasms-in-other-organs
#6
Ryo Yoshioka, Yoshito Tomimaru, Kozo Noguchi, Hirotsugu Nagase, Atsushi Hamabe, Masashi Hirota, Kazuteru Oshima, Tsukasa Tanida, Tomono Kawase, Shunji Morita, Hiroshi Imamura, Takashi Iwazawa, Kenzo Akagi, Shiro Adachi, Keizo Dono
A 74-year-old man underwent pancreaticoduodenectomy for intraductal pupillary mucinous neoplasm(IPMN)of the pancreatic head. Histopathological examination of the specimen revealed non-invasive intraductal papillary mucinous carcinoma( IPMC). Two years after surgery, recurrent IPMN developed in the remnant pancreas, and a liver tumor was identified in S8 of the liver. The patient underwent total pancreatectomy of the remnant pancreas and partial resection of S8. These tumors were histopathologically diagnosed as invasive IPMC and hepatocellular carcinoma, respectively...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28094162/intrahepatic-cholangiocarcinoma
#7
Masayuki Nakano, Shun-Ichi Ariizumi, Masakazu Yamamoto
Cholangiocarcinoma, also referred to as cholangiocellular carcinoma (particularly in Japan), develops along the biliary tract. The tumor may be intra- or extrahepatic and have different features with specific treatments based on the site of origin. Guidelines for diagnosis and management of cholangiorcarcinoma, such as those proposed by EASL (European Association for the Study of the Liver)(1) and the Mayo Clinic(2) classify the tumor into intrahepatic, perihilar, and distal cholangiocarcinoma. There are three main macroscopic patterns of growth of cholangiocarcinoma: mass-forming, periductal-infiltrating and intraductal...
January 5, 2017: Seminars in Diagnostic Pathology
https://www.readbyqxmd.com/read/27981308/primary-biliary-cirrhosis-and-primary-sclerosing-cholangitis-an-update-on-mr-imaging-findings-with-recent-developments
#8
REVIEW
Jelena Djokić Kovač, Marc-André Weber
Primary sclerosing cholangitis (PSC) and primary biliary cirrhosis (PBC) are the most common immune-mediated chronic cholestatic liver diseases leading to cirrhosis and liver failure. Although magnetic resonance imaging (MRI) is not a necessary procedure for the diagnosis of PBC, MRI is recommended for monitoring disease progression and early detection of complications. Even though liver cirrhosis subtypes have similar MR imaging features, there are some findings which could indicate PBC, such as the periportal halo sign...
December 2016: Journal of Gastrointestinal and Liver Diseases: JGLD
https://www.readbyqxmd.com/read/27960221/-extended-left-hemihepatectomy-with-reconstruction-of-the-right-liver-vein-in-a-patient-with-an-intrahepatic-cholangiocellular-carcinoma
#9
F Bartsch, T Huber, H Lang
Extended left hemihepatectomy (left trisectionectomy) with resection of liver segments 1, 2, 3, 4 a/b, 5 and 8 is a challenging procedure. In well-selected patients, the indication for this procedure may offer the chance of curative resection for primary or secondary liver tumours in complicated locations. Morbidity and mortality are increased compared to non-extended liver resections. This procedure requires precise imaging and accurate surgical planning in due consideration of the remaining liver volume and additional factors such as preliminary damage of the liver parenchyma caused by chemotherapy or fibrosis/cirrhosis...
December 2016: Zentralblatt Für Chirurgie
https://www.readbyqxmd.com/read/27938792/surveillance-in-cholangiocellular-carcinoma
#10
REVIEW
Thomas C Wirth, Arndt Vogel
Cholangiocellular carcinoma is the most frequent malignant neoplasm originating from the epithelium of intra- or extrahepatic bile ducts. In the past decades, the incidence of cholangiocarcinoma has been shown to increase while overall mortality has remained high with an approximate 5-year overall survival below 20%. Surgery remains the only curative option while systemic treatment is limited to palliative chemotherapy. Therefore, surveillance strategies for patients at risk of developing cholangiocarcinoma are urgently needed, particularly in patients with primary sclerosing cholangitis and patients infected with liver flukes...
December 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27932303/one-sample-one-shot-evaluation-of-sample-preparation-protocols-for-the-mass-spectrometric-proteome-analysis-of-human-bile-fluid-without-extensive-fractionation
#11
Dominik A Megger, Juliet Padden, Kristin Rosowski, Julian Uszkoreit, Thilo Bracht, Martin Eisenacher, Christian Gerges, Horst Neuhaus, Brigitte Schumacher, Jörg F Schlaak, Barbara Sitek
The proteome analysis of bile fluid represents a promising strategy to identify biomarker candidates for various diseases of the hepatobiliary system. However, to obtain substantive results in biomarker discovery studies large patient cohorts necessarily need to be analyzed. Consequently, this would lead to an unmanageable number of samples to be analyzed if sample preparation protocols with extensive fractionation methods are applied. Hence, the performance of simple workflows allowing for "one sample, one shot" experiments have been evaluated in this study...
February 10, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27899782/-trans-arterial-chemoembolization-therapy-for-giant-cholangiocellular-carcinoma-a-single-case-report
#12
Keita Yamashiro, Astushi Hori, Takeo Yuki, Ryosuke Ohira, Shinichi Hori
Here, we report a case of cholangiocellular carcinoma that was successfully treated with chemotherapy using a selective intra-arterial infusion technique. A 65-year-old man presented to our hospital to obtain a second opinion regarding his disease. The patient was diagnosed with cholangiocellular carcinoma. The giant tumor was located in the porta hepatis. Some small nodules that were considered to be metastatic lesions were also observed in the surroundingarea. The tumor was judged by the primary physician to be too large for surgical treatment...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/27822622/-diagnostics-and-treatment-of-cholangiocellular-carcinoma
#13
L Zender, N P Malek
Cholangiocellular carcinoma (CCA) is the second most frequent primary liver carcinoma and is an aggressive tumor, which is mostly diagnosed in advanced stages. The overall survival is poor. Histpathological analysis of tumor biopsies or cytological analysis of biliary brushings can be used to confirm the diagnosis. A differentiation is made between distal, perihilar and intrahepatic CCA. The anatomical position determines the diagnostic and therapeutic strategy. Before diagnostic or therapeutic measures are undertaken it is essential to resolve biliary obstruction via endoscopic stenting or percutaneous biliary drainage...
December 2016: Der Internist
https://www.readbyqxmd.com/read/27781202/selective-internal-radiation-therapy-sirt-as-conversion-therapy-for-unresectable-primary-liver-malignancies
#14
REVIEW
Alessandro Cucchetti, Alberta Cappelli, Giorgio Ercolani, Cristina Mosconi, Matteo Cescon, Rita Golfieri, Antonio Daniele Pinna
BACKGROUND: Many patients with primary liver cancers are not candidates for surgery, and systemic therapies are seldom effective. Selective internal radiation therapy (SIRT) has been shown to obtain partial and even complete response in unresectable primary tumors. As a "side effect", SIRT can induce contra-lateral liver hypertrophy. Tumor response to SIRT can be sufficient to allow disengagement from normal vital structures whose involvement is the cause of the initial unresectability...
October 2016: Liver Cancer
https://www.readbyqxmd.com/read/27756031/curative-resection-of-carcinoma-of-the-ampulla-of-vater-with-lymph-node-metastases-around-the-abdominal-aorta-after-chemotherapy-a-case-report
#15
Wataru Fujii, Ken Hayashi, Shigetoshi Yamada, Hiroshi Kusanagi
INTRODUCTION: For carcinoma of the ampulla of Vater, lymph node metastasis around the abdominal aorta is an inoperable factor equivalent to distant metastasis, such as hepatic metastasis or peritoneal carcinomatosis, making the cancer unresectable. PRESENTATION OF CASE: A 53-year-old man was referred to our hospital and was diagnosed as having carcinoma of the ampulla of Vater with lymph node metastases around the abdominal aorta. Although only chemotherapy was initially scheduled, the chemotherapy was effective, and the metastases were dramatically reduced after 4 cycles of chemotherapy...
October 8, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27752787/multi-institutional-phase-ii-study-on-the-feasibility-of-liver-resection-following-preoperative-mfolfox6-therapy-for-resectable-liver-metastases-from-colorectal-cancers
#16
Satoshi Nagayama, Suguru Hasegawa, Koya Hida, Kenji Kawada, Etsuro Hatano, Kojiro Nakamura, Satoru Seo, Kojiro Taura, Kentaro Yasuchika, Takashi Matsuo, Masazumi Zaima, Akiyoshi Kanazawa, Hiroaki Terajima, Masaharu Tada, Yukihito Adachi, Ryuta Nishitai, Dai Manaka, Tsunehiro Yoshimura, Koji Doi, Takahiro Horimatsu, Akira Mitsuyoshi, Kenichi Yoshimura, Miyuki Niimi, Shigemi Matsumoto, Yoshiharu Sakai, Shinji Uemoto
BACKGROUND: Although liver resection combined with preoperative chemotherapy is expected to improve outcomes of patients with resectable colorectal liver metastasis (CRLM), there is as yet insufficient clinical evidence supporting the efficacy of preoperative systemic chemotherapy. The aim of this phase II study was to assess the feasibility and efficacy of preoperative FOLFOX systemic chemotherapy for patients with initially resectable CRLM. METHODS: A prospective multi-institutional phase II study was conducted to evaluate the feasibility and efficacy of preoperative chemotherapy for resectable CRLM (ClinicalTrials...
October 17, 2016: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27747442/dynamic-ct-findings-of-cholangiolocellular-carcinoma-correlation-with-angiography-assisted-ct-and-histopathology
#17
Kazuto Kozaka, Osamu Matsui, Satoshi Kobayashi, Wataru Koda, Tetsuya Minami, Azusa Kitao, Dai Inoue, Norihide Yoneda, Kotaro Yoshida, Fumihito Toshima, Yasuni Nakanuma, Toshifumi Gabata
OBJECTIVES: To elucidate the dynamic CT features of pure type of cholangiolocellular carcinoma (pure CoCC) in comparison with those of cholangiocellular carcinoma (CCC) and to analyze their bases by angiography-assisted CT with histopathologic correlation. METHODS: Surgically confirmed 10 pure CoCCs, 10 CCCs and 7 mixed CoCC and CCCs from August 2001 to May 2012 were included in this study. Among them, dynamic CT features were compared. In 8 pure CoCCs, the correlative study between angiography-assisted CT and histopathological study was performed to clarify the basic mechanism of dynamic CT features...
October 17, 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/27644907/radiation-therapy-in-cholangiocellular-carcinomas
#18
REVIEW
Thomas B Brunner, Thomas Seufferlein
Cholangiocarcinoma can arise in all parts of the biliary tract and this has implications for therapy. Surgery is the mainstay of therapy however local relapse is a major problem. Therefore, adjuvant treatment with chemoradiotherapy was tested in trials. The SWOG-S0809 trial regimen of chemoradiotherapy which was tested in extrahepatic cholangiocarcinoma and in gallbladder cancer can currently be regarded as highest level of evidence for this indication. In contrast to adjuvant therapy where only conventionally fractionated radiotherapy plays a role, stereotactic body radiotherapy (SBRT) today has become a powerful alternative to chemoradiotherapy for definitive treatment due to the ability to administer higher doses of radiotherapy to improve local control...
August 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27630287/photodynamic-therapy-using-novel-glucose-conjugated-chlorin-increases-apoptosis-of-cholangiocellular-carcinoma-in-comparison-with-talaporfin-sodium
#19
COMPARATIVE STUDY
Goushi Murakami, Atsushi Nanashima, Takashi Nonaka, Tetsuro Tominaga, Kouki Wakata, Yorihisa Sumida, Haruo Akashi, Shigetoshi Okazaki, Hiromi Kataoka, Takeshi Nagayasu
BACKGROUND/AIM: Photodynamic therapy (PDT) is an effective laser treatment for locally treating advanced bile duct carcinoma (BDC). The study's objective was to evaluate the increased cytocidal effect by apoptotic PDT using a novel photosensitizer, glucose-conjugated chlorin, by irradiation of light-emitting diode laser (G-PDT) in comparison with conventional PDT using talaporfin sodium (T-PDT). MATERIALS AND METHODS: The cytocidal effect of G-PDT was compared to that of T-PDT as a control...
2016: Anticancer Research
https://www.readbyqxmd.com/read/27587963/angled-cool-tip-electrode-for-radiofrequency-ablation-of-small-superficial-subcapsular-tumors-in-the-liver-a-feasibility-study
#20
Sung Il Park, Il Jung Kim, Shin Jae Lee, Min Woo Shin, Won Sun Shin, Yong Eun Chung, Gyoung Min Kim, Man Deuk Kim, Jong Yun Won, Do Yun Lee, Jin Sub Choi, Kwang-Hyub Han
OBJECTIVE: To evaluate the feasibility of angled cool-tip electrode for radiofrequency ablation of small superficial subcapsular liver tumors abutting abdominal wall, in order to traverse normal liver parenchyma, and thereby, obtain favorable configuration of ablation margin. MATERIALS AND METHODS: In this study, we retrospectively analyzed 15 small superficial subcapsular liver tumors abutting abdominal wall in 15 patients, treated with radiofrequency ablation from March 2013 to June 2015 using a cool-tip electrode manually modified to create 25-35° angle at the junction between exposed and insulated segments...
September 2016: Korean Journal of Radiology: Official Journal of the Korean Radiological Society
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